[Hub]/) : Traits : Impedance of whole body : ← →

chr11:198,510-1,702,321

Best TWAS P=1.7e-12 · Best GWAS P=2.94e-13 conditioned to 0.129

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
24	GTEx	Brain Frontal Cortex BA9	AP006621.5	0.18	0.03	lasso	6	0.04	2.6e-02	6.6	-7.1	1.7e-12	-0.92	0.04	0.69	TRUE
12	GTEx	Artery Aorta	PSMD13	0.22	0.24	enet	13	0.30	1.2e-16	3.9	5.1	2.6e-07	0.04	0.08	0.57	TRUE
59	GTEx	Pancreas	EFCAB4A	0.23	0.19	enet	8	0.16	4.1e-07	7.2	-7.0	3.3e-12	-0.97	0.00	1.00	FALSE
26	GTEx	Brain Hypothalamus	PNPLA2	0.23	-0.01	lasso	9	0.00	4.0e-01	6.6	6.9	6.7e-12	0.93	0.04	0.33	FALSE
23	GTEx	Brain Frontal Cortex BA9	PIDD	0.32	0.15	lasso	2	0.11	6.9e-04	6.6	-6.7	1.6e-11	-0.95	0.02	0.84	FALSE
82	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHID1	0.06	0.05	blup	67	0.03	2.0e-02	-5.6	6.7	2.8e-11	0.66	0.04	0.24	FALSE
85	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CEND1	0.04	0.03	lasso	3	0.02	9.6e-04	6.6	-6.5	5.8e-11	-0.91	0.01	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2L	0.09	0.09	enet	16	0.10	4.6e-12	5.8	6.5	8.0e-11	0.63	0.97	0.03	FALSE
68	GTEx	Testis	POLR2L	0.16	0.03	enet	10	0.03	1.9e-02	5.4	6.5	1.1e-10	0.74	0.06	0.89	FALSE
86	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PNPLA2	0.07	0.00	blup	51	0.03	1.4e-04	5.8	-6.4	1.4e-10	-0.67	0.01	0.65	FALSE
93	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CHID1	0.07	0.05	blup	68	0.01	8.0e-02	5.4	6.4	1.4e-10	0.74	0.02	0.72	FALSE
96	The Cancer Genome Atlas	Rectum Adenocarcinoma	CHID1	0.25	0.16	blup	68	0.13	6.4e-04	5.8	6.4	1.4e-10	0.51	0.08	0.12	FALSE
49	GTEx	Heart Left Ventricle	AP006621.6	0.23	0.11	lasso	5	0.11	1.4e-06	-6.2	-6.3	3.2e-10	-0.80	0.09	0.91	FALSE
4	GTEx	Adipose Subcutaneous	PIDD	0.14	0.13	lasso	3	0.12	8.9e-10	-6.2	-6.2	4.2e-10	-0.82	0.47	0.53	FALSE
62	GTEx	Skin Sun Exposed Lower leg	PIDD	0.20	0.17	lasso	4	0.17	9.7e-14	-6.2	-6.2	5.6e-10	-0.80	0.63	0.37	FALSE
35	GTEx	Cells Transformed fibroblasts	PIDD	0.14	0.05	enet	13	0.04	2.8e-04	-5.4	-6.2	6.1e-10	-0.80	0.01	0.97	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	TSPAN4	0.09	0.04	enet	9	0.03	1.9e-04	-3.3	-6.2	6.7e-10	-0.60	0.18	0.63	FALSE
42	GTEx	Esophagus Gastroesophageal Junction	AP006621.5	0.37	0.36	lasso	2	0.35	2.1e-13	-6.2	-6.2	7.2e-10	-0.79	0.83	0.17	FALSE
77	METSIM	Adipose	POLR2L	0.03	0.02	bslmm	413	0.01	5.0e-03	3.9	6.2	7.3e-10	0.60	0.22	0.20	FALSE
79	YFS	Blood	POLR2L	0.26	0.19	bslmm	383	0.30	2.4e-98	5.8	-6.1	9.0e-10	-0.49	0.98	0.02	FALSE
15	GTEx	Artery Coronary	AP006621.6	0.26	0.11	enet	20	0.12	5.3e-05	-3.6	-6.1	9.8e-10	-0.81	0.04	0.94	FALSE
98	The Cancer Genome Atlas	Thyroid Carcinoma	CEND1	0.05	0.04	enet	8	0.03	1.2e-03	-6.1	-6.1	1.0e-09	-0.80	0.10	0.80	FALSE
51	GTEx	Liver	AP006621.5	0.38	0.18	enet	8	0.17	1.6e-05	-6.2	-6.1	1.1e-09	-0.81	0.05	0.94	FALSE
70	GTEx	Thyroid	PIDD	0.18	0.15	lasso	5	0.14	1.6e-10	-6.2	-6.1	1.2e-09	-0.81	0.11	0.89	FALSE
6	GTEx	Adipose Subcutaneous	MIR210HG	0.11	0.01	lasso	6	0.01	7.2e-02	5.8	6.1	1.3e-09	0.52	0.12	0.33	FALSE
5	GTEx	Adipose Subcutaneous	POLR2L	0.19	0.12	enet	18	0.11	3.4e-09	5.9	6.0	1.6e-09	0.59	0.97	0.03	FALSE
56	GTEx	Nerve Tibial	POLR2L	0.15	0.03	enet	17	0.04	1.1e-03	3.9	6.0	1.8e-09	0.54	0.66	0.10	FALSE
11	GTEx	Artery Aorta	PIDD	0.21	0.22	enet	8	0.21	5.0e-12	-6.2	-6.0	2.1e-09	-0.80	0.80	0.20	FALSE
69	GTEx	Testis	AP006621.5	0.26	0.16	lasso	5	0.19	8.3e-09	-5.4	-6.0	2.1e-09	-0.79	0.05	0.95	FALSE
54	GTEx	Muscle Skeletal	AP006621.6	0.15	0.12	enet	10	0.14	1.6e-13	-3.7	-5.9	2.9e-09	-0.80	0.83	0.17	FALSE
75	METSIM	Adipose	AP006621.5	0.24	0.19	enet	34	0.20	1.5e-28	-5.4	-5.9	2.9e-09	-0.80	0.91	0.09	FALSE
60	GTEx	Pancreas	AP006621.8	0.28	0.10	lasso	6	0.14	2.5e-06	6.6	-5.9	3.3e-09	-0.84	0.01	0.99	FALSE
76	METSIM	Adipose	PIDD	0.13	0.15	lasso	3	0.15	6.0e-22	-5.8	-5.9	3.5e-09	-0.79	0.84	0.16	FALSE
36	GTEx	Cells Transformed fibroblasts	POLR2L	0.12	0.11	lasso	5	0.12	5.2e-09	5.9	5.9	3.9e-09	0.55	0.97	0.03	FALSE
37	GTEx	Cells Transformed fibroblasts	AP006621.5	0.38	0.26	lasso	6	0.30	5.0e-23	-5.4	-5.9	4.6e-09	-0.76	0.99	0.01	FALSE
87	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEND1	0.06	0.02	enet	9	0.04	7.7e-06	5.5	-5.9	4.6e-09	-0.63	0.14	0.70	FALSE
74	GTEx	Whole Blood	AP006621.5	0.15	0.16	lasso	5	0.14	1.1e-12	-5.4	-5.9	4.8e-09	-0.80	0.47	0.53	FALSE
63	GTEx	Skin Sun Exposed Lower leg	AP006621.6	0.25	0.20	lasso	7	0.20	4.3e-16	-5.4	-5.8	4.9e-09	-0.83	0.11	0.89	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	CEND1	0.03	0.04	lasso	1	0.03	2.6e-07	-5.8	-5.8	7.1e-09	-0.79	0.17	0.83	FALSE
83	The Cancer Genome Atlas	Glioblastoma Multiforme	CD151	0.13	0.02	blup	50	0.08	1.8e-03	3.8	-5.7	9.4e-09	-0.74	0.07	0.32	FALSE
71	GTEx	Thyroid	AP006621.6	0.22	0.14	lasso	3	0.14	4.7e-11	-5.4	-5.7	1.1e-08	-0.76	0.65	0.35	FALSE
80	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CHID1	0.03	0.01	blup	67	0.01	2.3e-02	5.8	5.7	1.1e-08	0.57	0.08	0.09	FALSE
47	GTEx	Esophagus Muscularis	AP006621.5	0.39	0.33	lasso	8	0.35	2.1e-22	-5.4	-5.7	1.3e-08	-0.79	0.83	0.17	FALSE
92	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEND1	0.05	0.00	blup	52	0.02	1.1e-02	3.9	-5.7	1.5e-08	-0.79	0.04	0.40	FALSE
84	The Cancer Genome Atlas	Glioblastoma Multiforme	LRDD	0.09	0.08	blup	54	0.10	7.8e-04	-6.1	-5.7	1.6e-08	-0.80	0.04	0.33	FALSE
10	GTEx	Adipose Visceral Omentum	AP006621.5	0.24	0.15	lasso	2	0.15	4.6e-08	-5.4	-5.6	1.7e-08	-0.77	0.69	0.30	FALSE
20	GTEx	Brain Cerebellar Hemisphere	PIDD	0.48	0.24	enet	28	0.30	2.4e-08	-6.2	-5.6	1.8e-08	-0.74	0.08	0.92	FALSE
32	GTEx	Breast Mammary Tissue (Female)	RPLP2	0.15	0.00	lasso	2	-0.01	8.2e-01	5.6	-5.6	1.9e-08	-0.74	0.04	0.10	FALSE
97	The Cancer Genome Atlas	Stomach Adenocarcinoma	CD151	0.03	0.00	blup	50	0.01	3.6e-02	4.1	-5.6	1.9e-08	-0.79	0.02	0.48	FALSE
33	GTEx	Breast Mammary Tissue (Female)	AP006621.5	0.22	0.19	lasso	2	0.20	1.7e-06	-5.4	-5.6	2.2e-08	-0.76	0.21	0.70	FALSE
91	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRDD	0.11	0.03	enet	14	0.04	4.0e-05	-6.1	-5.6	2.2e-08	-0.72	0.50	0.37	FALSE
31	GTEx	Breast Mammary Tissue	AP006621.5	0.28	0.28	lasso	4	0.32	3.5e-17	-5.4	-5.6	2.4e-08	-0.76	0.90	0.10	FALSE
38	GTEx	Colon Transverse	AP006621.6	0.33	0.23	lasso	3	0.19	2.6e-09	-5.4	-5.6	2.5e-08	-0.76	0.92	0.08	FALSE
66	GTEx	Stomach	AP006621.6	0.23	0.08	lasso	4	0.06	1.1e-03	-5.4	-5.6	2.5e-08	-0.74	0.18	0.69	FALSE
72	GTEx	Thyroid	AP006621.5	0.33	0.31	lasso	6	0.33	9.4e-26	-5.4	-5.6	2.5e-08	-0.78	0.97	0.03	FALSE
13	GTEx	Artery Aorta	AP006621.6	0.35	0.26	enet	13	0.26	9.6e-15	-5.4	-5.5	2.9e-08	-0.76	0.92	0.08	FALSE
46	GTEx	Esophagus Muscularis	AP006621.6	0.34	0.24	lasso	5	0.25	3.5e-15	-5.4	-5.5	3.1e-08	-0.78	0.87	0.13	FALSE
67	GTEx	Testis	AP006621.1	0.45	0.35	lasso	7	0.41	2.2e-19	-5.4	-5.5	3.1e-08	-0.77	0.79	0.21	FALSE
8	GTEx	Adipose Subcutaneous	AP006621.5	0.33	0.24	enet	25	0.30	1.9e-24	-5.4	-5.5	3.6e-08	-0.67	0.99	0.01	FALSE
21	GTEx	Brain Cerebellum	TSPAN4	0.21	0.08	enet	15	0.08	1.9e-03	5.8	5.5	3.7e-08	0.61	0.14	0.08	FALSE
16	GTEx	Artery Coronary	AP006621.5	0.41	0.33	lasso	8	0.36	5.1e-13	-5.4	-5.5	4.2e-08	-0.77	0.46	0.54	FALSE
1	CommonMind	Brain Pre-frontal Cortex	AP2A2	0.09	0.04	enet	30	0.07	1.9e-08	-4.1	5.5	4.5e-08	0.41	1.00	0.00	FALSE
73	GTEx	Whole Blood	AP006621.6	0.11	0.04	lasso	3	0.06	3.4e-06	7.2	-5.5	4.6e-08	-0.88	0.01	0.99	FALSE
52	GTEx	Lung	PIDD	0.19	0.19	lasso	3	0.18	6.3e-14	-6.2	-5.5	4.7e-08	-0.78	0.77	0.23	FALSE
88	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CHID1	0.19	0.07	blup	67	0.08	8.9e-05	-3.3	5.5	4.8e-08	0.60	0.07	0.34	FALSE
55	GTEx	Muscle Skeletal	AP006621.5	0.09	0.10	lasso	2	0.09	9.9e-09	-5.4	-5.5	4.9e-08	-0.74	0.30	0.70	FALSE
40	GTEx	Esophagus Gastroesophageal Junction	AP006621.1	0.50	0.40	lasso	7	0.43	3.4e-17	-5.4	-5.4	5.4e-08	-0.76	0.89	0.11	FALSE
17	GTEx	Artery Tibial	AP006621.1	0.50	0.43	enet	26	0.42	2.5e-35	-5.4	-5.4	5.5e-08	-0.74	1.00	0.00	FALSE
48	GTEx	Heart Atrial Appendage	AP006621.5	0.36	0.21	lasso	4	0.24	2.2e-11	5.6	-5.4	5.7e-08	-0.78	0.92	0.08	FALSE
41	GTEx	Esophagus Gastroesophageal Junction	AP006621.6	0.33	0.21	lasso	4	0.20	9.3e-08	-6.1	-5.4	5.8e-08	-0.75	0.83	0.15	FALSE
95	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEND1	0.02	0.01	blup	52	0.01	2.8e-02	-3.6	-5.4	5.9e-08	-0.79	0.04	0.56	FALSE
94	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CHID1	0.10	0.07	lasso	5	0.05	4.1e-03	5.8	5.4	6.3e-08	0.53	0.09	0.08	FALSE
58	GTEx	Nerve Tibial	AP006621.5	0.40	0.29	enet	11	0.34	5.3e-25	-5.4	-5.4	8.6e-08	-0.72	0.99	0.01	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	AP006621.5	0.37	0.38	lasso	4	0.41	3.1e-57	-5.4	-5.3	9.1e-08	-0.72	1.00	0.00	FALSE
57	GTEx	Nerve Tibial	AP006621.6	0.30	0.22	enet	10	0.23	4.2e-16	-5.4	-5.3	9.3e-08	-0.72	0.97	0.03	FALSE
19	GTEx	Artery Tibial	AP006621.5	0.37	0.37	enet	18	0.37	1.9e-30	-5.4	-5.3	1.1e-07	-0.73	1.00	0.00	FALSE
25	GTEx	Brain Hippocampus	AP006621.5	0.26	0.22	enet	20	0.15	2.1e-04	-3.7	-5.3	1.3e-07	-0.60	0.13	0.21	FALSE
64	GTEx	Spleen	AP006621.5	0.44	0.42	lasso	2	0.41	1.2e-11	-5.4	-5.3	1.3e-07	-0.73	0.77	0.22	FALSE
89	The Cancer Genome Atlas	Lung Adenocarcinoma	EFCAB4A	0.04	0.02	lasso	2	0.04	3.0e-05	5.6	-5.3	1.3e-07	-0.74	0.03	0.88	FALSE
18	GTEx	Artery Tibial	AP006621.6	0.24	0.18	lasso	4	0.20	1.6e-15	-5.4	-5.3	1.4e-07	-0.74	0.97	0.03	FALSE
29	GTEx	Brain Putamen basal ganglia	AP006621.5	0.56	0.26	lasso	11	0.31	3.1e-08	-5.4	-5.3	1.4e-07	-0.72	0.05	0.79	FALSE
43	GTEx	Esophagus Mucosa	PIDD	0.26	0.17	lasso	4	0.18	5.5e-12	-6.2	-5.3	1.5e-07	-0.77	0.79	0.21	FALSE
27	GTEx	Brain Nucleus accumbens basal ganglia	AP006621.1	0.70	0.42	lasso	8	0.42	2.0e-12	-5.4	-5.2	1.6e-07	-0.75	0.58	0.40	FALSE
30	GTEx	Breast Mammary Tissue	AP006621.6	0.40	0.30	lasso	7	0.28	6.4e-15	-5.4	-5.2	1.6e-07	-0.75	0.92	0.08	FALSE
61	GTEx	Prostate	AP006621.5	0.34	0.31	lasso	3	0.28	8.3e-08	-5.4	-5.2	1.6e-07	-0.73	0.26	0.66	FALSE
45	GTEx	Esophagus Muscularis	AP006621.1	0.52	0.50	lasso	6	0.56	1.2e-40	-5.4	-5.2	1.7e-07	-0.75	0.93	0.07	FALSE
9	GTEx	Adipose Visceral Omentum	AP006621.1	0.37	0.29	enet	14	0.30	6.3e-16	-5.4	-5.2	2.0e-07	-0.74	0.97	0.03	FALSE
28	GTEx	Brain Putamen basal ganglia	AP006621.1	0.54	0.40	lasso	8	0.39	2.8e-10	-5.4	-5.2	2.0e-07	-0.77	0.07	0.92	FALSE
44	GTEx	Esophagus Mucosa	AP006621.5	0.32	0.21	enet	13	0.26	3.2e-17	-5.4	-5.2	2.0e-07	-0.77	0.90	0.10	FALSE
65	GTEx	Stomach	AP006621.1	0.55	0.46	lasso	7	0.46	2.3e-24	-5.4	-5.2	2.0e-07	-0.73	0.99	0.01	FALSE
22	GTEx	Brain Cortex	AP006621.5	0.35	0.17	lasso	5	0.23	6.5e-07	-5.4	-5.2	2.1e-07	-0.70	0.15	0.80	FALSE
39	GTEx	Colon Transverse	AP006621.5	0.41	0.34	enet	39	0.37	8.7e-19	-5.4	-5.2	2.1e-07	-0.71	0.93	0.07	FALSE
7	GTEx	Adipose Subcutaneous	AP006621.6	0.20	0.15	enet	16	0.15	1.7e-12	-5.4	-5.2	2.2e-07	-0.70	0.99	0.01	FALSE
14	GTEx	Artery Aorta	AP006621.5	0.35	0.34	enet	18	0.35	4.5e-20	-5.4	-5.2	2.4e-07	-0.72	0.99	0.01	FALSE
53	GTEx	Lung	AP006621.6	0.24	0.20	lasso	7	0.19	1.7e-14	-5.4	-5.2	2.6e-07	-0.73	0.94	0.06	FALSE
34	GTEx	Cells EBV-transformed lymphocytes	TSPAN4	0.22	0.05	lasso	6	0.02	6.0e-02	5.9	5.1	2.7e-07	0.47	0.07	0.24	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CDHR5	0.04	0.01	bslmm	472	0.00	1.6e-01	-6.2	5.1	3.0e-07	0.65	0.02	0.89	FALSE
50	GTEx	Heart Left Ventricle	AP006621.5	0.24	0.18	enet	11	0.18	1.3e-09	-3.7	-5.1	3.0e-07	-0.75	0.68	0.32	FALSE