[Hub]/) : Traits : Impedance of leg (left) :

chr17:15,149,905-18,923,818

Best TWAS P=3.34e-11 · Best GWAS P=4.43e-11 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex TOM1L2 0.19 0.24 bslmm 425 0.24 2.4e-29 6.2 -6.1 8.2e-10 -0.95 0.02 0.98 FALSE
2 GTEx Adipose Subcutaneous TOM1L2 0.04 0.04 lasso 3 0.04 5.3e-04 6.2 -6.0 2.0e-09 -0.95 0.08 0.90 FALSE
3 GTEx Adipose Visceral Omentum TOM1L2 0.15 0.13 lasso 4 0.11 3.6e-06 6.2 -6.2 4.1e-10 -0.96 0.10 0.90 FALSE
4 GTEx Adrenal Gland SREBF1 0.17 0.11 lasso 4 0.09 3.5e-04 5.1 5.3 1.4e-07 0.79 0.12 0.34 FALSE
5 GTEx Artery Aorta TTC19 0.06 0.00 lasso 3 0.00 7.1e-01 4.8 -5.7 1.5e-08 0.08 0.08 0.32 TRUE
6 GTEx Artery Aorta AC122129.1 0.06 0.01 lasso 5 0.00 3.6e-01 6.2 -5.5 4.9e-08 -0.90 0.08 0.69 FALSE
7 GTEx Brain Caudate basal ganglia ALKBH5 0.12 0.00 lasso 6 0.03 4.4e-02 4.9 -5.7 1.6e-08 -0.74 0.14 0.35 FALSE
8 GTEx Brain Cerebellum TOM1L2 0.10 0.06 lasso 5 0.02 6.6e-02 6.3 -6.4 2.0e-10 -0.93 0.05 0.79 FALSE
9 GTEx Brain Frontal Cortex BA9 ZSWIM7 0.15 0.21 lasso 3 0.20 6.3e-06 5.2 5.1 2.9e-07 -0.08 0.04 0.95 FALSE
10 GTEx Breast Mammary Tissue ALKBH5 0.07 0.09 enet 6 0.08 6.1e-05 -4.8 -5.3 1.4e-07 -0.55 0.30 0.14 FALSE
11 GTEx Cells Transformed fibroblasts SREBF1 0.09 0.01 lasso 11 0.01 3.2e-02 5.8 5.6 1.9e-08 0.81 0.13 0.42 FALSE
12 GTEx Cells Transformed fibroblasts CCDC144B 0.06 0.02 enet 10 0.06 2.9e-05 -3.5 -5.4 6.8e-08 -0.46 0.38 0.32 FALSE
13 GTEx Cells Transformed fibroblasts TOM1L2 0.05 0.00 enet 14 0.00 2.8e-01 3.0 -5.6 2.7e-08 -0.71 0.06 0.74 FALSE
14 GTEx Colon Sigmoid RP11-258F1.1 0.09 0.01 lasso 13 0.00 2.1e-01 -4.8 -5.3 1.0e-07 -0.55 0.09 0.15 FALSE
15 GTEx Esophagus Mucosa ALKBH5 0.09 0.08 lasso 8 0.06 9.3e-05 -4.8 -5.3 1.1e-07 -0.49 0.41 0.12 FALSE
16 GTEx Esophagus Mucosa DRG2 0.06 0.00 enet 19 0.01 1.3e-01 5.1 -5.8 8.4e-09 -0.64 0.11 0.14 FALSE
17 GTEx Esophagus Mucosa LLGL1 0.38 0.39 lasso 6 0.39 8.0e-28 -5.2 -5.3 1.4e-07 -0.37 0.94 0.06 FALSE
18 GTEx Esophagus Muscularis TOM1L2 0.06 0.07 enet 12 0.05 4.3e-04 5.8 -6.0 2.5e-09 -0.88 0.21 0.77 FALSE
19 GTEx Heart Atrial Appendage AC122129.1 0.15 0.02 enet 9 0.08 1.4e-04 2.8 -5.4 5.4e-08 -0.57 0.16 0.48 FALSE
20 GTEx Liver PEMT 0.25 -0.01 enet 11 0.01 1.5e-01 -2.8 -5.4 7.0e-08 -0.50 0.06 0.19 FALSE
21 GTEx Lung TOM1L2 0.07 0.02 lasso 6 0.03 1.4e-03 5.8 -6.3 2.7e-10 -0.85 0.16 0.82 FALSE
22 GTEx Lung RP11-258F1.1 0.05 0.00 lasso 5 0.00 4.1e-01 5.0 -5.7 1.2e-08 -0.85 0.10 0.52 FALSE
23 GTEx Muscle Skeletal TOM1L2 0.08 0.11 lasso 6 0.10 5.3e-10 6.2 -6.4 1.3e-10 -0.98 0.04 0.96 FALSE
24 GTEx Muscle Skeletal AC122129.1 0.13 0.14 lasso 4 0.13 7.3e-13 6.0 -6.1 8.8e-10 -0.95 0.20 0.80 FALSE
25 GTEx Pancreas TTC19 0.12 0.09 enet 9 0.07 8.5e-04 4.7 -5.6 2.3e-08 0.09 0.13 0.64 FALSE
26 GTEx Pancreas ADORA2B 0.12 0.16 enet 9 0.14 1.5e-06 5.2 5.2 2.5e-07 -0.08 0.04 0.96 FALSE
27 GTEx Pituitary TOM1L2 0.43 0.20 enet 18 0.11 1.3e-03 -3.3 -5.2 1.6e-07 -0.86 0.14 0.86 FALSE
28 GTEx Skin Not Sun Exposed Suprapubic ADORA2B 0.15 0.13 lasso 3 0.12 3.8e-07 5.3 5.3 1.1e-07 -0.09 0.03 0.97 FALSE
29 GTEx Skin Sun Exposed Lower leg DRG2 0.06 0.07 lasso 4 0.08 6.5e-07 5.1 -5.6 2.0e-08 -0.79 0.24 0.75 FALSE
30 GTEx Spleen ADORA2B 0.23 0.27 enet 10 0.24 7.4e-07 4.8 5.5 4.6e-08 -0.08 0.05 0.94 FALSE
31 GTEx Testis ALKBH5 0.18 0.06 enet 14 0.11 1.3e-05 2.2 -5.9 3.9e-09 -0.59 0.21 0.66 FALSE
32 GTEx Whole Blood SREBF1 0.04 0.06 lasso 5 0.05 2.4e-05 6.2 -6.2 6.1e-10 -0.96 0.05 0.95 FALSE
33 GTEx Whole Blood ADORA2B 0.08 0.00 lasso 5 0.00 2.5e-01 3.8 5.4 6.5e-08 -0.05 0.04 0.68 FALSE
34 METSIM Adipose ALKBH5 0.08 0.05 blup 285 0.04 3.0e-07 -4.8 -5.4 6.3e-08 -0.54 0.98 0.02 FALSE
35 ROSMAP Brain Pre-frontal Cortex TOM1L2 0.15 0.11 blup 414 0.10 1.4e-12 6.2 -6.0 2.0e-09 -0.85 0.02 0.98 FALSE
36 YFS Blood PIGL 0.02 0.02 blup 279 0.02 1.5e-06 3.0 5.7 1.6e-08 -0.06 0.18 0.82 FALSE
37 YFS Blood SREBF1 0.07 0.11 lasso 7 0.11 2.2e-33 6.6 -6.6 3.3e-11 -0.98 0.01 0.99 TRUE
38 The Cancer Genome Atlas Breast Invasive Carcinoma TOM1L2 0.01 0.01 blup 83 0.01 1.8e-03 5.3 -6.1 1.2e-09 -0.95 0.05 0.85 FALSE
39 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma ADORA2B 0.28 0.24 enet 14 0.27 7.3e-16 4.7 5.5 3.2e-08 -0.07 0.02 0.97 FALSE
40 The Cancer Genome Atlas Brain Lower Grade Glioma ALKBH5 0.05 0.04 lasso 1 0.03 9.1e-05 -5.2 -5.2 1.9e-07 -0.36 0.00 0.99 FALSE
41 The Cancer Genome Atlas Liver Hepatocellular Carcinoma ADORA2B 0.13 0.17 blup 37 0.16 8.2e-08 4.9 5.5 4.7e-08 -0.07 0.01 0.98 FALSE
42 The Cancer Genome Atlas Lung Adenocarcinoma ZSWIM7 0.05 0.05 blup 48 0.05 3.3e-06 4.7 5.2 2.6e-07 -0.08 0.02 0.98 FALSE
43 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADORA2B 0.10 0.07 enet 9 0.08 5.0e-06 4.7 5.3 1.1e-07 -0.07 0.01 0.98 FALSE
44 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma LRRC48 0.07 0.05 enet 12 0.04 7.0e-03 5.8 5.7 1.6e-08 0.89 0.03 0.66 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma ZSWIM7 0.15 0.25 enet 13 0.26 2.0e-27 4.9 5.1 3.1e-07 -0.08 0.01 0.99 FALSE
46 The Cancer Genome Atlas Stomach Adenocarcinoma SREBF1 0.04 0.03 blup 32 0.02 7.8e-03 4.9 6.0 1.7e-09 0.94 0.02 0.66 FALSE