[Hub]/) : Traits : Impedance of leg (left) : ← →

chr17:15,149,905-18,923,818

Best TWAS P=3.34e-11 · Best GWAS P=4.43e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	YFS	Blood	SREBF1	0.07	0.11	lasso	7	0.11	2.2e-33	6.6	-6.6	3.3e-11	-0.98	0.01	0.99	TRUE
5	GTEx	Artery Aorta	TTC19	0.06	0.00	lasso	3	0.00	7.1e-01	4.8	-5.7	1.5e-08	0.08	0.08	0.32	TRUE
23	GTEx	Muscle Skeletal	TOM1L2	0.08	0.11	lasso	6	0.10	5.3e-10	6.2	-6.4	1.3e-10	-0.98	0.04	0.96	FALSE
8	GTEx	Brain Cerebellum	TOM1L2	0.10	0.06	lasso	5	0.02	6.6e-02	6.3	-6.4	2.0e-10	-0.93	0.05	0.79	FALSE
21	GTEx	Lung	TOM1L2	0.07	0.02	lasso	6	0.03	1.4e-03	5.8	-6.3	2.7e-10	-0.85	0.16	0.82	FALSE
3	GTEx	Adipose Visceral Omentum	TOM1L2	0.15	0.13	lasso	4	0.11	3.6e-06	6.2	-6.2	4.1e-10	-0.96	0.10	0.90	FALSE
32	GTEx	Whole Blood	SREBF1	0.04	0.06	lasso	5	0.05	2.4e-05	6.2	-6.2	6.1e-10	-0.96	0.05	0.95	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TOM1L2	0.19	0.24	bslmm	425	0.24	2.4e-29	6.2	-6.1	8.2e-10	-0.95	0.02	0.98	FALSE
24	GTEx	Muscle Skeletal	AC122129.1	0.13	0.14	lasso	4	0.13	7.3e-13	6.0	-6.1	8.8e-10	-0.95	0.20	0.80	FALSE
38	The Cancer Genome Atlas	Breast Invasive Carcinoma	TOM1L2	0.01	0.01	blup	83	0.01	1.8e-03	5.3	-6.1	1.2e-09	-0.95	0.05	0.85	FALSE
46	The Cancer Genome Atlas	Stomach Adenocarcinoma	SREBF1	0.04	0.03	blup	32	0.02	7.8e-03	4.9	6.0	1.7e-09	0.94	0.02	0.66	FALSE
2	GTEx	Adipose Subcutaneous	TOM1L2	0.04	0.04	lasso	3	0.04	5.3e-04	6.2	-6.0	2.0e-09	-0.95	0.08	0.90	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	TOM1L2	0.15	0.11	blup	414	0.10	1.4e-12	6.2	-6.0	2.0e-09	-0.85	0.02	0.98	FALSE
18	GTEx	Esophagus Muscularis	TOM1L2	0.06	0.07	enet	12	0.05	4.3e-04	5.8	-6.0	2.5e-09	-0.88	0.21	0.77	FALSE
31	GTEx	Testis	ALKBH5	0.18	0.06	enet	14	0.11	1.3e-05	2.2	-5.9	3.9e-09	-0.59	0.21	0.66	FALSE
16	GTEx	Esophagus Mucosa	DRG2	0.06	0.00	enet	19	0.01	1.3e-01	5.1	-5.8	8.4e-09	-0.64	0.11	0.14	FALSE
22	GTEx	Lung	RP11-258F1.1	0.05	0.00	lasso	5	0.00	4.1e-01	5.0	-5.7	1.2e-08	-0.85	0.10	0.52	FALSE
7	GTEx	Brain Caudate basal ganglia	ALKBH5	0.12	0.00	lasso	6	0.03	4.4e-02	4.9	-5.7	1.6e-08	-0.74	0.14	0.35	FALSE
36	YFS	Blood	PIGL	0.02	0.02	blup	279	0.02	1.5e-06	3.0	5.7	1.6e-08	-0.06	0.18	0.82	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC48	0.07	0.05	enet	12	0.04	7.0e-03	5.8	5.7	1.6e-08	0.89	0.03	0.66	FALSE
11	GTEx	Cells Transformed fibroblasts	SREBF1	0.09	0.01	lasso	11	0.01	3.2e-02	5.8	5.6	1.9e-08	0.81	0.13	0.42	FALSE
29	GTEx	Skin Sun Exposed Lower leg	DRG2	0.06	0.07	lasso	4	0.08	6.5e-07	5.1	-5.6	2.0e-08	-0.79	0.24	0.75	FALSE
25	GTEx	Pancreas	TTC19	0.12	0.09	enet	9	0.07	8.5e-04	4.7	-5.6	2.3e-08	0.09	0.13	0.64	FALSE
13	GTEx	Cells Transformed fibroblasts	TOM1L2	0.05	0.00	enet	14	0.00	2.8e-01	3.0	-5.6	2.7e-08	-0.71	0.06	0.74	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ADORA2B	0.28	0.24	enet	14	0.27	7.3e-16	4.7	5.5	3.2e-08	-0.07	0.02	0.97	FALSE
30	GTEx	Spleen	ADORA2B	0.23	0.27	enet	10	0.24	7.4e-07	4.8	5.5	4.6e-08	-0.08	0.05	0.94	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ADORA2B	0.13	0.17	blup	37	0.16	8.2e-08	4.9	5.5	4.7e-08	-0.07	0.01	0.98	FALSE
6	GTEx	Artery Aorta	AC122129.1	0.06	0.01	lasso	5	0.00	3.6e-01	6.2	-5.5	4.9e-08	-0.90	0.08	0.69	FALSE
19	GTEx	Heart Atrial Appendage	AC122129.1	0.15	0.02	enet	9	0.08	1.4e-04	2.8	-5.4	5.4e-08	-0.57	0.16	0.48	FALSE
34	METSIM	Adipose	ALKBH5	0.08	0.05	blup	285	0.04	3.0e-07	-4.8	-5.4	6.3e-08	-0.54	0.98	0.02	FALSE
33	GTEx	Whole Blood	ADORA2B	0.08	0.00	lasso	5	0.00	2.5e-01	3.8	5.4	6.5e-08	-0.05	0.04	0.68	FALSE
12	GTEx	Cells Transformed fibroblasts	CCDC144B	0.06	0.02	enet	10	0.06	2.9e-05	-3.5	-5.4	6.8e-08	-0.46	0.38	0.32	FALSE
20	GTEx	Liver	PEMT	0.25	-0.01	enet	11	0.01	1.5e-01	-2.8	-5.4	7.0e-08	-0.50	0.06	0.19	FALSE
14	GTEx	Colon Sigmoid	RP11-258F1.1	0.09	0.01	lasso	13	0.00	2.1e-01	-4.8	-5.3	1.0e-07	-0.55	0.09	0.15	FALSE
15	GTEx	Esophagus Mucosa	ALKBH5	0.09	0.08	lasso	8	0.06	9.3e-05	-4.8	-5.3	1.1e-07	-0.49	0.41	0.12	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	ADORA2B	0.15	0.13	lasso	3	0.12	3.8e-07	5.3	5.3	1.1e-07	-0.09	0.03	0.97	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ADORA2B	0.10	0.07	enet	9	0.08	5.0e-06	4.7	5.3	1.1e-07	-0.07	0.01	0.98	FALSE
4	GTEx	Adrenal Gland	SREBF1	0.17	0.11	lasso	4	0.09	3.5e-04	5.1	5.3	1.4e-07	0.79	0.12	0.34	FALSE
10	GTEx	Breast Mammary Tissue	ALKBH5	0.07	0.09	enet	6	0.08	6.1e-05	-4.8	-5.3	1.4e-07	-0.55	0.30	0.14	FALSE
17	GTEx	Esophagus Mucosa	LLGL1	0.38	0.39	lasso	6	0.39	8.0e-28	-5.2	-5.3	1.4e-07	-0.37	0.94	0.06	FALSE
27	GTEx	Pituitary	TOM1L2	0.43	0.20	enet	18	0.11	1.3e-03	-3.3	-5.2	1.6e-07	-0.86	0.14	0.86	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	ALKBH5	0.05	0.04	lasso	1	0.03	9.1e-05	-5.2	-5.2	1.9e-07	-0.36	0.00	0.99	FALSE
26	GTEx	Pancreas	ADORA2B	0.12	0.16	enet	9	0.14	1.5e-06	5.2	5.2	2.5e-07	-0.08	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	ZSWIM7	0.05	0.05	blup	48	0.05	3.3e-06	4.7	5.2	2.6e-07	-0.08	0.02	0.98	FALSE
9	GTEx	Brain Frontal Cortex BA9	ZSWIM7	0.15	0.21	lasso	3	0.20	6.3e-06	5.2	5.1	2.9e-07	-0.08	0.04	0.95	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZSWIM7	0.15	0.25	enet	13	0.26	2.0e-27	4.9	5.1	3.1e-07	-0.08	0.01	0.99	FALSE