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chr17:923,916-3,287,175

Best TWAS P=2.37e-24 · Best GWAS P=7.21e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
81	The Cancer Genome Atlas	Skin Cutaneous Melanoma	SRR	0.16	0.03	blup	61	0.02	8.7e-02	6.75	-10.2	2.4e-24	0.83	0.01	0.62	TRUE
4	GTEx	Adrenal Gland	SRR	0.38	0.37	lasso	6	0.38	8.1e-15	6.17	-7.8	4.5e-15	0.70	0.75	0.25	TRUE
51	METSIM	Adipose	SERPINF1	0.06	0.00	bslmm	450	0.02	2.5e-04	2.04	-7.2	5.8e-13	0.44	0.18	0.13	TRUE
82	The Cancer Genome Atlas	Stomach Adenocarcinoma	LOC284009	0.09	0.00	blup	59	0.00	2.3e-01	5.53	-7.2	6.5e-13	0.26	0.02	0.23	TRUE
52	METSIM	Adipose	SRR	0.07	0.07	enet	21	0.06	4.4e-09	6.17	-7.0	2.7e-12	0.61	1.00	0.00	TRUE
42	GTEx	Skin Sun Exposed Lower leg	TSR1	0.20	0.05	enet	24	0.06	5.4e-06	-7.09	6.8	1.4e-11	-0.47	0.82	0.08	TRUE
38	GTEx	Skin Not Sun Exposed Suprapubic	MNT	0.16	0.06	lasso	7	0.04	2.6e-03	-5.33	-5.8	6.4e-09	0.36	0.17	0.10	TRUE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	PAFAH1B1	0.11	0.00	blup	61	0.04	3.6e-03	0.23	5.5	3.1e-08	-0.06	0.01	0.37	TRUE
49	GTEx	Thyroid	WDR81	0.15	0.03	lasso	7	0.03	1.7e-03	5.54	-5.5	3.4e-08	0.01	0.31	0.02	TRUE
15	GTEx	Cells EBV-transformed lymphocytes	MNT	0.42	0.10	lasso	9	0.14	3.0e-05	6.01	-8.7	4.7e-18	0.40	0.34	0.08	FALSE
61	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SRR	0.15	0.11	blup	61	0.07	4.0e-04	6.17	-8.5	2.6e-17	0.56	0.25	0.18	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	MNT	0.09	0.04	lasso	5	0.06	9.5e-09	7.14	-8.3	7.3e-17	0.35	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SMG6	0.08	0.05	blup	144	0.07	1.3e-04	-9.52	-8.3	1.2e-16	0.83	0.11	0.82	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	SMG6	0.03	0.01	blup	144	0.01	4.8e-03	-8.21	-8.1	7.6e-16	0.83	0.05	0.79	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	MNT	0.03	0.01	enet	7	0.02	1.7e-03	-5.33	-7.7	2.0e-14	0.41	0.06	0.42	FALSE
85	The Cancer Genome Atlas	Testicular Germ Cell Tumors	SGSM2	0.13	0.01	blup	81	0.01	1.1e-01	-9.85	7.5	4.3e-14	-0.78	0.01	0.67	FALSE
2	GTEx	Adipose Subcutaneous	SRR	0.16	0.16	lasso	9	0.18	1.9e-14	6.44	-7.5	9.1e-14	0.66	1.00	0.00	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	RP1-59D14.1	0.22	0.01	lasso	4	0.01	1.3e-01	6.01	-7.5	9.6e-14	0.39	0.07	0.11	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC284009	0.02	0.01	blup	59	0.01	1.4e-02	5.53	-7.2	6.0e-13	0.32	0.03	0.06	FALSE
25	GTEx	Esophagus Mucosa	RP1-59D14.5	0.14	0.15	lasso	2	0.14	1.3e-09	-7.09	7.1	1.5e-12	-0.54	0.99	0.00	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SRR	0.30	0.40	lasso	7	0.39	8.5e-47	6.44	-7.1	1.7e-12	0.59	1.00	0.00	FALSE
23	GTEx	Esophagus Mucosa	SGSM2	0.28	0.32	lasso	5	0.32	6.9e-22	-7.09	7.0	1.8e-12	-0.54	1.00	0.00	FALSE
21	GTEx	Colon Transverse	RP1-59D14.5	0.22	0.14	lasso	3	0.11	4.5e-06	-6.93	-6.9	4.5e-12	0.38	0.49	0.03	FALSE
11	GTEx	Brain Frontal Cortex BA9	SRR	0.25	0.24	lasso	3	0.21	3.5e-06	6.17	-6.8	7.2e-12	0.56	0.26	0.09	FALSE
47	GTEx	Testis	SMG6	0.28	0.07	enet	39	0.14	1.2e-06	6.17	6.8	9.5e-12	-0.49	0.40	0.51	FALSE
75	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SRR	0.16	0.20	lasso	3	0.20	2.8e-13	6.45	-6.8	1.2e-11	0.56	1.00	0.00	FALSE
64	The Cancer Genome Atlas	Esophageal Carcinoma	SRR	0.32	0.13	lasso	2	0.16	9.2e-06	6.75	-6.8	1.5e-11	0.56	0.31	0.47	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	SRR	0.32	0.24	lasso	3	0.23	1.5e-13	6.17	-6.7	2.2e-11	0.54	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SRR	0.27	0.19	enet	5	0.21	8.9e-09	6.45	-6.7	2.2e-11	0.55	0.62	0.37	FALSE
48	GTEx	Testis	SRR	0.13	0.12	lasso	2	0.09	6.6e-05	6.75	-6.7	2.9e-11	0.56	0.39	0.34	FALSE
71	The Cancer Genome Atlas	Brain Lower Grade Glioma	SRR	0.29	0.26	lasso	2	0.27	1.9e-30	6.44	-6.6	3.5e-11	0.54	1.00	0.00	FALSE
14	GTEx	Breast Mammary Tissue (Female)	SRR	0.24	0.25	lasso	3	0.21	6.3e-07	6.50	-6.6	4.8e-11	0.55	0.70	0.13	FALSE
45	GTEx	Spleen	SRR	0.21	0.10	lasso	4	0.04	3.1e-02	6.17	-6.6	4.9e-11	0.56	0.07	0.49	FALSE
24	GTEx	Esophagus Mucosa	SRR	0.23	0.24	lasso	5	0.24	2.0e-16	6.45	-6.5	6.3e-11	0.55	1.00	0.00	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	SRR	0.16	0.16	lasso	5	0.16	2.3e-32	6.44	-6.5	7.1e-11	0.54	1.00	0.00	FALSE
76	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SRR	0.34	0.30	lasso	4	0.30	2.9e-13	6.17	-6.5	8.3e-11	0.54	1.00	0.00	FALSE
34	GTEx	Muscle Skeletal	METTL16	0.19	0.06	enet	22	0.07	1.0e-07	5.51	6.5	8.6e-11	-0.22	0.91	0.00	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	SRR	0.25	0.39	lasso	3	0.39	5.6e-53	6.17	-6.5	9.0e-11	0.55	1.00	0.00	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	SRR	0.39	0.34	lasso	5	0.35	3.1e-12	6.17	-6.4	1.3e-10	0.54	0.99	0.01	FALSE
19	GTEx	Colon Sigmoid	SRR	0.32	0.35	enet	8	0.32	9.2e-12	6.17	-6.4	1.3e-10	0.53	1.00	0.00	FALSE
37	GTEx	Pancreas	SRR	0.13	0.17	lasso	3	0.15	5.2e-07	6.45	-6.4	1.6e-10	0.53	0.93	0.03	FALSE
3	GTEx	Adipose Visceral Omentum	SRR	0.29	0.26	lasso	5	0.25	1.8e-13	6.17	-6.4	1.8e-10	0.52	1.00	0.00	FALSE
80	The Cancer Genome Atlas	Soft Tissue Sarcoma	SRR	0.20	0.18	lasso	2	0.20	8.8e-12	6.17	-6.4	1.8e-10	0.53	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	SRR	0.30	0.35	lasso	3	0.36	7.5e-39	6.17	-6.4	2.1e-10	0.53	1.00	0.00	FALSE
72	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SRR	0.08	0.09	enet	3	0.08	1.7e-04	6.17	-6.3	2.5e-10	0.52	0.15	0.22	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SRR	0.10	0.10	lasso	2	0.09	1.0e-10	6.17	-6.3	2.7e-10	0.52	1.00	0.00	FALSE
73	The Cancer Genome Atlas	Lung Adenocarcinoma	SRR	0.14	0.18	lasso	2	0.18	4.3e-21	6.17	-6.3	2.7e-10	0.52	1.00	0.00	FALSE
44	GTEx	Skin Sun Exposed Lower leg	RP1-59D14.5	0.32	0.28	lasso	5	0.30	1.8e-25	-7.09	6.3	3.1e-10	-0.50	1.00	0.00	FALSE
56	YFS	Blood	SRR	0.17	0.22	lasso	7	0.23	2.5e-72	6.17	-6.3	3.2e-10	0.51	1.00	0.00	FALSE
46	GTEx	Stomach	SRR	0.27	0.30	lasso	7	0.28	7.1e-14	6.40	-6.3	3.4e-10	0.52	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SRR	0.11	0.12	lasso	2	0.12	4.3e-13	6.17	-6.3	3.4e-10	0.52	1.00	0.00	FALSE
18	GTEx	Cells Transformed fibroblasts	SRR	0.36	0.38	lasso	4	0.38	8.2e-30	6.17	-6.3	3.5e-10	0.52	1.00	0.00	FALSE
10	GTEx	Brain Cerebellum	SRR	0.26	0.20	lasso	3	0.21	8.7e-07	6.17	-6.2	4.3e-10	0.53	0.38	0.04	FALSE
5	GTEx	Artery Aorta	SRR	0.33	0.33	lasso	2	0.32	6.1e-18	6.17	-6.2	4.4e-10	0.52	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SRR	0.22	0.23	lasso	2	0.21	2.3e-12	6.17	-6.2	5.1e-10	0.51	1.00	0.00	FALSE
50	GTEx	Thyroid	SRR	0.26	0.27	lasso	4	0.25	2.0e-19	6.17	-6.2	5.5e-10	0.52	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	SRR	0.27	0.48	lasso	1	0.48	3.5e-65	6.17	-6.2	7.0e-10	0.51	1.00	0.00	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	SRR	0.24	0.16	lasso	1	0.13	9.0e-05	6.17	-6.2	7.0e-10	0.51	0.09	0.31	FALSE
40	GTEx	Skin Sun Exposed Lower leg	SGSM2	0.50	0.47	enet	11	0.51	3.3e-48	-7.09	6.1	8.0e-10	-0.48	1.00	0.00	FALSE
31	GTEx	Lung	SRR	0.24	0.28	lasso	2	0.26	3.4e-20	6.17	-6.1	8.6e-10	0.52	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Thyroid Carcinoma	SRR	0.56	0.50	lasso	4	0.50	5.2e-55	6.17	-6.1	1.0e-09	0.51	1.00	0.00	FALSE
22	GTEx	Esophagus Gastroesophageal Junction	SRR	0.40	0.35	lasso	3	0.36	1.1e-13	6.17	-6.1	1.1e-09	0.50	1.00	0.00	FALSE
8	GTEx	Artery Tibial	SRR	0.22	0.23	lasso	4	0.24	3.9e-19	6.44	-6.0	1.4e-09	0.50	1.00	0.00	FALSE
26	GTEx	Esophagus Muscularis	SRR	0.30	0.39	lasso	3	0.38	3.4e-24	6.17	-6.0	1.4e-09	0.50	1.00	0.00	FALSE
7	GTEx	Artery Tibial	SGSM2	0.12	0.02	enet	11	0.05	1.6e-04	5.67	-6.0	1.7e-09	0.46	0.22	0.51	FALSE
12	GTEx	Brain Frontal Cortex BA9	HNRNPA1P16	0.22	-0.01	enet	25	0.06	8.6e-03	6.41	-6.0	1.8e-09	0.36	0.07	0.14	FALSE
20	GTEx	Colon Transverse	SRR	0.28	0.21	lasso	5	0.19	1.6e-09	6.17	-6.0	1.8e-09	0.52	0.99	0.01	FALSE
9	GTEx	Artery Tibial	RP1-59D14.5	0.17	0.13	lasso	5	0.09	2.9e-07	-6.93	-6.0	1.9e-09	0.37	1.00	0.00	FALSE
36	GTEx	Nerve Tibial	SRR	0.15	0.13	lasso	3	0.13	2.9e-09	6.44	-5.9	3.3e-09	0.48	1.00	0.00	FALSE
30	GTEx	Lung	MNT	0.14	0.05	lasso	5	0.04	3.8e-04	-5.42	-5.8	5.2e-09	0.37	0.77	0.01	FALSE
29	GTEx	Heart Left Ventricle	SRR	0.15	0.16	lasso	3	0.13	2.9e-07	6.17	-5.8	6.1e-09	0.51	0.97	0.00	FALSE
35	GTEx	Muscle Skeletal	SRR	0.27	0.27	lasso	6	0.27	7.1e-27	6.17	-5.8	7.3e-09	0.48	1.00	0.00	FALSE
83	The Cancer Genome Atlas	Stomach Adenocarcinoma	SRR	0.21	0.15	enet	11	0.16	1.1e-11	6.44	-5.7	1.3e-08	0.52	1.00	0.00	FALSE
55	YFS	Blood	SGSM2	0.05	0.03	lasso	8	0.03	3.9e-11	3.76	-5.6	1.6e-08	0.26	1.00	0.00	FALSE
43	GTEx	Skin Sun Exposed Lower leg	RP1-59D14.1	0.11	0.07	lasso	4	0.06	1.8e-05	-5.33	-5.6	1.9e-08	0.34	0.85	0.01	FALSE
6	GTEx	Artery Coronary	SRR	0.44	0.28	lasso	8	0.26	2.5e-09	6.44	-5.6	2.0e-08	0.49	0.98	0.01	FALSE
41	GTEx	Skin Sun Exposed Lower leg	SRR	0.13	0.15	lasso	4	0.14	2.0e-11	6.17	-5.6	2.4e-08	0.47	1.00	0.00	FALSE
32	GTEx	Lung	RP1-59D14.1	0.08	0.03	lasso	2	0.01	8.6e-02	-5.42	-5.6	2.6e-08	0.34	0.12	0.03	FALSE
13	GTEx	Breast Mammary Tissue	SRR	0.20	0.21	lasso	3	0.20	8.2e-11	6.50	-5.5	2.9e-08	0.50	1.00	0.00	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	LOC284009	0.07	0.03	lasso	4	0.05	1.2e-05	5.51	-5.5	2.9e-08	0.20	0.16	0.07	FALSE
84	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LOC284009	0.14	0.10	lasso	3	0.08	1.2e-03	5.53	-5.5	3.1e-08	0.20	0.06	0.23	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	LOC284009	0.06	0.04	lasso	5	0.03	5.5e-04	5.53	-5.4	5.6e-08	0.20	0.35	0.05	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	METT10D	0.04	0.00	blup	84	0.02	4.2e-03	6.64	5.4	5.9e-08	-0.35	0.04	0.16	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	SGSM2	0.37	0.35	enet	18	0.41	6.6e-24	-7.09	5.3	1.0e-07	-0.46	1.00	0.00	FALSE
28	GTEx	Heart Atrial Appendage	SRR	0.35	0.30	lasso	7	0.29	1.4e-13	6.45	-5.3	1.4e-07	0.44	1.00	0.00	FALSE
27	GTEx	Esophagus Muscularis	RP11-667K14.4	0.12	0.03	lasso	6	0.03	8.1e-03	-1.58	5.3	1.5e-07	-0.40	0.19	0.09	FALSE
33	GTEx	Muscle Skeletal	PAFAH1B1	0.17	0.05	lasso	7	0.04	6.5e-05	4.61	5.2	2.0e-07	-0.13	0.92	0.00	FALSE