TWAS hub - PEMT

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.1720	0.0480	4.2e-06	0.134	NA	0.122	NA	0.086	4.7e-11	NA	3.6e-10	NA	1.5e-07
2	GTEx	Cells Transformed fibroblasts	0.0910	0.0410	3.8e-04	0.017	NA	0.051	NA	0.030	1.7e-02	NA	1.0e-04	NA	2.4e-03
3	GTEx	Heart Atrial Appendage	0.2170	0.0840	6.5e-03	0.081	NA	0.029	NA	0.046	1.7e-04	NA	1.8e-02	NA	3.8e-03
4	GTEx	Liver	0.2540	0.1140	9.2e-03	-0.010	NA	0.011	NA	0.001	9.0e-01	NA	1.5e-01	NA	3.1e-01
5	METSIM	Adipose	0.1265	0.0302	4.4e-12	0.095	0.078	0.107	0.087	0.111	5.0e-14	8.7e-12	1.1e-15	6.1e-13	2.6e-16
6	TCGA	Breast Invasive Carcinoma	0.0154	0.0090	1.2e-03	0.006	0.014	0.020	NA	0.012	1.5e-02	5.8e-04	5.2e-05	NA	1.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Waist Hip Ratio (WHR)	12.7	57.2	98.8	8.5	8.2	5.0	1.4	8.9	9.9
Birth weight of first child	9.2	16.8	28.6	-3.4	-5.0	-5.2	-0.8	-2.9	-5.4
Hayfever/allergic rhinitis (self-reported)	7.0	9.3	21.0	-3.0	-1.1	-3.1	-4.6	-3.1	-2.2
Coronary Artery Disease (CAD)	6.3	7.6	14.2	2.6	3.6	2.5	-0.7	2.3	3.8
Gout (self-reported)	5.8	7.9	9.7	2.8	2.9	3.1	2.8	2.4	2.8
Age when periods started (menarche)	5.2	12.5	21.5	3.7	3.9	3.5	0.5	3.5	4.6
Glaucoma (self-reported)	4.0	4.7	6.5	-2.6	-1.0	-2.3	-2.4	-2.5	-1.9
Medication: Allopurinol	3.9	5.2	7.6	2.0	2.5	2.8	2.2	1.2	2.6
Mother’s age at death	3.8	4.8	8.0	-2.8	-2.7	-1.6	-0.9	-2.5	-1.9
Medication: Omeprazole	3.6	4.2	7.5	-1.8	-2.7	-2.6	-0.1	-2.0	-1.9
Eye problems/disorders: Glaucoma	3.6	4.3	6.1	-2.4	-1.1	-1.8	-2.5	-2.5	-1.8
Supplements: Zinc	3.4	3.7	8.0	-1.4	-2.8	-2.8	-0.3	-1.3	-1.7
Triglycerides	3.0	5.0	9.4	2.6	2.5	0.7	0.8	3.1	2.5
Osteoporosis (self-reported)	3.0	3.7	8.4	-1.5	-2.9	-1.1	1.1	-1.1	-2.9
Cholesterol lowering medication	3.0	4.5	10.1	2.8	0.5	0.8	2.1	3.2	2.0
Allergy or Eczema	2.9	7.6	33.8	-1.8	-0.7	-2.5	-5.8	-1.2	-0.6
Supplements: Calcium	2.9	3.2	4.3	-2.1	-1.8	-1.8	-0.4	-2.0	-2.1
Hayfever, allergic rhinitis or eczema	2.5	5.4	23.4	-1.5	-0.7	-2.1	-4.8	-0.9	-0.8
Heart attack	2.5	3.1	7.2	0.8	2.7	1.6	-1.9	0.5	2.2
Hip circumference	2.5	10.9	17.5	-3.4	-4.2	-2.6	0.3	-3.7	-4.1
Suffer from ‘nerves’	2.5	4.0	8.4	2.0	2.1	2.3	-0.1	1.3	2.9
Overall health rating	2.4	5.2	9.2	0.6	2.7	2.5	-2.8	0.0	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.4	2.9	7.3	-1.2	-2.7	-1.4	0.3	-1.2	-2.3
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	5.9	-1.6	-2.3	-2.4	-0.2	-1.5	-1.2
Heart attack/myocardial infarction (self-reported)	2.4	3.1	8.0	1.0	2.8	1.8	-1.6	0.7	1.9
Reaction Time	2.3	4.4	14.6	-0.3	3.8	0.9	-3.3	-0.3	0.5
Fluid intelligence score	2.3	4.7	10.7	-1.3	-3.3	-1.0	2.7	-0.6	-2.7
Alcohol drinker status: Never	2.3	2.8	4.9	-1.9	-1.4	-2.2	-1.5	-1.4	-1.4
Average weekly spirits intake	2.2	2.8	5.1	0.4	2.2	2.0	-1.7	0.1	2.3
Ever had hysterectomy (womb removed)	2.2	2.5	3.4	-1.8	-0.5	-1.9	-1.7	-1.6	-1.6
Hair/balding pattern: Pattern 2	2.2	2.8	9.1	-1.6	1.6	0.6	-3.0	-1.3	0.9
Pulse wave reflection index	2.2	2.7	10.4	1.6	-0.9	0.6	3.2	1.3	-0.7
Crohns Disease (2012)	2.1	3.4	5.1	2.3	1.7	1.9	1.4	2.2	1.5
Eye problems/disorders: None of the above	2.1	2.4	4.2	1.9	0.5	1.6	1.9	2.1	-0.0
Impedance of leg (left)	2.0	9.7	29.1	-1.2	3.4	2.2	-5.4	-1.4	3.1
Forced expiratory volume in 1-second (FEV1)	2.0	6.7	13.8	3.3	1.0	1.5	3.7	3.4	0.5
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	4.8	-1.5	-1.6	-1.5	-0.7	-2.2	-1.8
Headache pain in last month	2.0	3.4	7.9	0.5	2.8	1.0	-1.7	1.1	2.6
Health satisfaction	2.0	2.6	6.2	0.3	1.6	1.5	-2.5	-0.4	2.1
Schizophrenia (2014)	1.9	4.3	17.5	-0.8	2.3	-0.4	-4.2	-1.3	0.7
Alcohol usually taken with meals	1.9	3.1	6.6	-0.9	2.0	1.3	-2.6	-1.4	1.9
Pulse rate	1.9	3.2	6.5	1.1	2.5	0.8	-2.2	0.9	2.3
Trunk predicted mass	1.9	10.8	24.2	4.4	-0.2	-0.1	4.9	4.5	-0.5
Mean time to correctly identify matches	1.9	3.6	13.2	-0.3	3.6	0.5	-2.8	-0.2	0.1
Schizophrenia (2018)	1.8	3.8	16.0	-0.8	2.1	-0.3	-4.0	-1.0	0.7
Major Depression (MDD)	1.8	2.2	3.8	-1.2	-1.6	-1.9	-0.2	-1.8	-1.4
Lung FEV1/FVC ratio	1.8	9.0	15.2	3.4	3.7	1.2	-0.3	3.9	3.5
Impedance of leg (right)	1.8	8.5	21.4	-0.7	3.5	2.0	-4.6	-0.9	3.5
Allergy	1.8	4.1	18.6	1.6	0.7	1.4	4.3	0.8	0.7
Diabetes (self-reported)	1.8	2.9	9.5	-0.4	1.4	-0.5	-3.1	-1.0	2.0
Trunk fat-free mass	1.8	10.4	23.2	4.4	-0.2	-0.1	4.8	4.4	-0.6
Emphysema/chronic bronchitis	1.8	2.1	3.2	-1.8	-0.1	-1.5	-1.5	-1.7	-1.4
Miserableness	1.8	3.2	5.8	1.2	2.0	2.4	1.0	1.1	2.4
Bipolar Disorder or Schizophrenia	1.7	4.1	18.2	-1.5	1.3	-0.7	-4.3	-1.4	0.0
Intelligence (Savage-Jansen 2018)	1.7	5.1	12.7	-0.3	-3.6	-1.2	3.4	0.5	-2.1
Ovarian Cancer	1.7	2.3	6.1	-1.8	-0.3	-0.4	-2.5	-1.9	-0.6
HbA1C	1.7	1.9	3.8	1.5	1.9	0.1	-0.8	1.9	1.2
HDL Cholesterol	1.7	2.8	7.4	-2.1	-1.0	-0.6	-1.5	-2.7	-1.2
Blood White Count	1.7	12.3	24.9	2.7	4.9	0.7	-5.0	2.4	3.3
Diabetes (father)	1.7	2.1	5.6	-1.6	0.2	-0.6	-2.4	-2.0	-0.4
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	4.9	1.1	-1.3	-0.6	2.2	1.4	-1.1
Forced vital capacity (FVC)	1.7	6.7	21.7	2.7	-0.6	0.7	4.7	3.0	-1.1
Medication: Ramipril	1.7	2.1	4.5	1.1	1.6	1.8	-1.2	0.4	2.1
Mouth/teeth dental problems: Dentures	1.7	2.8	5.6	2.2	2.4	1.4	0.6	1.6	1.2
Number of self-reported non-cancer illnesses	1.7	2.9	12.9	-1.0	1.2	0.3	-3.6	-1.1	1.0
Ulcerative Colitis (UC)	1.6	3.1	5.4	1.9	1.5	2.3	0.7	1.7	2.0
Systolic Blood Pressure	1.6	7.8	14.1	1.5	3.8	3.4	-2.4	0.9	3.5
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	4.0	-1.3	-0.2	-2.0	-1.0	-1.3	-1.6
Father’s age at death	1.6	2.2	4.8	-1.3	-2.2	-2.0	-0.5	-0.7	-1.3
Medication: Blood pressure	1.6	3.1	6.1	2.0	1.8	0.6	0.5	2.5	2.2
Verbal and Numeric Reasoning (VNR)	1.5	3.7	9.5	-0.8	-3.0	-0.3	3.1	0.1	-1.7
Height	1.5	28.8	48.4	7.0	5.5	4.9	4.0	6.6	3.2
Sensitivity / hurt feelings	1.5	2.5	6.2	0.5	2.5	1.5	-1.9	-0.2	1.7
Exposure to tobacco smoke outside home	1.5	2.0	4.3	0.7	1.8	2.1	-0.7	-0.0	1.8
Illnesses of siblings: Diabetes	1.5	1.8	8.2	-0.8	0.8	0.4	-2.9	-0.9	0.7
Whole body fat-free mass	1.5	8.3	22.3	3.6	-0.7	-0.2	4.7	3.6	-0.9
Mood swings	1.5	2.7	6.6	0.8	2.2	2.6	0.9	0.4	1.7
Illnesses of father: None of the above (group 1)	1.5	1.9	3.4	1.9	1.4	1.2	0.9	1.8	0.7
Whole body water mass	1.5	8.3	22.0	3.6	-0.7	-0.2	4.7	3.6	-0.9
Pain experienced in last month	1.5	2.5	6.6	-0.2	-2.6	-0.3	2.1	-0.6	-1.8
Schizophrenia vs Biploar Disorder	1.4	1.9	5.1	1.4	2.3	0.9	-0.9	1.0	1.3
Alzheimer’s Disease (in mother)	1.4	1.6	5.5	0.3	-0.6	-1.3	2.4	0.5	-1.4
Alzheimer’s Disease (including proxy)	1.4	2.0	7.2	0.4	-1.1	-0.9	2.7	0.6	-1.5
Irritable Bowel Disease (IBD)	1.4	3.3	4.7	2.0	1.5	2.2	1.5	2.0	1.7
Type 2 Diabetes (T2D) (2018)	1.4	2.6	7.6	-0.3	1.4	-0.0	-2.8	-0.7	2.3
Time employed in main current job	1.4	1.6	7.3	-0.6	1.2	0.2	-2.7	-0.6	0.0
Medication: Cholesterol lowering	1.4	2.2	5.8	0.4	2.1	1.3	-1.1	-0.0	2.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	9.7	2.7	0.7	0.9	2.8	3.1	-0.1
Standing height	1.4	13.7	28.5	5.3	2.5	1.7	3.9	5.2	1.3
Tense / ‘highly strung’	1.4	2.3	6.9	-1.8	0.1	-0.2	-2.6	-1.9	-0.7
Peak expiratory flow (PEF)	1.4	3.1	6.9	2.5	0.8	0.7	1.8	2.6	1.1
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	5.1	0.1	-2.3	-1.8	1.4	0.9	-1.8
Ever had bowel cancer screening	1.4	1.6	6.6	0.2	-1.1	-1.1	2.6	0.3	-0.6
Diabetes diagnosed by doctor	1.4	2.2	9.1	-0.6	0.9	-1.0	-3.0	-0.6	1.4
Osteoarthritis (self-reported)	1.4	1.8	3.7	-1.9	-1.0	-0.1	-0.5	-1.5	-1.9
Average weekly champagne plus white wine intake	1.4	1.9	6.6	-1.1	-2.6	-0.5	0.5	-1.2	-1.3
Crohns Disease (2017)	1.3	2.8	4.0	1.9	1.0	1.2	2.0	2.0	1.6
Bipolar Disorder (2011)	1.3	1.3	2.6	0.7	1.6	1.0	-0.9	1.4	0.9
Ever used hormone-replacement therapy (HRT)	1.3	1.6	3.8	-0.8	-1.3	-1.9	0.5	-1.0	-1.5
Multivitamins +/- minerals	1.3	1.7	5.3	1.6	-0.7	0.1	2.3	1.3	0.4
Medication: Atenolol	1.3	1.6	3.5	0.2	1.9	0.8	-1.5	0.1	1.8
Number of live births	1.3	1.8	4.0	0.6	-1.4	-1.7	2.0	0.5	-1.2
Exposure to tobacco smoke at home	1.3	1.5	4.3	-1.2	-0.1	-0.5	-2.1	-1.7	0.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.5	1.8	-0.6	0.9	1.8	2.1	0.7
Arm fat-free mass (right)	1.3	6.7	14.6	3.5	-0.2	-0.2	3.8	3.6	-1.0
Pulse rate, automated reading	1.3	4.3	6.5	1.7	2.4	0.3	-2.5	2.2	2.4
Tinnitus: Yes, now most or all of the time	1.3	1.5	5.4	1.1	-0.1	1.0	2.3	0.5	1.1
Medication: Atorvastatin	1.3	1.6	2.8	0.6	1.4	1.4	-1.7	0.5	1.5
Arm fat-free mass (left)	1.3	6.7	14.4	3.5	0.1	0.2	3.8	3.6	-0.4
Prostate Cancer	1.2	1.7	7.2	-0.9	1.1	-0.3	-2.7	-0.6	0.7
Age at First Birth	1.2	1.7	5.8	-0.6	-2.4	-1.4	0.6	-1.1	-0.9
BMI	1.2	7.1	13.8	-2.6	-3.7	-2.4	0.1	-2.7	-3.0
Pack years adult smoking proportion	1.2	1.8	7.2	-0.4	0.7	-0.8	-2.7	-1.3	0.6
Fed-up feelings	1.2	2.2	4.3	0.8	2.0	2.1	-0.6	0.9	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.7	3.1	0.2	1.0	1.8	-1.6	0.4	1.8
Leg predicted mass (left)	1.2	6.2	22.2	2.4	-1.5	-0.3	4.7	2.3	-1.2
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	3.8	0.0	1.8	1.1	-1.7	-0.1	1.9
Qualifications: A levels/AS levels or equivalent	1.2	2.7	7.0	-1.9	-2.7	-0.8	0.1	-0.7	-2.1
Lung cancer (father)	1.2	1.4	4.2	-0.1	0.8	-1.7	-0.8	0.2	-2.1
Had major operations	1.2	1.4	3.1	-1.4	-1.8	-1.1	-0.2	-1.3	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	3.5	1.6	1.4	1.8	1.9	1.7	0.8
Medication: Bendroflumethiazide	1.2	1.8	6.0	-0.4	1.7	0.5	-2.4	-0.5	1.3
Irritability	1.2	2.0	4.3	-1.7	-1.1	-0.6	-1.2	-2.1	-1.5
Heart disease (siblings)	1.2	1.5	3.0	0.9	1.7	1.7	-0.3	1.1	0.9
Impedance of whole body	1.2	6.0	13.1	-1.4	2.4	2.1	-3.6	-1.8	2.8
Body Mass Index (BMI) (2010)	1.1	1.5	6.6	0.4	-1.1	0.1	2.6	0.3	-1.0
Fasting Glucose	1.1	1.3	2.6	-0.9	-1.1	-1.6	-0.4	-0.9	-1.6
Leg fat-free mass (left)	1.1	6.0	21.3	2.4	-1.6	-0.4	4.6	2.2	-1.3
Medication: Levothyroxine sodium	1.1	1.8	4.0	0.6	1.1	1.8	-1.1	0.8	2.0
Forced vital capacity (FVC), Best measure	1.1	4.2	11.0	2.3	-0.1	0.5	3.3	2.7	-1.1
Medication: Blood pressure	1.1	2.0	3.1	-0.8	1.6	1.4	-1.7	-1.8	0.7
Arm predicted mass (right)	1.1	5.9	12.0	3.3	-0.1	-0.2	3.5	3.3	-1.1
Family relationship satisfaction	1.1	1.4	4.1	1.5	0.3	0.9	0.9	2.0	0.4
Leg fat-free mass (right)	1.1	5.9	19.8	2.3	-1.6	-0.5	4.5	2.2	-1.6
Eye problems/disorders: Cataract	1.1	1.3	2.5	-1.3	-0.7	-1.0	-1.6	-1.4	-0.1
Medication for cholesterol	1.1	1.7	3.5	-1.5	-1.1	0.1	0.2	-1.9	-1.9
Back pain experienced in last month	1.1	1.6	3.9	1.2	1.6	0.5	-0.0	1.2	2.0
Leg predicted mass (right)	1.1	6.0	20.2	2.4	-1.6	-0.5	4.5	2.2	-1.6
Basal metabolic rate	1.1	6.1	17.4	3.0	-0.9	-0.3	4.2	3.0	-1.0
Pack years of smoking	1.1	1.6	6.7	-0.3	0.7	-0.8	-2.6	-1.2	0.5
Arm predicted mass (left)	1.1	5.7	12.0	3.3	0.1	-0.0	3.5	3.3	-0.4
Depressed Affect (Nagel 2018)	1.0	2.1	6.1	0.5	1.2	2.5	0.5	0.8	2.0
Neuroticism (Nagel 2018)	1.0	2.3	7.5	0.4	1.7	2.7	-0.4	0.2	1.8
Diabetes (mother)	1.0	1.3	5.0	-0.8	1.4	-0.0	-2.2	-0.2	0.4
Serious illness, injury or assault to yourself	1.0	1.2	2.2	-1.2	-1.0	-1.2	-1.5	-0.8	-0.3
Medication: Paracetamol	1.0	1.6	3.7	0.8	1.9	1.6	-0.2	1.4	0.8
Friendships satisfaction	1.0	1.2	2.3	1.2	0.4	1.5	0.7	1.1	1.3
Commuting to job workplace: Walk	1.0	1.0	2.9	-1.0	-0.5	-1.7	-0.4	-1.0	-1.0
Bipolar Disorder (2018)	0.9	1.3	3.4	-1.5	-0.6	-0.7	-1.8	-0.9	-0.9
Blood Eosinophil Count	0.9	6.7	15.7	1.0	2.6	2.5	-4.0	-0.4	3.2
Neuroticism	0.9	2.1	5.9	1.0	1.5	2.4	0.1	0.6	1.7
Angina	0.9	1.1	3.2	1.0	1.8	1.0	-0.7	0.8	0.7
Medication: Co-codamol	0.9	1.0	2.3	-1.2	0.9	0.9	-1.5	-0.8	0.2
Taking other prescription medications	0.9	1.3	4.4	-1.3	0.4	-0.0	-2.1	-1.3	0.2
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.6	0.2	0.6	1.1	-1.3	0.8	1.6
Chronic bronchitis/emphysema (father)	0.9	1.1	2.9	-0.8	-1.7	-0.8	0.2	-0.9	-1.1
Nervous feelings	0.9	1.7	4.1	0.1	2.0	1.1	-1.7	-0.4	1.4
Neuroticism score	0.9	1.9	4.5	0.7	1.9	2.1	-0.5	0.2	1.6
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	3.2	0.1	1.5	1.8	-0.9	0.0	1.7
Noisy workplace	0.9	1.1	3.3	-0.7	-0.0	-0.9	-1.8	-1.4	-0.3
Pulse wave Arterial Stiffness index	0.9	1.1	2.5	1.6	0.8	1.1	0.7	0.9	0.9
Length of working week for main job	0.9	0.9	2.9	-0.8	1.0	-0.2	-1.7	-1.1	0.2
Birth weight	0.9	1.9	3.6	-0.7	-1.6	-1.7	1.3	-0.3	-1.9
Number of children fathered	0.9	1.0	3.1	0.8	1.8	0.8	-0.3	0.5	1.2
Neck or shoulder pain in last month	0.9	1.2	4.3	-1.2	0.0	-0.9	-2.1	-0.5	-0.6
Angina (self-reported)	0.9	1.1	3.3	0.9	1.8	1.0	-0.7	0.8	0.8
Arm fat percentage (left)	0.9	3.5	8.3	-2.5	-2.3	-0.7	-0.4	-2.9	-0.9
Breast cancer (self-reported)	0.9	1.1	3.7	0.1	-1.2	-0.6	0.7	0.7	-1.9
Medication: Gliclazide	0.9	1.1	4.3	-0.3	0.3	0.8	-1.0	-0.4	2.1
Unable to work because of sickness or disability	0.9	1.2	2.3	-0.1	1.4	1.3	-1.5	-0.5	0.8
Vascular/heart problems diagnosed by doctor	0.9	2.4	6.4	-0.8	-2.5	-1.4	1.3	-0.7	-1.7
Respiratory disease	0.8	1.7	6.2	-1.1	-0.3	-0.7	-2.5	-1.2	-0.8
Lung FVC	0.8	3.9	9.1	-0.9	-2.5	-0.6	2.5	-0.3	-3.0
Systolic blood pressure, automated reading	0.8	2.2	5.9	-0.0	1.7	1.5	-2.4	-0.3	1.4
Vitamin and mineral supplements	0.8	1.1	3.5	-0.5	1.2	0.5	-1.9	-0.5	0.9
Qualifications: None of the above	0.8	1.7	4.4	-0.5	2.1	0.5	-2.1	-0.8	0.8
Arm fat percentage (right)	0.8	3.1	7.3	-2.4	-2.2	-0.7	-0.3	-2.7	-0.6
Hair/balding pattern: Pattern 3	0.8	1.2	2.6	-0.7	-1.6	-1.4	0.1	-0.2	-1.4
Body fat percentage	0.8	3.1	8.6	-2.5	-0.9	-0.0	-1.6	-2.9	-0.2
Medication: Ibuprofen	0.8	1.0	2.8	1.7	0.5	0.2	0.9	1.4	0.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.8	0.6	1.7	1.3	-0.5	0.2	0.5
Illnesses of father: Heart disease	0.8	1.1	2.0	-1.4	-0.8	-1.1	-1.1	-1.1	-0.3
Qualifications: nursing, teaching	0.8	1.3	4.8	-0.6	-2.2	-0.8	1.3	-0.3	-0.0
High cholesterol (Self-reported)	0.8	1.4	3.0	1.1	1.6	0.5	-0.6	1.1	1.7
Medication: Paracetamol	0.8	1.2	3.6	0.9	1.9	1.0	0.1	1.4	0.2
Medication: Lisinopril	0.8	1.0	3.1	-1.1	-1.7	-0.3	0.2	-1.0	-0.9
Breast Cancer	0.7	1.7	4.4	-0.1	-2.1	-1.3	1.7	0.2	-1.0
Cardiovascular Disease	0.7	2.3	6.5	0.7	2.1	0.8	-1.3	0.3	2.5
Number of treatments/medications taken	0.7	1.2	4.9	-0.5	1.2	0.5	-2.2	-0.5	0.4
Medication: Metformin	0.7	1.0	4.1	0.1	0.4	-0.3	-1.3	-0.0	2.0
Falls in the last year	0.7	1.0	2.6	-0.3	-1.6	-0.5	1.6	-0.6	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.1	1.4	0.3	0.2	0.7	1.4	0.8
Leg fat percentage (right)	0.7	2.6	5.7	-2.1	-0.2	-0.2	-2.3	-2.4	0.2
Comparative body size at age 10	0.7	2.0	5.4	0.1	-2.3	-0.3	2.3	0.7	-0.9
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.3	-1.0	1.2	-0.8	-1.0	-0.9	-0.7
Knee pain experienced in last month	0.7	1.1	2.0	-0.5	1.4	-1.0	-1.4	-1.0	-0.6
Hypertension (Self-reported)	0.7	2.0	5.4	0.6	2.3	1.1	-0.9	0.1	2.0
Leg fat percentage (left)	0.7	2.6	6.0	-2.1	0.0	0.2	-2.5	-2.3	0.0
Alcohol drinker status: Previous	0.7	0.7	2.1	0.5	-1.4	-0.2	1.4	-0.0	0.5
Alzheimer’s Disease (in father)	0.6	0.7	2.9	0.6	-0.5	0.3	1.7	0.5	-0.4
Rheumatoid Arthritis	0.6	0.8	2.7	0.7	0.2	1.6	-0.6	0.6	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	0.4	0.2	-1.0	-1.3	1.0	0.2
Chronotype (morning person)	0.6	1.4	4.8	-0.3	-1.2	-2.2	0.3	-0.7	1.1
Relative age of first facial hair	0.6	1.1	2.7	1.1	-1.0	-1.6	0.9	1.1	-0.3
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	0.6	0.9	-0.7	-0.0	0.9	1.3
Trunk fat percentage	0.6	2.4	7.3	-2.2	-0.7	0.2	-1.3	-2.7	-0.2
Townsend deprivation index at recruitment	0.6	0.9	1.9	-0.3	-1.4	-1.1	0.8	-0.9	-0.9
High blood pressure	0.6	1.8	4.3	0.8	2.1	1.2	-0.8	0.5	1.9
Stomach or abdominal pain in last month	0.6	0.7	1.9	-0.2	1.2	0.4	-1.4	-0.5	0.7
Sitting height	0.6	4.3	10.2	2.7	3.2	1.1	1.0	2.3	0.8
Mouth/teeth dental problems	0.6	0.9	1.7	-1.3	-0.8	-0.8	-0.9	-1.1	-0.7
Pain all over the body in last month	0.6	0.6	1.6	-1.0	0.3	-0.3	-1.3	-0.9	0.2
Impedance of arm (right)	0.6	2.9	4.2	-1.5	1.1	1.5	-2.0	-2.0	2.0
Worrier / anxious feelings	0.6	1.0	3.1	0.8	0.7	1.8	-0.2	0.3	1.3
Pulse wave peak to peak time	0.6	0.7	1.5	-1.2	-0.6	-0.9	-0.5	-0.6	-0.9
Supplements: Vitamin C	0.6	0.7	1.9	-0.2	1.4	0.8	-1.1	0.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.8	1.5	-0.7	-0.4	0.9	-0.6	-1.2	1.2
Smoking status: Previous	0.6	0.9	3.5	0.1	-1.1	0.3	1.9	0.3	-0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	4.2	2.1	0.5	-0.2	0.7	1.5	0.6
Asthma (self-reported)	0.6	1.3	5.4	-0.9	-0.3	-0.5	-2.3	-0.9	-0.6
Medication: Aspirin	0.6	0.8	3.8	-0.7	0.4	-0.2	-1.9	-0.7	-0.0
Illnesses of father: High blood pressure	0.6	0.7	1.2	-1.0	-1.1	-1.0	0.0	-0.8	-0.3
Number of operations (self-reported)	0.6	0.8	2.5	-0.3	-1.6	-1.2	0.8	-0.2	-0.6
Fractured/broken bones in last 5 years	0.6	0.8	1.8	0.5	-0.3	1.1	1.1	0.3	1.3
Age started oral contraceptive pill	0.6	0.7	2.7	-0.2	1.3	-0.1	-1.6	0.0	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.0	-0.7	-1.2	-0.8	0.2	-0.5	-1.4
Depression (Nagel 2018)	0.5	0.7	2.3	0.1	0.6	1.5	-0.4	0.6	0.9
Worry (Nagel 2018)	0.5	1.1	3.2	0.5	1.3	1.8	-0.9	0.0	1.0
Mean Putamen Volume	0.5	0.5	2.2	0.6	0.1	1.5	0.5	0.5	0.3
Relative age voice broke	0.5	0.7	1.0	0.5	-1.0	-1.0	1.0	0.8	-0.7
Qualifications: CSEs or equivalent	0.5	0.6	1.3	0.7	0.9	0.3	-0.3	1.0	1.1
Body mass index (BMI)	0.5	2.1	4.9	-1.3	-2.2	-1.2	0.7	-1.4	-1.6
Past tobacco smoking	0.5	0.9	2.4	0.2	1.5	-0.2	-1.5	0.2	0.8
Had other major operations	0.5	0.6	1.6	-0.3	-1.3	-0.6	0.4	-0.4	-1.0
Impedance of arm (left)	0.5	2.3	4.4	-1.6	0.5	1.3	-1.7	-2.1	1.3
Number of full brothers	0.5	0.6	1.6	-1.0	0.1	-0.8	-0.3	-1.3	-0.6
Age at first live birth	0.5	0.9	2.7	-0.8	1.1	0.5	-1.7	-0.8	0.4
Qualifications: College or University degree	0.5	1.7	4.9	-0.7	-2.2	0.8	1.7	-0.5	-0.9
Migraine (self-reported)	0.5	0.6	1.3	-0.1	1.1	1.1	-0.9	-0.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	2.1	-0.5	0.8	-0.1	-1.4	-0.5	0.8
Age at last live birth	0.5	0.7	2.2	0.6	1.5	0.9	-0.5	0.2	0.7
Long-standing illness, disability or infirmity	0.5	0.7	1.4	0.5	0.7	1.1	-1.2	0.1	1.0
Commuting to job workplace: Public transport	0.5	0.6	2.1	0.8	0.2	0.7	1.4	0.7	-0.3
Average weekly beer plus cider intake	0.5	0.7	2.1	1.1	0.2	-0.1	1.4	0.7	-0.7
Commuting to job workplace: Cycle	0.5	0.6	2.0	0.2	-1.4	-1.2	-0.3	0.1	0.1
Lupus	0.4	0.6	2.0	-0.8	0.5	0.2	-1.4	-0.6	-0.5
Primary Biliary Cirrhosis	0.4	0.5	1.2	-0.9	-0.7	-0.1	-1.1	-0.7	-0.5
Blood Red Count	0.4	4.2	9.2	1.0	3.0	-0.8	-3.0	0.7	2.2
Heel T-Score	0.4	3.1	8.6	-0.1	-2.0	-0.1	2.9	-1.0	-2.2
Hypothyroidism (self reported)	0.4	0.9	3.1	0.1	-0.4	0.8	-1.8	0.3	1.2
Hair Pigment	0.4	11.4	23.4	-2.8	-4.8	-4.3	-0.7	-2.1	-3.7
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.5	-0.1	0.7	1.2	-0.9	0.2	1.0
Severe depression (siblings)	0.4	0.5	1.5	0.1	-1.2	-0.0	0.7	0.7	-0.6
Hand grip strength (right)	0.4	1.1	2.9	1.1	0.6	0.4	1.2	1.7	0.3
Maternal smoking around birth	0.4	0.6	2.3	-0.4	-0.9	-0.4	1.5	-0.5	-0.2
Hearing difficulty/problems with background noise	0.4	0.6	1.5	-0.2	1.1	0.7	-1.2	0.0	0.7
Happiness	0.4	0.5	1.1	0.6	0.9	0.4	-1.0	0.6	0.2
Asthma	0.4	0.8	4.2	-0.5	0.0	-0.1	-2.0	-0.5	0.1
Depression (self-reported)	0.4	0.5	1.5	-0.6	-0.5	-0.6	0.2	-0.8	-1.2
Prospective memory result	0.4	0.5	1.4	-0.8	0.4	-0.4	-0.6	-0.6	-1.2
Blood clot in the leg (DVT)	0.4	0.5	1.4	-0.4	-0.9	-0.5	0.3	-0.3	-1.2
Wheeze or whistling in the chest in last year	0.4	0.8	2.1	-0.5	-0.1	-1.0	-1.4	-0.9	-0.8
Medication: Seretide 50 evohaler	0.4	0.4	0.6	-0.5	-0.8	-0.6	-0.8	-0.3	-0.8
Chest pain or discomfort	0.4	0.6	2.6	-0.3	-0.8	-1.6	-0.3	-0.2	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.2	0.2	-0.3	0.4	0.7	0.7	-1.1
Arm fat mass (left)	0.4	1.5	3.8	-1.0	-2.0	-0.7	0.9	-1.3	-1.1
Wears glasses or contact lenses	0.4	0.4	1.0	-1.0	0.1	-1.0	-0.5	-0.4	-0.6
Myopia	0.4	0.6	1.5	0.2	0.6	-0.9	-1.2	0.4	0.7
Basal cell carcinoma (self-reported)	0.4	0.5	1.4	-0.1	-1.2	-0.0	0.8	0.1	-0.9
Neuroticism (2016)	0.3	0.4	1.9	0.3	-0.1	1.4	0.7	-0.2	0.5
Hand grip strength (left)	0.3	0.8	2.6	1.0	0.7	0.3	0.7	1.6	0.2
Other serious medical condition/disability diagnosed by doctor	0.3	0.5	1.9	-0.3	-1.4	-0.6	-0.6	0.1	0.1
Average weekly fortified wine intake	0.3	0.4	1.2	0.3	-1.1	0.5	0.7	0.2	-0.2
Financial difficulties in last 2 years	0.3	0.4	0.9	-0.1	-0.9	-0.9	0.7	-0.2	-0.4
Medication: Simvastatin	0.3	0.5	2.0	0.5	0.0	-0.3	0.8	0.3	1.4
Weight	0.3	1.7	6.1	1.1	-1.0	-0.3	2.5	0.9	-0.9
Alcohol intake versus 10 years previously	0.3	0.5	0.8	0.5	-0.0	-0.9	-0.5	0.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.9	0.0	0.7	0.1	-0.8	-0.3	1.0
Medication: Lansoprazole	0.3	0.3	0.8	0.3	-0.1	0.9	-0.4	0.0	0.9
Arm fat mass (right)	0.3	1.3	3.5	-1.0	-1.9	-0.7	0.8	-1.2	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.7	-0.5	0.1	0.2	0.8	-0.5	1.3
Hair/balding pattern: Pattern 4	0.3	0.8	1.5	-1.2	-0.9	-0.1	-0.3	-1.2	-1.1
Loud music exposure frequency	0.3	0.4	1.5	0.2	-0.4	-0.1	0.6	-0.2	-1.2
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.3	0.4	-0.1	0.9	-0.9	0.7	1.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.6	-0.4	0.5	-0.1	-1.3	-0.5	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.9	-0.6	-1.0	0.0	-0.3	-0.7	0.4
Leg fat mass (right)	0.3	1.1	2.4	-1.4	-1.2	-0.6	-0.3	-1.5	-0.7
Alcohol intake frequency.	0.3	0.7	1.6	0.6	0.9	-0.4	-0.8	0.9	1.3
Number of full sisters	0.3	0.3	1.5	-0.1	-0.2	-1.2	-0.7	0.0	0.2
Medication: Aspirin	0.3	0.4	1.8	-0.4	0.2	-0.2	-1.4	-0.3	0.3
Average weekly red wine intake	0.3	0.5	1.3	-0.9	0.1	0.5	-1.2	-0.6	-0.6
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.3	0.1	-0.4	-0.1	1.5	0.8	-0.2
Financial situation satisfaction	0.3	0.3	0.7	0.3	-0.9	-0.1	0.7	0.3	-0.7
Ever smoked	0.3	0.5	1.3	-0.4	-1.2	0.4	0.6	-0.2	-1.0
Ever depressed for a whole week	0.3	0.3	1.2	-0.4	0.5	-0.3	-0.1	-0.6	1.1
Ulcerative Colitis	0.2	0.3	0.7	-0.4	-0.9	0.6	-0.4	-0.7	-0.1
Blood Platelet Count	0.2	2.2	7.8	-1.0	-1.3	-0.8	-2.8	-1.2	-0.5
Smoking Status	0.2	0.6	1.4	0.8	-0.9	0.6	1.2	0.7	0.1
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.1	-0.8	-0.6	0.3	-0.2	0.1
Supplements: Glucosamine	0.2	0.3	1.3	-0.3	-0.2	-0.1	1.1	0.0	-0.4
Had menopause	0.2	0.2	0.9	-0.3	-0.2	-0.7	0.2	-0.1	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.6	-0.0	0.8	0.4	0.2	0.2	0.6
Illnesses of mother	0.2	0.3	0.6	-0.5	-0.5	0.8	0.3	-0.7	-0.3
High blood pressure (siblings)	0.2	0.2	0.4	-0.6	-0.1	0.1	-0.6	-0.6	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.7	0.4	-0.3	0.1	0.8	0.8	0.1
Shortness of breath walking on level ground	0.2	0.2	0.7	-0.3	-0.1	0.3	-0.2	-0.5	0.9
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.9	0.6	0.2	0.3	-0.2	0.3	0.9
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	-0.4	-0.9	-0.6	0.6	-0.6	-0.4
Heart disease (mother)	0.2	0.3	0.8	-0.1	0.7	-0.3	-0.9	-0.2	-0.4
Whole body fat mass	0.2	0.8	2.0	-1.1	-1.0	-0.4	0.0	-1.4	-0.7
Comparative height size at age 10	0.2	1.0	1.9	1.4	1.4	0.1	0.7	1.0	-1.0
Loneliness, isolation	0.2	0.3	1.0	-0.3	-0.2	0.7	-1.0	-0.2	0.5
Smoking status: Current	0.2	0.2	0.6	0.0	-0.2	-0.8	-0.8	-0.2	-0.4
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	0.4	0.4	0.6	0.3	0.7	0.4
Risk taking	0.2	0.3	0.9	0.2	-0.6	-0.9	0.6	0.1	0.0
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.7	0.1	-0.0	0.6	0.5	0.5	-0.8
Diastolic blood pressure, automated reading	0.2	0.7	2.0	-0.1	0.0	0.1	-1.3	-0.6	1.4
Leg fat mass (left)	0.2	0.8	1.9	-1.2	-1.0	-0.3	-0.3	-1.4	-0.7
LDL Cholesterol	0.1	0.2	0.3	-0.3	0.2	-0.1	-0.6	-0.6	0.5
Tanning	0.1	1.8	3.0	1.5	1.2	1.3	1.7	1.1	1.2
Hearing difficulty/problems: Yes	0.1	0.1	0.4	-0.4	-0.2	-0.2	-0.6	0.2	-0.4
Current tobacco smoking	0.1	0.2	0.5	0.3	0.2	-0.7	-0.7	0.2	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.1	0.4	-0.0	0.3	-0.1	0.7	-0.2	-0.4
High blood pressure (mother)	0.1	0.2	0.5	0.2	-0.7	-0.7	-0.2	0.4	-0.1
Trunk fat mass	0.1	0.6	1.9	-1.0	-0.8	-0.0	0.1	-1.4	-0.4
Waist circumference	0.1	0.4	0.6	0.6	-0.4	-0.8	0.7	0.6	0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	1.4	-0.1	0.2	0.1	1.2	-0.3	-0.3
Illnesses of siblings	0.1	0.2	0.6	0.1	0.2	-0.8	0.5	0.2	-0.5
Breastfed as a baby	0.1	0.2	0.4	0.1	0.1	-0.6	-0.3	0.2	-0.6
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.2	-0.4	0.1	0.4	-0.4	-0.2	0.0
Medication: Amlodipine	0.1	0.1	0.5	0.1	0.3	0.4	-0.3	-0.1	0.7
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	0.1	-0.1	0.1	0.5	-0.6	0.4
Worry too long after embarrassment	0.1	0.2	0.7	-0.2	0.8	0.5	-0.5	-0.3	0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.6	0.1	0.2	0.4	0.8	0.1	-0.4
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.2	-0.5	0.2	-0.3	-0.2	0.5
Mineral and other dietary supplements	0.1	0.2	0.5	-0.0	0.4	0.5	-0.7	0.0	0.5
Guilty feelings	0.1	0.1	0.3	-0.4	0.2	0.4	0.2	-0.5	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.0	-0.2	-0.4	-0.1	0.3	-0.3
Hearing aid user	0.1	0.1	0.3	0.1	-0.4	0.6	-0.1	0.5	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.3	-0.2	-0.5	-0.0	0.3	0.3	-0.1
Number of incorrect matches in round	0.0	0.1	0.2	-0.1	-0.1	-0.1	0.4	-0.4	0.2
Leg pain on walking	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	-0.2	0.3

Hub : Genes

PEMT

Models

Trait associations