Best TWAS P=2.21e-31 · Best GWAS P=7.75e-28 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Female) | AC074117.10 | 0.06 | 0.01 | lasso | 2 | 0.04 | 2.7e-02 | -7.80 | -8.6 | 6.7e-18 | -0.23 | 0.04 | 0.05 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | RP11-373D23.3 | 0.17 | 0.01 | enet | 15 | 0.04 | 1.2e-02 | -2.10 | 5.5 | 5.0e-08 | 0.28 | 0.09 | 0.08 | TRUE |
| 3 | GTEx | Esophagus Muscularis | NRBP1 | 0.07 | 0.04 | lasso | 6 | 0.04 | 1.3e-03 | -3.14 | 5.5 | 4.4e-08 | 0.82 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Lung | RP11-373D23.3 | 0.08 | 0.00 | enet | 21 | 0.02 | 2.3e-02 | -6.06 | 5.8 | 8.6e-09 | 0.23 | 0.20 | 0.11 | FALSE |
| 5 | GTEx | Stomach | AC074117.10 | 0.06 | 0.01 | lasso | 7 | 0.01 | 7.8e-02 | -3.14 | -9.9 | 3.1e-23 | -0.36 | 0.20 | 0.08 | FALSE |
| 6 | GTEx | Testis | NRBP1 | 0.16 | 0.09 | lasso | 3 | 0.06 | 1.8e-03 | -3.14 | 5.7 | 1.2e-08 | 0.80 | 0.03 | 0.96 | FALSE |
| 7 | GTEx | Testis | AC074117.10 | 0.14 | 0.08 | lasso | 6 | 0.12 | 4.5e-06 | -1.89 | 6.5 | 7.0e-11 | 0.85 | 0.05 | 0.95 | FALSE |
| 8 | GTEx | Thyroid | FNDC4 | 0.24 | 0.10 | enet | 23 | 0.16 | 2.2e-12 | -9.03 | -11.0 | 3.4e-28 | -0.69 | 0.67 | 0.33 | FALSE |
| 9 | METSIM | Adipose | BRE | 0.03 | 0.00 | blup | 534 | 0.00 | 1.3e-01 | -0.47 | 6.5 | 1.0e-10 | 0.30 | 0.10 | 0.05 | TRUE |
| 10 | YFS | Blood | EIF2B4 | 0.01 | 0.00 | enet | 9 | 0.00 | 8.5e-02 | -0.60 | -5.2 | 2.0e-07 | -0.52 | 0.04 | 0.03 | FALSE |
| 11 | YFS | Blood | MRPL33 | 0.02 | 0.01 | blup | 385 | 0.01 | 6.4e-05 | -7.33 | 7.3 | 4.0e-13 | 0.22 | 0.97 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GPN1 | 0.06 | 0.02 | lasso | 6 | 0.02 | 7.2e-05 | 9.10 | 7.4 | 1.6e-13 | 0.54 | 0.00 | 0.98 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SNX17 | 0.08 | 0.01 | blup | 25 | 0.02 | 6.6e-05 | -3.35 | -5.2 | 1.7e-07 | -0.55 | 0.02 | 0.34 | FALSE |
| 14 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SUPT7L | 0.06 | 0.03 | blup | 29 | 0.05 | 2.0e-03 | -8.54 | -6.6 | 3.6e-11 | -0.04 | 0.02 | 0.63 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SUPT7L | 0.05 | 0.02 | blup | 28 | 0.04 | 5.2e-05 | -8.66 | -10.4 | 1.9e-25 | -0.40 | 0.01 | 0.94 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | FNDC4 | 0.13 | 0.06 | lasso | 2 | 0.05 | 1.1e-03 | 10.94 | -11.7 | 2.2e-31 | -0.99 | 0.00 | 0.95 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | FNDC4 | 0.24 | 0.09 | enet | 9 | 0.17 | 1.9e-16 | -9.16 | -10.7 | 1.1e-26 | -0.70 | 0.41 | 0.59 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | GCKR | 0.18 | 0.08 | enet | 5 | 0.13 | 1.7e-12 | -9.03 | -10.6 | 4.1e-26 | -0.64 | 0.90 | 0.10 | FALSE |
| 19 | The Cancer Genome Atlas | Thyroid Carcinoma | IFT172 | 0.08 | 0.01 | blup | 43 | 0.02 | 6.1e-03 | -9.27 | -10.8 | 4.8e-27 | -0.54 | 0.02 | 0.27 | FALSE |