[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr11:46,180,005-48,559,571

Best TWAS P=1.31e-25 · Best GWAS P=2.51e-25 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	GTEx	Cells Transformed fibroblasts	NDUFS3	0.08	0.01	lasso	2	0.01	3.3e-02	10.399	-10.5	1.3e-25	-0.98	0.00	0.98	TRUE
65	The Cancer Genome Atlas	Esophageal Carcinoma	C1QTNF4	0.39	0.33	blup	15	0.35	6.1e-12	10.282	-10.3	8.2e-25	-0.98	0.00	1.00	FALSE
5	GTEx	Artery Aorta	C1QTNF4	0.09	0.10	lasso	1	0.08	3.2e-05	10.282	-10.3	8.5e-25	-1.00	0.00	0.99	FALSE
18	GTEx	Esophagus Mucosa	C1QTNF4	0.10	0.11	lasso	1	0.10	5.0e-07	10.282	-10.3	8.5e-25	-1.00	0.00	1.00	FALSE
23	GTEx	Heart Left Ventricle	C1QTNF4	0.10	0.11	lasso	1	0.09	1.1e-05	10.282	-10.3	8.5e-25	-1.00	0.00	0.99	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	C1QTNF4	0.12	0.12	lasso	1	0.12	1.6e-07	10.282	-10.3	8.5e-25	-1.00	0.00	1.00	FALSE
20	GTEx	Esophagus Muscularis	C1QTNF4	0.10	0.05	enet	23	0.06	1.4e-04	10.399	-10.3	1.0e-24	-0.93	0.01	0.99	FALSE
28	GTEx	Muscle Skeletal	C1QTNF4	0.09	0.14	lasso	3	0.13	9.9e-13	10.282	-10.2	1.3e-24	-0.98	0.00	1.00	FALSE
79	The Cancer Genome Atlas	Lung Adenocarcinoma	C1QTNF4	0.03	0.02	blup	15	0.02	1.3e-03	10.282	-10.2	2.9e-24	-0.97	0.00	0.97	FALSE
17	GTEx	Colon Transverse	C1QTNF4	0.07	0.02	lasso	6	0.03	2.0e-02	10.399	-10.1	5.8e-24	-0.96	0.01	0.96	FALSE
21	GTEx	Heart Atrial Appendage	C1QTNF4	0.26	0.14	lasso	9	0.17	3.9e-08	10.282	-10.1	8.8e-24	-0.95	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	C1QTNF4	0.16	0.22	lasso	4	0.22	2.5e-18	10.399	-10.0	1.2e-23	-0.98	0.00	1.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	C1QTNF4	0.25	0.22	lasso	12	0.23	4.2e-19	10.282	-10.0	1.8e-23	-0.95	0.00	1.00	FALSE
36	GTEx	Spleen	C1QTNF4	0.31	0.28	enet	29	0.34	1.8e-09	9.080	-9.9	5.0e-23	-0.89	0.07	0.92	FALSE
69	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C1QTNF4	0.12	0.14	enet	4	0.16	6.5e-18	9.049	-9.8	8.8e-23	-0.95	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM180B	0.07	0.08	lasso	3	0.08	9.1e-10	10.282	9.8	9.4e-23	0.95	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C1QTNF4	0.06	0.07	lasso	2	0.06	4.9e-06	9.130	-9.7	2.9e-22	-0.93	0.01	0.99	FALSE
30	GTEx	Nerve Tibial	C1QTNF4	0.20	0.23	enet	12	0.23	1.7e-16	10.282	-9.6	6.5e-22	-0.96	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	NUP160	0.05	0.05	blup	44	0.05	7.7e-04	-8.749	9.6	7.8e-22	0.82	0.06	0.47	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	C1QTNF4	0.06	0.04	lasso	4	0.03	4.3e-03	9.092	-9.6	1.1e-21	-0.92	0.00	0.92	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	MTCH2	0.35	0.40	enet	9	0.40	4.7e-56	9.049	9.4	3.8e-21	0.91	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	FNBP4	0.11	0.05	lasso	8	0.08	1.6e-06	-8.702	9.4	8.3e-21	0.88	0.04	0.96	FALSE
62	The Cancer Genome Atlas	Colon Adenocarcinoma	KBTBD4	0.14	0.01	blup	13	0.02	1.6e-02	-8.710	9.3	1.4e-20	0.90	0.00	0.53	FALSE
26	GTEx	Lung	C1QTNF4	0.18	0.15	lasso	6	0.13	3.2e-10	8.297	-9.3	1.6e-20	-0.91	0.08	0.92	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	C1QTNF4	0.32	0.18	enet	33	0.20	5.2e-11	10.282	-9.3	2.0e-20	-0.90	0.00	1.00	FALSE
45	NTR	Blood	MTCH2	0.02	0.04	lasso	1	0.04	1.3e-11	9.209	-9.2	3.3e-20	-0.88	0.90	0.10	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C1QTNF4	0.13	0.16	lasso	1	0.16	3.1e-09	9.190	-9.2	3.9e-20	-0.88	0.14	0.85	FALSE
39	GTEx	Whole Blood	C1QTNF4	0.09	0.05	lasso	3	0.03	1.4e-03	9.091	-9.1	6.2e-20	-0.86	0.18	0.73	FALSE
54	YFS	Blood	PSMC3	0.02	0.01	blup	289	0.01	2.8e-05	10.399	9.1	8.1e-20	0.84	0.00	0.99	FALSE
66	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1QTNF4	0.06	0.08	lasso	3	0.08	7.5e-09	9.049	-9.1	9.1e-20	-0.88	0.04	0.96	FALSE
74	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTCH2	0.11	0.11	lasso	2	0.10	6.4e-12	9.049	9.1	1.2e-19	0.87	0.09	0.91	FALSE
77	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C1QTNF4	0.19	0.19	lasso	3	0.19	3.2e-09	9.049	-9.1	1.2e-19	-0.87	0.09	0.91	FALSE
76	The Cancer Genome Atlas	Brain Lower Grade Glioma	PSMC3	0.10	0.05	blup	39	0.08	3.7e-09	8.336	9.1	1.4e-19	0.79	0.02	0.98	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	C1QTNF4	0.05	0.06	blup	281	0.06	1.7e-08	8.334	-9.0	1.8e-19	-0.86	0.09	0.91	FALSE
41	METSIM	Adipose	C1QTNF4	0.24	0.31	lasso	7	0.31	1.2e-46	9.049	-8.9	6.1e-19	-0.86	1.00	0.00	FALSE
27	GTEx	Muscle Skeletal	MTCH2	0.05	0.03	enet	15	0.04	1.5e-04	8.127	8.9	7.4e-19	0.84	0.05	0.94	FALSE
9	GTEx	Brain Cortex	C1QTNF4	0.26	0.04	lasso	8	0.02	1.2e-01	-8.535	-8.8	1.2e-18	-0.80	0.02	0.58	FALSE
85	The Cancer Genome Atlas	Thyroid Carcinoma	C1QTNF4	0.04	0.01	blup	15	0.03	7.9e-04	10.282	-8.8	1.8e-18	-0.89	0.00	0.95	FALSE
15	GTEx	Cells Transformed fibroblasts	C1QTNF4	0.13	0.11	enet	19	0.12	5.2e-09	9.209	-8.7	4.4e-18	-0.84	0.03	0.97	FALSE
14	GTEx	Cells Transformed fibroblasts	PSMC3	0.07	0.00	enet	13	0.02	2.3e-02	-5.357	8.6	8.7e-18	0.83	0.03	0.77	FALSE
82	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUP160	0.03	0.02	enet	7	0.02	6.3e-03	8.127	8.6	1.3e-17	0.83	0.01	0.89	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MADD	0.13	0.04	lasso	3	0.05	1.3e-02	8.344	8.5	1.5e-17	0.81	0.05	0.31	FALSE
78	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PSMC3	0.09	0.07	blup	39	0.06	8.7e-04	8.363	8.5	1.5e-17	0.85	0.01	0.98	FALSE
38	GTEx	Testis	C1QTNF4	0.14	0.12	lasso	4	0.11	1.6e-05	-8.749	-8.4	2.8e-17	-0.73	0.28	0.67	FALSE
25	GTEx	Liver	C1QTNF4	0.25	0.14	enet	16	0.20	2.3e-06	10.282	-8.4	3.0e-17	-0.84	0.02	0.97	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	FNBP4	0.04	0.04	lasso	3	0.04	8.2e-06	-8.766	8.4	3.0e-17	0.69	0.95	0.04	FALSE
72	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PSMC3	0.07	0.07	enet	7	0.06	1.4e-04	8.368	8.4	4.2e-17	0.82	0.01	0.98	FALSE
37	GTEx	Testis	MTCH2	0.17	0.16	lasso	3	0.16	1.0e-07	8.336	8.4	6.0e-17	0.83	0.52	0.48	FALSE
10	GTEx	Breast Mammary Tissue	C1QTNF4	0.10	0.06	lasso	2	0.03	8.5e-03	8.336	-8.2	2.1e-16	-0.82	0.10	0.68	FALSE
8	GTEx	Brain Cortex	MTCH2	0.21	0.19	lasso	6	0.16	4.0e-05	9.080	8.2	3.7e-16	0.79	0.35	0.18	FALSE
19	GTEx	Esophagus Muscularis	MTCH2	0.09	0.04	lasso	6	0.02	1.8e-02	9.209	8.1	5.0e-16	0.78	0.27	0.53	FALSE
22	GTEx	Heart Left Ventricle	MADD	0.14	0.01	enet	17	0.05	7.0e-04	-3.709	7.9	2.2e-15	0.70	0.02	0.96	FALSE
55	YFS	Blood	PTPMT1	0.03	0.01	lasso	5	0.01	3.2e-04	-8.722	-7.9	2.7e-15	-0.67	0.28	0.61	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	PSMC3	0.15	0.08	bslmm	285	0.10	5.1e-13	-4.745	7.9	3.8e-15	0.68	0.43	0.57	FALSE
73	The Cancer Genome Atlas	Brain Lower Grade Glioma	MADD	0.08	0.01	lasso	5	0.05	3.1e-06	8.416	7.8	6.6e-15	0.62	0.00	0.95	FALSE
83	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC3	0.02	0.02	blup	39	0.02	5.7e-03	8.336	7.7	1.0e-14	0.78	0.01	0.71	FALSE
42	METSIM	Adipose	MYBPC3	0.11	0.10	enet	26	0.11	1.0e-15	8.336	-7.7	1.6e-14	-0.81	0.31	0.69	FALSE
43	METSIM	Adipose	PSMC3	0.06	0.03	enet	28	0.04	2.3e-06	5.032	7.6	2.3e-14	0.79	0.03	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MTCH2	0.03	0.00	bslmm	299	0.00	1.1e-01	0.071	7.6	2.7e-14	0.68	0.07	0.53	FALSE
51	YFS	Blood	FNBP4	0.02	0.01	bslmm	301	0.01	8.9e-05	-5.264	7.5	6.5e-14	0.78	0.03	0.95	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	ACP2	0.03	0.00	blup	295	0.02	1.5e-03	8.416	7.4	1.5e-13	0.72	0.06	0.86	FALSE
75	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYBPC3	0.03	0.01	blup	43	0.02	3.2e-03	8.363	-7.3	2.7e-13	-0.72	0.00	0.90	FALSE
34	GTEx	Skin Sun Exposed Lower leg	PSMC3	0.20	0.05	lasso	7	0.10	1.2e-08	-5.357	7.3	2.8e-13	0.68	0.68	0.29	FALSE
29	GTEx	Nerve Tibial	SLC39A13	0.07	0.01	enet	14	0.02	7.6e-03	8.368	7.3	3.0e-13	0.70	0.13	0.34	FALSE
3	GTEx	Adipose Subcutaneous	ACP2	0.08	0.03	enet	18	0.03	3.5e-03	-4.356	7.2	8.4e-13	0.73	0.08	0.78	FALSE
7	GTEx	Brain Cerebellum	MADD	0.21	0.00	enet	13	0.11	3.3e-04	-3.002	6.9	4.6e-12	0.63	0.07	0.68	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	MYBPC3	0.02	0.01	blup	43	0.01	3.4e-03	8.297	-6.9	5.3e-12	-0.74	0.01	0.97	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PSMC3	0.05	0.04	lasso	3	0.05	3.8e-06	5.032	6.9	6.1e-12	0.73	0.02	0.98	FALSE
67	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MYBPC3	0.05	0.03	blup	43	0.04	6.0e-05	5.878	-6.8	1.5e-11	-0.71	0.01	0.98	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NUP160	0.08	0.03	blup	42	0.04	6.7e-05	9.013	6.7	1.7e-11	0.71	0.01	0.97	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	C1QTNF4	0.02	0.01	lasso	5	0.02	2.1e-04	-2.327	-6.7	2.4e-11	-0.74	0.01	0.83	FALSE
44	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	-0.473	-6.5	9.5e-11	-0.42	0.13	0.87	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	PSMC3	0.09	0.05	blup	39	0.05	1.0e-03	-3.017	6.4	2.0e-10	0.55	0.02	0.82	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	MADD	0.11	0.03	enet	14	0.06	1.4e-11	-3.448	6.3	2.6e-10	0.56	0.04	0.96	FALSE
56	YFS	Blood	SPI1	0.65	0.18	enet	75	0.27	1.6e-87	8.340	-6.3	2.7e-10	-0.62	1.00	0.00	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	LRP4	0.13	0.00	lasso	7	0.02	3.5e-02	-1.908	-6.2	6.5e-10	-0.60	0.04	0.73	FALSE
31	GTEx	Pituitary	MADD	0.42	0.32	lasso	6	0.39	8.9e-11	-2.131	6.1	1.2e-09	0.60	0.25	0.63	FALSE
40	METSIM	Adipose	ACP2	0.05	0.04	blup	302	0.06	1.7e-09	8.336	6.1	1.2e-09	0.67	0.34	0.66	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	MYBPC3	0.04	0.02	enet	10	0.04	2.9e-05	8.297	-6.0	2.1e-09	-0.68	0.01	0.98	FALSE
6	GTEx	Brain Cerebellar Hemisphere	MADD	0.44	0.14	lasso	7	0.21	4.0e-06	-4.356	6.0	2.4e-09	0.50	0.33	0.19	FALSE
52	YFS	Blood	NR1H3	0.34	0.15	enet	66	0.24	3.1e-76	-4.278	5.9	2.9e-09	0.56	1.00	0.00	FALSE
81	The Cancer Genome Atlas	Prostate Adenocarcinoma	AGBL2	0.04	0.03	blup	49	0.03	7.8e-04	-7.357	5.9	3.3e-09	0.41	0.18	0.07	FALSE
24	GTEx	Liver	PSMC3	0.15	0.09	lasso	4	0.07	5.9e-03	4.788	5.6	2.6e-08	0.59	0.09	0.10	FALSE
53	YFS	Blood	NUP160	0.02	0.01	blup	290	0.01	1.7e-04	9.057	5.5	3.8e-08	0.65	0.25	0.60	FALSE
12	GTEx	Breast Mammary Tissue (Female)	PSMC3	0.02	0.01	lasso	1	0.04	2.5e-02	-5.357	5.4	8.5e-08	0.53	0.02	0.18	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	MADD	0.07	0.00	enet	11	0.03	6.7e-04	-3.112	5.2	1.8e-07	0.36	0.05	0.13	FALSE