[Hub]/) : Traits : Leg fat percentage (left) : ← →

chr16:69,062,879-70,978,362

Best TWAS P=6.42e-16 · Best GWAS P=3.22e-13 conditioned to 0.989

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Brain Cerebellum	RP11-296I10.3	0.20	0.03	enet	12	0.14	8.8e-05	-5.11	-8.1	6.4e-16	-0.38	0.04	0.25	TRUE
70	The Cancer Genome Atlas	Breast Invasive Carcinoma	NQO1	0.02	0.01	blup	39	0.01	4.3e-03	4.55	5.4	5.7e-08	0.73	0.06	0.16	TRUE
88	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMED6	0.14	0.02	blup	37	0.03	2.6e-04	-2.96	5.3	1.0e-07	0.05	0.00	0.00	TRUE
16	GTEx	Brain Cerebellum	PDPR	0.23	0.06	enet	20	0.11	3.7e-04	-5.16	-7.6	3.0e-14	-0.33	0.07	0.21	FALSE
69	The Cancer Genome Atlas	Breast Invasive Carcinoma	NFAT5	0.02	0.01	enet	5	0.01	6.6e-04	3.90	7.2	6.7e-13	0.79	0.02	0.57	FALSE
26	GTEx	Breast Mammary Tissue (Female)	EXOSC6	0.52	0.26	enet	21	0.27	1.4e-08	-5.16	-7.1	9.2e-13	-0.36	0.69	0.16	FALSE
46	GTEx	Ovary	RP11-296I10.6	0.35	0.28	enet	18	0.27	2.2e-07	-5.16	-6.9	7.0e-12	-0.45	0.15	0.68	FALSE
92	The Cancer Genome Atlas	Stomach Adenocarcinoma	CLEC18A	0.07	0.05	blup	23	0.04	3.7e-04	-6.29	-6.8	1.4e-11	-0.40	0.01	0.97	FALSE
76	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CLEC18A	0.20	0.12	lasso	3	0.15	2.7e-16	-6.34	-6.5	6.6e-11	-0.36	0.00	1.00	FALSE
57	GTEx	Thyroid	NOB1	0.03	0.01	enet	6	0.02	7.7e-03	5.37	-6.4	1.3e-10	-0.70	0.23	0.27	FALSE
89	The Cancer Genome Atlas	Rectum Adenocarcinoma	CLEC18A	0.15	0.03	blup	23	0.09	4.3e-03	-4.07	-6.4	1.9e-10	-0.54	0.01	0.53	FALSE
86	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CLEC18A	0.20	0.14	enet	12	0.15	1.5e-06	-6.32	-6.3	2.4e-10	-0.39	0.01	0.99	FALSE
83	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CLEC18A	0.06	0.10	lasso	1	0.09	6.9e-11	-6.32	-6.3	2.6e-10	-0.42	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Soft Tissue Sarcoma	CLEC18A	0.12	0.11	lasso	2	0.11	3.4e-07	-6.31	-6.3	2.7e-10	-0.44	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Lung Adenocarcinoma	CLEC18A	0.13	0.17	enet	11	0.17	1.8e-19	-6.10	-6.3	2.9e-10	-0.39	0.01	0.99	FALSE
14	GTEx	Brain Cerebellar Hemisphere	EXOSC6	0.51	0.15	lasso	11	0.26	2.9e-07	-5.11	-6.3	3.5e-10	-0.35	0.36	0.46	FALSE
55	GTEx	Testis	WWP2	0.30	0.10	lasso	5	0.16	9.2e-08	4.77	6.2	6.0e-10	0.62	0.48	0.30	FALSE
72	The Cancer Genome Atlas	Colon Adenocarcinoma	CLEC18A	0.14	0.18	lasso	5	0.15	4.5e-09	-6.10	-6.2	6.0e-10	-0.43	0.01	0.99	FALSE
62	METSIM	Adipose	CLEC18A	0.26	0.18	lasso	15	0.27	4.4e-40	4.04	-6.2	6.7e-10	-0.31	1.00	0.00	FALSE
13	GTEx	Brain Cerebellar Hemisphere	PDXDC2P	0.33	0.16	enet	11	0.27	1.4e-07	-6.29	-6.1	9.2e-10	-0.37	0.50	0.25	FALSE
2	CommonMind	Brain Pre-frontal Cortex	WWP2	0.10	0.04	bslmm	274	0.06	4.4e-08	-6.10	6.1	1.0e-09	0.32	0.77	0.22	FALSE
71	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CLEC18A	0.10	0.06	lasso	2	0.04	6.3e-03	-6.10	-6.1	1.1e-09	-0.42	0.01	0.82	FALSE
74	The Cancer Genome Atlas	Glioblastoma Multiforme	PDXDC2	0.10	0.12	lasso	3	0.10	4.7e-04	-6.10	-6.1	1.1e-09	-0.42	0.01	0.82	FALSE
21	GTEx	Brain Nucleus accumbens basal ganglia	RP11-296I10.6	0.15	0.11	lasso	3	0.08	3.0e-03	-5.07	-6.0	1.7e-09	-0.31	0.12	0.13	FALSE
36	GTEx	Heart Atrial Appendage	RP11-296I10.6	0.18	0.19	enet	16	0.16	1.1e-07	-5.11	-6.0	2.2e-09	-0.23	0.98	0.01	FALSE
58	GTEx	Thyroid	CTD-2033A16.3	0.03	0.02	enet	7	0.02	6.7e-03	4.29	-6.0	2.8e-09	-0.68	0.20	0.30	FALSE
85	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CLEC18A	0.21	0.08	blup	23	0.12	9.8e-06	-4.07	-5.9	4.0e-09	-0.32	0.01	0.89	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	CLEC18A	0.24	0.26	blup	23	0.27	1.3e-26	-6.29	-5.9	4.3e-09	-0.36	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Breast Invasive Carcinoma	CLEC18A	0.16	0.17	enet	10	0.19	6.8e-37	-6.10	-5.8	5.2e-09	-0.39	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	EXOSC6	0.27	0.28	enet	26	0.32	3.1e-27	-5.07	-5.8	6.2e-09	-0.27	1.00	0.00	FALSE
29	GTEx	Cells Transformed fibroblasts	RP11-296I10.6	0.10	0.09	enet	9	0.10	6.1e-08	-5.11	-5.8	7.7e-09	-0.24	0.99	0.01	FALSE
82	The Cancer Genome Atlas	Lung Adenocarcinoma	PDXDC2	0.10	0.10	blup	26	0.11	6.7e-13	4.17	-5.8	8.8e-09	-0.31	0.14	0.86	FALSE
91	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CLEC18A	0.17	0.09	enet	8	0.11	8.5e-04	-4.07	-5.7	9.2e-09	-0.49	0.01	0.77	FALSE
67	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PDXDC2	0.06	0.02	blup	26	0.06	9.7e-06	-6.29	-5.7	1.2e-08	-0.36	0.02	0.96	FALSE
38	GTEx	Liver	EXOSC6	0.31	0.22	lasso	10	0.11	6.9e-04	-5.34	5.7	1.4e-08	0.24	0.34	0.12	FALSE
84	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDXDC2	0.09	0.05	blup	26	0.07	2.5e-08	-4.05	-5.7	1.6e-08	-0.35	0.02	0.98	FALSE
27	GTEx	Breast Mammary Tissue (Female)	RP11-296I10.6	0.18	0.17	enet	8	0.13	1.0e-04	-5.16	-5.6	1.7e-08	-0.25	0.33	0.08	FALSE
44	GTEx	Ovary	PDXDC2P	0.45	0.11	lasso	7	0.28	1.6e-07	3.77	-5.6	1.7e-08	-0.31	0.50	0.16	FALSE
64	ROSMAP	Brain Pre-frontal Cortex	RP11-296I10.6	0.36	0.42	enet	19	0.42	6.7e-59	-5.10	-5.6	1.8e-08	-0.22	1.00	0.00	FALSE
93	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CLEC18A	0.20	0.09	lasso	5	0.08	8.8e-04	-5.61	-5.6	1.9e-08	-0.53	0.04	0.50	FALSE
78	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EXOSC6	0.17	0.17	enet	5	0.17	9.2e-10	-5.10	-5.6	2.3e-08	-0.22	0.00	1.00	FALSE
63	NTR	Blood	EXOSC6	0.06	0.07	bslmm	195	0.07	2.7e-22	-5.07	-5.6	2.6e-08	-0.24	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AARS	0.02	0.01	enet	4	0.01	5.3e-02	-5.10	5.5	3.1e-08	0.13	0.00	0.54	FALSE
73	The Cancer Genome Atlas	Esophageal Carcinoma	CLEC18A	0.19	0.04	blup	23	0.10	3.6e-04	-6.32	-5.5	3.2e-08	-0.33	0.01	0.64	FALSE
6	GTEx	Adrenal Gland	EXOSC6	0.22	0.18	enet	6	0.17	1.1e-06	-5.07	-5.5	3.6e-08	-0.21	0.82	0.01	FALSE
24	GTEx	Breast Mammary Tissue	RP11-296I10.6	0.31	0.30	enet	17	0.30	7.1e-16	-5.19	-5.5	3.7e-08	-0.17	1.00	0.00	FALSE
87	The Cancer Genome Atlas	Prostate Adenocarcinoma	CLEC18A	0.08	0.02	blup	23	0.04	8.4e-05	-4.07	-5.5	3.9e-08	-0.35	0.01	0.84	FALSE
43	GTEx	Nerve Tibial	RP11-296I10.6	0.32	0.40	enet	23	0.43	5.1e-33	-5.07	-5.5	4.4e-08	-0.22	1.00	0.00	FALSE
54	GTEx	Stomach	RP11-296I10.6	0.24	0.15	enet	14	0.16	4.5e-08	-5.11	-5.5	4.4e-08	-0.21	0.99	0.00	FALSE
81	The Cancer Genome Atlas	Lung Adenocarcinoma	EXOSC6	0.09	0.13	enet	5	0.13	4.2e-15	-5.10	-5.5	4.5e-08	-0.21	0.00	1.00	FALSE
5	GTEx	Adipose Visceral Omentum	EXOSC6	0.26	0.29	lasso	6	0.32	3.3e-17	-5.07	-5.5	4.7e-08	-0.24	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDXDC2	0.15	0.25	enet	12	0.29	8.2e-33	-4.09	-5.5	4.9e-08	-0.36	0.07	0.93	FALSE
30	GTEx	Colon Sigmoid	RP11-296I10.6	0.32	0.33	enet	20	0.33	2.2e-12	-5.11	-5.5	5.0e-08	-0.19	1.00	0.00	FALSE
66	YFS	Blood	PDPR	0.02	0.00	enet	20	0.01	1.8e-05	0.48	5.4	5.3e-08	0.55	0.03	0.52	FALSE
41	GTEx	Muscle Skeletal	RP11-296I10.6	0.11	0.15	enet	16	0.15	1.8e-14	-5.07	-5.4	6.2e-08	-0.26	1.00	0.00	FALSE
1	CommonMind	Brain Pre-frontal Cortex	EXOSC6	0.24	0.25	enet	14	0.24	1.5e-29	-5.10	-5.4	6.3e-08	-0.24	1.00	0.00	FALSE
65	YFS	Blood	EXOSC6	0.24	0.24	lasso	5	0.25	2.4e-81	-5.07	-5.4	7.1e-08	-0.22	1.00	0.00	FALSE
52	GTEx	Spleen	PDXDC2P	0.44	0.26	lasso	5	0.29	4.6e-08	-5.39	-5.4	7.3e-08	-0.19	0.68	0.05	FALSE
11	GTEx	Artery Tibial	EXOSC6	0.27	0.32	enet	10	0.30	5.5e-24	-5.11	-5.4	7.5e-08	-0.21	1.00	0.00	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	EXOSC6	0.22	0.12	enet	12	0.12	3.3e-04	-5.16	-5.3	9.3e-08	-0.30	0.28	0.10	FALSE
28	GTEx	Cells Transformed fibroblasts	EXOSC6	0.18	0.19	enet	12	0.23	2.1e-17	-5.16	-5.3	9.5e-08	-0.23	1.00	0.00	FALSE
8	GTEx	Artery Coronary	EXOSC6	0.29	0.24	enet	10	0.20	2.1e-07	-5.07	-5.3	1.0e-07	-0.18	0.99	0.01	FALSE
15	GTEx	Brain Cerebellar Hemisphere	RP11-296I10.6	0.19	0.20	lasso	5	0.19	1.5e-05	-5.16	-5.3	1.1e-07	-0.18	0.31	0.13	FALSE
50	GTEx	Skin Not Sun Exposed Suprapubic	RP11-296I10.6	0.21	0.24	enet	17	0.24	1.4e-13	-5.11	-5.3	1.2e-07	-0.20	1.00	0.00	FALSE
22	GTEx	Brain Putamen basal ganglia	RP11-296I10.6	0.24	0.01	enet	18	0.04	3.2e-02	-6.34	-5.3	1.3e-07	-0.30	0.19	0.22	FALSE
25	GTEx	Breast Mammary Tissue (Male)	RP11-296I10.6	0.32	0.42	lasso	8	0.47	1.8e-12	-5.07	-5.3	1.3e-07	-0.15	0.95	0.01	FALSE
31	GTEx	Colon Transverse	EXOSC6	0.32	0.31	enet	8	0.31	2.1e-15	-5.07	-5.3	1.4e-07	-0.19	1.00	0.00	FALSE
40	GTEx	Muscle Skeletal	EXOSC6	0.28	0.32	enet	20	0.32	4.2e-32	-5.11	-5.3	1.4e-07	-0.24	1.00	0.00	FALSE
47	GTEx	Pancreas	EXOSC6	0.38	0.36	lasso	4	0.34	7.3e-15	-5.39	-5.3	1.4e-07	-0.19	0.99	0.01	FALSE
56	GTEx	Testis	RP11-296I10.6	0.10	0.04	enet	7	0.07	6.2e-04	-5.11	-5.3	1.4e-07	-0.23	0.18	0.05	FALSE
60	GTEx	Whole Blood	EXOSC6	0.14	0.12	enet	10	0.11	3.5e-10	-5.19	-5.3	1.4e-07	-0.21	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RP11-296I10.6	0.30	0.27	lasso	7	0.31	8.4e-26	-5.11	-5.2	1.5e-07	-0.22	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue	EXOSC6	0.38	0.34	enet	8	0.34	2.0e-18	-5.07	-5.2	1.5e-07	-0.16	1.00	0.00	FALSE
77	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	AARS	0.05	0.02	enet	6	0.03	9.8e-03	-5.10	5.2	1.5e-07	0.20	0.00	0.53	FALSE
42	GTEx	Nerve Tibial	EXOSC6	0.28	0.37	enet	10	0.41	1.1e-30	-5.07	-5.2	1.6e-07	-0.19	1.00	0.00	FALSE
51	GTEx	Skin Sun Exposed Lower leg	EXOSC6	0.21	0.21	enet	10	0.22	3.9e-18	-5.11	-5.2	1.6e-07	-0.22	1.00	0.00	FALSE
33	GTEx	Esophagus Muscularis	EXOSC6	0.30	0.33	enet	13	0.37	6.7e-24	-5.11	-5.2	1.7e-07	-0.18	1.00	0.00	FALSE
59	GTEx	Uterus	PDXDC2P	0.31	0.20	enet	28	0.24	1.3e-05	-3.83	-5.2	1.9e-07	-0.29	0.08	0.32	FALSE
19	GTEx	Brain Cerebellum	RP11-296I10.6	0.18	0.21	lasso	2	0.18	5.8e-06	-5.07	-5.2	2.0e-07	-0.21	0.63	0.08	FALSE
34	GTEx	Esophagus Muscularis	RP11-296I10.6	0.32	0.27	enet	24	0.32	4.0e-20	-5.07	-5.2	2.0e-07	-0.14	1.00	0.00	FALSE
45	GTEx	Ovary	EXOSC6	0.32	-0.01	enet	34	0.09	2.7e-03	-4.04	-5.2	2.0e-07	-0.47	0.06	0.26	FALSE
61	GTEx	Whole Blood	RP11-296I10.6	0.08	0.07	enet	16	0.09	2.3e-08	-5.19	-5.2	2.0e-07	-0.24	0.99	0.00	FALSE
7	GTEx	Artery Aorta	EXOSC6	0.36	0.32	enet	8	0.34	1.8e-19	-5.07	-5.2	2.1e-07	-0.19	1.00	0.00	FALSE
12	GTEx	Artery Tibial	RP11-296I10.6	0.27	0.37	enet	11	0.38	4.3e-31	-5.07	-5.2	2.2e-07	-0.16	1.00	0.00	FALSE
37	GTEx	Heart Left Ventricle	EXOSC6	0.33	0.35	enet	18	0.34	4.0e-19	-5.34	-5.2	2.2e-07	-0.18	0.99	0.01	FALSE
9	GTEx	Artery Tibial	PDXDC2P	0.31	0.16	enet	24	0.19	6.3e-15	-5.39	-5.2	2.3e-07	-0.25	1.00	0.00	FALSE
48	GTEx	Prostate	EXOSC6	0.31	0.24	lasso	6	0.23	2.2e-06	-5.11	-5.2	2.3e-07	-0.19	0.49	0.03	FALSE
17	GTEx	Brain Cerebellum	PDXDC2P	0.39	0.20	lasso	8	0.32	2.7e-10	3.77	-5.2	2.4e-07	-0.24	0.81	0.17	FALSE
32	GTEx	Esophagus Mucosa	EXOSC6	0.12	0.20	enet	5	0.19	1.6e-12	-5.07	-5.2	2.4e-07	-0.18	1.00	0.00	FALSE
35	GTEx	Heart Atrial Appendage	EXOSC6	0.26	0.30	enet	12	0.32	9.7e-15	-5.34	-5.2	2.5e-07	-0.19	0.99	0.01	FALSE
53	GTEx	Stomach	EXOSC6	0.36	0.28	enet	9	0.26	1.6e-12	-5.11	-5.2	2.5e-07	-0.21	1.00	0.00	FALSE
10	GTEx	Artery Tibial	WWP2	0.13	0.01	enet	17	0.02	4.9e-03	-6.34	5.2	2.6e-07	0.29	0.44	0.17	FALSE
39	GTEx	Lung	EXOSC6	0.34	0.40	enet	8	0.39	9.6e-32	-5.34	-5.2	2.6e-07	-0.18	0.99	0.01	FALSE
49	GTEx	Skin Not Sun Exposed Suprapubic	EXOSC6	0.21	0.22	lasso	2	0.22	3.6e-12	-5.16	5.1	2.7e-07	0.20	1.00	0.00	FALSE