TWAS hub - TMED6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.2200	0.0680	1.6e-05	0.232	NA	0.163	NA	0.213	2.4e-11	NA	3.4e-08	NA	1.9e-10
2	GTEx	Esophagus Muscularis	0.0750	0.0320	1.2e-03	0.039	NA	0.062	NA	0.047	2.0e-03	NA	1.2e-04	NA	7.5e-04
3	GTEx	Liver	0.3680	0.0920	2.4e-06	0.223	NA	0.161	NA	0.244	7.1e-07	NA	3.1e-05	NA	1.9e-07
4	GTEx	Pancreas	0.7300	0.0510	0.0e+00	0.638	NA	0.566	NA	0.629	2.9e-34	NA	2.0e-28	NA	1.9e-33
5	GTEx	Spleen	0.1670	0.0810	6.1e-03	0.001	NA	0.023	NA	0.067	3.0e-01	NA	8.3e-02	NA	8.7e-03
6	GTEx	Stomach	0.5430	0.0730	8.5e-14	0.417	NA	0.391	NA	0.409	1.5e-21	NA	5.7e-20	NA	4.8e-21
7	GTEx	Testis	0.1850	0.0690	6.9e-04	0.081	NA	0.013	NA	0.046	1.8e-04	NA	8.4e-02	NA	4.2e-03
8	METSIM	Adipose	0.1051	0.0334	4.5e-06	0.059	0.041	0.069	0.053	0.069	3.4e-09	7.9e-07	1.5e-10	2.3e-08	1.4e-10
9	TCGA	Bladder Urothelial Carcinoma	0.0670	0.0340	3.4e-04	0.014	0.035	0.037	NA	0.035	2.3e-02	6.2e-04	3.7e-04	NA	5.5e-04
10	TCGA	Colon Adenocarcinoma	0.3660	0.0810	5.6e-17	0.289	0.244	0.256	NA	0.276	5.0e-17	2.7e-14	5.4e-15	NA	3.2e-16
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.4666	0.0826	0.0e+00	0.314	0.336	0.360	NA	0.366	6.0e-36	6.1e-39	3.1e-42	NA	3.6e-43
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.3090	0.0870	1.7e-10	0.193	0.194	0.191	NA	0.198	3.0e-11	2.5e-11	3.9e-11	NA	1.5e-11
13	TCGA	Liver Hepatocellular Carcinoma	0.2090	0.0750	2.1e-06	0.063	0.142	0.145	NA	0.125	6.4e-04	3.4e-07	2.5e-07	NA	1.7e-06
14	TCGA	Lung Adenocarcinoma	0.2777	0.0613	0.0e+00	0.202	0.237	0.253	NA	0.244	3.8e-23	2.4e-27	2.1e-29	NA	2.8e-28
15	TCGA	Lung Squamous Cell Carcinoma	0.0761	0.0377	4.5e-04	0.030	0.032	0.029	NA	0.026	2.1e-04	1.4e-04	3.0e-04	NA	5.0e-04
16	TCGA	Pancreatic Adenocarcinoma	0.3580	0.0950	1.3e-07	0.175	0.227	0.230	NA	0.190	8.4e-08	6.2e-10	4.7e-10	NA	2.1e-08
17	TCGA	Prostate Adenocarcinoma	0.1371	0.0607	9.9e-04	0.016	0.032	0.026	NA	0.026	7.0e-03	2.6e-04	8.5e-04	NA	9.1e-04
18	TCGA	Rectum Adenocarcinoma	0.5470	0.1370	8.3e-05	0.073	0.117	0.129	NA	0.102	8.7e-03	1.1e-03	6.4e-04	NA	2.3e-03
19	TCGA	Stomach Adenocarcinoma	0.1840	0.0650	1.3e-09	0.137	0.132	0.153	NA	0.136	4.3e-10	8.8e-10	3.2e-11	NA	4.5e-10
20	TCGA	Thyroid Carcinoma	0.1170	0.0450	1.7e-05	0.046	0.045	0.046	NA	0.042	2.5e-05	2.9e-05	2.7e-05	NA	5.2e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20
Mean Putamen Volume	11.8	13.4	18.2	3.5	3.2	3.4	3.7	3.2	3.7	3.3	4.3	2.1	3.6	4.2	3.8	4.2	4.0	3.9	4.0	3.5	3.8	3.8	3.5
Bipolar Disorder or Schizophrenia	6.6	16.1	25.1	4.1	3.7	4.2	4.2	3.7	3.9	3.9	4.1	4.8	4.2	4.5	4.2	4.1	4.4	3.5	3.6	1.5	4.2	5.0	3.2
Severe depression (siblings)	6.1	6.8	11.2	2.2	2.4	2.6	2.4	3.2	2.1	2.0	2.8	2.6	2.4	2.8	2.4	3.3	2.6	2.7	2.9	2.2	3.0	3.4	1.6
Alcohol intake frequency.	5.9	13.7	27.9	4.1	5.3	3.7	4.0	3.8	3.8	3.7	3.2	4.1	4.1	4.2	4.0	3.8	3.6	2.4	2.8	2.2	3.4	4.0	2.6
Forced vital capacity (FVC), Best measure	5.5	20.1	38.7	-4.6	-6.2	-5.3	-4.6	-4.2	-4.8	-4.7	-4.2	-3.5	-4.8	-4.8	-4.6	-5.2	-4.2	-3.4	-4.2	-3.8	-4.1	-4.1	-3.0
Bipolar Disorder (2018)	5.3	8.3	12.0	2.9	2.6	3.5	2.9	3.0	2.6	2.7	3.1	3.0	3.0	3.2	3.0	3.3	3.1	2.2	2.6	1.5	3.0	3.3	2.6
Forced expiratory volume in 1-second (FEV1), Best measure	5.1	16.4	30.3	-4.1	-5.5	-4.6	-4.2	-4.1	-4.1	-3.9	-4.0	-3.2	-4.2	-4.4	-4.2	-4.5	-4.1	-3.3	-3.9	-3.2	-3.9	-3.8	-2.9
Osteoarthritis (self-reported)	4.6	6.0	12.0	2.3	1.5	1.3	2.5	2.0	2.5	1.7	2.8	1.8	2.3	2.9	2.5	2.7	2.5	2.9	2.9	3.5	2.2	2.8	2.1
Shortness of breath walking on level ground	4.5	5.3	7.4	2.3	2.0	2.1	2.5	1.4	2.4	2.3	2.4	1.9	2.5	2.6	2.5	2.2	2.6	2.7	2.6	1.3	2.5	2.6	2.0
Sitting height	4.4	31.4	63.8	-6.0	-8.0	-6.8	-5.8	-5.4	-5.9	-5.3	-4.7	-6.2	-6.2	-6.0	-5.8	-6.3	-5.1	-3.2	-4.3	-2.9	-6.0	-5.9	-3.5
Hearing aid user	4.4	4.9	7.4	2.3	2.6	2.4	2.3	2.1	2.1	1.6	2.0	2.7	2.4	2.3	2.3	2.7	2.0	1.8	2.2	1.8	2.5	2.4	1.5
Forced vital capacity (FVC)	4.2	16.2	32.2	-4.1	-5.7	-4.9	-4.2	-4.0	-4.3	-3.9	-3.6	-3.6	-4.3	-4.5	-4.1	-4.6	-3.9	-3.0	-3.6	-3.0	-4.1	-3.8	-2.6
Seen a psychiatrist for nerves, anxiety, tension or depression	4.1	5.3	10.0	2.4	2.4	2.9	2.3	2.4	2.2	1.7	2.2	3.2	2.6	2.2	2.4	2.6	1.7	1.3	2.1	0.4	3.0	2.6	1.4
Smoking status: Current	4.1	6.5	12.8	2.0	2.0	0.8	2.3	2.9	2.1	1.1	2.6	2.5	1.9	3.2	2.3	2.7	3.6	3.2	2.6	3.0	2.9	3.1	2.3
Forced expiratory volume in 1-second (FEV1)	4.0	13.4	25.9	-3.7	-5.1	-4.4	-3.7	-3.8	-3.7	-3.3	-3.5	-3.2	-3.9	-4.1	-3.8	-4.1	-3.8	-3.0	-3.4	-2.3	-3.8	-3.5	-2.3
Schizophrenia (2018)	3.9	8.0	14.2	2.9	2.7	2.7	3.0	2.4	2.9	2.8	2.7	3.7	3.0	3.2	2.9	2.6	3.1	2.6	2.6	0.8	2.9	3.8	2.0
Body mass index (BMI)	3.9	16.7	41.7	3.7	4.7	2.0	4.0	3.9	4.2	3.1	4.0	1.3	3.4	4.9	3.9	4.1	5.3	4.0	4.3	6.5	4.3	3.1	4.2
Peak expiratory flow (PEF)	3.8	8.8	14.7	-2.8	-3.5	-3.6	-3.0	-3.1	-2.6	-2.6	-3.3	-2.1	-3.2	-3.4	-3.1	-3.8	-3.1	-3.2	-3.0	-1.8	-2.5	-2.9	-1.8
Bilateral oophorectomy (both ovaries removed)	3.7	4.3	7.5	-2.7	-2.3	-2.4	-2.6	0.2	-2.6	-2.4	-1.7	-2.0	-2.6	-2.1	-2.5	-1.3	-2.0	-1.4	-1.9	-1.0	-1.7	-1.7	-2.2
Chronic bronchitis/emphysema (father)	3.7	4.4	12.2	2.1	3.4	2.1	2.0	3.5	1.8	1.1	1.7	3.2	2.1	2.2	1.9	1.8	1.5	0.8	1.5	0.6	2.2	2.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.7	4.3	7.1	-2.2	-1.6	-2.7	-2.2	-0.8	-2.1	-2.4	-2.0	-2.0	-2.3	-2.1	-2.2	-2.1	-1.9	-2.2	-2.3	-1.1	-2.1	-2.6	-1.6
Standing height	3.6	35.8	74.5	-6.3	-8.6	-7.3	-6.2	-5.4	-6.3	-6.1	-5.1	-6.2	-6.5	-6.4	-6.2	-6.9	-5.8	-3.8	-4.5	-3.4	-6.3	-5.8	-4.0
Current tobacco smoking	3.5	5.7	11.3	1.9	2.0	0.7	2.2	2.6	2.0	1.1	2.4	2.2	1.8	2.9	2.1	2.5	3.4	2.9	2.4	3.1	2.7	2.8	2.3
Long-standing illness, disability or infirmity	3.4	5.3	9.4	2.0	1.8	1.5	2.2	2.5	2.3	1.7	2.8	-0.0	2.0	2.8	2.2	2.2	3.1	2.5	3.0	3.0	2.5	1.7	2.2
Schizophrenia (2014)	3.2	7.1	14.4	2.7	2.0	2.2	2.8	2.3	2.6	2.1	2.5	3.8	2.6	3.1	2.7	2.2	3.2	2.6	2.4	0.5	3.3	3.8	2.1
Average weekly red wine intake	3.2	4.7	7.5	-2.3	-2.7	-2.1	-2.4	-2.0	-2.1	-2.0	-1.9	-2.4	-2.4	-2.6	-2.3	-2.6	-2.0	-1.7	-1.8	-2.0	-1.8	-2.5	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	3.2	3.5	5.4	2.1	0.6	1.7	2.1	0.6	1.9	1.9	2.1	1.9	2.2	2.1	2.2	2.1	2.0	1.8	1.7	0.7	1.5	2.1	2.3
Arm fat percentage (right)	3.1	12.3	36.5	3.2	3.8	1.9	3.5	3.0	3.7	2.7	3.4	0.3	3.0	4.3	3.4	3.4	4.5	3.7	3.9	6.0	3.1	2.3	3.5
Arm fat percentage (left)	3.1	12.5	34.8	3.3	4.0	2.0	3.6	3.0	3.8	2.7	3.5	0.6	3.1	4.3	3.5	3.3	4.5	3.7	3.9	5.9	3.1	2.4	3.4
BMI	2.9	16.6	38.6	3.4	5.1	2.7	3.7	4.3	4.0	3.5	4.2	0.3	3.3	4.6	3.8	4.2	5.5	3.5	4.0	6.2	4.7	2.2	4.6
Illnesses of mother	2.9	3.6	8.0	2.0	0.2	1.6	2.1	0.3	2.1	1.6	2.1	1.7	1.9	2.0	2.1	1.6	2.3	2.4	2.0	1.9	1.4	1.5	2.8
Loud music exposure frequency	2.9	3.1	6.8	-1.6	-1.5	-2.0	-1.6	-2.1	-1.5	-1.3	-2.1	-1.9	-1.9	-1.8	-1.8	-2.6	-1.3	-1.4	-1.7	-0.4	-2.5	-2.1	-1.0
Supplements: Glucosamine	2.8	3.6	8.0	1.8	1.8	2.1	1.8	2.3	1.7	1.5	1.9	2.8	1.9	2.0	1.8	2.4	1.4	1.1	1.6	0.6	2.4	2.8	0.8
Ulcerative Colitis (UC)	2.7	5.1	8.2	2.9	1.8	2.8	2.7	0.8	2.7	2.9	2.0	2.7	2.9	2.3	2.7	1.9	2.2	1.2	1.8	0.7	1.8	2.1	2.3
Leg fat percentage (left)	2.7	9.9	28.3	2.9	3.9	1.7	3.1	2.9	3.3	2.1	2.8	1.3	2.7	3.8	3.0	3.1	3.8	3.0	3.3	5.3	3.6	2.4	2.8
Leg fat percentage (right)	2.6	9.3	28.6	2.7	4.2	1.6	3.0	3.1	3.1	1.9	2.6	1.2	2.5	3.6	2.8	2.9	3.6	2.7	3.2	5.3	3.5	2.2	2.5
Impedance of whole body	2.6	13.1	26.1	-3.7	-3.1	-2.4	-3.8	-2.7	-4.0	-3.6	-3.8	-2.2	-3.5	-4.0	-3.9	-3.6	-4.8	-3.2	-3.3	-3.8	-3.8	-2.8	-5.1
Knee pain experienced in last month	2.5	3.9	7.1	1.8	1.6	0.7	2.0	1.9	2.0	1.5	1.8	2.5	1.7	2.3	1.9	1.8	2.0	2.2	2.2	2.1	2.4	2.7	1.3
Height	2.4	45.7	97.0	-7.2	-9.8	-8.0	-7.0	-5.9	-7.3	-6.5	-5.3	-7.6	-7.3	-7.2	-7.0	-7.4	-6.7	-4.0	-4.9	-3.0	-8.1	-7.1	-4.4
Medication for hormone replacement therapy	2.4	2.7	6.2	-2.1	-2.3	-2.1	-1.9	-0.8	-2.1	-2.5	-1.4	-1.5	-2.0	-1.5	-2.0	-1.0	-1.6	-0.2	-1.0	-0.1	-1.3	-0.9	-1.7
Serious illness, injury or assault to yourself	2.4	2.9	9.3	1.6	3.1	1.0	1.7	1.9	1.7	1.2	1.4	0.9	1.7	2.0	1.7	1.8	1.9	1.5	1.6	1.7	2.0	1.7	1.1
Bipolar Disorder (2011)	2.3	2.2	4.7	1.5	0.2	1.4	1.5	0.8	1.4	1.6	2.1	0.8	1.6	1.5	1.7	1.1	2.0	1.5	1.8	0.5	1.6	1.3	2.2
Impedance of leg (right)	2.3	11.2	25.5	-3.5	-1.9	-2.0	-3.7	-1.8	-3.9	-3.5	-3.7	-1.5	-3.4	-3.8	-3.7	-3.0	-4.7	-3.5	-3.2	-3.3	-2.8	-2.5	-5.0
Arm fat mass (right)	2.3	9.5	35.6	2.5	3.0	0.8	2.9	2.9	3.1	2.0	3.1	-0.1	2.3	3.7	2.8	2.8	4.2	3.4	3.5	6.0	2.9	1.9	3.4
Handedness (chirality/laterality): Left-handed	2.3	2.7	9.6	-0.9	-2.8	-1.8	-1.0	-3.1	-0.6	-1.1	-1.8	-0.8	-1.1	-1.5	-1.2	-2.5	-1.9	-1.1	-1.1	-1.8	-1.9	-1.3	-1.2
Medication: Atorvastatin	2.3	2.8	6.5	1.0	0.7	1.0	1.2	2.2	1.3	1.6	2.1	-0.3	1.1	1.8	1.3	1.7	2.3	2.2	2.4	2.5	1.9	1.0	1.7
Ulcerative Colitis	2.2	3.2	8.4	2.1	1.5	2.4	1.9	0.8	1.9	2.9	1.9	1.4	2.2	1.7	2.1	1.9	1.6	1.1	1.5	0.3	1.6	1.4	2.1
Impedance of leg (left)	2.2	10.8	23.6	-3.4	-2.4	-1.9	-3.6	-2.2	-3.7	-3.5	-3.7	-1.3	-3.2	-3.7	-3.6	-2.9	-4.6	-3.2	-3.2	-3.5	-2.8	-2.3	-4.9
Irritable Bowel Disease (IBD)	2.1	5.0	9.7	2.8	1.4	2.1	2.7	-0.3	2.9	3.1	2.2	1.5	2.8	2.4	2.8	1.4	2.7	1.9	2.0	1.4	1.2	1.5	3.0
Forced expiratory volume in 1-second (FEV1), predicted	2.1	4.3	7.7	-2.4	-1.9	-2.7	-2.3	-0.9	-2.4	-2.8	-2.4	-1.1	-2.5	-2.1	-2.5	-2.1	-2.1	-1.4	-1.9	-0.6	-2.3	-1.4	-2.0
Ever had prostate specific antigen (PSA) test	2.1	2.4	4.5	1.7	1.0	2.0	1.7	0.9	1.6	1.7	1.7	1.5	2.0	1.5	1.8	2.1	0.9	1.3	1.8	1.0	1.5	1.5	1.0
Smoking Status	2.0	4.7	17.1	1.8	1.6	-0.0	2.1	1.4	2.2	0.9	2.0	1.3	1.5	2.8	1.9	1.6	2.8	3.1	2.7	4.1	2.0	2.3	1.8
Other serious medical condition/disability diagnosed by doctor	2.0	2.5	4.1	1.8	0.6	1.1	1.9	0.5	1.9	1.2	1.7	1.7	1.8	1.9	1.8	1.4	1.6	1.9	1.8	1.2	1.4	2.0	1.4
Medication: Simvastatin	2.0	2.9	6.2	1.8	1.1	1.5	1.9	0.9	2.0	1.2	1.9	0.1	1.8	2.0	1.9	1.9	1.7	1.7	2.2	2.5	1.6	1.0	2.0
Number of children fathered	2.0	2.3	5.9	-2.0	-2.4	-2.3	-1.8	-0.1	-2.2	-2.1	-1.0	-0.8	-2.0	-1.4	-1.8	-1.2	-1.1	-0.5	-1.1	-0.9	-0.9	-0.8	-1.0
Irritability	2.0	3.5	16.7	0.6	2.1	0.4	0.8	4.1	0.4	-0.2	1.9	1.9	0.9	1.8	0.9	2.7	1.1	2.2	2.2	1.7	2.5	2.8	-0.4
Age started oral contraceptive pill	2.0	2.5	15.9	-0.5	-3.0	-0.8	-0.7	-4.0	-0.5	-0.1	-1.4	-1.1	-0.7	-1.4	-0.8	-2.1	-1.3	-0.6	-1.1	-0.9	-2.5	-1.8	0.4
Diabetes (father)	1.9	2.4	4.2	1.9	1.4	0.9	1.9	1.2	1.9	1.4	1.3	1.9	1.8	2.0	1.8	1.5	1.3	1.4	1.3	1.1	0.8	1.9	1.2
Ever had bowel cancer screening	1.9	2.3	14.9	-0.9	-3.9	-1.3	-0.9	-3.1	-0.7	-0.5	-0.4	-1.9	-0.9	-1.3	-0.8	-1.6	-1.2	-0.1	-0.3	-0.3	-2.0	-1.5	0.1
Arm fat mass (left)	1.9	8.0	32.9	2.3	2.8	0.7	2.7	2.4	2.8	1.7	2.8	-0.3	2.0	3.5	2.5	2.4	3.9	3.2	3.2	5.7	2.4	1.6	3.1
Body Mass Index (BMI) (2010)	1.8	2.4	5.2	1.0	1.5	1.1	1.2	1.0	1.2	1.3	2.0	-0.4	1.1	1.7	1.4	1.7	2.3	2.2	1.9	2.2	1.7	1.0	1.9
Hip circumference	1.8	7.8	24.4	2.2	3.0	0.7	2.6	2.9	2.6	1.8	2.8	0.4	2.0	3.3	2.5	2.8	3.8	3.0	3.0	4.9	2.9	2.1	3.2
Medication: Cholesterol lowering	1.8	2.9	9.8	1.2	1.1	0.7	1.5	2.1	1.4	1.0	2.1	-0.9	1.3	1.9	1.5	2.0	2.0	1.8	2.3	3.1	1.4	0.8	1.6
Medication: Lansoprazole	1.8	2.1	6.5	-1.5	-1.8	-2.6	-1.3	-0.5	-1.1	-1.5	-1.0	-1.8	-1.7	-1.1	-1.4	-2.0	-0.9	-0.4	-0.7	0.8	-2.0	-1.6	-0.9
Leg pain on walking	1.8	2.3	5.8	0.8	1.6	1.0	1.0	2.1	0.6	0.5	1.4	2.1	1.0	1.6	1.0	2.2	1.5	1.6	1.3	1.0	2.4	2.4	0.3
Waist circumference	1.7	6.2	19.4	2.0	1.9	0.4	2.3	2.0	2.5	1.7	2.7	-0.1	1.8	3.0	2.3	2.3	3.4	2.9	2.9	4.4	2.7	1.7	3.0
Father’s age at death	1.7	2.2	4.5	1.4	1.0	2.1	1.4	1.2	1.4	1.4	1.8	1.2	1.6	1.4	1.5	1.9	1.1	1.2	1.7	0.5	2.1	1.8	0.9
Impedance of arm (left)	1.7	7.7	13.4	-2.7	-2.9	-1.8	-2.8	-2.7	-2.8	-2.5	-2.7	-2.3	-2.5	-3.0	-2.8	-3.1	-3.5	-2.0	-2.2	-3.2	-3.4	-2.4	-3.7
Health satisfaction	1.7	2.2	6.9	1.1	2.4	0.9	1.2	2.1	1.0	0.4	0.6	2.5	1.2	1.7	1.0	1.8	1.2	1.2	0.9	0.4	2.1	2.6	-0.3
Leg fat mass (right)	1.7	6.6	28.2	1.9	2.8	0.3	2.3	2.8	2.4	1.2	2.4	0.1	1.7	3.1	2.1	2.2	3.4	2.7	2.9	5.3	2.9	1.6	2.5
Mood swings	1.7	3.1	11.2	-2.1	-0.7	-2.3	-1.9	1.5	-2.2	-3.3	-1.5	-0.4	-2.0	-1.4	-2.0	-1.4	-1.8	-1.2	-0.7	-0.8	-0.3	-0.6	-3.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.7	-1.9	-0.1	-1.2	-1.8	1.1	-2.0	-1.8	-1.4	-0.2	-1.9	-1.2	-1.8	-0.5	-1.4	-1.5	-1.6	-0.7	-0.3	-0.3	-2.2
High cholesterol (Self-reported)	1.7	3.0	4.7	1.8	1.8	2.0	1.8	0.9	1.9	1.7	1.7	0.3	1.8	2.0	1.9	2.2	1.6	1.7	1.8	2.1	1.4	0.9	2.0
Alcohol drinker status: Previous	1.7	1.9	6.9	1.1	2.6	1.5	1.1	2.2	1.1	1.0	1.0	1.4	1.2	1.5	1.1	1.6	1.3	0.7	1.0	0.7	1.7	1.7	0.4
Leg fat mass (left)	1.7	6.7	27.4	2.0	2.6	0.4	2.4	2.5	2.5	1.2	2.4	0.1	1.8	3.1	2.2	2.3	3.5	2.8	3.0	5.2	2.9	1.6	2.7
Impedance of arm (right)	1.6	7.2	10.6	-2.7	-3.2	-2.0	-2.7	-2.8	-2.7	-2.3	-2.5	-2.6	-2.5	-2.9	-2.7	-3.0	-3.2	-1.9	-2.0	-2.8	-3.2	-2.4	-3.1
Medication: Ibuprofen	1.6	1.9	6.7	0.9	2.6	1.5	0.9	2.2	0.7	0.5	0.7	2.5	1.0	1.1	0.9	1.7	0.7	0.2	0.5	0.2	2.1	1.8	-0.3
Hand grip strength (right)	1.5	4.1	7.5	-2.7	-2.1	-1.7	-2.7	-0.2	-2.7	-2.2	-1.7	-1.4	-2.6	-2.5	-2.5	-1.5	-1.9	-1.8	-1.9	-2.1	-0.9	-1.7	-1.7
Vascular/heart problems diagnosed by doctor	1.5	4.1	12.4	2.0	1.1	2.7	1.9	1.3	1.5	2.2	2.0	3.5	2.3	1.7	2.1	2.4	1.3	1.5	1.5	-0.4	2.0	3.0	1.2
Age when periods started (menarche)	1.4	3.3	11.6	-1.3	-3.4	-2.0	-1.4	-2.6	-1.4	-1.6	-1.6	-1.1	-1.4	-1.7	-1.4	-2.3	-1.6	-0.8	-1.3	-1.2	-2.9	-1.8	-1.0
Hayfever, allergic rhinitis or eczema	1.4	3.0	5.2	1.8	1.1	1.8	1.9	0.8	1.7	2.0	2.2	0.0	1.8	2.0	2.0	1.4	2.3	2.1	1.9	1.6	1.3	1.1	2.2
Financial difficulties in last 2 years	1.4	1.9	4.6	-1.3	0.7	-2.0	-1.3	0.9	-1.5	-1.9	-1.9	-0.1	-1.4	-1.0	-1.5	-0.5	-1.4	-1.9	-2.0	-0.5	-0.5	-0.4	-2.2
Worrier / anxious feelings	1.4	2.7	7.5	-1.3	-2.7	-1.9	-1.4	-1.9	-1.4	-2.1	-1.5	-1.0	-1.5	-1.5	-1.5	-2.5	-1.7	-1.1	-1.0	-1.6	-1.4	-1.3	-1.4
Happiness	1.4	1.7	3.0	1.4	1.7	0.9	1.4	1.4	1.3	0.8	0.9	1.6	1.4	1.6	1.3	1.1	1.5	1.1	1.2	0.8	1.6	1.5	0.5
Body fat percentage	1.4	5.6	24.3	1.9	2.9	0.7	2.2	2.4	2.4	1.2	2.1	-0.0	1.7	2.9	2.0	2.2	2.9	2.4	2.8	4.9	2.4	1.5	1.8
Worry too long after embarrassment	1.4	2.3	7.7	-1.7	-1.1	-1.5	-1.7	0.1	-1.7	-1.9	-1.7	-0.3	-1.6	-1.5	-1.7	-1.2	-2.1	-1.7	-1.2	-1.4	-0.9	-0.6	-2.8
Medication: Seretide 50 evohaler	1.4	1.6	3.1	1.4	1.7	1.5	1.3	1.1	1.3	1.5	1.1	1.8	1.4	1.0	1.3	0.7	1.1	0.2	0.7	-0.7	1.6	1.0	1.3
Qualifications: nursing, teaching	1.4	2.2	6.1	1.3	1.9	2.0	1.2	1.8	1.3	1.3	1.2	2.2	1.5	1.2	1.3	1.9	1.2	0.2	0.7	-0.5	2.5	1.6	0.7
Cholesterol lowering medication	1.4	2.0	3.5	1.6	0.7	1.6	1.6	0.4	1.9	1.9	1.4	0.7	1.6	1.6	1.6	1.6	1.2	1.4	1.4	1.4	0.8	0.9	1.8
LDL Cholesterol	1.3	2.1	4.7	1.3	1.0	1.6	1.4	0.0	1.4	1.7	1.8	-0.4	1.4	1.4	1.6	1.6	2.0	1.8	1.4	1.4	1.3	0.6	2.2
Triglycerides	1.3	2.1	7.3	1.3	2.7	1.9	1.3	1.7	1.3	1.4	1.4	0.7	1.5	1.4	1.4	2.3	0.9	0.7	1.2	1.3	1.5	1.1	0.9
Blood White Count	1.3	10.0	14.4	2.7	3.6	3.3	2.9	3.8	2.9	3.4	3.7	0.7	2.8	3.5	3.0	3.8	3.6	2.9	3.2	3.6	2.8	2.1	3.5
Systolic blood pressure, automated reading	1.3	3.9	6.9	1.9	0.6	2.3	2.0	0.5	2.1	2.5	2.6	0.3	2.1	2.1	2.2	2.2	2.4	2.3	2.2	1.2	1.8	1.3	2.6
Qualifications: CSEs or equivalent	1.3	1.8	5.1	-0.5	-1.4	-1.7	-0.6	-1.6	-0.6	-1.4	-2.0	1.4	-0.9	-1.0	-0.9	-2.3	-1.2	-1.3	-1.7	-1.3	-1.6	-0.1	-1.1
Pulse wave peak to peak time	1.3	1.5	3.8	-0.9	-0.7	-0.8	-1.1	-1.0	-1.1	-1.3	-1.4	-0.1	-1.0	-1.4	-1.1	-1.6	-1.6	-1.7	-1.4	-1.9	-0.9	-1.0	-1.2
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	7.5	-0.9	-2.2	-0.8	-0.9	-2.7	-0.7	-0.7	-1.1	-1.1	-1.1	-1.3	-1.0	-2.1	-0.5	-0.3	-0.7	-0.6	-1.6	-1.7	0.0
Frequency of depressed mood in last 2 weeks	1.2	1.7	5.3	0.5	1.3	0.1	0.8	2.3	0.5	0.3	1.2	1.2	0.7	1.5	0.7	1.8	1.0	1.6	1.5	1.4	1.6	2.3	-0.6
Emphysema/chronic bronchitis	1.2	1.3	2.4	1.4	1.5	1.5	1.4	1.2	1.2	0.9	0.9	1.6	1.3	1.3	1.3	0.8	1.2	0.4	0.8	0.5	0.8	1.2	0.8
Number of full sisters	1.2	1.4	4.9	-0.8	-2.1	-1.2	-0.9	-1.8	-0.8	-0.9	-0.8	-0.9	-0.9	-1.1	-0.8	-1.7	-0.4	-0.3	-1.0	-2.2	-0.9	-1.4	0.2
Illnesses of siblings: Diabetes	1.2	1.4	4.4	0.8	1.7	-0.0	1.1	1.3	0.9	0.7	0.9	1.1	0.7	1.8	0.9	1.2	1.6	1.7	0.8	2.1	0.5	1.5	0.4
Miserableness	1.2	2.0	6.1	-1.8	0.4	-1.6	-1.6	2.4	-2.0	-2.4	-0.9	-0.2	-1.7	-1.0	-1.7	-0.1	-1.3	-1.0	-0.6	0.1	0.3	-0.1	-2.5
High blood pressure	1.1	3.2	10.7	-1.7	-1.2	-2.4	-1.6	-1.6	-1.1	-1.7	-1.8	-3.3	-2.0	-1.4	-1.8	-2.2	-1.0	-1.0	-1.2	0.8	-2.1	-2.7	-0.9
Length of working week for main job	1.1	1.2	6.5	0.8	2.5	1.6	0.7	0.8	0.7	1.5	0.1	1.8	0.8	0.6	0.7	1.7	-0.2	-0.4	-0.3	0.8	1.1	1.1	0.1
Medication for pain relief, constipation, heartburn	1.1	1.8	6.1	1.4	-1.2	1.2	1.3	-2.5	1.3	2.3	1.0	0.3	1.5	0.6	1.4	-0.0	1.2	1.3	0.7	-1.4	-0.3	0.3	2.4
Whole body fat mass	1.1	4.5	25.3	1.5	2.0	-0.1	1.8	2.0	2.0	0.8	1.9	-0.6	1.2	2.5	1.7	1.7	2.8	2.3	2.5	5.0	2.0	1.1	2.0
Hypertension (Self-reported)	1.1	3.0	11.0	-1.7	-1.5	-2.4	-1.5	-1.6	-1.0	-1.7	-1.6	-3.3	-2.0	-1.3	-1.7	-2.2	-0.7	-0.8	-1.0	0.8	-1.8	-2.6	-0.6
Smoking status: Previous	1.1	1.6	5.6	-1.0	-2.4	-1.4	-0.9	-2.3	-0.7	-0.9	-0.6	-2.1	-1.0	-1.1	-0.9	-1.5	-1.2	-0.0	-0.2	-0.5	-1.5	-1.3	-0.8
Medication for cholesterol	1.1	1.7	3.8	1.1	1.8	1.7	1.0	1.9	0.7	1.7	1.3	1.6	1.3	0.9	1.1	1.5	1.0	0.2	0.9	-0.6	1.7	1.6	0.4
Alcohol drinker status: Never	1.1	1.3	3.2	1.6	1.8	1.2	1.5	0.7	1.4	1.3	0.7	1.4	1.4	1.1	1.3	0.7	0.7	0.4	0.6	0.8	-0.2	0.8	1.1
Supplements: Calcium	1.1	1.3	3.2	-1.6	-0.5	-0.7	-1.5	0.8	-1.5	-1.3	-0.7	-1.0	-1.4	-1.1	-1.4	-0.5	-1.2	-0.9	-0.9	-0.3	-1.3	-0.6	-1.8
HDL Cholesterol	1.0	1.6	4.4	-1.2	-2.1	-1.4	-1.1	-2.1	-1.1	-1.0	-1.3	-0.6	-1.2	-1.1	-1.2	-1.7	-0.9	-0.1	-1.1	-1.1	-1.4	-0.6	-1.4
Average weekly spirits intake	1.0	1.2	3.3	0.9	1.1	1.2	0.9	1.2	0.9	1.6	1.5	-0.0	0.9	1.0	1.0	1.3	1.1	0.7	1.2	1.8	0.1	0.4	1.2
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	4.2	1.0	0.6	0.6	1.0	0.0	1.3	1.3	1.0	-0.3	0.9	0.9	1.0	0.5	1.2	1.0	1.0	1.9	0.2	-0.3	2.0
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	6.8	0.4	0.8	0.4	0.6	2.5	-0.0	-0.3	0.9	2.4	0.6	1.2	0.5	1.6	0.6	1.1	1.0	0.6	1.3	2.6	-1.1
Allergy	1.0	2.3	3.9	-1.7	-1.0	-1.7	-1.7	-0.3	-1.5	-2.0	-1.9	0.0	-1.8	-1.7	-1.9	-1.3	-1.9	-1.8	-1.5	-1.0	-0.8	-0.8	-1.9
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	3.0	1.0	1.4	1.5	0.9	1.6	0.7	1.2	1.1	0.7	1.2	1.0	1.1	1.7	0.8	0.3	0.7	-0.1	1.4	1.1	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.2	6.1	-1.1	-2.0	-1.2	-1.3	-1.9	-1.0	-0.9	-1.6	-0.6	-1.1	-1.8	-1.3	-1.8	-1.7	-1.7	-1.6	-2.5	-1.2	-1.5	-0.8
Diastolic blood pressure, automated reading	1.0	3.0	13.5	-1.7	-3.0	-2.2	-1.3	-3.1	-1.0	-0.9	-0.7	-3.7	-1.7	-0.8	-1.3	-1.2	0.0	1.1	-0.4	1.3	-1.7	-1.8	0.1
Reaction Time	0.9	1.7	5.0	1.4	-0.4	0.6	1.5	-0.8	1.5	1.2	1.1	0.9	1.4	1.6	1.4	0.6	1.6	2.2	1.4	1.4	0.5	1.3	1.6
Angina	0.9	1.1	3.5	-1.1	-1.2	-1.9	-0.8	1.5	-0.9	-1.6	0.3	-1.8	-1.1	-0.0	-0.8	-0.1	0.4	0.6	0.8	1.8	0.4	-0.4	-0.3
Trunk fat percentage	0.9	3.5	19.4	1.3	2.0	0.2	1.6	1.9	1.8	0.7	1.6	-0.6	1.2	2.3	1.5	1.5	2.2	2.0	2.4	4.4	1.7	0.9	1.2
Hearing difficulty/problems with background noise	0.9	1.5	2.7	-1.6	-0.5	-0.9	-1.6	-0.6	-1.4	-1.1	-1.1	-1.4	-1.4	-1.6	-1.5	-0.7	-1.5	-1.3	-1.0	-1.3	-0.1	-1.3	-1.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.8	0.5	0.1	1.0	0.7	1.2	0.6	1.0	1.7	-0.9	0.7	1.1	0.9	1.4	1.3	1.3	1.5	1.3	1.3	0.6	1.4
Time employed in main current job	0.9	1.0	3.7	-1.1	-0.4	-0.6	-1.1	-1.2	-1.1	-0.3	-0.6	-1.2	-1.0	-1.1	-0.9	-0.9	-0.7	-0.4	-1.4	-1.0	-1.9	-1.3	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	11.0	-0.4	0.8	-0.4	-0.2	3.3	-0.7	-1.6	0.3	1.9	-0.2	0.7	-0.3	1.1	0.3	0.4	0.3	-0.7	1.5	2.0	-1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.8	0.9	1.2	0.4	1.0	1.0	1.1	0.8	1.0	0.8	0.8	1.1	0.9	1.3	1.2	1.3	0.9	1.2	0.7	1.1	1.2
Medication: Aspirin	0.9	1.1	2.5	-1.2	0.0	-1.4	-1.2	1.0	-0.9	-1.5	-0.8	-1.6	-1.3	-0.9	-1.2	-0.3	-0.8	-1.2	-0.4	1.4	0.5	-1.3	-0.9
Medication: Gliclazide	0.9	1.0	5.0	0.2	0.4	0.2	0.5	2.2	0.2	-0.4	1.1	0.5	0.3	1.1	0.4	1.1	1.1	1.2	1.5	1.8	1.3	1.2	0.3
Myopia	0.9	1.3	7.5	-0.7	-1.6	-0.6	-0.7	-2.7	-0.2	-0.0	-0.7	-1.8	-0.6	-0.9	-0.7	-1.3	-1.3	-0.2	-0.6	-0.6	-1.7	-1.4	-0.8
Worry (Nagel 2018)	0.8	1.6	4.8	-1.3	-2.2	-1.5	-1.2	-1.2	-1.5	-1.9	-0.9	-1.2	-1.3	-1.2	-1.3	-1.7	-1.2	-0.4	-0.3	-0.9	-0.5	-0.6	-1.6
Ovarian Cancer	0.8	1.1	3.8	-1.3	0.3	-0.4	-1.3	0.3	-1.4	-0.8	-0.5	-1.9	-1.2	-1.0	-1.1	-0.0	-0.9	-1.0	-1.2	0.1	-1.3	-1.5	-0.4
Type 2 Diabetes (T2D) (2018)	0.8	1.6	3.6	1.1	1.4	0.5	1.1	1.5	1.3	0.8	1.2	0.5	0.9	1.3	1.1	0.8	1.9	1.0	1.4	1.7	1.7	0.7	1.6
Chronotype (morning person)	0.8	1.8	6.1	-0.6	-1.9	-1.4	-0.8	-2.5	-0.6	-0.5	-1.6	-0.4	-0.8	-1.4	-0.9	-2.1	-1.6	-1.5	-1.3	-1.4	-1.6	-1.2	-0.6
Fed-up feelings	0.8	1.5	5.7	-1.4	-0.1	-2.1	-1.1	1.3	-1.5	-2.4	-0.9	-0.1	-1.4	-0.6	-1.3	-0.7	-1.0	-0.2	-0.0	0.8	-0.1	0.2	-2.2
Falls in the last year	0.8	1.1	3.3	0.6	0.7	-0.0	0.8	1.1	0.8	0.4	1.3	-0.5	0.6	1.1	0.9	1.2	1.8	1.1	1.0	1.6	1.6	0.4	1.5
Mouth/teeth dental problems: Dentures	0.8	1.4	6.7	1.0	1.9	0.5	1.2	0.5	1.4	0.4	0.4	0.8	0.9	1.4	0.9	1.2	1.0	1.1	1.2	2.6	1.3	1.1	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	5.6	-0.2	2.3	0.7	-0.2	2.4	-0.4	-0.5	-0.2	1.5	-0.1	0.3	-0.2	1.2	-0.0	-0.5	-0.3	0.2	1.3	1.0	-1.2
Birth weight	0.8	1.6	3.8	-1.4	-1.9	-1.9	-1.3	-0.9	-1.3	-2.0	-1.2	-0.8	-1.4	-1.1	-1.4	-1.4	-1.1	-0.3	-0.8	-0.9	-1.2	-0.7	-1.3
Angina (self-reported)	0.8	1.1	4.2	-1.0	-1.2	-1.8	-0.6	1.6	-0.8	-1.6	0.4	-1.6	-1.0	0.2	-0.7	0.1	0.6	0.7	0.8	2.0	0.6	-0.2	-0.1
Medication: Aspirin	0.8	1.1	2.5	-1.2	0.1	-1.1	-1.2	1.1	-1.0	-1.5	-0.7	-1.6	-1.3	-0.8	-1.1	-0.3	-0.8	-1.2	-0.5	1.3	0.4	-1.3	-1.1
Eye problems/disorders: Glaucoma	0.8	1.0	3.8	-0.7	-0.7	-1.0	-0.7	-1.3	-0.5	-0.3	-1.1	-1.6	-0.8	-0.8	-0.8	-1.2	-0.9	-0.6	-0.6	0.1	-2.0	-1.3	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.5	-0.6	-0.6	-0.6	-0.8	-1.2	-0.8	-0.9	-1.4	-0.3	-0.7	-1.1	-0.8	-0.5	-1.5	-1.6	-1.5	-0.9	-1.2	-0.9	-0.9
Depressed Affect (Nagel 2018)	0.7	1.5	7.0	-1.4	-0.2	-1.7	-1.1	1.9	-1.7	-2.6	-0.5	0.1	-1.3	-0.4	-1.2	-0.4	-0.6	0.1	0.1	-0.3	0.7	0.7	-2.3
Schizophrenia vs Biploar Disorder	0.7	1.0	2.6	-0.8	-0.8	-1.6	-0.8	-0.6	-0.7	-1.5	-1.5	0.7	-0.9	-0.8	-1.0	-1.2	-0.8	-1.0	-1.0	-0.9	0.2	-0.2	-1.3
Crohns Disease (2017)	0.7	1.5	5.6	1.1	0.3	0.4	1.2	-1.0	1.5	1.7	1.4	-0.8	1.1	1.1	1.3	0.3	1.9	1.6	1.1	1.3	0.3	-0.3	2.4
Verbal and Numeric Reasoning (VNR)	0.7	1.6	6.7	-0.6	-1.6	-1.3	-0.7	-2.6	-0.5	-0.6	-0.9	-1.9	-0.7	-1.1	-0.6	-1.9	0.1	-0.7	-1.1	-1.4	-0.9	-2.1	0.9
Neuroticism	0.7	1.8	6.2	-1.6	-1.5	-2.1	-1.5	0.7	-1.8	-2.5	-0.7	-0.5	-1.5	-1.0	-1.5	-0.9	-1.2	-0.3	-0.2	-0.6	-0.0	-0.0	-2.2
Medication: Co-codamol	0.7	0.8	2.5	0.8	0.9	-0.3	1.0	0.8	0.8	-0.4	0.6	1.0	0.7	1.3	0.8	0.2	1.0	1.4	1.1	0.9	0.7	1.6	-0.3
Pack years adult smoking proportion	0.7	1.1	7.0	0.9	2.6	0.9	0.7	1.9	0.8	0.2	-0.1	1.3	0.7	0.6	0.6	0.6	0.4	-0.9	0.2	1.1	1.4	0.4	0.1
Multivitamins +/- minerals	0.7	0.9	2.4	-1.3	0.2	-0.4	-1.2	1.4	-1.3	-1.0	-0.7	0.3	-1.1	-0.9	-1.2	0.1	-1.0	-0.8	-0.9	-0.7	-0.0	-0.0	-1.5
Trunk fat mass	0.7	2.9	20.2	1.1	1.1	-0.6	1.4	1.3	1.6	0.4	1.5	-1.1	0.8	2.0	1.2	1.0	2.2	2.0	2.2	4.5	1.4	0.5	1.7
Nervous feelings	0.7	1.3	8.3	-0.4	-2.9	-0.9	-0.4	-2.6	-0.5	-0.3	-0.5	-1.2	-0.5	-0.7	-0.5	-1.8	-0.7	0.5	0.3	-0.6	-1.0	-0.5	-0.3
Fluid intelligence score	0.7	1.5	4.2	-1.0	-1.1	-1.1	-1.1	-2.1	-1.0	-1.1	-1.2	-1.5	-1.0	-1.2	-1.0	-1.6	-0.4	-0.7	-1.4	-1.7	-0.9	-1.8	-0.1
Neuroticism score	0.7	1.5	5.7	-1.3	-1.7	-2.3	-1.1	0.3	-1.4	-2.4	-0.7	-0.1	-1.3	-0.7	-1.2	-1.2	-0.9	0.1	0.0	-0.3	-0.2	0.2	-1.9
Weight	0.7	3.2	21.6	0.8	0.6	-1.1	1.2	1.2	1.3	0.5	1.7	-1.3	0.5	1.9	1.1	0.9	2.6	2.3	2.1	4.7	1.4	0.5	2.4
Depression (self-reported)	0.7	0.8	4.4	0.5	1.3	0.6	0.5	1.4	0.3	-0.4	0.0	2.1	0.6	0.5	0.4	0.6	-0.1	0.0	0.5	-0.4	1.3	1.6	-1.2
Ever highly irritable/argumentative for 2 days	0.7	0.8	3.9	0.0	0.8	-0.6	0.2	2.0	-0.1	-0.8	-0.0	1.4	-0.1	0.7	-0.0	0.6	0.0	0.6	0.8	1.4	0.9	1.6	-1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	5.8	-0.3	-2.0	-1.3	-0.2	-2.4	-0.3	-0.3	-0.1	-1.6	-0.4	-0.3	-0.2	-1.1	0.1	1.1	0.3	0.3	-0.9	-0.6	0.4
Gout (self-reported)	0.7	1.0	2.6	0.6	1.2	1.6	0.6	1.6	0.3	0.4	1.4	0.9	0.8	0.9	0.8	1.4	0.7	1.0	1.0	-0.1	1.2	1.4	0.4
Qualifications: College or University degree	0.7	2.1	10.2	0.7	1.2	1.9	0.6	2.7	0.7	0.8	1.9	0.0	1.0	1.0	1.0	2.4	1.2	0.6	1.6	0.7	3.2	1.0	0.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	5.0	-0.8	-1.6	-2.2	-0.7	0.4	-0.7	-1.9	-0.2	-0.9	-0.9	-0.3	-0.7	-1.3	0.5	0.4	0.4	0.6	0.3	-0.5	-0.6
Medication: Bendroflumethiazide	0.7	1.0	7.2	0.2	-0.5	-0.2	0.1	-2.7	0.5	0.3	-0.6	-1.6	-0.1	-0.4	0.0	-1.2	-0.2	-0.1	-0.3	0.6	-1.8	-1.7	0.7
Pack years of smoking	0.7	1.1	5.2	1.0	2.3	1.1	0.9	1.7	1.1	0.4	0.2	1.2	0.9	0.7	0.8	0.7	0.5	-0.6	0.6	1.3	1.4	0.5	0.3
Neuroticism (Nagel 2018)	0.6	1.5	6.0	-1.5	-1.0	-1.8	-1.3	0.8	-1.6	-2.4	-0.6	-0.3	-1.3	-0.6	-1.3	-0.7	-0.9	0.2	0.1	-0.4	0.2	0.3	-2.4
Type 2 Diabetes (T2D) (2012)	0.6	0.7	3.1	-0.4	0.4	-0.4	-0.3	-1.2	-0.0	0.6	-0.4	-1.8	-0.5	-0.4	-0.3	-0.2	0.1	0.4	-0.2	1.8	-0.8	-1.5	1.0
Allergy or Eczema	0.6	1.7	3.7	1.5	1.1	1.5	1.5	0.6	1.3	1.7	1.6	0.2	1.4	1.4	1.6	1.0	1.6	1.2	1.1	0.9	0.6	0.6	1.9
Hand grip strength (left)	0.6	1.5	3.4	-1.8	-1.7	-1.0	-1.7	0.1	-1.8	-1.1	-0.6	-1.0	-1.6	-1.5	-1.5	-0.6	-1.0	-0.9	-1.0	-1.2	-0.3	-0.9	-0.6
Townsend deprivation index at recruitment	0.6	0.9	6.4	-0.0	2.5	0.2	0.0	2.5	-0.0	-0.1	-0.1	0.9	-0.1	0.6	-0.0	1.2	0.4	-0.6	-0.7	0.9	0.1	0.5	-0.2
Taking other prescription medications	0.6	1.0	4.5	0.6	1.7	-0.0	0.7	2.1	0.7	-0.1	0.9	1.0	0.6	1.1	0.7	0.8	0.9	0.8	1.0	0.9	1.2	1.3	-0.3
Stomach or abdominal pain in last month	0.6	0.7	3.3	-0.9	-0.3	-1.0	-0.6	0.8	-0.7	-1.6	-0.1	-0.6	-0.8	0.1	-0.7	0.0	-0.2	1.0	0.6	1.8	-0.3	0.3	-1.3
Medication: Atenolol	0.6	0.8	2.3	1.2	0.1	0.0	1.3	-0.2	1.5	-0.1	0.5	0.1	1.0	1.1	1.1	-0.3	1.1	0.8	1.2	1.2	0.4	0.4	0.7
High blood pressure (mother)	0.6	0.9	2.2	-0.8	-0.7	-0.2	-0.8	-1.1	-0.8	-0.4	-0.9	-1.3	-0.7	-1.0	-0.8	-1.0	-1.0	-1.0	-1.0	-1.5	-0.9	-1.2	-0.6
Pulse wave reflection index	0.6	0.7	4.7	-0.3	-1.0	-0.8	-0.2	-2.2	0.1	0.1	-0.4	-1.4	-0.4	-0.3	-0.3	-1.0	-0.2	0.5	-0.1	1.2	-1.3	-1.1	0.4
Blood clot in the leg (DVT)	0.6	0.8	2.2	-0.5	-0.2	-0.4	-0.7	-0.8	-0.6	-0.7	-1.3	-0.1	-0.5	-1.0	-0.7	-0.4	-1.4	-1.5	-1.3	-0.9	-1.0	-0.6	-0.9
High blood pressure (siblings)	0.6	0.9	2.2	1.0	1.4	1.5	1.0	0.4	1.1	1.1	0.8	0.0	1.0	0.9	1.0	0.6	1.0	0.7	1.1	0.8	1.0	0.5	0.7
Neck or shoulder pain in last month	0.6	0.8	3.5	-1.0	0.1	-1.3	-0.8	1.7	-1.1	-1.9	-0.4	0.2	-0.9	-0.2	-0.9	0.2	-0.5	-0.4	-0.2	0.7	0.6	0.2	-1.5
Had major operations	0.6	0.7	4.2	-0.7	0.7	-1.2	-0.4	2.0	-0.5	-0.7	0.8	-1.2	-0.6	0.3	-0.4	0.5	1.0	0.7	0.8	1.3	0.6	0.2	-0.0
Eye problems/disorders: Cataract	0.6	0.7	1.9	0.7	-0.0	1.0	0.8	0.5	0.6	0.6	1.0	0.1	0.8	1.2	0.8	1.4	0.8	1.0	1.0	1.4	0.2	1.1	0.4
Wears glasses or contact lenses	0.6	0.7	2.9	-1.0	0.4	0.0	-0.9	1.1	-0.8	-0.6	-0.6	-1.3	-0.8	-0.5	-0.9	0.1	-0.9	-0.8	-0.4	0.5	-0.6	-1.0	-1.7
Ever taken oral contraceptive pill	0.6	0.7	2.6	0.5	1.0	0.1	0.6	1.2	0.3	-0.2	0.7	0.8	0.4	0.9	0.5	0.9	1.0	0.9	0.7	1.6	0.7	1.0	0.7
Medication: Blood pressure	0.6	1.2	5.1	-0.8	-1.1	-1.1	-0.7	-2.1	-0.3	-0.5	-0.7	-2.3	-1.0	-0.7	-0.7	-1.5	-0.3	0.1	-0.6	0.5	-1.5	-1.9	-0.1
Average weekly beer plus cider intake	0.6	0.9	2.2	-0.5	-0.7	-0.5	-0.7	-1.3	-0.7	-0.8	-1.1	-0.4	-0.6	-1.1	-0.7	-0.9	-1.0	-1.5	-1.3	-1.2	-0.8	-1.2	-0.2
Ever depressed for a whole week	0.6	0.7	2.4	0.6	0.9	0.4	0.8	1.0	0.8	0.5	0.7	0.3	0.7	1.0	0.7	0.7	0.8	1.2	1.4	1.6	0.5	0.9	-0.1
Crohns Disease (2012)	0.5	0.7	2.2	0.9	0.2	0.5	0.9	-0.2	1.0	1.4	1.1	-0.5	0.9	0.7	1.0	0.6	0.8	1.0	1.1	0.5	0.5	0.0	1.5
Vitamin and mineral supplements	0.5	0.7	2.1	1.0	0.1	0.5	1.0	-1.5	1.1	0.9	0.3	-0.8	0.8	0.7	0.9	-0.5	0.9	0.5	0.6	0.9	-0.1	-0.4	1.3
Medication: Metformin	0.5	0.6	3.4	-0.2	0.3	-0.6	0.0	1.9	0.0	-0.4	0.8	-0.5	-0.2	0.7	0.0	0.4	1.3	0.9	1.0	1.5	1.0	0.2	0.4
Maternal smoking around birth	0.5	0.7	1.8	1.3	0.8	-0.7	1.1	-1.2	1.2	-0.3	-0.5	1.4	1.0	0.5	0.8	-0.9	0.4	-0.3	0.2	-0.7	0.6	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.3	0.6	0.2	-0.3	0.8	0.9	0.8	0.3	0.5	1.3	0.6	1.0	0.6	0.5	0.3	1.1	1.2	0.8	0.6	1.5	-0.6
Diabetes (self-reported)	0.5	0.7	3.6	0.2	-0.6	-1.0	0.4	0.6	0.6	-0.1	0.8	-0.6	0.1	0.6	0.3	-0.1	1.4	1.0	1.3	1.9	0.8	-0.1	1.5
Pulse wave Arterial Stiffness index	0.5	0.6	2.6	0.3	0.0	0.3	0.5	0.5	0.5	0.8	1.0	-0.3	0.4	0.8	0.5	1.0	1.0	1.3	0.9	1.6	0.3	0.5	0.8
Birth weight of first child	0.5	0.8	2.4	0.7	0.9	0.8	0.8	1.4	0.7	-0.2	0.8	0.9	0.7	0.9	0.8	1.1	1.1	0.4	0.7	1.0	1.6	1.0	0.8
Medication: Paracetamol	0.5	0.8	3.9	-1.0	-0.6	-1.3	-0.8	0.9	-0.9	-1.8	-0.6	-0.1	-1.0	-0.4	-0.9	-0.4	-0.9	-0.4	0.0	0.5	-0.0	0.3	-2.0
Medication: Omeprazole	0.5	0.6	3.7	0.4	1.9	0.3	0.5	1.9	0.6	0.1	0.3	0.3	0.3	0.8	0.4	0.5	0.6	-0.1	0.4	1.6	0.4	0.3	-0.1
Comparative height size at age 10	0.5	3.0	13.8	-1.6	-3.7	-3.0	-1.3	-2.4	-1.3	-1.4	-0.6	-2.7	-1.6	-1.1	-1.3	-1.7	-0.8	0.7	0.1	1.0	-1.7	-1.2	-0.3
Suffer from ‘nerves’	0.5	0.8	2.2	-0.8	-1.5	-1.2	-0.7	-1.0	-0.8	-1.1	-0.8	-1.1	-0.9	-0.5	-0.8	-1.4	-0.5	0.1	-0.1	0.3	-0.8	-0.5	-1.2
Family relationship satisfaction	0.5	0.6	3.4	-0.7	1.1	-0.5	-0.6	1.8	-0.6	-0.9	-0.5	-0.3	-0.7	0.1	-0.7	0.7	-0.1	-0.0	0.0	1.4	0.5	0.2	-1.2
Back pain experienced in last month	0.5	0.7	3.1	0.3	-0.2	-0.6	0.3	1.8	0.1	-0.4	0.7	1.5	0.2	0.7	0.3	0.3	0.5	0.5	1.1	0.9	1.5	1.4	-0.4
Mineral and other dietary supplements	0.5	0.7	3.5	-0.6	-0.8	-0.8	-0.5	-1.6	-0.4	-0.1	-0.3	-1.9	-0.7	-0.6	-0.5	-1.3	-0.1	0.0	-0.2	0.0	-0.8	-1.4	0.3
Osteoporosis (self-reported)	0.5	0.6	3.5	-0.3	-1.9	-0.4	-0.3	-1.4	-0.0	-0.7	-0.2	-1.0	-0.3	-0.5	-0.3	-1.0	-0.4	0.1	-0.0	-0.4	-1.2	-0.9	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	4.7	-0.4	-2.2	-0.7	-0.4	-1.9	-0.3	-0.1	-0.4	-1.1	-0.5	-0.5	-0.4	-0.6	-0.1	0.2	-0.1	0.3	-0.7	-0.7	0.4
Guilty feelings	0.5	0.7	4.0	-0.2	-0.2	-0.8	-0.2	0.2	-0.4	-1.2	-0.9	2.0	-0.2	-0.2	-0.4	-0.6	-0.8	-0.2	-0.5	-1.2	-0.2	1.1	-1.8
Mother’s age at death	0.5	0.6	1.9	-0.7	-1.1	-0.8	-0.6	-0.9	-0.4	-0.6	-0.4	-1.4	-0.7	-0.8	-0.7	-1.1	-1.0	-0.2	0.2	-0.1	-0.9	-0.7	-0.3
Pain experienced in last month	0.5	0.8	2.9	0.2	-0.2	1.4	-0.0	-1.7	0.3	0.8	-0.6	-1.0	0.2	-0.8	0.0	-0.6	-0.6	-1.1	-1.0	-1.5	-1.1	-1.5	0.6
Basal cell carcinoma (self-reported)	0.5	0.6	2.6	-0.7	0.1	-0.3	-0.8	-0.0	-0.6	-0.1	-0.2	-1.3	-0.6	-0.9	-0.6	-0.5	-0.6	-1.1	-1.0	-1.6	-0.6	-1.2	-0.1
Depression (Nagel 2018)	0.4	0.6	2.4	0.0	0.7	-0.6	0.2	1.4	-0.1	-0.7	0.3	1.0	0.1	0.7	0.1	0.8	0.3	0.6	0.6	0.5	1.0	1.6	-1.0
Breast Cancer	0.4	1.1	2.0	-1.0	-1.0	-1.1	-1.0	-1.2	-1.1	-1.2	-1.3	-0.4	-1.1	-1.0	-1.1	-1.1	-0.8	-0.6	-1.4	-0.8	-1.3	-0.7	-0.7
Neuroticism (2016)	0.4	0.6	3.3	-0.0	-1.0	-1.1	0.3	0.0	0.0	-1.1	0.5	-0.1	-0.0	0.6	0.1	-0.3	0.5	1.8	1.3	1.5	-0.4	0.7	-0.4
Heel T-Score	0.4	3.4	10.8	1.3	2.4	3.3	1.1	2.6	0.5	2.4	1.9	1.7	1.7	1.3	1.5	2.6	0.8	-0.4	0.9	-1.2	2.9	1.8	0.6
Cardiovascular Disease	0.4	1.3	9.7	-1.0	0.9	-0.9	-0.9	-0.2	-0.4	-0.8	-0.9	-3.1	-1.2	-0.5	-0.9	-0.8	0.0	-0.6	-0.5	1.7	-0.3	-2.2	-0.0
Sensitivity / hurt feelings	0.4	0.7	3.3	0.3	-1.8	-1.2	0.5	-1.4	0.5	-0.3	0.4	-0.8	0.2	0.3	0.4	-1.2	0.7	1.2	1.1	0.3	0.2	-0.0	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.5	-0.7	-0.9	-0.8	-0.6	-0.2	-0.5	-0.9	-0.2	-0.7	-0.8	-0.3	-0.7	-0.6	-0.2	0.8	0.1	1.2	-1.1	-0.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.2	-0.4	0.8	-0.6	-0.2	1.5	-0.5	-1.2	-0.0	0.2	-0.3	0.4	-0.3	0.7	-0.2	0.4	0.3	1.0	0.3	0.9	-1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	3.1	0.8	0.9	1.8	0.7	1.0	0.5	1.5	1.2	0.0	0.9	0.7	0.9	1.5	0.8	0.1	0.6	0.1	1.4	0.3	1.2
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	2.2	0.1	0.6	0.1	-0.1	0.7	-0.3	0.2	-0.6	0.7	0.1	-0.4	-0.1	-0.5	-0.8	-1.5	-0.7	-1.4	-0.1	-0.3	-0.9
Hair/balding pattern: Pattern 2	0.4	0.5	2.4	-0.4	-0.7	0.2	-0.6	0.1	-0.5	-0.2	-0.5	0.9	-0.3	-0.9	-0.5	-0.6	-1.0	-1.1	-0.7	-1.5	-0.2	-0.3	-0.6
Pain all over the body in last month	0.4	0.4	1.4	-0.5	-0.4	-1.1	-0.4	-0.3	-0.6	-1.1	-0.7	0.4	-0.5	-0.2	-0.5	-0.0	-0.8	-0.0	-0.4	-0.2	-0.5	0.6	-1.2
Medication: Ramipril	0.4	0.5	3.5	0.2	1.2	-0.0	0.3	1.0	0.5	0.3	0.4	-1.2	0.1	0.4	0.2	0.1	0.0	-0.3	0.7	1.9	-0.3	-0.8	0.4
Alcohol intake versus 10 years previously	0.4	0.6	1.8	-0.7	1.1	-0.1	-0.7	1.4	-0.8	-0.6	-0.8	-0.5	-0.5	-0.4	-0.7	0.4	-0.6	-1.1	-1.0	-0.8	-0.1	-0.5	-1.2
Noisy workplace	0.4	0.5	1.4	0.9	1.2	0.9	0.8	0.7	0.8	0.7	0.4	1.1	1.0	0.5	0.7	0.5	0.1	-0.2	0.6	-0.7	0.8	0.7	-0.3
Prospective memory result	0.4	0.5	1.9	-0.7	-1.4	-1.0	-0.8	-0.2	-0.7	-0.5	-0.3	-0.7	-0.8	-0.9	-0.7	-0.9	-1.0	-0.5	-0.1	-0.6	-0.5	-0.7	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.0	0.3	0.6	0.3	0.4	1.2	0.4	0.0	0.6	1.3	0.4	0.6	0.4	0.8	0.2	0.8	0.9	0.9	1.0	1.4	-0.5
Medication: Blood pressure	0.4	0.6	3.9	-0.7	-0.2	-0.7	-0.6	-0.2	-0.4	-1.3	-0.7	-2.0	-0.7	-0.5	-0.7	-0.6	-0.4	-0.3	-0.0	0.8	-0.6	-1.4	-0.7
Mean time to correctly identify matches	0.4	0.9	3.0	1.1	-0.9	0.4	1.1	-1.7	1.2	0.9	0.4	0.4	1.1	0.8	1.0	0.0	0.6	1.5	1.0	0.8	-0.3	0.6	0.8
Overall health rating	0.4	0.9	2.5	0.5	0.7	-0.5	0.7	1.5	0.6	-0.7	0.5	1.1	0.4	1.2	0.5	0.4	1.1	1.1	1.2	1.0	1.2	1.6	-0.2
Commuting to job workplace: Car/motor vehicle	0.4	0.4	1.3	-0.4	0.2	-0.5	-0.6	-0.0	-0.6	-0.7	-0.8	0.2	-0.5	-0.8	-0.6	-0.7	-0.9	-1.1	-0.8	-1.1	-0.1	-0.6	-0.5
Number of self-reported non-cancer illnesses	0.4	0.8	2.7	0.2	1.0	0.2	0.4	1.6	0.4	0.1	1.2	-1.0	0.4	0.9	0.5	1.2	0.8	0.9	1.2	1.5	0.8	0.4	0.1
Financial situation satisfaction	0.4	0.4	1.1	-0.4	1.1	-0.8	-0.4	0.8	-0.7	-1.0	-0.9	0.7	-0.5	-0.3	-0.5	0.1	-0.4	-0.8	-0.9	-0.3	0.6	0.2	-0.7
Fractured/broken bones in last 5 years	0.4	0.5	1.7	-0.1	0.9	-0.0	0.1	1.0	0.2	-0.2	0.8	-0.5	0.0	0.7	0.2	0.7	1.1	1.3	0.8	1.3	0.7	0.2	0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	3.0	-0.1	1.5	-0.4	0.0	1.7	0.2	-0.4	-0.2	0.0	-0.3	0.4	-0.2	0.0	0.0	-0.2	0.1	1.5	-0.0	0.0	-0.7
Heart disease (siblings)	0.4	0.5	2.8	0.1	1.4	-0.1	0.2	0.7	0.4	0.4	0.6	-1.2	-0.0	0.4	0.2	0.1	0.7	0.4	0.5	1.7	-0.5	-0.4	0.6
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.3	-0.7	-1.1	-0.5	-0.8	-1.3	-0.6	-0.4	-0.4	-2.1	-0.6	-0.9	-0.6	-0.9	0.1	-1.0	-0.9	-1.1	-0.3	-2.0	0.6
Alzheimer’s Disease (including proxy)	0.3	0.5	1.8	-0.9	0.6	-0.4	-0.8	1.3	-0.9	-0.9	-0.5	-0.4	-0.8	-0.5	-0.8	-0.1	-0.4	-0.5	-0.3	-0.1	0.5	0.2	-1.2
Major Depression (MDD)	0.3	0.3	1.5	-0.4	-0.5	-0.6	-0.4	-1.2	-0.3	-0.4	-0.7	-0.1	-0.3	-0.4	-0.4	-0.3	-0.9	-0.2	-0.5	-0.7	-0.6	0.0	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	1.4	-0.7	-1.2	-0.8	-0.7	-0.6	-0.8	0.0	0.1	-1.0	-0.7	-0.7	-0.5	-0.4	-0.1	0.3	-0.4	-0.1	-0.5	-0.7	0.5
HbA1C	0.3	0.3	1.4	0.6	0.4	0.9	0.5	-0.0	0.6	0.8	0.6	-0.4	0.7	0.2	0.6	0.2	0.5	0.0	0.1	-0.5	-0.1	-0.3	1.2
Primary Biliary Cirrhosis	0.3	0.4	1.7	0.4	1.3	0.8	0.4	0.7	0.3	0.5	-0.1	1.3	0.4	0.5	0.3	0.6	0.3	0.0	-0.2	-0.2	0.6	0.9	-0.2
Rheumatoid Arthritis	0.3	0.4	1.6	0.4	0.8	0.5	0.4	1.3	0.3	0.7	0.8	0.3	0.4	0.6	0.4	0.5	0.8	0.4	0.8	0.4	0.8	0.8	0.4
Blood Eosinophil Count	0.3	2.0	16.6	0.2	4.1	1.1	0.1	3.5	-0.1	0.4	-0.2	-0.4	0.2	0.2	0.0	1.4	-0.5	-1.8	-0.4	1.6	0.1	-0.5	-0.6
Waist Hip Ratio (WHR)	0.3	1.5	5.7	-1.1	-2.4	-1.2	-1.1	-1.4	-0.7	-1.0	-0.6	-1.9	-1.0	-1.2	-1.0	-1.3	-1.3	-0.5	-0.5	-0.8	-1.3	-1.5	-0.5
Lung FVC	0.3	1.7	6.8	-0.8	-2.4	-1.8	-0.9	-2.6	-0.9	-1.3	-1.4	0.0	-0.9	-1.2	-1.0	-1.7	-1.2	-0.3	-0.8	-1.1	-0.9	-0.4	-1.0
Number of treatments/medications taken	0.3	0.6	3.2	-0.1	1.3	-0.2	0.0	1.8	0.2	-1.1	0.1	-0.1	-0.0	0.5	-0.0	0.8	0.1	0.1	0.5	1.5	0.9	0.3	-0.9
Ever had hysterectomy (womb removed)	0.3	0.3	4.0	-0.5	0.9	-0.1	-0.3	2.0	-0.5	-0.3	0.5	-0.3	-0.3	0.1	-0.2	0.4	0.3	0.2	0.3	0.3	0.4	0.2	-0.5
Supplements: Zinc	0.3	0.3	1.1	0.2	0.5	-0.0	0.3	0.8	0.2	0.2	0.8	-0.2	0.3	0.8	0.4	0.8	0.7	1.1	0.7	0.4	0.5	1.0	0.3
Diabetes (mother)	0.3	0.4	2.6	-0.6	0.9	-0.6	-0.5	1.6	-0.5	-0.6	-0.4	-0.0	-0.7	-0.2	-0.6	0.1	-0.2	-0.4	-0.1	0.8	0.4	0.3	-0.7
Average weekly fortified wine intake	0.3	0.4	1.5	0.5	-0.2	0.7	0.5	-1.2	0.6	1.2	0.4	-0.9	0.6	0.1	0.6	0.2	0.2	0.2	0.4	0.2	-0.2	-0.5	0.9
Medication: Levothyroxine sodium	0.3	0.5	1.9	0.4	-0.0	0.6	0.4	0.5	0.1	-0.1	0.8	0.8	0.5	0.5	0.5	0.4	0.4	0.7	0.9	-1.2	1.4	1.2	-0.4
Past tobacco smoking	0.3	0.6	3.9	0.5	2.0	1.1	0.2	1.5	0.1	0.6	-0.2	1.2	0.4	0.1	0.2	0.8	-0.1	-1.2	-0.5	-0.0	0.4	0.2	-0.2
Mouth/teeth dental problems	0.3	0.5	3.0	-0.2	0.5	0.8	-0.4	1.2	-0.4	0.3	-0.1	0.3	-0.2	-0.7	-0.3	-0.3	-0.3	-1.4	-0.8	-1.7	0.1	-0.7	0.0
Trunk fat-free mass	0.3	1.5	5.7	-1.0	-2.3	-2.4	-0.8	-0.6	-0.8	-0.9	0.0	-2.2	-1.2	-0.6	-0.7	-1.1	0.4	0.2	-0.0	1.4	-0.5	-1.4	1.5
Tense / ‘highly strung’	0.3	0.6	1.4	-0.8	-0.2	-1.2	-0.5	1.2	-0.9	-1.2	0.1	-0.2	-0.7	0.2	-0.6	0.4	-0.1	1.0	0.6	1.0	0.4	0.8	-1.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	2.9	-0.0	-0.1	0.4	-0.0	1.5	-0.2	0.0	0.8	0.4	0.1	0.3	0.2	0.8	0.7	0.3	0.3	-1.0	1.7	0.6	0.4
Headache pain in last month	0.3	0.5	2.5	-0.3	0.6	-0.2	-0.2	1.6	-0.3	-0.8	0.5	1.0	-0.2	0.5	-0.1	0.9	0.1	0.9	0.7	0.9	0.5	1.1	-0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	3.5	-0.1	-0.4	0.1	-0.3	-0.8	-0.4	0.4	-0.5	1.4	-0.1	-0.6	-0.2	-0.5	-0.7	-0.7	-0.9	-1.9	-0.2	0.4	-0.3
Glaucoma (self-reported)	0.3	0.3	1.3	-0.4	0.4	-0.5	-0.4	-0.4	-0.3	-0.2	-0.8	-0.5	-0.4	-0.4	-0.5	-0.8	-0.7	-0.4	-0.5	0.1	-1.1	-0.6	-1.1
Medication: Amlodipine	0.3	0.4	1.5	0.7	0.6	0.5	0.7	-0.6	1.0	0.6	0.2	-0.3	0.6	0.6	0.7	0.3	0.5	0.6	0.6	1.2	0.9	0.0	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	2.3	-0.1	1.5	-0.5	-0.0	0.8	-0.1	0.1	-0.3	0.8	0.0	0.3	-0.1	0.6	-0.1	0.0	-0.4	-0.3	0.1	0.7	-1.1
Exposure to tobacco smoke outside home	0.3	0.4	2.9	-0.1	-0.3	-1.7	-0.1	-0.1	-0.1	-1.1	-0.7	0.4	-0.5	-0.3	-0.3	-1.2	0.2	-0.6	-0.5	0.3	0.1	-0.2	0.2
Wheeze or whistling in the chest in last year	0.3	0.5	2.6	-0.4	-0.6	-1.6	-0.3	0.1	-0.2	-0.8	-0.2	-1.1	-0.7	0.0	-0.4	-0.8	0.5	0.2	0.0	1.3	-0.2	-0.7	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	2.4	-0.0	-1.5	0.4	-0.0	-0.5	0.1	0.8	0.7	-0.9	0.1	-0.1	0.2	0.3	-0.1	0.5	0.4	-0.4	-0.3	-0.3	0.8
Eye problems/disorders: None of the above	0.3	0.4	2.1	0.7	-0.2	-0.1	0.6	-0.7	0.7	0.6	0.6	0.9	0.6	0.2	0.7	-0.2	0.6	0.3	0.1	-0.7	0.6	0.1	1.4
Medication: Allopurinol	0.3	0.4	1.9	0.1	0.5	1.4	0.1	1.2	-0.1	0.1	1.0	0.5	0.3	0.3	0.3	0.9	0.2	0.5	0.5	-0.7	0.7	0.8	0.1
Supplements: Vitamin C	0.3	0.3	1.4	0.3	-1.2	-0.4	0.3	0.2	0.4	0.6	0.8	0.5	0.3	0.2	0.3	0.3	0.3	0.8	1.0	0.6	0.2	0.5	0.9
Loneliness, isolation	0.3	0.4	1.9	-0.4	-0.4	-1.2	-0.3	0.0	-0.4	-1.0	-0.4	0.4	-0.4	0.0	-0.4	0.2	-0.7	0.3	0.0	0.3	-0.1	0.9	-1.4
Diabetes diagnosed by doctor	0.3	0.5	2.7	0.1	0.3	-0.7	0.3	1.1	0.4	-0.3	0.5	-0.1	0.0	0.7	0.2	0.2	1.1	0.8	1.0	1.7	1.0	0.4	0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.7	-0.7	1.0	0.3	-0.5	1.0	-0.5	0.2	0.2	-0.5	-0.5	0.1	-0.4	0.3	0.5	1.0	0.6	0.8	1.3	0.3	-0.6
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.7	0.6	1.3	0.6	0.5	1.0	0.7	0.4	0.3	0.5	0.6	0.5	0.5	0.5	0.3	-0.1	0.4	0.6	1.1	0.3	-0.2
Commuting to job workplace: Public transport	0.3	0.4	2.1	-0.2	-0.4	0.4	-0.0	-1.4	0.0	0.5	0.3	-1.4	-0.0	0.2	0.1	0.2	0.4	1.3	0.5	1.0	-0.2	-0.3	-0.0
Medication: Paracetamol	0.3	0.5	2.5	-0.4	0.2	-0.5	-0.3	1.5	-0.4	-1.3	-0.1	1.0	-0.4	0.0	-0.4	0.0	-0.6	-0.4	0.4	0.2	0.9	0.9	-1.6
Illnesses of father: High blood pressure	0.3	0.3	1.4	-0.7	0.5	-0.1	-0.7	0.3	-0.6	0.7	0.1	-1.2	-0.5	-0.7	-0.5	-0.0	-0.5	-0.9	-0.4	-0.5	0.4	-0.8	-0.4
Ever smoked	0.3	0.6	3.9	-0.1	-2.0	-0.7	0.1	-1.8	0.3	0.1	0.4	-0.8	-0.1	0.2	0.1	-0.5	0.3	1.5	0.5	0.4	-0.5	0.1	0.6
Risk taking	0.3	0.5	1.6	-0.5	1.3	-0.7	-0.3	1.2	-0.2	-0.6	-0.2	0.6	-0.5	0.4	-0.4	0.6	0.2	0.8	0.2	1.0	0.4	1.1	-1.0
Age at First Birth	0.2	0.2	1.0	0.7	-0.1	0.6	0.5	0.2	0.5	0.0	0.3	1.0	0.8	0.3	0.6	0.7	0.0	-0.4	0.0	-0.7	0.3	0.5	0.4
Fasting Glucose	0.2	0.2	0.6	-0.1	0.2	-0.7	-0.2	0.5	-0.2	-0.6	-0.8	0.8	-0.3	-0.2	-0.3	-0.6	-0.0	-0.5	-0.4	-0.2	0.2	0.2	-0.3
Lupus	0.2	0.3	1.9	-0.1	0.4	-0.2	-0.1	1.3	-0.3	-0.2	0.2	1.0	-0.0	0.1	-0.1	0.4	0.1	0.1	0.4	-0.6	1.4	0.8	-0.4
Blood Red Count	0.2	1.6	11.9	-0.8	-1.6	0.3	-0.8	-1.8	-0.5	1.1	0.2	-3.5	-0.5	-0.8	-0.5	0.0	-0.5	-0.4	-0.5	0.5	-2.1	-2.4	0.7
Lung FEV1/FVC ratio	0.2	1.1	4.4	1.1	1.0	0.9	1.1	-0.6	1.8	1.4	0.5	0.2	0.9	1.0	1.0	0.7	0.6	0.8	1.0	2.1	0.9	0.3	1.1
Hearing difficulty/problems: Yes	0.2	0.3	1.1	0.6	1.1	1.0	0.4	-0.3	0.6	0.7	-0.0	0.3	0.6	-0.1	0.5	0.1	0.1	-0.7	-0.2	-0.8	0.7	-0.3	0.6
Leg fat-free mass (left)	0.2	1.2	6.1	-0.0	-1.0	-2.0	0.2	0.3	0.3	-0.3	0.8	-1.8	-0.4	0.6	0.2	-0.4	1.5	1.2	1.0	2.5	0.3	-0.5	2.0
Relative age voice broke	0.2	0.2	0.7	0.3	0.3	0.8	0.3	0.2	0.2	0.8	0.7	0.1	0.5	0.2	0.4	0.8	-0.1	0.5	0.7	0.7	0.2	0.5	-0.0
Leg predicted mass (left)	0.2	1.2	6.0	-0.1	-1.1	-2.0	0.2	0.2	0.3	-0.3	0.8	-1.8	-0.4	0.5	0.2	-0.4	1.5	1.1	0.9	2.5	0.3	-0.5	1.9
Number of incorrect matches in round	0.2	0.4	2.5	0.3	0.0	0.4	0.1	-0.8	0.1	0.5	-0.7	1.5	0.3	-0.1	0.0	-0.0	-0.6	-0.4	-0.6	-1.6	-0.1	0.6	-0.7
Alcohol usually taken with meals	0.2	0.3	1.2	0.1	-0.0	0.9	0.1	0.0	0.2	1.1	0.8	-0.8	0.3	-0.0	0.3	0.4	-0.1	0.4	1.0	-0.5	1.1	-0.1	0.2
Had other major operations	0.2	0.3	0.9	-0.8	-0.0	-0.8	-0.7	0.6	-0.6	-0.7	-0.1	-0.9	-0.6	-0.3	-0.6	0.2	-0.5	-0.1	-0.1	0.1	-0.0	-0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	2.1	0.4	0.9	1.5	0.3	0.6	-0.0	0.9	0.8	0.1	0.6	0.3	0.5	1.2	0.4	-0.1	0.2	-0.6	1.0	0.2	0.7
Qualifications: None of the above	0.2	0.4	2.0	0.8	0.7	-0.2	0.9	-0.0	0.9	0.3	0.0	0.7	0.6	0.8	0.6	-0.2	0.4	0.8	0.8	1.4	-0.3	0.4	0.1
Heart attack	0.2	0.2	0.7	0.7	0.1	-0.5	0.6	-0.7	0.8	0.0	-0.1	-0.1	0.5	0.4	0.5	-0.7	0.6	0.1	0.5	0.4	0.3	0.1	0.2
Pulse rate	0.2	0.4	2.9	-0.5	0.1	-0.6	-0.3	1.5	-0.4	-0.7	0.1	-0.6	-0.5	0.2	-0.4	0.7	0.2	0.1	0.1	1.7	0.3	0.0	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.8	-0.1	-0.3	0.8	-0.2	1.0	-0.2	0.3	1.0	-0.4	0.1	0.1	0.2	1.1	0.5	0.2	0.2	-0.6	1.4	-0.1	0.7
Lung cancer (father)	0.2	0.2	1.3	0.4	-0.3	0.2	0.4	-0.6	0.3	-0.1	-0.3	1.1	0.3	0.2	0.2	-0.3	-0.0	0.2	0.2	-0.9	0.5	0.7	-0.1
Trunk predicted mass	0.2	1.4	5.4	-0.9	-2.2	-2.3	-0.7	-0.7	-0.7	-0.8	0.1	-2.2	-1.1	-0.5	-0.6	-1.1	0.5	0.3	0.0	1.5	-0.5	-1.3	1.6
Exposure to tobacco smoke at home	0.2	0.2	1.1	-0.2	0.7	-0.4	-0.2	0.9	-0.3	-0.2	-0.5	1.1	-0.4	-0.2	-0.4	-0.3	-0.1	-0.4	-0.6	-0.3	-0.4	0.4	-0.3
Hair/balding pattern: Pattern 4	0.2	0.4	1.2	0.4	-0.7	-1.1	0.3	-1.0	0.5	-0.6	-0.7	0.8	0.0	-0.0	0.1	-1.1	0.2	-0.2	-0.4	-0.8	-0.0	0.2	0.7
Arm fat-free mass (right)	0.2	1.2	5.7	-1.1	-1.4	-2.4	-0.8	-0.0	-0.9	-1.3	-0.3	-1.8	-1.4	-0.5	-0.9	-1.0	0.2	-0.0	-0.3	1.7	-0.5	-1.2	0.8
Comparative body size at age 10	0.2	0.6	2.0	1.1	1.1	0.4	1.0	-0.7	1.4	0.8	0.1	0.2	0.9	0.6	0.9	-0.1	0.9	-0.1	0.5	0.7	0.9	-0.1	1.1
Age at first live birth	0.2	0.4	1.4	0.2	-1.1	0.8	0.1	-0.4	-0.2	0.2	0.8	0.4	0.4	0.1	0.4	0.8	0.3	0.6	0.2	-1.2	0.7	0.6	1.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.7	-0.5	0.2	-0.8	-0.5	0.1	-0.6	-0.5	-0.4	0.1	-0.5	-0.3	-0.5	0.0	-0.6	-0.2	-0.1	0.3	-0.1	0.2	-0.8
Migraine (self-reported)	0.2	0.3	2.7	0.1	0.5	-0.1	0.2	0.4	0.2	-0.2	-0.3	1.6	0.1	0.4	0.0	0.6	-0.0	0.6	0.0	0.2	0.5	1.0	-0.8
Heart disease (mother)	0.2	0.3	0.7	0.7	-0.1	-0.2	0.7	-0.7	0.7	0.5	0.3	-0.2	0.5	0.6	0.6	-0.5	0.8	0.7	0.5	0.4	-0.2	0.0	0.8
Arm predicted mass (right)	0.2	1.2	5.8	-1.0	-1.5	-2.4	-0.7	-0.2	-0.7	-1.1	-0.2	-1.8	-1.3	-0.4	-0.8	-0.8	0.4	0.3	-0.1	2.0	-0.5	-1.1	1.0
Pulse rate, automated reading	0.2	0.5	2.9	-0.4	0.8	0.5	-0.2	1.7	-0.3	-0.7	0.2	-0.2	-0.2	0.4	-0.2	1.0	0.3	0.3	0.5	1.5	0.9	0.3	-0.8
Chest pain or discomfort	0.2	0.3	1.9	-0.2	-0.9	-1.4	-0.0	0.7	-0.1	-0.7	0.4	-0.1	-0.2	0.3	-0.1	0.1	0.1	0.6	0.7	0.6	0.4	0.5	-0.1
Age at last live birth	0.2	0.3	1.4	-0.5	-0.9	-0.1	-0.4	-0.1	-0.6	-0.2	0.5	-1.2	-0.4	-0.2	-0.2	0.9	-0.1	0.1	-0.2	0.6	-0.3	-0.5	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	2.8	-0.1	-0.5	0.0	-0.2	-0.6	-0.2	-0.2	-0.4	0.4	-0.0	-0.4	-0.2	-0.3	-0.4	-0.2	-0.3	-1.7	0.1	0.2	-0.4
Illnesses of father: Heart disease	0.2	0.2	1.0	0.1	1.0	-0.3	0.1	1.0	0.1	-0.5	0.1	0.8	0.1	0.3	0.1	0.2	0.3	0.2	0.1	0.3	0.7	0.7	-0.2
Whole body fat-free mass	0.2	1.4	5.8	-0.8	-2.0	-2.4	-0.5	-0.4	-0.5	-0.9	0.2	-2.2	-1.1	-0.3	-0.5	-0.9	0.8	0.5	0.3	1.8	-0.3	-1.1	1.6
Leg fat-free mass (right)	0.2	1.2	5.0	-0.0	-1.4	-1.9	0.2	-0.1	0.3	-0.2	0.8	-1.7	-0.3	0.6	0.2	-0.3	1.5	1.3	0.9	2.2	0.2	-0.4	2.1
Friendships satisfaction	0.2	0.2	1.0	-0.3	0.2	-0.1	-0.1	0.4	-0.3	-0.2	-0.3	0.7	-0.3	0.2	-0.3	0.6	-0.0	0.7	0.0	0.6	0.2	1.0	-0.7
Commuting to job workplace: Walk	0.2	0.2	0.9	-0.4	-0.4	0.1	-0.5	0.2	-0.4	-0.2	-0.2	-0.1	-0.3	-0.5	-0.4	0.0	-0.4	-0.7	-0.4	-1.0	-0.1	-0.3	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	1.5	-0.4	-0.4	-0.6	-0.3	-0.8	-0.4	-0.5	-0.2	-0.9	-0.4	-0.3	-0.3	-0.3	-0.4	0.2	-0.2	0.7	-1.2	-0.4	-0.3
Breast cancer (self-reported)	0.2	0.3	1.8	-0.1	0.2	-0.5	-0.2	-0.1	-0.3	-0.5	-0.6	0.6	-0.2	-0.3	-0.3	-0.5	-0.7	-0.6	-0.6	-0.2	-1.3	-0.3	-0.5
Whole body water mass	0.2	1.3	5.5	-0.6	-1.9	-2.3	-0.4	-0.3	-0.3	-0.8	0.3	-2.1	-0.9	-0.1	-0.4	-0.8	0.9	0.6	0.4	2.0	-0.2	-1.0	1.7
Leg predicted mass (right)	0.2	1.2	4.8	-0.1	-1.4	-2.0	0.2	-0.1	0.3	-0.3	0.8	-1.8	-0.4	0.5	0.2	-0.4	1.5	1.2	0.8	2.2	0.2	-0.5	2.0
Supplements: Fish oil (including cod liver oil)	0.2	0.3	2.7	-0.0	0.2	0.1	-0.1	1.6	-0.3	-0.4	0.1	1.0	0.1	-0.1	-0.1	0.8	-0.5	-0.7	-0.1	-0.2	0.3	0.5	-0.4
Basal metabolic rate	0.2	1.3	7.6	-0.2	-1.1	-2.0	0.1	0.2	0.1	-0.4	0.7	-1.9	-0.5	0.4	0.0	-0.3	1.4	1.1	0.8	2.8	0.2	-0.6	1.9
Arm fat-free mass (left)	0.2	1.1	6.9	-0.6	-1.1	-2.2	-0.3	0.1	-0.3	-0.9	0.1	-1.8	-0.9	0.1	-0.4	-0.5	0.7	0.4	0.2	2.6	-0.1	-0.8	1.3
Number of operations (self-reported)	0.2	0.4	1.1	-0.8	-0.1	-1.0	-0.6	1.0	-0.6	-0.8	0.4	-0.9	-0.5	0.0	-0.5	0.6	0.1	0.6	0.2	0.2	-0.1	0.2	-0.8
Arm predicted mass (left)	0.2	1.1	6.3	-0.6	-1.2	-2.1	-0.3	0.3	-0.3	-0.8	0.3	-1.8	-0.9	0.1	-0.4	-0.4	0.9	0.6	0.4	2.5	0.1	-0.8	1.4
Alzheimer’s Disease (in mother)	0.1	0.2	0.6	-0.4	0.8	-0.4	-0.3	0.7	-0.4	-0.4	-0.4	-0.4	-0.4	-0.2	-0.4	0.1	-0.1	-0.4	-0.3	0.4	0.1	0.2	-0.4
Alzheimer’s Disease (in father)	0.1	0.2	1.0	-0.3	-0.5	0.3	-0.3	-0.0	-0.3	-0.2	-0.2	0.0	-0.2	-0.5	-0.3	-0.3	-0.4	-0.3	0.0	-1.0	0.3	0.0	-0.7
Prostate Cancer	0.1	0.1	0.7	0.2	-0.8	-0.1	0.2	0.2	0.2	0.3	0.5	-0.6	0.2	0.2	0.2	-0.4	0.4	-0.2	0.5	-0.4	0.3	-0.2	0.5
Blood Platelet Count	0.1	1.2	6.4	-0.4	-1.0	0.3	-0.0	-1.0	0.2	0.8	1.4	-1.8	-0.2	0.5	0.2	0.8	1.1	2.5	1.3	2.0	-0.2	-0.1	1.2
Systolic Blood Pressure	0.1	0.6	2.4	0.4	0.1	1.1	0.4	0.1	0.5	0.8	1.1	-1.2	0.5	0.4	0.6	0.8	0.9	0.7	0.7	0.0	0.9	-0.6	1.5
Hypothyroidism (self reported)	0.1	0.3	1.4	-0.5	-0.4	0.1	-0.5	0.2	-0.7	-0.9	0.5	-1.2	-0.3	-0.3	-0.3	-0.0	0.1	0.1	0.4	-1.0	0.9	-0.1	-0.6
Tanning	0.1	0.8	3.9	1.2	-0.9	0.3	1.2	-2.0	1.4	0.4	0.3	1.0	1.0	0.7	1.0	-0.8	0.4	0.9	0.7	-0.3	-0.3	0.6	0.9
Relative age of first facial hair	0.1	0.3	1.5	0.2	0.6	1.2	0.2	0.2	0.0	0.5	0.6	-0.4	0.4	0.3	0.3	1.0	-0.2	0.1	0.6	0.5	0.6	0.4	-0.1
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.9	0.1	-1.0	-0.2	0.1	-0.1	0.2	0.1	0.2	0.2	0.0	0.1	0.1	0.1	-0.5	0.1	0.4	0.4	-0.2	0.3	0.1
Had menopause	0.1	0.2	1.0	0.0	-0.7	0.2	0.1	-1.0	0.2	0.1	0.1	-0.8	0.1	0.1	0.1	-0.3	-0.1	0.5	0.3	0.3	-0.8	-0.2	0.2
Illnesses of siblings	0.1	0.2	0.7	-0.2	-0.6	0.1	-0.3	-0.4	-0.4	-0.3	-0.4	0.7	-0.2	-0.5	-0.3	0.0	-0.6	-0.4	-0.5	-0.8	0.1	0.1	-0.2
Hair/balding pattern: Pattern 3	0.1	0.2	1.6	-0.1	-0.0	-0.5	-0.0	-0.1	0.0	0.3	0.4	-1.3	-0.0	0.2	0.0	0.1	0.2	0.8	0.7	0.8	0.1	-0.2	-0.1
Number of live births	0.1	0.1	0.7	0.0	0.7	0.3	-0.0	0.6	0.0	-0.2	-0.1	0.1	0.1	-0.1	-0.0	0.2	-0.1	-0.9	-0.4	-0.6	0.3	-0.1	0.2
Asthma	0.1	0.2	0.5	0.4	0.0	0.0	0.4	-0.6	0.3	0.5	0.5	-0.2	0.4	0.5	0.5	0.2	0.4	0.6	0.1	0.5	-0.7	-0.1	0.5
Breastfed as a baby	0.1	0.2	0.9	0.2	0.1	0.7	0.1	0.8	-0.0	0.2	0.5	0.3	0.4	0.1	0.3	0.9	0.3	-0.1	0.2	0.1	0.6	0.2	0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.9	-0.0	-0.1	0.1	0.0	0.5	-0.3	-0.3	0.9	-0.4	0.2	0.2	0.2	0.3	0.5	0.5	0.9	-0.9	1.4	0.6	-0.2
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.5	0.3	0.4	0.7	0.3	0.2	0.2	0.3	0.4	0.0	0.4	0.3	0.4	0.1	0.1	-0.0	0.0	-0.3	-0.1	-0.1	0.2
Number of full brothers	0.1	0.1	0.7	0.3	0.4	-0.0	0.3	0.2	0.2	0.0	-0.1	0.8	0.2	0.4	0.2	-0.1	0.4	0.5	-0.2	0.1	-0.5	0.5	-0.3
Asthma (self-reported)	0.1	0.2	0.8	0.2	-0.3	-0.3	0.3	-0.8	0.2	0.3	0.3	-0.3	0.2	0.4	0.3	-0.0	0.3	0.6	0.1	0.7	-0.9	-0.1	0.4
Medication: Lisinopril	0.1	0.2	0.8	-0.1	0.9	0.1	-0.1	0.4	-0.1	-0.1	-0.1	-0.5	-0.1	-0.1	-0.2	0.1	-0.4	-0.4	-0.1	0.7	-0.9	-0.4	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.5	0.4	-0.5	-0.4	0.4	-0.1	0.3	-0.2	0.0	0.2	0.3	0.1	0.3	-0.5	0.6	-0.1	-0.0	-0.3	-0.0	-0.2	0.7
Commuting to job workplace: Cycle	0.1	0.2	1.3	-0.5	-0.4	0.5	-0.4	-0.4	-0.5	0.2	-0.0	-1.1	-0.3	-0.1	-0.3	0.3	0.1	0.1	-0.3	-0.2	-0.2	-0.4	0.0
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.7	0.3	0.0	-0.7	0.3	-0.7	0.5	-0.2	-0.3	-0.3	0.2	0.1	0.2	-0.8	0.3	-0.2	0.2	0.2	0.2	-0.1	-0.1
Respiratory disease	0.0	0.1	0.4	0.1	-0.0	-0.0	0.1	-0.4	-0.1	0.4	-0.1	-0.1	0.1	-0.1	0.1	-0.1	-0.2	-0.7	-0.5	0.0	-0.5	-0.5	-0.1
Hair Pigment	0.0	1.3	7.5	0.7	1.8	0.2	0.9	-0.0	1.0	0.9	0.7	0.1	0.5	1.2	0.8	0.5	1.5	2.0	1.2	2.7	0.9	1.1	0.7

Hub : Genes

TMED6

Models

Trait associations