[Hub]/) : Traits : Leg fat percentage (left) : ← →

chr2:24,021,231-26,088,769

Best TWAS P=1.15e-44 · Best GWAS P=6.88e-39 conditioned to 0.668

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	12.8	-14.0	1.1e-44	-0.89	0.01	0.99	TRUE
20	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-8.9	-7.4	1.6e-13	-0.30	1.00	0.00	TRUE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	C2orf84	0.13	0.07	blup	56	0.05	1.5e-02	5.0	5.3	9.4e-08	0.10	0.02	0.14	TRUE
15	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	11.8	13.6	5.3e-42	0.87	0.66	0.34	FALSE
11	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	11.0	-13.5	1.8e-41	-0.92	0.01	0.99	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	12.4	-13.4	8.6e-41	-0.90	0.64	0.36	FALSE
14	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	12.4	13.3	1.8e-40	0.87	0.72	0.28	FALSE
12	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	11.0	-12.9	8.0e-38	-0.82	0.02	0.97	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	12.1	-12.5	5.0e-36	-0.93	0.01	0.96	FALSE
6	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	11.0	12.5	6.4e-36	0.70	0.98	0.02	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	12.1	11.9	7.1e-33	0.87	0.07	0.92	FALSE
13	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	11.8	11.8	3.6e-32	0.80	0.77	0.23	FALSE
26	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	8.4	-11.6	3.2e-31	-0.88	0.03	0.94	FALSE
7	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	11.0	11.0	3.8e-28	0.59	0.48	0.48	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	8.0	-10.8	3.0e-27	-0.49	0.48	0.25	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	7.6	10.7	1.2e-26	0.82	0.04	0.90	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	12.1	-10.6	2.9e-26	-0.84	0.02	0.97	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-10.1	-10.1	6.1e-24	-0.65	0.56	0.06	FALSE
19	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	13.0	-7.3	2.4e-13	-0.63	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-6.8	7.3	3.6e-13	0.41	0.98	0.00	FALSE
16	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-1.5	-7.2	5.7e-13	-0.37	0.06	0.08	FALSE
30	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-8.9	-7.1	1.1e-12	-0.32	0.01	0.57	FALSE
21	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	1.6	-6.8	8.8e-12	-0.51	0.57	0.38	FALSE
29	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-1.4	-6.8	9.3e-12	-0.21	0.37	0.62	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-1.4	-6.8	1.3e-11	-0.23	0.87	0.12	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-1.4	-6.6	4.6e-11	-0.26	0.01	0.41	FALSE
27	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	2.8	-6.4	1.8e-10	-0.56	0.36	0.59	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	-4.8	-6.1	8.5e-10	-0.36	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-1.4	-6.0	2.2e-09	-0.20	0.97	0.03	FALSE
31	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-1.9	-5.8	7.4e-09	-0.11	0.01	0.29	FALSE
10	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	2.5	5.6	1.9e-08	0.45	0.08	0.13	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	NCOA1	0.02	0.01	blup	77	0.01	1.2e-02	-4.2	-5.2	2.1e-07	-0.23	0.11	0.07	FALSE