Best TWAS P=7.63e-32 · Best GWAS P=1.54e-22 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | HIP1R | 0.06 | 0.02 | lasso | 6 | 0.04 | 1.9e-05 | -5.6 | -5.5 | 4.2e-08 | 0.01 | 0.18 | 0.02 | FALSE |
2 | GTEx | Adipose Subcutaneous | CCDC92 | 0.23 | 0.04 | enet | 27 | 0.16 | 6.9e-13 | -6.3 | 10.6 | 1.9e-26 | 0.48 | 0.15 | 0.85 | FALSE |
3 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | 9.4 | 11.7 | 1.5e-31 | 0.87 | 0.02 | 0.97 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-380L11.4 | 0.08 | 0.06 | lasso | 4 | 0.04 | 1.9e-04 | 5.8 | 5.2 | 1.8e-07 | 0.58 | 0.14 | 0.84 | FALSE |
5 | GTEx | Adipose Visceral Omentum | CCDC92 | 0.19 | 0.02 | lasso | 8 | 0.09 | 3.3e-05 | 9.5 | 11.5 | 8.0e-31 | 0.63 | 0.04 | 0.95 | TRUE |
6 | GTEx | Adipose Visceral Omentum | RP11-380L11.3 | 0.15 | 0.03 | lasso | 5 | 0.01 | 1.4e-01 | 7.4 | 11.7 | 7.6e-32 | 0.65 | 0.04 | 0.76 | TRUE |
7 | GTEx | Artery Aorta | P2RX4 | 0.20 | 0.03 | enet | 28 | 0.05 | 1.6e-03 | -3.6 | -5.1 | 2.9e-07 | 0.04 | 0.03 | 0.90 | TRUE |
8 | GTEx | Artery Tibial | PITPNM2 | 0.11 | 0.05 | lasso | 4 | 0.04 | 2.7e-04 | -5.5 | 6.1 | 1.3e-09 | 0.06 | 0.70 | 0.02 | FALSE |
9 | GTEx | Artery Tibial | RP11-380L11.4 | 0.14 | 0.12 | lasso | 4 | 0.12 | 2.2e-09 | 9.4 | 9.3 | 1.4e-20 | 0.95 | 0.04 | 0.96 | TRUE |
10 | GTEx | Brain Putamen basal ganglia | WDR66 | 0.25 | 0.01 | enet | 16 | -0.01 | 5.6e-01 | 5.3 | -5.4 | 8.6e-08 | 0.01 | 0.06 | 0.25 | FALSE |
11 | GTEx | Breast Mammary Tissue (Male) | CCDC92 | 0.06 | -0.01 | lasso | 3 | 0.00 | 4.3e-01 | 8.5 | 9.0 | 2.3e-19 | 0.85 | 0.04 | 0.14 | FALSE |
12 | GTEx | Breast Mammary Tissue (Female) | KDM2B | 0.13 | 0.00 | lasso | 3 | 0.01 | 1.2e-01 | -4.0 | 5.1 | 2.9e-07 | 0.10 | 0.05 | 0.06 | TRUE |
13 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | 8.4 | 8.4 | 3.8e-17 | 0.89 | 0.04 | 0.25 | TRUE |
14 | GTEx | Breast Mammary Tissue (Female) | C12orf65 | 0.06 | 0.00 | enet | 13 | -0.01 | 6.5e-01 | -3.8 | -5.3 | 1.3e-07 | -0.08 | 0.04 | 0.22 | FALSE |
15 | GTEx | Cells Transformed fibroblasts | BCL7A | 0.06 | 0.01 | lasso | 4 | 0.01 | 3.1e-02 | 4.7 | -7.3 | 3.7e-13 | -0.04 | 0.09 | 0.05 | TRUE |
16 | GTEx | Cells Transformed fibroblasts | CCDC92 | 0.09 | 0.00 | enet | 28 | 0.01 | 3.8e-02 | 7.6 | 6.2 | 4.8e-10 | 0.40 | 0.07 | 0.25 | FALSE |
17 | GTEx | Colon Sigmoid | RP11-380L11.4 | 0.21 | 0.12 | lasso | 3 | 0.08 | 1.1e-03 | 9.4 | 9.4 | 7.1e-21 | 0.91 | 0.04 | 0.89 | FALSE |
18 | GTEx | Colon Transverse | MLXIP | 0.20 | 0.18 | enet | 23 | 0.14 | 5.8e-07 | 5.6 | 5.3 | 9.7e-08 | -0.08 | 1.00 | 0.00 | FALSE |
19 | GTEx | Colon Transverse | SNRNP35 | 0.18 | 0.02 | lasso | 8 | 0.04 | 6.5e-03 | -3.8 | 6.9 | 4.2e-12 | 0.15 | 0.08 | 0.07 | TRUE |
20 | GTEx | Esophagus Mucosa | KDM2B | 0.11 | 0.04 | enet | 22 | 0.10 | 4.1e-07 | 3.3 | 6.7 | 2.1e-11 | 0.04 | 0.86 | 0.07 | TRUE |
21 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | 8.6 | 8.7 | 2.5e-18 | 0.89 | 0.09 | 0.81 | FALSE |
22 | GTEx | Esophagus Mucosa | HIP1R | 0.21 | 0.05 | lasso | 5 | 0.07 | 1.5e-05 | 4.0 | 7.3 | 3.5e-13 | -0.05 | 0.47 | 0.26 | TRUE |
23 | GTEx | Esophagus Muscularis | RP11-380L11.4 | 0.27 | 0.29 | lasso | 8 | 0.27 | 1.0e-16 | 9.4 | 9.4 | 4.3e-21 | 0.94 | 0.04 | 0.96 | FALSE |
24 | GTEx | Heart Atrial Appendage | CCDC92 | 0.12 | 0.11 | enet | 9 | 0.11 | 1.1e-05 | 6.7 | 8.9 | 6.6e-19 | 0.79 | 0.06 | 0.92 | FALSE |
25 | GTEx | Heart Atrial Appendage | RP11-380L11.4 | 0.18 | 0.11 | lasso | 7 | 0.12 | 6.5e-06 | 9.5 | 10.2 | 2.1e-24 | 0.92 | 0.03 | 0.96 | FALSE |
26 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | 8.6 | 10.1 | 8.8e-24 | 0.87 | 0.09 | 0.91 | FALSE |
27 | GTEx | Lung | CCDC92 | 0.14 | 0.00 | enet | 10 | 0.01 | 1.1e-01 | 8.2 | 8.3 | 6.9e-17 | 0.18 | 0.18 | 0.11 | TRUE |
28 | GTEx | Lung | RP11-380L11.4 | 0.07 | 0.07 | lasso | 3 | 0.07 | 8.2e-06 | 9.5 | 9.4 | 7.7e-21 | 0.94 | 0.03 | 0.97 | FALSE |
29 | GTEx | Muscle Skeletal | RSRC2 | 0.06 | 0.03 | enet | 7 | 0.04 | 9.6e-05 | -2.4 | -5.2 | 1.7e-07 | -0.03 | 0.25 | 0.48 | FALSE |
30 | GTEx | Muscle Skeletal | RP11-380L11.4 | 0.14 | 0.03 | lasso | 8 | 0.03 | 4.0e-04 | 9.4 | 7.7 | 1.9e-14 | 0.90 | 0.02 | 0.97 | FALSE |
31 | GTEx | Nerve Tibial | CCDC92 | 0.16 | 0.01 | enet | 6 | 0.04 | 6.7e-04 | 8.2 | 9.6 | 1.1e-21 | 0.68 | 0.07 | 0.64 | FALSE |
32 | GTEx | Nerve Tibial | KNTC1 | 0.12 | 0.05 | lasso | 5 | 0.05 | 1.9e-04 | -5.8 | -6.2 | 5.3e-10 | 0.02 | 0.53 | 0.03 | FALSE |
33 | GTEx | Prostate | CCDC92 | 0.31 | 0.10 | enet | 42 | 0.11 | 9.0e-04 | 8.4 | 7.0 | 2.6e-12 | 0.48 | 0.06 | 0.75 | FALSE |
34 | GTEx | Skin Sun Exposed Lower leg | DDX55 | 0.13 | 0.05 | enet | 13 | 0.10 | 1.6e-08 | -3.4 | 5.1 | 2.9e-07 | 0.07 | 1.00 | 0.00 | FALSE |
35 | GTEx | Skin Sun Exposed Lower leg | CCDC92 | 0.11 | 0.00 | enet | 15 | 0.01 | 1.0e-01 | 7.6 | 6.8 | 1.0e-11 | 0.50 | 0.07 | 0.47 | FALSE |
36 | GTEx | Skin Sun Exposed Lower leg | RP11-380L11.4 | 0.04 | 0.02 | enet | 15 | 0.02 | 1.9e-02 | 9.5 | 8.3 | 7.3e-17 | 0.83 | 0.02 | 0.96 | FALSE |
37 | GTEx | Thyroid | CCDC92 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | 9.4 | 10.4 | 1.6e-25 | 0.89 | 0.03 | 0.94 | FALSE |
38 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | 8.4 | -9.2 | 4.3e-20 | -0.87 | 0.05 | 0.95 | FALSE |
39 | GTEx | Whole Blood | DDX55 | 0.13 | 0.04 | enet | 13 | 0.06 | 3.3e-06 | -3.3 | 5.4 | 5.5e-08 | 0.05 | 0.34 | 0.02 | FALSE |
40 | METSIM | Adipose | ABCB9 | 0.04 | 0.03 | enet | 19 | 0.03 | 7.7e-05 | -5.6 | -7.1 | 1.1e-12 | 0.12 | 0.08 | 0.65 | FALSE |
41 | METSIM | Adipose | CCDC92 | 0.10 | 0.01 | bslmm | 435 | 0.06 | 5.5e-10 | -4.0 | 10.5 | 8.4e-26 | 0.62 | 0.17 | 0.83 | FALSE |
42 | METSIM | Adipose | DNAH10 | 0.03 | 0.00 | bslmm | 475 | 0.01 | 3.2e-03 | 9.8 | 8.3 | 9.1e-17 | 0.66 | 0.01 | 0.92 | FALSE |
43 | METSIM | Adipose | MORN3 | 0.06 | 0.02 | lasso | 10 | 0.04 | 8.7e-07 | 5.1 | 6.2 | 7.5e-10 | 0.01 | 0.75 | 0.21 | FALSE |
44 | METSIM | Adipose | RP11-214K3.24 | 0.05 | 0.03 | bslmm | 444 | 0.02 | 2.7e-04 | 8.6 | 10.1 | 8.1e-24 | 0.73 | 0.04 | 0.92 | FALSE |
45 | NTR | Blood | ZNF664 | 0.02 | 0.00 | bslmm | 447 | 0.01 | 6.3e-04 | -4.6 | -5.7 | 1.5e-08 | -0.57 | 0.03 | 0.84 | FALSE |
46 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DNAH10 | 0.11 | 0.03 | blup | 99 | 0.05 | 8.2e-11 | 7.0 | 8.8 | 1.4e-18 | 0.71 | 0.04 | 0.96 | FALSE |
47 | The Cancer Genome Atlas | Colon Adenocarcinoma | MLXIP | 0.06 | 0.04 | lasso | 7 | 0.02 | 2.7e-02 | 5.4 | 5.5 | 2.9e-08 | -0.07 | 0.03 | 0.90 | FALSE |
48 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC92 | 0.07 | 0.02 | blup | 52 | 0.04 | 1.8e-02 | 8.4 | 8.9 | 7.2e-19 | 0.93 | 0.02 | 0.73 | FALSE |
49 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DNAH10 | 0.10 | 0.01 | blup | 98 | 0.02 | 3.7e-03 | 9.5 | 5.5 | 3.1e-08 | 0.64 | 0.03 | 0.83 | TRUE |
50 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC92 | 0.06 | 0.04 | enet | 8 | 0.05 | 1.7e-06 | 8.6 | 6.4 | 2.1e-10 | 0.75 | 0.06 | 0.91 | FALSE |
51 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DNAH10 | 0.07 | 0.03 | lasso | 3 | 0.05 | 7.4e-06 | 9.5 | 9.2 | 3.7e-20 | 0.80 | 0.02 | 0.97 | FALSE |
52 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MLXIP | 0.18 | 0.14 | lasso | 4 | 0.13 | 5.1e-04 | 4.8 | 5.2 | 2.2e-07 | -0.08 | 0.03 | 0.84 | FALSE |
53 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CCDC92 | 0.05 | 0.03 | blup | 52 | 0.03 | 5.8e-03 | 4.0 | 7.4 | 1.4e-13 | 0.91 | 0.04 | 0.66 | FALSE |
54 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MLXIP | 0.06 | 0.02 | blup | 68 | 0.04 | 1.2e-03 | 5.5 | 6.9 | 3.9e-12 | -0.03 | 0.03 | 0.81 | TRUE |
55 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | 8.2 | 8.6 | 7.0e-18 | 0.86 | 0.01 | 0.87 | FALSE |
56 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS33A | 0.06 | 0.00 | enet | 8 | 0.03 | 9.6e-04 | 4.8 | -5.7 | 1.1e-08 | 0.02 | 0.12 | 0.86 | FALSE |
57 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF664 | 0.06 | 0.05 | enet | 9 | 0.05 | 2.8e-05 | 9.4 | -9.7 | 4.4e-22 | -0.92 | 0.03 | 0.97 | FALSE |