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chr17:60,821,100-64,251,733

Best TWAS P=5.32e-43 · Best GWAS P=7.3e-41 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-13.18	13.7	5.3e-43	-0.98	0.00	1.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	10.52	7.8	4.7e-15	-0.24	0.78	0.02	TRUE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	2.84	-7.6	4.1e-14	0.66	0.02	0.93	TRUE
29	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	1.68	-6.5	5.8e-11	0.59	0.35	0.06	TRUE
50	YFS	Blood	AXIN2	0.20	0.05	enet	34	0.10	5.1e-31	4.88	-6.4	2.1e-10	0.01	1.00	0.00	TRUE
52	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	9.79	6.1	9.4e-10	-0.10	1.00	0.00	TRUE
20	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	9.58	5.9	3.3e-09	-0.23	0.09	0.09	TRUE
30	GTEx	Lung	TEX2	0.04	0.02	enet	13	0.01	5.0e-02	2.33	5.6	1.7e-08	-0.08	0.15	0.03	TRUE
28	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	1.37	5.3	9.2e-08	-0.28	0.06	0.26	TRUE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-13.39	13.0	8.6e-39	-0.99	0.00	0.94	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-13.18	12.1	1.3e-33	-0.89	0.02	0.88	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-11.30	-11.3	1.3e-29	0.76	0.01	0.96	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-13.39	-11.0	3.0e-28	0.74	0.00	1.00	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-11.69	11.0	4.6e-28	-0.70	0.04	0.30	FALSE
24	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-10.90	-10.8	2.3e-27	0.74	0.22	0.31	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-10.83	-10.8	2.4e-27	0.75	0.00	0.90	FALSE
49	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	10.32	-10.4	3.4e-25	0.39	0.99	0.00	FALSE
9	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	10.28	10.3	9.9e-25	-0.39	0.83	0.02	FALSE
25	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-11.45	-10.2	1.6e-24	0.74	0.45	0.16	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-10.83	10.0	1.3e-23	-0.73	0.00	0.79	FALSE
43	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	9.79	-9.7	2.0e-22	0.37	0.89	0.06	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	9.55	9.7	3.7e-22	-0.36	1.00	0.00	FALSE
26	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	9.57	9.6	8.1e-22	-0.35	0.68	0.02	FALSE
16	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	9.56	9.6	1.1e-21	-0.36	0.05	0.13	FALSE
40	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	9.55	9.6	1.1e-21	-0.34	0.96	0.00	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	9.52	-9.5	1.7e-21	0.36	0.33	0.04	FALSE
33	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	9.52	9.5	1.7e-21	-0.35	0.95	0.02	FALSE
12	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	9.55	9.5	2.2e-21	-0.36	0.95	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-10.83	-9.5	2.4e-21	0.68	0.46	0.53	FALSE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	9.57	9.4	5.1e-21	-0.34	1.00	0.00	FALSE
41	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	9.52	9.3	9.9e-21	-0.34	0.46	0.05	FALSE
51	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	8.18	-9.0	1.6e-19	0.42	1.00	0.00	FALSE
31	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	8.99	9.0	2.3e-19	-0.36	0.94	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	9.55	8.8	1.8e-18	-0.49	0.68	0.12	FALSE
60	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	2.72	8.7	2.5e-18	-0.70	0.01	0.91	FALSE
48	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	10.32	-8.7	3.7e-18	0.42	1.00	0.00	FALSE
36	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	9.56	8.6	9.8e-18	-0.28	0.13	0.05	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	8.99	8.6	1.2e-17	-0.27	0.07	0.06	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	9.52	-8.5	2.2e-17	0.33	0.20	0.05	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	9.79	8.4	4.0e-17	-0.26	0.61	0.03	FALSE
15	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	8.18	8.2	1.7e-16	-0.29	0.07	0.06	FALSE
32	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-10.77	-8.1	4.3e-16	0.59	0.78	0.08	FALSE
35	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	9.55	8.0	1.1e-15	-0.27	0.14	0.16	FALSE
10	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	10.52	-7.8	4.1e-15	0.21	0.14	0.06	FALSE
39	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	9.79	-7.7	1.0e-14	0.22	0.99	0.00	FALSE
64	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	9.52	7.7	1.2e-14	-0.21	0.02	0.05	FALSE
22	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	9.60	-7.6	4.1e-14	0.19	0.96	0.00	FALSE
34	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	9.56	-7.5	7.1e-14	0.20	0.99	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	9.55	7.2	4.7e-13	-0.34	0.31	0.09	FALSE
23	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	5.78	7.0	2.2e-12	-0.29	0.29	0.03	FALSE
13	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	8.99	6.8	9.2e-12	-0.13	0.15	0.06	FALSE
56	The Cancer Genome Atlas	Colon Adenocarcinoma	TCAM1P	0.05	0.03	blup	26	0.05	6.0e-04	2.90	6.8	1.2e-11	-0.63	0.03	0.80	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	9.56	-6.7	1.9e-11	0.14	0.99	0.00	FALSE
8	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	9.55	-6.7	2.2e-11	0.13	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCAM1P	0.02	0.03	blup	26	0.02	9.4e-04	2.06	6.7	2.3e-11	-0.62	0.03	0.62	FALSE
55	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CSH2	0.09	0.01	blup	37	0.08	5.7e-05	1.78	6.7	2.5e-11	-0.66	0.42	0.26	FALSE
66	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMC5	0.12	0.05	enet	19	0.07	6.2e-04	-11.30	-6.6	3.0e-11	0.53	0.01	0.84	FALSE
70	The Cancer Genome Atlas	Thyroid Carcinoma	TCAM1P	0.07	0.07	blup	26	0.08	2.8e-08	1.97	6.6	4.6e-11	-0.61	0.11	0.89	FALSE
46	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-4.03	6.5	6.0e-11	-0.56	0.03	0.89	FALSE
3	CommonMind	Brain Pre-frontal Cortex	TCAM1P	0.05	0.03	enet	8	0.04	4.1e-06	-11.34	6.5	1.1e-10	-0.62	0.83	0.16	FALSE
44	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-11.30	6.3	2.7e-10	-0.68	0.02	0.97	FALSE
21	GTEx	Esophagus Mucosa	PSMC5	0.11	0.09	lasso	4	0.14	1.1e-09	1.68	-6.3	3.0e-10	0.58	0.99	0.01	FALSE
45	GTEx	Whole Blood	CCDC47	0.05	0.00	lasso	5	0.01	9.8e-02	-0.59	-6.0	1.6e-09	0.28	0.07	0.07	FALSE
38	GTEx	Skin Sun Exposed Lower leg	PSMC5	0.07	0.02	enet	23	0.02	1.6e-02	2.72	-6.0	2.3e-09	0.54	0.23	0.06	FALSE
18	GTEx	Cells Transformed fibroblasts	CD79B	0.20	0.00	lasso	4	0.00	4.3e-01	-2.50	-5.9	3.7e-09	0.32	0.11	0.08	FALSE
27	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	9.51	5.9	4.7e-09	-0.04	0.52	0.02	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	9.79	-5.6	2.3e-08	0.07	0.24	0.02	FALSE
42	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	2.12	5.5	3.6e-08	-0.18	0.08	0.04	FALSE
47	METSIM	Adipose	RP11-214C8.2	0.03	0.00	blup	304	0.01	4.2e-03	-0.40	-5.4	7.3e-08	0.48	0.23	0.11	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FTSJ3	0.30	0.12	enet	10	0.18	6.7e-08	1.81	-5.2	1.8e-07	0.53	0.18	0.81	FALSE