TWAS hub - AXIN2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.038	0.0190	0.0130	0.003	0.009	-0.002	0.008	0.009	1.1e-01	2.7e-02	8.4e-01	2.8e-02	2.2e-02
2	GTEx	Cells Transformed fibroblasts	0.089	0.0390	0.0093	0.043	NA	0.022	NA	0.023	3.2e-04	NA	8.2e-03	NA	6.7e-03
3	YFS	Blood	0.199	0.0346	0.0000	0.050	0.066	0.100	0.070	0.061	5.3e-16	1.2e-20	5.1e-31	6.9e-22	2.8e-19

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Hair/balding pattern: Pattern 2	17.3	22.0	49.7	2.7	-7.0	3.0
Medication: Seretide 50 evohaler	5.3	6.1	9.9	-3.1	2.6	1.2
Hand grip strength (right)	4.9	13.4	31.5	2.9	-0.4	-5.6
Standing height	4.9	48.8	136.9	0.4	3.1	-11.7
Height	4.6	89.2	231.0	0.1	6.0	-15.2
Hand grip strength (left)	4.6	12.0	22.9	3.6	-0.6	-4.8
Qualifications: nursing, teaching	4.5	7.0	20.5	-0.1	0.7	-4.5
Sitting height	4.4	30.9	85.6	1.8	2.0	-9.2
Mood swings	4.3	7.7	16.1	-1.4	-2.2	4.0
Long-standing illness, disability or infirmity	4.1	6.2	15.2	-1.6	-0.9	3.9
Number of self-reported non-cancer illnesses	3.8	6.6	15.1	-1.7	-1.4	3.9
Osteoarthritis (self-reported)	3.6	4.6	9.7	-1.2	-3.1	1.6
Trunk fat-free mass	3.5	20.0	57.0	1.6	0.5	-7.5
Trunk predicted mass	3.5	19.8	56.2	1.7	0.5	-7.5
Medication: Lansoprazole	3.4	3.9	5.9	-1.9	1.5	2.4
Forced vital capacity (FVC), Best measure	3.3	12.1	31.2	0.4	2.2	-5.6
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.9	17.4	0.7	1.7	-4.2
Back pain experienced in last month	3.2	4.6	9.9	-3.2	0.9	1.8
Number of operations (self-reported)	3.2	4.7	7.9	1.2	-2.8	2.2
Multivitamins +/- minerals	3.1	3.9	5.7	2.4	-1.7	-1.8
Whole body fat-free mass	3.1	17.4	50.0	1.5	0.5	-7.1
Birth weight	3.0	6.5	9.4	-3.1	2.4	-2.1
Arm predicted mass (right)	3.0	15.2	43.6	1.3	0.5	-6.6
Illnesses of siblings: Diabetes	3.0	3.7	7.0	-0.8	-1.8	2.6
Ever had bowel cancer screening	3.0	3.5	5.7	-2.0	2.4	1.0
Whole body water mass	3.0	17.2	49.0	1.5	0.4	-7.0
Average weekly champagne plus white wine intake	3.0	4.1	11.7	0.7	-0.1	-3.4
Forced vital capacity (FVC)	2.8	10.8	29.2	0.7	1.6	-5.4
Arm fat-free mass (right)	2.8	14.2	40.4	1.4	0.3	-6.4
Wheeze or whistling in the chest in last year	2.8	5.1	8.4	-1.9	1.8	2.9
Worry (Nagel 2018)	2.7	5.6	9.9	0.1	-3.1	2.6
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	8.8	-3.0	1.4	1.5
Forced expiratory volume in 1-second (FEV1)	2.7	9.0	25.0	0.9	1.1	-5.0
Leg fat-free mass (right)	2.7	14.3	40.8	1.3	0.5	-6.4
Leg predicted mass (right)	2.7	14.4	41.2	1.3	0.4	-6.4
Forced expiratory volume in 1-second (FEV1), Best measure	2.6	8.4	23.0	0.5	1.4	-4.8
Had major operations	2.6	3.1	5.3	1.0	-1.7	2.3
Basal metabolic rate	2.6	14.4	41.5	1.3	0.3	-6.4
Arm fat-free mass (left)	2.6	13.1	36.8	1.5	0.1	-6.1
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	9.1	0.5	1.7	-3.0
Birth weight of first child	2.4	4.3	10.3	1.4	0.8	-3.2
Comparative height size at age 10	2.3	12.9	34.8	-1.2	1.5	-5.9
Depressed Affect (Nagel 2018)	2.2	4.6	10.1	-1.1	-1.6	3.2
Heel T-Score	2.2	17.6	51.8	1.0	0.1	-7.2
Handedness (chirality/laterality): Left-handed	2.2	2.6	4.8	-2.2	1.5	0.8
Smoking status: Current	2.2	3.5	7.5	-1.5	0.9	2.7
Pain type(s) experienced in last month: Hip pain	2.2	2.8	4.9	-0.2	-2.2	1.8
Arm predicted mass (left)	2.2	11.3	31.9	1.4	0.0	-5.7
Neuroticism (Nagel 2018)	2.1	4.9	8.1	-0.3	-2.5	2.9
Leg predicted mass (left)	2.1	11.0	31.9	1.0	0.4	-5.7
Qualifications: College or University degree	2.1	6.6	11.2	1.7	-2.4	-3.3
Ulcerative Colitis	2.0	2.8	6.0	-0.7	-1.4	2.4
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.0	-1.3	0.2	2.5
Vitamin and mineral supplements	2.0	2.8	4.2	-2.1	1.8	0.9
Leg fat-free mass (left)	2.0	10.8	31.4	1.0	0.3	-5.6
Noisy workplace	2.0	2.4	3.3	-1.8	1.6	1.2
Hair/balding pattern: Pattern 4	2.0	4.9	11.6	0.1	-1.8	-3.4
Hearing aid user	2.0	2.3	4.1	1.7	-0.2	2.0
Unable to work because of sickness or disability	2.0	2.6	7.2	-0.4	-0.6	2.7
Verbal and Numeric Reasoning (VNR)	1.9	4.5	11.9	1.0	-3.5	0.7
Had other major operations	1.9	2.4	5.3	-0.3	-2.3	1.3
Hypothyroidism/myxoedema (self-reported)	1.9	3.7	5.0	-1.7	-1.9	2.2
Number of children fathered	1.9	2.2	4.2	-1.3	2.0	-0.7
Medication: Atorvastatin	1.9	2.3	3.8	-1.7	-0.6	1.9
Current tobacco smoking	1.8	3.0	6.2	-1.3	0.9	2.5
Peak expiratory flow (PEF)	1.8	4.3	10.4	0.8	1.4	-3.2
Medication: Aspirin	1.8	2.4	4.4	-1.1	1.2	2.1
Depression (Nagel 2018)	1.7	2.5	4.7	-0.1	-2.2	1.7
Neuroticism (2016)	1.7	2.5	6.4	-0.7	-0.8	2.5
Ever had hysterectomy (womb removed)	1.7	2.0	3.6	0.4	-1.5	1.9
Nervous feelings	1.7	3.1	4.7	-0.6	-2.2	2.1
Medication: Cholesterol lowering	1.7	2.6	7.2	-0.3	-0.7	2.7
Medication for pain relief, constipation, heartburn	1.7	2.8	6.2	1.3	-0.7	-2.5
Medication: Blood pressure	1.7	2.9	6.3	-0.8	-1.4	2.5
Angina (self-reported)	1.7	2.2	3.5	-1.5	0.9	1.9
Ulcerative Colitis (UC)	1.6	3.0	5.9	-1.7	-0.5	2.4
Hearing difficulty/problems: Yes	1.6	2.5	3.9	-1.7	2.0	0.8
Medication: Levothyroxine sodium	1.6	2.7	3.8	-1.8	-1.0	1.9
Father’s age at death	1.6	2.1	5.6	0.2	-0.8	-2.4
Prospective memory result	1.6	2.0	4.0	-1.1	-0.8	2.0
Mouth/teeth dental problems: Bleeding gums	1.6	2.1	3.4	-1.6	0.4	1.8
Medication: Aspirin	1.6	2.0	3.7	-1.3	0.9	1.9
Irritability	1.6	2.7	4.7	-0.6	-1.7	2.2
Bipolar Disorder (2011)	1.5	1.4	3.4	-1.8	-0.1	0.9
Heart attack	1.5	1.9	5.2	-0.7	-0.3	2.3
Neuroticism score	1.5	3.2	5.9	-0.1	-2.4	1.9
Migraine (self-reported)	1.5	1.9	3.5	-1.2	1.9	-0.9
Knee pain experienced in last month	1.5	2.3	5.4	0.6	-1.1	2.3
Supplements: Fish oil (including cod liver oil)	1.5	1.9	5.0	0.4	-2.2	0.8
Lupus	1.4	2.1	6.0	-0.1	-0.5	2.5
Waist Hip Ratio (WHR)	1.4	6.4	16.2	-1.7	4.0	0.2
Angina	1.4	1.9	3.4	-1.3	0.7	1.8
Taking other prescription medications	1.4	2.1	5.5	-0.4	-0.8	2.3
Mouth/teeth dental problems	1.4	2.2	3.7	-0.1	1.7	-1.9
Alcohol intake versus 10 years previously	1.4	2.1	2.5	-1.4	1.6	1.2
Falls in the last year	1.4	1.8	4.0	-2.0	0.5	1.1
Tense / ‘highly strung’	1.4	2.3	4.8	0.3	-2.2	1.4
Leg pain on walking	1.4	1.7	3.9	-2.0	1.1	0.3
Ever taken oral contraceptive pill	1.4	1.6	4.7	0.1	2.2	-0.1
Pack years of smoking	1.4	2.0	3.6	-1.9	1.5	-0.1
Ovarian Cancer	1.3	1.7	3.3	-0.0	1.8	1.3
Qualifications: None of the above	1.3	2.8	7.2	-1.0	-0.6	2.7
Mouth/teeth dental problems: Dentures	1.3	2.2	3.0	0.9	-1.7	1.7
Overall health rating	1.3	2.8	6.7	-0.9	-0.9	2.6
Illnesses of father: Heart disease	1.3	1.7	3.8	1.9	-0.2	-1.2
Osteoporosis (self-reported)	1.3	1.6	2.4	-1.5	-0.9	1.3
Smoking Status	1.2	2.8	7.7	-0.1	0.7	2.8
Number of treatments/medications taken	1.2	2.2	5.3	-1.1	-0.4	2.3
Medication: Co-codamol	1.2	1.3	3.4	-0.7	0.3	1.9
Diabetes (mother)	1.2	1.6	2.9	1.7	-0.6	-1.2
Supplements: Glucosamine	1.2	1.6	3.5	1.9	-0.7	-0.8
Medication: Ramipril	1.2	1.6	4.2	0.7	-2.0	-0.1
Illnesses of mother	1.2	1.4	2.6	-1.3	0.1	1.6
Comparative body size at age 10	1.2	3.3	7.6	-2.8	1.3	-0.8
Neck or shoulder pain in last month	1.2	1.7	3.1	-1.3	0.5	1.8
Breast cancer (self-reported)	1.2	1.4	4.1	0.2	-0.2	2.0
Heart attack/myocardial infarction (self-reported)	1.2	1.6	4.1	-0.8	-0.3	2.0
Neuroticism	1.1	2.6	3.9	-0.3	-2.0	1.9
Chronotype (morning person)	1.1	2.6	6.6	0.4	1.0	-2.6
Average weekly spirits intake	1.1	1.3	1.9	-0.6	-1.3	1.4
Medication: Metformin	1.1	1.6	4.1	-2.0	-0.2	0.8
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.2	-1.0	-0.7	1.5
Qualifications: CSEs or equivalent	1.1	1.5	3.4	0.8	1.9	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	6.2	0.2	1.2	-2.5
Hair/balding pattern: Pattern 3	1.1	1.6	2.3	-0.8	1.4	-1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	6.3	0.8	-0.7	-2.5
Depression (self-reported)	1.1	1.3	2.2	-1.5	-1.2	0.6
Worry too long after embarrassment	1.1	1.9	3.7	1.9	-1.0	-0.9
Mouth/teeth dental problems: Loose teeth	1.1	1.3	2.2	1.3	-1.5	0.3
Diabetes diagnosed by doctor	1.1	1.9	3.4	-1.4	-0.6	1.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.1	2.3	4.0	0.3	2.0	-1.6
Miserableness	1.1	1.9	4.4	-1.0	-0.4	2.1
Hypothyroidism (self reported)	1.0	2.2	2.7	-1.6	-1.5	1.3
Supplements: Zinc	1.0	1.0	1.7	1.3	0.1	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	5.8	-0.2	0.8	-2.4
Weight	1.0	5.1	15.4	0.3	0.1	-3.9
Number of live births	1.0	1.5	3.8	1.9	-0.2	0.8
Length of working week for main job	1.0	1.1	3.1	-0.3	1.7	0.2
Medication: Ventolin 100micrograms inhaler	1.0	1.3	3.3	-0.7	1.8	0.0
Commuting to job workplace: Walk	1.0	1.0	1.6	0.7	1.1	-1.2
Myopia	1.0	1.5	3.7	0.0	0.8	-1.9
Fed-up feelings	0.9	1.7	4.8	0.3	-0.4	2.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.0	-1.0	-0.7	1.4
Financial difficulties in last 2 years	0.9	1.2	1.9	-1.4	1.2	0.4
Leg fat percentage (right)	0.9	3.1	7.3	-1.2	-0.7	2.7
Age at last live birth	0.9	1.3	1.5	1.2	-1.1	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	1.6	-0.7	-1.3	1.0
Financial situation satisfaction	0.9	1.1	1.8	-1.0	1.4	0.6
Eye problems/disorders: Glaucoma	0.9	1.0	2.1	-0.9	1.5	-0.4
Medication: Paracetamol	0.9	1.4	2.4	-1.5	0.6	1.1
Bipolar Disorder (2018)	0.8	1.3	3.5	-0.7	0.2	-1.9
Primary Biliary Cirrhosis	0.8	1.1	2.1	-0.6	-0.9	1.4
Respiratory disease	0.8	1.8	2.8	-1.1	1.2	1.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.5	-0.1	0.7	1.6
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	1.0	-0.9	-1.0	1.0
Severe depression (siblings)	0.8	0.9	2.0	-0.2	-0.8	-1.4
Pack years adult smoking proportion	0.8	1.3	2.6	-1.6	1.1	0.0
Townsend deprivation index at recruitment	0.8	1.1	1.6	-1.0	0.9	1.3
Diabetes (self-reported)	0.8	1.3	3.5	-0.1	-1.9	0.6
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.3	0.1	-1.5	1.0
Fluid intelligence score	0.8	1.6	4.6	0.3	-2.1	-0.3
Worrier / anxious feelings	0.8	1.4	4.0	-0.1	-2.0	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	1.4	1.2	-0.6	-1.0
Asthma	0.8	1.7	4.5	-0.6	0.4	2.1
Breastfed as a baby	0.8	1.0	2.5	1.6	0.3	-0.7
Mean time to correctly identify matches	0.8	1.5	2.3	-1.5	1.2	0.8
Chest pain or discomfort	0.8	1.1	2.5	-1.6	0.9	-0.1
Asthma (self-reported)	0.8	1.7	3.9	-0.8	0.6	2.0
Illnesses of father: None of the above (group 1)	0.8	0.9	2.5	-1.6	0.5	0.1
Pain experienced in last month	0.8	1.4	2.3	1.3	-0.3	-1.5
Alcohol drinker status: Previous	0.8	0.9	1.9	-1.4	0.3	0.7
Schizophrenia vs Biploar Disorder	0.7	0.9	1.7	1.0	-0.2	1.3
Relative age of first facial hair	0.7	1.5	2.7	1.6	1.0	1.0
Medication: Atenolol	0.7	0.9	2.5	-0.5	-0.1	1.6
High blood pressure (mother)	0.7	1.0	1.8	1.0	0.3	-1.4
Illnesses of siblings	0.7	1.0	2.1	0.3	0.9	-1.4
Exposure to tobacco smoke at home	0.7	0.7	1.6	-0.6	1.3	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.0	0.1	1.4	-0.6
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.6	0.6	1.2	-0.7
Heart disease (siblings)	0.7	0.9	2.3	0.1	-0.7	1.5
Intelligence (Savage-Jansen 2018)	0.6	1.8	4.2	1.1	-2.0	-0.3
Coronary Artery Disease (CAD)	0.6	0.7	1.1	-1.1	0.0	1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.4	-1.2	-1.1	0.8
Average weekly fortified wine intake	0.6	0.7	1.2	-0.3	-1.1	-0.9
Serious illness, injury or assault to yourself	0.6	0.8	2.0	0.1	-0.6	1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.9	-0.9	-0.2	1.4
Impedance of arm (right)	0.6	2.7	4.6	-2.2	1.8	0.6
Pulse rate	0.6	1.0	2.2	1.5	-0.1	-0.9
Glaucoma (self-reported)	0.6	0.8	1.3	0.4	1.1	-0.9
High blood pressure (siblings)	0.6	0.8	1.5	-0.5	-0.9	1.2
Number of full brothers	0.6	0.7	1.2	1.1	-0.0	1.0
Age at first live birth	0.6	1.1	1.7	1.2	-0.5	-1.3
Number of full sisters	0.6	0.8	1.8	1.3	0.7	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.7	-0.7	0.5	-1.3
Mineral and other dietary supplements	0.6	0.8	1.5	-0.8	1.2	0.3
Leg fat percentage (left)	0.6	2.0	4.1	-1.3	-0.5	2.0
Alzheimer’s Disease (in father)	0.5	0.6	1.4	-1.2	0.5	0.4
Triglycerides	0.5	0.8	1.2	1.1	-1.0	0.6
Hair Pigment	0.5	12.9	28.7	1.6	5.4	-2.7
Maternal smoking around birth	0.5	0.7	1.0	0.9	-0.5	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.9	0.7	-0.5
Chronic bronchitis/emphysema (father)	0.5	0.5	1.0	-0.6	1.0	0.5
Number of incorrect matches in round	0.5	0.9	2.6	0.0	1.6	0.1
Had menopause	0.5	0.7	1.3	1.1	-0.5	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.7	1.8	0.4	-0.2	1.4
Ever highly irritable/argumentative for 2 days	0.5	0.5	0.8	-0.9	0.8	0.5
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.1	0.5	0.3	-1.4
Medication: Amlodipine	0.5	0.7	1.4	-0.8	-0.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	1.0	-1.0	-0.1	0.9
Medication: Ibuprofen	0.5	0.5	0.8	-0.2	0.9	0.9
Medication: Omeprazole	0.5	0.6	0.8	-0.9	0.7	0.6
Heart disease (mother)	0.5	0.6	1.3	1.1	-0.2	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.5	1.4	1.2	-0.0	0.4
Hypertension (Self-reported)	0.5	1.3	1.9	-0.6	-1.4	1.3
Smoking status: Previous	0.5	0.7	1.8	1.3	-0.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.5	1.1	0.2	-0.7	1.1
Guilty feelings	0.5	0.8	1.4	-0.2	-1.2	-1.0
Commuting to job workplace: Public transport	0.5	0.6	1.1	1.1	-0.5	-0.7
Ever smoked	0.5	0.9	1.4	-1.2	1.1	0.3
Diastolic blood pressure, automated reading	0.5	1.6	3.1	1.7	-1.3	0.5
Ever depressed for a whole week	0.5	0.7	1.4	0.6	-0.5	1.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	2.7	0.4	1.1	-1.6
Basal cell carcinoma (self-reported)	0.5	0.6	1.8	0.0	1.3	-0.1
Alzheimer’s Disease (including proxy)	0.4	0.5	1.3	-1.1	0.5	0.0
Irritable Bowel Disease (IBD)	0.4	1.1	2.4	-0.9	0.1	1.5
Major Depression (MDD)	0.4	0.5	0.6	0.7	-0.5	0.8
Breast Cancer	0.4	1.1	1.5	0.4	1.2	-1.2
Age at First Birth	0.4	0.5	1.1	0.5	-1.0	-0.6
Body Mass Index (BMI) (2010)	0.4	0.6	1.4	-1.2	0.3	-0.6
Blood White Count	0.4	2.7	4.7	-2.2	0.7	1.7
Systolic Blood Pressure	0.4	2.1	4.1	0.4	-2.0	1.5
Systolic blood pressure, automated reading	0.4	1.3	2.2	0.2	-1.5	1.2
Impedance of leg (right)	0.4	2.1	3.1	-1.8	1.2	1.2
Age when periods started (menarche)	0.4	1.1	1.5	-1.2	1.2	0.6
High blood pressure	0.4	1.1	1.7	-0.7	-1.0	1.3
Stomach or abdominal pain in last month	0.4	0.5	1.0	-1.0	-0.0	0.7
Impedance of leg (left)	0.4	2.1	3.3	-1.8	1.8	0.3
Alcohol usually taken with meals	0.4	0.7	1.6	0.1	0.6	-1.3
Medication: Simvastatin	0.4	0.6	1.8	0.1	-0.3	1.4
Happiness	0.4	0.5	0.9	-0.9	0.5	0.7
Medication: Paracetamol	0.4	0.7	1.6	-0.6	-0.3	1.3
Exposure to tobacco smoke outside home	0.4	0.5	0.9	-0.7	0.9	0.4
Health satisfaction	0.4	0.6	1.1	-0.6	-0.4	1.1
Eye problems/disorders: None of the above	0.4	0.5	1.1	0.4	-0.5	-1.0
Suffer from ‘nerves’	0.4	0.6	1.2	-0.4	-1.1	0.7
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	-1.2	0.2	-0.3
Supplements: Vitamin C	0.4	0.5	0.8	-0.1	-0.9	0.9
Average weekly red wine intake	0.4	0.6	1.6	-0.1	-0.2	-1.3
Eye problems/disorders: Cataract	0.4	0.4	0.7	0.8	0.3	0.7
Medication: Gliclazide	0.4	0.5	1.2	-1.1	0.4	-0.3
Wears glasses or contact lenses	0.4	0.5	0.8	0.8	0.9	-0.0
High cholesterol (Self-reported)	0.4	0.7	1.2	0.3	-0.9	1.1
Average weekly beer plus cider intake	0.4	0.6	1.1	0.3	0.7	1.0
Risk taking	0.4	0.6	0.8	0.3	0.9	-0.9
Age started oral contraceptive pill	0.4	0.5	0.8	0.9	-0.5	-0.7
Commuting to job workplace: Cycle	0.4	0.5	0.8	-0.9	-0.8	-0.2
Impedance of whole body	0.4	2.0	3.4	-1.6	1.9	0.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	0.5	-0.4	-1.4
Schizophrenia (2018)	0.3	0.6	1.3	1.1	-0.7	-0.3
HbA1C	0.3	0.4	1.1	-0.0	1.1	0.2
Schizophrenia (2014)	0.3	0.7	1.7	1.3	0.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.8	-0.5	-0.4	0.9
Blood Red Count	0.3	3.2	4.8	-0.6	-2.1	2.2
Cardiovascular Disease	0.3	1.1	2.8	0.2	-1.7	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.6	-1.3	-0.5	0.3
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.6	0.6	-0.2	-0.8
Body mass index (BMI)	0.3	1.3	2.0	0.1	-1.4	1.4
Trunk fat mass	0.3	1.3	2.4	-1.0	0.7	-1.6
Hearing difficulty/problems with background noise	0.3	0.5	0.9	-0.8	-0.3	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.5	-0.3	0.8
Allergy	0.3	0.7	1.1	1.1	0.6	-0.9
Pain all over the body in last month	0.3	0.4	0.9	0.1	0.4	-1.0
Arm fat percentage (right)	0.3	1.1	2.7	-0.7	-0.4	1.6
Lung cancer (father)	0.3	0.3	0.7	-0.5	0.8	-0.1
Pulse wave Arterial Stiffness index	0.3	0.4	1.0	0.3	0.1	-1.0
Impedance of arm (left)	0.3	1.6	3.1	-1.3	1.8	-0.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.7	0.1	-0.8	-0.6
Body fat percentage	0.3	1.2	2.1	-1.4	0.3	1.2
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.3	0.6	0.6	-0.5
Emphysema/chronic bronchitis	0.3	0.4	0.8	-0.6	0.9	-0.2
Mother’s age at death	0.3	0.3	0.3	-0.6	0.6	-0.6
Medication: Blood pressure	0.3	0.6	0.9	0.9	-1.0	-0.4
Medication: Lisinopril	0.3	0.3	0.4	0.6	-0.6	-0.5
Alcohol drinker status: Never	0.3	0.4	1.0	0.2	-1.0	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.7	0.6	0.4	0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.8	-0.9	0.5	0.3
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.7	-0.9	0.4	0.6
Alzheimer’s Disease (in mother)	0.2	0.2	0.5	0.3	-0.7	-0.2
Crohns Disease (2017)	0.2	0.4	1.2	0.2	1.1	-0.1
Reaction Time	0.2	0.5	0.7	-0.7	0.8	0.4
Prostate Cancer	0.2	0.3	0.4	-0.6	0.6	-0.2
Blood Eosinophil Count	0.2	1.3	2.0	-1.3	0.2	1.4
Allergy or Eczema	0.2	0.5	1.6	-1.3	-0.0	0.1
Medication for hormone replacement therapy	0.2	0.2	0.4	0.3	-0.2	0.6
Trunk fat percentage	0.2	1.0	2.3	-1.5	0.5	0.6
Waist circumference	0.2	0.8	1.5	-1.2	0.3	0.8
Hip circumference	0.2	0.9	2.3	0.1	-1.5	-0.4
Time employed in main current job	0.2	0.3	0.8	0.9	0.3	0.1
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.7	0.2	0.7
Shortness of breath walking on level ground	0.2	0.2	0.3	0.5	0.4	0.3
Whole body fat mass	0.2	0.7	1.2	-0.9	0.5	-1.1
Pulse rate, automated reading	0.2	0.7	2.0	-0.2	1.4	-0.4
Family relationship satisfaction	0.2	0.3	0.5	0.2	-0.7	0.5
Loneliness, isolation	0.2	0.2	0.3	-0.6	0.6	-0.1
Supplements: Calcium	0.2	0.3	0.6	0.1	0.5	0.8
Crohns Disease (2012)	0.1	0.1	0.2	-0.4	0.2	-0.4
Mean Putamen Volume	0.1	0.1	0.3	0.0	-0.1	-0.5
Fasting Glucose	0.1	0.2	0.5	-0.7	0.0	-0.0
Rheumatoid Arthritis	0.1	0.1	0.2	0.4	-0.3	-0.4
Blood Platelet Count	0.1	1.3	2.7	-0.9	1.6	0.7
BMI	0.1	0.4	0.7	-0.4	-0.8	0.6
Lung FEV1/FVC ratio	0.1	0.3	0.5	-0.5	0.7	0.3
Tanning	0.1	1.8	5.2	0.0	-2.3	0.4
Sensitivity / hurt feelings	0.1	0.1	0.2	0.4	-0.3	0.2
Frequency of depressed mood in last 2 weeks	0.1	0.1	0.3	-0.5	0.0	-0.2
Relative age voice broke	0.1	0.1	0.3	0.5	0.3	0.2
Past tobacco smoking	0.1	0.2	0.4	0.0	-0.2	-0.6
Pulse wave reflection index	0.1	0.2	0.4	-0.4	0.0	-0.6
Loud music exposure frequency	0.1	0.1	0.2	0.1	0.0	-0.5
Headache pain in last month	0.1	0.1	0.1	-0.4	0.3	-0.4
Medication: Allopurinol	0.1	0.2	0.5	0.2	-0.7	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.2	0.3	0.5	-0.5	-0.0
Alcohol intake frequency.	0.1	0.2	0.3	-0.4	-0.0	0.6
Arm fat percentage (left)	0.1	0.5	1.1	-0.3	-0.5	1.0
Friendships satisfaction	0.1	0.1	0.3	0.5	0.1	-0.0
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.3	-0.5	-0.3
Medication for cholesterol	0.1	0.2	0.6	-0.3	-0.2	0.7
Arm fat mass (left)	0.1	0.3	0.6	0.0	-0.4	-0.8
Illnesses of father: High blood pressure	0.1	0.2	0.3	-0.3	-0.4	-0.6
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.2	-0.2	0.6
Cholesterol lowering medication	0.1	0.1	0.2	0.3	-0.4	0.1
Leg fat mass (left)	0.1	0.3	0.4	-0.7	-0.1	-0.6
HDL Cholesterol	0.0	0.0	0.1	-0.2	-0.3	0.1
LDL Cholesterol	0.0	0.1	0.1	-0.0	-0.3	-0.2
Lung FVC	0.0	0.0	0.1	0.1	-0.3	-0.1
Diabetes (father)	0.0	0.0	0.1	0.1	-0.0	-0.3
Arm fat mass (right)	0.0	0.1	0.2	-0.1	-0.4	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.4	-0.3	-0.1
Gout (self-reported)	0.0	0.0	0.0	0.1	-0.1	-0.2
Pulse wave peak to peak time	0.0	0.0	0.0	-0.1	-0.0	0.1
Leg fat mass (right)	0.0	0.2	0.5	-0.7	-0.0	-0.1
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.2	0.0	0.1

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