Hub : Genes

AXIN2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.038 0.0190 0.0130 0.003 0.009 -0.002 0.008 0.009 1.1e-01 2.7e-02 8.4e-01 2.8e-02 2.2e-02
2 GTEx Cells Transformed fibroblasts 0.089 0.0390 0.0093 0.043 NA 0.022 NA 0.023 3.2e-04 NA 8.2e-03 NA 6.7e-03
3 YFS Blood 0.199 0.0346 0.0000 0.050 0.066 0.100 0.070 0.061 5.3e-16 1.2e-20 5.1e-31 6.9e-22 2.8e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.8 1.3 3.5 -0.7 0.2 -1.9
Bipolar Disorder or Schizophrenia 0.3 0.8 2.0 0.5 -0.4 -1.4
Depressed Affect (Nagel 2018) 2.2 4.6 10.1 -1.1 -1.6 3.2
Depression (Nagel 2018) 1.7 2.5 4.7 -0.1 -2.2 1.7
Intelligence (Savage-Jansen 2018) 0.6 1.8 4.2 1.1 -2.0 -0.3
Neuroticism (Nagel 2018) 2.1 4.9 8.1 -0.3 -2.5 2.9
Schizophrenia (2018) 0.3 0.6 1.3 1.1 -0.7 -0.3
Schizophrenia vs Biploar Disorder 0.7 0.9 1.7 1.0 -0.2 1.3
Worry (Nagel 2018) 2.7 5.6 9.9 0.1 -3.1 2.6
Alzheimer’s Disease (in mother) 0.2 0.2 0.5 0.3 -0.7 -0.2
Alzheimer’s Disease (in father) 0.5 0.6 1.4 -1.2 0.5 0.4
Alzheimer’s Disease (including proxy) 0.4 0.5 1.3 -1.1 0.5 0.0
Crohns Disease (2017) 0.2 0.4 1.2 0.2 1.1 -0.1
Irritable Bowel Disease (IBD) 0.4 1.1 2.4 -0.9 0.1 1.5
Ulcerative Colitis (UC) 1.6 3.0 5.9 -1.7 -0.5 2.4
Major Depression (MDD) 0.4 0.5 0.6 0.7 -0.5 0.8
Reaction Time 0.2 0.5 0.7 -0.7 0.8 0.4
Verbal and Numeric Reasoning (VNR) 1.9 4.5 11.9 1.0 -3.5 0.7
Breast Cancer 0.4 1.1 1.5 0.4 1.2 -1.2
Ovarian Cancer 1.3 1.7 3.3 -0.0 1.8 1.3
Prostate Cancer 0.2 0.3 0.4 -0.6 0.6 -0.2
Age at First Birth 0.4 0.5 1.1 0.5 -1.0 -0.6
Bipolar Disorder (2011) 1.5 1.4 3.4 -1.8 -0.1 0.9
Body Mass Index (BMI) (2010) 0.4 0.6 1.4 -1.2 0.3 -0.6
Coronary Artery Disease (CAD) 0.6 0.7 1.1 -1.1 0.0 1.1
Crohns Disease (2012) 0.1 0.1 0.2 -0.4 0.2 -0.4
Mean Putamen Volume 0.1 0.1 0.3 0.0 -0.1 -0.5
Fasting Glucose 0.1 0.2 0.5 -0.7 0.0 -0.0
HbA1C 0.3 0.4 1.1 -0.0 1.1 0.2
HDL Cholesterol 0.0 0.0 0.1 -0.2 -0.3 0.1
LDL Cholesterol 0.0 0.1 0.1 -0.0 -0.3 -0.2
Lupus 1.4 2.1 6.0 -0.1 -0.5 2.5
Neuroticism (2016) 1.7 2.5 6.4 -0.7 -0.8 2.5
Primary Biliary Cirrhosis 0.8 1.1 2.1 -0.6 -0.9 1.4
Rheumatoid Arthritis 0.1 0.1 0.2 0.4 -0.3 -0.4
Schizophrenia (2014) 0.3 0.7 1.7 1.3 0.4 -0.4
Triglycerides 0.5 0.8 1.2 1.1 -1.0 0.6
Type 2 Diabetes (T2D) (2012) 0.3 0.4 0.8 -0.5 -0.4 0.9
Ulcerative Colitis 2.0 2.8 6.0 -0.7 -1.4 2.4
Blood Eosinophil Count 0.2 1.3 2.0 -1.3 0.2 1.4
Blood Platelet Count 0.1 1.3 2.7 -0.9 1.6 0.7
Blood Red Count 0.3 3.2 4.8 -0.6 -2.1 2.2
Blood White Count 0.4 2.7 4.7 -2.2 0.7 1.7
Heel T-Score 2.2 17.6 51.8 1.0 0.1 -7.2
BMI 0.1 0.4 0.7 -0.4 -0.8 0.6
Height 4.6 89.2 231.0 0.1 6.0 -15.2
Waist Hip Ratio (WHR) 1.4 6.4 16.2 -1.7 4.0 0.2
Systolic Blood Pressure 0.4 2.1 4.1 0.4 -2.0 1.5
Smoking Status 1.2 2.8 7.7 -0.1 0.7 2.8
Allergy or Eczema 0.2 0.5 1.6 -1.3 -0.0 0.1
Cardiovascular Disease 0.3 1.1 2.8 0.2 -1.7 0.6
Hypothyroidism (self reported) 1.0 2.2 2.7 -1.6 -1.5 1.3
Respiratory disease 0.8 1.8 2.8 -1.1 1.2 1.7
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.4 -1.2 -1.1 0.8
Lung FEV1/FVC ratio 0.1 0.3 0.5 -0.5 0.7 0.3
Lung FVC 0.0 0.0 0.1 0.1 -0.3 -0.1
Neuroticism 1.1 2.6 3.9 -0.3 -2.0 1.9
Chronotype (morning person) 1.1 2.6 6.6 0.4 1.0 -2.6
Hair Pigment 0.5 12.9 28.7 1.6 5.4 -2.7
Tanning 0.1 1.8 5.2 0.0 -2.3 0.4
Hand grip strength (left) 4.6 12.0 22.9 3.6 -0.6 -4.8
Number of treatments/medications taken 1.2 2.2 5.3 -1.1 -0.4 2.3
Average weekly spirits intake 1.1 1.3 1.9 -0.6 -1.3 1.4
Sensitivity / hurt feelings 0.1 0.1 0.2 0.4 -0.3 0.2
Frequency of depressed mood in last 2 weeks 0.1 0.1 0.3 -0.5 0.0 -0.2
Hearing difficulty/problems: Yes 1.6 2.5 3.9 -1.7 2.0 0.8
Relative age of first facial hair 0.7 1.5 2.7 1.6 1.0 1.0
Other serious medical condition/disability diagnosed by doctor 2.0 2.6 6.0 -1.3 0.2 2.5
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.5 -0.1 0.7 1.6
Ever had hysterectomy (womb removed) 1.7 2.0 3.6 0.4 -1.5 1.9
Systolic blood pressure, automated reading 0.4 1.3 2.2 0.2 -1.5 1.2
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 1.0 -0.9 -1.0 1.0
Angina 1.4 1.9 3.4 -1.3 0.7 1.8
Medication for hormone replacement therapy 0.2 0.2 0.4 0.3 -0.2 0.6
Vitamin and mineral supplements 2.0 2.8 4.2 -2.1 1.8 0.9
Supplements: Zinc 1.0 1.0 1.7 1.3 0.1 -1.2
Medication: Co-codamol 1.2 1.3 3.4 -0.7 0.3 1.9
Medication: Metformin 1.1 1.6 4.1 -2.0 -0.2 0.8
Diabetes (father) 0.0 0.0 0.1 0.1 -0.0 -0.3
Diabetes (mother) 1.2 1.6 2.9 1.7 -0.6 -1.2
Severe depression (siblings) 0.8 0.9 2.0 -0.2 -0.8 -1.4
Pack years adult smoking proportion 0.8 1.3 2.6 -1.6 1.1 0.0
Impedance of leg (right) 0.4 2.1 3.1 -1.8 1.2 1.2
Leg fat-free mass (left) 2.0 10.8 31.4 1.0 0.3 -5.6
Trunk fat percentage 0.2 1.0 2.3 -1.5 0.5 0.6
Hand grip strength (right) 4.9 13.4 31.5 2.9 -0.4 -5.6
Townsend deprivation index at recruitment 0.8 1.1 1.6 -1.0 0.9 1.3
Current tobacco smoking 1.8 3.0 6.2 -1.3 0.9 2.5
Average weekly fortified wine intake 0.6 0.7 1.2 -0.3 -1.1 -0.9
Maternal smoking around birth 0.5 0.7 1.0 0.9 -0.5 1.0
Fed-up feelings 0.9 1.7 4.8 0.3 -0.4 2.2
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 2.0 -1.0 -0.7 1.4
Relative age voice broke 0.1 0.1 0.3 0.5 0.3 0.2
Taking other prescription medications 1.4 2.1 5.5 -0.4 -0.8 2.3
Age when periods started (menarche) 0.4 1.1 1.5 -1.2 1.2 0.6
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.2 -1.0 -0.7 1.5
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 5.8 -0.2 0.8 -2.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.9 0.9 0.7 -0.5
Qualifications: CSEs or equivalent 1.1 1.5 3.4 0.8 1.9 -0.6
Serious illness, injury or assault to yourself 0.6 0.8 2.0 0.1 -0.6 1.4
High blood pressure 0.4 1.1 1.7 -0.7 -1.0 1.3
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.6 -1.3 -0.5 0.3
Multivitamins +/- minerals 3.1 3.9 5.7 2.4 -1.7 -1.8
Stomach or abdominal pain in last month 0.4 0.5 1.0 -1.0 -0.0 0.7
Supplements: Glucosamine 1.2 1.6 3.5 1.9 -0.7 -0.8
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 0.6 0.6 -0.2 -0.8
Medication: Atenolol 0.7 0.9 2.5 -0.5 -0.1 1.6
Medication: Levothyroxine sodium 1.6 2.7 3.8 -1.8 -1.0 1.9
Sitting height 4.4 30.9 85.6 1.8 2.0 -9.2
Chronic bronchitis/emphysema (father) 0.5 0.5 1.0 -0.6 1.0 0.5
High blood pressure (mother) 0.7 1.0 1.8 1.0 0.3 -1.4
Body mass index (BMI) 0.3 1.3 2.0 0.1 -1.4 1.4
Impedance of leg (left) 0.4 2.1 3.3 -1.8 1.8 0.3
Leg predicted mass (left) 2.1 11.0 31.9 1.0 0.4 -5.7
Trunk fat mass 0.3 1.3 2.4 -1.0 0.7 -1.6
Waist circumference 0.2 0.8 1.5 -1.2 0.3 0.8
Number of incorrect matches in round 0.5 0.9 2.6 0.0 1.6 0.1
Past tobacco smoking 0.1 0.2 0.4 0.0 -0.2 -0.6
Alcohol usually taken with meals 0.4 0.7 1.6 0.1 0.6 -1.3
Nervous feelings 1.7 3.1 4.7 -0.6 -2.2 2.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 1.9 -0.9 -0.2 1.4
Hearing difficulty/problems with background noise 0.3 0.5 0.9 -0.8 -0.3 0.9
Hair/balding pattern: Pattern 2 17.3 22.0 49.7 2.7 -7.0 3.0
Had menopause 0.5 0.7 1.3 1.1 -0.5 0.6
Had other major operations 1.9 2.4 5.3 -0.3 -2.3 1.3
Forced vital capacity (FVC) 2.8 10.8 29.2 0.7 1.6 -5.4
Heel bone mineral density (BMD) T-score, automated (right) 1.1 2.5 6.2 0.2 1.2 -2.5
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.6 -0.5 -0.3 0.8
Qualifications: None of the above 1.3 2.8 7.2 -1.0 -0.6 2.7
Financial difficulties in last 2 years 0.9 1.2 1.9 -1.4 1.2 0.4
Mouth/teeth dental problems 1.4 2.2 3.7 -0.1 1.7 -1.9
Heart attack 1.5 1.9 5.2 -0.7 -0.3 2.3
Allergy 0.3 0.7 1.1 1.1 0.6 -0.9
Pain all over the body in last month 0.3 0.4 0.9 0.1 0.4 -1.0
Diabetes (self-reported) 0.8 1.3 3.5 -0.1 -1.9 0.6
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.3 0.1 -1.5 1.0
Medication: Ramipril 1.2 1.6 4.2 0.7 -2.0 -0.1
Medication: Simvastatin 0.4 0.6 1.8 0.1 -0.3 1.4
Fluid intelligence score 0.8 1.6 4.6 0.3 -2.1 -0.3
Illnesses of siblings 0.7 1.0 2.1 0.3 0.9 -1.4
Neuroticism score 1.5 3.2 5.9 -0.1 -2.4 1.9
Weight 1.0 5.1 15.4 0.3 0.1 -3.9
Impedance of arm (right) 0.6 2.7 4.6 -2.2 1.8 0.6
Arm fat percentage (right) 0.3 1.1 2.7 -0.7 -0.4 1.6
Trunk fat-free mass 3.5 20.0 57.0 1.6 0.5 -7.5
Hip circumference 0.2 0.9 2.3 0.1 -1.5 -0.4
Time employed in main current job 0.2 0.3 0.8 0.9 0.3 0.1
Alcohol intake versus 10 years previously 1.4 2.1 2.5 -1.4 1.6 1.2
Father’s age at death 1.6 2.1 5.6 0.2 -0.8 -2.4
Worrier / anxious feelings 0.8 1.4 4.0 -0.1 -2.0 0.5
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 8.8 -3.0 1.4 1.5
Falls in the last year 1.4 1.8 4.0 -2.0 0.5 1.1
Hair/balding pattern: Pattern 3 1.1 1.6 2.3 -0.8 1.4 -1.5
Number of live births 1.0 1.5 3.8 1.9 -0.2 0.8
Forced expiratory volume in 1-second (FEV1) 2.7 9.0 25.0 0.9 1.1 -5.0
Pulse rate 0.6 1.0 2.2 1.5 -0.1 -0.9
Happiness 0.4 0.5 0.9 -0.9 0.5 0.7
Noisy workplace 2.0 2.4 3.3 -1.8 1.6 1.2
Qualifications: A levels/AS levels or equivalent 1.1 2.5 6.3 0.8 -0.7 -2.5
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 1.4 1.2 -0.6 -1.0
Mouth/teeth dental problems: Dentures 1.3 2.2 3.0 0.9 -1.7 1.7
Asthma 0.8 1.7 4.5 -0.6 0.4 2.1
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.7 1.8 0.4 -0.2 1.4
Medication: Cholesterol lowering 1.7 2.6 7.2 -0.3 -0.7 2.7
Depression (self-reported) 1.1 1.3 2.2 -1.5 -1.2 0.6
Medication: Lansoprazole 3.4 3.9 5.9 -1.9 1.5 2.4
Prospective memory result 1.6 2.0 4.0 -1.1 -0.8 2.0
Lung cancer (father) 0.3 0.3 0.7 -0.5 0.8 -0.1
Illnesses of mother 1.2 1.4 2.6 -1.3 0.1 1.6
Forced expiratory volume in 1-second (FEV1), Best measure 2.6 8.4 23.0 0.5 1.4 -4.8
Pulse wave Arterial Stiffness index 0.3 0.4 1.0 0.3 0.1 -1.0
Impedance of arm (left) 0.3 1.6 3.1 -1.3 1.8 -0.2
Arm fat mass (right) 0.0 0.1 0.2 -0.1 -0.4 -0.5
Trunk predicted mass 3.5 19.8 56.2 1.7 0.5 -7.5
Standing height 4.9 48.8 136.9 0.4 3.1 -11.7
Length of working week for main job 1.0 1.1 3.1 -0.3 1.7 0.2
Exposure to tobacco smoke at home 0.7 0.7 1.6 -0.6 1.3 0.6
Breastfed as a baby 0.8 1.0 2.5 1.6 0.3 -0.7
Tense / ‘highly strung’ 1.4 2.3 4.8 0.3 -2.2 1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.1 0.1 -0.4 -0.3 -0.1
Hair/balding pattern: Pattern 4 2.0 4.9 11.6 0.1 -1.8 -3.4
Birth weight of first child 2.4 4.3 10.3 1.4 0.8 -3.2
Peak expiratory flow (PEF) 1.8 4.3 10.4 0.8 1.4 -3.2
Pulse wave reflection index 0.1 0.2 0.4 -0.4 0.0 -0.6
Ever highly irritable/argumentative for 2 days 0.5 0.5 0.8 -0.9 0.8 0.5
Loud music exposure frequency 0.1 0.1 0.2 0.1 0.0 -0.5
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 2.1 0.5 0.3 -1.4
Mouth/teeth dental problems: Bleeding gums 1.6 2.1 3.4 -1.6 0.4 1.8
Blood clot in the leg (DVT) 0.2 0.3 0.5 -0.7 0.2 0.7
Medication: Paracetamol 0.4 0.7 1.6 -0.6 -0.3 1.3
Headache pain in last month 0.1 0.1 0.1 -0.4 0.3 -0.4
Medication for cholesterol, blood pressure or diabetes 2.5 4.1 9.1 0.5 1.7 -3.0
Glaucoma (self-reported) 0.6 0.8 1.3 0.4 1.1 -0.9
Gout (self-reported) 0.0 0.0 0.0 0.1 -0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 1.9 3.7 5.0 -1.7 -1.9 2.2
Medication: Amlodipine 0.5 0.7 1.4 -0.8 -0.1 1.2
Medication: Ventolin 100micrograms inhaler 1.0 1.3 3.3 -0.7 1.8 0.0
Birth weight 3.0 6.5 9.4 -3.1 2.4 -2.1
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.7 0.1 -0.8 -0.6
High blood pressure (siblings) 0.6 0.8 1.5 -0.5 -0.9 1.2
Forced vital capacity (FVC), Best measure 3.3 12.1 31.2 0.4 2.2 -5.6
Body fat percentage 0.3 1.2 2.1 -1.4 0.3 1.2
Leg fat percentage (right) 0.9 3.1 7.3 -1.2 -0.7 2.7
Arm fat-free mass (right) 2.8 14.2 40.4 1.4 0.3 -6.4
Exposure to tobacco smoke outside home 0.4 0.5 0.9 -0.7 0.9 0.4
Comparative body size at age 10 1.2 3.3 7.6 -2.8 1.3 -0.8
Number of full brothers 0.6 0.7 1.2 1.1 -0.0 1.0
Worry too long after embarrassment 1.1 1.9 3.7 1.9 -1.0 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.5 0.6 1.0 -1.0 -0.1 0.9
Wheeze or whistling in the chest in last year 2.8 5.1 8.4 -1.9 1.8 2.9
Number of children fathered 1.9 2.2 4.2 -1.3 2.0 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.3 0.6 0.6 -0.5
Age at first live birth 0.6 1.1 1.7 1.2 -0.5 -1.3
Pulse wave peak to peak time 0.0 0.0 0.0 -0.1 -0.0 0.1
Health satisfaction 0.4 0.6 1.1 -0.6 -0.4 1.1
Shortness of breath walking on level ground 0.2 0.2 0.3 0.5 0.4 0.3
Qualifications: College or University degree 2.1 6.6 11.2 1.7 -2.4 -3.3
Eye problems/disorders: None of the above 0.4 0.5 1.1 0.4 -0.5 -1.0
Mouth/teeth dental problems: Loose teeth 1.1 1.3 2.2 1.3 -1.5 0.3
Emphysema/chronic bronchitis 0.3 0.4 0.8 -0.6 0.9 -0.2
Medication for pain relief, constipation, heartburn 1.7 2.8 6.2 1.3 -0.7 -2.5
Neck or shoulder pain in last month 1.2 1.7 3.1 -1.3 0.5 1.8
Medication: Blood pressure 1.7 2.9 6.3 -0.8 -1.4 2.5
Angina (self-reported) 1.7 2.2 3.5 -1.5 0.9 1.9
Migraine (self-reported) 1.5 1.9 3.5 -1.2 1.9 -0.9
Medication: Ibuprofen 0.5 0.5 0.8 -0.2 0.9 0.9
Medication: Allopurinol 0.1 0.2 0.5 0.2 -0.7 -0.1
Medication: Omeprazole 0.5 0.6 0.8 -0.9 0.7 0.6
Medication: Seretide 50 evohaler 5.3 6.1 9.9 -3.1 2.6 1.2
Mean time to correctly identify matches 0.8 1.5 2.3 -1.5 1.2 0.8
Heart disease (mother) 0.5 0.6 1.3 1.1 -0.2 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.1 0.2 0.3 0.5 -0.5 -0.0
Whole body fat mass 0.2 0.7 1.2 -0.9 0.5 -1.1
Leg fat mass (right) 0.0 0.2 0.5 -0.7 -0.0 -0.1
Arm predicted mass (right) 3.0 15.2 43.6 1.3 0.5 -6.6
Pulse rate, automated reading 0.2 0.7 2.0 -0.2 1.4 -0.4
Alcohol intake frequency. 0.1 0.2 0.3 -0.4 -0.0 0.6
Comparative height size at age 10 2.3 12.9 34.8 -1.2 1.5 -5.9
Number of full sisters 0.6 0.8 1.8 1.3 0.7 0.1
Suffer from ‘nerves’ 0.4 0.6 1.2 -0.4 -1.1 0.7
Overall health rating 1.3 2.8 6.7 -0.9 -0.9 2.6
Chest pain or discomfort 0.8 1.1 2.5 -1.6 0.9 -0.1
Had major operations 2.6 3.1 5.3 1.0 -1.7 2.3
Age at last live birth 0.9 1.3 1.5 1.2 -1.1 -1.1
Family relationship satisfaction 0.2 0.3 0.5 0.2 -0.7 0.5
Leg pain on walking 1.4 1.7 3.9 -2.0 1.1 0.3
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.5 1.4 1.2 -0.0 0.4
Commuting to job workplace: Car/motor vehicle 0.4 0.5 1.4 -1.2 0.2 -0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.7 -0.7 0.5 -1.3
Medication: Aspirin 1.8 2.4 4.4 -1.1 1.2 2.1
Supplements: Vitamin C 0.4 0.5 0.8 -0.1 -0.9 0.9
Knee pain experienced in last month 1.5 2.3 5.4 0.6 -1.1 2.3
Hypertension (Self-reported) 0.5 1.3 1.9 -0.6 -1.4 1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.9 1.1 1.6 -0.7 -1.3 1.0
Illnesses of father: Heart disease 1.3 1.7 3.8 1.9 -0.2 -1.2
Illnesses of siblings: Diabetes 3.0 3.7 7.0 -0.8 -1.8 2.6
Smoking status: Previous 0.5 0.7 1.8 1.3 -0.5 -0.3
Forced expiratory volume in 1-second (FEV1), predicted 3.3 6.9 17.4 0.7 1.7 -4.2
Whole body fat-free mass 3.1 17.4 50.0 1.5 0.5 -7.1
Leg fat-free mass (right) 2.7 14.3 40.8 1.3 0.5 -6.4
Arm fat percentage (left) 0.1 0.5 1.1 -0.3 -0.5 1.0
Average weekly red wine intake 0.4 0.6 1.6 -0.1 -0.2 -1.3
Handedness (chirality/laterality): Left-handed 2.2 2.6 4.8 -2.2 1.5 0.8
Mood swings 4.3 7.7 16.1 -1.4 -2.2 4.0
Loneliness, isolation 0.2 0.2 0.3 -0.6 0.6 -0.1
Long-standing illness, disability or infirmity 4.1 6.2 15.2 -1.6 -0.9 3.9
Ever had bowel cancer screening 3.0 3.5 5.7 -2.0 2.4 1.0
Diabetes diagnosed by doctor 1.1 1.9 3.4 -1.4 -0.6 1.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.0 0.1 1.4 -0.6
Friendships satisfaction 0.1 0.1 0.3 0.5 0.1 -0.0
Qualifications: nursing, teaching 4.5 7.0 20.5 -0.1 0.7 -4.5
Commuting to job workplace: Walk 1.0 1.0 1.6 0.7 1.1 -1.2
Eye problems/disorders: Cataract 0.4 0.4 0.7 0.8 0.3 0.7
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.3 -0.5 -0.3
Medication for cholesterol 0.1 0.2 0.6 -0.3 -0.2 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 1.1 0.2 -0.7 1.1
Back pain experienced in last month 3.2 4.6 9.9 -3.2 0.9 1.8
Mineral and other dietary supplements 0.6 0.8 1.5 -0.8 1.2 0.3
Breast cancer (self-reported) 1.2 1.4 4.1 0.2 -0.2 2.0
Asthma (self-reported) 0.8 1.7 3.9 -0.8 0.6 2.0
Osteoporosis (self-reported) 1.3 1.6 2.4 -1.5 -0.9 1.3
Osteoarthritis (self-reported) 3.6 4.6 9.7 -1.2 -3.1 1.6
Medication: Aspirin 1.6 2.0 3.7 -1.3 0.9 1.9
Medication: Gliclazide 0.4 0.5 1.2 -1.1 0.4 -0.3
Illnesses of father: None of the above (group 1) 0.8 0.9 2.5 -1.6 0.5 0.1
Smoking status: Current 2.2 3.5 7.5 -1.5 0.9 2.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 4.0 0.3 2.0 -1.6
Whole body water mass 3.0 17.2 49.0 1.5 0.4 -7.0
Leg predicted mass (right) 2.7 14.4 41.2 1.3 0.4 -6.4
Arm fat mass (left) 0.1 0.3 0.6 0.0 -0.4 -0.8
Number of self-reported non-cancer illnesses 3.8 6.6 15.1 -1.7 -1.4 3.9
Average weekly champagne plus white wine intake 3.0 4.1 11.7 0.7 -0.1 -3.4
Miserableness 1.1 1.9 4.4 -1.0 -0.4 2.1
Guilty feelings 0.5 0.8 1.4 -0.2 -1.2 -1.0
Wears glasses or contact lenses 0.4 0.5 0.8 0.8 0.9 -0.0
Ever taken oral contraceptive pill 1.4 1.6 4.7 0.1 2.2 -0.1
Hearing aid user 2.0 2.3 4.1 1.7 -0.2 2.0
Mother’s age at death 0.3 0.3 0.3 -0.6 0.6 -0.6
Financial situation satisfaction 0.9 1.1 1.8 -1.0 1.4 0.6
Tinnitus: Yes, now most or all of the time 0.7 0.8 1.6 0.6 1.2 -0.7
Commuting to job workplace: Public transport 0.5 0.6 1.1 1.1 -0.5 -0.7
Eye problems/disorders: Glaucoma 0.9 1.0 2.1 -0.9 1.5 -0.4
Medication: Blood pressure 0.3 0.6 0.9 0.9 -1.0 -0.4
Pain type(s) experienced in last month: Hip pain 2.2 2.8 4.9 -0.2 -2.2 1.8
Supplements: Fish oil (including cod liver oil) 1.5 1.9 5.0 0.4 -2.2 0.8
High cholesterol (Self-reported) 0.4 0.7 1.2 0.3 -0.9 1.1
Medication: Bendroflumethiazide 0.0 0.0 0.0 0.2 0.0 0.1
Medication: Paracetamol 0.9 1.4 2.4 -1.5 0.6 1.1
Medication: Lisinopril 0.3 0.3 0.4 0.6 -0.6 -0.5
Medication: Atorvastatin 1.9 2.3 3.8 -1.7 -0.6 1.9
Illnesses of father: High blood pressure 0.1 0.2 0.3 -0.3 -0.4 -0.6
Alcohol drinker status: Never 0.3 0.4 1.0 0.2 -1.0 -0.3
Ever smoked 0.5 0.9 1.4 -1.2 1.1 0.3
Basal metabolic rate 2.6 14.4 41.5 1.3 0.3 -6.4
Leg fat percentage (left) 0.6 2.0 4.1 -1.3 -0.5 2.0
Arm fat-free mass (left) 2.6 13.1 36.8 1.5 0.1 -6.1
Number of operations (self-reported) 3.2 4.7 7.9 1.2 -2.8 2.2
Average weekly beer plus cider intake 0.4 0.6 1.1 0.3 0.7 1.0
Irritability 1.6 2.7 4.7 -0.6 -1.7 2.2
Risk taking 0.4 0.6 0.8 0.3 0.9 -0.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.2 -0.2 0.6
Fractured/broken bones in last 5 years 0.3 0.4 0.7 0.6 0.4 0.8
Age started oral contraceptive pill 0.4 0.5 0.8 0.9 -0.5 -0.7
Diastolic blood pressure, automated reading 0.5 1.6 3.1 1.7 -1.3 0.5
Ever depressed for a whole week 0.5 0.7 1.4 0.6 -0.5 1.2
Unable to work because of sickness or disability 2.0 2.6 7.2 -0.4 -0.6 2.7
Commuting to job workplace: Cycle 0.4 0.5 0.8 -0.9 -0.8 -0.2
Myopia 1.0 1.5 3.7 0.0 0.8 -1.9
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.7 0.4 1.1 -1.6
Cholesterol lowering medication 0.1 0.1 0.2 0.3 -0.4 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.8 -0.9 0.5 0.3
Pain experienced in last month 0.8 1.4 2.3 1.3 -0.3 -1.5
Supplements: Calcium 0.2 0.3 0.6 0.1 0.5 0.8
Basal cell carcinoma (self-reported) 0.5 0.6 1.8 0.0 1.3 -0.1
Heart attack/myocardial infarction (self-reported) 1.2 1.6 4.1 -0.8 -0.3 2.0
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.7 -0.9 0.4 0.6
Heart disease (siblings) 0.7 0.9 2.3 0.1 -0.7 1.5
Alcohol drinker status: Previous 0.8 0.9 1.9 -1.4 0.3 0.7
Pack years of smoking 1.4 2.0 3.6 -1.9 1.5 -0.1
Impedance of whole body 0.4 2.0 3.4 -1.6 1.9 0.3
Leg fat mass (left) 0.1 0.3 0.4 -0.7 -0.1 -0.6
Arm predicted mass (left) 2.2 11.3 31.9 1.4 0.0 -5.7