[Hub]/) : Traits : Arm fat-free mass (right) : ← →

chr5:129,797,129-132,839,137

Best TWAS P=9.86e-22 · Best GWAS P=4.4e-16 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
12	GTEx	Artery Tibial	HINT1	0.11	0.04	enet	18	0.06	1.0e-05	-7.5	-9.6	9.9e-22	-0.55	0.06	0.90	TRUE
75	YFS	Blood	SLC22A5	0.38	0.36	bslmm	430	0.37	3.0e-128	7.9	-8.7	4.5e-18	-0.87	0.03	0.97	TRUE
76	The Cancer Genome Atlas	Breast Invasive Carcinoma	P4HA2	0.03	0.02	blup	47	0.03	3.1e-06	8.1	7.5	4.6e-14	0.86	0.00	1.00	TRUE
50	GTEx	Skin Not Sun Exposed Suprapubic	PDLIM4	0.13	0.08	lasso	2	0.06	2.6e-04	7.9	-7.3	2.2e-13	-0.84	0.06	0.89	TRUE
82	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A5	0.06	0.05	blup	93	0.08	1.2e-09	-6.5	-6.7	2.4e-11	-0.76	0.07	0.93	TRUE
19	GTEx	Brain Nucleus accumbens basal ganglia	AC034220.3	0.24	0.24	enet	34	0.24	3.7e-07	-6.5	6.5	5.6e-11	0.71	0.85	0.09	TRUE
81	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SLC22A4	0.02	0.02	lasso	1	0.02	3.0e-03	-5.8	-5.8	5.9e-09	-0.58	0.12	0.54	TRUE
2	GTEx	Adipose Subcutaneous	HINT1	0.10	0.07	enet	16	0.06	8.8e-06	-7.9	-9.5	2.2e-21	-0.39	0.04	0.95	FALSE
8	GTEx	Artery Aorta	HINT1	0.07	0.07	enet	8	0.06	4.7e-04	-7.6	-8.6	8.9e-18	-0.34	0.08	0.56	FALSE
11	GTEx	Artery Tibial	P4HA2	0.12	0.15	lasso	6	0.14	3.2e-11	8.1	8.5	1.7e-17	0.98	0.01	0.99	FALSE
24	GTEx	Cells Transformed fibroblasts	HINT1	0.10	0.06	lasso	2	0.05	2.1e-04	-7.5	-8.2	3.3e-16	-0.35	0.05	0.94	FALSE
54	GTEx	Spleen	SLC22A5	0.26	0.28	lasso	4	0.28	6.6e-08	7.9	8.1	5.1e-16	0.88	0.04	0.88	FALSE
44	GTEx	Nerve Tibial	P4HA2-AS1	0.14	0.05	lasso	8	0.08	3.8e-06	7.2	8.1	6.4e-16	0.89	0.02	0.97	FALSE
57	GTEx	Testis	P4HA2	0.14	0.13	lasso	5	0.11	1.4e-05	8.0	8.1	7.1e-16	0.95	0.02	0.98	FALSE
10	GTEx	Artery Aorta	P4HA2-AS1	0.08	0.03	lasso	3	0.01	6.6e-02	7.9	8.0	9.1e-16	0.99	0.02	0.95	FALSE
7	GTEx	Artery Aorta	P4HA2	0.12	0.14	lasso	2	0.11	1.2e-06	8.0	8.0	1.2e-15	0.96	0.01	0.99	FALSE
31	GTEx	Esophagus Mucosa	SLC22A5	0.16	0.16	enet	8	0.16	6.3e-11	7.9	-8.0	1.5e-15	-0.94	0.02	0.98	FALSE
52	GTEx	Skin Sun Exposed Lower leg	PDLIM4	0.09	0.08	lasso	8	0.09	1.0e-07	8.0	-8.0	1.6e-15	-0.91	0.02	0.98	FALSE
68	METSIM	Adipose	P4HA2	0.09	0.08	lasso	12	0.09	2.4e-13	8.1	8.0	1.6e-15	0.87	0.01	0.99	FALSE
14	GTEx	Artery Tibial	P4HA2-AS1	0.10	0.09	lasso	4	0.11	1.0e-08	8.1	7.9	2.5e-15	0.95	0.01	0.99	FALSE
30	GTEx	Esophagus Mucosa	P4HA2	0.23	0.10	lasso	6	0.14	6.1e-10	8.0	7.9	2.5e-15	0.93	0.01	0.99	FALSE
70	METSIM	Adipose	SLC22A5	0.05	0.08	lasso	1	0.08	1.0e-11	7.9	-7.9	2.6e-15	-0.89	0.05	0.95	FALSE
65	GTEx	Whole Blood	SLC22A5	0.09	0.12	lasso	2	0.10	1.7e-09	7.9	-7.9	2.7e-15	-0.89	0.03	0.97	FALSE
87	The Cancer Genome Atlas	Lung Adenocarcinoma	LYRM7	0.03	0.01	enet	10	0.02	7.5e-04	-5.6	7.9	3.9e-15	0.37	0.01	0.90	FALSE
96	The Cancer Genome Atlas	Thyroid Carcinoma	P4HA2	0.21	0.35	enet	10	0.35	4.7e-35	8.1	7.9	3.9e-15	0.98	0.00	1.00	FALSE
73	ROSMAP	Brain Pre-frontal Cortex	SLC22A4	0.03	0.05	lasso	2	0.04	1.2e-05	-7.5	-7.8	4.7e-15	-0.73	0.35	0.59	FALSE
53	GTEx	Skin Sun Exposed Lower leg	SLC22A5	0.25	0.21	lasso	3	0.20	1.4e-16	7.7	-7.8	6.7e-15	-0.89	0.07	0.93	FALSE
38	GTEx	Lung	SLC22A5	0.10	0.15	enet	11	0.13	3.4e-10	7.9	-7.7	1.4e-14	-0.93	0.04	0.96	FALSE
33	GTEx	Esophagus Mucosa	P4HA2-AS1	0.09	0.06	lasso	6	0.08	5.4e-06	8.0	7.7	1.6e-14	0.96	0.03	0.97	FALSE
18	GTEx	Brain Hippocampus	AC034220.3	0.21	0.15	lasso	14	0.18	5.8e-05	-6.7	7.5	8.8e-14	0.85	0.07	0.87	FALSE
9	GTEx	Artery Aorta	AC034220.3	0.08	0.06	lasso	3	0.05	1.1e-03	-6.5	7.4	1.1e-13	0.75	0.43	0.34	FALSE
59	GTEx	Testis	RAPGEF6	0.50	0.35	lasso	4	0.32	6.5e-15	-7.2	-7.4	1.1e-13	-0.32	0.88	0.12	FALSE
41	GTEx	Nerve Tibial	P4HA2	0.19	0.12	enet	26	0.14	6.2e-10	-6.4	7.4	1.3e-13	0.86	0.01	0.99	FALSE
66	GTEx	Whole Blood	AC034220.3	0.08	0.05	enet	31	0.06	4.0e-06	7.7	-7.3	2.1e-13	-0.79	0.08	0.91	FALSE
63	GTEx	Thyroid	P4HA2-AS1	0.08	0.06	enet	14	0.05	1.6e-04	8.1	7.3	2.3e-13	0.91	0.01	0.99	FALSE
61	GTEx	Thyroid	P4HA2	0.08	0.07	enet	9	0.06	3.5e-05	8.1	7.3	3.0e-13	0.98	0.01	0.99	FALSE
25	GTEx	Cells Transformed fibroblasts	SLC22A5	0.32	0.28	lasso	7	0.35	1.6e-27	-6.3	-7.2	6.0e-13	-0.84	0.38	0.62	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	SLC22A5	0.13	0.05	lasso	8	0.05	8.3e-04	-6.5	-7.2	6.1e-13	-0.82	0.16	0.84	FALSE
69	METSIM	Adipose	PDLIM4	0.05	0.04	lasso	4	0.02	2.8e-04	7.3	-7.2	8.0e-13	-0.87	0.70	0.25	FALSE
93	The Cancer Genome Atlas	Thyroid Carcinoma	C5orf56	0.06	0.04	blup	98	0.03	1.3e-03	-4.0	7.1	1.0e-12	0.55	0.79	0.12	FALSE
62	GTEx	Thyroid	PDLIM4	0.05	0.02	enet	5	0.01	3.1e-02	7.2	-7.1	1.3e-12	-0.90	0.07	0.84	FALSE
35	GTEx	Heart Atrial Appendage	AC034220.3	0.16	0.09	enet	17	0.18	1.7e-08	-6.4	7.1	1.6e-12	0.78	0.55	0.45	FALSE
58	GTEx	Testis	PDLIM4	0.15	0.07	enet	8	0.05	2.5e-03	-6.7	7.1	1.7e-12	0.71	0.24	0.15	FALSE
36	GTEx	Heart Left Ventricle	AC034220.3	0.25	0.22	lasso	6	0.25	8.6e-14	-6.5	7.0	1.8e-12	0.71	0.97	0.03	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	SLC22A5	0.37	0.05	lasso	13	0.10	2.8e-04	7.9	-7.0	2.3e-12	-0.77	0.06	0.88	FALSE
91	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A4	0.09	0.07	blup	108	0.09	3.0e-09	-6.4	-7.0	3.2e-12	-0.78	0.14	0.86	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	HINT1	0.07	0.04	lasso	2	0.01	1.8e-02	-7.0	-7.0	3.3e-12	-0.32	0.00	0.98	FALSE
28	GTEx	Colon Transverse	AC034220.3	0.30	0.15	lasso	3	0.11	8.4e-06	-6.5	6.9	5.1e-12	0.73	0.91	0.05	FALSE
64	GTEx	Whole Blood	SLC22A4	0.07	0.05	enet	16	0.05	4.6e-05	-6.3	-6.9	6.9e-12	-0.71	0.14	0.78	FALSE
40	GTEx	Muscle Skeletal	MIR3936	0.04	0.01	lasso	4	0.00	9.9e-02	-5.3	6.8	1.0e-11	0.83	0.10	0.59	FALSE
15	GTEx	Brain Caudate basal ganglia	AC034220.3	0.41	0.45	enet	19	0.46	8.8e-15	-6.4	6.8	1.2e-11	0.73	0.97	0.03	FALSE
13	GTEx	Artery Tibial	SLC22A5	0.18	0.12	enet	8	0.12	2.5e-09	7.7	-6.7	1.9e-11	-0.82	0.07	0.93	FALSE
89	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SLC22A5	0.05	0.03	blup	93	0.05	1.9e-06	-5.6	-6.7	2.2e-11	-0.74	0.04	0.96	FALSE
39	GTEx	Muscle Skeletal	AC034220.3	0.27	0.23	lasso	9	0.24	9.1e-24	-6.4	6.7	2.9e-11	0.77	1.00	0.00	FALSE
79	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A5	0.05	0.07	enet	11	0.09	5.3e-17	-5.6	-6.7	3.0e-11	-0.68	1.00	0.00	FALSE
43	GTEx	Nerve Tibial	AC034220.3	0.15	0.11	lasso	5	0.10	1.9e-07	-6.4	6.6	3.5e-11	0.71	0.99	0.01	FALSE
56	GTEx	Stomach	AC034220.3	0.17	0.15	enet	21	0.16	4.2e-08	-5.6	6.6	3.5e-11	0.68	0.99	0.01	FALSE
71	NTR	Blood	SLC22A4	0.02	0.00	blup	423	0.01	5.2e-04	3.7	-6.6	5.0e-11	-0.67	0.22	0.75	FALSE
88	The Cancer Genome Atlas	Lung Adenocarcinoma	SLC22A5	0.06	0.03	lasso	4	0.02	9.3e-04	-6.3	-6.6	5.2e-11	-0.68	0.06	0.73	FALSE
32	GTEx	Esophagus Mucosa	AC034220.3	0.08	0.03	lasso	3	0.05	4.7e-04	-6.7	6.5	5.6e-11	0.71	0.94	0.04	FALSE
86	The Cancer Genome Atlas	Brain Lower Grade Glioma	HINT1	0.06	0.03	enet	5	0.03	5.2e-04	-5.5	-6.5	6.3e-11	-0.25	0.08	0.41	FALSE
84	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC22A4	0.03	0.03	lasso	1	0.02	3.5e-03	-6.5	-6.5	7.1e-11	-0.71	0.35	0.26	FALSE
80	The Cancer Genome Atlas	Colon Adenocarcinoma	SLC22A5	0.08	0.04	blup	92	0.07	1.2e-04	-6.3	-6.5	7.3e-11	-0.75	0.03	0.91	FALSE
55	GTEx	Stomach	SLC22A5	0.09	0.04	lasso	4	0.01	9.0e-02	-5.7	-6.5	1.0e-10	-0.71	0.08	0.55	FALSE
27	GTEx	Colon Transverse	SLC22A5	0.12	0.07	enet	8	0.07	2.5e-04	7.9	-6.5	1.1e-10	-0.81	0.10	0.82	FALSE
4	GTEx	Adipose Subcutaneous	AC034220.3	0.11	0.11	lasso	10	0.09	4.8e-08	-6.4	6.4	1.2e-10	0.71	0.99	0.01	FALSE
6	GTEx	Adrenal Gland	AC034220.3	0.12	0.11	lasso	16	0.08	7.7e-04	-6.4	6.4	1.3e-10	0.71	0.66	0.13	FALSE
5	GTEx	Adipose Visceral Omentum	AC034220.3	0.10	0.09	lasso	7	0.08	7.3e-05	-6.4	6.4	1.7e-10	0.71	0.42	0.31	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	SEPT8	0.22	0.08	lasso	12	0.10	2.2e-04	-5.8	6.4	1.7e-10	0.61	0.36	0.47	FALSE
45	GTEx	Ovary	AC004041.2	0.21	-0.01	lasso	2	-0.01	7.7e-01	-4.9	6.4	1.8e-10	0.65	0.06	0.28	FALSE
60	GTEx	Testis	AC034220.3	0.15	0.12	lasso	9	0.12	4.4e-06	-6.4	6.4	1.8e-10	0.71	0.86	0.05	FALSE
78	The Cancer Genome Atlas	Breast Invasive Carcinoma	SLC22A4	0.05	0.01	enet	7	0.02	1.6e-05	7.9	-6.3	2.8e-10	-0.82	0.02	0.97	FALSE
97	The Cancer Genome Atlas	Thyroid Carcinoma	SLC22A5	0.03	0.02	lasso	1	0.01	2.6e-02	-6.3	-6.3	3.5e-10	-0.72	0.02	0.70	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	IRF1	0.05	0.02	blup	83	0.03	1.5e-03	5.4	6.2	4.0e-10	0.79	0.05	0.20	FALSE
26	GTEx	Colon Sigmoid	AC034220.3	0.18	0.11	lasso	12	0.06	3.7e-03	-6.7	6.2	4.5e-10	0.70	0.24	0.17	FALSE
16	GTEx	Brain Cortex	AC034220.3	0.43	0.39	lasso	15	0.17	2.4e-05	-6.4	6.2	5.1e-10	0.70	0.92	0.08	FALSE
83	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDLIM4	0.09	0.02	lasso	6	0.05	4.5e-06	-4.9	-6.2	5.2e-10	-0.69	0.24	0.56	FALSE
46	GTEx	Pancreas	P4HA2	0.22	0.21	lasso	13	0.20	5.3e-09	-4.8	6.2	5.3e-10	0.59	0.71	0.27	FALSE
48	GTEx	Pituitary	AC034220.3	0.25	0.22	lasso	12	0.18	3.1e-05	-5.5	6.2	5.8e-10	0.66	0.66	0.10	FALSE
3	GTEx	Adipose Subcutaneous	SLC22A5	0.05	0.04	lasso	4	0.04	4.2e-04	7.7	-6.2	6.8e-10	-0.83	0.04	0.93	FALSE
21	GTEx	Breast Mammary Tissue (Female)	SLC22A5	0.04	-0.01	lasso	3	0.01	1.3e-01	-4.0	-6.1	1.2e-09	-0.57	0.05	0.15	FALSE
20	GTEx	Breast Mammary Tissue	SLC22A5	0.10	0.02	enet	16	0.06	4.5e-04	7.9	-6.1	1.3e-09	-0.71	0.16	0.77	FALSE
90	The Cancer Genome Atlas	Prostate Adenocarcinoma	PDLIM4	0.32	0.36	enet	13	0.37	3.8e-40	-4.9	-6.1	1.3e-09	-0.77	1.00	0.00	FALSE
49	GTEx	Prostate	AC034220.3	0.38	0.37	lasso	5	0.37	3.0e-10	-6.5	6.0	2.3e-09	0.69	0.92	0.07	FALSE
72	ROSMAP	Brain Pre-frontal Cortex	PDLIM4	0.25	0.27	lasso	4	0.26	2.7e-33	-5.3	-6.0	2.7e-09	-0.75	1.00	0.00	FALSE
34	GTEx	Esophagus Muscularis	AC034220.3	0.12	0.08	enet	20	0.07	3.8e-05	-6.5	5.9	3.4e-09	0.64	0.81	0.10	FALSE
85	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SLC22A4	0.04	0.03	blup	108	0.01	7.1e-02	-5.6	-5.7	1.4e-08	-0.63	0.12	0.15	FALSE
47	GTEx	Pancreas	P4HA2-AS1	0.16	0.16	lasso	5	0.16	3.2e-07	-4.8	5.5	3.2e-08	0.51	0.57	0.34	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PDLIM4	0.11	0.18	lasso	5	0.18	8.0e-21	-5.2	-5.5	5.0e-08	-0.69	1.00	0.00	FALSE
23	GTEx	Cells Transformed fibroblasts	PDLIM4	0.08	0.09	lasso	1	0.07	6.4e-06	-5.3	-5.3	9.2e-08	-0.68	0.80	0.06	FALSE
17	GTEx	Brain Frontal Cortex BA9	AC034220.3	0.31	0.20	lasso	14	0.21	3.3e-06	-6.7	5.3	1.3e-07	0.65	0.62	0.24	FALSE
77	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDLIM4	0.05	0.05	lasso	4	0.05	9.0e-11	-5.3	-5.3	1.4e-07	-0.71	0.99	0.01	FALSE
74	YFS	Blood	CDC42SE2	0.14	0.05	lasso	9	0.07	3.1e-22	-7.2	5.2	1.5e-07	0.20	0.78	0.22	FALSE
37	GTEx	Liver	AC034220.3	0.30	0.16	lasso	6	0.16	3.9e-05	-6.4	5.2	1.6e-07	0.57	0.59	0.05	FALSE
67	GTEx	Whole Blood	AC116366.6	0.05	0.04	lasso	17	0.03	5.7e-04	-3.8	5.2	2.0e-07	0.50	0.36	0.37	FALSE
92	The Cancer Genome Atlas	Prostate Adenocarcinoma	SLC22A5	0.12	0.05	lasso	4	0.08	1.8e-08	-3.7	-5.1	2.8e-07	-0.44	0.96	0.00	FALSE
42	GTEx	Nerve Tibial	LYRM7	0.05	0.02	enet	11	0.04	7.0e-04	-5.3	5.1	3.1e-07	0.22	0.34	0.37	FALSE