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chr10:103,527,782-105,647,095

Best TWAS P=1.72e-14 · Best GWAS P=4.76e-13 conditioned to 0.149

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	3.98	6.4	1.7e-10	0.61	0.06	0.67	FALSE
2	GTEx	Adipose Subcutaneous	CYP17A1-AS1	0.05	0.02	enet	10	0.03	2.8e-03	4.05	6.9	5.0e-12	0.60	0.16	0.57	FALSE
3	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	-4.20	-6.1	1.4e-09	-0.27	0.59	0.15	FALSE
4	GTEx	Artery Aorta	NT5C2	0.08	0.02	lasso	7	0.01	1.2e-01	-3.75	-5.7	1.5e-08	-0.76	0.06	0.82	FALSE
5	GTEx	Artery Coronary	CYP17A1-AS1	0.20	-0.01	enet	21	0.04	2.3e-02	-0.12	5.4	5.7e-08	0.40	0.06	0.14	FALSE
6	GTEx	Artery Tibial	NT5C2	0.06	0.04	lasso	9	0.02	1.5e-02	6.93	-7.2	7.6e-13	-0.75	0.05	0.88	FALSE
7	GTEx	Artery Tibial	CYP17A1-AS1	0.08	0.08	lasso	8	0.06	2.8e-05	6.93	7.0	2.8e-12	0.70	0.08	0.91	FALSE
8	GTEx	Brain Cerebellar Hemisphere	ARL3	0.15	0.02	enet	18	0.11	1.1e-03	-5.75	5.7	1.5e-08	0.50	0.10	0.20	FALSE
9	GTEx	Brain Cerebellum	ARL3	0.20	0.09	enet	32	0.07	3.7e-03	6.39	6.6	5.3e-11	0.58	0.08	0.82	FALSE
10	GTEx	Brain Cerebellum	TRIM8	0.34	-0.01	enet	25	0.07	4.7e-03	-0.87	-5.8	5.7e-09	-0.46	0.07	0.37	TRUE
11	GTEx	Brain Cortex	CYP17A1-AS1	0.15	0.13	lasso	7	0.14	1.3e-04	6.39	7.6	3.0e-14	0.68	0.06	0.81	FALSE
12	GTEx	Brain Hypothalamus	CYP17A1-AS1	0.34	0.10	lasso	10	0.05	2.6e-02	7.00	7.5	5.7e-14	0.75	0.04	0.70	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	CYP17A1-AS1	0.39	0.22	lasso	3	0.19	8.2e-06	6.29	6.2	7.9e-10	0.59	0.18	0.29	FALSE
14	GTEx	Breast Mammary Tissue	CYP17A1-AS1	0.10	-0.01	enet	28	0.00	2.4e-01	6.99	6.7	2.9e-11	0.57	0.12	0.37	FALSE
15	GTEx	Breast Mammary Tissue (Male)	CYP17A1-AS1	0.06	0.00	lasso	3	0.01	2.1e-01	-6.10	6.7	1.5e-11	0.48	0.04	0.06	FALSE
16	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	-4.55	-5.7	1.2e-08	-0.26	0.22	0.29	FALSE
17	GTEx	Breast Mammary Tissue (Female)	CYP17A1-AS1	0.14	0.01	lasso	11	0.00	4.7e-01	4.40	6.7	2.2e-11	0.54	0.07	0.20	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	ACTR1A	0.22	0.18	lasso	3	0.19	8.0e-07	-4.67	6.2	6.4e-10	0.48	0.46	0.20	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	-6.30	6.9	6.5e-12	0.36	0.20	0.16	FALSE
20	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	-6.39	6.4	1.6e-10	0.36	0.25	0.22	FALSE
21	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	-2.38	-5.7	1.0e-08	-0.40	0.62	0.17	FALSE
22	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	-4.42	-6.8	8.4e-12	-0.56	0.24	0.59	FALSE
23	GTEx	Liver	ACTR1A	0.15	0.00	lasso	10	0.00	4.6e-01	-2.97	-6.7	1.8e-11	-0.58	0.04	0.46	FALSE
24	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	-6.29	-7.7	1.7e-14	-0.45	0.50	0.37	TRUE
25	GTEx	Lung	CYP17A1-AS1	0.06	0.08	lasso	3	0.06	1.6e-05	6.29	6.6	3.3e-11	0.63	0.25	0.69	FALSE
26	GTEx	Nerve Tibial	CYP17A1-AS1	0.14	0.08	lasso	6	0.06	7.2e-05	6.27	6.4	1.3e-10	0.61	0.41	0.36	FALSE
27	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	-4.55	-5.7	1.5e-08	-0.28	0.07	0.07	FALSE
28	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	-6.29	6.3	2.6e-10	0.35	0.81	0.17	FALSE
29	GTEx	Skin Sun Exposed Lower leg	ACTR1A	0.08	0.06	enet	10	0.07	2.7e-06	-6.40	5.1	2.7e-07	0.33	0.72	0.21	FALSE
30	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	-4.42	6.1	8.0e-10	0.39	0.99	0.01	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	CYP17A1-AS1	0.15	0.18	lasso	6	0.19	1.3e-23	6.39	6.5	1.0e-10	0.61	0.86	0.14	FALSE
32	YFS	Blood	ARL3	0.39	0.14	enet	30	0.20	7.0e-63	2.76	5.5	3.4e-08	0.44	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	AS3MT	0.06	0.09	enet	6	0.07	1.3e-06	6.35	-6.5	9.1e-11	-0.76	0.13	0.86	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C10orf32	0.06	0.06	blup	54	0.08	1.2e-07	4.19	-5.8	8.9e-09	-0.78	0.43	0.57	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	AS3MT	0.05	0.05	enet	10	0.05	4.7e-11	6.35	-5.7	1.0e-08	-0.69	0.31	0.69	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	-5.98	-5.8	5.9e-09	-0.38	0.85	0.07	FALSE
37	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	C10orf32	0.16	0.06	blup	54	0.10	1.3e-05	4.19	-5.8	8.6e-09	-0.75	0.06	0.90	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	1.70	5.2	1.8e-07	0.26	0.02	0.82	FALSE
39	The Cancer Genome Atlas	Esophageal Carcinoma	SFXN2	0.26	0.02	blup	48	0.10	4.9e-04	4.93	-5.3	1.2e-07	-0.49	0.02	0.71	FALSE
40	The Cancer Genome Atlas	Glioblastoma Multiforme	AS3MT	0.15	0.05	blup	62	0.10	5.1e-04	4.19	-5.7	1.6e-08	-0.79	0.03	0.65	FALSE
41	The Cancer Genome Atlas	Glioblastoma Multiforme	C10orf32	0.27	0.09	lasso	8	0.17	7.3e-06	4.68	-5.7	1.0e-08	-0.62	0.07	0.76	FALSE
42	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AS3MT	0.05	0.05	blup	62	0.06	1.1e-07	7.21	-5.8	8.2e-09	-0.75	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	AS3MT	0.04	0.05	enet	3	0.04	8.6e-06	6.35	-6.3	2.2e-10	-0.80	0.09	0.89	FALSE
44	The Cancer Genome Atlas	Brain Lower Grade Glioma	AS3MT	0.34	0.38	lasso	6	0.38	4.4e-46	4.19	-5.4	7.2e-08	-0.74	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Lung Adenocarcinoma	TMEM180	0.08	0.07	blup	52	0.09	1.9e-10	-6.30	5.8	6.6e-09	0.37	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TMEM180	0.05	0.02	blup	52	0.04	1.5e-05	-5.62	5.6	2.0e-08	0.38	0.02	0.94	FALSE
47	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	-6.39	-6.0	2.8e-09	-0.28	0.03	0.76	FALSE
48	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	AS3MT	0.13	0.14	blup	62	0.13	5.6e-06	6.93	-6.5	9.6e-11	-0.76	0.04	0.95	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	AS3MT	0.16	0.21	lasso	9	0.24	2.5e-24	6.33	-5.5	2.8e-08	-0.74	0.44	0.56	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	-6.25	-6.2	4.8e-10	-0.36	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Rectum Adenocarcinoma	C10orf32	0.17	0.14	blup	52	0.14	3.2e-04	6.93	-7.1	1.6e-12	-0.81	0.02	0.73	FALSE
52	The Cancer Genome Atlas	Thyroid Carcinoma	AS3MT	0.23	0.18	lasso	3	0.18	1.8e-17	6.33	-6.2	6.7e-10	-0.80	0.72	0.28	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	C10orf26	0.06	0.05	lasso	5	0.04	4.1e-05	6.65	-5.9	4.6e-09	-0.60	0.06	0.90	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	CYP17A1	0.04	0.02	lasso	1	0.02	3.9e-03	7.21	-7.2	5.8e-13	-0.74	0.01	0.90	FALSE