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chr17:60,821,100-64,251,733

Best TWAS P=2.98e-41 · Best GWAS P=2.37e-39 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	9.16	8.3	7.5e-17	-0.49	0.68	0.12	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	10.22	7.5	7.5e-14	-0.24	0.78	0.03	TRUE
3	CommonMind	Brain Pre-frontal Cortex	TCAM1P	0.05	0.03	enet	8	0.04	4.1e-06	-11.08	6.3	3.5e-10	-0.62	0.83	0.16	FALSE
4	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-12.94	13.5	3.0e-41	-0.98	0.00	1.00	TRUE
5	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	9.16	9.0	1.8e-19	-0.34	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-12.94	11.8	5.0e-32	-0.89	0.01	0.89	FALSE
7	GTEx	Adipose Visceral Omentum	MAP3K3	0.10	0.04	enet	12	0.05	9.0e-04	9.16	6.9	6.4e-12	-0.34	0.30	0.10	FALSE
8	GTEx	Artery Tibial	DDX42	0.13	0.14	lasso	5	0.15	9.1e-12	9.16	-6.4	2.0e-10	0.13	1.00	0.00	FALSE
9	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	9.95	9.9	3.7e-23	-0.39	0.83	0.02	FALSE
10	GTEx	Brain Hypothalamus	DDX42	0.15	0.18	lasso	3	0.09	4.2e-03	10.22	-7.6	2.7e-14	0.21	0.14	0.06	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	9.13	-8.1	4.6e-16	0.33	0.20	0.05	FALSE
12	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	9.16	9.1	9.0e-20	-0.36	0.95	0.00	FALSE
13	GTEx	Breast Mammary Tissue (Male)	MAP3K3	0.12	0.14	lasso	2	0.07	1.2e-02	8.60	6.6	5.2e-11	-0.13	0.15	0.06	FALSE
14	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-11.43	10.7	1.1e-26	-0.70	0.03	0.32	FALSE
15	GTEx	Breast Mammary Tissue (Female)	DCAF7	0.10	0.02	lasso	3	0.00	4.4e-01	7.76	7.8	4.9e-15	-0.29	0.07	0.06	FALSE
16	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	9.17	9.2	4.8e-20	-0.36	0.05	0.13	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	9.12	-9.1	7.5e-20	0.36	0.33	0.04	FALSE
18	GTEx	Cells Transformed fibroblasts	CD79B	0.20	0.00	lasso	4	0.00	4.3e-01	-2.58	-5.8	7.7e-09	0.32	0.11	0.08	FALSE
19	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-10.52	-9.1	8.3e-20	0.68	0.46	0.52	FALSE
20	GTEx	Colon Sigmoid	CD79B	0.17	0.00	lasso	9	0.08	9.7e-04	9.18	5.7	1.5e-08	-0.23	0.09	0.09	TRUE
21	GTEx	Esophagus Mucosa	PSMC5	0.11	0.09	lasso	4	0.14	1.1e-09	1.73	-6.2	5.9e-10	0.58	0.99	0.01	FALSE
22	GTEx	Esophagus Mucosa	DDX42	0.08	0.06	lasso	3	0.09	1.3e-06	9.20	-7.2	5.8e-13	0.19	0.96	0.00	FALSE
23	GTEx	Esophagus Mucosa	MAP3K3	0.05	0.01	enet	11	0.02	1.8e-02	5.20	6.5	5.9e-11	-0.29	0.29	0.04	FALSE
24	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-10.59	-10.5	6.0e-26	0.74	0.22	0.32	FALSE
25	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-11.18	-10.0	1.9e-23	0.74	0.45	0.16	FALSE
26	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	9.19	9.2	3.3e-20	-0.35	0.68	0.02	FALSE
27	GTEx	Esophagus Muscularis	MAP3K3	0.07	0.02	enet	8	0.02	3.0e-02	9.11	5.6	1.7e-08	-0.04	0.52	0.02	FALSE
28	GTEx	Heart Atrial Appendage	CYB561	0.19	0.01	enet	28	0.06	1.3e-03	1.15	5.4	8.1e-08	-0.28	0.06	0.26	TRUE
29	GTEx	Lung	PSMC5	0.04	0.00	enet	5	0.01	4.1e-02	1.73	-6.4	1.4e-10	0.59	0.35	0.06	TRUE
30	GTEx	Lung	TEX2	0.04	0.02	enet	13	0.01	5.0e-02	2.26	5.5	5.0e-08	-0.08	0.15	0.03	TRUE
31	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	8.60	8.6	8.3e-18	-0.36	0.94	0.01	FALSE
32	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-10.47	-8.0	1.5e-15	0.59	0.78	0.08	FALSE
33	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	9.12	9.1	7.1e-20	-0.35	0.95	0.02	FALSE
34	GTEx	Pancreas	DDX42	0.17	0.18	lasso	3	0.16	3.6e-07	9.17	-7.1	9.6e-13	0.20	0.99	0.00	FALSE
35	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	9.16	7.7	2.1e-14	-0.27	0.14	0.16	FALSE
36	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	9.17	8.2	2.1e-16	-0.28	0.13	0.05	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	9.16	9.3	1.5e-20	-0.36	1.00	0.00	FALSE
38	GTEx	Skin Sun Exposed Lower leg	PSMC5	0.07	0.02	enet	23	0.02	1.6e-02	2.65	-5.8	7.3e-09	0.54	0.23	0.06	FALSE
39	GTEx	Skin Sun Exposed Lower leg	DDX42	0.07	0.04	lasso	4	0.05	2.5e-05	9.40	-7.4	1.4e-13	0.22	0.99	0.00	FALSE
40	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	9.16	9.2	3.4e-20	-0.34	0.96	0.00	FALSE
41	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	9.13	8.9	4.1e-19	-0.34	0.46	0.05	FALSE
42	GTEx	Stomach	DCAF7	0.24	0.00	enet	33	0.08	1.2e-04	2.13	5.3	1.4e-07	-0.18	0.08	0.04	FALSE
43	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	9.40	-9.3	9.7e-21	0.37	0.89	0.05	FALSE
44	GTEx	Testis	CCDC47	0.17	0.06	enet	28	0.09	1.0e-04	-10.97	6.0	1.9e-09	-0.68	0.02	0.97	FALSE
45	GTEx	Whole Blood	CCDC47	0.05	0.00	lasso	5	0.01	9.8e-02	-0.97	-5.6	2.1e-08	0.28	0.07	0.07	FALSE
46	METSIM	Adipose	CD79B	0.04	0.01	lasso	5	0.01	4.3e-03	-3.66	6.1	8.7e-10	-0.56	0.03	0.89	FALSE
47	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	9.99	-8.2	1.9e-16	0.42	1.00	0.00	FALSE
48	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	9.99	-10.1	4.7e-24	0.39	0.99	0.00	FALSE
49	YFS	Blood	AXIN2	0.20	0.05	enet	34	0.10	5.1e-31	5.18	-6.6	4.2e-11	0.01	1.00	0.00	TRUE
50	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	7.76	-8.6	7.7e-18	0.42	1.00	0.00	FALSE
51	YFS	Blood	SMARCD2	0.03	0.04	lasso	7	0.05	7.6e-15	9.40	5.8	6.5e-09	-0.10	1.00	0.00	TRUE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-13.12	12.8	3.1e-37	-0.99	0.00	0.94	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-13.12	-10.7	1.1e-26	0.74	0.00	1.00	FALSE
54	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CSH2	0.09	0.01	blup	37	0.08	5.7e-05	1.85	6.6	4.2e-11	-0.66	0.42	0.26	FALSE
55	The Cancer Genome Atlas	Colon Adenocarcinoma	TCAM1P	0.05	0.03	blup	26	0.05	6.0e-04	2.86	6.7	2.3e-11	-0.63	0.03	0.80	FALSE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-10.52	-10.5	6.8e-26	0.75	0.00	0.90	FALSE
57	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DDX42	0.04	0.02	blup	51	0.03	3.9e-04	9.40	-5.3	1.3e-07	0.07	0.24	0.02	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SCN4A	0.05	0.01	blup	41	0.04	2.2e-05	2.48	-7.3	3.4e-13	0.66	0.02	0.93	TRUE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	2.65	8.5	2.2e-17	-0.70	0.01	0.91	FALSE
60	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	9.40	8.0	8.7e-16	-0.26	0.61	0.03	FALSE
61	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-10.52	9.8	1.9e-22	-0.73	0.00	0.79	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	TCAM1P	0.02	0.03	blup	26	0.02	9.4e-04	2.13	6.6	3.8e-11	-0.62	0.03	0.62	FALSE
63	The Cancer Genome Atlas	Lung Adenocarcinoma	SMARCD2	0.04	0.02	blup	28	0.01	1.6e-02	9.12	7.4	1.6e-13	-0.21	0.02	0.05	FALSE
64	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	FTSJ3	0.30	0.12	enet	10	0.18	6.7e-08	1.89	-5.2	2.5e-07	0.53	0.18	0.81	FALSE
65	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PSMC5	0.12	0.05	enet	19	0.07	6.2e-04	-10.97	-6.5	1.1e-10	0.53	0.01	0.84	FALSE
66	The Cancer Genome Atlas	Prostate Adenocarcinoma	DDX42	0.07	0.07	enet	11	0.07	9.2e-08	9.16	-6.4	1.7e-10	0.14	0.99	0.00	FALSE
67	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-10.97	-11.0	5.3e-28	0.76	0.01	0.96	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	8.60	8.2	2.8e-16	-0.27	0.07	0.06	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	TCAM1P	0.07	0.07	blup	26	0.08	2.8e-08	2.06	6.5	7.4e-11	-0.61	0.12	0.88	FALSE