[Hub]/) : Traits : Arm predicted mass (right) :

chr22:38,787,166-43,226,599

Best TWAS P=1.99e-10 · Best GWAS P=1.39e-15 conditioned to 5.24e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex WBP2NL 0.28 0.25 enet 16 0.35 1.3e-43 5.0 5.4 8.0e-08 -0.35 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous CYP2D6 0.26 0.10 enet 34 0.20 1.2e-16 -4.2 -6.3 2.7e-10 0.45 1.00 0.00 TRUE
3 GTEx Adrenal Gland CYP2D6 0.37 0.14 lasso 12 0.16 2.3e-06 -4.2 -5.3 1.2e-07 0.41 0.97 0.00 FALSE
4 GTEx Artery Aorta CYP2D6 0.24 0.14 lasso 5 0.24 1.6e-13 -4.3 -5.2 2.5e-07 0.40 1.00 0.00 FALSE
5 GTEx Artery Aorta APOBEC3G 0.40 0.40 lasso 3 0.39 6.3e-23 5.0 5.4 6.5e-08 0.07 0.04 0.96 FALSE
6 GTEx Artery Tibial CYP2D6 0.29 0.23 lasso 6 0.28 1.5e-22 4.5 -5.1 2.7e-07 0.37 1.00 0.00 FALSE
7 GTEx Brain Cerebellar Hemisphere CYP2D6 0.49 0.38 enet 16 0.49 1.6e-14 -4.2 -5.2 2.6e-07 0.40 1.00 0.00 FALSE
8 GTEx Brain Cortex CYP2D6 0.51 0.33 lasso 6 0.47 1.5e-14 -4.3 -5.2 2.1e-07 0.41 1.00 0.00 FALSE
9 GTEx Brain Frontal Cortex BA9 CYP2D6 0.51 0.20 lasso 5 0.34 9.0e-10 4.5 -5.3 1.1e-07 0.39 0.92 0.05 FALSE
10 GTEx Brain Frontal Cortex BA9 SLC25A17 0.11 -0.01 lasso 5 0.00 3.5e-01 -4.1 -5.4 8.4e-08 0.22 0.08 0.18 FALSE
11 GTEx Breast Mammary Tissue (Male) CYP2D6 0.34 -0.01 lasso 6 0.00 3.2e-01 4.9 -5.6 2.5e-08 0.36 0.11 0.10 FALSE
12 GTEx Breast Mammary Tissue (Female) POLR3H 0.09 -0.01 lasso 6 -0.01 6.4e-01 -5.6 5.6 1.7e-08 -0.46 0.04 0.06 FALSE
13 GTEx Breast Mammary Tissue (Female) DESI1 0.14 0.07 lasso 4 0.11 4.2e-04 -5.6 5.4 6.9e-08 -0.45 0.08 0.12 FALSE
14 GTEx Cells Transformed fibroblasts APOBEC3G 0.24 0.20 enet 11 0.24 9.4e-18 4.8 5.3 1.3e-07 0.05 0.07 0.92 FALSE
15 GTEx Colon Sigmoid DESI1 0.21 0.08 enet 6 0.11 1.2e-04 -5.6 5.4 6.4e-08 -0.47 0.40 0.05 FALSE
16 GTEx Esophagus Muscularis CYP2D6 0.33 0.18 lasso 5 0.29 5.6e-18 -3.5 -5.2 2.3e-07 0.44 1.00 0.00 FALSE
17 GTEx Lung RP5-821D11.7 0.08 0.02 enet 21 0.04 6.6e-04 3.8 6.3 3.3e-10 -0.40 0.53 0.04 FALSE
18 GTEx Nerve Tibial CYP2D6 0.32 0.21 lasso 6 0.24 2.8e-17 4.6 -5.4 5.9e-08 0.39 1.00 0.00 FALSE
19 GTEx Nerve Tibial SYNGR1 0.26 0.18 enet 27 0.21 3.6e-15 -4.4 -5.2 2.4e-07 0.05 0.18 0.81 FALSE
20 GTEx Nerve Tibial COX5BP7 0.44 0.25 enet 33 0.25 1.7e-17 3.8 -5.1 3.1e-07 0.01 0.70 0.24 FALSE
21 GTEx Pituitary OLA1P1 0.31 0.10 enet 9 0.08 5.0e-03 4.5 5.2 1.5e-07 -0.39 0.23 0.08 FALSE
22 GTEx Pituitary APOBEC3G 0.34 0.04 enet 11 0.11 1.2e-03 4.8 5.8 6.8e-09 0.03 0.02 0.83 TRUE
23 GTEx Skin Sun Exposed Lower leg APOBEC3G 0.10 0.09 lasso 3 0.06 7.5e-06 5.0 5.3 1.1e-07 0.07 0.04 0.95 FALSE
24 GTEx Spleen CCDC134 0.23 0.00 enet 14 0.09 2.7e-03 -5.6 5.8 6.7e-09 -0.40 0.07 0.07 FALSE
25 GTEx Testis SREBF2 0.25 0.03 lasso 12 0.04 4.6e-03 4.5 5.5 2.9e-08 -0.41 0.62 0.04 FALSE
26 GTEx Uterus NAGA 0.19 0.07 enet 8 0.06 2.6e-02 -4.1 5.2 1.8e-07 -0.34 0.08 0.06 FALSE
27 GTEx Vagina APOBEC3G 0.23 0.07 lasso 5 0.06 1.8e-02 4.9 5.4 6.0e-08 0.05 0.06 0.49 FALSE
28 NTR Blood SYNGR1 0.03 0.03 enet 6 0.03 1.0e-10 5.0 5.3 9.7e-08 0.08 0.04 0.96 TRUE
29 The Cancer Genome Atlas Breast Invasive Carcinoma TNRC6B 0.02 0.01 blup 92 0.01 2.7e-03 -5.0 -5.6 2.4e-08 0.12 0.02 0.78 FALSE
30 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma CYP2D6 0.14 0.09 enet 2 0.14 1.3e-07 4.5 -5.2 1.7e-07 0.38 0.00 0.91 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma CYP2D6 0.12 0.11 enet 2 0.13 7.7e-08 4.5 -5.2 1.9e-07 0.38 0.00 0.95 FALSE
32 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma WBP2NL 0.06 0.04 blup 140 0.03 9.6e-05 -5.6 6.3 3.1e-10 -0.53 0.58 0.24 FALSE
33 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ADSL 0.04 0.03 enet 6 0.03 1.6e-04 -6.5 -5.6 2.6e-08 0.02 0.00 0.94 FALSE
34 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CYP2D6 0.14 0.15 enet 2 0.17 1.4e-18 4.5 -5.1 2.8e-07 0.36 0.00 0.97 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma WBP2NL 0.10 0.04 blup 140 0.05 1.8e-06 -4.0 6.0 1.5e-09 -0.40 0.98 0.00 FALSE
36 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma CYP2D6 0.15 0.07 blup 2 0.15 4.0e-09 4.5 -5.2 1.7e-07 0.39 0.00 0.96 FALSE
37 The Cancer Genome Atlas Brain Lower Grade Glioma CYP2D6 0.19 0.17 enet 2 0.26 3.6e-29 -4.3 -5.2 1.8e-07 0.40 0.00 0.93 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma ADSL 0.03 0.00 blup 33 0.01 8.9e-03 -6.2 -5.7 1.4e-08 0.06 0.01 0.60 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma CYP2D6 0.12 0.13 enet 2 0.15 7.4e-17 4.5 -5.2 2.1e-07 0.37 0.00 0.97 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CYP2D6 0.20 0.23 enet 2 0.25 3.4e-28 4.5 -5.2 2.5e-07 0.37 0.00 0.97 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma ADSL 0.06 0.02 lasso 2 0.03 6.6e-03 -6.3 -6.3 2.7e-10 0.05 0.00 0.80 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma ADSL 0.09 0.03 lasso 3 0.01 7.7e-02 -6.5 -6.4 2.0e-10 0.11 0.00 0.76 TRUE
43 The Cancer Genome Atlas Pancreatic Adenocarcinoma CSDC2 0.25 0.01 enet 11 0.06 2.3e-03 -3.1 -5.5 3.7e-08 0.21 0.00 0.00 TRUE
44 The Cancer Genome Atlas Pancreatic Adenocarcinoma CYP2D6 0.19 0.13 enet 2 0.14 1.6e-06 4.5 -5.1 2.7e-07 0.36 0.00 0.82 FALSE
45 The Cancer Genome Atlas Prostate Adenocarcinoma WBP2NL 0.04 0.03 lasso 8 0.03 5.6e-04 5.0 5.4 6.5e-08 -0.34 0.56 0.03 FALSE
46 The Cancer Genome Atlas Soft Tissue Sarcoma CYP2D6 0.11 0.09 blup 2 0.10 1.4e-06 4.5 -5.2 2.3e-07 0.37 0.00 0.94 FALSE
47 The Cancer Genome Atlas Skin Cutaneous Melanoma CYP2D6 0.11 0.00 blup 2 0.00 2.7e-01 -4.3 -5.2 2.1e-07 0.40 0.00 0.02 FALSE
48 The Cancer Genome Atlas Stomach Adenocarcinoma CYP2D6 0.12 0.10 blup 2 0.10 6.5e-08 4.5 -5.2 2.6e-07 0.36 0.00 0.97 FALSE
49 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma CYP2D6 0.19 0.06 blup 2 0.10 9.6e-04 4.5 -5.2 1.7e-07 0.39 0.00 0.16 FALSE