Best TWAS P=2.55e-33 · Best GWAS P=1.82e-30 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | DCST2 | 0.45 | 0.10 | lasso | 6 | 0.16 | 6.6e-05 | -3.4 | 8.6 | 6.8e-18 | 0.75 | 0.01 | 0.96 | TRUE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | DCST2 | 0.28 | 0.04 | lasso | 5 | 0.13 | 2.0e-04 | 11.5 | 7.7 | 1.0e-14 | 0.69 | 0.02 | 0.90 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Female) | FAM189B | 0.05 | -0.01 | lasso | 2 | 0.00 | 4.8e-01 | -5.8 | 5.8 | 8.6e-09 | 0.09 | 0.04 | 0.06 | TRUE |
| 4 | GTEx | Esophagus Mucosa | ADAM15 | 0.11 | 0.02 | enet | 16 | 0.04 | 1.5e-03 | -5.7 | -6.2 | 5.1e-10 | -0.43 | 0.13 | 0.78 | FALSE |
| 5 | GTEx | Esophagus Mucosa | MUC1 | 0.17 | 0.20 | lasso | 4 | 0.18 | 5.6e-12 | -6.7 | -6.3 | 2.6e-10 | -0.12 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Pancreas | RP11-263K19.4 | 0.22 | 0.06 | enet | 23 | 0.05 | 3.1e-03 | 1.9 | -6.9 | 3.9e-12 | -0.43 | 0.06 | 0.49 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | GBAP1 | 0.15 | 0.06 | lasso | 4 | 0.06 | 3.6e-04 | -6.8 | 5.3 | 1.1e-07 | 0.11 | 0.54 | 0.04 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | ADAM15 | 0.14 | 0.09 | lasso | 4 | 0.08 | 6.1e-07 | 11.5 | -12.0 | 2.6e-33 | -0.96 | 0.00 | 1.00 | TRUE |
| 9 | GTEx | Testis | MUC1 | 0.20 | 0.02 | lasso | 7 | 0.07 | 7.5e-04 | -6.8 | -5.5 | 3.4e-08 | -0.11 | 0.27 | 0.05 | FALSE |
| 10 | GTEx | Thyroid | DCST2 | 0.16 | 0.12 | lasso | 2 | 0.11 | 6.4e-09 | -3.4 | 5.3 | 1.4e-07 | 0.53 | 0.39 | 0.61 | FALSE |
| 11 | METSIM | Adipose | DCST2 | 0.04 | 0.04 | enet | 12 | 0.04 | 4.3e-07 | -4.1 | 5.3 | 9.1e-08 | 0.47 | 0.85 | 0.12 | FALSE |
| 12 | NTR | Blood | ZBTB7B | 0.02 | 0.02 | lasso | 1 | 0.01 | 5.4e-05 | 6.5 | 6.5 | 6.4e-11 | 0.67 | 0.87 | 0.03 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SLC50A1 | 0.06 | 0.02 | bslmm | 331 | 0.03 | 4.3e-05 | -6.7 | -6.5 | 6.7e-11 | -0.27 | 0.64 | 0.05 | FALSE |
| 14 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | TRIM46 | 0.03 | 0.00 | blup | 33 | 0.02 | 3.6e-03 | -6.7 | -5.3 | 1.4e-07 | -0.11 | 0.02 | 0.26 | TRUE |
| 15 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADAM15 | 0.15 | 0.02 | blup | 49 | 0.08 | 1.4e-05 | 7.1 | -6.9 | 6.6e-12 | -0.34 | 0.03 | 0.04 | FALSE |
| 16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MUC1 | 0.04 | 0.01 | enet | 4 | 0.02 | 1.3e-03 | -6.7 | -5.8 | 5.4e-09 | -0.15 | 0.02 | 0.52 | TRUE |
| 17 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | RAG1AP1 | 0.07 | 0.00 | blup | 76 | 0.00 | 2.9e-01 | -2.4 | -5.2 | 1.7e-07 | -0.17 | 0.02 | 0.11 | TRUE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAM15 | 0.09 | 0.00 | blup | 49 | 0.02 | 3.6e-02 | -1.1 | -6.5 | 8.6e-11 | -0.43 | 0.01 | 0.09 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB7B | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.8e-06 | 11.5 | -11.5 | 1.6e-30 | -1.00 | 0.00 | 1.00 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBA | 0.05 | 0.01 | lasso | 2 | 0.01 | 2.3e-02 | 7.1 | -6.2 | 4.5e-10 | -0.07 | 0.00 | 0.78 | TRUE |