[Hub]/) : Traits : Trunk fat-free mass :

chr2:217,456,567-220,374,137

Best TWAS P=1.44e-18 · Best GWAS P=7.5e-33 conditioned to 9.24e-14

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous BCS1L 0.06 0.01 enet 9 0.04 2.3e-04 -4.0 7.6 2.8e-14 -0.04 0.07 0.23 FALSE
2 GTEx Adipose Subcutaneous PNKD 0.12 0.08 lasso 3 0.07 4.2e-06 -5.1 5.7 9.7e-09 0.09 0.11 0.88 FALSE
3 GTEx Adipose Subcutaneous TMBIM1 0.12 0.08 lasso 5 0.10 2.9e-08 -5.2 5.3 9.0e-08 0.08 0.76 0.24 FALSE
4 GTEx Adipose Subcutaneous ARPC2 0.16 0.16 enet 12 0.17 4.4e-14 -5.5 6.2 7.3e-10 0.06 0.94 0.06 FALSE
5 GTEx Adipose Subcutaneous RP11-378A13.1 0.25 0.34 lasso 9 0.37 2.4e-31 -5.4 6.0 2.1e-09 0.10 0.94 0.06 FALSE
6 GTEx Adipose Visceral Omentum PNKD 0.11 0.00 enet 31 0.00 2.3e-01 -7.3 8.1 5.3e-16 0.06 0.01 0.93 TRUE
7 GTEx Adipose Visceral Omentum TMBIM1 0.17 0.03 enet 31 0.03 1.1e-02 -6.1 6.9 3.9e-12 0.09 0.02 0.96 FALSE
8 GTEx Adipose Visceral Omentum RP11-378A13.1 0.30 0.28 enet 30 0.32 2.9e-17 -6.2 5.9 4.4e-09 0.12 0.36 0.64 FALSE
9 GTEx Adrenal Gland PNKD 0.20 0.16 lasso 5 0.19 1.6e-07 -6.3 6.7 2.1e-11 0.07 0.04 0.96 FALSE
10 GTEx Adrenal Gland RP11-378A13.1 0.25 0.22 enet 17 0.30 3.2e-11 -5.4 6.1 1.3e-09 0.09 0.03 0.97 FALSE
11 GTEx Artery Aorta TMBIM1 0.17 0.20 enet 29 0.19 1.2e-10 -5.4 6.1 1.1e-09 0.11 0.34 0.66 FALSE
12 GTEx Artery Aorta RP11-378A13.1 0.28 0.28 enet 20 0.31 2.2e-17 -6.2 6.0 2.2e-09 0.10 0.58 0.42 FALSE
13 GTEx Artery Coronary TMBIM1 0.22 0.08 lasso 1 0.03 3.6e-02 -5.5 5.5 3.9e-08 0.09 0.09 0.44 FALSE
14 GTEx Artery Coronary RP11-378A13.1 0.34 0.36 lasso 8 0.38 1.2e-13 -5.4 6.1 1.2e-09 0.09 0.02 0.98 FALSE
15 GTEx Artery Tibial TMBIM1 0.18 0.14 enet 30 0.13 3.2e-10 -5.2 6.3 3.2e-10 0.06 0.99 0.01 FALSE
16 GTEx Artery Tibial RP11-378A13.1 0.20 0.17 enet 13 0.24 7.6e-19 -7.3 6.4 1.6e-10 0.07 0.01 0.99 FALSE
17 GTEx Brain Caudate basal ganglia RP11-378A13.1 0.55 0.38 enet 17 0.52 4.0e-17 -6.2 6.3 2.7e-10 0.09 0.02 0.98 FALSE
18 GTEx Brain Cerebellar Hemisphere RP11-378A13.1 0.53 0.57 enet 24 0.60 3.3e-19 -6.2 6.4 2.0e-10 0.07 0.05 0.95 FALSE
19 GTEx Brain Cerebellum RP11-378A13.1 0.46 0.52 enet 15 0.46 2.5e-15 -6.2 6.1 8.8e-10 0.10 0.11 0.89 FALSE
20 GTEx Brain Cortex PNKD 0.18 0.12 enet 7 0.11 6.8e-04 -4.6 -5.5 3.6e-08 -0.10 0.06 0.83 FALSE
21 GTEx Brain Cortex RP11-378A13.1 0.61 0.56 enet 23 0.61 6.7e-21 -6.1 6.3 2.3e-10 0.10 0.10 0.90 FALSE
22 GTEx Brain Frontal Cortex BA9 RP11-378A13.1 0.38 0.54 enet 24 0.49 7.2e-15 -6.1 6.3 3.6e-10 0.10 0.16 0.84 FALSE
23 GTEx Brain Hypothalamus RP11-378A13.1 0.37 0.44 enet 17 0.45 5.6e-12 -6.2 6.9 6.6e-12 0.10 0.01 0.99 FALSE
24 GTEx Brain Nucleus accumbens basal ganglia RP11-378A13.1 0.47 0.51 lasso 5 0.48 1.5e-14 -6.1 -6.1 8.5e-10 -0.10 0.36 0.64 FALSE
25 GTEx Brain Putamen basal ganglia RP11-378A13.1 0.35 0.28 enet 18 0.29 1.2e-07 -6.1 6.1 1.0e-09 0.09 0.04 0.95 FALSE
26 GTEx Breast Mammary Tissue RP11-378A13.1 0.27 0.26 enet 20 0.30 1.3e-15 -5.1 5.9 3.7e-09 0.09 0.59 0.41 FALSE
27 GTEx Breast Mammary Tissue (Female) USP37 0.16 0.00 enet 10 0.00 3.7e-01 -5.8 5.8 7.5e-09 -0.08 0.06 0.06 FALSE
28 GTEx Breast Mammary Tissue (Female) ARPC2 0.12 -0.01 lasso 5 -0.01 7.1e-01 -5.0 6.1 1.3e-09 0.08 0.05 0.46 FALSE
29 GTEx Breast Mammary Tissue (Female) RP11-378A13.1 0.30 0.11 lasso 10 0.22 3.0e-07 -5.2 5.9 3.6e-09 0.10 0.06 0.94 FALSE
30 GTEx Cells EBV-transformed lymphocytes TMBIM1 0.35 0.24 lasso 10 0.24 2.3e-08 -5.2 5.6 1.7e-08 0.10 0.90 0.10 FALSE
31 GTEx Cells EBV-transformed lymphocytes RP11-378A13.1 0.18 0.14 lasso 6 0.13 4.6e-05 -5.4 5.6 1.9e-08 0.08 0.14 0.64 FALSE
32 GTEx Cells Transformed fibroblasts TMBIM1 0.15 0.25 lasso 3 0.27 2.2e-20 -5.4 5.5 4.7e-08 0.08 0.99 0.01 FALSE
33 GTEx Cells Transformed fibroblasts RP11-378A13.1 0.29 0.26 enet 24 0.31 2.0e-23 -5.2 5.8 4.8e-09 0.12 0.95 0.05 FALSE
34 GTEx Colon Sigmoid RP11-378A13.1 0.31 0.33 enet 23 0.34 6.0e-13 -6.1 6.2 4.2e-10 0.09 0.10 0.90 FALSE
35 GTEx Colon Transverse TMBIM1 0.10 0.00 lasso 6 -0.01 6.8e-01 -5.4 5.5 3.1e-08 0.10 0.06 0.48 FALSE
36 GTEx Colon Transverse RP11-378A13.1 0.35 0.31 lasso 6 0.43 4.6e-22 -5.4 6.1 1.3e-09 0.09 0.04 0.96 FALSE
37 GTEx Esophagus Gastroesophageal Junction RP11-378A13.1 0.37 0.37 enet 26 0.33 1.1e-12 -6.1 6.0 2.6e-09 0.12 0.05 0.95 FALSE
38 GTEx Esophagus Mucosa RP11-378A13.1 0.28 0.32 enet 27 0.39 1.3e-27 -6.1 6.3 3.0e-10 0.10 0.59 0.41 FALSE
39 GTEx Esophagus Muscularis RP11-378A13.1 0.37 0.42 enet 21 0.41 6.9e-27 -6.1 6.3 3.9e-10 0.10 0.44 0.56 FALSE
40 GTEx Heart Atrial Appendage TMBIM1 0.11 0.09 lasso 2 0.08 1.8e-04 -5.5 6.0 2.4e-09 0.07 0.05 0.94 FALSE
41 GTEx Heart Atrial Appendage RP11-378A13.1 0.26 0.17 enet 13 0.22 2.0e-10 -6.2 6.0 1.8e-09 0.10 0.40 0.60 FALSE
42 GTEx Heart Left Ventricle TMBIM1 0.12 0.08 enet 11 0.07 1.4e-04 -5.6 6.1 1.1e-09 0.09 0.21 0.77 FALSE
43 GTEx Heart Left Ventricle RP11-378A13.1 0.21 0.16 enet 27 0.19 1.3e-10 -5.4 5.6 2.6e-08 0.08 0.22 0.78 FALSE
44 GTEx Lung BCS1L 0.06 0.00 enet 58 0.00 4.8e-01 -3.8 6.0 2.2e-09 -0.01 0.06 0.10 TRUE
45 GTEx Lung PNKD 0.13 0.04 enet 10 0.03 3.7e-03 -6.9 6.6 4.6e-11 0.08 0.02 0.98 FALSE
46 GTEx Lung ARPC2 0.19 0.10 lasso 7 0.09 1.6e-07 -5.8 5.9 3.2e-09 0.08 0.80 0.20 FALSE
47 GTEx Lung RP11-378A13.1 0.27 0.30 enet 19 0.37 2.3e-29 -5.4 6.1 9.3e-10 0.10 0.64 0.36 FALSE
48 GTEx Muscle Skeletal ARPC2 0.23 0.17 enet 18 0.20 1.9e-19 -5.0 5.6 2.5e-08 0.08 1.00 0.00 FALSE
49 GTEx Muscle Skeletal RP11-378A13.1 0.19 0.27 enet 23 0.31 1.7e-30 -6.1 6.2 4.7e-10 0.09 0.47 0.53 FALSE
50 GTEx Nerve Tibial ARPC2 0.29 0.30 enet 27 0.26 1.1e-18 -5.5 5.7 1.4e-08 0.08 0.99 0.01 FALSE
51 GTEx Nerve Tibial RP11-378A13.1 0.33 0.31 enet 35 0.36 1.0e-26 -6.0 5.4 5.6e-08 0.10 0.70 0.30 FALSE
52 GTEx Ovary RP11-378A13.1 0.35 0.15 enet 38 0.14 2.1e-04 -4.8 5.3 9.9e-08 0.08 0.09 0.81 FALSE
53 GTEx Pancreas PNKD 0.12 0.10 lasso 3 0.08 3.6e-04 -7.3 7.0 2.6e-12 0.05 0.00 0.98 FALSE
54 GTEx Pancreas RP11-378A13.1 0.29 0.14 enet 24 0.16 4.4e-07 -6.2 6.3 2.4e-10 0.08 0.03 0.97 FALSE
55 GTEx Pituitary PNKD 0.29 0.23 enet 21 0.24 8.9e-07 -7.3 6.8 1.5e-11 0.09 0.01 0.99 FALSE
56 GTEx Pituitary TMBIM1 0.20 0.16 enet 13 0.02 8.4e-02 -6.1 6.0 1.9e-09 0.10 0.10 0.75 FALSE
57 GTEx Pituitary RP11-378A13.1 0.64 0.52 enet 19 0.52 2.7e-15 -6.2 6.0 1.6e-09 0.08 0.32 0.68 FALSE
58 GTEx Prostate RP11-378A13.1 0.29 0.12 enet 14 0.10 2.1e-03 -5.4 5.7 1.2e-08 0.11 0.02 0.93 FALSE
59 GTEx Skin Not Sun Exposed Suprapubic PNKD 0.28 0.28 enet 9 0.26 9.7e-15 -6.2 6.5 6.1e-11 0.08 0.36 0.64 FALSE
60 GTEx Skin Not Sun Exposed Suprapubic RP11-378A13.1 0.26 0.25 lasso 8 0.28 5.6e-16 -6.3 6.4 1.3e-10 0.09 0.38 0.62 FALSE
61 GTEx Skin Sun Exposed Lower leg PNKD 0.27 0.29 lasso 8 0.34 3.9e-29 -6.3 6.5 8.5e-11 0.08 0.40 0.60 FALSE
62 GTEx Skin Sun Exposed Lower leg RP11-378A13.1 0.29 0.36 enet 28 0.40 9.8e-35 -5.4 5.8 4.9e-09 0.10 0.97 0.03 FALSE
63 GTEx Small Intestine Terminal Ileum RP11-378A13.1 0.39 0.17 enet 15 0.14 4.5e-04 -6.2 6.8 1.1e-11 0.06 0.03 0.93 FALSE
64 GTEx Spleen RP11-378A13.1 0.37 0.41 enet 27 0.41 1.2e-11 -5.4 6.5 6.4e-11 0.07 0.02 0.98 FALSE
65 GTEx Stomach RP11-378A13.1 0.32 0.32 enet 20 0.34 3.4e-17 -5.2 5.7 1.0e-08 0.09 0.89 0.11 FALSE
66 GTEx Testis PNKD 0.20 0.19 lasso 3 0.19 1.2e-08 -5.4 5.5 3.5e-08 0.09 0.84 0.16 FALSE
67 GTEx Testis TMBIM1 0.27 0.13 enet 20 0.15 2.7e-07 -6.2 6.1 9.6e-10 0.06 0.73 0.25 FALSE
68 GTEx Testis RP11-378A13.1 0.37 0.18 enet 22 0.22 2.7e-10 -5.2 6.6 3.8e-11 0.09 0.49 0.51 FALSE
69 GTEx Thyroid PNKD 0.13 0.12 enet 13 0.14 6.3e-11 -7.3 6.6 3.5e-11 0.07 0.00 1.00 FALSE
70 GTEx Thyroid CYP27A1 0.07 0.05 enet 23 0.04 4.8e-04 -3.1 -5.3 1.4e-07 0.06 0.88 0.00 FALSE
71 GTEx Thyroid ARPC2 0.10 0.03 enet 8 0.04 3.0e-04 -5.0 5.4 8.0e-08 0.08 0.53 0.25 FALSE
72 GTEx Thyroid RP11-378A13.1 0.31 0.34 enet 34 0.38 3.7e-30 -6.1 6.5 7.7e-11 0.10 0.11 0.89 FALSE
73 GTEx Vagina RP11-378A13.1 0.22 0.07 enet 11 0.03 7.1e-02 -6.1 6.4 2.0e-10 0.10 0.11 0.36 FALSE
74 GTEx Whole Blood PNKD 0.05 0.04 lasso 3 0.03 4.4e-04 -6.1 6.5 8.8e-11 0.10 0.05 0.93 FALSE
75 GTEx Whole Blood RP11-378A13.1 0.11 0.13 enet 18 0.15 1.6e-13 -5.4 6.1 8.2e-10 0.09 0.36 0.64 FALSE
76 METSIM Adipose AAMP 0.03 0.00 bslmm 433 0.01 7.1e-03 -5.0 6.5 5.8e-11 0.08 0.06 0.83 FALSE
77 METSIM Adipose CXCR2 0.04 0.00 blup 436 0.02 1.1e-03 -5.3 6.6 3.6e-11 0.13 0.11 0.61 FALSE
78 METSIM Adipose PNKD 0.07 0.08 lasso 7 0.08 4.8e-12 -7.3 7.2 4.7e-13 0.07 0.00 1.00 FALSE
79 METSIM Adipose TMBIM1 0.14 0.15 lasso 11 0.14 1.3e-20 -5.2 5.7 1.1e-08 0.09 0.92 0.08 FALSE
80 NTR Blood ARPC2 0.02 0.01 blup 462 0.01 4.8e-05 -4.0 6.4 1.3e-10 0.08 0.45 0.51 FALSE
81 NTR Blood CXCR1 0.03 0.03 lasso 8 0.03 1.1e-08 5.3 5.4 7.1e-08 0.09 0.98 0.02 FALSE
82 NTR Blood CXCR2 0.03 0.02 lasso 2 0.02 2.9e-06 -5.7 5.6 2.4e-08 0.10 0.72 0.27 FALSE
83 ROSMAP Brain Pre-frontal Cortex ZNF142 0.03 0.01 enet 8 0.01 7.3e-03 -4.1 -6.1 9.3e-10 0.07 0.49 0.02 FALSE
84 ROSMAP Brain Pre-frontal Cortex GPBAR1 0.06 0.05 blup 430 0.05 3.2e-07 -5.7 -5.5 4.9e-08 -0.10 0.93 0.07 FALSE
85 ROSMAP Brain Pre-frontal Cortex DIRC3 0.12 0.07 bslmm 697 0.08 2.7e-10 -7.6 8.0 1.9e-15 0.00 1.00 0.00 TRUE
86 ROSMAP Brain Pre-frontal Cortex RP11-378A13.1 0.44 0.64 bslmm 431 0.64 1.1e-107 -6.1 6.4 1.5e-10 0.11 0.71 0.29 FALSE
87 YFS Blood AAMP 0.02 0.02 lasso 3 0.01 4.1e-05 -5.9 5.9 3.8e-09 0.07 0.80 0.13 FALSE
88 YFS Blood GPBAR1 0.04 0.06 lasso 10 0.06 2.3e-18 -6.1 -6.3 2.1e-10 -0.10 0.47 0.53 FALSE
89 YFS Blood PNKD 0.08 0.07 lasso 6 0.09 2.9e-27 -5.6 6.9 3.8e-12 0.05 0.04 0.96 FALSE
90 YFS Blood TNS1 0.15 0.11 bslmm 547 0.12 8.3e-38 -3.7 -5.1 2.8e-07 0.11 1.00 0.00 TRUE
91 YFS Blood ZNF142 0.10 0.12 lasso 8 0.16 1.1e-51 -4.1 -6.0 2.3e-09 0.07 1.00 0.00 FALSE
92 The Cancer Genome Atlas Breast Invasive Carcinoma TMBIM1 0.04 0.01 blup 49 0.02 4.8e-05 -6.2 6.6 3.3e-11 0.09 0.10 0.85 FALSE
93 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMBIM1 0.02 0.01 blup 49 0.02 2.6e-03 -5.3 5.9 3.5e-09 0.10 0.03 0.90 FALSE
94 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DIRC3 0.12 0.01 blup 275 0.02 3.3e-03 -1.2 7.1 9.6e-13 -0.51 0.05 0.51 TRUE
95 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PLCD4 0.10 0.09 blup 61 0.09 1.6e-10 -5.6 -5.7 1.1e-08 0.08 0.02 0.98 FALSE
96 The Cancer Genome Atlas Brain Lower Grade Glioma ZNF142 0.06 0.05 enet 11 0.05 3.1e-06 -5.7 -6.2 4.0e-10 0.09 0.01 0.98 FALSE
97 The Cancer Genome Atlas Soft Tissue Sarcoma TMBIM1 0.07 0.04 blup 49 0.03 4.8e-03 -6.2 5.3 1.4e-07 0.08 0.04 0.59 FALSE
98 The Cancer Genome Atlas Thyroid Carcinoma DIRC3 0.08 0.06 lasso 5 0.07 2.7e-07 -9.4 8.8 1.4e-18 -0.56 0.98 0.01 TRUE
99 The Cancer Genome Atlas Thyroid Carcinoma TMBIM1 0.02 0.02 blup 49 0.02 9.3e-03 -5.1 5.1 2.9e-07 0.08 0.05 0.18 FALSE
100 The Cancer Genome Atlas Thyroid Carcinoma ZNF142 0.09 0.03 blup 46 0.03 7.6e-04 -4.0 -5.6 1.7e-08 0.06 0.22 0.10 FALSE