[Hub]/) : Traits : Wheeze or whistling in the chest in last year : ← →

chr17:36,710,513-39,048,774

Best TWAS P=1.92e-14 · Best GWAS P=2.57e-13 conditioned to 0.0568

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ORMDL3	0.09	0.08	enet	10	0.06	4.2e-08	7.1	6.8	1.1e-11	0.84	0.02	0.98	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PNMT	0.05	0.00	bslmm	327	0.00	8.2e-02	5.3	-5.7	1.0e-08	-0.50	0.06	0.06	FALSE
3	GTEx	Brain Nucleus accumbens basal ganglia	RAPGEFL1	0.16	0.06	lasso	4	0.07	7.7e-03	-6.4	-7.7	1.9e-14	-0.81	0.04	0.75	TRUE
4	GTEx	Breast Mammary Tissue	PGAP3	0.10	0.07	lasso	4	0.07	1.5e-04	5.1	5.5	4.6e-08	0.58	0.20	0.34	FALSE
5	GTEx	Breast Mammary Tissue	ORMDL3	0.17	0.04	enet	27	0.06	7.2e-04	-5.6	-5.5	4.4e-08	-0.72	0.06	0.88	FALSE
6	GTEx	Breast Mammary Tissue (Female)	PGAP3	0.10	-0.01	enet	18	0.01	2.0e-01	4.9	5.4	6.2e-08	0.52	0.06	0.23	FALSE
7	GTEx	Cells Transformed fibroblasts	GSDMB	0.11	0.02	enet	18	0.06	4.9e-05	7.1	7.2	4.0e-13	0.75	0.01	0.98	FALSE
8	GTEx	Cells Transformed fibroblasts	ORMDL3	0.24	0.09	enet	21	0.07	7.8e-06	7.1	7.3	3.1e-13	0.81	0.01	0.99	FALSE
9	GTEx	Colon Transverse	GSDMB	0.14	0.11	enet	18	0.12	2.0e-06	-6.2	6.9	4.2e-12	0.88	0.02	0.98	FALSE
10	GTEx	Colon Transverse	PGAP3	0.24	0.20	enet	19	0.20	8.3e-10	4.9	5.5	2.9e-08	0.60	0.99	0.01	FALSE
11	GTEx	Esophagus Mucosa	GSDMB	0.06	0.04	lasso	3	0.03	4.7e-03	5.5	6.2	5.9e-10	0.73	0.03	0.89	FALSE
12	GTEx	Esophagus Mucosa	ORMDL3	0.09	0.01	enet	20	0.00	1.8e-01	5.3	6.2	4.5e-10	0.64	0.02	0.79	FALSE
13	GTEx	Esophagus Muscularis	PGAP3	0.11	0.08	enet	10	0.10	1.1e-06	4.9	5.3	8.6e-08	0.68	0.63	0.35	FALSE
14	GTEx	Heart Atrial Appendage	PPP1R1B	0.09	0.04	enet	10	0.08	2.2e-04	5.7	6.6	4.9e-11	0.82	0.05	0.91	FALSE
15	GTEx	Heart Atrial Appendage	PNMT	0.14	-0.01	lasso	8	0.00	5.3e-01	-6.4	5.6	2.2e-08	0.85	0.12	0.41	FALSE
16	GTEx	Liver	PGAP3	0.27	0.17	lasso	4	0.13	1.7e-04	4.9	5.7	1.0e-08	0.67	0.46	0.37	FALSE
17	GTEx	Lung	GSDMB	0.07	0.07	lasso	4	0.05	1.5e-04	7.1	7.6	3.2e-14	0.91	0.02	0.97	FALSE
18	GTEx	Lung	ORMDL3	0.16	0.13	enet	15	0.14	1.6e-10	7.1	7.2	6.6e-13	0.91	0.02	0.98	FALSE
19	GTEx	Muscle Skeletal	PGAP3	0.04	0.03	lasso	5	0.04	1.3e-04	4.9	6.3	3.8e-10	0.57	0.65	0.05	FALSE
20	GTEx	Nerve Tibial	PGAP3	0.19	0.11	lasso	5	0.12	1.1e-08	4.9	5.5	4.1e-08	0.56	0.98	0.02	FALSE
21	GTEx	Pancreas	PGAP3	0.37	0.25	lasso	6	0.21	1.9e-09	4.9	5.7	1.1e-08	0.72	0.77	0.23	FALSE
22	GTEx	Pituitary	MED24	0.37	0.28	lasso	3	0.21	6.1e-06	6.1	-6.1	1.2e-09	-0.27	0.47	0.04	FALSE
23	GTEx	Pituitary	MSL1	0.40	0.27	lasso	7	0.24	1.3e-06	4.3	-5.3	9.9e-08	-0.24	0.22	0.15	FALSE
24	GTEx	Prostate	PGAP3	0.23	0.03	enet	26	0.06	1.6e-02	4.9	5.9	3.7e-09	0.58	0.20	0.18	FALSE
25	GTEx	Skin Sun Exposed Lower leg	ERBB2	0.10	0.01	enet	8	0.01	3.5e-02	4.3	5.7	1.0e-08	0.81	0.17	0.57	FALSE
26	GTEx	Spleen	MED24	0.35	0.21	lasso	6	0.24	6.5e-07	4.8	-5.3	1.1e-07	-0.24	0.68	0.03	FALSE
27	GTEx	Spleen	GSDMB	0.50	0.45	enet	14	0.43	1.9e-12	7.1	6.8	7.8e-12	0.90	0.02	0.98	FALSE
28	GTEx	Spleen	ORMDL3	0.40	0.44	enet	11	0.39	5.7e-11	7.1	7.4	1.8e-13	0.92	0.02	0.98	FALSE
29	GTEx	Testis	MSL1	0.23	0.05	enet	9	0.15	2.9e-07	4.2	-5.2	1.6e-07	-0.39	0.29	0.20	FALSE
30	GTEx	Thyroid	THRA	0.06	0.01	lasso	4	0.00	3.5e-01	-4.3	5.2	1.8e-07	0.25	0.05	0.48	FALSE
31	GTEx	Thyroid	PGAP3	0.19	0.21	lasso	10	0.24	3.5e-18	4.6	5.5	4.5e-08	0.72	1.00	0.00	FALSE
32	GTEx	Thyroid	RP11-690G19.3	0.04	0.03	enet	6	0.02	1.5e-02	5.6	-5.3	1.0e-07	-0.61	0.01	0.96	FALSE
33	GTEx	Whole Blood	GSDMB	0.15	0.10	lasso	4	0.10	4.5e-09	7.1	6.8	7.7e-12	0.96	0.02	0.98	FALSE
34	GTEx	Whole Blood	ORMDL3	0.18	0.12	lasso	5	0.14	1.8e-12	7.1	6.9	4.5e-12	0.89	0.04	0.96	FALSE
35	METSIM	Adipose	GSDMA	0.14	0.16	lasso	7	0.17	2.6e-24	5.5	-5.8	7.3e-09	-0.58	1.00	0.00	FALSE
36	METSIM	Adipose	RP11-387H17.4	0.04	0.00	bslmm	286	0.01	8.4e-03	1.3	-5.2	1.9e-07	-0.69	0.03	0.68	FALSE
37	NTR	Blood	GSDMB	0.09	0.10	enet	16	0.12	3.8e-36	7.2	6.7	2.2e-11	0.92	0.01	0.99	FALSE
38	NTR	Blood	IKZF3	0.04	0.03	blup	319	0.02	1.5e-08	-6.5	-7.6	4.0e-14	-0.85	0.05	0.95	FALSE
39	NTR	Blood	ORMDL3	0.10	0.10	enet	24	0.12	4.4e-36	-6.3	5.7	1.2e-08	0.88	0.03	0.97	FALSE
40	YFS	Blood	GSDMB	0.36	0.41	lasso	12	0.49	4.0e-186	7.1	6.4	1.7e-10	0.89	0.02	0.98	FALSE
41	YFS	Blood	ORMDL3	0.31	0.36	lasso	9	0.45	2.2e-165	7.1	6.1	1.2e-09	0.86	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PGAP3	0.07	0.12	blup	37	0.11	1.2e-09	4.9	5.3	1.2e-07	0.64	0.07	0.92	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	PGAP3	0.08	0.07	blup	41	0.08	2.7e-16	4.9	5.9	3.5e-09	0.62	0.06	0.93	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	STARD3	0.04	0.01	blup	50	0.03	4.2e-06	2.7	5.8	7.4e-09	0.44	0.08	0.77	FALSE
45	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PGAP3	0.04	0.01	blup	41	0.01	1.2e-01	4.9	5.2	2.1e-07	0.62	0.02	0.70	FALSE
46	The Cancer Genome Atlas	Colon Adenocarcinoma	GSDMB	0.10	0.15	blup	40	0.14	1.2e-08	-6.3	6.6	5.4e-11	0.89	0.03	0.97	FALSE
47	The Cancer Genome Atlas	Colon Adenocarcinoma	PGAP3	0.10	0.17	blup	37	0.17	6.4e-10	4.9	5.7	1.4e-08	0.65	0.06	0.93	FALSE
48	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ORMDL3	0.01	0.01	blup	36	0.00	8.5e-02	-6.3	6.7	1.6e-11	0.88	0.02	0.62	FALSE
49	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PGAP3	0.12	0.12	lasso	4	0.13	5.3e-14	4.9	5.4	5.6e-08	0.57	0.06	0.94	FALSE
50	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSDMB	0.06	0.05	enet	7	0.05	2.2e-06	7.1	7.2	6.6e-13	0.95	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Lung Adenocarcinoma	GSDMB	0.05	0.07	blup	39	0.05	1.4e-06	7.1	7.4	1.8e-13	0.92	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GSDMB	0.02	0.01	blup	39	0.01	1.5e-02	7.1	6.8	1.2e-11	0.91	0.02	0.82	FALSE
53	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ORMDL3	0.03	0.04	lasso	2	0.04	2.9e-05	-6.2	6.8	1.0e-11	0.92	0.03	0.97	FALSE
54	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	GSDMB	0.14	0.16	lasso	4	0.14	2.4e-06	-6.3	6.2	4.8e-10	0.86	0.14	0.84	FALSE
55	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PGAP3	0.07	0.10	lasso	2	0.08	3.7e-04	5.6	5.7	1.6e-08	0.57	0.00	0.94	FALSE
56	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PGAP3	0.17	0.13	blup	41	0.10	6.8e-05	4.6	5.2	2.5e-07	0.66	0.08	0.82	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	STARD3	0.05	0.04	blup	50	0.05	9.8e-06	4.9	5.2	2.5e-07	0.53	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Rectum Adenocarcinoma	GSDMB	0.14	0.09	blup	39	0.17	7.0e-05	-6.1	7.0	1.8e-12	0.89	0.02	0.89	FALSE
59	The Cancer Genome Atlas	Rectum Adenocarcinoma	PGAP3	0.20	0.14	blup	38	0.16	1.4e-04	5.1	5.5	4.6e-08	0.67	0.02	0.69	FALSE
60	The Cancer Genome Atlas	Skin Cutaneous Melanoma	GSDMA	0.23	0.16	blup	47	0.18	1.3e-05	4.4	-6.0	2.4e-09	-0.51	0.14	0.42	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSDMB	0.06	0.08	enet	7	0.08	1.1e-06	7.2	7.0	3.4e-12	0.90	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Stomach Adenocarcinoma	IKZF3	0.03	0.01	blup	43	0.02	1.3e-02	7.1	-6.8	8.9e-12	-0.83	0.01	0.71	FALSE
63	The Cancer Genome Atlas	Stomach Adenocarcinoma	PGAP3	0.05	0.05	lasso	4	0.05	1.0e-04	4.5	5.6	1.7e-08	0.62	0.01	0.97	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	ZPBP2	0.08	0.09	enet	5	0.10	6.1e-08	7.0	-7.2	5.7e-13	-0.93	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PNMT	0.07	0.14	lasso	1	0.10	1.5e-04	5.6	5.6	1.6e-08	0.57	0.00	0.99	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	GSDMB	0.08	0.08	blup	40	0.09	6.6e-09	7.1	7.4	9.9e-14	0.88	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	ORMDL3	0.08	0.13	blup	37	0.15	3.8e-14	7.1	7.4	1.3e-13	0.91	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	PNMT	0.03	0.05	lasso	4	0.04	6.2e-05	5.6	5.7	1.4e-08	0.60	0.00	0.99	FALSE