TWAS hub - NDST2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0958	0.0286	0.00000	0.094	0.086	0.095	0.09	0.097	5.6e-29	9.1e-27	2.7e-29	4.8e-28	5.0e-30
2	TCGA	Prostate Adenocarcinoma	0.0315	0.0234	0.00094	0.023	0.020	0.018	NA	0.019	1.5e-03	3.3e-03	5.0e-03	NA	3.5e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Forced expiratory volume in 1-second (FEV1)	11.7	39.6	46.9	-6.8	-5.7
Shortness of breath walking on level ground	10.3	12.2	13.3	3.6	3.3
Forced expiratory volume in 1-second (FEV1), Best measure	9.5	30.4	37.0	-6.1	-4.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	8.6	18.2	28.2	-5.3	-2.9
Lung FVC	8.4	42.9	71.2	-8.4	-3.8
Lung FEV1/FVC ratio	7.6	38.3	43.4	-5.8	-6.6
Smoking status: Current	7.6	12.1	14.7	3.8	3.1
Crohns Disease (2017)	7.0	15.4	30.3	5.5	-0.6
Leg pain on walking	7.0	8.8	15.4	3.9	1.5
Respiratory disease	6.9	15.4	16.2	3.8	4.0
Wheeze or whistling in the chest in last year	6.5	11.6	18.8	4.3	2.1
Coronary Artery Disease (CAD)	6.3	7.5	11.9	3.4	1.8
Peak expiratory flow (PEF)	6.2	14.4	14.7	-3.7	-3.8
Systolic blood pressure, automated reading	6.1	17.7	33.9	1.2	5.8
Asthma	6.1	12.1	17.0	4.1	2.7
Current tobacco smoking	5.9	9.7	12.2	3.5	2.7
Maternal smoking around birth	5.9	8.6	10.4	3.2	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.8	6.8	9.4	-2.0	-3.1
Allergy	5.7	13.1	14.3	-3.8	-3.4
Asthma (self-reported)	5.7	11.4	15.8	4.0	2.6
Systolic Blood Pressure	5.3	26.6	52.3	-1.0	7.2
Forced vital capacity (FVC)	5.3	20.4	28.4	-5.3	-3.5
Average weekly beer plus cider intake	4.9	7.1	13.6	3.7	0.8
Allergy or Eczema	4.8	12.7	15.0	3.2	3.9
Pack years of smoking	4.8	7.1	12.9	3.6	1.1
Pack years adult smoking proportion	4.7	7.2	13.0	3.6	1.2
Hair/balding pattern: Pattern 2	4.7	5.9	11.0	0.9	3.3
Frequency of tiredness / lethargy in last 2 weeks	4.7	7.6	14.5	3.8	0.9
Exposure to tobacco smoke at home	4.5	5.0	9.8	3.1	0.5
Exposure to tobacco smoke outside home	4.5	6.0	11.9	3.4	-0.3
Townsend deprivation index at recruitment	4.4	6.2	6.9	2.4	2.6
Ever had bowel cancer screening	4.4	5.1	7.6	-2.8	-1.6
Diverticular disease/diverticulitis (self-reported)	4.3	5.2	6.8	-1.9	-2.6
Forced vital capacity (FVC), Best measure	4.3	15.8	22.6	-4.8	-3.0
Pulse rate, automated reading	4.3	14.0	16.9	3.3	-4.1
Hearing difficulty/problems: Yes	4.1	6.2	12.2	0.5	-3.5
Neck or shoulder pain in last month	4.1	5.8	11.3	3.4	0.5
Back pain experienced in last month	4.1	5.9	8.9	3.0	1.7
Illnesses of mother	4.0	5.0	5.1	2.2	2.3
Mouth/teeth dental problems: Bleeding gums	4.0	5.2	10.4	-0.2	-3.2
Medication: Ibuprofen (e.g. Nurofen)	3.9	4.9	5.6	2.4	2.1
Overall health rating	3.9	8.3	15.2	3.9	1.2
Ever highly irritable/argumentative for 2 days	3.8	4.6	8.0	2.8	1.1
Myopia	3.8	5.5	5.7	-2.4	-2.3
Primary Biliary Cirrhosis	3.7	5.3	7.5	2.7	-1.7
Pulse rate	3.7	6.2	8.7	1.9	-2.9
Health satisfaction	3.6	4.7	9.1	3.0	0.6
Crohns Disease (2012)	3.5	5.6	9.8	3.1	-1.2
Commuting to job workplace: Car/motor vehicle	3.5	4.0	7.3	-0.9	-2.7
Medication: Ventolin 100micrograms inhaler	3.4	4.4	4.8	2.0	2.2
Intelligence (Savage-Jansen 2018)	3.3	10.1	11.9	-3.4	-2.9
Worrier / anxious feelings	3.3	6.2	9.1	-1.8	-3.0
Angina (self-reported)	3.3	4.3	7.9	2.8	0.8
Medication: Ibuprofen	3.3	3.9	5.1	2.3	1.6
Supplements: Fish oil (including cod liver oil)	3.2	4.2	4.6	-2.2	-1.9
Major Depression (MDD)	3.1	3.8	7.5	2.7	-0.3
Smoking Status	3.1	7.4	9.8	3.1	2.2
Impedance of leg (right)	3.1	14.8	20.9	-4.6	-2.9
Mouth/teeth dental problems	3.1	4.8	9.6	0.2	3.1
Hayfever, allergic rhinitis or eczema	3.0	6.6	7.6	2.4	2.8
Ever had prostate specific antigen (PSA) test	3.0	3.4	5.7	-2.4	-1.1
Irritable Bowel Disease (IBD)	2.9	6.9	13.3	3.6	-0.7
Impedance of leg (left)	2.8	13.4	19.0	-4.4	-2.8
Heart attack/myocardial infarction (self-reported)	2.8	3.6	3.7	1.9	1.9
Blood Eosinophil Count	2.7	20.9	30.4	3.4	5.5
Angina	2.7	3.6	6.6	2.6	0.8
Noisy workplace	2.7	3.3	5.5	2.4	1.1
Breastfed as a baby	2.7	3.4	4.9	-2.2	-1.4
Heart disease (mother)	2.7	3.3	6.1	-0.7	-2.5
Medication: Metformin	2.6	3.6	5.2	1.4	-2.3
High blood pressure (mother)	2.6	3.6	7.0	-2.6	0.5
Birth weight	2.6	5.7	6.9	-2.6	-2.1
Diastolic blood pressure, automated reading	2.6	7.9	12.6	1.8	3.5
Type 2 Diabetes (T2D) (2012)	2.4	2.8	5.3	2.3	-0.5
Diabetes (mother)	2.4	3.1	6.2	0.1	-2.5
Number of live births	2.4	3.4	3.4	-1.8	-1.8
Comparative body size at age 10	2.4	6.5	9.7	-3.1	-1.8
Long-standing illness, disability or infirmity	2.4	3.7	5.7	2.4	1.3
Commuting to job workplace: Public transport	2.4	2.9	5.8	-0.1	2.4
Leg fat percentage (right)	2.3	8.2	14.9	1.2	-3.9
Average weekly fortified wine intake	2.2	2.5	5.1	0.0	2.2
Chest pain or discomfort	2.2	3.2	6.4	2.5	-0.1
Leg fat percentage (left)	2.2	8.0	13.0	1.7	-3.6
Medication: Co-codamol	2.1	2.4	4.8	2.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.1	2.6	5.1	2.2	0.2
Illnesses of father: None of the above (group 1)	2.1	2.5	4.2	-1.0	-2.0
HDL Cholesterol	2.0	3.4	6.1	-2.5	-0.8
Eye problems/disorders: Diabetes related eye disease	2.0	2.1	4.3	2.1	0.2
Taking other prescription medications	2.0	3.0	5.9	2.4	-0.3
Waist circumference	2.0	7.4	10.0	3.2	-2.2
Leg fat mass (left)	2.0	7.7	8.6	2.9	-2.6
Verbal and Numeric Reasoning (VNR)	1.9	4.5	4.5	-2.1	-2.1
Had menopause	1.9	2.3	2.3	1.5	1.5
Medication: Omeprazole	1.9	2.3	3.3	1.1	-1.8
Leg fat mass (right)	1.9	7.4	7.7	2.7	-2.8
Arm fat mass (left)	1.9	7.7	13.3	3.6	-1.5
Commuting to job workplace: Cycle	1.9	2.2	4.5	0.1	2.1
Impedance of whole body	1.9	9.9	15.6	-3.9	-2.0
Alzheimer’s Disease (in father)	1.8	2.0	2.8	1.7	1.0
Mean Putamen Volume	1.8	2.1	2.6	-1.6	1.2
Alcohol usually taken with meals	1.8	2.8	5.5	-2.3	-0.5
Arm fat mass (right)	1.8	7.5	12.2	3.5	-1.6
Number of full brothers	1.8	2.2	4.1	2.0	-0.6
Worry too long after embarrassment	1.8	3.1	4.2	-2.0	-1.4
Deep venous thrombosis (DVT) (self-reported)	1.8	2.4	4.1	-2.0	-0.8
Body mass index (BMI)	1.7	7.3	13.2	3.6	-1.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	2.6	1.4	1.6
Fluid intelligence score	1.7	3.5	4.0	-1.7	-2.0
Hip circumference	1.7	7.4	11.5	3.4	-1.8
Headache pain in last month	1.7	2.8	5.6	-0.2	-2.4
Body fat percentage	1.7	6.6	8.8	2.1	-3.0
Medication for pain relief, constipation, heartburn	1.7	3.0	5.2	-2.3	0.9
Whole body fat mass	1.7	7.0	8.8	3.0	-2.3
Leg fat-free mass (right)	1.7	9.2	17.8	4.2	0.7
Leg predicted mass (right)	1.7	9.3	18.0	4.2	0.8
Fasting Glucose	1.6	1.9	3.6	1.9	0.5
Triglycerides	1.6	2.7	4.8	2.2	0.7
Sensitivity / hurt feelings	1.6	2.8	4.6	-2.2	-1.0
Ever had hysterectomy (womb removed)	1.6	1.8	3.0	-1.7	-0.7
Leg predicted mass (left)	1.6	8.4	16.6	4.1	0.4
Trunk fat mass	1.6	6.9	8.1	2.9	-2.4
Heart attack	1.6	2.0	2.2	1.3	1.5
Weight	1.6	7.7	12.8	3.6	-1.6
Hair/balding pattern: Pattern 3	1.6	2.3	2.5	-1.5	-1.6
Blood clot in the leg (DVT)	1.6	2.1	3.5	-1.9	-0.9
Number of full sisters	1.6	1.9	1.9	1.4	-1.4
Loneliness, isolation	1.6	2.3	3.0	-1.7	1.2
Diabetes diagnosed by doctor	1.6	2.6	3.2	1.8	-1.4
Qualifications: nursing, teaching	1.6	2.5	4.5	-2.1	-0.7
Medication for cholesterol	1.6	2.5	4.8	-0.4	-2.2
Irritability	1.6	2.8	5.1	2.3	-0.7
Worry (Nagel 2018)	1.5	3.1	4.5	-1.3	-2.1
Leg fat-free mass (left)	1.5	8.2	16.3	4.0	0.3
Number of incorrect matches in round	1.5	2.6	3.8	-1.2	-1.9
Medication: Amlodipine	1.5	2.1	4.0	0.5	2.0
Emphysema/chronic bronchitis	1.5	1.7	2.7	0.8	1.6
Mineral and other dietary supplements	1.5	2.0	4.0	0.1	2.0
Medication: Blood pressure	1.5	2.8	3.1	-1.5	1.8
Medication: Bendroflumethiazide	1.5	2.2	2.6	-1.4	1.6
Medication: Paracetamol	1.5	2.3	2.5	1.6	-1.5
Schizophrenia vs Biploar Disorder	1.4	1.9	2.9	0.9	1.7
Vitamin and mineral supplements	1.4	1.9	2.7	1.1	1.6
Fed-up feelings	1.4	2.5	3.6	1.1	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.9	2.2	1.3	1.5
Age when periods started (menarche)	1.4	3.3	5.8	2.4	0.9
Arm fat percentage (right)	1.4	5.5	6.3	2.5	-2.2
Age at first live birth	1.4	2.6	4.2	-2.0	-1.0
Arm predicted mass (right)	1.4	7.0	13.9	3.7	0.4
Illnesses of father: Heart disease	1.4	2.0	3.8	2.0	0.2
Eye problems/disorders: Cataract	1.4	1.6	3.2	1.8	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.8	2.7	0.9	-1.6
Heel T-Score	1.3	10.7	19.0	-4.4	-1.6
Type 2 Diabetes (T2D) (2018)	1.3	2.4	3.4	1.2	-1.9
Trunk fat percentage	1.3	5.4	6.4	2.1	-2.5
Relative age voice broke	1.3	2.0	3.4	0.8	1.8
Father’s age at death	1.3	1.7	3.4	-1.9	0.0
Length of working week for main job	1.3	1.4	2.3	-0.7	-1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	2.0	3.4	-1.8	-0.8
Birth weight of first child	1.3	2.3	4.1	-0.8	-2.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.0	1.0	1.4
Arm fat percentage (left)	1.3	5.2	7.0	2.6	-1.9
Osteoarthritis (self-reported)	1.3	1.7	2.4	1.1	-1.5
Number of self-reported non-cancer illnesses	1.3	2.3	4.1	2.0	0.7
Ever taken oral contraceptive pill	1.3	1.5	2.7	0.5	-1.6
Arm fat-free mass (left)	1.3	6.6	13.0	3.6	-0.5
Body Mass Index (BMI) (2010)	1.2	1.7	3.3	-0.4	-1.8
Lupus	1.2	1.9	3.8	0.0	-1.9
BMI	1.2	6.9	12.0	3.5	-1.4
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.7	1.7	0.7
Impedance of arm (right)	1.2	5.8	8.8	-3.0	-1.7
Arm fat-free mass (right)	1.2	6.2	12.4	3.5	0.2
Mood swings	1.2	2.2	4.1	0.5	-2.0
Whole body water mass	1.2	6.7	13.4	3.7	0.2
Basal metabolic rate	1.2	6.6	13.1	3.6	-0.4
Pain experienced in last month	1.2	2.0	2.0	-1.4	1.4
Heart disease (siblings)	1.2	1.5	2.8	1.7	-0.4
Arm predicted mass (left)	1.2	6.3	12.4	3.5	-0.5
Rheumatoid Arthritis	1.1	1.6	1.7	-1.3	-1.2
Hand grip strength (right)	1.1	2.9	5.2	2.3	0.8
Qualifications: None of the above	1.1	2.3	2.5	1.4	1.6
Qualifications: A levels/AS levels or equivalent	1.1	2.4	4.0	-2.0	-0.8
Impedance of arm (left)	1.1	5.1	8.9	-3.0	-1.2
Whole body fat-free mass	1.1	6.6	13.1	3.6	0.2
Commuting to job workplace: Walk	1.1	1.1	1.4	0.9	1.2
Osteoporosis (self-reported)	1.1	1.4	2.8	-1.7	-0.3
Ovarian Cancer	1.0	1.3	1.3	1.2	1.2
Blood White Count	1.0	7.5	13.3	3.6	1.3
Supplements: Glucosamine	1.0	1.2	2.1	0.6	-1.5
Medication: Paracetamol	1.0	1.7	1.9	1.4	-1.2
Eye problems/disorders: None of the above	1.0	1.2	2.0	-1.4	0.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.3	1.1	-1.2
Alcohol drinker status: Never	1.0	1.1	2.1	-0.5	-1.4
Number of operations (self-reported)	1.0	1.5	2.9	0.4	-1.7
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	2.4	1.6	-0.6
Pain all over the body in last month	0.9	1.0	1.1	1.1	-0.9
Diabetes (self-reported)	0.9	1.4	1.5	1.1	-1.2
Alcohol intake versus 10 years previously	0.9	1.4	1.5	1.2	1.1
Supplements: Vitamin C	0.9	1.0	1.1	-1.0	-1.1
Illnesses of siblings: Diabetes	0.9	1.1	1.4	0.9	-1.2
Breast Cancer	0.8	2.0	3.1	-0.9	1.7
Waist Hip Ratio (WHR)	0.8	3.5	6.7	-0.5	-2.6
Relative age of first facial hair	0.8	1.7	1.7	1.3	1.3
Severe depression (siblings)	0.8	0.9	1.2	-0.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.6	-1.3	-0.3
Nervous feelings	0.8	1.5	1.9	-1.1	-1.4
Hearing difficulty/problems with background noise	0.8	1.3	2.2	-0.6	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.2	-1.2	-1.5
Trunk predicted mass	0.8	4.4	8.7	3.0	-0.0
Tense / ‘highly strung’	0.8	1.4	2.5	-0.5	-1.6
Mean time to correctly identify matches	0.8	1.6	1.7	-1.3	-1.2
Age at last live birth	0.8	1.2	1.8	-1.4	-0.7
Illness, injury, bereavement, stress in last 2 years	0.8	0.9	1.0	-1.0	0.9
Knee pain experienced in last month	0.8	1.2	2.3	1.5	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.2	-1.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.0	1.0	1.0
Unable to work because of sickness or disability	0.8	1.0	1.1	0.9	1.1
Supplements: Calcium	0.8	0.9	1.5	1.2	-0.6
Alzheimer’s Disease (in mother)	0.7	0.9	1.5	-1.2	-0.4
Number of treatments/medications taken	0.7	1.3	2.1	1.4	-0.7
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.9	-0.3	-1.4
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	2.1	-1.1	-1.5
Serious illness, injury or assault to yourself	0.7	0.8	1.2	1.1	-0.7
Chronic bronchitis/emphysema (father)	0.7	0.8	1.2	0.6	1.1
Trunk fat-free mass	0.7	4.2	8.3	2.9	-0.1
Falls in the last year	0.7	1.0	1.7	-0.4	-1.3
Pulse wave reflection index	0.7	0.9	1.8	-1.3	-0.1
Smoking status: Previous	0.7	1.0	1.1	-1.1	-0.9
Medication: Lisinopril	0.7	0.9	1.8	-1.3	-0.3
Ever depressed for a whole week	0.7	0.9	1.8	-0.1	-1.3
Reaction Time	0.6	1.1	1.2	-1.0	-1.1
Hypothyroidism (self reported)	0.6	1.4	2.5	1.6	0.5
Hand grip strength (left)	0.6	1.5	3.0	1.7	0.2
Sitting height	0.6	3.9	6.1	1.3	-2.5
Medication: Ramipril	0.6	0.8	1.4	1.2	0.4
Medication: Cholesterol lowering	0.6	0.9	1.8	-0.0	-1.3
Gout (self-reported)	0.6	0.8	1.6	0.0	1.3
Average weekly red wine intake	0.6	0.9	1.8	-0.1	-1.4
Guilty feelings	0.6	1.0	1.2	-0.8	-1.1
LDL Cholesterol	0.5	0.8	1.5	-0.4	-1.2
Cardiovascular Disease	0.5	1.7	1.7	-1.3	1.3
Chronotype (morning person)	0.5	1.2	2.4	-1.6	-0.0
Diabetes (father)	0.5	0.6	1.0	1.0	0.4
Stomach or abdominal pain in last month	0.5	0.6	0.8	0.6	-0.9
Medication: Lansoprazole	0.5	0.6	0.9	0.5	1.0
Loud music exposure frequency	0.5	0.6	1.0	0.3	1.0
Qualifications: College or University degree	0.5	1.5	2.0	-1.4	-1.0
Suffer from ‘nerves’	0.5	0.7	1.2	-1.1	-0.5
Medication: Aspirin	0.5	0.6	1.2	0.3	-1.1
Basal cell carcinoma (self-reported)	0.5	0.6	0.6	-0.7	-0.8
Bipolar Disorder (2018)	0.4	0.7	1.2	-0.4	-1.1
Prostate Cancer	0.4	0.5	0.7	0.6	0.8
Blood Red Count	0.4	3.5	6.0	2.4	1.0
Qualifications: CSEs or equivalent	0.4	0.5	0.9	-0.3	1.0
High blood pressure	0.4	1.2	1.3	-1.1	1.0
Had other major operations	0.4	0.5	1.0	-0.0	-1.0
Illnesses of siblings	0.4	0.6	1.0	-1.0	0.3
Neuroticism score	0.4	0.9	1.1	-0.8	-1.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	1.4	1.2	0.2
High blood pressure (siblings)	0.4	0.5	0.8	0.5	0.9
Comparative height size at age 10	0.4	2.3	3.8	-0.9	-1.9
Hypertension (Self-reported)	0.4	1.1	1.8	-0.6	1.3
Medication: Gliclazide	0.4	0.4	0.8	0.9	0.1
Average weekly champagne plus white wine intake	0.4	0.6	0.7	-0.8	0.7
Miserableness	0.4	0.7	0.8	0.9	0.8
Wears glasses or contact lenses	0.4	0.5	1.0	1.0	-0.1
Mother’s age at death	0.4	0.5	1.0	-1.0	0.3
Medication: Atorvastatin	0.4	0.5	0.9	-0.2	-0.9
Illnesses of father: High blood pressure	0.4	0.5	0.9	-0.3	0.9
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.4	0.2	-1.5
Depressed Affect (Nagel 2018)	0.3	0.6	0.8	0.9	0.6
Age at First Birth	0.3	0.4	0.9	-0.9	0.1
Bipolar Disorder (2011)	0.3	0.2	0.4	0.6	-0.3
HbA1C	0.3	0.3	0.5	0.7	0.5
Ulcerative Colitis	0.3	0.4	0.6	-0.4	-0.8
Average weekly spirits intake	0.3	0.3	0.4	0.5	-0.6
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.7	-0.8	0.1
Medication for hormone replacement therapy	0.3	0.3	0.4	0.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.4	0.5	-0.6
Hair/balding pattern: Pattern 4	0.3	0.8	1.2	0.6	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.6	-0.8	0.4
Medication: Allopurinol	0.3	0.3	0.4	-0.6	-0.5
Alcohol intake frequency.	0.3	0.6	0.7	0.8	-0.8
Medication: Aspirin	0.3	0.4	0.5	0.5	-0.7
Friendships satisfaction	0.3	0.4	0.6	-0.3	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	0.6	0.8	-0.1
Ever smoked	0.3	0.5	0.6	0.6	0.8
Risk taking	0.3	0.4	0.4	-0.6	-0.6
Fractured/broken bones in last 5 years	0.3	0.4	0.8	0.2	0.9
Cholesterol lowering medication	0.3	0.4	0.9	0.1	0.9
Depression (Nagel 2018)	0.2	0.4	0.7	0.2	0.8
Neuroticism (Nagel 2018)	0.2	0.4	0.5	-0.6	-0.7
Schizophrenia (2018)	0.2	0.4	0.5	-0.7	0.6
Alzheimer’s Disease (including proxy)	0.2	0.3	0.4	-0.5	-0.7
Ulcerative Colitis (UC)	0.2	0.4	0.5	0.7	-0.6
Blood Platelet Count	0.2	2.2	4.3	-2.1	0.2
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	-0.0
Time employed in main current job	0.2	0.3	0.5	-0.2	0.7
Happiness	0.2	0.3	0.3	0.4	-0.6
Prospective memory result	0.2	0.3	0.5	0.7	0.2
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	0.7	0.0
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.5	0.3	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	0.6	-0.3
Number of children fathered	0.2	0.2	0.3	-0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.3	-0.5	-0.5
Pulse wave peak to peak time	0.2	0.2	0.4	-0.6	-0.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.4	-0.1	0.6
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.9	0.2
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	-0.3	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	0.0	0.6
Breast cancer (self-reported)	0.2	0.3	0.6	0.1	-0.8
Financial situation satisfaction	0.2	0.2	0.4	0.6	0.3
Tinnitus: Yes, now most or all of the time	0.2	0.2	0.5	0.1	-0.7
Alcohol drinker status: Previous	0.2	0.2	0.4	0.6	-0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	0.7	-0.8	-0.2
Neuroticism (2016)	0.1	0.1	0.2	-0.0	0.4
Schizophrenia (2014)	0.1	0.2	0.4	-0.2	0.6
Height	0.1	2.2	2.9	1.3	-1.7
Tanning	0.1	1.7	2.1	1.4	1.2
Supplements: Zinc	0.1	0.1	0.1	0.2	-0.3
Multivitamins +/- minerals	0.1	0.2	0.3	-0.1	-0.6
Medication: Atenolol	0.1	0.1	0.3	-0.0	-0.5
Medication: Levothyroxine sodium	0.1	0.2	0.2	0.4	-0.4
Medication: Simvastatin	0.1	0.1	0.2	0.5	-0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.4	0.6	0.1
Depression (self-reported)	0.1	0.2	0.2	0.5	-0.2
Standing height	0.1	0.5	0.8	0.5	-0.9
Glaucoma (self-reported)	0.1	0.1	0.2	0.4	-0.3
Medication: Seretide 50 evohaler	0.1	0.1	0.1	0.4	0.2
Had major operations	0.1	0.1	0.2	-0.5	0.3
Family relationship satisfaction	0.1	0.1	0.1	-0.3	0.1
Age started oral contraceptive pill	0.1	0.1	0.1	0.4	-0.1
Neuroticism	0.0	0.0	0.1	0.1	-0.3
Hair Pigment	0.0	0.0	0.1	0.0	0.3
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.1	0.0
Past tobacco smoking	0.0	0.0	0.0	-0.1	-0.1
Financial difficulties in last 2 years	0.0	0.0	0.1	0.2	0.1
Lung cancer (father)	0.0	0.0	0.0	-0.0	0.0
Qualifications: O levels/GCSEs or equivalent	0.0	0.0	0.1	-0.1	0.3
Medication: Blood pressure	0.0	0.1	0.1	0.4	0.1
Migraine (self-reported)	0.0	0.0	0.0	0.0	0.0
Hearing aid user	0.0	0.0	0.0	-0.0	-0.0
High cholesterol (Self-reported)	0.0	0.0	0.0	0.1	0.2

Hub : Genes

NDST2

Models

Trait associations