Hub : Genes

DUSP8P5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.2487	0.0867	0.00140	0.113	NA	0.039	NA	0.167	7.7e-05	NA	0.015	NA	1.3e-06
2	GTEx	Artery Tibial	0.0904	0.0500	0.00730	0.027	NA	0.030	NA	0.027	3.1e-03	NA	0.002	NA	3.0e-03
3	GTEx	Heart Left Ventricle	0.1269	0.0590	0.00042	0.040	NA	0.028	NA	0.035	3.5e-03	NA	0.012	NA	5.8e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	1.0	-1.0	-0.1	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.5	0.9	0.8	0.9	0.3
Depressed Affect (Nagel 2018)	0.6	1.4	4.0	0.1	-2.0	0.2
Depression (Nagel 2018)	0.1	0.2	0.4	0.3	-0.6	0.4
Intelligence (Savage-Jansen 2018)	1.2	3.7	10.1	0.5	3.2	0.8
Neuroticism (Nagel 2018)	0.1	0.2	0.2	-0.5	-0.4	0.5
Schizophrenia (2018)	1.0	2.0	3.3	1.8	1.3	1.0
Schizophrenia vs Biploar Disorder	0.6	0.8	1.6	1.3	-0.7	0.6
Worry (Nagel 2018)	0.2	0.4	1.2	-1.1	0.3	-0.2
Alzheimer’s Disease (in mother)	1.4	1.7	2.1	1.4	1.3	1.1
Alzheimer’s Disease (in father)	1.8	2.0	3.4	-1.0	-1.9	-1.2
Alzheimer’s Disease (including proxy)	0.0	0.0	0.1	0.1	0.3	-0.0
Crohns Disease (2017)	11.9	26.1	33.7	-4.4	-5.8	-5.1
Irritable Bowel Disease (IBD)	5.2	12.4	14.3	-3.1	-3.8	-3.7
Ulcerative Colitis (UC)	0.3	0.6	1.1	-0.8	-0.2	-1.1
Major Depression (MDD)	3.9	4.7	6.4	-2.5	-1.3	-2.5
Reaction Time	0.5	1.0	3.0	1.7	-0.1	0.2
Verbal and Numeric Reasoning (VNR)	0.6	1.4	3.6	-0.0	1.9	0.6
Breast Cancer	2.2	5.2	12.1	1.9	0.1	3.5
Ovarian Cancer	0.9	1.2	2.9	0.8	-1.7	-0.3
Prostate Cancer	0.2	0.3	0.7	-0.9	0.3	-0.1
Age at First Birth	0.7	1.0	1.8	1.3	0.3	1.1
Bipolar Disorder (2011)	1.2	1.2	1.7	-1.3	-1.1	-0.7
Body Mass Index (BMI) (2010)	0.9	1.2	2.4	-1.6	0.6	-0.9
Coronary Artery Disease (CAD)	4.2	5.0	13.9	-0.7	-3.7	-0.7
Crohns Disease (2012)	6.5	10.5	12.5	-2.9	-3.2	-3.5
Mean Putamen Volume	4.0	4.6	7.2	2.1	1.4	2.7
Fasting Glucose	1.9	2.3	5.6	-0.8	-2.4	-0.9
HbA1C	0.2	0.2	0.5	-0.3	-0.3	-0.7
HDL Cholesterol	1.4	2.3	3.0	1.7	1.4	1.3
LDL Cholesterol	0.7	1.1	1.8	-0.9	0.8	-1.3
Lupus	0.8	1.2	2.2	-0.4	1.1	-1.5
Neuroticism (2016)	0.1	0.2	0.5	0.2	-0.2	0.7
Primary Biliary Cirrhosis	7.7	11.0	20.4	-3.5	-0.8	-4.5
Rheumatoid Arthritis	0.7	0.9	2.5	0.2	1.6	0.6
Schizophrenia (2014)	0.4	0.9	2.0	1.4	0.8	0.5
Triglycerides	1.8	3.0	4.4	-2.1	-2.0	-0.8
Type 2 Diabetes (T2D) (2012)	4.3	5.0	6.8	-2.2	-2.6	-1.8
Ulcerative Colitis	0.3	0.4	1.0	-0.1	1.0	-0.3
Blood Eosinophil Count	0.2	1.8	4.2	-0.2	-2.0	1.1
Blood Platelet Count	0.4	4.6	8.4	-1.0	2.9	2.1
Blood Red Count	0.3	2.5	3.8	-2.0	-1.4	-1.3
Blood White Count	1.0	7.5	13.1	-3.6	-1.7	-2.5
Heel T-Score	2.1	17.1	28.9	3.0	5.4	3.7
BMI	1.6	9.3	17.3	-4.2	-0.6	-3.2
Height	0.7	12.9	15.9	-2.8	-3.9	-4.0
Waist Hip Ratio (WHR)	0.6	2.8	4.0	-1.3	1.6	-2.0
Systolic Blood Pressure	5.4	26.8	63.7	3.8	1.5	8.0
Smoking Status	1.6	3.8	8.6	-1.1	-2.9	-1.2
Allergy or Eczema	1.4	3.7	11.0	0.1	-3.3	0.1
Cardiovascular Disease	2.1	7.0	13.2	1.3	2.5	3.6
Hypothyroidism (self reported)	1.4	3.1	6.2	-1.5	-2.5	-0.9
Respiratory disease	1.2	2.7	7.9	0.2	-2.8	0.4
Type 2 Diabetes (T2D) (2018)	2.0	3.7	6.2	-2.5	-1.1	-2.0
Lung FEV1/FVC ratio	1.0	4.8	14.1	-0.7	3.8	-0.1
Lung FVC	5.8	29.4	54.7	4.0	7.4	4.2
Neuroticism	0.3	0.8	2.1	-0.4	-1.4	0.1
Chronotype (morning person)	0.8	1.9	3.0	1.6	0.4	1.7
Hair Pigment	0.0	0.4	0.8	0.5	-0.0	0.9
Tanning	0.1	0.6	1.7	-0.3	-1.3	-0.4
Hand grip strength (left)	1.8	4.8	7.8	-2.8	-2.1	-1.5
Number of treatments/medications taken	1.4	2.5	3.2	-1.5	-1.8	-1.5
Average weekly spirits intake	0.3	0.4	0.8	-0.9	-0.6	-0.4
Sensitivity / hurt feelings	0.9	1.5	1.6	1.1	1.3	1.3
Frequency of depressed mood in last 2 weeks	0.7	0.9	1.4	-1.1	-0.4	-1.2
Hearing difficulty/problems: Yes	3.1	4.7	12.5	-1.1	0.5	-3.5
Relative age of first facial hair	0.3	0.5	1.0	1.0	-0.7	-0.4
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	2.4	-1.2	-1.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.1	0.8	1.0	0.5
Ever had hysterectomy (womb removed)	1.8	2.0	3.5	1.2	1.9	1.0
Systolic blood pressure, automated reading	2.8	8.1	21.3	1.6	-0.6	4.6
Eye problems/disorders: Diabetes related eye disease	2.5	2.8	4.1	-1.4	-2.0	-1.5
Angina	1.7	2.3	2.7	-1.6	-1.2	-1.6
Medication for hormone replacement therapy	0.1	0.2	0.4	0.7	0.2	0.1
Vitamin and mineral supplements	0.3	0.4	0.8	0.6	-0.5	0.9
Supplements: Zinc	0.5	0.6	0.9	-0.9	-0.6	-0.7
Medication: Co-codamol	3.1	3.6	8.2	-1.0	-2.9	-1.3
Medication: Metformin	4.7	6.7	9.9	-3.1	-1.0	-3.0
Diabetes (father)	0.3	0.4	1.1	-1.1	-0.1	0.2
Diabetes (mother)	1.0	1.3	2.2	-1.5	0.4	-1.3
Severe depression (siblings)	1.7	1.9	5.2	-0.7	2.3	-0.2
Pack years adult smoking proportion	3.7	5.7	7.5	-2.5	-1.9	-2.7
Impedance of leg (right)	0.7	3.6	4.2	1.8	2.0	1.8
Leg fat-free mass (left)	1.9	9.9	12.7	-3.4	-2.3	-3.6
Trunk fat percentage	2.2	8.9	13.6	-3.7	0.4	-3.6
Hand grip strength (right)	1.8	5.0	7.2	-2.2	-2.7	-1.7
Townsend deprivation index at recruitment	1.4	2.0	5.7	-0.0	-2.4	-0.5
Current tobacco smoking	2.1	3.4	6.7	-1.4	-2.6	-1.3
Average weekly fortified wine intake	1.7	2.0	5.4	0.6	0.5	2.3
Maternal smoking around birth	1.4	2.1	4.4	-1.2	-2.1	-0.5
Fed-up feelings	0.6	1.1	2.1	0.7	-1.5	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.7	0.2	-1.3	0.1
Relative age voice broke	0.9	1.4	3.2	1.8	-0.1	1.0
Taking other prescription medications	4.7	7.2	10.6	-2.6	-3.3	-2.0
Age when periods started (menarche)	0.8	1.9	2.3	-1.4	-1.5	-1.2
Bilateral oophorectomy (both ovaries removed)	0.0	0.1	0.1	-0.4	0.1	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	3.8	-0.4	1.9	0.3
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.2	0.7	1.1	0.7
Qualifications: CSEs or equivalent	1.2	1.6	2.8	1.0	1.0	1.7
Serious illness, injury or assault to yourself	1.9	2.3	3.1	-1.6	-1.0	-1.8
High blood pressure	1.3	3.6	6.0	0.9	2.0	2.5
Hayfever, allergic rhinitis or eczema	1.3	2.8	8.5	0.1	-2.9	0.0
Multivitamins +/- minerals	0.3	0.4	0.8	-0.9	-0.1	-0.6
Stomach or abdominal pain in last month	2.1	2.6	5.2	-2.3	0.9	-1.3
Supplements: Glucosamine	1.6	2.1	4.1	-0.8	-2.0	-1.2
Diverticular disease/diverticulitis (self-reported)	0.7	0.8	1.8	-0.6	1.3	-0.4
Medication: Atenolol	0.4	0.5	1.0	-1.0	-0.6	-0.2
Medication: Levothyroxine sodium	0.7	1.1	2.4	-0.5	-1.5	-0.9
Sitting height	1.4	9.9	13.9	-3.7	-1.9	-3.5
Chronic bronchitis/emphysema (father)	0.2	0.3	0.8	0.1	-0.3	0.9
High blood pressure (mother)	5.1	7.2	10.7	1.8	2.7	3.3
Body mass index (BMI)	2.5	10.7	18.3	-4.3	-0.7	-3.7
Impedance of leg (left)	0.8	3.9	5.1	1.8	2.3	1.8
Leg predicted mass (left)	1.8	9.7	12.3	-3.4	-2.3	-3.5
Trunk fat mass	3.0	12.8	19.6	-4.4	-0.5	-4.3
Waist circumference	3.7	13.4	20.2	-4.5	-0.5	-4.4
Number of incorrect matches in round	0.2	0.4	0.6	0.2	0.8	-0.7
Past tobacco smoking	0.2	0.3	0.6	-0.5	0.8	-0.2
Alcohol usually taken with meals	1.6	2.5	3.9	2.0	1.5	1.2
Nervous feelings	0.1	0.3	0.4	-0.7	0.6	0.0
Frequency of tenseness / restlessness in last 2 weeks	3.0	4.7	5.6	-2.2	-2.0	-2.4
Hearing difficulty/problems with background noise	0.6	0.9	2.5	1.6	0.3	-0.2
Hair/balding pattern: Pattern 2	3.0	3.8	5.5	2.2	-1.0	2.3
Had menopause	0.4	0.5	1.1	-0.2	-1.1	-0.5
Had other major operations	0.6	0.7	1.6	-0.6	-1.3	-0.5
Forced vital capacity (FVC)	1.6	6.1	12.9	1.8	3.6	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	6.4	-0.2	2.5	0.5
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	2.2	-1.0	-1.5	-0.7
Qualifications: None of the above	0.4	0.8	1.8	1.3	-0.8	0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	-0.4	-0.8	0.1
Mouth/teeth dental problems	2.5	3.8	5.8	2.4	1.0	2.1
Heart attack	0.1	0.2	0.4	-0.6	0.0	0.3
Allergy	1.8	4.2	12.5	0.2	3.5	0.4
Pain all over the body in last month	1.9	2.1	3.7	-1.3	-0.9	-1.9
Diabetes (self-reported)	2.1	3.2	4.2	-2.1	-1.5	-1.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	3.7	-0.0	-1.9	0.1
Medication: Ramipril	0.3	0.3	0.4	-0.6	-0.6	-0.5
Medication: Simvastatin	0.2	0.3	0.9	-0.3	-0.9	-0.1
Fluid intelligence score	1.0	2.0	4.7	-1.2	2.2	0.4
Illnesses of siblings	0.4	0.6	0.8	0.7	0.9	0.6
Neuroticism score	0.1	0.1	0.3	-0.5	-0.3	0.2
Weight	3.0	14.9	21.5	-4.6	-1.6	-4.6
Impedance of arm (right)	0.7	3.4	5.4	2.3	2.0	0.9
Arm fat percentage (right)	2.3	9.1	13.9	-3.7	0.6	-3.6
Trunk fat-free mass	1.4	8.3	10.2	-3.1	-2.3	-3.2
Hip circumference	3.2	13.7	21.1	-4.6	-1.2	-4.3
Time employed in main current job	0.3	0.4	1.1	1.1	0.2	0.1
Alcohol intake versus 10 years previously	0.8	1.1	3.3	-0.1	-1.8	-0.3
Father’s age at death	1.3	1.8	2.8	0.9	1.7	1.3
Worrier / anxious feelings	0.7	1.3	2.5	-1.6	0.5	-1.1
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.9	10.8	-1.2	-3.3	-2.3
Falls in the last year	0.4	0.5	0.7	0.2	0.8	-0.8
Hair/balding pattern: Pattern 3	0.3	0.4	1.3	0.2	1.1	0.0
Number of live births	0.6	0.8	1.1	1.1	1.0	0.5
Forced expiratory volume in 1-second (FEV1)	3.1	10.5	27.2	1.6	5.2	1.3
Pulse rate	7.4	12.5	22.4	-3.7	-1.2	-4.7
Happiness	1.2	1.5	3.2	-1.0	-0.5	-1.8
Noisy workplace	0.9	1.1	1.1	-1.1	-1.0	-1.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.4	0.6	0.6	0.5
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	0.7	-0.8	-0.4	-0.8
Mouth/teeth dental problems: Dentures	0.4	0.6	1.4	-0.4	-1.2	-0.5
Asthma	1.9	3.8	9.5	-0.9	-3.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.3	-0.3	-1.0	-1.1
Medication: Cholesterol lowering	0.5	0.7	1.2	-1.1	0.7	-0.8
Depression (self-reported)	0.5	0.6	1.3	-1.2	-0.3	-0.6
Medication: Lansoprazole	0.1	0.2	0.4	0.0	-0.1	0.7
Prospective memory result	0.6	0.7	1.5	-1.2	-0.8	0.1
Lung cancer (father)	0.1	0.1	0.2	0.4	0.1	0.3
Illnesses of mother	2.3	2.9	8.1	-0.2	-2.8	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.4	24.3	1.4	4.9	1.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.2	-0.4	0.2	-0.3
Impedance of arm (left)	1.0	4.6	7.2	2.7	2.2	1.3
Arm fat mass (right)	3.0	12.3	18.9	-4.3	-0.8	-4.2
Trunk predicted mass	1.5	8.4	10.4	-3.1	-2.3	-3.2
Standing height	0.4	3.9	5.9	-1.2	-2.1	-2.4
Length of working week for main job	0.6	0.7	1.4	-0.4	1.2	-0.7
Exposure to tobacco smoke at home	5.2	5.8	7.4	-2.0	-2.5	-2.7
Breastfed as a baby	0.3	0.4	0.5	0.5	0.7	0.6
Tense / ‘highly strung’	0.7	1.2	2.5	-1.6	-0.6	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.9	0.0	1.4	1.2
Hair/balding pattern: Pattern 4	0.7	1.8	3.1	-1.8	-0.3	-1.4
Birth weight of first child	0.9	1.7	2.5	-1.6	-0.4	-1.6
Peak expiratory flow (PEF)	1.4	3.3	8.4	0.9	2.9	0.8
Pulse wave reflection index	1.7	2.0	3.1	1.8	0.7	1.6
Ever highly irritable/argumentative for 2 days	3.4	4.1	7.3	-1.9	-2.7	-1.2
Loud music exposure frequency	0.7	0.7	1.9	1.4	-0.3	0.4
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.6	0.3	-0.5	0.8
Mouth/teeth dental problems: Bleeding gums	2.2	2.8	4.7	-2.2	-1.1	-1.6
Blood clot in the leg (DVT)	2.8	3.6	4.2	2.0	2.0	1.6
Medication: Paracetamol	1.7	2.9	5.6	-1.3	-1.1	-2.4
Headache pain in last month	1.6	2.7	6.2	-1.3	-0.4	-2.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.9	0.4	-0.9	0.2
Glaucoma (self-reported)	0.4	0.5	0.8	-0.8	-0.9	-0.2
Gout (self-reported)	0.2	0.3	0.6	0.4	0.2	0.8
Hypothyroidism/myxoedema (self-reported)	1.5	3.0	7.2	-0.8	-2.7	-1.0
Medication: Amlodipine	1.4	2.0	3.5	0.1	1.6	1.9
Medication: Ventolin 100micrograms inhaler	1.5	2.0	5.0	0.8	-2.2	0.5
Birth weight	0.5	1.0	2.2	0.9	1.5	-0.0
Chronic bronchitis/emphysema (mother)	0.9	1.1	1.6	-0.6	-1.2	-1.3
High blood pressure (siblings)	0.4	0.6	0.9	0.3	-1.0	0.8
Forced vital capacity (FVC), Best measure	1.6	5.8	12.1	1.6	3.5	1.6
Body fat percentage	2.5	9.9	16.1	-4.0	0.6	-3.6
Leg fat percentage (right)	2.8	10.3	18.5	-4.3	0.9	-3.4
Arm fat-free mass (right)	1.7	8.9	11.7	-3.4	-2.4	-3.0
Exposure to tobacco smoke outside home	5.1	6.8	8.6	-2.1	-2.7	-2.9
Comparative body size at age 10	2.2	6.0	15.9	1.1	4.0	1.0
Number of full brothers	3.6	4.5	6.2	-2.2	-1.6	-2.5
Worry too long after embarrassment	0.5	0.8	1.4	-0.5	0.9	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.3	0.1	1.0
Wheeze or whistling in the chest in last year	2.6	4.7	6.3	-2.0	-2.5	-1.9
Number of children fathered	0.2	0.3	0.5	-0.3	0.7	0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.2	0.1	-0.4
Age at first live birth	0.1	0.2	0.3	0.4	0.5	0.4
Pulse wave peak to peak time	0.0	0.0	0.1	0.2	-0.3	0.0
Health satisfaction	4.1	5.3	5.9	-2.4	-2.3	-2.1
Shortness of breath walking on level ground	1.7	2.1	5.2	-0.9	-2.3	0.1
Qualifications: College or University degree	0.4	1.2	2.8	-0.9	1.7	0.1
Eye problems/disorders: None of the above	2.0	2.4	3.3	1.8	1.1	1.6
Mouth/teeth dental problems: Loose teeth	3.1	3.6	4.7	-1.6	-2.2	-1.9
Emphysema/chronic bronchitis	0.9	1.0	2.0	0.6	-1.4	0.8
Medication for pain relief, constipation, heartburn	3.3	5.6	8.8	2.6	1.2	3.0
Neck or shoulder pain in last month	4.6	6.5	8.6	-2.3	-2.4	-2.9
Medication: Blood pressure	0.1	0.2	0.5	-0.7	0.3	-0.0
Angina (self-reported)	2.6	3.4	3.8	-2.0	-1.6	-1.9
Migraine (self-reported)	0.1	0.2	0.2	-0.3	-0.4	-0.5
Medication: Ibuprofen	0.9	1.0	1.6	-0.3	-1.2	-1.3
Medication: Allopurinol	0.3	0.4	1.0	-0.2	1.0	0.3
Medication: Omeprazole	2.7	3.3	4.6	-2.1	-0.8	-2.1
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.5	-0.0	0.2
Mean time to correctly identify matches	0.6	1.1	3.4	1.8	-0.0	0.2
Heart disease (mother)	0.5	0.6	1.1	-0.7	0.3	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	3.2	-1.0	-1.8	-1.2
Whole body fat mass	2.9	12.0	19.6	-4.4	-0.5	-4.0
Leg fat mass (right)	3.2	12.4	21.2	-4.6	-0.6	-4.0
Arm predicted mass (right)	1.9	9.9	13.2	-3.6	-2.7	-3.1
Pulse rate, automated reading	8.6	27.8	43.9	-5.8	-2.5	-6.6
Alcohol intake frequency.	0.3	0.7	0.9	-0.9	-0.7	-0.8
Comparative height size at age 10	0.4	2.2	2.7	-1.4	-1.4	-1.6
Number of full sisters	2.6	3.2	4.6	-0.6	-2.1	-2.1
Suffer from ‘nerves’	0.3	0.5	0.8	0.2	0.9	0.9
Overall health rating	3.5	7.6	11.1	-2.4	-3.3	-2.4
Chest pain or discomfort	4.1	6.0	6.2	-2.4	-2.5	-2.5
Had major operations	0.6	0.7	1.5	1.2	0.6	0.5
Age at last live birth	0.1	0.1	0.2	0.2	0.4	0.2
Family relationship satisfaction	0.2	0.2	0.4	0.7	-0.3	0.1
Leg pain on walking	3.8	4.8	5.9	-1.9	-2.4	-2.2
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.4	1.1	1.1	0.2	0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.6	-0.8	-0.2	-0.7
Illness, injury, bereavement, stress in last 2 years	2.0	2.4	3.2	1.8	1.5	1.3
Medication: Aspirin	0.9	1.2	3.1	-1.8	-0.0	-0.8
Supplements: Vitamin C	1.4	1.6	4.6	0.3	2.1	-0.5
Knee pain experienced in last month	1.8	2.7	5.9	-0.6	-1.4	-2.4
Hypertension (Self-reported)	1.1	3.0	5.9	0.6	1.6	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.1	-0.9	-0.1
Illnesses of father: Heart disease	1.3	1.8	2.5	-1.6	-1.0	-1.4
Illnesses of siblings: Diabetes	1.2	1.4	2.1	-0.9	-1.2	-1.4
Smoking status: Previous	0.3	0.5	0.8	0.9	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.7	-0.5	-1.3	-0.7
Whole body fat-free mass	1.7	9.8	11.8	-3.4	-2.5	-3.4
Leg fat-free mass (right)	1.6	8.7	11.2	-3.1	-2.3	-3.3
Arm fat percentage (left)	2.2	8.6	13.8	-3.7	0.6	-3.4
Average weekly red wine intake	0.6	0.9	1.3	-1.1	0.6	-1.0
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	0.1	1.2	-0.9
Mood swings	1.4	2.5	3.1	-1.3	-1.7	-1.8
Loneliness, isolation	2.4	3.3	6.1	1.5	1.2	2.5
Long-standing illness, disability or infirmity	1.2	1.9	5.1	-0.7	-2.2	-0.4
Ever had bowel cancer screening	1.0	1.2	1.7	1.3	1.0	1.0
Diabetes diagnosed by doctor	3.7	6.1	7.2	-2.7	-2.0	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.6	0.8	0.6	0.6
Friendships satisfaction	0.6	0.7	1.5	-0.7	0.2	-1.2
Qualifications: nursing, teaching	0.5	0.8	1.3	0.8	0.6	1.1
Commuting to job workplace: Walk	0.1	0.1	0.2	0.5	-0.4	-0.1
Eye problems/disorders: Cataract	2.9	3.3	4.5	-1.9	-1.4	-2.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.8	0.4	1.3	0.8
Medication for cholesterol	1.0	1.5	3.5	-1.0	0.5	-1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.7	-0.7	1.3	-0.3
Back pain experienced in last month	1.8	2.6	6.6	-0.3	-2.6	-1.0
Mineral and other dietary supplements	0.8	1.1	2.5	0.8	0.3	1.6
Breast cancer (self-reported)	0.7	0.8	1.6	-0.8	0.5	-1.3
Asthma (self-reported)	1.6	3.3	8.3	-0.7	-2.9	-1.0
Osteoporosis (self-reported)	0.4	0.4	0.8	0.9	-0.4	0.6
Osteoarthritis (self-reported)	3.2	4.2	5.5	-2.3	-2.2	-1.5
Medication: Aspirin	1.0	1.3	3.6	-1.9	-0.1	-0.6
Medication: Gliclazide	0.1	0.2	0.5	-0.7	-0.1	-0.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.5	0.0	0.5	-1.2
Smoking status: Current	2.8	4.5	9.4	-1.5	-3.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	5.4	11.3	21.1	2.3	4.6	2.7
Whole body water mass	1.8	10.0	11.9	-3.4	-2.5	-3.5
Leg predicted mass (right)	1.7	8.9	11.5	-3.1	-2.3	-3.4
Arm fat mass (left)	3.1	12.7	19.7	-4.4	-0.9	-4.2
Number of self-reported non-cancer illnesses	1.9	3.3	5.8	-1.7	-2.4	-1.1
Average weekly champagne plus white wine intake	0.5	0.7	1.1	1.1	0.5	0.8
Miserableness	0.4	0.8	1.1	1.0	-1.1	0.3
Guilty feelings	0.0	0.0	0.1	-0.3	0.1	-0.2
Wears glasses or contact lenses	2.0	2.3	4.0	-2.0	-0.5	-1.7
Ever taken oral contraceptive pill	2.3	2.6	3.8	-1.9	-0.4	-1.9
Hearing aid user	0.7	0.8	1.3	1.0	1.2	0.1
Mother’s age at death	0.6	0.8	1.9	0.4	0.5	1.4
Financial situation satisfaction	0.1	0.2	0.3	-0.4	0.2	-0.5
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.4	-0.6	-0.7	-0.1
Commuting to job workplace: Public transport	2.4	2.9	5.0	2.2	1.5	1.2
Eye problems/disorders: Glaucoma	0.2	0.3	0.5	-0.6	-0.7	-0.2
Medication: Blood pressure	2.9	5.4	12.7	1.6	1.1	3.6
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.5	0.2	-0.7	-0.4
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.7	0.9	1.3	0.4
High cholesterol (Self-reported)	0.2	0.3	0.5	-0.4	-0.5	0.7
Medication: Bendroflumethiazide	2.2	3.4	6.7	1.8	0.7	2.6
Medication: Paracetamol	2.4	3.7	6.9	-1.1	-1.8	-2.6
Medication: Lisinopril	0.8	1.1	1.3	0.9	1.1	1.1
Medication: Atorvastatin	0.9	1.1	2.4	-0.6	1.5	-0.7
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.4	0.5	0.9
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.3	-0.3
Ever smoked	0.4	0.7	1.8	0.3	-1.4	0.1
Basal metabolic rate	2.0	11.0	14.0	-3.7	-2.2	-3.7
Leg fat percentage (left)	3.2	11.4	19.5	-4.4	0.8	-3.8
Arm fat-free mass (left)	2.5	12.4	16.5	-4.1	-2.6	-3.8
Number of operations (self-reported)	0.9	1.4	2.5	-1.0	-0.8	-1.6
Average weekly beer plus cider intake	5.0	7.3	8.7	-2.7	-2.9	-2.4
Irritability	3.7	6.3	9.2	-2.4	-2.0	-3.0
Risk taking	0.4	0.6	1.1	0.7	1.0	0.4
Ever had prostate specific antigen (PSA) test	2.3	2.7	7.4	0.5	2.7	0.6
Fractured/broken bones in last 5 years	0.2	0.2	0.3	0.6	-0.6	0.1
Age started oral contraceptive pill	0.6	0.8	1.3	-0.8	-1.2	-0.5
Diastolic blood pressure, automated reading	0.4	1.2	2.7	0.9	-0.2	1.6
Ever depressed for a whole week	1.5	1.9	2.6	-1.1	-1.6	-1.4
Unable to work because of sickness or disability	0.3	0.3	0.8	0.4	-0.9	-0.1
Commuting to job workplace: Cycle	1.2	1.5	3.1	1.8	0.3	1.2
Myopia	0.4	0.5	1.0	1.0	0.3	0.7
Vascular/heart problems diagnosed by doctor	0.9	2.4	4.9	-0.5	-1.4	-2.2
Cholesterol lowering medication	0.4	0.6	1.1	0.6	-0.4	1.0
Medication: Omeprazole (e.g. Zanprol)	2.6	3.1	4.7	-2.0	-0.7	-2.2
Pain experienced in last month	2.2	3.6	8.4	1.2	1.0	2.9
Supplements: Calcium	3.5	3.9	4.9	-1.4	-2.2	-2.2
Basal cell carcinoma (self-reported)	0.7	0.9	1.6	0.6	-1.2	-0.8
Heart attack/myocardial infarction (self-reported)	0.1	0.2	0.6	-0.7	-0.1	0.0
Deep venous thrombosis (DVT) (self-reported)	3.6	4.6	5.7	2.4	2.2	1.9
Heart disease (siblings)	1.1	1.3	2.1	-1.2	-0.7	-1.5
Alcohol drinker status: Previous	0.6	0.7	0.9	-1.0	-0.9	-0.7
Pack years of smoking	4.3	6.3	8.6	-2.5	-2.0	-2.9
Impedance of whole body	1.0	5.1	6.2	2.5	2.4	1.8
Leg fat mass (left)	3.3	13.0	21.9	-4.7	-0.7	-4.1
Arm predicted mass (left)	2.4	12.0	15.9	-4.0	-2.4	-3.7