Hub : Genes

CAMK2G

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1108 0.0511 1.2e-03 0.004 NA 0.018 NA 0.012 1.5e-01 NA 1.4e-02 NA 3.5e-02
2 GTEx Cells Transformed fibroblasts 0.0630 0.0260 1.3e-03 0.041 NA 0.061 NA 0.048 4.7e-04 NA 2.2e-05 NA 1.6e-04
3 GTEx Esophagus Mucosa 0.0950 0.0470 4.2e-03 0.038 NA 0.046 NA 0.065 1.3e-03 NA 4.6e-04 NA 4.0e-05
4 METSIM Adipose 0.1109 0.0446 7.1e-08 0.054 0.051 0.051 0.053 0.050 1.6e-08 3.6e-08 3.4e-08 2.0e-08 4.4e-08
5 YFS Blood 0.0116 0.0070 7.6e-03 0.004 0.002 0.001 0.002 0.002 1.4e-02 5.7e-02 1.5e-01 6.7e-02 6.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.2 0.3 0.6 0.6 0.5 0.3 0.3 -0.8
Bipolar Disorder or Schizophrenia 0.3 0.7 1.4 -0.8 0.8 0.7 0.3 -1.2
Depressed Affect (Nagel 2018) 1.6 3.3 9.2 0.8 -1.7 -1.7 0.9 3.0
Depression (Nagel 2018) 0.5 0.7 1.0 0.9 -1.0 -0.4 -0.9 0.8
Intelligence (Savage-Jansen 2018) 2.2 6.9 15.5 -1.6 3.9 3.3 -1.0 -2.1
Neuroticism (Nagel 2018) 0.1 0.3 0.7 0.3 0.4 0.1 0.7 0.8
Schizophrenia (2018) 0.4 0.7 1.9 -1.4 0.6 0.7 0.2 -0.9
Schizophrenia vs Biploar Disorder 1.4 1.8 3.2 -1.8 -1.2 -1.1 1.3 1.2
Worry (Nagel 2018) 0.5 1.1 2.9 0.8 1.7 1.1 0.9 -0.3
Alzheimer’s Disease (in mother) 1.0 1.2 2.2 -1.0 1.2 1.1 -1.5 -0.4
Alzheimer’s Disease (in father) 2.7 2.9 5.0 -0.3 -2.1 -2.2 1.9 1.2
Alzheimer’s Disease (including proxy) 0.1 0.2 0.4 -0.4 0.6 -0.0 -0.5 0.3
Crohns Disease (2017) 12.7 27.8 35.2 3.9 -4.8 -5.5 5.9 5.9
Irritable Bowel Disease (IBD) 5.9 14.0 20.2 3.2 -3.0 -3.8 4.5 4.1
Ulcerative Colitis (UC) 0.5 1.0 2.4 1.6 -0.0 -0.5 1.4 0.8
Major Depression (MDD) 3.5 4.3 11.3 3.4 -1.5 -1.3 2.0 1.5
Reaction Time 0.8 1.5 6.0 -2.4 0.5 0.1 0.5 1.0
Verbal and Numeric Reasoning (VNR) 1.1 2.6 6.4 0.5 2.5 2.1 -1.1 -0.9
Breast Cancer 0.1 0.1 0.2 0.3 0.4 0.3 -0.3 0.4
Ovarian Cancer 1.4 1.8 3.2 0.1 -1.1 -1.4 1.8 1.6
Prostate Cancer 0.2 0.2 0.7 -0.1 -0.3 0.2 -0.5 -0.9
Age at First Birth 0.2 0.4 1.0 -1.0 0.5 -0.1 -0.6 -0.5
Bipolar Disorder (2011) 0.9 0.8 1.3 0.9 -0.8 -1.2 1.0 0.6
Body Mass Index (BMI) (2010) 0.3 0.4 1.0 0.5 1.0 0.9 -0.1 -0.0
Coronary Artery Disease (CAD) 7.4 8.8 13.6 2.3 -3.7 -3.6 2.2 2.6
Crohns Disease (2012) 6.0 9.7 15.5 1.8 -2.6 -3.1 3.9 3.7
Mean Putamen Volume 2.5 2.9 5.5 -2.4 1.2 1.6 -1.1 -1.9
Fasting Glucose 3.0 3.6 6.0 0.7 -2.0 -2.4 1.4 2.5
HbA1C 0.6 0.7 1.0 1.0 -0.9 -1.0 0.6 -0.6
HDL Cholesterol 2.8 4.6 5.1 -2.3 2.2 2.1 -2.0 -2.2
LDL Cholesterol 0.3 0.5 0.9 -0.2 0.6 0.5 0.9 -0.9
Lupus 0.8 1.2 4.1 0.8 0.8 0.8 2.0 -0.2
Neuroticism (2016) 0.3 0.4 1.2 1.1 -0.4 -0.4 -0.8 0.1
Primary Biliary Cirrhosis 1.9 2.8 8.5 1.5 -1.2 -0.9 2.9 0.8
Rheumatoid Arthritis 1.4 2.0 3.7 -0.0 1.9 1.9 -1.2 -1.1
Schizophrenia (2014) 0.4 0.9 3.6 -1.9 0.2 0.2 0.8 -0.6
Triglycerides 2.9 4.8 7.9 1.6 -2.4 -2.4 1.4 2.8
Type 2 Diabetes (T2D) (2012) 5.8 6.7 8.4 2.9 -1.9 -2.3 2.9 2.8
Ulcerative Colitis 0.4 0.6 1.2 1.1 0.9 0.8 0.4 -0.5
Blood Eosinophil Count 0.6 4.4 14.3 1.2 -3.8 -2.3 -0.5 0.7
Blood Platelet Count 0.7 8.1 18.0 1.5 2.2 2.7 -2.8 -4.2
Blood Red Count 0.2 1.6 4.2 1.0 -1.1 -1.0 2.0 0.6
Blood White Count 0.6 4.6 8.9 2.9 -3.0 -2.0 0.9 0.9
Heel T-Score 1.8 14.5 26.2 -1.8 5.0 5.1 -3.6 -2.4
BMI 1.1 6.1 20.9 4.6 -1.9 -1.0 0.4 2.2
Height 0.3 5.5 11.9 -1.1 -2.5 -3.5 1.9 2.2
Waist Hip Ratio (WHR) 0.6 2.6 3.8 -0.4 1.8 1.5 1.9 -1.9
Systolic Blood Pressure 1.0 4.8 13.2 0.0 -0.4 0.9 -3.6 -3.2
Smoking Status 2.5 6.0 10.4 2.6 -3.2 -3.0 1.1 1.7
Allergy or Eczema 3.5 9.3 17.6 2.1 -4.2 -3.5 1.1 3.4
Cardiovascular Disease 1.3 4.2 7.0 1.0 1.5 1.9 -2.6 -2.6
Hypothyroidism (self reported) 2.2 5.1 10.6 3.2 -1.9 -2.4 1.6 1.8
Respiratory disease 4.2 9.3 18.4 2.3 -4.3 -3.2 -0.1 3.5
Type 2 Diabetes (T2D) (2018) 1.5 2.9 5.1 2.2 -0.7 -1.1 2.1 1.8
Lung FEV1/FVC ratio 3.8 19.4 44.4 -1.6 6.7 4.5 1.1 -5.3
Lung FVC 9.3 47.3 62.1 -4.2 7.9 7.9 -6.9 -6.8
Neuroticism 0.4 1.0 2.0 0.2 -0.7 -1.1 1.1 1.4
Chronotype (morning person) 1.1 2.5 7.4 -1.8 0.9 1.0 -2.7 0.1
Hair Pigment 0.0 0.1 0.3 0.3 0.1 0.1 -0.5 0.3
Tanning 0.1 1.3 2.4 -0.5 -1.2 -1.1 1.2 1.6
Hand grip strength (left) 1.5 3.8 7.4 2.7 -1.8 -2.1 1.1 1.8
Number of treatments/medications taken 1.2 2.2 5.8 2.4 -1.2 -1.5 0.8 0.9
Average weekly spirits intake 0.6 0.7 1.9 1.0 -0.3 -0.5 0.6 1.4
Sensitivity / hurt feelings 1.8 3.0 3.6 -1.9 1.8 1.9 -1.6 -1.4
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 1.1 -0.1 -0.3 0.2 0.0
Hearing difficulty/problems: Yes 0.6 1.0 4.1 0.1 0.6 0.5 2.0 0.0
Relative age of first facial hair 0.8 1.6 3.4 -1.4 -1.0 -0.9 1.8 0.9
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.4 0.2 -1.1 -1.3 1.8 0.2
Ever used hormone-replacement therapy (HRT) 0.8 1.1 3.2 -0.7 0.6 0.6 -0.9 -1.8
Ever had hysterectomy (womb removed) 2.5 2.8 4.8 -1.1 2.0 2.2 -0.9 -1.8
Systolic blood pressure, automated reading 0.5 1.4 3.1 1.1 -1.8 -0.7 -1.0 -1.1
Eye problems/disorders: Diabetes related eye disease 2.6 2.9 4.3 0.8 -2.0 -2.0 1.3 2.1
Angina 1.7 2.3 4.2 2.0 -1.7 -1.2 1.2 1.1
Medication for hormone replacement therapy 0.6 0.7 2.2 -1.0 -0.2 -0.2 1.5 0.1
Vitamin and mineral supplements 0.6 0.9 1.6 1.3 -1.0 -0.6 -0.4 1.1
Supplements: Zinc 0.3 0.3 0.8 0.9 -0.7 -0.4 0.0 0.1
Medication: Co-codamol 4.9 5.6 9.2 2.4 -2.3 -3.0 1.5 2.4
Medication: Metformin 1.8 2.5 4.8 2.2 -0.7 -1.0 2.2 1.2
Diabetes (father) 1.8 2.3 10.4 3.2 -0.5 -0.1 -0.4 0.8
Diabetes (mother) 1.2 1.5 3.3 1.8 0.7 0.4 1.8 0.8
Severe depression (siblings) 1.4 1.6 3.7 -0.5 1.5 1.9 -0.8 -1.0
Pack years adult smoking proportion 3.3 5.0 9.1 2.8 -3.0 -2.2 1.3 1.2
Impedance of leg (right) 1.9 9.3 21.5 -3.3 4.6 3.0 0.4 -2.3
Leg fat-free mass (left) 1.3 6.8 13.4 2.9 -3.7 -2.7 0.7 2.2
Trunk fat percentage 0.3 1.2 2.5 1.5 0.1 0.6 1.6 0.8
Hand grip strength (right) 1.6 4.3 6.4 2.3 -2.5 -2.3 0.8 2.0
Townsend deprivation index at recruitment 2.3 3.3 8.0 -0.4 -2.8 -2.3 0.4 1.7
Current tobacco smoking 3.5 5.7 11.6 2.8 -3.4 -2.8 0.2 1.3
Average weekly fortified wine intake 0.3 0.3 1.6 0.2 -0.2 0.3 -1.2 0.1
Maternal smoking around birth 4.0 5.8 8.7 2.4 -3.0 -2.4 2.5 1.7
Fed-up feelings 1.1 2.1 3.5 1.2 -1.8 -1.4 -0.5 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 3.7 1.1 -1.9 -1.7 -0.1 1.2
Relative age voice broke 0.9 1.3 2.7 -1.4 -0.8 -0.5 1.6 1.2
Taking other prescription medications 4.3 6.7 8.4 2.9 -2.0 -2.9 2.9 2.1
Age when periods started (menarche) 1.6 3.8 7.3 2.7 -1.8 -1.7 1.6 1.8
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.7 1.0 0.1 0.2 -1.6 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 3.5 0.5 1.9 1.4 0.6 -0.7
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 4.5 0.1 0.9 0.8 -0.0 -2.1
Qualifications: CSEs or equivalent 0.2 0.2 0.5 0.3 0.2 0.6 -0.7 -0.4
Serious illness, injury or assault to yourself 1.4 1.6 4.8 2.2 -0.8 -1.1 1.3 -0.3
High blood pressure 0.9 2.6 5.2 0.5 1.2 1.5 -2.0 -2.3
Hayfever, allergic rhinitis or eczema 3.1 6.8 11.0 2.0 -3.3 -3.0 1.2 2.9
Multivitamins +/- minerals 0.2 0.2 0.6 -0.7 0.1 -0.1 0.2 -0.6
Stomach or abdominal pain in last month 1.4 1.8 7.3 2.7 0.3 0.6 0.1 -1.1
Supplements: Glucosamine 2.7 3.6 8.3 0.5 -1.1 -2.1 1.9 2.9
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 5.0 0.2 2.2 1.6 -1.4 -1.6
Medication: Atenolol 0.2 0.2 0.6 0.2 -0.3 -0.7 0.8 -0.0
Medication: Levothyroxine sodium 0.4 0.7 1.5 0.8 -0.5 -1.0 1.2 0.4
Sitting height 0.2 1.7 2.2 1.3 -1.2 -1.5 1.1 1.4
Chronic bronchitis/emphysema (father) 0.5 0.6 2.0 1.4 -0.4 -0.1 0.8 -0.1
High blood pressure (mother) 3.8 5.4 7.2 -0.2 2.5 2.7 -2.7 -2.6
Body mass index (BMI) 0.9 4.0 12.0 3.5 -1.9 -0.9 0.8 1.8
Impedance of leg (left) 1.9 9.4 21.2 -3.3 4.6 3.2 0.2 -2.2
Leg predicted mass (left) 1.3 6.8 13.6 2.9 -3.7 -2.6 0.7 2.2
Trunk fat mass 0.5 2.0 4.6 2.1 -1.0 -0.4 1.6 1.2
Waist circumference 0.7 2.5 6.2 2.5 -1.5 -0.7 1.4 1.2
Number of incorrect matches in round 0.6 1.0 1.6 -1.3 1.2 0.8 0.2 -1.2
Past tobacco smoking 0.2 0.4 1.4 -0.6 0.1 0.5 -1.2 -0.4
Alcohol usually taken with meals 2.1 3.4 6.0 -2.4 1.6 1.1 -1.6 -2.2
Nervous feelings 0.5 0.9 1.8 0.7 1.3 1.0 0.4 -1.0
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.2 5.6 2.4 -1.9 -2.1 0.5 1.4
Hearing difficulty/problems with background noise 0.7 1.1 4.4 -0.3 0.5 0.1 2.1 0.7
Hair/balding pattern: Pattern 2 0.7 0.9 2.2 -0.6 -1.5 -0.7 -0.2 1.1
Had menopause 0.6 0.7 1.5 0.1 -1.2 -0.9 1.1 0.1
Had other major operations 0.3 0.4 0.7 0.2 0.0 -0.9 0.8 0.8
Forced vital capacity (FVC) 3.2 12.2 18.7 -2.7 4.3 3.7 -3.4 -3.1
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 4.4 0.4 2.1 1.8 -0.1 -0.9
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 0.2 -0.6 -0.9 1.1 0.4
Qualifications: None of the above 0.5 1.0 1.7 -0.7 -1.3 -1.0 0.5 1.3
Financial difficulties in last 2 years 0.4 0.5 1.0 0.7 -0.5 -0.7 -0.5 1.0
Mouth/teeth dental problems 0.6 1.0 3.5 -1.0 -0.5 0.5 -1.9 0.1
Heart attack 0.5 0.7 1.7 1.3 -0.9 -0.5 -0.8 0.3
Allergy 5.6 12.9 20.6 -2.8 4.5 4.1 -1.3 -4.2
Pain all over the body in last month 1.0 1.1 2.1 1.5 -0.5 -0.9 1.4 0.6
Diabetes (self-reported) 1.4 2.1 3.7 1.4 -1.1 -1.3 1.9 1.4
Hayfever/allergic rhinitis (self-reported) 2.2 2.9 4.1 2.0 -2.0 -2.0 -0.9 1.4
Medication: Ramipril 1.0 1.3 3.4 1.8 -0.8 -0.9 -0.5 1.1
Medication: Simvastatin 0.3 0.4 0.8 0.9 -0.5 -0.7 -0.7 0.3
Fluid intelligence score 1.6 3.3 6.2 1.7 2.5 2.2 -0.9 -1.4
Illnesses of siblings 1.3 1.8 4.8 -1.2 0.8 1.2 -2.2 -0.8
Neuroticism score 0.1 0.1 0.3 0.3 0.5 0.1 0.6 0.3
Weight 0.9 4.3 8.3 2.9 -2.4 -1.6 1.3 1.8
Impedance of arm (right) 1.3 6.3 10.9 -2.7 3.3 2.5 1.1 -2.3
Arm fat percentage (right) 0.4 1.7 6.2 2.5 -0.3 0.5 1.3 0.5
Trunk fat-free mass 0.8 4.8 9.9 2.3 -3.1 -2.5 0.2 1.4
Hip circumference 0.9 3.8 7.3 2.7 -2.1 -1.3 1.1 2.1
Time employed in main current job 0.5 0.5 1.7 -1.3 0.0 0.1 -0.2 -1.0
Alcohol intake versus 10 years previously 1.1 1.6 2.6 -0.2 -1.5 -1.6 1.6 0.7
Father’s age at death 1.3 1.8 5.2 -0.7 1.3 1.2 0.1 -2.3
Worrier / anxious feelings 0.7 1.3 3.2 0.2 1.8 1.1 0.4 -1.4
Frequency of tiredness / lethargy in last 2 weeks 6.4 10.4 16.4 2.7 -3.6 -3.3 2.1 4.1
Falls in the last year 0.3 0.3 0.6 0.0 0.8 0.8 0.1 -0.7
Hair/balding pattern: Pattern 3 0.4 0.6 1.5 -0.3 1.2 0.5 -0.5 -1.0
Number of live births 0.5 0.7 2.0 -0.1 1.4 0.7 -1.1 0.1
Forced expiratory volume in 1-second (FEV1) 6.6 22.2 41.1 -3.0 6.4 5.5 -3.3 -4.5
Pulse rate 2.4 4.0 9.7 2.6 -0.8 -1.2 3.1 1.3
Happiness 0.3 0.3 0.9 0.1 -0.7 -0.3 1.0 -0.1
Noisy workplace 1.7 2.1 3.5 0.6 -1.9 -1.0 1.7 1.7
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.8 0.2 1.5 0.9 -1.5 -2.8
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.7 1.7 -0.4 -0.3 -0.4 0.4
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 0.6 -0.9 -1.3 0.2 0.5
Asthma 5.6 11.1 17.4 2.8 -4.2 -3.6 0.9 4.0
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.8 5.2 0.0 -2.3 -1.5 1.1 0.8
Medication: Cholesterol lowering 0.7 1.0 3.1 1.7 1.0 0.9 -0.2 -0.5
Depression (self-reported) 0.3 0.3 1.5 1.2 -0.1 -0.1 0.2 -0.3
Medication: Lansoprazole 0.2 0.3 0.9 1.0 -0.2 -0.3 -0.3 -0.5
Prospective memory result 0.3 0.4 1.2 0.0 -0.7 -0.5 -0.2 1.1
Lung cancer (father) 0.1 0.1 0.5 -0.0 -0.0 0.0 0.4 0.7
Illnesses of mother 4.1 5.1 9.5 -0.3 -3.1 -3.0 1.7 2.0
Forced expiratory volume in 1-second (FEV1), Best measure 6.3 20.2 34.7 -2.7 5.9 5.2 -3.3 -4.6
Pulse wave Arterial Stiffness index 0.5 0.6 2.4 0.5 -0.1 0.0 1.6 0.6
Impedance of arm (left) 1.6 7.6 11.7 -3.4 3.4 2.7 1.2 -2.4
Arm fat mass (right) 0.9 3.5 9.2 3.0 -1.7 -0.9 1.6 1.5
Trunk predicted mass 0.9 5.0 10.5 2.3 -3.2 -2.6 0.3 1.4
Standing height 0.1 1.5 3.2 -1.1 -1.4 -1.8 1.0 0.4
Length of working week for main job 0.9 1.0 3.0 -0.7 0.7 0.8 -1.7 -0.5
Exposure to tobacco smoke at home 4.5 5.0 6.8 1.1 -2.6 -2.6 2.1 2.4
Breastfed as a baby 2.2 2.7 4.6 -2.1 1.7 1.1 -1.4 -1.6
Tense / ‘highly strung’ 0.2 0.3 0.7 0.4 0.5 -0.4 0.8 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.6 2.4 4.2 -0.2 1.9 1.7 -1.1 -2.1
Hair/balding pattern: Pattern 4 0.4 0.9 3.0 1.7 -0.2 -0.1 -0.1 1.1
Birth weight of first child 0.1 0.1 0.2 -0.2 0.5 0.0 0.4 -0.4
Peak expiratory flow (PEF) 2.2 5.2 13.3 -1.5 3.6 2.9 -0.7 -1.2
Pulse wave reflection index 0.4 0.5 0.9 -0.9 0.9 0.6 -0.7 -0.2
Ever highly irritable/argumentative for 2 days 5.5 6.6 10.0 2.4 -2.7 -2.4 2.0 3.2
Loud music exposure frequency 0.3 0.3 0.7 -0.8 -0.5 -0.4 0.7 -0.0
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 3.5 1.9 -0.4 -0.4 -0.5 0.1
Mouth/teeth dental problems: Bleeding gums 1.8 2.3 8.1 1.3 0.5 -0.7 2.8 1.1
Blood clot in the leg (DVT) 1.5 1.9 5.0 -0.5 1.5 1.3 -2.2 -0.5
Medication: Paracetamol 1.4 2.3 7.6 0.2 -0.9 -1.1 2.8 1.3
Headache pain in last month 0.2 0.4 1.2 -0.8 0.1 -0.2 1.1 0.2
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.7 -1.3 -0.8 -0.8 0.1 1.3
Glaucoma (self-reported) 0.9 1.1 2.8 1.7 -0.9 -1.2 -0.2 0.7
Gout (self-reported) 0.7 1.0 4.7 0.0 -0.4 0.1 -2.2 -0.4
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 4.5 1.8 -1.6 -2.1 1.9 1.5
Medication: Amlodipine 0.7 1.0 2.2 0.5 0.5 1.5 -0.8 -1.3
Medication: Ventolin 100micrograms inhaler 3.3 4.2 8.1 1.1 -2.3 -2.5 0.7 2.8
Birth weight 2.1 4.5 6.9 -1.7 2.5 2.2 -1.4 -2.6
Chronic bronchitis/emphysema (mother) 1.0 1.1 3.7 -0.6 -0.4 -0.6 1.9 -1.0
High blood pressure (siblings) 0.7 1.0 2.7 1.6 -1.0 -1.0 0.5 0.1
Forced vital capacity (FVC), Best measure 3.2 11.7 16.0 -2.6 4.0 3.7 -3.7 -3.0
Body fat percentage 0.4 1.5 4.2 2.0 0.2 0.7 1.5 0.9
Leg fat percentage (right) 0.5 1.7 5.2 2.3 1.0 1.0 1.0 0.6
Arm fat-free mass (right) 1.1 5.7 11.3 2.3 -3.4 -2.5 0.4 2.3
Exposure to tobacco smoke outside home 7.4 9.8 16.4 1.8 -2.8 -3.0 4.1 3.5
Comparative body size at age 10 4.5 12.4 18.9 -1.6 3.8 4.3 -3.4 -3.8
Number of full brothers 1.9 2.3 3.4 -0.4 -1.9 -1.7 1.8 1.4
Worry too long after embarrassment 0.4 0.7 2.3 0.1 1.5 0.9 -0.1 -0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.0 0.7 0.1 0.2 -1.0 -0.6
Wheeze or whistling in the chest in last year 5.3 9.4 19.8 4.5 -3.5 -2.8 0.9 2.6
Number of children fathered 0.5 0.5 1.2 1.1 0.7 0.6 -0.9 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.2 0.3 0.8 -0.9 0.3 -0.2 -0.1 -0.7
Age at first live birth 0.8 1.4 2.8 -1.0 1.2 0.8 -1.0 -1.7
Pulse wave peak to peak time 0.4 0.5 2.2 -0.3 0.0 -0.1 -1.5 -0.6
Health satisfaction 5.3 6.9 10.3 3.2 -2.9 -2.5 1.6 2.7
Shortness of breath walking on level ground 6.4 7.6 12.6 3.5 -3.5 -2.5 0.4 2.5
Qualifications: College or University degree 1.1 3.4 5.8 1.3 1.8 1.8 -1.7 -2.4
Eye problems/disorders: None of the above 1.6 1.9 5.6 -2.4 1.0 1.3 -0.8 -0.7
Mouth/teeth dental problems: Loose teeth 1.5 1.7 3.4 1.1 -1.1 -1.8 1.0 1.4
Emphysema/chronic bronchitis 1.0 1.2 2.1 1.1 -1.4 -1.5 -0.3 0.6
Medication for pain relief, constipation, heartburn 1.2 2.0 6.0 -0.7 1.1 1.2 -2.5 -0.9
Neck or shoulder pain in last month 4.8 6.9 12.3 1.5 -2.7 -2.7 3.5 2.3
Medication: Blood pressure 0.5 0.9 3.6 1.9 -0.1 -0.1 -0.2 -1.0
Angina (self-reported) 2.5 3.3 5.5 2.3 -2.1 -1.7 1.5 1.3
Migraine (self-reported) 0.2 0.3 0.6 -0.7 -0.4 -0.4 -0.8 -0.3
Medication: Ibuprofen 1.6 1.9 5.2 0.3 -2.3 -1.6 0.9 0.9
Medication: Allopurinol 1.1 1.5 5.5 0.3 0.6 0.9 -2.3 -0.8
Medication: Omeprazole 1.5 1.8 5.4 1.3 0.1 -0.6 2.3 1.3
Medication: Seretide 50 evohaler 0.2 0.2 0.3 0.6 -0.2 -0.3 -0.4 0.6
Mean time to correctly identify matches 0.8 1.5 6.6 -2.6 0.7 0.2 0.5 0.6
Heart disease (mother) 0.6 0.7 1.3 1.0 1.0 0.7 -1.1 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.9 4.7 7.7 2.0 -2.1 -2.5 1.0 2.8
Whole body fat mass 0.6 2.5 6.3 2.5 -1.1 -0.5 1.6 1.5
Leg fat mass (right) 0.7 2.7 8.1 2.8 -0.9 -0.5 1.3 1.7
Arm predicted mass (right) 1.3 6.4 12.8 2.4 -3.6 -2.8 0.5 2.3
Pulse rate, automated reading 3.2 10.4 26.9 5.2 -1.6 -2.2 3.4 2.4
Alcohol intake frequency. 0.4 0.8 2.8 0.7 -0.7 -0.6 0.2 1.7
Comparative height size at age 10 0.1 0.5 0.8 -0.7 0.2 -0.8 0.9 -0.8
Number of full sisters 3.9 4.8 9.7 -0.3 -2.0 -2.6 1.8 3.1
Suffer from ‘nerves’ 0.4 0.7 1.3 -0.1 1.0 1.1 -0.7 -0.9
Overall health rating 4.5 9.7 15.5 3.9 -3.5 -3.0 2.9 1.9
Chest pain or discomfort 3.0 4.3 8.1 2.9 -2.4 -2.1 0.3 1.9
Had major operations 0.3 0.4 1.2 -0.3 0.1 0.2 -0.8 -1.1
Age at last live birth 0.5 0.7 1.6 -0.4 0.8 0.5 -1.0 -1.3
Family relationship satisfaction 0.1 0.1 0.3 -0.6 -0.2 0.3 0.4 -0.2
Leg pain on walking 5.5 6.8 10.1 2.6 -3.2 -2.5 2.0 2.7
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.3 1.1 -1.0 0.1 -0.0 0.5 -0.3
Commuting to job workplace: Car/motor vehicle 0.6 0.6 2.3 -0.0 0.8 -0.2 0.4 1.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.1 -1.3 0.8 1.0 -0.1 -1.4
Medication: Aspirin 0.4 0.5 2.2 1.5 0.2 0.2 0.2 -0.4
Supplements: Vitamin C 1.2 1.4 2.8 -0.7 1.6 1.7 -0.1 -1.1
Knee pain experienced in last month 1.5 2.4 6.2 0.2 -1.5 -1.6 2.5 0.9
Hypertension (Self-reported) 0.6 1.7 3.5 0.6 0.8 1.1 -1.9 -1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 0.9 -0.9 -0.8 -0.9 0.7 -0.2
Illnesses of father: Heart disease 0.7 1.0 1.9 1.4 -1.2 -0.7 0.8 0.8
Illnesses of siblings: Diabetes 2.5 3.1 10.3 0.5 -1.0 -1.6 3.2 1.1
Smoking status: Previous 0.4 0.6 1.3 -0.4 1.1 0.7 1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 1.9 0.3 -1.4 -1.2 0.0 1.2
Whole body fat-free mass 1.1 6.5 13.1 2.7 -3.6 -2.8 0.5 2.0
Leg fat-free mass (right) 1.4 7.3 15.3 2.8 -3.9 -2.7 0.6 2.3
Arm fat percentage (left) 0.4 1.6 5.4 2.3 -0.4 0.5 1.3 0.6
Average weekly red wine intake 0.3 0.5 1.7 1.3 0.4 0.2 0.8 0.3
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.7 1.1 0.8 0.3 0.9 -1.3
Mood swings 1.0 1.8 3.5 0.5 -0.6 -1.4 1.9 1.7
Loneliness, isolation 1.1 1.6 2.9 -0.5 0.9 1.0 -1.7 -1.7
Long-standing illness, disability or infirmity 3.0 4.6 5.7 2.4 -2.0 -2.1 1.9 2.3
Ever had bowel cancer screening 3.1 3.7 4.9 -2.1 2.0 1.3 -2.2 -1.8
Diabetes diagnosed by doctor 2.3 3.7 6.0 2.0 -1.5 -1.8 2.5 1.7
Ever had stillbirth, spontaneous miscarriage or termination 0.0 0.0 0.0 0.1 -0.1 0.0 0.2 0.2
Friendships satisfaction 0.3 0.3 0.6 -0.4 0.3 0.6 0.8 -0.6
Qualifications: nursing, teaching 0.8 1.3 2.3 -0.1 1.4 0.6 -1.3 -1.5
Commuting to job workplace: Walk 0.2 0.2 0.9 0.2 -0.5 -0.2 1.0 -0.0
Eye problems/disorders: Cataract 1.5 1.7 3.5 1.9 -1.6 -1.4 0.5 0.6
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 6.2 -1.1 1.7 1.8 -0.4 -2.5
Medication for cholesterol 0.4 0.6 1.0 -0.4 1.0 0.9 0.9 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.4 2.9 5.5 0.1 2.3 2.1 -1.8 -0.9
Back pain experienced in last month 4.1 6.0 9.6 1.0 -2.7 -2.7 3.1 2.3
Mineral and other dietary supplements 0.4 0.5 1.2 0.3 -0.3 0.3 -1.1 -1.0
Breast cancer (self-reported) 0.6 0.7 1.4 -0.5 0.7 0.7 1.0 -1.2
Asthma (self-reported) 5.2 10.4 16.7 2.8 -4.1 -3.4 0.5 3.9
Osteoporosis (self-reported) 1.8 2.2 8.6 -2.9 0.8 0.1 0.8 -1.2
Osteoarthritis (self-reported) 2.8 3.7 11.4 3.4 -0.9 -1.9 1.0 1.2
Medication: Aspirin 0.6 0.8 3.7 1.9 0.3 0.2 0.5 -0.2
Medication: Gliclazide 0.6 0.7 1.4 1.1 -0.7 -0.4 -0.3 1.2
Illnesses of father: None of the above (group 1) 0.5 0.7 1.4 -1.2 1.0 0.4 0.8 0.5
Smoking status: Current 4.7 7.4 14.9 3.1 -3.9 -3.2 0.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 7.6 16.1 26.1 -2.4 5.1 4.6 -3.3 -4.1
Whole body water mass 1.2 6.7 13.7 2.7 -3.7 -2.9 0.4 2.0
Leg predicted mass (right) 1.4 7.3 15.5 2.8 -3.9 -2.7 0.6 2.3
Arm fat mass (left) 0.9 3.7 8.9 3.0 -1.8 -1.0 1.7 1.6
Number of self-reported non-cancer illnesses 1.8 3.1 5.2 2.3 -1.9 -2.3 1.1 0.9
Average weekly champagne plus white wine intake 0.5 0.7 2.7 -1.6 0.3 0.3 -0.6 -0.5
Miserableness 1.0 1.7 4.9 0.6 -1.4 -1.1 0.2 2.2
Guilty feelings 0.2 0.4 0.5 0.6 0.7 0.5 -0.5 -0.6
Wears glasses or contact lenses 0.5 0.6 1.8 0.5 -0.6 -0.8 1.3 -0.3
Ever taken oral contraceptive pill 0.8 0.8 2.3 1.5 -0.0 -0.4 1.1 0.7
Hearing aid user 0.4 0.5 0.8 0.4 0.5 0.9 -0.6 -0.9
Mother’s age at death 0.7 0.9 1.8 -1.1 0.7 0.8 -1.3 -0.7
Financial situation satisfaction 0.2 0.3 1.0 1.0 -0.5 0.2 -0.3 -0.0
Tinnitus: Yes, now most or all of the time 0.7 0.8 3.3 -0.2 -0.5 -0.5 0.2 1.8
Commuting to job workplace: Public transport 1.1 1.3 3.8 -0.8 0.2 1.2 -0.7 -1.9
Eye problems/disorders: Glaucoma 0.9 1.1 2.4 1.6 -0.7 -1.0 1.0 0.8
Medication: Blood pressure 1.4 2.7 9.6 -0.1 0.8 1.0 -3.1 -1.4
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.4 0.6 -1.1 -0.9 1.2 -0.0
Supplements: Fish oil (including cod liver oil) 2.0 2.6 5.1 -1.8 2.2 1.8 -0.5 -1.1
High cholesterol (Self-reported) 0.1 0.1 0.4 0.3 -0.0 -0.3 -0.7 -0.1
Medication: Bendroflumethiazide 0.9 1.4 4.2 -0.3 0.5 0.4 -2.1 -1.5
Medication: Paracetamol 2.2 3.3 8.4 0.4 -1.3 -1.6 2.9 2.0
Medication: Lisinopril 0.8 1.0 2.8 -0.1 0.7 0.6 -1.7 -1.2
Medication: Atorvastatin 0.9 1.1 2.6 -0.7 1.2 1.6 0.4 -0.8
Illnesses of father: High blood pressure 0.8 1.0 2.7 0.2 0.1 0.4 -1.6 -1.5
Alcohol drinker status: Never 0.4 0.5 2.2 0.0 0.2 -0.2 0.2 1.5
Ever smoked 0.6 1.0 2.1 1.4 -0.7 -1.2 1.0 0.4
Basal metabolic rate 1.0 5.8 10.6 2.8 -3.3 -2.5 0.7 2.0
Leg fat percentage (left) 0.5 1.7 5.4 2.3 0.6 0.9 0.9 0.9
Arm fat-free mass (left) 1.4 6.9 11.6 3.1 -3.4 -2.8 0.5 2.3
Number of operations (self-reported) 0.7 1.0 4.0 2.0 -0.3 -0.9 0.5 0.2
Average weekly beer plus cider intake 4.3 6.2 7.9 1.9 -2.8 -2.6 2.2 2.8
Irritability 3.4 5.7 12.4 1.1 -2.1 -2.5 3.5 2.0
Risk taking 0.2 0.3 0.7 -0.0 0.5 0.5 -0.8 0.5
Ever had prostate specific antigen (PSA) test 4.7 5.4 10.2 -1.5 2.3 2.4 -1.8 -3.2
Fractured/broken bones in last 5 years 0.1 0.2 0.7 0.3 -0.2 -0.2 -0.2 -0.8
Age started oral contraceptive pill 0.3 0.4 0.9 0.1 -0.3 -0.8 1.0 0.4
Diastolic blood pressure, automated reading 0.3 0.9 2.5 1.6 -1.3 -0.3 0.4 0.0
Ever depressed for a whole week 0.4 0.5 1.1 0.0 -0.5 -1.0 0.1 1.0
Unable to work because of sickness or disability 0.4 0.6 1.0 -0.7 -0.7 -0.9 1.0 0.1
Commuting to job workplace: Cycle 1.1 1.3 2.8 -1.7 -0.3 0.5 -0.9 -1.6
Myopia 0.7 1.0 2.8 -1.0 0.9 0.2 -1.7 0.7
Vascular/heart problems diagnosed by doctor 0.7 1.8 3.0 -1.4 -0.5 -0.9 1.7 1.7
Cholesterol lowering medication 0.3 0.4 1.3 -0.3 -0.6 -0.5 -1.1 -0.2
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 5.9 1.4 0.2 -0.5 2.4 0.6
Pain experienced in last month 1.1 1.9 7.0 -0.4 0.8 1.1 -2.6 -0.6
Supplements: Calcium 2.4 2.6 4.5 1.4 -1.7 -2.1 0.8 1.7
Basal cell carcinoma (self-reported) 0.4 0.4 0.7 -0.8 -0.4 -0.8 -0.6 0.6
Heart attack/myocardial infarction (self-reported) 0.6 0.8 1.6 1.3 -1.3 -0.7 -0.5 0.3
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 6.5 -0.5 1.5 1.4 -2.5 -0.3
Heart disease (siblings) 1.4 1.7 3.2 0.6 -1.1 -1.2 1.6 1.8
Alcohol drinker status: Previous 0.5 0.5 0.9 0.8 -1.0 -0.9 -0.1 0.4
Pack years of smoking 3.3 4.8 9.5 2.2 -3.1 -2.4 1.5 1.2
Impedance of whole body 1.9 9.6 18.4 -3.7 4.3 3.2 0.7 -2.4
Leg fat mass (left) 0.8 3.0 8.4 2.9 -1.1 -0.6 1.4 1.8
Arm predicted mass (left) 1.2 6.2 10.7 3.0 -3.3 -2.6 0.5 2.1