Hub : Genes

MYOZ1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Brain Cerebellum 0.8230 0.0600 8.9e-08 0.066 NA 0.040 NA -0.003 5.3e-03 NA 2.4e-02 NA 4.0e-01
2 GTEx Heart Atrial Appendage 0.4320 0.0730 0.0e+00 0.250 NA 0.359 NA 0.378 1.4e-11 NA 5.2e-17 NA 5.4e-18
3 ROSMAP Brain Pre-frontal Cortex 0.0411 0.0195 6.5e-04 0.005 0.017 0.011 0.015 0.006 6.1e-02 0.0026 1.3e-02 0.0045 5.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 1.5 0.0 -1.2 0.5
Bipolar Disorder or Schizophrenia 0.0 0.1 0.1 0.0 -0.2 0.4
Depressed Affect (Nagel 2018) 0.2 0.5 1.3 0.0 0.5 -1.1
Depression (Nagel 2018) 0.2 0.2 0.5 0.0 0.7 -0.5
Intelligence (Savage-Jansen 2018) 0.8 2.6 4.9 0.0 -1.7 2.2
Neuroticism (Nagel 2018) 0.0 0.1 0.3 0.0 -0.1 -0.6
Schizophrenia (2018) 0.1 0.2 0.6 0.0 0.7 0.1
Schizophrenia vs Biploar Disorder 0.5 0.6 1.5 0.0 1.2 -0.6
Worry (Nagel 2018) 0.3 0.6 1.7 0.0 -1.3 0.2
Alzheimer’s Disease (in mother) 0.2 0.2 0.3 0.0 0.5 0.6
Alzheimer’s Disease (in father) 0.2 0.2 0.7 0.0 0.0 -0.8
Alzheimer’s Disease (including proxy) 0.1 0.1 0.2 0.0 -0.2 0.5
Crohns Disease (2017) 1.5 3.3 8.5 0.0 -2.9 -1.2
Irritable Bowel Disease (IBD) 0.8 1.8 5.1 0.0 -2.3 -0.6
Ulcerative Colitis (UC) 0.1 0.3 0.7 0.0 -0.8 0.3
Major Depression (MDD) 0.5 0.6 1.3 0.0 -1.2 -0.7
Reaction Time 0.8 1.6 4.2 0.0 -0.7 2.1
Verbal and Numeric Reasoning (VNR) 0.2 0.6 1.1 0.0 -1.0 0.8
Breast Cancer 2.8 6.6 10.6 0.0 3.1 -3.3
Ovarian Cancer 0.2 0.3 0.9 0.0 0.2 -0.9
Prostate Cancer 0.1 0.2 0.5 0.0 0.3 -0.7
Age at First Birth 0.0 0.1 0.1 0.0 0.3 -0.3
Bipolar Disorder (2011) 0.2 0.2 0.7 0.0 -0.2 -0.8
Body Mass Index (BMI) (2010) 1.0 1.3 2.7 0.0 -1.6 1.1
Coronary Artery Disease (CAD) 1.3 1.6 4.0 0.0 0.9 -2.0
Crohns Disease (2012) 1.6 2.6 7.7 0.0 -2.8 0.4
Mean Putamen Volume 1.5 1.7 4.5 0.0 2.1 -0.8
Fasting Glucose 0.1 0.2 0.5 0.0 -0.0 -0.7
HbA1C 0.0 0.0 0.1 0.0 0.2 -0.0
HDL Cholesterol 0.5 0.9 2.7 0.0 -0.0 1.6
LDL Cholesterol 0.9 1.4 2.6 0.0 -1.2 1.6
Lupus 1.6 2.4 4.3 0.0 -2.1 1.7
Neuroticism (2016) 0.3 0.4 0.8 0.0 0.7 -0.9
Primary Biliary Cirrhosis 3.5 5.0 11.8 0.0 -3.4 1.8
Rheumatoid Arthritis 0.1 0.1 0.3 0.0 -0.3 0.5
Schizophrenia (2014) 0.0 0.1 0.1 0.0 0.4 0.2
Triglycerides 0.5 0.9 2.6 0.0 0.3 -1.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 1.3 0.0 -1.2 -1.2
Ulcerative Colitis 0.2 0.3 0.5 0.0 -0.7 0.7
Blood Eosinophil Count 2.2 16.6 29.4 0.0 4.5 -5.4
Blood Platelet Count 0.2 2.2 3.6 0.0 1.7 -1.9
Blood Red Count 0.0 0.3 0.7 0.0 0.5 -0.8
Blood White Count 0.2 1.4 4.1 0.0 -0.1 -2.0
Heel T-Score 0.2 1.2 2.6 0.0 1.0 1.6
BMI 0.3 1.8 5.3 0.0 -2.3 0.1
Height 0.3 5.0 11.9 0.0 -3.5 1.7
Waist Hip Ratio (WHR) 1.0 4.6 7.5 0.0 -2.5 2.7
Systolic Blood Pressure 10.0 49.9 91.8 0.0 9.6 -7.6
Smoking Status 1.0 2.5 6.2 0.0 1.1 -2.5
Allergy or Eczema 3.1 8.2 18.1 0.0 2.5 -4.3
Cardiovascular Disease 1.7 5.7 9.6 0.0 3.1 -2.7
Hypothyroidism (self reported) 0.6 1.3 4.0 0.0 -0.1 -2.0
Respiratory disease 4.1 9.2 17.8 0.0 3.1 -4.2
Type 2 Diabetes (T2D) (2018) 0.8 1.4 4.2 0.0 -2.0 0.3
Lung FEV1/FVC ratio 2.5 12.7 21.8 0.0 -4.0 4.7
Lung FVC 1.7 8.8 25.7 0.0 -0.8 5.1
Neuroticism 0.0 0.1 0.2 0.0 -0.0 -0.4
Chronotype (morning person) 0.1 0.2 0.6 0.0 0.7 0.3
Hair Pigment 0.0 0.3 0.6 0.0 0.8 -0.4
Tanning 0.1 0.6 1.6 0.0 0.5 -1.3
Hand grip strength (left) 0.7 2.0 5.3 0.0 -0.7 -2.3
Number of treatments/medications taken 0.3 0.5 1.3 0.0 -1.1 -0.4
Average weekly spirits intake 0.1 0.1 0.3 0.0 -0.6 -0.1
Sensitivity / hurt feelings 0.6 1.0 2.9 0.0 0.0 1.7
Frequency of depressed mood in last 2 weeks 0.8 1.1 2.1 0.0 -1.4 1.1
Hearing difficulty/problems: Yes 7.7 11.8 21.8 0.0 -3.7 4.7
Relative age of first facial hair 0.0 0.1 0.1 0.0 0.3 -0.4
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.5 0.0 -0.7 -0.5
Ever used hormone-replacement therapy (HRT) 0.0 0.1 0.1 0.0 0.2 0.4
Ever had hysterectomy (womb removed) 0.5 0.5 1.6 0.0 -0.1 1.3
Systolic blood pressure, automated reading 9.9 28.7 45.4 0.0 6.7 -6.4
Eye problems/disorders: Diabetes related eye disease 0.1 0.2 0.4 0.0 -0.7 -0.2
Angina 0.3 0.4 1.0 0.0 -0.3 -1.0
Medication for hormone replacement therapy 0.1 0.1 0.1 0.0 0.4 -0.4
Vitamin and mineral supplements 1.5 2.0 3.0 0.0 1.7 -1.7
Supplements: Zinc 0.1 0.1 0.3 0.0 -0.6 -0.1
Medication: Co-codamol 0.8 0.9 2.3 0.0 -0.6 -1.5
Medication: Metformin 2.8 4.0 10.4 0.0 -3.2 1.3
Diabetes (father) 0.6 0.8 2.0 0.0 0.7 -1.4
Diabetes (mother) 1.5 1.9 4.6 0.0 -2.1 1.1
Severe depression (siblings) 0.6 0.6 1.6 0.0 -0.6 1.3
Pack years adult smoking proportion 0.3 0.5 1.3 0.0 -0.6 -1.1
Impedance of leg (right) 0.4 2.0 5.0 0.0 -1.0 2.2
Leg fat-free mass (left) 0.2 0.9 2.6 0.0 -1.6 -0.1
Trunk fat percentage 1.4 5.7 11.2 0.0 -3.3 2.4
Hand grip strength (right) 0.4 1.2 3.5 0.0 -0.4 -1.9
Townsend deprivation index at recruitment 1.1 1.6 2.4 0.0 1.5 -1.5
Current tobacco smoking 1.8 3.0 7.0 0.0 1.4 -2.6
Average weekly fortified wine intake 4.3 5.0 9.3 0.0 2.4 -3.1
Maternal smoking around birth 2.9 4.2 9.1 0.0 1.9 -3.0
Fed-up feelings 1.2 2.2 3.6 0.0 1.7 -1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 1.6 0.0 1.0 -1.3
Relative age voice broke 0.7 1.1 2.6 0.0 1.6 -0.8
Taking other prescription medications 0.9 1.4 2.9 0.0 -1.2 -1.7
Age when periods started (menarche) 0.3 0.8 2.2 0.0 0.4 -1.5
Bilateral oophorectomy (both ovaries removed) 0.0 0.0 0.0 0.0 0.1 0.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 0.0 -0.7 0.6
Tinnitus: Yes, but not now, but have in the past 0.1 0.1 0.3 0.0 0.5 0.3
Qualifications: CSEs or equivalent 1.1 1.4 2.7 0.0 1.6 -1.2
Serious illness, injury or assault to yourself 0.5 0.7 1.9 0.0 -1.4 0.2
High blood pressure 0.9 2.5 4.1 0.0 2.0 -1.9
Hayfever, allergic rhinitis or eczema 2.1 4.7 10.8 0.0 1.8 -3.3
Multivitamins +/- minerals 0.1 0.2 0.5 0.0 -0.7 0.1
Stomach or abdominal pain in last month 0.3 0.4 1.1 0.0 -1.0 -0.1
Supplements: Glucosamine 0.7 0.9 2.2 0.0 -1.5 0.7
Diverticular disease/diverticulitis (self-reported) 1.9 2.2 3.7 0.0 -1.9 1.7
Medication: Atenolol 0.0 0.0 0.0 0.0 -0.1 -0.2
Medication: Levothyroxine sodium 0.2 0.4 1.1 0.0 -1.1 -0.2
Sitting height 0.6 4.4 10.9 0.0 -3.3 1.5
Chronic bronchitis/emphysema (father) 1.2 1.4 2.8 0.0 1.2 -1.7
High blood pressure (mother) 1.4 2.0 4.6 0.0 2.1 -1.2
Body mass index (BMI) 0.5 2.2 6.3 0.0 -2.5 0.5
Impedance of leg (left) 0.3 1.7 4.4 0.0 -0.8 2.1
Leg predicted mass (left) 0.1 0.8 2.3 0.0 -1.5 -0.2
Trunk fat mass 1.4 5.9 13.3 0.0 -3.6 2.1
Waist circumference 1.5 5.5 12.5 0.0 -3.5 2.0
Number of incorrect matches in round 1.7 2.8 6.6 0.0 -1.4 2.6
Past tobacco smoking 0.0 0.0 0.1 0.0 -0.1 0.3
Alcohol usually taken with meals 0.3 0.5 1.4 0.0 -0.0 1.2
Nervous feelings 0.1 0.1 0.3 0.0 -0.5 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.8 2.3 0.0 -1.5 -0.1
Hearing difficulty/problems with background noise 1.0 1.6 4.4 0.0 -0.7 2.1
Hair/balding pattern: Pattern 2 5.0 6.3 12.1 0.0 3.5 -2.6
Had menopause 0.3 0.4 0.6 0.0 0.8 -0.7
Had other major operations 0.2 0.2 0.6 0.0 -0.8 0.1
Forced vital capacity (FVC) 2.0 7.7 18.7 0.0 -2.0 4.3
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.6 0.0 -0.5 0.8
Ever unenthusiastic/disinterested for a whole week 0.0 0.0 0.1 0.0 -0.2 -0.3
Qualifications: None of the above 0.3 0.5 1.4 0.0 1.2 -0.4
Financial difficulties in last 2 years 0.1 0.1 0.2 0.0 0.2 -0.5
Mouth/teeth dental problems 2.8 4.3 8.8 0.0 3.0 -2.0
Heart attack 1.3 1.7 3.6 0.0 1.2 -1.9
Allergy 3.1 7.1 17.1 0.0 -2.0 4.1
Pain all over the body in last month 1.1 1.1 2.9 0.0 -1.7 0.7
Diabetes (self-reported) 0.6 0.9 2.5 0.0 -1.6 0.5
Hayfever/allergic rhinitis (self-reported) 1.8 2.4 5.8 0.0 1.1 -2.4
Medication: Ramipril 0.2 0.3 0.9 0.0 -0.1 -0.9
Medication: Simvastatin 0.1 0.1 0.2 0.0 -0.1 -0.5
Fluid intelligence score 0.2 0.3 1.0 0.0 -1.0 0.1
Illnesses of siblings 0.1 0.2 0.3 0.0 0.4 0.6
Neuroticism score 0.0 0.1 0.2 0.0 -0.5 0.2
Weight 0.9 4.3 11.5 0.0 -3.4 1.2
Impedance of arm (right) 0.7 3.1 8.9 0.0 -0.7 3.0
Arm fat percentage (right) 1.2 4.8 10.0 0.0 -3.2 2.1
Trunk fat-free mass 0.2 1.2 3.5 0.0 -1.9 -0.2
Hip circumference 1.0 4.2 10.9 0.0 -3.3 1.3
Time employed in main current job 0.0 0.0 0.0 0.0 0.1 -0.0
Alcohol intake versus 10 years previously 0.3 0.5 1.1 0.0 1.1 -0.6
Father’s age at death 0.0 0.1 0.1 0.0 0.4 -0.1
Worrier / anxious feelings 1.8 3.3 6.9 0.0 -2.6 1.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 0.0 -0.5 -0.6
Falls in the last year 1.5 2.0 4.1 0.0 -1.4 2.0
Hair/balding pattern: Pattern 3 0.8 1.2 2.2 0.0 -1.2 1.5
Number of live births 0.6 0.8 1.4 0.0 -1.0 1.2
Forced expiratory volume in 1-second (FEV1) 4.7 15.7 36.4 0.0 -3.3 6.0
Pulse rate 5.1 8.6 18.7 0.0 -4.3 2.7
Happiness 1.0 1.3 2.2 0.0 -1.3 1.5
Noisy workplace 0.1 0.1 0.3 0.0 0.4 -0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.5 0.0 -0.4 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.3 0.8 0.0 -0.9 -0.0
Mouth/teeth dental problems: Dentures 0.0 0.0 0.0 0.0 -0.2 0.0
Asthma 2.3 4.5 11.8 0.0 1.3 -3.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.3 0.0 0.7 -1.1
Medication: Cholesterol lowering 0.4 0.6 1.7 0.0 -1.3 0.2
Depression (self-reported) 0.1 0.1 0.2 0.0 -0.4 -0.2
Medication: Lansoprazole 0.8 1.0 2.1 0.0 0.9 -1.4
Prospective memory result 0.3 0.3 1.0 0.0 0.2 -1.0
Lung cancer (father) 0.0 0.0 0.0 0.0 0.1 0.0
Illnesses of mother 0.9 1.1 2.4 0.0 1.0 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 3.5 11.3 27.3 0.0 -2.6 5.2
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 0.0 0.1 -0.1
Impedance of arm (left) 0.5 2.2 6.5 0.0 -0.1 2.5
Arm fat mass (right) 0.9 3.8 9.7 0.0 -3.1 1.3
Trunk predicted mass 0.2 1.1 3.3 0.0 -1.8 -0.2
Standing height 0.2 2.2 4.3 0.0 -2.1 1.5
Length of working week for main job 2.2 2.4 4.9 0.0 -1.5 2.2
Exposure to tobacco smoke at home 0.4 0.5 1.0 0.0 -1.0 -0.6
Breastfed as a baby 0.4 0.4 0.7 0.0 -0.8 0.8
Tense / ‘highly strung’ 0.5 0.8 2.3 0.0 -1.5 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.0 0.0 0.1 0.0 0.2 0.3
Hair/balding pattern: Pattern 4 0.2 0.6 1.7 0.0 -1.3 0.3
Birth weight of first child 1.6 2.9 6.4 0.0 -2.5 1.5
Peak expiratory flow (PEF) 2.6 6.0 13.2 0.0 -2.2 3.6
Pulse wave reflection index 0.2 0.2 0.7 0.0 0.8 0.1
Ever highly irritable/argumentative for 2 days 1.2 1.4 3.8 0.0 0.7 -1.9
Loud music exposure frequency 0.1 0.1 0.2 0.0 0.5 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 1.4 0.0 0.7 -1.2
Mouth/teeth dental problems: Bleeding gums 2.4 3.1 7.4 0.0 -2.7 1.4
Blood clot in the leg (DVT) 0.3 0.4 1.3 0.0 0.0 1.1
Medication: Paracetamol 0.9 1.5 3.7 0.0 -1.9 1.0
Headache pain in last month 3.3 5.6 9.8 0.0 -3.1 2.7
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.2 0.0 0.5 0.1
Glaucoma (self-reported) 0.1 0.1 0.2 0.0 -0.1 -0.5
Gout (self-reported) 0.6 0.8 1.3 0.0 1.1 -1.1
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.8 0.0 -0.5 -0.9
Medication: Amlodipine 2.7 3.7 6.6 0.0 2.6 -2.2
Medication: Ventolin 100micrograms inhaler 2.8 3.6 7.6 0.0 1.8 -2.8
Birth weight 2.0 4.3 10.5 0.0 -1.6 3.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 0.0 -0.9 0.7
High blood pressure (siblings) 1.2 1.7 3.7 0.0 1.2 -1.9
Forced vital capacity (FVC), Best measure 1.4 5.2 13.6 0.0 -1.4 3.7
Body fat percentage 1.6 6.3 13.2 0.0 -3.6 2.4
Leg fat percentage (right) 2.2 7.8 17.8 0.0 -4.2 2.4
Arm fat-free mass (right) 0.2 0.8 1.8 0.0 -1.3 -0.8
Exposure to tobacco smoke outside home 0.5 0.7 1.9 0.0 -1.4 0.3
Comparative body size at age 10 1.3 3.7 9.9 0.0 -1.1 3.1
Number of full brothers 0.9 1.1 2.2 0.0 -1.5 1.1
Worry too long after embarrassment 0.0 0.0 0.0 0.0 -0.1 0.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 0.7 0.0 0.8 -0.8
Wheeze or whistling in the chest in last year 2.2 3.8 11.4 0.0 0.3 -3.4
Number of children fathered 0.0 0.0 0.1 0.0 0.0 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.2 0.5 0.0 -0.7 0.2
Age at first live birth 0.3 0.5 1.1 0.0 -0.6 1.0
Pulse wave peak to peak time 0.0 0.0 0.1 0.0 -0.2 0.1
Health satisfaction 0.3 0.3 0.9 0.0 -0.4 -0.9
Shortness of breath walking on level ground 5.6 6.7 14.1 0.0 2.4 -3.8
Qualifications: College or University degree 0.1 0.2 0.4 0.0 -0.7 0.3
Eye problems/disorders: None of the above 0.4 0.5 1.3 0.0 1.1 0.3
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.5 0.0 -1.9 0.3
Emphysema/chronic bronchitis 1.9 2.2 3.4 0.0 1.8 -1.8
Medication for pain relief, constipation, heartburn 0.8 1.4 4.1 0.0 2.0 -0.4
Neck or shoulder pain in last month 0.4 0.6 1.3 0.0 -1.2 -0.7
Medication: Blood pressure 0.3 0.5 1.3 0.0 0.2 -1.1
Angina (self-reported) 0.3 0.5 1.2 0.0 -0.4 -1.1
Migraine (self-reported) 0.1 0.1 0.3 0.0 -0.5 0.1
Medication: Ibuprofen 0.2 0.2 0.5 0.0 0.4 -0.7
Medication: Allopurinol 0.0 0.0 0.1 0.0 -0.2 0.3
Medication: Omeprazole 1.8 2.1 6.3 0.0 -2.5 0.3
Medication: Seretide 50 evohaler 0.1 0.1 0.2 0.0 0.4 -0.4
Mean time to correctly identify matches 1.2 2.3 6.1 0.0 -0.9 2.5
Heart disease (mother) 2.3 2.8 4.3 0.0 -2.0 2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.6 0.0 -0.3 -1.3
Whole body fat mass 1.2 4.9 11.7 0.0 -3.4 1.7
Leg fat mass (right) 1.4 5.4 13.5 0.0 -3.7 1.6
Arm predicted mass (right) 0.2 0.9 1.5 0.0 -1.2 -1.1
Pulse rate, automated reading 4.7 15.3 39.3 0.0 -6.3 2.6
Alcohol intake frequency. 0.1 0.3 0.6 0.0 -0.5 0.7
Comparative height size at age 10 0.6 3.1 6.8 0.0 -2.6 1.6
Number of full sisters 1.7 2.1 3.9 0.0 -2.0 1.5
Suffer from ‘nerves’ 0.1 0.1 0.2 0.0 0.5 0.1
Overall health rating 0.3 0.7 2.2 0.0 0.0 -1.5
Chest pain or discomfort 0.5 0.7 2.0 0.0 -1.4 -0.5
Had major operations 0.2 0.2 0.3 0.0 0.5 0.5
Age at last live birth 0.2 0.3 0.8 0.0 -0.4 0.9
Family relationship satisfaction 0.2 0.3 0.7 0.0 0.4 0.9
Leg pain on walking 0.6 0.7 2.0 0.0 -0.2 -1.4
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.4 0.0 0.6 0.0
Commuting to job workplace: Car/motor vehicle 1.9 2.2 5.0 0.0 -2.2 1.3
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.4 0.0 1.2 0.0
Medication: Aspirin 0.2 0.3 0.6 0.0 -0.8 -0.4
Supplements: Vitamin C 1.3 1.5 3.2 0.0 -1.2 1.8
Knee pain experienced in last month 1.1 1.7 3.0 0.0 -1.5 1.7
Hypertension (Self-reported) 1.2 3.4 5.2 0.0 2.3 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.2 0.0 0.7 -1.1
Illnesses of father: Heart disease 0.1 0.1 0.2 0.0 -0.5 -0.3
Illnesses of siblings: Diabetes 0.9 1.1 2.7 0.0 -1.6 0.9
Smoking status: Previous 0.2 0.2 0.6 0.0 -0.3 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.0 0.0 0.1 0.0 -0.3 -0.1
Whole body fat-free mass 0.2 1.0 3.0 0.0 -1.7 -0.4
Leg fat-free mass (right) 0.1 0.5 1.4 0.0 -1.2 -0.4
Arm fat percentage (left) 0.9 3.7 8.0 0.0 -2.8 1.8
Average weekly red wine intake 0.5 0.7 1.7 0.0 -1.3 0.7
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 0.0 -1.1 0.7
Mood swings 1.0 1.9 4.0 0.0 -2.0 1.3
Loneliness, isolation 1.1 1.5 3.3 0.0 1.8 -1.1
Long-standing illness, disability or infirmity 1.2 1.9 5.3 0.0 0.7 -2.3
Ever had bowel cancer screening 1.2 1.3 3.6 0.0 -0.7 1.9
Diabetes diagnosed by doctor 1.1 1.9 5.1 0.0 -2.3 0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.5 0.0 0.7 -0.7
Friendships satisfaction 1.5 1.8 3.6 0.0 -1.3 1.9
Qualifications: nursing, teaching 0.0 0.0 0.1 0.0 -0.2 0.1
Commuting to job workplace: Walk 0.4 0.4 0.7 0.0 0.8 -0.7
Eye problems/disorders: Cataract 0.3 0.4 1.2 0.0 -1.1 0.1
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.6 0.0 -0.2 0.8
Medication for cholesterol 2.5 3.7 6.4 0.0 -2.2 2.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.9 3.4 6.0 0.0 -2.1 2.4
Back pain experienced in last month 0.8 1.2 3.4 0.0 0.5 -1.9
Mineral and other dietary supplements 2.4 3.2 5.7 0.0 2.4 -2.0
Breast cancer (self-reported) 1.0 1.2 1.9 0.0 -1.4 1.3
Asthma (self-reported) 2.1 4.1 10.8 0.0 1.3 -3.3
Osteoporosis (self-reported) 0.4 0.5 1.5 0.0 -0.0 1.2
Osteoarthritis (self-reported) 0.6 0.7 1.9 0.0 -1.4 -0.5
Medication: Aspirin 0.2 0.2 0.6 0.0 -0.8 -0.4
Medication: Gliclazide 0.0 0.0 0.1 0.0 0.1 -0.3
Illnesses of father: None of the above (group 1) 2.5 3.1 5.6 0.0 -1.9 2.4
Smoking status: Current 2.8 4.4 10.6 0.0 1.6 -3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.6 3.3 9.6 0.0 -0.6 3.1
Whole body water mass 0.2 1.0 2.9 0.0 -1.7 -0.4
Leg predicted mass (right) 0.1 0.5 1.4 0.0 -1.2 -0.4
Arm fat mass (left) 0.8 3.4 8.9 0.0 -3.0 1.1
Number of self-reported non-cancer illnesses 0.8 1.4 4.2 0.0 -0.2 -2.0
Average weekly champagne plus white wine intake 0.0 0.0 0.0 0.0 0.1 -0.1
Miserableness 0.2 0.4 1.0 0.0 1.0 -0.5
Guilty feelings 0.3 0.4 0.6 0.0 -0.8 0.7
Wears glasses or contact lenses 0.3 0.3 0.8 0.0 -0.9 -0.3
Ever taken oral contraceptive pill 1.1 1.3 3.5 0.0 -1.9 0.5
Hearing aid user 0.2 0.2 0.4 0.0 0.4 0.6
Mother’s age at death 0.2 0.3 0.6 0.0 0.8 -0.5
Financial situation satisfaction 0.0 0.0 0.0 0.0 0.1 0.2
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.4 0.0 -0.6 -0.1
Commuting to job workplace: Public transport 1.2 1.4 3.8 0.0 1.9 -0.7
Eye problems/disorders: Glaucoma 0.1 0.2 0.5 0.0 0.1 -0.7
Medication: Blood pressure 2.5 4.8 9.1 0.0 3.0 -2.3
Pain type(s) experienced in last month: Hip pain 0.0 0.0 0.1 0.0 0.1 -0.2
Supplements: Fish oil (including cod liver oil) 2.2 2.8 6.2 0.0 -1.5 2.5
High cholesterol (Self-reported) 0.3 0.4 1.1 0.0 0.5 -1.1
Medication: Bendroflumethiazide 1.9 2.9 6.1 0.0 2.5 -1.6
Medication: Paracetamol 1.6 2.5 5.6 0.0 -2.4 1.4
Medication: Lisinopril 0.0 0.1 0.2 0.0 0.4 -0.1
Medication: Atorvastatin 0.8 1.0 1.8 0.0 -1.1 1.4
Illnesses of father: High blood pressure 0.5 0.6 1.0 0.0 1.0 -0.9
Alcohol drinker status: Never 0.7 0.8 1.6 0.0 -1.2 1.0
Ever smoked 0.3 0.6 1.3 0.0 0.7 -1.1
Basal metabolic rate 0.3 1.6 4.7 0.0 -2.2 0.1
Leg fat percentage (left) 2.1 7.7 17.9 0.0 -4.2 2.3
Arm fat-free mass (left) 0.3 1.7 4.9 0.0 -2.2 -0.2
Number of operations (self-reported) 1.0 1.4 3.1 0.0 -1.8 1.1
Average weekly beer plus cider intake 0.6 0.9 2.6 0.0 -0.4 -1.6
Irritability 1.0 1.7 5.0 0.0 -2.2 -0.0
Risk taking 0.1 0.1 0.2 0.0 -0.4 0.2
Ever had prostate specific antigen (PSA) test 1.0 1.2 3.3 0.0 -0.5 1.8
Fractured/broken bones in last 5 years 0.0 0.1 0.2 0.0 0.4 -0.2
Age started oral contraceptive pill 0.1 0.2 0.3 0.0 -0.5 -0.6
Diastolic blood pressure, automated reading 2.7 8.5 13.3 0.0 3.5 -3.6
Ever depressed for a whole week 1.2 1.5 3.3 0.0 -1.8 1.1
Unable to work because of sickness or disability 0.1 0.2 0.3 0.0 0.6 -0.3
Commuting to job workplace: Cycle 1.3 1.5 4.6 0.0 2.1 -0.2
Myopia 1.2 1.7 3.7 0.0 -1.1 1.9
Vascular/heart problems diagnosed by doctor 1.5 4.1 6.8 0.0 -2.3 2.6
Cholesterol lowering medication 0.3 0.4 0.9 0.0 0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 1.6 2.0 5.9 0.0 -2.4 0.2
Pain experienced in last month 2.0 3.3 6.3 0.0 2.5 -1.9
Supplements: Calcium 1.1 1.2 3.4 0.0 -1.8 0.2
Basal cell carcinoma (self-reported) 1.2 1.4 2.2 0.0 -1.4 1.5
Heart attack/myocardial infarction (self-reported) 1.6 2.1 4.6 0.0 1.3 -2.1
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.4 0.0 0.2 1.2
Heart disease (siblings) 0.3 0.4 1.0 0.0 -1.0 0.2
Alcohol drinker status: Previous 0.0 0.0 0.0 0.0 -0.2 0.1
Pack years of smoking 0.3 0.5 0.8 0.0 -0.8 -0.9
Impedance of whole body 0.4 2.0 6.0 0.0 -0.3 2.4
Leg fat mass (left) 1.3 5.2 13.2 0.0 -3.6 1.5
Arm predicted mass (left) 0.3 1.6 4.9 0.0 -2.2 -0.2