TWAS hub - MYOZ1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.8230	0.0600	8.9e-08	0.066	NA	0.040	NA	-0.003	5.3e-03	NA	2.4e-02	NA	4.0e-01
2	GTEx	Heart Atrial Appendage	0.4320	0.0730	0.0e+00	0.250	NA	0.359	NA	0.378	1.4e-11	NA	5.2e-17	NA	5.4e-18
3	ROSMAP	Brain Pre-frontal Cortex	0.0411	0.0195	6.5e-04	0.005	0.017	0.011	0.015	0.006	6.1e-02	0.0026	1.3e-02	0.0045	5.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	2	3
Systolic Blood Pressure	10.0	49.9	91.8	9.6	-7.6
Systolic blood pressure, automated reading	9.9	28.7	45.4	6.7	-6.4
Hearing difficulty/problems: Yes	7.7	11.8	21.8	-3.7	4.7
Shortness of breath walking on level ground	5.6	6.7	14.1	2.4	-3.8
Pulse rate	5.1	8.6	18.7	-4.3	2.7
Hair/balding pattern: Pattern 2	5.0	6.3	12.1	3.5	-2.6
Forced expiratory volume in 1-second (FEV1)	4.7	15.7	36.4	-3.3	6.0
Pulse rate, automated reading	4.7	15.3	39.3	-6.3	2.6
Average weekly fortified wine intake	4.3	5.0	9.3	2.4	-3.1
Respiratory disease	4.1	9.2	17.8	3.1	-4.2
Primary Biliary Cirrhosis	3.5	5.0	11.8	-3.4	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.3	27.3	-2.6	5.2
Headache pain in last month	3.3	5.6	9.8	-3.1	2.7
Allergy or Eczema	3.1	8.2	18.1	2.5	-4.3
Allergy	3.1	7.1	17.1	-2.0	4.1
Maternal smoking around birth	2.9	4.2	9.1	1.9	-3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.9	3.4	6.0	-2.1	2.4
Breast Cancer	2.8	6.6	10.6	3.1	-3.3
Medication: Metformin	2.8	4.0	10.4	-3.2	1.3
Mouth/teeth dental problems	2.8	4.3	8.8	3.0	-2.0
Medication: Ventolin 100micrograms inhaler	2.8	3.6	7.6	1.8	-2.8
Smoking status: Current	2.8	4.4	10.6	1.6	-3.3
Medication: Amlodipine	2.7	3.7	6.6	2.6	-2.2
Diastolic blood pressure, automated reading	2.7	8.5	13.3	3.5	-3.6
Peak expiratory flow (PEF)	2.6	6.0	13.2	-2.2	3.6
Lung FEV1/FVC ratio	2.5	12.7	21.8	-4.0	4.7
Medication for cholesterol	2.5	3.7	6.4	-2.2	2.5
Illnesses of father: None of the above (group 1)	2.5	3.1	5.6	-1.9	2.4
Medication: Blood pressure	2.5	4.8	9.1	3.0	-2.3
Mouth/teeth dental problems: Bleeding gums	2.4	3.1	7.4	-2.7	1.4
Mineral and other dietary supplements	2.4	3.2	5.7	2.4	-2.0
Asthma	2.3	4.5	11.8	1.3	-3.4
Heart disease (mother)	2.3	2.8	4.3	-2.0	2.1
Blood Eosinophil Count	2.2	16.6	29.4	4.5	-5.4
Length of working week for main job	2.2	2.4	4.9	-1.5	2.2
Leg fat percentage (right)	2.2	7.8	17.8	-4.2	2.4
Wheeze or whistling in the chest in last year	2.2	3.8	11.4	0.3	-3.4
Supplements: Fish oil (including cod liver oil)	2.2	2.8	6.2	-1.5	2.5
Hayfever, allergic rhinitis or eczema	2.1	4.7	10.8	1.8	-3.3
Asthma (self-reported)	2.1	4.1	10.8	1.3	-3.3
Leg fat percentage (left)	2.1	7.7	17.9	-4.2	2.3
Forced vital capacity (FVC)	2.0	7.7	18.7	-2.0	4.3
Birth weight	2.0	4.3	10.5	-1.6	3.2
Pain experienced in last month	2.0	3.3	6.3	2.5	-1.9
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	3.7	-1.9	1.7
Emphysema/chronic bronchitis	1.9	2.2	3.4	1.8	-1.8
Commuting to job workplace: Car/motor vehicle	1.9	2.2	5.0	-2.2	1.3
Medication: Bendroflumethiazide	1.9	2.9	6.1	2.5	-1.6
Current tobacco smoking	1.8	3.0	7.0	1.4	-2.6
Hayfever/allergic rhinitis (self-reported)	1.8	2.4	5.8	1.1	-2.4
Worrier / anxious feelings	1.8	3.3	6.9	-2.6	1.8
Medication: Omeprazole	1.8	2.1	6.3	-2.5	0.3
Cardiovascular Disease	1.7	5.7	9.6	3.1	-2.7
Lung FVC	1.7	8.8	25.7	-0.8	5.1
Number of incorrect matches in round	1.7	2.8	6.6	-1.4	2.6
Number of full sisters	1.7	2.1	3.9	-2.0	1.5
Crohns Disease (2012)	1.6	2.6	7.7	-2.8	0.4
Lupus	1.6	2.4	4.3	-2.1	1.7
Birth weight of first child	1.6	2.9	6.4	-2.5	1.5
Body fat percentage	1.6	6.3	13.2	-3.6	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.6	3.3	9.6	-0.6	3.1
Medication: Paracetamol	1.6	2.5	5.6	-2.4	1.4
Medication: Omeprazole (e.g. Zanprol)	1.6	2.0	5.9	-2.4	0.2
Heart attack/myocardial infarction (self-reported)	1.6	2.1	4.6	1.3	-2.1
Crohns Disease (2017)	1.5	3.3	8.5	-2.9	-1.2
Mean Putamen Volume	1.5	1.7	4.5	2.1	-0.8
Vitamin and mineral supplements	1.5	2.0	3.0	1.7	-1.7
Diabetes (mother)	1.5	1.9	4.6	-2.1	1.1
Waist circumference	1.5	5.5	12.5	-3.5	2.0
Falls in the last year	1.5	2.0	4.1	-1.4	2.0
Friendships satisfaction	1.5	1.8	3.6	-1.3	1.9
Vascular/heart problems diagnosed by doctor	1.5	4.1	6.8	-2.3	2.6
Trunk fat percentage	1.4	5.7	11.2	-3.3	2.4
High blood pressure (mother)	1.4	2.0	4.6	2.1	-1.2
Trunk fat mass	1.4	5.9	13.3	-3.6	2.1
Forced vital capacity (FVC), Best measure	1.4	5.2	13.6	-1.4	3.7
Leg fat mass (right)	1.4	5.4	13.5	-3.7	1.6
Coronary Artery Disease (CAD)	1.3	1.6	4.0	0.9	-2.0
Heart attack	1.3	1.7	3.6	1.2	-1.9
Comparative body size at age 10	1.3	3.7	9.9	-1.1	3.1
Supplements: Vitamin C	1.3	1.5	3.2	-1.2	1.8
Commuting to job workplace: Cycle	1.3	1.5	4.6	2.1	-0.2
Leg fat mass (left)	1.3	5.2	13.2	-3.6	1.5
Fed-up feelings	1.2	2.2	3.6	1.7	-1.9
Chronic bronchitis/emphysema (father)	1.2	1.4	2.8	1.2	-1.7
Arm fat percentage (right)	1.2	4.8	10.0	-3.2	2.1
Ever highly irritable/argumentative for 2 days	1.2	1.4	3.8	0.7	-1.9
High blood pressure (siblings)	1.2	1.7	3.7	1.2	-1.9
Mean time to correctly identify matches	1.2	2.3	6.1	-0.9	2.5
Whole body fat mass	1.2	4.9	11.7	-3.4	1.7
Hypertension (Self-reported)	1.2	3.4	5.2	2.3	-2.3
Long-standing illness, disability or infirmity	1.2	1.9	5.3	0.7	-2.3
Ever had bowel cancer screening	1.2	1.3	3.6	-0.7	1.9
Commuting to job workplace: Public transport	1.2	1.4	3.8	1.9	-0.7
Ever depressed for a whole week	1.2	1.5	3.3	-1.8	1.1
Myopia	1.2	1.7	3.7	-1.1	1.9
Basal cell carcinoma (self-reported)	1.2	1.4	2.2	-1.4	1.5
Townsend deprivation index at recruitment	1.1	1.6	2.4	1.5	-1.5
Qualifications: CSEs or equivalent	1.1	1.4	2.7	1.6	-1.2
Pain all over the body in last month	1.1	1.1	2.9	-1.7	0.7
Knee pain experienced in last month	1.1	1.7	3.0	-1.5	1.7
Loneliness, isolation	1.1	1.5	3.3	1.8	-1.1
Diabetes diagnosed by doctor	1.1	1.9	5.1	-2.3	0.7
Ever taken oral contraceptive pill	1.1	1.3	3.5	-1.9	0.5
Supplements: Calcium	1.1	1.2	3.4	-1.8	0.2
Body Mass Index (BMI) (2010)	1.0	1.3	2.7	-1.6	1.1
Waist Hip Ratio (WHR)	1.0	4.6	7.5	-2.5	2.7
Smoking Status	1.0	2.5	6.2	1.1	-2.5
Hearing difficulty/problems with background noise	1.0	1.6	4.4	-0.7	2.1
Hip circumference	1.0	4.2	10.9	-3.3	1.3
Happiness	1.0	1.3	2.2	-1.3	1.5
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.5	-1.9	0.3
Mood swings	1.0	1.9	4.0	-2.0	1.3
Breast cancer (self-reported)	1.0	1.2	1.9	-1.4	1.3
Number of operations (self-reported)	1.0	1.4	3.1	-1.8	1.1
Irritability	1.0	1.7	5.0	-2.2	-0.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.3	-0.5	1.8
LDL Cholesterol	0.9	1.4	2.6	-1.2	1.6
Taking other prescription medications	0.9	1.4	2.9	-1.2	-1.7
High blood pressure	0.9	2.5	4.1	2.0	-1.9
Weight	0.9	4.3	11.5	-3.4	1.2
Illnesses of mother	0.9	1.1	2.4	1.0	-1.6
Arm fat mass (right)	0.9	3.8	9.7	-3.1	1.3
Medication: Paracetamol	0.9	1.5	3.7	-1.9	1.0
Number of full brothers	0.9	1.1	2.2	-1.5	1.1
Illnesses of siblings: Diabetes	0.9	1.1	2.7	-1.6	0.9
Arm fat percentage (left)	0.9	3.7	8.0	-2.8	1.8
Intelligence (Savage-Jansen 2018)	0.8	2.6	4.9	-1.7	2.2
Irritable Bowel Disease (IBD)	0.8	1.8	5.1	-2.3	-0.6
Reaction Time	0.8	1.6	4.2	-0.7	2.1
Type 2 Diabetes (T2D) (2012)	0.8	0.9	1.3	-1.2	-1.2
Type 2 Diabetes (T2D) (2018)	0.8	1.4	4.2	-2.0	0.3
Frequency of depressed mood in last 2 weeks	0.8	1.1	2.1	-1.4	1.1
Medication: Co-codamol	0.8	0.9	2.3	-0.6	-1.5
Hair/balding pattern: Pattern 3	0.8	1.2	2.2	-1.2	1.5
Medication: Lansoprazole	0.8	1.0	2.1	0.9	-1.4
Medication for pain relief, constipation, heartburn	0.8	1.4	4.1	2.0	-0.4
Back pain experienced in last month	0.8	1.2	3.4	0.5	-1.9
Arm fat mass (left)	0.8	3.4	8.9	-3.0	1.1
Number of self-reported non-cancer illnesses	0.8	1.4	4.2	-0.2	-2.0
Medication: Atorvastatin	0.8	1.0	1.8	-1.1	1.4
Hand grip strength (left)	0.7	2.0	5.3	-0.7	-2.3
Relative age voice broke	0.7	1.1	2.6	1.6	-0.8
Supplements: Glucosamine	0.7	0.9	2.2	-1.5	0.7
Impedance of arm (right)	0.7	3.1	8.9	-0.7	3.0
Alcohol drinker status: Never	0.7	0.8	1.6	-1.2	1.0
Hypothyroidism (self reported)	0.6	1.3	4.0	-0.1	-2.0
Sensitivity / hurt feelings	0.6	1.0	2.9	0.0	1.7
Diabetes (father)	0.6	0.8	2.0	0.7	-1.4
Severe depression (siblings)	0.6	0.6	1.6	-0.6	1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.6	1.0	-1.3
Sitting height	0.6	4.4	10.9	-3.3	1.5
Diabetes (self-reported)	0.6	0.9	2.5	-1.6	0.5
Number of live births	0.6	0.8	1.4	-1.0	1.2
Gout (self-reported)	0.6	0.8	1.3	1.1	-1.1
Comparative height size at age 10	0.6	3.1	6.8	-2.6	1.6
Leg pain on walking	0.6	0.7	2.0	-0.2	-1.4
Osteoarthritis (self-reported)	0.6	0.7	1.9	-1.4	-0.5
Average weekly beer plus cider intake	0.6	0.9	2.6	-0.4	-1.6
Schizophrenia vs Biploar Disorder	0.5	0.6	1.5	1.2	-0.6
Major Depression (MDD)	0.5	0.6	1.3	-1.2	-0.7
HDL Cholesterol	0.5	0.9	2.7	-0.0	1.6
Triglycerides	0.5	0.9	2.6	0.3	-1.6
Ever had hysterectomy (womb removed)	0.5	0.5	1.6	-0.1	1.3
Serious illness, injury or assault to yourself	0.5	0.7	1.9	-1.4	0.2
Body mass index (BMI)	0.5	2.2	6.3	-2.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.3	-1.5	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.5	0.6	1.3	0.7	-1.1
Impedance of arm (left)	0.5	2.2	6.5	-0.1	2.5
Tense / ‘highly strung’	0.5	0.8	2.3	-1.5	0.2
Exposure to tobacco smoke outside home	0.5	0.7	1.9	-1.4	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.6	-0.3	-1.3
Chest pain or discomfort	0.5	0.7	2.0	-1.4	-0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.2	0.7	-1.1
Average weekly red wine intake	0.5	0.7	1.7	-1.3	0.7
Illnesses of father: High blood pressure	0.5	0.6	1.0	1.0	-0.9
Bipolar Disorder (2018)	0.4	0.6	1.5	-1.2	0.5
Impedance of leg (right)	0.4	2.0	5.0	-1.0	2.2
Hand grip strength (right)	0.4	1.2	3.5	-0.4	-1.9
Medication: Cholesterol lowering	0.4	0.6	1.7	-1.3	0.2
Exposure to tobacco smoke at home	0.4	0.5	1.0	-1.0	-0.6
Breastfed as a baby	0.4	0.4	0.7	-0.8	0.8
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.4	0.7	-1.2
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	-0.9	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.7	0.8	-0.8
Eye problems/disorders: None of the above	0.4	0.5	1.3	1.1	0.3
Neck or shoulder pain in last month	0.4	0.6	1.3	-1.2	-0.7
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	1.2	0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-1.1	0.7
Commuting to job workplace: Walk	0.4	0.4	0.7	0.8	-0.7
Osteoporosis (self-reported)	0.4	0.5	1.5	-0.0	1.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.4	0.2	1.2
Impedance of whole body	0.4	2.0	6.0	-0.3	2.4
Worry (Nagel 2018)	0.3	0.6	1.7	-1.3	0.2
Neuroticism (2016)	0.3	0.4	0.8	0.7	-0.9
BMI	0.3	1.8	5.3	-2.3	0.1
Height	0.3	5.0	11.9	-3.5	1.7
Number of treatments/medications taken	0.3	0.5	1.3	-1.1	-0.4
Angina	0.3	0.4	1.0	-0.3	-1.0
Pack years adult smoking proportion	0.3	0.5	1.3	-0.6	-1.1
Age when periods started (menarche)	0.3	0.8	2.2	0.4	-1.5
Stomach or abdominal pain in last month	0.3	0.4	1.1	-1.0	-0.1
Impedance of leg (left)	0.3	1.7	4.4	-0.8	2.1
Alcohol usually taken with meals	0.3	0.5	1.4	-0.0	1.2
Had menopause	0.3	0.4	0.6	0.8	-0.7
Qualifications: None of the above	0.3	0.5	1.4	1.2	-0.4
Alcohol intake versus 10 years previously	0.3	0.5	1.1	1.1	-0.6
Prospective memory result	0.3	0.3	1.0	0.2	-1.0
Blood clot in the leg (DVT)	0.3	0.4	1.3	0.0	1.1
Age at first live birth	0.3	0.5	1.1	-0.6	1.0
Health satisfaction	0.3	0.3	0.9	-0.4	-0.9
Medication: Blood pressure	0.3	0.5	1.3	0.2	-1.1
Angina (self-reported)	0.3	0.5	1.2	-0.4	-1.1
Overall health rating	0.3	0.7	2.2	0.0	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	0.7	-0.7
Eye problems/disorders: Cataract	0.3	0.4	1.2	-1.1	0.1
Guilty feelings	0.3	0.4	0.6	-0.8	0.7
Wears glasses or contact lenses	0.3	0.3	0.8	-0.9	-0.3
High cholesterol (Self-reported)	0.3	0.4	1.1	0.5	-1.1
Ever smoked	0.3	0.6	1.3	0.7	-1.1
Basal metabolic rate	0.3	1.6	4.7	-2.2	0.1
Arm fat-free mass (left)	0.3	1.7	4.9	-2.2	-0.2
Cholesterol lowering medication	0.3	0.4	0.9	0.9	-0.6
Heart disease (siblings)	0.3	0.4	1.0	-1.0	0.2
Pack years of smoking	0.3	0.5	0.8	-0.8	-0.9
Arm predicted mass (left)	0.3	1.6	4.9	-2.2	-0.2
Depressed Affect (Nagel 2018)	0.2	0.5	1.3	0.5	-1.1
Depression (Nagel 2018)	0.2	0.2	0.5	0.7	-0.5
Alzheimer’s Disease (in mother)	0.2	0.2	0.3	0.5	0.6
Alzheimer’s Disease (in father)	0.2	0.2	0.7	0.0	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.1	-1.0	0.8
Ovarian Cancer	0.2	0.3	0.9	0.2	-0.9
Bipolar Disorder (2011)	0.2	0.2	0.7	-0.2	-0.8
Ulcerative Colitis	0.2	0.3	0.5	-0.7	0.7
Blood Platelet Count	0.2	2.2	3.6	1.7	-1.9
Blood White Count	0.2	1.4	4.1	-0.1	-2.0
Heel T-Score	0.2	1.2	2.6	1.0	1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	-0.7	-0.5
Leg fat-free mass (left)	0.2	0.9	2.6	-1.6	-0.1
Medication: Levothyroxine sodium	0.2	0.4	1.1	-1.1	-0.2
Had other major operations	0.2	0.2	0.6	-0.8	0.1
Medication: Ramipril	0.2	0.3	0.9	-0.1	-0.9
Fluid intelligence score	0.2	0.3	1.0	-1.0	0.1
Trunk fat-free mass	0.2	1.2	3.5	-1.9	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.8	-0.9	-0.0
Trunk predicted mass	0.2	1.1	3.3	-1.8	-0.2
Standing height	0.2	2.2	4.3	-2.1	1.5
Hair/balding pattern: Pattern 4	0.2	0.6	1.7	-1.3	0.3
Pulse wave reflection index	0.2	0.2	0.7	0.8	0.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.8	-0.5	-0.9
Arm fat-free mass (right)	0.2	0.8	1.8	-1.3	-0.8
Medication: Ibuprofen	0.2	0.2	0.5	0.4	-0.7
Arm predicted mass (right)	0.2	0.9	1.5	-1.2	-1.1
Had major operations	0.2	0.2	0.3	0.5	0.5
Age at last live birth	0.2	0.3	0.8	-0.4	0.9
Family relationship satisfaction	0.2	0.3	0.7	0.4	0.9
Medication: Aspirin	0.2	0.3	0.6	-0.8	-0.4
Smoking status: Previous	0.2	0.2	0.6	-0.3	0.8
Whole body fat-free mass	0.2	1.0	3.0	-1.7	-0.4
Medication: Aspirin	0.2	0.2	0.6	-0.8	-0.4
Whole body water mass	0.2	1.0	2.9	-1.7	-0.4
Miserableness	0.2	0.4	1.0	1.0	-0.5
Hearing aid user	0.2	0.2	0.4	0.4	0.6
Mother’s age at death	0.2	0.3	0.6	0.8	-0.5
Schizophrenia (2018)	0.1	0.2	0.6	0.7	0.1
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.2	0.5
Ulcerative Colitis (UC)	0.1	0.3	0.7	-0.8	0.3
Prostate Cancer	0.1	0.2	0.5	0.3	-0.7
Fasting Glucose	0.1	0.2	0.5	-0.0	-0.7
Rheumatoid Arthritis	0.1	0.1	0.3	-0.3	0.5
Chronotype (morning person)	0.1	0.2	0.6	0.7	0.3
Tanning	0.1	0.6	1.6	0.5	-1.3
Average weekly spirits intake	0.1	0.1	0.3	-0.6	-0.1
Eye problems/disorders: Diabetes related eye disease	0.1	0.2	0.4	-0.7	-0.2
Medication for hormone replacement therapy	0.1	0.1	0.1	0.4	-0.4
Supplements: Zinc	0.1	0.1	0.3	-0.6	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.7	0.6
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.3	0.5	0.3
Multivitamins +/- minerals	0.1	0.2	0.5	-0.7	0.1
Leg predicted mass (left)	0.1	0.8	2.3	-1.5	-0.2
Nervous feelings	0.1	0.1	0.3	-0.5	0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	-0.5	0.8
Financial difficulties in last 2 years	0.1	0.1	0.2	0.2	-0.5
Medication: Simvastatin	0.1	0.1	0.2	-0.1	-0.5
Illnesses of siblings	0.1	0.2	0.3	0.4	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.5	-0.6
Noisy workplace	0.1	0.1	0.3	0.4	-0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	-0.4	0.7
Depression (self-reported)	0.1	0.1	0.2	-0.4	-0.2
Loud music exposure frequency	0.1	0.1	0.2	0.5	0.1
Glaucoma (self-reported)	0.1	0.1	0.2	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.5	-0.7	0.2
Qualifications: College or University degree	0.1	0.2	0.4	-0.7	0.3
Migraine (self-reported)	0.1	0.1	0.3	-0.5	0.1
Medication: Seretide 50 evohaler	0.1	0.1	0.2	0.4	-0.4
Alcohol intake frequency.	0.1	0.3	0.6	-0.5	0.7
Suffer from ‘nerves’	0.1	0.1	0.2	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.4	0.6	0.0
Illnesses of father: Heart disease	0.1	0.1	0.2	-0.5	-0.3
Leg fat-free mass (right)	0.1	0.5	1.4	-1.2	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.6	-0.2	0.8
Leg predicted mass (right)	0.1	0.5	1.4	-1.2	-0.4
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.6	-0.1
Eye problems/disorders: Glaucoma	0.1	0.2	0.5	0.1	-0.7
Risk taking	0.1	0.1	0.2	-0.4	0.2
Age started oral contraceptive pill	0.1	0.2	0.3	-0.5	-0.6
Unable to work because of sickness or disability	0.1	0.2	0.3	0.6	-0.3
Bipolar Disorder or Schizophrenia	0.0	0.1	0.1	-0.2	0.4
Neuroticism (Nagel 2018)	0.0	0.1	0.3	-0.1	-0.6
Age at First Birth	0.0	0.1	0.1	0.3	-0.3
HbA1C	0.0	0.0	0.1	0.2	-0.0
Schizophrenia (2014)	0.0	0.1	0.1	0.4	0.2
Blood Red Count	0.0	0.3	0.7	0.5	-0.8
Neuroticism	0.0	0.1	0.2	-0.0	-0.4
Hair Pigment	0.0	0.3	0.6	0.8	-0.4
Relative age of first facial hair	0.0	0.1	0.1	0.3	-0.4
Ever used hormone-replacement therapy (HRT)	0.0	0.1	0.1	0.2	0.4
Bilateral oophorectomy (both ovaries removed)	0.0	0.0	0.0	0.1	0.0
Medication: Atenolol	0.0	0.0	0.0	-0.1	-0.2
Past tobacco smoking	0.0	0.0	0.1	-0.1	0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.2	-0.3
Neuroticism score	0.0	0.1	0.2	-0.5	0.2
Time employed in main current job	0.0	0.0	0.0	0.1	-0.0
Father’s age at death	0.0	0.1	0.1	0.4	-0.1
Mouth/teeth dental problems: Dentures	0.0	0.0	0.0	-0.2	0.0
Lung cancer (father)	0.0	0.0	0.0	0.1	0.0
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	0.1	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.2	0.3
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.2	0.5	0.1
Worry too long after embarrassment	0.0	0.0	0.0	-0.1	0.0
Number of children fathered	0.0	0.0	0.1	0.0	-0.3
Pulse wave peak to peak time	0.0	0.0	0.1	-0.2	0.1
Medication: Allopurinol	0.0	0.0	0.1	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.0	0.0	0.1	-0.3	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.1	-0.2	0.1
Medication: Gliclazide	0.0	0.0	0.1	0.1	-0.3
Average weekly champagne plus white wine intake	0.0	0.0	0.0	0.1	-0.1
Financial situation satisfaction	0.0	0.0	0.0	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.1	0.1	-0.2
Medication: Lisinopril	0.0	0.1	0.2	0.4	-0.1
Fractured/broken bones in last 5 years	0.0	0.1	0.2	0.4	-0.2
Alcohol drinker status: Previous	0.0	0.0	0.0	-0.2	0.1

Hub : Genes

MYOZ1

Models

Trait associations