Hub : Genes

SEC24C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0440	0.0220	2.9e-03	0.016	NA	-0.001	NA	0.004	1.6e-02	NA	3.6e-01	NA	1.3e-01
2	GTEx	Cells Transformed fibroblasts	0.0550	0.0290	6.4e-03	0.011	NA	0.008	NA	0.012	4.4e-02	NA	7.3e-02	NA	3.9e-02
3	GTEx	Esophagus Mucosa	0.1100	0.0370	7.2e-07	0.080	NA	0.090	NA	0.095	5.1e-06	NA	1.3e-06	NA	6.7e-07
4	TCGA	Breast Invasive Carcinoma	0.0367	0.0254	1.3e-05	0.022	0.027	0.025	NA	0.025	2.3e-05	2.6e-06	6.0e-06	NA	4.5e-06
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0720	0.0500	5.8e-04	0.074	0.068	0.066	NA	0.056	5.1e-05	9.4e-05	1.2e-04	NA	3.7e-04
6	TCGA	Lung Adenocarcinoma	0.0229	0.0173	4.0e-03	0.014	0.010	0.014	NA	0.007	8.8e-03	1.9e-02	8.5e-03	NA	4.2e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.4	0.6	1.2	0.0	-0.1	0.7	0.8	1.1	1.0
Bipolar Disorder or Schizophrenia	0.0	0.1	0.4	0.6	0.1	-0.5	0.1	0.0	0.1
Depressed Affect (Nagel 2018)	0.5	1.1	2.0	-1.4	-1.4	0.9	-1.1	-0.6	-0.7
Depression (Nagel 2018)	0.2	0.2	0.5	0.2	-0.3	-0.2	-0.7	-0.7	-0.6
Intelligence (Savage-Jansen 2018)	2.2	6.9	16.3	0.8	2.5	-0.9	4.0	2.7	3.2
Neuroticism (Nagel 2018)	0.1	0.3	0.6	-0.8	-0.2	0.3	0.6	0.6	0.6
Schizophrenia (2018)	0.3	0.6	1.4	0.8	0.2	-1.2	-0.4	-0.8	-0.8
Schizophrenia vs Biploar Disorder	1.4	1.8	3.6	-0.4	-0.7	-0.7	-1.5	-1.9	-1.9
Worry (Nagel 2018)	0.9	1.8	3.7	-0.9	0.1	0.7	1.6	1.9	1.9
Alzheimer’s Disease (in mother)	0.6	0.7	1.4	0.3	1.0	-1.2	1.1	0.3	0.5
Alzheimer’s Disease (in father)	2.1	2.2	4.7	-1.2	-1.9	1.2	-2.2	-1.0	-1.2
Alzheimer’s Disease (including proxy)	0.1	0.2	0.4	-0.1	0.2	-0.0	0.5	0.6	0.7
Crohns Disease (2017)	9.9	21.7	42.5	-6.0	-6.5	5.9	-4.0	0.6	-0.6
Irritable Bowel Disease (IBD)	5.1	12.1	25.7	-4.6	-5.1	4.3	-2.7	0.5	-0.2
Ulcerative Colitis (UC)	0.6	1.2	2.7	-1.4	-1.7	1.3	-0.4	0.5	0.4
Major Depression (MDD)	2.8	3.4	7.0	-2.4	-2.3	2.6	-1.6	0.4	-0.1
Reaction Time	0.4	0.8	1.9	-1.0	0.1	-0.0	1.4	0.9	1.1
Verbal and Numeric Reasoning (VNR)	1.4	3.3	7.2	0.3	1.7	-0.4	2.7	2.0	2.3
Breast Cancer	1.1	2.5	6.8	0.3	0.2	-2.6	-0.1	-2.2	-1.9
Ovarian Cancer	1.7	2.3	4.4	-1.8	-2.1	0.5	-1.4	-1.3	-1.4
Prostate Cancer	0.3	0.5	0.9	0.9	0.2	-0.2	-0.9	-0.6	-0.7
Age at First Birth	0.2	0.2	1.2	0.1	0.2	-1.1	0.4	-0.1	-0.2
Bipolar Disorder (2011)	0.8	0.8	2.3	-0.8	-1.5	1.2	-0.5	0.3	0.1
Body Mass Index (BMI) (2010)	1.0	1.4	2.9	-0.2	0.5	0.9	1.2	1.7	1.7
Coronary Artery Disease (CAD)	5.2	6.2	11.8	-2.1	-3.3	1.2	-3.4	-1.8	-2.3
Crohns Disease (2012)	5.1	8.3	16.5	-3.8	-3.7	4.1	-1.8	1.1	0.4
Mean Putamen Volume	2.3	2.6	7.2	1.5	1.6	-2.7	0.4	-1.5	-1.2
Fasting Glucose	1.3	1.6	2.2	-1.5	-1.3	1.5	-1.4	-0.8	-0.8
HbA1C	0.3	0.3	0.7	-0.7	-0.4	0.4	-0.9	-0.5	-0.4
HDL Cholesterol	1.8	3.0	6.5	1.0	2.1	-2.1	2.5	0.8	1.1
LDL Cholesterol	0.4	0.6	1.3	-0.4	-0.2	0.9	0.4	1.1	1.0
Lupus	1.5	2.2	5.0	-2.2	-1.1	1.3	0.6	1.7	1.5
Neuroticism (2016)	0.1	0.1	0.2	-0.1	-0.4	-0.5	-0.4	-0.3	-0.4
Primary Biliary Cirrhosis	3.8	5.4	16.2	-2.2	-2.2	4.0	-1.1	1.8	1.3
Rheumatoid Arthritis	1.2	1.7	3.0	0.8	1.4	-0.7	1.7	1.3	1.4
Schizophrenia (2014)	0.2	0.4	0.6	0.5	-0.3	-0.7	-0.6	-0.8	-0.8
Triglycerides	1.2	2.0	4.4	-0.7	-1.7	1.7	-2.1	-0.6	-1.0
Type 2 Diabetes (T2D) (2012)	3.0	3.5	7.3	-2.4	-2.4	2.7	-1.4	0.1	-0.7
Ulcerative Colitis	0.2	0.3	0.6	-0.5	-0.3	0.3	0.6	0.6	0.8
Blood Eosinophil Count	1.8	13.8	28.5	1.3	-0.9	-1.3	-4.9	-5.1	-5.3
Blood Platelet Count	0.5	5.5	17.4	4.2	2.8	-2.5	1.1	-0.2	0.1
Blood Red Count	0.2	1.7	3.2	-1.2	-1.1	1.1	-1.8	-1.0	-1.4
Blood White Count	0.5	3.6	10.6	0.0	-1.8	2.2	-3.2	-0.9	-1.5
Heel T-Score	1.3	10.4	21.0	3.2	4.6	-3.3	3.8	1.3	2.0
BMI	0.5	2.7	10.8	-1.0	-0.8	3.3	-1.2	1.4	0.9
Height	0.4	7.8	13.5	-3.1	-3.6	3.7	-0.3	2.6	1.9
Waist Hip Ratio (WHR)	0.5	2.0	4.7	-0.9	-0.2	1.3	1.0	2.2	2.0
Systolic Blood Pressure	6.8	34.0	57.9	5.3	3.2	-7.3	-2.6	-7.6	-6.9
Smoking Status	2.2	5.2	10.9	-1.4	-2.6	1.0	-3.3	-2.0	-2.5
Allergy or Eczema	3.3	8.8	16.6	-1.4	-2.5	0.5	-4.1	-3.5	-4.0
Cardiovascular Disease	1.8	5.9	12.3	3.5	2.6	-3.2	0.4	-1.8	-1.4
Hypothyroidism (self reported)	1.3	2.9	7.1	-2.3	-2.7	1.6	-1.4	-0.5	-0.8
Respiratory disease	4.0	9.0	19.1	-0.5	-2.1	0.2	-4.4	-3.6	-4.1
Type 2 Diabetes (T2D) (2018)	1.5	2.8	6.1	-2.1	-1.8	2.5	-0.4	1.4	1.1
Lung FEV1/FVC ratio	3.8	19.3	42.9	-0.6	2.0	0.1	6.5	5.5	6.1
Lung FVC	7.2	36.9	62.4	5.7	7.3	-5.4	7.9	4.0	5.2
Neuroticism	0.3	0.8	2.8	-1.7	-1.1	0.6	-0.4	0.1	-0.1
Chronotype (morning person)	1.1	2.5	5.6	1.9	2.4	-1.8	1.5	0.2	0.5
Hair Pigment	0.0	0.2	0.4	0.2	0.6	-0.6	0.2	-0.4	-0.3
Tanning	0.1	1.3	3.1	-0.3	-1.2	0.6	-1.8	-1.1	-1.4
Hand grip strength (left)	0.7	1.9	4.5	-0.9	-2.0	2.1	-1.4	0.0	-0.3
Number of treatments/medications taken	0.7	1.2	2.4	-1.6	-1.2	1.5	-0.6	0.6	0.3
Average weekly spirits intake	0.2	0.2	0.7	-0.2	-0.2	0.8	0.1	0.6	0.5
Sensitivity / hurt feelings	1.4	2.3	4.2	0.8	2.1	-1.5	2.0	1.0	1.3
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.1	-1.0	-0.9	1.2	0.5	1.4	1.4
Hearing difficulty/problems: Yes	3.8	5.8	11.6	-2.3	-0.8	2.7	1.0	3.4	3.0
Relative age of first facial hair	0.9	1.9	2.9	-1.3	-1.7	0.4	-1.7	-1.3	-1.5
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	2.6	-1.6	-1.4	1.1	-0.9	-0.7	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	0.9	1.0	0.8	-0.9	0.4	-0.2	-0.0
Ever had hysterectomy (womb removed)	1.3	1.5	2.6	0.9	1.6	-1.4	1.6	0.6	0.9
Systolic blood pressure, automated reading	5.9	17.3	38.1	2.6	1.1	-3.9	-3.0	-6.2	-5.8
Eye problems/disorders: Diabetes related eye disease	1.4	1.5	3.4	-1.2	-1.5	1.8	-1.3	-0.2	-0.4
Angina	1.2	1.6	4.6	-0.6	-1.1	1.4	-2.1	-0.6	-1.0
Medication for hormone replacement therapy	0.6	0.7	1.2	-1.1	-0.8	-0.0	-1.0	-0.9	-0.9
Vitamin and mineral supplements	1.2	1.6	3.3	0.7	-0.4	-0.4	-1.6	-1.8	-1.8
Supplements: Zinc	0.1	0.1	0.4	0.1	-0.2	0.6	0.2	0.4	0.2
Medication: Co-codamol	2.8	3.2	6.9	-2.3	-2.6	1.8	-1.7	-0.4	-0.8
Medication: Metformin	3.2	4.5	9.0	-2.6	-1.8	3.0	-0.1	2.0	1.8
Diabetes (father)	0.2	0.2	0.5	0.7	0.1	0.5	-0.5	-0.5	-0.5
Diabetes (mother)	1.9	2.5	4.0	-1.5	-1.3	1.9	0.4	2.0	1.8
Severe depression (siblings)	1.1	1.3	2.0	0.7	1.3	0.1	1.4	1.2	1.4
Pack years adult smoking proportion	2.6	4.0	10.2	-0.5	-2.2	2.4	-3.2	-0.8	-1.4
Impedance of leg (right)	1.1	5.3	13.3	0.4	1.4	-1.5	3.7	2.5	2.8
Leg fat-free mass (left)	0.7	3.7	10.3	-1.1	-2.1	3.2	-2.4	0.2	-0.4
Trunk fat percentage	1.0	4.1	10.2	-1.6	-0.3	3.2	0.2	2.6	2.2
Hand grip strength (right)	0.7	2.0	3.9	-0.8	-1.8	2.0	-1.9	-0.2	-0.6
Townsend deprivation index at recruitment	2.3	3.3	7.1	-0.3	-1.3	0.4	-2.7	-2.1	-2.5
Current tobacco smoking	2.9	4.8	13.4	-0.2	-1.8	0.9	-3.7	-2.2	-2.6
Average weekly fortified wine intake	2.7	3.2	5.4	2.1	1.0	-1.8	-0.9	-2.3	-2.1
Maternal smoking around birth	4.1	5.9	11.7	-0.6	-2.3	1.1	-3.4	-2.7	-3.1
Fed-up feelings	0.9	1.6	3.3	0.3	-0.5	-0.1	-1.8	-1.6	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.1	-0.5	-1.3	0.1	-2.0	-1.5	-1.6
Relative age voice broke	1.5	2.2	5.0	-0.5	-0.7	-0.5	-1.7	-2.1	-2.2
Taking other prescription medications	3.1	4.7	9.7	-2.9	-3.1	2.7	-1.7	-0.1	-0.4
Age when periods started (menarche)	1.3	3.0	6.3	-1.2	-2.5	1.6	-2.4	-0.8	-1.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.2	0.5	0.4	0.7	-0.2	0.3	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	0.2	0.7	0.1	1.0	1.0	1.2
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.8	0.6	0.4	-0.9	0.4	-0.0	0.1
Qualifications: CSEs or equivalent	0.7	0.9	2.0	0.6	0.3	-1.4	-0.5	-1.1	-1.1
Serious illness, injury or assault to yourself	0.8	0.9	2.6	-0.8	-1.3	1.6	-0.7	0.4	0.3
High blood pressure	1.1	3.0	5.9	2.4	1.9	-2.4	0.4	-1.4	-0.9
Hayfever, allergic rhinitis or eczema	2.5	5.4	9.8	-1.6	-2.2	0.5	-3.1	-2.6	-2.9
Multivitamins +/- minerals	0.3	0.3	0.7	-0.5	-0.1	0.4	0.5	0.8	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.1	-0.4	1.0	-0.2	1.0	0.7
Supplements: Glucosamine	3.0	3.9	11.1	-3.3	-2.5	1.9	-0.2	1.4	1.1
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	8.1	0.2	0.9	0.4	2.6	2.7	2.9
Medication: Atenolol	0.2	0.3	1.3	-1.2	-0.6	0.2	-0.1	0.2	0.2
Medication: Levothyroxine sodium	0.8	1.4	4.8	-2.2	-1.6	0.9	-0.0	0.3	0.2
Sitting height	0.8	5.7	11.6	-1.9	-2.0	3.4	0.4	3.0	2.5
Chronic bronchitis/emphysema (father)	0.9	1.0	2.0	-1.0	-0.4	-0.8	-0.8	-1.3	-1.4
High blood pressure (mother)	3.0	4.2	10.1	2.6	2.3	-3.2	1.5	-0.7	-0.3
Body mass index (BMI)	0.7	3.1	12.3	-1.2	-0.8	3.5	-1.2	1.4	0.9
Impedance of leg (left)	1.1	5.3	12.6	0.5	1.7	-1.6	3.5	2.4	2.8
Leg predicted mass (left)	0.7	3.7	9.9	-1.1	-2.1	3.1	-2.5	0.1	-0.5
Trunk fat mass	1.2	5.1	14.7	-1.9	-1.0	3.8	-0.3	2.6	2.1
Waist circumference	1.3	4.8	16.1	-1.5	-1.0	4.0	-0.6	2.4	1.8
Number of incorrect matches in round	1.1	1.8	3.6	-0.3	0.7	0.4	1.8	1.8	1.9
Past tobacco smoking	0.5	0.8	3.3	1.8	1.3	-0.0	0.1	0.3	0.3
Alcohol usually taken with meals	1.1	1.7	3.0	1.3	1.6	-1.7	1.6	0.3	0.7
Nervous feelings	0.3	0.6	1.4	-0.2	0.4	0.3	1.0	1.1	1.2
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	5.8	-1.9	-2.1	2.4	-1.1	0.8	0.5
Hearing difficulty/problems with background noise	0.5	0.8	2.1	-1.4	-0.7	0.5	0.5	0.8	0.8
Hair/balding pattern: Pattern 2	4.1	5.2	11.7	0.7	0.2	-1.9	-2.1	-3.4	-3.3
Had menopause	1.2	1.5	3.0	0.1	-0.8	0.4	-1.7	-1.6	-1.6
Had other major operations	0.9	1.1	3.4	-1.8	-1.1	0.8	0.3	0.9	0.8
Forced vital capacity (FVC)	3.3	12.9	25.0	2.5	3.1	-2.0	5.0	3.8	4.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.8	1.4	0.6	0.9	-0.1	1.0	1.1	1.2
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-1.2	-0.8	0.9	-0.2	-0.1	-0.1
Qualifications: None of the above	0.6	1.3	2.8	-0.0	-0.4	-0.1	-1.6	-1.6	-1.7
Financial difficulties in last 2 years	0.1	0.2	0.5	-0.7	-0.6	-0.0	-0.3	0.0	-0.1
Mouth/teeth dental problems	2.9	4.4	7.7	2.0	0.9	-2.3	-1.4	-2.8	-2.6
Heart attack	1.1	1.4	2.4	1.5	0.2	-0.2	-1.6	-1.4	-1.4
Allergy	4.3	9.9	20.6	1.6	3.2	-1.1	4.5	3.2	3.8
Pain all over the body in last month	1.2	1.3	4.0	-1.0	-1.0	2.0	-0.9	0.7	0.5
Diabetes (self-reported)	1.1	1.7	4.2	-1.6	-1.5	2.1	-0.3	0.9	0.7
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.3	-0.4	-1.2	0.1	-1.5	-1.3	-1.5
Medication: Ramipril	0.3	0.4	1.1	-0.4	-0.6	0.4	-1.1	-0.3	-0.4
Medication: Simvastatin	0.0	0.0	0.0	-0.1	0.1	-0.1	-0.2	-0.1	-0.0
Fluid intelligence score	1.2	2.4	4.6	0.6	1.4	-0.1	2.1	1.8	2.1
Illnesses of siblings	1.3	1.9	4.7	2.1	2.2	-1.1	0.8	0.2	0.4
Neuroticism score	0.3	0.6	1.1	-1.1	-0.4	0.2	0.7	0.9	0.9
Weight	1.0	5.0	17.1	-1.7	-1.6	4.1	-1.1	2.1	1.5
Impedance of arm (right)	0.4	1.9	4.9	-0.6	0.7	-1.3	2.2	1.2	1.5
Arm fat percentage (right)	0.9	3.4	9.8	-1.5	-0.3	3.1	-0.1	2.2	1.8
Trunk fat-free mass	0.4	2.5	7.7	-0.9	-1.9	2.8	-1.5	0.7	0.2
Hip circumference	1.1	4.7	16.9	-1.4	-1.2	4.1	-0.9	2.2	1.6
Time employed in main current job	0.3	0.4	0.6	0.7	0.4	-0.7	-0.2	-0.8	-0.7
Alcohol intake versus 10 years previously	1.1	1.6	2.7	-1.2	-1.6	0.3	-1.6	-1.2	-1.3
Father’s age at death	0.6	0.9	1.7	1.2	0.9	-1.3	1.0	-0.4	-0.1
Worrier / anxious feelings	2.2	4.1	8.8	-0.6	0.2	0.9	2.5	2.9	3.0
Frequency of tiredness / lethargy in last 2 weeks	4.2	6.9	12.7	-3.0	-3.6	2.7	-3.1	-0.8	-1.5
Falls in the last year	0.4	0.6	1.4	-0.3	0.3	0.3	0.7	1.2	1.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.8	-0.0	0.9	-0.2	1.7	1.3	1.5
Number of live births	1.2	1.6	3.2	0.7	0.8	-0.2	1.8	1.6	1.7
Forced expiratory volume in 1-second (FEV1)	7.1	24.0	47.7	2.6	4.1	-1.9	6.9	5.6	6.2
Pulse rate	5.3	8.9	19.4	-3.3	-2.7	4.4	-0.3	3.0	2.5
Happiness	0.5	0.6	1.6	-0.9	-0.7	1.3	-0.2	0.8	0.6
Noisy workplace	1.2	1.5	3.5	-0.8	-1.0	1.2	-1.9	-1.0	-1.3
Qualifications: A levels/AS levels or equivalent	0.7	1.6	2.9	1.6	1.2	-1.1	1.7	0.7	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	-0.4	-0.4	0.8	0.0	0.7	0.6
Mouth/teeth dental problems: Dentures	0.1	0.2	0.6	-0.8	-0.4	0.5	-0.1	-0.2	-0.1
Asthma	3.9	7.7	17.1	-1.7	-3.1	1.7	-4.1	-2.3	-3.0
Medication: Ibuprofen (e.g. Nurofen)	2.5	3.2	9.2	-0.0	-1.1	0.6	-3.0	-1.8	-2.2
Medication: Cholesterol lowering	0.4	0.6	1.5	-0.1	0.3	0.5	0.7	1.2	1.2
Depression (self-reported)	0.1	0.2	0.5	-0.6	-0.1	0.7	0.1	0.2	0.1
Medication: Lansoprazole	0.6	0.6	1.2	0.5	-0.0	-0.6	-1.0	-1.0	-1.1
Prospective memory result	0.1	0.1	0.2	0.4	-0.3	0.5	-0.4	0.1	-0.1
Lung cancer (father)	0.0	0.0	0.0	-0.1	-0.1	-0.0	-0.1	-0.1	-0.0
Illnesses of mother	2.9	3.5	6.7	-1.0	-1.8	0.9	-2.6	-2.0	-2.3
Forced expiratory volume in 1-second (FEV1), Best measure	6.3	20.1	38.5	3.0	4.1	-1.9	6.2	4.8	5.4
Pulse wave Arterial Stiffness index	0.3	0.3	0.6	-0.7	-0.5	0.7	-0.4	-0.4	-0.4
Impedance of arm (left)	0.4	1.7	4.2	-0.3	1.1	-1.8	2.0	0.6	1.0
Arm fat mass (right)	1.0	4.3	14.8	-1.8	-1.2	3.8	-1.0	1.8	1.3
Trunk predicted mass	0.5	2.6	7.8	-0.9	-2.0	2.8	-1.6	0.7	0.1
Standing height	0.2	1.9	3.5	-1.1	-1.9	1.8	-0.1	1.5	1.2
Length of working week for main job	1.1	1.2	3.3	0.8	0.6	0.1	0.8	1.8	1.6
Exposure to tobacco smoke at home	4.5	5.1	9.2	-2.7	-3.0	2.5	-2.6	-0.3	-0.9
Breastfed as a baby	1.9	2.4	6.0	0.8	1.1	-0.9	2.4	1.5	1.8
Tense / ‘highly strung’	0.6	1.0	1.9	-0.9	-0.8	1.0	0.5	1.4	1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.0	1.0	1.5	-1.1	1.7	0.7	1.0
Hair/balding pattern: Pattern 4	0.4	1.1	2.5	-0.2	-0.2	1.6	0.3	1.4	1.3
Birth weight of first child	1.1	2.1	4.6	-0.2	-0.2	1.4	1.3	2.2	2.0
Peak expiratory flow (PEF)	3.4	7.9	17.7	0.3	1.8	-0.6	4.2	3.4	3.8
Pulse wave reflection index	0.5	0.6	1.5	0.5	0.9	-1.2	1.1	-0.1	0.1
Ever highly irritable/argumentative for 2 days	3.6	4.3	7.5	-1.9	-2.6	2.1	-2.7	-1.1	-1.6
Loud music exposure frequency	0.5	0.6	1.3	-0.3	-0.3	-0.6	-0.6	-1.1	-1.1
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.1	0.1	-0.5	-0.1	-0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	3.9	5.1	7.2	-2.7	-1.9	2.5	1.0	2.6	2.4
Blood clot in the leg (DVT)	1.2	1.5	2.7	1.6	1.4	-1.3	1.2	0.7	0.9
Medication: Paracetamol	1.8	3.0	6.4	-2.5	-2.0	2.4	-0.7	1.0	0.7
Headache pain in last month	2.0	3.5	6.6	-1.7	-0.3	2.2	1.1	2.6	2.4
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.1	-0.2	0.3	-0.2	-0.4	-0.5
Glaucoma (self-reported)	0.2	0.3	0.7	-0.5	-0.8	0.7	-0.4	0.1	-0.0
Gout (self-reported)	0.9	1.2	2.9	1.7	0.9	-1.2	-0.7	-0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	1.5	2.9	7.3	-2.7	-2.7	1.5	-0.9	-0.1	-0.4
Medication: Amlodipine	2.2	3.1	4.6	1.8	1.7	-1.7	-1.0	-2.1	-2.0
Medication: Ventolin 100micrograms inhaler	2.9	3.7	6.0	-1.5	-2.0	0.2	-2.2	-2.3	-2.4
Birth weight	1.6	3.5	6.5	0.3	1.7	-1.0	2.5	2.2	2.4
Chronic bronchitis/emphysema (mother)	0.7	0.8	3.3	-1.8	-1.1	0.4	-0.3	0.2	-0.0
High blood pressure (siblings)	0.6	0.8	1.4	-0.7	-1.2	-0.3	-0.7	-1.1	-1.2
Forced vital capacity (FVC), Best measure	3.2	11.6	20.5	3.0	3.2	-2.0	4.5	3.3	3.8
Body fat percentage	1.3	4.9	11.4	-1.6	-0.2	3.4	0.5	3.0	2.6
Leg fat percentage (right)	1.9	6.9	14.4	-1.3	-0.0	3.4	1.4	3.8	3.5
Arm fat-free mass (right)	0.5	2.6	8.4	-0.7	-1.7	2.9	-2.0	0.3	-0.2
Exposure to tobacco smoke outside home	5.8	7.7	14.2	-3.8	-3.7	3.5	-2.3	0.0	-0.5
Comparative body size at age 10	3.3	9.2	19.2	2.8	4.4	-2.3	3.6	2.0	2.5
Number of full brothers	1.8	2.3	5.4	-1.7	-1.7	2.3	-1.3	0.9	0.3
Worry too long after embarrassment	0.6	1.1	2.7	-0.2	0.3	-0.7	1.7	1.1	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.9	1.0	0.7	-0.7	0.2	-0.5	-0.4
Wheeze or whistling in the chest in last year	3.7	6.6	13.9	-1.9	-2.9	2.0	-3.7	-2.0	-2.5
Number of children fathered	0.3	0.4	0.7	0.6	0.8	-0.1	0.8	0.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.6	-0.5	0.2	0.4	0.4	0.5
Age at first live birth	0.7	1.2	3.2	0.1	0.6	-0.9	1.8	1.1	1.2
Pulse wave peak to peak time	0.2	0.3	0.4	0.7	0.4	-0.5	0.5	0.5	0.5
Health satisfaction	3.0	3.9	6.6	-1.9	-2.6	2.5	-2.5	-0.4	-0.8
Shortness of breath walking on level ground	6.0	7.1	15.2	0.5	-1.2	0.4	-3.9	-3.4	-3.8
Qualifications: College or University degree	0.6	1.9	3.1	1.8	1.5	-0.6	1.6	1.1	1.3
Eye problems/disorders: None of the above	0.7	0.8	3.0	0.7	1.0	-1.7	0.5	-0.4	-0.2
Mouth/teeth dental problems: Loose teeth	2.5	3.0	6.4	-2.5	-2.1	2.0	-0.5	1.3	1.0
Emphysema/chronic bronchitis	1.3	1.5	3.4	-0.1	-0.5	-0.5	-1.2	-1.8	-1.8
Medication for pain relief, constipation, heartburn	1.6	2.7	6.7	1.8	1.8	-2.6	1.4	-0.9	-0.5
Neck or shoulder pain in last month	4.7	6.7	13.5	-2.9	-3.7	2.8	-3.0	-0.4	-1.1
Medication: Blood pressure	0.1	0.1	0.4	0.2	0.0	-0.3	-0.6	-0.3	-0.4
Angina (self-reported)	1.6	2.2	5.5	-0.9	-1.5	1.7	-2.3	-0.6	-1.1
Migraine (self-reported)	0.1	0.1	0.4	0.6	0.1	0.2	-0.1	0.3	0.2
Medication: Ibuprofen	2.0	2.3	7.2	-0.2	-1.2	0.7	-2.7	-1.3	-1.8
Medication: Allopurinol	0.9	1.2	2.7	1.6	1.6	-0.6	0.6	0.7	0.8
Medication: Omeprazole	2.6	3.1	6.4	-2.5	-1.5	2.5	0.0	1.5	1.3
Medication: Seretide 50 evohaler	0.1	0.1	0.2	-0.1	0.0	-0.1	-0.2	-0.4	-0.4
Mean time to correctly identify matches	0.6	1.1	2.6	-1.1	0.2	-0.1	1.6	1.0	1.3
Heart disease (mother)	2.4	2.9	6.4	-0.3	0.6	0.9	1.8	2.5	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.0	2.4	5.6	-1.1	-2.4	2.0	-1.8	-0.2	-0.6
Whole body fat mass	1.1	4.8	14.5	-1.8	-0.9	3.8	-0.3	2.5	2.0
Leg fat mass (right)	1.5	5.6	15.8	-1.7	-1.1	4.0	-0.0	2.9	2.4
Arm predicted mass (right)	0.6	3.0	8.9	-0.8	-1.8	3.0	-2.3	0.2	-0.4
Pulse rate, automated reading	5.8	18.6	39.8	-5.0	-4.0	6.3	-0.6	4.3	3.5
Alcohol intake frequency.	0.2	0.5	1.5	-0.7	-0.3	1.2	-0.1	0.9	0.7
Comparative height size at age 10	0.5	2.5	4.7	-1.2	-0.8	1.0	1.6	2.2	2.1
Number of full sisters	3.7	4.4	7.8	-2.8	-2.7	2.8	-0.5	1.5	1.2
Suffer from ‘nerves’	0.3	0.5	0.9	0.5	1.0	-0.8	0.8	0.4	0.5
Overall health rating	3.0	6.4	12.0	-2.3	-2.9	2.6	-3.5	-1.4	-1.9
Chest pain or discomfort	1.6	2.4	5.6	-1.4	-1.9	2.4	-1.6	0.5	-0.0
Had major operations	0.2	0.2	0.5	0.7	0.5	-0.6	0.3	-0.1	-0.1
Age at last live birth	0.5	0.7	1.6	0.4	0.8	-0.6	1.3	0.8	0.9
Family relationship satisfaction	0.1	0.1	0.2	-0.3	0.4	-0.4	0.4	-0.1	0.1
Leg pain on walking	4.0	5.1	10.9	-1.5	-2.6	2.2	-3.3	-1.4	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.4	-0.0	-0.5	-0.5	-0.8	-0.7
Commuting to job workplace: Car/motor vehicle	2.5	2.8	6.1	-1.1	-0.8	1.3	1.3	2.5	2.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.1	0.6	0.6	-1.5	0.3	-0.9	-0.6
Medication: Aspirin	0.2	0.3	0.6	0.0	-0.3	0.8	0.1	0.8	0.7
Supplements: Vitamin C	0.8	0.9	1.6	0.5	0.9	0.0	1.2	1.2	1.3
Knee pain experienced in last month	1.8	2.8	6.6	-2.6	-2.2	2.0	-1.0	0.5	0.1
Hypertension (Self-reported)	1.1	3.1	5.8	2.4	1.8	-2.2	-0.0	-1.7	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	2.2	-0.1	-0.6	-0.3	-1.5	-1.3	-1.5
Illnesses of father: Heart disease	0.6	0.8	1.9	-0.7	-0.9	1.2	-1.4	-0.2	-0.5
Illnesses of siblings: Diabetes	2.6	3.1	8.5	-2.9	-2.4	1.9	-0.7	0.6	0.3
Smoking status: Previous	0.5	0.8	2.6	-1.6	-0.5	-0.3	1.1	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.2	-1.0	-1.1	0.6	-0.9	0.2	-0.2
Whole body fat-free mass	0.6	3.3	9.4	-1.0	-2.1	3.1	-2.1	0.4	-0.2
Leg fat-free mass (right)	0.7	3.6	8.7	-0.9	-2.0	3.0	-2.7	-0.2	-0.8
Arm fat percentage (left)	0.7	2.8	9.0	-1.4	-0.2	3.0	-0.3	1.9	1.5
Average weekly red wine intake	0.6	0.8	1.6	-0.3	-0.4	1.3	0.4	1.2	1.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	-0.3	0.4	-0.0	0.2	0.3
Mood swings	2.0	3.5	5.8	-2.4	-1.9	2.4	0.1	1.9	1.6
Loneliness, isolation	1.6	2.2	5.3	1.7	1.4	-2.3	0.6	-1.3	-0.9
Long-standing illness, disability or infirmity	2.1	3.3	4.8	-1.8	-2.2	1.1	-2.1	-1.6	-1.8
Ever had bowel cancer screening	3.2	3.8	9.4	0.8	1.8	-1.2	3.1	1.8	2.2
Diabetes diagnosed by doctor	2.0	3.3	8.0	-2.2	-2.2	2.8	-0.8	1.1	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.5	-0.5	-0.2	-0.5	-0.4	-0.7	-0.7
Friendships satisfaction	0.5	0.6	1.1	-0.9	0.2	0.5	0.7	1.0	1.0
Qualifications: nursing, teaching	0.7	1.1	2.7	0.9	0.8	-1.1	1.6	0.6	0.8
Commuting to job workplace: Walk	0.7	0.7	1.5	-0.4	-0.4	-0.1	-1.1	-1.1	-1.2
Eye problems/disorders: Cataract	0.7	0.8	3.2	-0.7	-0.9	1.8	-0.6	0.3	0.2
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.5	1.3	1.6	-1.3	1.2	0.5	0.6
Medication for cholesterol	1.5	2.3	5.2	-1.0	-0.3	1.5	1.2	2.3	2.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	5.3	6.3	11.6	0.9	2.2	0.2	3.2	3.2	3.4
Back pain experienced in last month	4.5	6.5	10.3	-2.9	-3.2	1.2	-2.9	-2.1	-2.5
Mineral and other dietary supplements	1.7	2.3	3.8	1.7	0.9	-1.5	-1.0	-2.0	-1.8
Breast cancer (self-reported)	0.2	0.2	0.3	-0.5	-0.2	0.6	0.1	0.5	0.4
Asthma (self-reported)	3.4	6.9	15.6	-1.5	-2.8	1.5	-3.9	-2.2	-2.8
Osteoporosis (self-reported)	0.6	0.7	1.5	-1.0	0.3	-1.2	1.2	0.2	0.4
Osteoarthritis (self-reported)	1.5	1.9	4.1	-1.7	-1.2	2.0	0.4	1.3	1.1
Medication: Aspirin	0.4	0.5	1.0	-0.4	-0.4	0.9	0.3	1.0	1.0
Medication: Gliclazide	0.1	0.1	0.4	0.2	-0.1	0.3	-0.7	-0.2	-0.3
Illnesses of father: None of the above (group 1)	1.8	2.2	4.5	-1.1	-0.1	1.2	1.4	2.0	2.1
Smoking status: Current	3.7	5.9	15.8	-0.1	-2.0	1.0	-4.0	-2.5	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.2	13.1	25.6	3.1	4.1	-3.0	5.1	2.5	3.3
Whole body water mass	0.6	3.3	9.5	-1.0	-2.1	3.1	-2.1	0.4	-0.2
Leg predicted mass (right)	0.7	3.7	8.9	-1.0	-2.0	3.0	-2.7	-0.2	-0.8
Arm fat mass (left)	1.0	4.3	14.7	-1.9	-1.4	3.8	-1.2	1.7	1.1
Number of self-reported non-cancer illnesses	1.3	2.3	4.6	-1.4	-2.1	1.3	-1.8	-0.9	-1.2
Average weekly champagne plus white wine intake	0.3	0.4	1.0	0.6	0.8	-1.0	0.4	-0.4	-0.2
Miserableness	0.3	0.6	1.1	-0.4	-0.5	0.3	-1.1	-0.9	-1.0
Guilty feelings	0.4	0.6	1.3	-0.1	0.0	0.2	1.1	1.1	1.1
Wears glasses or contact lenses	0.5	0.6	2.1	-0.9	-0.7	1.5	-0.4	0.1	0.1
Ever taken oral contraceptive pill	2.0	2.2	3.7	-1.9	-1.3	1.8	0.0	1.6	1.4
Hearing aid user	0.5	0.6	1.9	1.3	1.4	-0.4	0.1	-0.2	-0.1
Mother’s age at death	0.9	1.2	2.7	1.3	1.6	-1.4	0.7	-0.5	-0.2
Financial situation satisfaction	0.1	0.1	0.4	-0.0	-0.2	0.0	-0.7	-0.1	-0.2
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.8	-0.3	0.5	0.3	0.7	0.6
Commuting to job workplace: Public transport	2.5	2.9	5.1	1.8	1.3	-1.7	-0.9	-2.3	-2.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.3	-0.9	-1.2	0.8	-0.9	-0.3	-0.5
Medication: Blood pressure	2.6	5.0	10.2	2.9	2.5	-3.2	0.6	-1.8	-1.2
Pain type(s) experienced in last month: Hip pain	0.9	1.1	1.6	-1.2	-1.3	-0.1	-1.1	-1.0	-1.1
Supplements: Fish oil (including cod liver oil)	2.3	3.0	7.6	0.5	1.5	-0.6	2.8	1.8	2.1
High cholesterol (Self-reported)	0.1	0.2	0.7	0.8	0.6	-0.5	0.1	-0.3	-0.2
Medication: Bendroflumethiazide	1.9	2.9	7.3	1.7	1.5	-2.7	0.4	-1.8	-1.3
Medication: Paracetamol	2.7	4.2	8.6	-2.9	-2.5	2.7	-0.8	1.3	0.8
Medication: Lisinopril	0.6	0.7	1.3	1.1	0.9	-1.1	0.9	0.3	0.4
Medication: Atorvastatin	0.5	0.6	0.9	0.3	0.9	0.3	0.9	0.9	0.9
Illnesses of father: High blood pressure	0.8	1.0	2.8	1.7	0.7	-1.2	-0.2	-0.8	-0.7
Alcohol drinker status: Never	1.0	1.2	2.1	-1.2	-0.3	0.6	1.1	1.4	1.4
Ever smoked	0.7	1.2	2.4	-1.4	-1.6	0.1	-0.9	-1.0	-1.0
Basal metabolic rate	0.6	3.5	11.5	-1.2	-2.0	3.4	-1.8	0.9	0.3
Leg fat percentage (left)	1.9	6.7	13.5	-1.3	-0.1	3.6	1.0	3.7	3.3
Arm fat-free mass (left)	0.8	4.1	13.2	-1.2	-2.2	3.6	-1.9	1.1	0.5
Number of operations (self-reported)	1.3	2.0	2.9	-1.5	-1.1	1.7	0.6	1.7	1.5
Average weekly beer plus cider intake	4.2	6.1	10.4	-2.6	-3.2	2.8	-3.1	-0.6	-1.3
Irritability	4.1	6.9	15.1	-3.5	-3.9	3.2	-1.9	0.7	0.2
Risk taking	0.2	0.3	0.5	0.4	0.3	-0.2	0.6	0.7	0.7
Ever had prostate specific antigen (PSA) test	2.7	3.2	5.1	1.8	2.2	-1.5	2.3	1.1	1.5
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.1	-0.0	-0.8	-0.4	-1.0	-0.8
Age started oral contraceptive pill	0.2	0.3	0.8	-0.9	-0.8	0.5	-0.2	-0.1	-0.1
Diastolic blood pressure, automated reading	2.1	6.6	14.2	1.2	0.4	-1.3	-2.8	-3.8	-3.8
Ever depressed for a whole week	1.5	1.8	2.6	-1.4	-0.7	1.4	1.0	1.6	1.6
Unable to work because of sickness or disability	0.7	1.0	1.7	-0.5	-1.1	0.1	-1.3	-1.1	-1.2
Commuting to job workplace: Cycle	2.3	2.7	4.1	1.8	1.4	-1.8	-0.8	-2.0	-1.8
Myopia	2.1	3.0	6.7	-0.1	0.5	-0.1	2.6	2.2	2.4
Vascular/heart problems diagnosed by doctor	1.1	3.0	5.5	-2.4	-1.5	2.1	0.5	1.8	1.5
Cholesterol lowering medication	0.5	0.7	1.1	1.0	0.8	-1.0	-0.1	-0.9	-0.8
Medication: Omeprazole (e.g. Zanprol)	2.3	2.7	5.6	-2.4	-1.6	2.3	-0.1	1.3	1.1
Pain experienced in last month	2.3	3.8	9.0	3.0	2.3	-2.5	0.6	-1.3	-0.8
Supplements: Calcium	2.0	2.2	4.6	-1.8	-2.1	2.0	-0.5	0.9	0.7
Basal cell carcinoma (self-reported)	0.9	1.1	1.5	-1.2	-0.3	0.6	1.2	1.1	1.2
Heart attack/myocardial infarction (self-reported)	1.8	2.4	5.0	1.5	0.0	-0.0	-2.2	-1.8	-1.9
Deep venous thrombosis (DVT) (self-reported)	1.5	1.9	3.6	1.9	1.6	-1.5	1.4	0.6	0.9
Heart disease (siblings)	1.4	1.7	3.6	-1.2	-1.9	1.9	-1.2	0.3	-0.0
Alcohol drinker status: Previous	0.1	0.2	0.8	0.2	-0.0	0.9	-0.2	0.2	0.1
Pack years of smoking	2.7	4.0	9.8	-0.7	-2.2	2.5	-3.1	-0.7	-1.3
Impedance of whole body	0.7	3.4	8.4	0.1	1.5	-1.9	2.9	1.6	1.9
Leg fat mass (left)	1.4	5.6	16.4	-1.8	-1.1	4.0	-0.2	2.8	2.3
Arm predicted mass (left)	0.7	3.7	12.4	-1.1	-2.0	3.5	-1.7	1.1	0.5