[Hub]/) : Traits : Peak expiratory flow (PEF) :

chr1:203,793,652-206,329,620

Best TWAS P=5.07e-23 · Best GWAS P=1.27e-28 conditioned to 1.44e-06

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PM20D1 0.27 0.41 enet 15 0.41 7.8e-54 -7.1 -7.1 1.1e-12 0.38 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex SLC26A9 0.13 0.16 lasso 3 0.16 3.1e-19 -7.1 -7.8 7.4e-15 0.40 1.00 0.00 FALSE
3 GTEx Adipose Subcutaneous NUCKS1 0.11 0.10 lasso 3 0.08 9.4e-07 -6.3 6.4 1.4e-10 -0.38 0.98 0.01 FALSE
4 GTEx Adrenal Gland NUCKS1 0.17 0.00 enet 11 0.02 6.7e-02 -6.8 5.8 5.3e-09 -0.30 0.09 0.16 FALSE
5 GTEx Artery Aorta NUCKS1 0.14 0.11 lasso 3 0.08 3.7e-05 -6.8 6.3 2.1e-10 -0.37 0.77 0.11 FALSE
6 GTEx Artery Coronary RAB7L1 0.47 0.10 enet 55 0.19 5.5e-07 4.3 -6.0 2.1e-09 0.22 0.52 0.03 FALSE
7 GTEx Artery Tibial NUCKS1 0.13 0.03 lasso 2 0.01 4.0e-02 -7.6 7.9 3.9e-15 -0.39 0.21 0.41 FALSE
8 GTEx Brain Caudate basal ganglia NUCKS1 0.25 0.24 lasso 3 0.25 8.1e-08 5.2 -5.2 2.3e-07 0.30 0.42 0.05 FALSE
9 GTEx Brain Cerebellum NUCKS1 0.22 0.13 lasso 3 0.08 2.0e-03 -7.6 7.5 8.0e-14 -0.40 0.26 0.15 FALSE
10 GTEx Brain Cerebellum SLC41A1 0.27 0.09 lasso 4 0.08 2.1e-03 -6.7 -6.7 1.9e-11 0.33 0.11 0.05 FALSE
11 GTEx Brain Putamen basal ganglia NUCKS1 0.40 0.26 lasso 4 0.27 3.2e-07 -6.3 6.3 2.5e-10 -0.38 0.34 0.07 FALSE
12 GTEx Breast Mammary Tissue NUCKS1 0.15 0.05 lasso 4 0.09 2.5e-05 -6.3 6.3 3.0e-10 -0.38 0.82 0.02 FALSE
13 GTEx Cells Transformed fibroblasts RAB7L1 0.30 0.23 enet 19 0.36 8.6e-28 3.4 -5.8 7.3e-09 0.37 1.00 0.00 FALSE
14 GTEx Esophagus Mucosa NUCKS1 0.12 0.11 enet 6 0.06 7.2e-05 5.2 5.9 3.0e-09 -0.34 0.77 0.19 FALSE
15 GTEx Esophagus Mucosa RAB7L1 0.26 0.11 enet 34 0.18 4.5e-12 5.2 -6.2 8.0e-10 0.33 1.00 0.00 TRUE
16 GTEx Esophagus Mucosa SLC41A1 0.17 0.09 enet 25 0.12 1.1e-08 -7.1 -6.2 4.5e-10 0.32 0.68 0.26 FALSE
17 GTEx Esophagus Muscularis NUCKS1 0.21 0.22 lasso 5 0.20 3.6e-12 -6.7 6.8 1.1e-11 -0.38 1.00 0.00 FALSE
18 GTEx Esophagus Muscularis MDM4 0.14 0.05 lasso 4 0.05 8.6e-04 -5.7 -5.6 1.8e-08 0.02 0.01 0.98 TRUE
19 GTEx Heart Atrial Appendage NUCKS1 0.12 0.14 enet 4 0.08 1.7e-04 5.2 5.8 6.8e-09 -0.32 0.44 0.05 FALSE
20 GTEx Heart Atrial Appendage RAB7L1 0.20 0.17 enet 12 0.14 4.9e-07 5.2 -5.7 1.4e-08 0.35 0.97 0.01 FALSE
21 GTEx Heart Left Ventricle NUCKS1 0.10 0.04 lasso 3 0.05 1.4e-03 -6.8 7.0 3.6e-12 -0.39 0.20 0.27 FALSE
22 GTEx Lung NUCKS1 0.09 0.07 lasso 3 0.04 2.6e-04 -6.3 6.2 4.7e-10 -0.38 0.76 0.19 FALSE
23 GTEx Nerve Tibial NUCKS1 0.25 0.21 enet 16 0.22 7.3e-16 -6.4 6.9 5.0e-12 -0.40 1.00 0.00 FALSE
24 GTEx Nerve Tibial SLC41A1 0.12 0.02 lasso 4 0.05 2.5e-04 -7.1 -6.4 1.4e-10 0.35 0.74 0.01 FALSE
25 GTEx Pancreas NUCKS1 0.16 0.00 lasso 4 0.00 4.5e-01 5.2 8.3 1.1e-16 -0.54 0.09 0.31 FALSE
26 GTEx Pancreas SLC41A1 0.24 0.21 lasso 5 0.19 1.4e-08 -7.1 -7.2 8.1e-13 0.38 0.92 0.02 FALSE
27 GTEx Pituitary NUCKS1 0.26 0.19 lasso 2 0.20 7.6e-06 -6.7 6.7 2.2e-11 -0.36 0.13 0.61 FALSE
28 GTEx Prostate NUCKS1 0.38 0.23 lasso 8 0.32 7.5e-09 6.2 -6.7 2.2e-11 0.40 0.34 0.14 FALSE
29 GTEx Skin Not Sun Exposed Suprapubic NUCKS1 0.20 0.14 lasso 4 0.13 2.0e-07 -6.3 6.6 3.9e-11 -0.38 0.99 0.00 FALSE
30 GTEx Skin Sun Exposed Lower leg NUCKS1 0.20 0.26 lasso 5 0.26 1.5e-21 -6.3 6.5 7.7e-11 -0.39 1.00 0.00 FALSE
31 GTEx Skin Sun Exposed Lower leg SLC45A3 0.08 0.00 lasso 5 0.00 3.6e-01 5.2 5.2 1.8e-07 -0.31 0.13 0.04 FALSE
32 GTEx Spleen NUCKS1 0.24 0.04 enet 44 0.10 1.6e-03 -7.1 5.8 5.6e-09 -0.33 0.08 0.30 FALSE
33 GTEx Stomach NUCKS1 0.21 0.11 lasso 8 0.15 1.1e-07 -6.7 7.1 1.2e-12 -0.40 0.92 0.03 FALSE
34 GTEx Testis NUCKS1 0.16 0.16 enet 15 0.16 1.3e-07 -6.8 7.0 2.3e-12 -0.40 0.95 0.01 FALSE
35 GTEx Thyroid NUCKS1 0.26 0.16 lasso 6 0.19 1.8e-14 -6.5 6.9 4.9e-12 -0.38 1.00 0.00 FALSE
36 GTEx Thyroid SLC41A1 0.06 0.00 enet 10 0.02 1.5e-02 -7.1 -6.6 5.2e-11 0.33 0.05 0.51 FALSE
37 METSIM Adipose NUCKS1 0.05 0.02 lasso 6 0.01 4.3e-03 -6.8 6.7 1.8e-11 -0.38 0.62 0.04 FALSE
38 METSIM Adipose PM20D1 0.25 0.30 bslmm 377 0.31 8.4e-47 -7.1 7.2 5.5e-13 -0.39 1.00 0.00 FALSE
39 METSIM Adipose SLC41A1 0.07 0.08 lasso 7 0.08 1.9e-11 6.2 -6.7 3.0e-11 0.38 1.00 0.00 FALSE
40 YFS Blood NUCKS1 0.15 0.24 lasso 4 0.25 1.4e-80 -6.3 6.5 1.2e-10 -0.38 1.00 0.00 FALSE
41 YFS Blood RAB7L1 0.06 0.07 lasso 6 0.06 1.1e-19 5.2 -5.9 4.0e-09 0.33 1.00 0.00 FALSE
42 YFS Blood SLC41A1 0.06 0.05 enet 15 0.05 2.6e-17 -7.6 -7.1 9.1e-13 0.36 1.00 0.00 FALSE
43 The Cancer Genome Atlas Bladder Urothelial Carcinoma PM20D1 0.22 0.26 lasso 5 0.26 1.7e-22 -7.6 7.7 1.1e-14 -0.41 0.02 0.98 FALSE
44 The Cancer Genome Atlas Breast Invasive Carcinoma PM20D1 0.24 0.37 lasso 5 0.39 4.9e-85 -7.1 7.6 3.5e-14 -0.40 0.22 0.78 FALSE
45 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma PM20D1 0.18 0.19 blup 47 0.18 1.9e-09 -7.1 7.9 2.1e-15 -0.43 0.06 0.94 FALSE
46 The Cancer Genome Atlas Colon Adenocarcinoma PM20D1 0.26 0.13 enet 14 0.16 9.7e-10 6.2 8.2 2.5e-16 -0.40 0.21 0.79 FALSE
47 The Cancer Genome Atlas Glioblastoma Multiforme PM20D1 0.29 0.06 blup 47 0.18 3.9e-06 -7.9 7.5 9.0e-14 -0.35 0.00 0.98 FALSE
48 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma PM20D1 0.19 0.25 lasso 5 0.25 3.0e-28 -7.1 7.4 1.8e-13 -0.40 0.05 0.95 FALSE
49 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma RAB7L1 0.09 0.13 lasso 6 0.13 3.6e-14 4.4 -5.9 4.6e-09 0.34 0.58 0.42 FALSE
50 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma SLC45A3 0.08 0.00 blup 80 0.03 5.5e-04 3.4 -5.3 1.4e-07 0.24 0.03 0.43 FALSE
51 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PM20D1 0.29 0.35 enet 18 0.35 5.1e-41 -7.1 7.4 1.6e-13 -0.38 0.22 0.78 FALSE
52 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma RAB7L1 0.09 0.08 enet 11 0.08 1.7e-09 5.2 -5.9 3.1e-09 0.34 0.62 0.38 FALSE
53 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma PM20D1 0.19 0.19 enet 4 0.19 4.5e-11 -7.1 7.4 1.0e-13 -0.40 0.03 0.97 FALSE
54 The Cancer Genome Atlas Brain Lower Grade Glioma PM20D1 0.41 0.43 enet 20 0.44 9.2e-55 -7.1 7.6 2.8e-14 -0.39 0.22 0.78 FALSE
55 The Cancer Genome Atlas Brain Lower Grade Glioma RAB7L1 0.09 0.08 lasso 2 0.07 1.1e-08 5.2 -5.2 1.8e-07 0.30 0.99 0.01 FALSE
56 The Cancer Genome Atlas Lung Adenocarcinoma PM20D1 0.31 0.39 enet 16 0.41 5.1e-52 -7.1 7.9 2.7e-15 -0.40 0.05 0.95 FALSE
57 The Cancer Genome Atlas Lung Adenocarcinoma RAB7L1 0.02 0.02 enet 5 0.03 4.6e-04 4.4 -5.8 7.7e-09 0.35 0.02 0.53 FALSE
58 The Cancer Genome Atlas Lung Squamous Cell Carcinoma PM20D1 0.26 0.34 lasso 3 0.34 1.9e-40 -7.1 7.2 4.0e-13 -0.40 0.22 0.78 FALSE
59 The Cancer Genome Atlas Lung Squamous Cell Carcinoma RAB7L1 0.06 0.05 enet 6 0.06 2.6e-07 4.3 -6.7 2.9e-11 0.37 0.28 0.70 FALSE
60 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma PM20D1 0.12 0.13 blup 47 0.12 9.1e-09 -7.1 7.5 6.5e-14 -0.38 0.10 0.90 FALSE
61 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma RAB7L1 0.06 0.06 blup 46 0.06 5.2e-05 -6.8 -6.9 5.3e-12 0.41 0.01 0.98 FALSE
62 The Cancer Genome Atlas Pancreatic Adenocarcinoma PM20D1 0.32 0.34 lasso 2 0.34 9.7e-15 -7.6 7.5 7.3e-14 -0.39 0.02 0.98 FALSE
63 The Cancer Genome Atlas Pancreatic Adenocarcinoma RAB7L1 0.09 0.04 blup 46 0.04 1.2e-02 5.2 -5.9 4.3e-09 0.35 0.06 0.67 FALSE
64 The Cancer Genome Atlas Pancreatic Adenocarcinoma SLC26A9 0.15 0.06 lasso 3 0.05 5.2e-03 9.9 9.9 5.1e-23 -0.52 0.08 0.47 TRUE
65 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PM20D1 0.34 0.13 enet 20 0.21 9.7e-09 4.8 6.1 1.3e-09 -0.29 0.18 0.82 FALSE
66 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma RAB7L1 0.17 0.13 lasso 2 0.11 4.4e-05 5.2 -5.2 2.1e-07 0.29 0.12 0.48 FALSE
67 The Cancer Genome Atlas Prostate Adenocarcinoma NUCKS1 0.04 0.05 lasso 2 0.03 1.5e-04 -6.8 7.0 3.4e-12 -0.42 0.10 0.82 FALSE
68 The Cancer Genome Atlas Prostate Adenocarcinoma PM20D1 0.16 0.14 enet 15 0.16 5.6e-16 -7.1 8.0 9.6e-16 -0.44 0.23 0.77 FALSE
69 The Cancer Genome Atlas Prostate Adenocarcinoma RAB7L1 0.12 0.12 lasso 2 0.12 3.8e-12 5.2 -5.2 1.6e-07 0.30 1.00 0.00 FALSE
70 The Cancer Genome Atlas Rectum Adenocarcinoma PM20D1 0.17 0.02 blup 47 0.01 2.2e-01 -7.6 7.1 1.4e-12 -0.37 0.01 0.43 FALSE
71 The Cancer Genome Atlas Soft Tissue Sarcoma PM20D1 0.23 0.24 lasso 4 0.24 1.2e-14 -7.1 7.1 1.2e-12 -0.38 0.06 0.94 FALSE
72 The Cancer Genome Atlas Skin Cutaneous Melanoma PM20D1 0.17 0.11 lasso 3 0.07 5.0e-03 -7.1 7.3 2.8e-13 -0.39 0.02 0.36 FALSE
73 The Cancer Genome Atlas Stomach Adenocarcinoma PM20D1 0.09 0.11 enet 6 0.10 1.3e-07 6.2 6.7 2.5e-11 -0.39 0.34 0.65 FALSE
74 The Cancer Genome Atlas Stomach Adenocarcinoma RAB7L1 0.07 0.04 blup 46 0.07 1.2e-05 -7.6 -5.9 3.5e-09 0.35 0.00 0.99 FALSE
75 The Cancer Genome Atlas Testicular Germ Cell Tumors PM20D1 0.42 0.34 lasso 3 0.34 6.9e-13 -7.1 7.2 4.5e-13 -0.36 0.14 0.86 FALSE
76 The Cancer Genome Atlas Testicular Germ Cell Tumors SLC41A1 0.13 0.03 blup 55 0.03 2.6e-02 -6.8 6.5 6.7e-11 -0.32 0.03 0.67 FALSE
77 The Cancer Genome Atlas Thyroid Carcinoma NUCKS1 0.07 0.07 blup 59 0.07 1.3e-07 -6.5 6.4 1.6e-10 -0.37 0.03 0.97 FALSE
78 The Cancer Genome Atlas Thyroid Carcinoma PM20D1 0.26 0.40 lasso 4 0.41 2.0e-42 -7.1 7.3 3.5e-13 -0.39 0.09 0.91 FALSE
79 The Cancer Genome Atlas Thyroid Carcinoma RAB7L1 0.13 0.17 enet 15 0.21 3.6e-20 5.2 -6.3 2.9e-10 0.38 0.10 0.90 FALSE
80 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma NUCKS1 0.11 0.02 blup 58 0.09 1.9e-03 4.3 5.9 2.9e-09 -0.36 0.03 0.46 FALSE
81 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma PM20D1 0.19 0.09 lasso 4 0.12 4.2e-04 -7.6 8.0 1.1e-15 -0.41 0.01 0.82 FALSE