Best TWAS P=2.43e-17 · Best GWAS P=9.49e-17 conditioned to 0.0425
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USMG5 | 0.03 | 0.01 | bslmm | 352 | 0.00 | 7.5e-02 | -3.0 | 5.2 | 1.7e-07 | -0.51 | 0.17 | 0.38 | FALSE |
| 2 | GTEx | Cells Transformed fibroblasts | SUFU | 0.07 | 0.04 | lasso | 3 | 0.04 | 3.5e-04 | -7.7 | -7.5 | 5.2e-14 | 0.83 | 0.19 | 0.58 | FALSE |
| 3 | GTEx | Testis | NT5C2 | 0.20 | 0.03 | lasso | 8 | 0.08 | 2.8e-04 | -7.7 | -8.5 | 2.4e-17 | 0.86 | 0.04 | 0.91 | TRUE |
| 4 | GTEx | Testis | CYP17A1-AS1 | 0.14 | 0.08 | enet | 5 | 0.10 | 2.3e-05 | -7.6 | 7.7 | 1.3e-14 | -0.97 | 0.05 | 0.94 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | CNNM2 | 0.11 | 0.08 | lasso | 3 | 0.07 | 2.2e-09 | -7.7 | -7.8 | 7.9e-15 | 0.99 | 0.02 | 0.98 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | USMG5 | 0.04 | 0.03 | lasso | 9 | 0.03 | 1.6e-04 | -3.0 | 5.5 | 2.9e-08 | -0.64 | 0.04 | 0.94 | FALSE |
| 7 | YFS | Blood | NT5C2 | 0.13 | 0.10 | bslmm | 382 | 0.11 | 7.3e-35 | -8.0 | -8.2 | 3.5e-16 | 0.94 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NT5C2 | 0.14 | 0.13 | lasso | 5 | 0.12 | 4.4e-12 | 4.7 | -5.4 | 7.3e-08 | 0.31 | 1.00 | 0.00 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | AS3MT | 0.05 | 0.02 | blup | 62 | 0.03 | 2.1e-03 | 3.5 | -7.2 | 7.4e-13 | 0.72 | 0.02 | 0.57 | FALSE |