[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr4:85,698,680-89,692,911

Best TWAS P=4.14e-14 · Best GWAS P=8.78e-14 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous RP13-514E23.2 0.09 0.03 enet 11 0.04 2.0e-04 5.2 5.2 2.4e-07 0.02 0.02 0.94 FALSE
2 GTEx Artery Aorta ARHGAP24 0.24 0.13 enet 8 0.14 2.2e-08 5.2 5.9 4.6e-09 0.03 0.01 0.99 FALSE
3 GTEx Artery Aorta RP13-514E23.2 0.26 0.09 lasso 6 0.10 2.2e-06 5.6 5.8 7.4e-09 0.04 0.01 0.99 FALSE
4 GTEx Artery Tibial ARHGAP24 0.26 0.19 enet 14 0.21 2.7e-16 5.6 5.5 5.0e-08 0.03 0.00 1.00 FALSE
5 GTEx Artery Tibial RP13-514E23.2 0.22 0.16 enet 10 0.18 1.2e-13 5.6 5.9 4.4e-09 0.03 0.00 1.00 TRUE
6 GTEx Nerve Tibial SPP1 0.15 0.08 lasso 3 0.08 2.4e-06 7.5 7.6 4.1e-14 0.99 0.00 1.00 TRUE
7 METSIM Adipose HSD17B13 0.20 0.10 bslmm 416 0.12 7.3e-18 -4.5 5.3 1.5e-07 -0.08 0.90 0.10 TRUE
8 ROSMAP Brain Pre-frontal Cortex PKD2 0.11 0.09 lasso 13 0.11 3.3e-14 3.9 5.5 3.8e-08 0.39 1.00 0.00 FALSE
9 The Cancer Genome Atlas Breast Invasive Carcinoma IBSP 0.05 0.05 lasso 6 0.07 1.2e-13 4.1 -5.8 4.8e-09 -0.12 1.00 0.00 TRUE
10 The Cancer Genome Atlas Breast Invasive Carcinoma SPP1 0.04 0.00 enet 11 0.01 3.3e-03 4.6 5.2 2.2e-07 0.72 0.00 0.96 FALSE
11 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MEPE 0.08 0.01 blup 87 0.05 2.3e-06 5.1 5.5 3.5e-08 0.27 0.44 0.04 FALSE
12 The Cancer Genome Atlas Brain Lower Grade Glioma IBSP 0.06 0.01 blup 78 0.03 8.2e-05 5.5 -5.6 2.2e-08 -0.25 0.18 0.08 FALSE
13 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IBSP 0.03 0.01 blup 78 0.03 2.8e-04 -5.4 -6.5 1.1e-10 -0.35 0.09 0.09 FALSE
14 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma IBSP 0.16 0.05 blup 76 0.08 3.6e-06 -5.4 -6.5 9.2e-11 -0.26 0.93 0.03 FALSE