[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr4:85,698,680-89,692,911

Best TWAS P=4.14e-14 · Best GWAS P=8.78e-14 conditioned to 1

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Nerve Tibial	SPP1	0.15	0.08	lasso	3	0.08	2.4e-06	7.5	7.6	4.1e-14	0.99	0.00	1.00	TRUE
5	GTEx	Artery Tibial	RP13-514E23.2	0.22	0.16	enet	10	0.18	1.2e-13	5.6	5.9	4.4e-09	0.03	0.00	1.00	TRUE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	IBSP	0.05	0.05	lasso	6	0.07	1.2e-13	4.1	-5.8	4.8e-09	-0.12	1.00	0.00	TRUE
7	METSIM	Adipose	HSD17B13	0.20	0.10	bslmm	416	0.12	7.3e-18	-4.5	5.3	1.5e-07	-0.08	0.90	0.10	TRUE
14	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IBSP	0.16	0.05	blup	76	0.08	3.6e-06	-5.4	-6.5	9.2e-11	-0.26	0.93	0.03	FALSE
13	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IBSP	0.03	0.01	blup	78	0.03	2.8e-04	-5.4	-6.5	1.1e-10	-0.35	0.09	0.09	FALSE
2	GTEx	Artery Aorta	ARHGAP24	0.24	0.13	enet	8	0.14	2.2e-08	5.2	5.9	4.6e-09	0.03	0.01	0.99	FALSE
3	GTEx	Artery Aorta	RP13-514E23.2	0.26	0.09	lasso	6	0.10	2.2e-06	5.6	5.8	7.4e-09	0.04	0.01	0.99	FALSE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	IBSP	0.06	0.01	blup	78	0.03	8.2e-05	5.5	-5.6	2.2e-08	-0.25	0.18	0.08	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MEPE	0.08	0.01	blup	87	0.05	2.3e-06	5.1	5.5	3.5e-08	0.27	0.44	0.04	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	PKD2	0.11	0.09	lasso	13	0.11	3.3e-14	3.9	5.5	3.8e-08	0.39	1.00	0.00	FALSE
4	GTEx	Artery Tibial	ARHGAP24	0.26	0.19	enet	14	0.21	2.7e-16	5.6	5.5	5.0e-08	0.03	0.00	1.00	FALSE
10	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPP1	0.04	0.00	enet	11	0.01	3.3e-03	4.6	5.2	2.2e-07	0.72	0.00	0.96	FALSE
1	GTEx	Adipose Subcutaneous	RP13-514E23.2	0.09	0.03	enet	11	0.04	2.0e-04	5.2	5.2	2.4e-07	0.02	0.02	0.94	FALSE