Hub : Genes

MEPE

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1540	0.0390	8.7e-07	0.050	0.053	0.066	0.069	0.065	8.9e-07	4.7e-07	1.8e-08	9.7e-09	2.1e-08
2	ROSMAP	Brain Pre-frontal Cortex	0.1712	0.0475	5.7e-06	0.116	0.066	0.111	0.116	0.114	9.5e-15	7.0e-09	3.9e-14	1.1e-14	1.6e-14
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0800	0.0307	2.3e-05	0.010	0.050	0.040	NA	0.031	2.2e-02	2.3e-06	2.2e-05	NA	1.8e-04
4	TCGA	Lung Squamous Cell Carcinoma	0.0866	0.0455	3.9e-03	0.035	0.022	0.043	NA	0.026	7.4e-05	1.3e-03	1.0e-05	NA	5.0e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	1.1	1.7	4.1	-1.4	-2.0	0.8	-0.3
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.4	0.6	0.2	-0.5
Depressed Affect (Nagel 2018)	0.0	0.1	0.1	0.3	0.3	-0.4	-0.2
Depression (Nagel 2018)	0.1	0.2	0.6	-0.8	-0.4	0.2	0.2
Intelligence (Savage-Jansen 2018)	0.3	1.1	3.1	1.0	0.3	0.1	1.8
Neuroticism (Nagel 2018)	0.2	0.5	1.0	-0.7	-0.4	-0.5	-1.0
Schizophrenia (2018)	1.0	2.1	5.4	1.6	2.3	-0.3	-0.2
Schizophrenia vs Biploar Disorder	0.8	1.1	3.0	1.0	1.7	-0.5	0.5
Worry (Nagel 2018)	0.6	1.3	2.7	-1.6	-1.2	-0.1	-1.1
Alzheimer’s Disease (in mother)	1.7	2.0	2.7	-1.4	-1.6	1.5	-1.0
Alzheimer’s Disease (in father)	2.2	2.4	5.8	2.4	1.7	0.0	0.8
Alzheimer’s Disease (including proxy)	0.5	0.7	2.7	0.3	-0.1	1.7	0.2
Crohns Disease (2017)	1.6	3.4	4.9	1.6	1.4	-2.1	-2.2
Irritable Bowel Disease (IBD)	1.8	4.3	7.2	1.4	2.2	-2.7	-1.8
Ulcerative Colitis (UC)	1.9	3.6	6.1	0.8	2.5	-2.4	-1.3
Major Depression (MDD)	1.3	1.6	6.0	0.8	-0.1	-2.4	-0.0
Reaction Time	0.3	0.6	1.9	-0.7	-1.4	-0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.6	0.0	-0.6	0.8	0.2
Breast Cancer	0.9	2.2	4.0	0.6	1.9	0.9	-2.0
Ovarian Cancer	1.0	1.3	3.4	-1.9	-0.8	1.1	-0.1
Prostate Cancer	0.7	1.0	1.5	-1.0	-1.2	-0.8	0.9
Age at First Birth	1.3	1.9	5.3	0.7	1.0	-0.8	2.3
Bipolar Disorder (2011)	0.2	0.1	0.4	-0.4	-0.0	-0.1	-0.7
Body Mass Index (BMI) (2010)	1.6	2.1	4.6	-1.7	-2.1	0.6	-0.8
Coronary Artery Disease (CAD)	2.2	2.7	7.8	0.3	0.1	-2.8	-1.7
Crohns Disease (2012)	1.1	1.7	3.4	1.0	0.8	-1.3	-1.9
Mean Putamen Volume	0.3	0.3	0.7	0.1	0.4	0.9	-0.6
Fasting Glucose	0.2	0.2	0.4	-0.4	0.3	0.5	-0.6
HbA1C	2.4	2.6	8.5	1.4	2.9	-0.2	0.2
HDL Cholesterol	1.9	3.2	4.8	2.2	2.0	0.7	1.8
LDL Cholesterol	0.8	1.2	3.2	0.7	1.8	-0.1	-1.1
Lupus	1.5	2.3	5.1	-1.6	-2.3	-0.9	0.9
Neuroticism (2016)	1.6	2.3	3.9	1.8	1.3	-2.0	-0.7
Primary Biliary Cirrhosis	1.3	1.8	4.9	-1.0	1.2	2.2	-0.3
Rheumatoid Arthritis	0.8	1.1	3.0	0.6	1.7	0.6	0.8
Schizophrenia (2014)	0.5	1.0	3.0	1.0	1.7	0.2	0.2
Triglycerides	0.4	0.7	2.1	0.1	-0.0	-1.5	-0.8
Type 2 Diabetes (T2D) (2012)	2.0	2.3	4.8	1.4	1.6	-0.3	-2.2
Ulcerative Colitis	0.8	1.1	2.9	0.5	1.7	-1.0	-0.7
Blood Eosinophil Count	0.3	2.4	8.4	-0.3	1.0	-2.9	-0.5
Blood Platelet Count	0.2	2.2	5.2	-2.3	-1.4	-1.0	0.6
Blood Red Count	0.2	2.0	6.3	2.5	1.0	0.5	0.5
Blood White Count	0.1	1.0	3.0	-1.7	-0.8	-0.4	-0.3
Heel T-Score	13.5	107.2	240.2	7.2	11.6	15.5	1.4
BMI	0.3	1.9	6.7	0.7	0.7	-2.6	0.0
Height	0.6	12.0	32.8	2.8	2.8	-0.1	-5.7
Waist Hip Ratio (WHR)	0.2	0.7	1.1	-1.0	-1.1	-0.7	-0.6
Systolic Blood Pressure	0.1	0.7	1.6	1.3	0.6	0.1	0.9
Smoking Status	0.4	0.9	1.4	0.9	1.2	-0.7	-0.9
Allergy or Eczema	0.4	1.0	2.2	1.5	-0.5	-1.1	0.5
Cardiovascular Disease	0.0	0.2	0.2	0.4	-0.4	-0.3	-0.5
Hypothyroidism (self reported)	0.7	1.6	2.7	-0.7	-1.6	-1.0	1.4
Respiratory disease	0.5	1.1	2.8	1.0	0.9	-1.7	-0.1
Type 2 Diabetes (T2D) (2018)	0.8	1.5	3.0	1.3	1.0	-1.7	-0.7
Lung FEV1/FVC ratio	0.2	0.9	1.7	0.0	-1.0	1.0	-1.3
Lung FVC	0.4	2.0	3.8	-1.9	-0.2	0.9	-1.9
Neuroticism	0.1	0.2	0.3	-0.6	0.1	-0.4	-0.5
Chronotype (morning person)	1.2	2.9	9.0	0.2	1.6	3.0	0.1
Hair Pigment	0.0	0.7	1.7	0.6	0.8	1.3	0.0
Tanning	0.0	0.5	1.4	-1.2	-0.6	0.3	0.5
Hand grip strength (left)	1.8	4.7	7.5	2.7	2.6	-1.6	-1.4
Number of treatments/medications taken	0.1	0.3	0.8	0.4	0.2	-0.9	-0.2
Average weekly spirits intake	0.3	0.4	1.3	0.1	-1.2	0.4	-0.2
Sensitivity / hurt feelings	0.1	0.1	0.3	-0.4	0.6	0.0	-0.3
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-1.3	-0.2	0.8	0.8
Hearing difficulty/problems: Yes	1.7	2.6	4.4	-2.1	-1.9	0.8	-1.3
Relative age of first facial hair	1.3	2.8	4.6	1.6	1.9	-2.2	-0.2
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	4.8	-2.2	-1.8	-1.4	-0.5
Ever used hormone-replacement therapy (HRT)	1.5	2.0	5.4	1.1	0.0	-2.3	-1.1
Ever had hysterectomy (womb removed)	1.4	1.6	5.0	-0.5	-0.5	2.2	1.0
Systolic blood pressure, automated reading	0.3	0.7	2.1	0.2	-0.9	0.0	1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	1.6	-0.1	1.3	-0.6	-0.9
Angina	0.7	0.9	1.6	1.0	0.2	0.9	1.3
Medication for hormone replacement therapy	0.4	0.5	1.5	0.6	-0.0	-0.2	1.2
Vitamin and mineral supplements	1.1	1.5	2.1	1.2	1.4	-1.4	-0.7
Supplements: Zinc	1.2	1.3	3.0	-0.7	-1.1	0.6	1.7
Medication: Co-codamol	0.4	0.4	1.1	-0.3	-0.6	-1.1	-0.0
Medication: Metformin	0.3	0.5	1.1	0.1	0.9	-1.0	-0.1
Diabetes (father)	0.1	0.2	0.5	0.3	0.0	0.7	-0.3
Diabetes (mother)	0.7	0.9	1.8	1.3	0.2	0.3	1.3
Severe depression (siblings)	0.2	0.2	0.6	0.5	-0.2	-0.8	0.2
Pack years adult smoking proportion	0.9	1.4	4.9	-0.3	0.9	-0.1	2.2
Impedance of leg (right)	0.8	3.8	13.0	-0.8	-1.1	3.6	0.2
Leg fat-free mass (left)	1.2	6.3	8.9	2.5	3.0	-3.0	-1.1
Trunk fat percentage	0.2	0.9	1.9	0.8	1.4	-0.6	-0.7
Hand grip strength (right)	1.9	5.1	8.2	2.6	2.9	-1.9	-1.4
Townsend deprivation index at recruitment	0.2	0.3	1.1	-0.4	1.0	0.3	-0.0
Current tobacco smoking	0.1	0.1	0.2	0.2	0.3	-0.4	0.4
Average weekly fortified wine intake	0.3	0.4	1.0	0.5	-0.4	-0.5	1.0
Maternal smoking around birth	0.5	0.7	1.8	-0.5	-0.7	-1.4	0.5
Fed-up feelings	0.1	0.2	0.6	0.2	0.8	-0.0	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.7	1.1	-1.0	-0.9	0.9	0.5
Relative age voice broke	0.7	1.1	3.2	1.0	0.2	-1.8	-0.2
Taking other prescription medications	1.1	1.7	3.0	-1.7	-1.2	-1.4	-0.6
Age when periods started (menarche)	0.3	0.8	2.2	-0.4	0.9	-1.5	-0.2
Bilateral oophorectomy (both ovaries removed)	2.4	2.8	4.0	1.9	1.8	-0.4	2.0
Heel bone mineral density (BMD) T-score, automated (left)	5.0	11.5	30.4	2.3	3.2	5.5	-0.2
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.7	-0.6	-1.2	-1.6	1.3
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.3	0.7	-0.1	1.2
Serious illness, injury or assault to yourself	0.8	1.0	3.4	-0.0	-0.8	-0.3	1.9
High blood pressure	0.1	0.3	0.8	0.9	0.1	0.1	0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.5	1.2	-0.6	-0.9	0.3
Multivitamins +/- minerals	0.9	1.2	2.2	-0.8	-1.5	1.2	0.7
Stomach or abdominal pain in last month	0.8	1.0	2.1	-0.0	1.5	0.4	-1.3
Supplements: Glucosamine	0.6	0.8	1.7	1.3	-0.3	0.5	1.1
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	0.9	0.4	1.0	-0.3	0.6
Medication: Atenolol	1.0	1.2	3.5	-1.1	-0.4	0.2	-1.9
Medication: Levothyroxine sodium	0.6	1.1	3.6	-0.6	-1.9	-0.1	0.6
Sitting height	1.7	11.8	22.1	2.0	3.0	-3.5	-4.7
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.7	0.2	0.7	0.2
High blood pressure (mother)	0.6	0.8	1.9	1.4	0.3	0.8	0.8
Body mass index (BMI)	0.6	2.6	7.7	0.8	1.4	-2.8	-0.1
Impedance of leg (left)	1.0	4.7	14.7	-1.1	-1.6	3.8	-0.5
Leg predicted mass (left)	1.2	6.2	8.8	2.5	3.0	-3.0	-1.0
Trunk fat mass	0.4	1.8	2.8	1.2	1.7	-1.3	-1.2
Waist circumference	1.0	3.5	9.0	1.4	1.4	-3.0	-1.1
Number of incorrect matches in round	0.1	0.2	0.3	0.2	0.5	0.5	-0.5
Past tobacco smoking	0.1	0.2	0.3	0.1	-0.4	0.5	0.6
Alcohol usually taken with meals	0.3	0.5	0.8	0.7	-0.3	-0.8	-0.9
Nervous feelings	0.6	1.1	1.9	-1.4	-0.6	1.4	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	1.2	-0.1	0.3	0.2	-1.1
Hearing difficulty/problems with background noise	1.7	2.8	7.4	-1.2	-2.7	0.4	-1.4
Hair/balding pattern: Pattern 2	0.7	0.9	1.7	-1.0	0.5	0.7	-1.3
Had menopause	0.4	0.5	1.4	-0.3	-1.2	-0.2	-0.6
Had other major operations	1.3	1.6	5.1	0.7	-0.8	-0.3	2.2
Forced vital capacity (FVC)	0.6	2.2	5.2	0.5	1.7	0.7	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	5.5	12.5	21.0	3.3	4.2	4.6	-0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.5	-0.6	-1.0	-1.9	1.3
Qualifications: None of the above	1.3	2.8	4.2	-2.0	-0.8	1.6	-2.0
Financial difficulties in last 2 years	0.3	0.4	1.0	0.1	-0.0	-1.0	0.6
Mouth/teeth dental problems	0.3	0.5	1.5	0.1	-0.1	-1.2	0.8
Heart attack	0.2	0.3	0.5	0.5	0.6	-0.7	0.1
Allergy	0.5	1.2	4.2	0.3	2.1	0.5	-0.3
Pain all over the body in last month	0.7	0.7	2.4	-1.5	-0.5	0.2	-0.4
Diabetes (self-reported)	0.2	0.3	0.5	0.6	0.6	-0.7	-0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.2	0.5	-0.0	-1.8	-0.3
Medication: Ramipril	1.0	1.3	2.5	1.6	1.6	-0.0	0.7
Medication: Simvastatin	0.1	0.1	0.3	0.5	-0.3	-0.5	-0.0
Fluid intelligence score	0.4	0.8	2.2	0.2	-0.7	1.5	0.6
Illnesses of siblings	0.2	0.3	0.6	-0.2	0.7	0.3	0.8
Neuroticism score	0.1	0.2	0.3	-0.5	0.3	-0.2	-0.5
Weight	0.9	4.6	6.8	1.9	2.3	-2.6	-1.7
Impedance of arm (right)	1.3	5.9	23.1	-0.3	-0.7	4.8	-0.0
Arm fat percentage (right)	0.1	0.3	0.6	0.2	0.8	-0.6	-0.3
Trunk fat-free mass	0.9	4.9	7.6	2.3	2.0	-2.8	-1.6
Hip circumference	1.1	4.8	8.2	1.9	2.2	-2.9	-1.6
Time employed in main current job	0.0	0.0	0.1	0.2	-0.1	-0.2	0.3
Alcohol intake versus 10 years previously	0.5	0.8	1.8	-1.4	0.2	1.1	0.3
Father’s age at death	2.0	2.7	4.9	-2.2	-1.3	0.7	-1.9
Worrier / anxious feelings	0.2	0.3	0.8	-0.2	-0.0	-0.7	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.9	0.7	-0.2	-0.6	-0.9
Falls in the last year	0.3	0.4	1.2	0.6	-0.2	-0.4	1.1
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.5	-0.4	0.1	-0.0
Number of live births	0.3	0.4	1.1	-0.1	-1.1	-0.4	-0.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.2	5.6	0.9	1.6	0.1	-2.4
Pulse rate	2.1	3.6	7.3	2.7	1.8	-0.5	1.9
Happiness	1.3	1.6	3.0	-0.3	1.0	-1.5	-1.7
Noisy workplace	1.3	1.7	3.4	1.8	1.1	-1.4	0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	0.2	-0.5	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.0	-1.4	-0.1	-0.8	-0.9
Mouth/teeth dental problems: Dentures	1.5	2.5	6.5	0.8	1.6	0.1	-2.6
Asthma	0.2	0.5	1.2	0.5	-0.5	0.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.3	-0.6	-1.1	-0.3	-0.4
Medication: Cholesterol lowering	0.6	0.9	2.0	-0.8	-0.8	-1.4	-0.6
Depression (self-reported)	0.3	0.3	0.7	-0.2	0.2	-0.7	-0.8
Medication: Lansoprazole	0.8	0.9	1.9	-0.4	0.6	-1.4	-1.1
Prospective memory result	0.8	1.0	3.1	-0.6	-0.8	-0.1	1.8
Lung cancer (father)	1.0	1.2	2.0	1.4	0.8	1.3	-0.7
Illnesses of mother	0.7	0.8	1.8	-0.6	-0.6	-1.3	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.9	2.8	6.8	1.0	1.8	0.4	-2.6
Pulse wave Arterial Stiffness index	1.2	1.4	4.7	0.4	0.8	2.2	0.4
Impedance of arm (left)	1.0	4.7	17.8	-0.7	-0.8	4.2	-0.1
Arm fat mass (right)	0.4	1.6	3.4	0.8	1.3	-1.9	-0.8
Trunk predicted mass	0.8	4.7	7.6	2.2	2.0	-2.8	-1.5
Standing height	0.6	6.0	13.8	2.2	2.2	0.2	-3.7
Length of working week for main job	0.1	0.2	0.2	-0.3	-0.5	0.3	0.5
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.5	0.0	-0.3	-0.9
Breastfed as a baby	0.8	1.0	2.6	0.3	0.0	1.1	1.6
Tense / ‘highly strung’	0.7	1.1	2.6	-1.2	-1.6	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	5.8	0.7	0.7	-2.4	0.3
Hair/balding pattern: Pattern 4	0.9	2.2	4.1	1.3	1.5	2.0	0.9
Birth weight of first child	0.5	1.0	2.0	-1.3	-1.4	0.2	0.3
Peak expiratory flow (PEF)	0.3	0.7	1.8	0.6	0.6	0.2	-1.3
Pulse wave reflection index	1.2	1.4	5.2	0.2	-0.4	2.3	-0.5
Ever highly irritable/argumentative for 2 days	1.7	2.0	3.6	1.5	1.5	-0.2	1.9
Loud music exposure frequency	1.0	1.1	4.0	0.2	0.3	-2.0	-0.4
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	4.4	2.1	1.4	-1.7	-0.4
Mouth/teeth dental problems: Bleeding gums	0.3	0.5	0.9	-0.6	-0.9	0.7	0.0
Blood clot in the leg (DVT)	1.3	1.7	2.5	-0.8	-1.2	1.5	1.6
Medication: Paracetamol	0.7	1.1	2.3	0.2	0.8	-1.2	-1.5
Headache pain in last month	0.2	0.4	0.8	-0.9	-0.1	0.1	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.5	-0.6	-1.2	0.7	0.0
Glaucoma (self-reported)	1.5	1.8	3.8	-1.8	-1.9	0.4	0.4
Gout (self-reported)	1.9	2.6	5.6	-2.4	-0.3	1.6	-1.5
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	6.1	-1.0	-2.5	-0.8	1.0
Medication: Amlodipine	1.1	1.5	3.2	1.6	1.8	0.3	-0.4
Medication: Ventolin 100micrograms inhaler	3.5	4.5	9.1	-2.9	-3.0	-0.1	-0.4
Birth weight	0.2	0.4	1.0	-0.2	1.0	0.3	-0.7
Chronic bronchitis/emphysema (mother)	0.9	1.0	3.0	-0.4	1.7	-0.2	-0.9
High blood pressure (siblings)	0.6	0.9	2.8	1.7	0.7	-0.3	-0.4
Forced vital capacity (FVC), Best measure	0.9	3.4	6.8	1.1	2.3	0.6	-2.6
Body fat percentage	0.1	0.6	1.1	0.7	1.0	-0.7	-0.4
Leg fat percentage (right)	0.2	0.8	2.1	0.7	0.9	-1.4	0.0
Arm fat-free mass (right)	1.4	7.2	14.7	2.3	2.5	-3.8	-1.6
Exposure to tobacco smoke outside home	1.1	1.4	4.0	2.0	1.1	0.6	0.2
Comparative body size at age 10	0.1	0.4	1.2	-1.1	-0.5	-0.2	0.4
Number of full brothers	0.4	0.5	1.5	-1.2	-0.3	0.2	-0.7
Worry too long after embarrassment	0.2	0.4	1.2	0.3	0.3	-0.5	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	0.7	0.7	0.7	-0.8	-0.1
Wheeze or whistling in the chest in last year	1.2	2.1	7.5	0.6	0.6	0.2	2.7
Number of children fathered	1.1	1.2	2.3	-1.2	-1.1	-0.3	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.4	0.3	1.2	0.4	-0.4
Age at first live birth	0.2	0.3	0.7	-0.2	-0.8	-0.1	0.7
Pulse wave peak to peak time	1.1	1.3	4.1	-0.6	-0.7	-2.0	-0.6
Health satisfaction	0.4	0.6	1.7	0.7	0.1	-1.3	0.2
Shortness of breath walking on level ground	0.9	1.1	3.0	-0.1	0.6	-1.0	1.7
Qualifications: College or University degree	0.3	0.8	2.5	0.6	-0.2	-0.6	1.6
Eye problems/disorders: None of the above	0.7	0.8	2.7	0.0	0.6	-0.3	-1.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	0.8	-0.8	-0.7	0.9	-0.6
Emphysema/chronic bronchitis	2.5	2.8	6.2	-2.5	-2.1	-0.0	0.5
Medication for pain relief, constipation, heartburn	1.0	1.7	3.3	1.1	1.8	0.7	1.3
Neck or shoulder pain in last month	1.0	1.4	4.5	-0.8	-2.1	-0.5	0.5
Medication: Blood pressure	1.4	2.5	5.8	1.7	2.4	-1.1	0.0
Angina (self-reported)	0.6	0.8	1.5	0.6	-0.2	1.1	1.2
Migraine (self-reported)	0.9	1.1	1.8	-1.3	-1.0	0.1	1.3
Medication: Ibuprofen	0.3	0.3	0.7	-0.5	-0.8	-0.3	-0.6
Medication: Allopurinol	2.2	2.9	6.2	-2.5	-0.9	1.7	-1.4
Medication: Omeprazole	1.2	1.4	2.0	-1.4	0.4	-1.4	-1.3
Medication: Seretide 50 evohaler	0.4	0.5	1.5	0.4	0.4	-0.1	1.2
Mean time to correctly identify matches	0.3	0.5	0.9	-1.0	-1.0	0.1	-0.6
Heart disease (mother)	0.4	0.5	1.5	1.2	0.7	-0.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.6	1.0	-0.6	-1.6	0.8
Whole body fat mass	0.5	2.0	3.1	1.3	1.8	-1.5	-1.0
Leg fat mass (right)	0.6	2.2	3.9	1.2	1.7	-2.0	-0.8
Arm predicted mass (right)	1.3	6.7	13.8	2.2	2.4	-3.7	-1.6
Pulse rate, automated reading	0.6	2.0	2.5	1.6	1.4	-1.5	1.1
Alcohol intake frequency.	0.1	0.3	0.7	-0.3	-0.6	-0.8	-0.0
Comparative height size at age 10	0.3	1.7	5.0	1.1	0.5	0.6	-2.2
Number of full sisters	0.8	1.0	2.3	-1.5	-1.1	-0.6	-0.1
Suffer from ‘nerves’	0.2	0.3	1.0	-1.0	-0.1	-0.3	-0.2
Overall health rating	0.4	0.8	2.4	0.2	-0.5	-1.6	0.7
Chest pain or discomfort	0.5	0.7	2.2	1.5	0.3	-0.5	-0.6
Had major operations	0.2	0.3	0.9	0.2	-0.9	-0.3	-0.1
Age at last live birth	0.4	0.6	2.0	-0.7	-1.4	-0.2	0.4
Family relationship satisfaction	1.8	2.2	3.2	1.6	1.7	-1.8	-0.3
Leg pain on walking	0.6	0.8	1.7	0.3	1.1	-1.3	-0.3
Qualifications: NVQ or HND or HNC or equivalent	2.4	2.9	6.2	2.2	2.5	-0.3	0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	0.8	-0.7	-0.0	-0.8	-0.9
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.3	1.4	1.0	1.5	0.3
Medication: Aspirin	0.9	1.2	2.4	0.7	-1.5	-0.8	1.2
Supplements: Vitamin C	0.5	0.6	0.8	0.9	0.8	-0.6	0.9
Knee pain experienced in last month	2.7	4.2	7.3	1.2	1.8	-2.7	-2.2
Hypertension (Self-reported)	0.1	0.2	0.5	0.7	-0.1	0.1	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.4	-0.5	1.2	-1.0	-0.9
Illnesses of father: Heart disease	0.2	0.3	1.1	-0.0	-0.5	-0.0	1.0
Illnesses of siblings: Diabetes	0.2	0.3	0.8	-0.9	-0.6	0.2	-0.1
Smoking status: Previous	0.3	0.5	1.0	0.7	1.0	-0.7	-0.3
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	1.0	1.0	0.7	-0.0	0.1
Whole body fat-free mass	1.0	5.7	9.1	2.3	2.4	-3.0	-1.5
Leg fat-free mass (right)	1.1	5.9	8.4	2.4	2.7	-2.9	-1.4
Arm fat percentage (left)	0.2	0.6	1.3	0.4	0.9	-1.1	-0.4
Average weekly red wine intake	0.9	1.4	2.6	1.1	-1.6	-0.2	1.3
Handedness (chirality/laterality): Left-handed	1.1	1.3	1.9	1.2	1.2	1.4	-0.7
Mood swings	0.3	0.5	1.0	-0.6	-0.8	0.2	1.0
Loneliness, isolation	0.2	0.3	0.8	0.3	0.9	-0.5	0.4
Long-standing illness, disability or infirmity	0.6	0.9	2.4	1.0	0.5	-1.6	0.3
Ever had bowel cancer screening	0.5	0.6	1.3	-1.0	-1.2	0.2	-0.0
Diabetes diagnosed by doctor	0.5	0.7	1.0	1.0	1.0	-0.9	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	3.9	-1.6	-2.0	-0.4	-0.6
Friendships satisfaction	1.1	1.3	3.2	-1.2	-0.6	1.8	0.6
Qualifications: nursing, teaching	0.8	1.2	2.7	0.6	-0.9	-1.6	-1.0
Commuting to job workplace: Walk	0.9	0.9	1.4	-0.3	-1.0	1.2	1.2
Eye problems/disorders: Cataract	1.6	1.9	6.3	0.1	-0.4	2.5	1.1
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.5	-0.8	-0.7	0.8	1.2
Medication for cholesterol	0.8	1.3	4.2	-2.0	-0.5	0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	3.6	-1.0	-1.9	-0.7	1.1
Back pain experienced in last month	1.5	2.1	7.0	0.8	0.8	-2.7	-0.4
Mineral and other dietary supplements	0.4	0.5	0.9	-0.5	0.7	-0.5	-0.9
Breast cancer (self-reported)	1.3	1.5	4.8	0.8	-0.8	0.2	2.2
Asthma (self-reported)	0.2	0.4	1.0	0.3	-0.6	0.1	1.0
Osteoporosis (self-reported)	4.4	5.4	20.8	-0.8	0.2	-4.6	0.4
Osteoarthritis (self-reported)	0.6	0.8	2.3	0.3	-0.6	0.5	1.5
Medication: Aspirin	1.1	1.4	2.2	0.9	-1.5	-0.5	1.5
Medication: Gliclazide	2.7	3.1	5.4	1.9	1.6	-2.3	-0.9
Illnesses of father: None of the above (group 1)	0.1	0.1	0.2	0.4	0.2	0.5	0.2
Smoking status: Current	0.0	0.1	0.2	-0.3	-0.0	-0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.0	0.6	1.7	1.0	-1.1
Whole body water mass	1.0	5.4	8.9	2.3	2.3	-3.0	-1.5
Leg predicted mass (right)	1.1	5.8	8.4	2.4	2.7	-2.9	-1.3
Arm fat mass (left)	0.5	2.0	4.4	0.7	1.5	-2.1	-0.9
Number of self-reported non-cancer illnesses	0.5	1.0	1.3	-0.5	-1.1	-1.0	1.1
Average weekly champagne plus white wine intake	0.1	0.1	0.4	0.4	-0.1	-0.1	-0.6
Miserableness	0.2	0.3	0.6	0.5	-0.1	-0.8	0.6
Guilty feelings	0.2	0.2	0.6	0.0	0.5	-0.8	0.3
Wears glasses or contact lenses	0.2	0.2	0.7	0.0	0.8	0.1	-0.1
Ever taken oral contraceptive pill	1.0	1.1	2.8	0.2	-1.0	-1.7	0.9
Hearing aid user	0.2	0.3	0.4	0.5	0.6	0.3	-0.5
Mother’s age at death	0.6	0.8	2.1	-0.1	0.0	1.0	-1.5
Financial situation satisfaction	0.0	0.0	0.1	-0.0	0.0	0.2	0.4
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.7	0.4	0.8	-0.6	0.8
Commuting to job workplace: Public transport	0.3	0.4	1.0	0.1	0.7	1.0	0.1
Eye problems/disorders: Glaucoma	2.5	2.9	6.3	-1.8	-2.5	0.6	1.4
Medication: Blood pressure	0.7	1.3	4.2	2.1	-0.6	-0.4	0.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.2	0.4	-0.2	-1.1	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.2	1.1	0.1	0.4	0.0
High cholesterol (Self-reported)	0.4	0.7	1.5	0.6	-0.4	-1.2	-1.0
Medication: Bendroflumethiazide	1.5	2.2	4.8	2.2	-0.2	-1.7	1.1
Medication: Paracetamol	1.1	1.7	2.7	0.7	1.1	-1.6	-1.6
Medication: Lisinopril	0.8	1.0	2.9	1.7	0.3	-0.2	1.0
Medication: Atorvastatin	0.6	0.7	2.6	0.4	0.1	-1.6	0.4
Illnesses of father: High blood pressure	0.8	1.0	1.7	-0.6	-1.3	-0.7	1.1
Alcohol drinker status: Never	0.8	1.0	3.2	1.8	0.6	-0.5	0.1
Ever smoked	0.1	0.2	0.5	-0.2	-0.1	0.1	0.7
Basal metabolic rate	1.0	5.8	9.0	2.3	2.5	-3.0	-1.6
Leg fat percentage (left)	0.3	0.9	2.6	0.7	0.7	-1.6	-0.4
Arm fat-free mass (left)	0.9	4.8	9.8	1.8	2.0	-3.1	-1.5
Number of operations (self-reported)	0.9	1.3	2.9	0.7	-1.3	-0.6	1.7
Average weekly beer plus cider intake	0.4	0.5	1.6	0.3	1.3	-0.7	-0.0
Irritability	0.3	0.4	1.2	-0.5	-0.5	-0.2	-1.1
Risk taking	2.1	3.0	5.8	-1.4	-2.1	-0.1	2.4
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	0.7	0.6	1.5	-0.4
Fractured/broken bones in last 5 years	1.7	2.2	3.4	-1.5	-1.8	-1.7	0.2
Age started oral contraceptive pill	0.6	0.7	1.9	0.1	-0.7	-1.4	-0.7
Diastolic blood pressure, automated reading	0.5	1.5	2.4	1.5	0.7	-0.8	1.6
Ever depressed for a whole week	0.8	1.0	1.5	-0.6	-1.2	-1.2	0.8
Unable to work because of sickness or disability	0.3	0.3	0.6	-0.8	0.4	-0.7	0.3
Commuting to job workplace: Cycle	1.1	1.3	2.7	1.3	0.1	-1.7	0.9
Myopia	0.1	0.1	0.3	0.5	0.0	-0.1	0.4
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.9	-1.4	-0.2	0.2	-1.0
Cholesterol lowering medication	0.5	0.8	1.6	1.0	0.2	-1.3	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	-0.7	0.9	-1.2	-0.7
Pain experienced in last month	1.9	3.2	7.7	0.8	-0.4	2.8	2.1
Supplements: Calcium	1.8	2.0	3.3	-0.9	-1.7	-0.9	1.8
Basal cell carcinoma (self-reported)	1.0	1.2	2.7	-0.8	-1.6	-0.5	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.7	0.7	0.3	-0.9	0.2
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.1	-0.8	-1.2	1.4	1.8
Heart disease (siblings)	0.7	0.9	1.9	-0.1	-1.4	0.1	1.3
Alcohol drinker status: Previous	1.4	1.6	4.4	-0.1	-1.4	0.1	2.1
Pack years of smoking	0.8	1.2	4.0	-0.8	0.3	0.2	2.0
Impedance of whole body	1.0	4.9	17.5	-1.0	-0.9	4.2	-0.4
Leg fat mass (left)	0.6	2.4	4.3	1.1	1.7	-2.1	-1.0
Arm predicted mass (left)	1.3	6.8	12.7	2.3	2.6	-3.6	-1.7