[Hub]/) : Traits : Heel bone mineral density (BMD) T-score, automated (left) : ← →

chr11:45,945,837-48,285,906

Best TWAS P=9.3e-16 · Best GWAS P=5.38e-17 conditioned to 0.00223

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
10	GTEx	Esophagus Mucosa	ARFGAP2	0.05	0.06	lasso	4	0.05	4.4e-04	8.0	8.0	9.3e-16	0.83	0.08	0.76	TRUE
33	GTEx	Skin Sun Exposed Lower leg	ARHGAP1	0.08	0.01	lasso	5	0.02	1.4e-02	7.1	-8.0	1.1e-15	-0.91	0.03	0.90	FALSE
22	GTEx	Pancreas	LRP4	0.11	0.10	enet	16	0.14	1.8e-06	8.0	-7.8	8.7e-15	-0.83	0.03	0.96	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	C11orf49	0.02	0.02	blup	322	0.02	3.3e-04	7.9	7.7	1.0e-14	0.83	0.09	0.91	FALSE
31	GTEx	Skin Sun Exposed Lower leg	DDB2	0.08	0.10	lasso	4	0.10	5.8e-09	7.9	7.7	1.6e-14	0.77	0.19	0.81	FALSE
24	GTEx	Pancreas	LRP4-AS1	0.10	0.08	lasso	6	0.12	1.4e-05	8.0	-7.6	2.7e-14	-0.87	0.04	0.96	FALSE
19	GTEx	Nerve Tibial	ARHGAP1	0.10	0.03	enet	14	0.05	9.7e-05	6.4	-7.5	5.7e-14	-0.88	0.02	0.98	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	ARHGAP1	0.06	0.01	lasso	9	0.00	2.8e-01	6.6	-7.4	1.2e-13	-0.84	0.12	0.30	FALSE
5	GTEx	Artery Tibial	ZNF408	0.10	0.00	lasso	6	0.04	2.0e-04	7.1	-7.4	1.8e-13	-0.71	0.15	0.58	FALSE
23	GTEx	Pancreas	ARHGAP1	0.09	0.06	lasso	7	0.04	6.4e-03	7.1	-7.3	3.1e-13	-0.87	0.05	0.77	FALSE
2	GTEx	Adipose Subcutaneous	ARHGAP1	0.08	0.03	lasso	6	0.05	3.4e-05	6.6	-7.3	3.5e-13	-0.80	0.51	0.38	FALSE
7	GTEx	Breast Mammary Tissue	ARHGAP1	0.05	0.00	enet	14	0.01	1.3e-01	7.1	-7.2	4.1e-13	-0.79	0.03	0.77	FALSE
49	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF408	0.02	0.00	blup	27	0.02	4.3e-03	6.1	-7.2	7.1e-13	-0.85	0.01	0.77	FALSE
17	GTEx	Muscle Skeletal	ARHGAP1	0.03	0.05	lasso	2	0.04	1.2e-04	7.1	-7.1	1.4e-12	-0.89	0.04	0.93	FALSE
1	CommonMind	Brain Pre-frontal Cortex	LRP4	0.04	0.05	lasso	4	0.04	6.6e-06	6.6	7.0	1.7e-12	0.69	0.61	0.38	FALSE
26	GTEx	Prostate	ZNF408	0.19	0.10	lasso	2	0.10	1.6e-03	6.6	-7.0	2.9e-12	-0.70	0.14	0.08	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	CKAP5	0.11	0.04	lasso	3	0.03	2.1e-02	8.0	7.0	3.0e-12	0.76	0.08	0.74	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARHGAP1	0.05	0.04	blup	26	0.05	1.1e-05	7.1	-6.9	4.9e-12	-0.83	0.00	1.00	FALSE
21	GTEx	Ovary	ARHGAP1	0.25	0.09	lasso	16	0.18	3.8e-05	4.7	-6.9	5.0e-12	-0.79	0.13	0.56	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARHGAP1	0.02	0.01	blup	26	0.02	2.7e-04	7.1	-6.8	7.4e-12	-0.82	0.00	0.95	FALSE
25	GTEx	Prostate	CELF1	0.17	0.16	lasso	2	0.12	6.2e-04	6.6	6.6	4.3e-11	0.63	0.08	0.61	FALSE
12	GTEx	Esophagus Muscularis	ARHGAP1	0.07	0.08	lasso	3	0.07	6.1e-05	6.1	-6.6	4.8e-11	-0.82	0.13	0.85	FALSE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ARHGAP1	0.11	0.01	blup	26	0.03	2.7e-02	3.6	-6.5	5.7e-11	-0.78	0.01	0.56	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	DDB2	0.07	0.02	enet	13	0.04	3.5e-03	4.1	6.5	7.9e-11	0.74	0.11	0.33	FALSE
15	GTEx	Liver	ZNF408	0.10	0.09	lasso	3	0.08	3.5e-03	6.4	-6.5	8.7e-11	-0.81	0.07	0.40	FALSE
11	GTEx	Esophagus Muscularis	CKAP5	0.05	0.03	lasso	4	0.04	3.3e-03	6.1	6.2	5.3e-10	0.71	0.27	0.38	FALSE
4	GTEx	Artery Aorta	CKAP5	0.09	0.12	lasso	1	0.07	1.2e-04	6.1	6.1	9.6e-10	0.76	0.55	0.41	FALSE
41	ROSMAP	Brain Pre-frontal Cortex	DDB2	0.04	0.03	enet	15	0.03	7.1e-05	6.6	-6.0	1.7e-09	-0.46	0.90	0.03	FALSE
40	ROSMAP	Brain Pre-frontal Cortex	LRP4	0.04	0.06	blup	286	0.05	3.5e-07	4.6	6.0	1.8e-09	0.64	0.86	0.14	FALSE
3	GTEx	Adipose Visceral Omentum	ARHGAP1	0.12	0.02	enet	15	0.04	3.8e-03	6.4	-5.9	4.5e-09	-0.71	0.08	0.35	FALSE
6	GTEx	Brain Cerebellum	PACSIN3	0.27	0.00	lasso	12	0.01	2.2e-01	4.4	5.8	5.0e-09	0.65	0.08	0.22	FALSE
18	GTEx	Nerve Tibial	LRP4	0.28	0.24	enet	24	0.30	3.5e-21	-3.6	5.8	5.7e-09	0.69	0.68	0.32	FALSE
37	METSIM	Adipose	DDB2	0.03	0.03	lasso	2	0.02	1.9e-04	5.5	-5.8	5.9e-09	-0.57	0.39	0.54	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf49	0.05	0.00	blup	90	0.02	3.0e-04	5.2	5.7	1.1e-08	0.56	0.14	0.46	FALSE
20	GTEx	Nerve Tibial	LRP4-AS1	0.23	0.16	enet	15	0.24	1.1e-16	-3.6	5.7	1.2e-08	0.65	0.85	0.15	FALSE
13	GTEx	Heart Left Ventricle	ACP2	0.11	0.06	enet	18	0.10	9.2e-06	4.1	-5.7	1.5e-08	-0.60	0.62	0.24	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	ACP2	0.08	0.06	enet	7	0.06	1.6e-04	5.5	-5.5	3.0e-08	-0.56	0.01	0.62	FALSE
32	GTEx	Skin Sun Exposed Lower leg	PACSIN3	0.17	0.11	lasso	4	0.12	5.5e-10	3.1	5.5	3.1e-08	0.67	0.86	0.14	FALSE
38	METSIM	Adipose	RAPSN	0.11	0.01	enet	21	0.06	7.9e-09	7.4	5.5	3.1e-08	0.52	0.22	0.77	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	ZNF408	0.27	0.01	blup	27	0.09	1.5e-03	5.1	-5.5	3.2e-08	-0.56	0.02	0.20	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	PACSIN3	0.11	0.05	lasso	3	0.10	3.4e-06	3.1	5.5	3.7e-08	0.67	0.31	0.52	FALSE
34	GTEx	Spleen	ACP2	0.19	-0.01	lasso	5	0.04	4.1e-02	5.5	-5.5	4.0e-08	-0.58	0.11	0.14	FALSE
39	NTR	Blood	DDB2	0.01	0.00	lasso	7	0.01	2.2e-03	5.5	-5.5	4.5e-08	-0.50	0.31	0.05	FALSE
36	METSIM	Adipose	ARHGAP1	0.08	0.02	enet	23	0.06	3.6e-09	8.4	-5.4	5.7e-08	-0.76	0.01	0.99	FALSE
14	GTEx	Heart Left Ventricle	ARHGAP1	0.06	0.03	lasso	2	0.02	2.1e-02	4.6	-5.4	6.4e-08	-0.68	0.12	0.50	FALSE
8	GTEx	Breast Mammary Tissue	ATG13	0.10	0.00	lasso	3	0.00	3.7e-01	4.8	-5.4	7.1e-08	-0.61	0.08	0.09	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ATG13	0.12	0.07	lasso	5	0.06	3.3e-04	4.9	-5.3	1.3e-07	-0.54	0.89	0.02	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ACP2	0.03	0.03	blup	44	0.04	3.5e-05	5.3	-5.2	1.9e-07	-0.57	0.40	0.49	FALSE
35	GTEx	Testis	LRP4	0.17	0.00	lasso	3	-0.01	7.8e-01	5.9	-5.2	2.1e-07	-0.61	0.04	0.09	FALSE
46	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CKAP5	0.09	0.01	blup	58	0.04	2.9e-03	6.2	5.2	2.1e-07	0.61	0.10	0.41	FALSE
16	GTEx	Liver	ARHGAP1	0.12	0.05	enet	4	0.05	1.5e-02	4.0	-5.2	2.5e-07	-0.62	0.06	0.40	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	PACSIN3	0.09	0.01	enet	5	0.03	3.1e-04	3.3	5.1	3.0e-07	0.60	0.02	0.85	FALSE