Best TWAS P=2.1e-46 · Best GWAS P=5.57e-66 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EML6 | 0.06 | 0.00 | blup | 675 | 0.03 | 9.2e-05 | -8.66 | -9.3 | 1.1e-20 | 0.00 | 0.58 | 0.01 | FALSE |
| 2 | GTEx | Artery Aorta | AC093110.3 | 0.13 | 0.14 | lasso | 8 | 0.10 | 4.5e-06 | 8.47 | 8.4 | 5.3e-17 | 0.03 | 0.99 | 0.00 | FALSE |
| 3 | GTEx | Artery Tibial | SPTBN1 | 0.21 | 0.14 | lasso | 5 | 0.15 | 1.1e-11 | 8.47 | 6.0 | 1.6e-09 | 0.03 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Tibial | AC093110.3 | 0.11 | 0.14 | lasso | 3 | 0.14 | 2.5e-11 | 8.47 | 8.4 | 2.9e-17 | 0.03 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Female) | AC093110.3 | 0.11 | 0.00 | lasso | 3 | 0.00 | 2.2e-01 | 6.97 | 8.2 | 3.7e-16 | 0.08 | 0.06 | 0.05 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | AC093110.3 | 0.21 | 0.13 | lasso | 6 | 0.11 | 1.3e-08 | -8.64 | 8.9 | 8.0e-19 | -0.03 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Pancreas | EML6 | 0.34 | 0.11 | lasso | 10 | 0.13 | 3.9e-06 | 8.07 | -6.9 | 5.0e-12 | 0.00 | 0.94 | 0.00 | FALSE |
| 8 | GTEx | Prostate | HMGB1P31 | 0.53 | 0.19 | enet | 25 | 0.27 | 1.5e-07 | 0.11 | -6.2 | 7.5e-10 | -0.40 | 0.49 | 0.17 | FALSE |
| 9 | GTEx | Thyroid | EML6 | 0.26 | 0.20 | enet | 46 | 0.24 | 5.8e-18 | 7.27 | -6.1 | 8.6e-10 | 0.09 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Whole Blood | SPTBN1 | 0.13 | 0.04 | lasso | 6 | 0.08 | 5.7e-08 | -5.62 | -8.5 | 2.7e-17 | -0.13 | 0.99 | 0.00 | FALSE |
| 11 | METSIM | Adipose | EML6 | 0.05 | 0.06 | lasso | 3 | 0.05 | 1.5e-08 | 6.02 | 6.3 | 2.2e-10 | 0.00 | 1.00 | 0.00 | FALSE |
| 12 | NTR | Blood | ACYP2 | 0.02 | 0.02 | enet | 15 | 0.02 | 8.9e-07 | 2.64 | 6.3 | 3.4e-10 | 0.32 | 1.00 | 0.00 | TRUE |
| 13 | NTR | Blood | SPTBN1 | 0.06 | 0.04 | bslmm | 640 | 0.04 | 3.2e-14 | -9.52 | -12.8 | 1.9e-37 | -0.14 | 1.00 | 0.00 | TRUE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | TSPYL6 | 0.07 | 0.03 | lasso | 2 | 0.05 | 6.5e-07 | -4.92 | 5.7 | 9.6e-09 | 0.12 | 0.96 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | AC092839.1 | 0.10 | 0.07 | enet | 17 | 0.09 | 4.3e-12 | -8.02 | -7.4 | 1.5e-13 | 0.01 | 1.00 | 0.00 | TRUE |
| 16 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL23AP32 | 0.02 | 0.02 | blup | 50 | 0.02 | 1.1e-05 | -9.13 | -10.0 | 1.6e-23 | -0.03 | 0.03 | 0.96 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C2orf73 | 0.09 | 0.01 | lasso | 3 | 0.06 | 2.0e-07 | 2.83 | -5.5 | 3.3e-08 | 0.00 | 0.46 | 0.02 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EML6 | 0.14 | 0.13 | lasso | 4 | 0.13 | 1.0e-14 | -8.57 | -7.9 | 2.4e-15 | -0.01 | 0.09 | 0.91 | FALSE |
| 19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RPL23AP32 | 0.09 | 0.10 | lasso | 4 | 0.10 | 7.3e-11 | 5.99 | -8.1 | 5.6e-16 | -0.01 | 0.97 | 0.03 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | C2orf73 | 0.16 | 0.05 | enet | 12 | 0.06 | 2.4e-04 | -4.97 | -7.9 | 3.1e-15 | -0.24 | 0.48 | 0.10 | TRUE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C2orf73 | 0.19 | 0.08 | lasso | 6 | 0.16 | 2.8e-18 | -4.84 | -6.0 | 1.7e-09 | -0.09 | 1.00 | 0.00 | FALSE |
| 22 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RPL23AP32 | 0.05 | 0.03 | blup | 50 | 0.04 | 4.3e-05 | -8.45 | -10.0 | 1.0e-23 | -0.03 | 0.39 | 0.59 | FALSE |
| 23 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPTBN1 | 0.10 | 0.04 | lasso | 3 | 0.05 | 2.1e-06 | -8.61 | -7.3 | 2.3e-13 | -0.23 | 0.84 | 0.00 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C2orf73 | 0.29 | 0.13 | lasso | 4 | 0.17 | 1.4e-17 | 2.83 | -5.2 | 2.3e-07 | 0.00 | 1.00 | 0.00 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RPL23AP32 | 0.06 | 0.02 | enet | 6 | 0.03 | 1.7e-04 | -7.76 | -6.8 | 1.3e-11 | 0.02 | 0.16 | 0.42 | TRUE |
| 26 | The Cancer Genome Atlas | Soft Tissue Sarcoma | RPL23AP32 | 0.04 | 0.03 | blup | 50 | 0.02 | 1.2e-02 | -8.75 | -9.9 | 3.8e-23 | -0.02 | 0.01 | 0.85 | TRUE |
| 27 | The Cancer Genome Atlas | Thyroid Carcinoma | C2orf73 | 0.45 | 0.26 | lasso | 6 | 0.32 | 1.1e-31 | 2.87 | -5.2 | 2.4e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 28 | The Cancer Genome Atlas | Thyroid Carcinoma | EML6 | 0.05 | 0.05 | lasso | 4 | 0.05 | 3.1e-05 | 5.98 | -6.7 | 1.9e-11 | 0.03 | 0.86 | 0.03 | TRUE |
| 29 | The Cancer Genome Atlas | Thyroid Carcinoma | RPL23AP32 | 0.06 | 0.04 | blup | 50 | 0.03 | 1.3e-03 | -8.02 | -9.5 | 2.0e-21 | -0.01 | 0.07 | 0.74 | FALSE |
| 30 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SPTBN1 | 0.39 | 0.04 | blup | 163 | 0.12 | 3.6e-04 | -13.81 | -14.3 | 2.1e-46 | -0.49 | 0.04 | 0.46 | TRUE |