[Hub]/) : Traits : Pulse rate : ← →

chr3:48,012,797-51,043,528

Best TWAS P=1.04e-09 · Best GWAS P=2.01e-08 conditioned to 0.00611

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
62	GTEx	Testis	TRAIP	0.14	0.08	enet	22	0.08	1.9e-04	5.1	6.1	1.0e-09	-0.54	0.07	0.81	TRUE
31	GTEx	Heart Atrial Appendage	QRICH1	0.06	0.01	enet	7	0.01	1.2e-01	-5.2	-6.1	1.2e-09	0.80	0.08	0.64	FALSE
80	ROSMAP	Brain Pre-frontal Cortex	KLHDC8B	0.01	0.01	blup	255	0.01	1.0e-02	-4.0	-6.0	1.9e-09	0.78	0.08	0.38	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RHOA	0.03	0.02	blup	294	0.02	1.0e-03	-5.3	-6.0	2.3e-09	0.70	0.11	0.81	FALSE
72	GTEx	Whole Blood	AMT	0.07	0.08	enet	37	0.09	1.1e-08	-5.2	5.9	4.0e-09	-0.71	0.09	0.91	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	NICN1-AS1	0.23	0.09	lasso	13	0.05	2.1e-02	-5.2	-5.9	4.2e-09	0.67	0.07	0.63	FALSE
88	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NCKIPSD	0.11	0.03	blup	38	0.02	1.4e-02	-5.1	5.9	4.4e-09	-0.55	0.01	0.77	FALSE
92	The Cancer Genome Atlas	Lung Adenocarcinoma	NCKIPSD	0.07	0.01	blup	38	0.02	2.9e-03	-4.6	5.9	4.5e-09	-0.55	0.01	0.93	FALSE
58	GTEx	Small Intestine Terminal Ileum	QRICH1	0.12	0.03	enet	22	0.05	3.0e-02	-5.3	-5.9	4.7e-09	0.57	0.08	0.47	FALSE
34	GTEx	Heart Left Ventricle	AMT	0.07	0.02	lasso	7	0.02	4.6e-02	5.2	5.8	5.4e-09	-0.76	0.07	0.70	FALSE
22	GTEx	Cells Transformed fibroblasts	GPX1	0.07	0.10	lasso	5	0.10	1.2e-07	-5.3	-5.8	6.4e-09	0.77	0.08	0.92	FALSE
56	GTEx	Skin Sun Exposed Lower leg	GPX1	0.04	0.05	lasso	3	0.04	2.9e-04	-5.2	-5.8	6.4e-09	0.81	0.07	0.89	FALSE
90	The Cancer Genome Atlas	Lung Adenocarcinoma	AMT	0.02	0.00	blup	25	0.01	5.4e-02	-5.2	5.8	6.5e-09	-0.71	0.01	0.64	FALSE
83	YFS	Blood	AMT	0.15	0.18	lasso	12	0.19	1.6e-60	-5.3	5.8	6.9e-09	-0.70	0.08	0.92	FALSE
26	GTEx	Esophagus Gastroesophageal Junction	TCTA	0.17	0.06	lasso	15	0.03	3.8e-02	-5.5	5.8	7.7e-09	-0.93	0.07	0.84	FALSE
36	GTEx	Heart Left Ventricle	NICN1-AS1	0.09	0.00	enet	8	0.01	1.0e-01	5.0	5.7	1.1e-08	-0.78	0.07	0.60	FALSE
61	GTEx	Testis	AMT	0.19	0.14	enet	25	0.20	3.7e-09	-4.8	5.7	1.2e-08	-0.70	0.12	0.88	FALSE
15	GTEx	Brain Putamen basal ganglia	AMT	0.11	0.03	lasso	14	0.05	2.4e-02	-4.8	5.7	1.5e-08	-0.67	0.06	0.35	FALSE
28	GTEx	Esophagus Mucosa	GPX1	0.04	0.02	enet	18	0.02	2.0e-02	-4.9	-5.6	1.7e-08	0.81	0.10	0.82	FALSE
1	CommonMind	Brain Pre-frontal Cortex	P4HTM	0.13	0.13	blup	264	0.14	1.7e-16	-4.8	5.6	1.9e-08	-0.68	0.37	0.63	FALSE
95	The Cancer Genome Atlas	Thyroid Carcinoma	TCTA	0.04	0.04	blup	24	0.03	3.6e-04	5.2	5.6	2.0e-08	-0.80	0.01	0.94	FALSE
65	GTEx	Thyroid	TCTA	0.04	0.02	lasso	4	0.01	2.4e-02	-4.8	5.6	2.2e-08	-0.71	0.11	0.81	FALSE
29	GTEx	Esophagus Muscularis	QRICH1	0.06	0.06	lasso	10	0.05	7.7e-04	-5.2	-5.6	2.6e-08	0.61	0.11	0.88	FALSE
84	YFS	Blood	NICN1	0.15	0.20	blup	283	0.22	3.5e-70	-5.2	-5.5	3.0e-08	0.63	0.08	0.92	FALSE
75	METSIM	Adipose	QRICH1	0.05	0.09	lasso	5	0.09	9.8e-13	-5.4	-5.5	3.1e-08	0.60	0.06	0.94	FALSE
23	GTEx	Colon Transverse	AMT	0.11	0.18	lasso	7	0.18	8.7e-09	-5.2	5.5	3.6e-08	-0.65	0.08	0.92	FALSE
71	GTEx	Uterus	NICN1	0.11	0.09	lasso	3	0.07	1.6e-02	-5.2	5.5	3.9e-08	-0.56	0.07	0.44	FALSE
44	GTEx	Nerve Tibial	KLHDC8B	0.05	0.03	lasso	13	0.02	7.1e-03	-4.8	-5.5	4.5e-08	0.83	0.15	0.71	FALSE
94	The Cancer Genome Atlas	Thyroid Carcinoma	P4HTM	0.13	0.09	enet	3	0.11	6.8e-11	-5.3	5.4	5.2e-08	-0.62	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	LAMB2	0.05	0.00	lasso	5	0.00	7.0e-01	-3.8	-5.4	5.3e-08	0.80	0.07	0.61	FALSE
74	METSIM	Adipose	AMT	0.10	0.21	lasso	25	0.21	2.9e-30	-5.3	5.4	5.7e-08	-0.64	0.08	0.92	FALSE
47	GTEx	Ovary	GPX1	0.12	0.08	lasso	4	0.08	5.7e-03	-4.8	-5.4	5.8e-08	0.66	0.11	0.62	FALSE
60	GTEx	Stomach	GPX1	0.11	0.15	lasso	3	0.14	2.4e-07	-5.2	-5.4	6.2e-08	0.67	0.09	0.91	FALSE
77	ROSMAP	Brain Pre-frontal Cortex	NICN1	0.08	0.05	enet	15	0.05	1.8e-07	-5.2	-5.4	6.2e-08	0.59	0.10	0.90	FALSE
51	GTEx	Pituitary	P4HTM	0.36	0.16	lasso	4	0.08	4.2e-03	-5.2	5.4	6.4e-08	-0.51	0.11	0.70	FALSE
6	GTEx	Artery Coronary	DALRD3	0.19	0.14	lasso	2	0.12	1.1e-04	-5.4	5.4	7.4e-08	-0.60	0.10	0.86	FALSE
87	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ARIH2	0.07	0.01	lasso	3	0.02	1.9e-02	-5.2	5.4	7.6e-08	-0.54	0.01	0.76	FALSE
25	GTEx	Colon Transverse	GPX1	0.11	0.01	lasso	5	0.01	8.8e-02	-5.2	-5.4	7.7e-08	0.54	0.07	0.60	FALSE
10	GTEx	Brain Cerebellum	AMT	0.37	0.36	lasso	18	0.34	8.2e-11	-5.1	5.4	8.4e-08	-0.62	0.09	0.91	FALSE
48	GTEx	Ovary	NICN1-AS1	0.17	0.11	lasso	3	0.10	2.1e-03	-5.2	5.3	9.3e-08	-0.57	0.10	0.74	FALSE
70	GTEx	Uterus	AMT	0.24	0.19	lasso	11	0.18	1.4e-04	-5.2	5.3	9.3e-08	-0.54	0.10	0.71	FALSE
38	GTEx	Lung	P4HTM	0.09	0.10	lasso	2	0.09	2.0e-07	-5.2	5.3	9.4e-08	-0.55	0.09	0.91	FALSE
21	GTEx	Cells Transformed fibroblasts	NICN1	0.06	0.06	lasso	7	0.05	1.6e-04	-4.7	5.3	9.5e-08	-0.61	0.10	0.89	FALSE
63	GTEx	Testis	QRICH1	0.16	0.23	lasso	11	0.20	2.9e-09	-5.2	-5.3	9.5e-08	0.55	0.11	0.89	FALSE
40	GTEx	Muscle Skeletal	NICN1	0.05	0.06	lasso	1	0.06	2.7e-06	-5.3	5.3	9.8e-08	-0.61	0.08	0.91	FALSE
41	GTEx	Muscle Skeletal	NICN1-AS1	0.05	0.07	lasso	1	0.06	8.6e-07	-5.3	5.3	9.8e-08	-0.61	0.08	0.92	FALSE
78	ROSMAP	Brain Pre-frontal Cortex	P4HTM	0.04	0.06	lasso	3	0.05	4.7e-07	-5.2	5.3	9.8e-08	-0.56	0.07	0.93	FALSE
33	GTEx	Heart Left Ventricle	HYAL1	0.23	0.03	enet	26	0.12	5.8e-07	3.1	5.3	9.9e-08	-0.37	0.33	0.26	FALSE
73	GTEx	Whole Blood	GPX1	0.05	0.06	enet	15	0.05	1.5e-05	-5.2	-5.3	1.0e-07	0.71	0.08	0.92	FALSE
81	ROSMAP	Brain Pre-frontal Cortex	QRICH1	0.04	0.05	lasso	1	0.05	2.1e-07	-5.3	-5.3	1.0e-07	0.50	0.07	0.93	FALSE
3	GTEx	Adipose Subcutaneous	KLHDC8B	0.04	0.01	lasso	5	0.00	1.3e-01	-4.3	-5.3	1.2e-07	0.76	0.12	0.70	FALSE
24	GTEx	Colon Transverse	QRICH1	0.10	0.06	lasso	5	0.06	1.0e-03	-5.3	-5.3	1.2e-07	0.47	0.10	0.81	FALSE
45	GTEx	Nerve Tibial	QRICH1	0.07	0.06	lasso	6	0.08	3.0e-06	-5.1	-5.3	1.2e-07	0.61	0.13	0.87	FALSE
76	ROSMAP	Brain Pre-frontal Cortex	AMT	0.15	0.27	lasso	15	0.28	2.2e-36	-4.7	5.3	1.2e-07	-0.58	0.10	0.90	FALSE
89	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	P4HTM	0.06	0.04	blup	20	0.06	3.1e-04	-4.8	5.3	1.2e-07	-0.64	0.02	0.92	FALSE
9	GTEx	Brain Cerebellar Hemisphere	AMT	0.40	0.42	enet	23	0.42	4.1e-12	-5.2	5.3	1.3e-07	-0.61	0.10	0.90	FALSE
46	GTEx	Nerve Tibial	NCKIPSD	0.28	0.31	lasso	5	0.34	8.6e-25	-4.7	5.3	1.3e-07	-0.62	0.23	0.76	FALSE
55	GTEx	Skin Sun Exposed Lower leg	QRICH1	0.05	0.06	lasso	3	0.07	1.1e-06	-5.1	-5.3	1.3e-07	0.56	0.14	0.86	FALSE
20	GTEx	Cells Transformed fibroblasts	AMT	0.16	0.24	lasso	8	0.24	4.4e-18	-5.4	5.3	1.4e-07	-0.61	0.08	0.92	FALSE
53	GTEx	Skin Sun Exposed Lower leg	AMT	0.18	0.21	lasso	15	0.22	2.3e-18	-5.2	5.3	1.4e-07	-0.60	0.08	0.92	FALSE
57	GTEx	Skin Sun Exposed Lower leg	NICN1-AS1	0.09	0.08	lasso	7	0.06	4.6e-06	-5.2	5.3	1.4e-07	-0.63	0.08	0.92	FALSE
11	GTEx	Brain Cerebellum	QRICH1	0.15	0.15	lasso	5	0.09	1.1e-03	-5.2	-5.3	1.5e-07	0.50	0.11	0.82	FALSE
19	GTEx	Breast Mammary Tissue (Female)	QRICH1	0.18	0.16	lasso	3	0.10	5.2e-04	-4.8	-5.3	1.5e-07	0.66	0.19	0.67	FALSE
39	GTEx	Muscle Skeletal	AMT	0.21	0.11	lasso	12	0.13	1.8e-12	-5.2	5.3	1.5e-07	-0.62	0.08	0.92	FALSE
91	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC36	0.06	0.05	lasso	5	0.05	3.4e-06	-5.4	5.2	1.6e-07	-0.95	0.00	1.00	FALSE
37	GTEx	Lung	TCTA	0.09	0.01	enet	10	0.03	3.3e-03	5.2	5.2	1.8e-07	-0.44	0.05	0.31	FALSE
12	GTEx	Brain Hypothalamus	P4HTM	0.12	0.04	lasso	8	0.02	1.3e-01	-4.9	5.2	1.9e-07	-0.62	0.06	0.49	FALSE
27	GTEx	Esophagus Mucosa	AMT	0.13	0.19	lasso	9	0.18	2.5e-12	-5.2	5.2	1.9e-07	-0.61	0.09	0.91	FALSE
4	GTEx	Adipose Subcutaneous	QRICH1	0.09	0.08	lasso	5	0.08	2.3e-07	-5.1	-5.2	2.0e-07	0.47	0.10	0.90	FALSE
93	The Cancer Genome Atlas	Lung Adenocarcinoma	P4HTM	0.02	0.03	blup	20	0.03	2.4e-04	-4.8	5.2	2.0e-07	-0.67	0.03	0.88	FALSE
59	GTEx	Spleen	NCKIPSD	0.11	0.12	enet	10	0.11	7.7e-04	-4.6	5.2	2.1e-07	-0.68	0.10	0.57	FALSE
68	GTEx	Thyroid	NICN1-AS1	0.19	0.27	enet	31	0.29	1.9e-22	-5.2	5.2	2.1e-07	-0.58	0.08	0.92	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	NICN1	0.16	0.10	lasso	10	0.09	2.7e-03	-4.8	-5.2	2.2e-07	0.60	0.08	0.68	FALSE
35	GTEx	Heart Left Ventricle	NDUFAF3	0.06	0.08	lasso	13	0.04	2.0e-03	-4.9	5.2	2.2e-07	-0.67	0.22	0.75	FALSE
50	GTEx	Pituitary	ARIH2	0.19	0.13	lasso	7	0.13	3.1e-04	-4.8	5.2	2.2e-07	-0.71	0.23	0.64	FALSE
54	GTEx	Skin Sun Exposed Lower leg	NICN1	0.07	0.09	lasso	10	0.08	5.6e-07	-5.2	5.2	2.2e-07	-0.61	0.08	0.92	FALSE
67	GTEx	Thyroid	QRICH1	0.05	0.07	lasso	2	0.05	1.1e-04	-5.2	-5.2	2.2e-07	0.49	0.09	0.89	FALSE
18	GTEx	Breast Mammary Tissue	QRICH1	0.17	0.20	lasso	4	0.20	1.6e-10	-4.8	-5.2	2.3e-07	0.66	0.31	0.69	FALSE
42	GTEx	Nerve Tibial	AMT	0.20	0.32	enet	23	0.33	6.4e-24	-5.2	5.2	2.3e-07	-0.60	0.07	0.93	FALSE
82	ROSMAP	Brain Pre-frontal Cortex	BSN-AS2	0.07	0.10	lasso	6	0.09	3.5e-12	5.2	-5.2	2.3e-07	0.71	0.07	0.93	FALSE
86	The Cancer Genome Atlas	Colon Adenocarcinoma	USP4	0.06	0.04	lasso	5	0.05	5.3e-04	-4.9	-5.2	2.3e-07	0.75	0.05	0.76	FALSE
7	GTEx	Artery Tibial	TCTA	0.04	0.04	lasso	1	0.03	1.6e-03	-5.2	5.2	2.4e-07	-0.60	0.09	0.78	FALSE
79	ROSMAP	Brain Pre-frontal Cortex	FAM212A	0.07	0.02	bslmm	286	0.03	5.0e-05	5.1	-5.2	2.4e-07	0.61	0.07	0.92	FALSE
16	GTEx	Brain Putamen basal ganglia	NCKIPSD	0.23	0.23	enet	14	0.22	5.4e-06	-4.8	5.2	2.5e-07	-0.70	0.10	0.84	FALSE
17	GTEx	Breast Mammary Tissue	AMT	0.15	0.22	enet	26	0.25	3.7e-13	-4.8	5.2	2.5e-07	-0.62	0.11	0.89	FALSE
32	GTEx	Heart Atrial Appendage	RHOA-IT1	0.07	0.04	lasso	3	0.04	4.4e-03	-4.5	-5.2	2.5e-07	0.80	0.13	0.53	FALSE
8	GTEx	Brain Caudate basal ganglia	NCKIPSD	0.18	0.15	lasso	3	0.20	2.2e-06	-4.6	5.2	2.6e-07	-0.67	0.11	0.86	FALSE
43	GTEx	Nerve Tibial	CCDC71	0.10	0.06	lasso	3	0.05	1.8e-04	-5.1	-5.2	2.6e-07	0.49	0.11	0.82	FALSE
85	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMT	0.03	0.04	lasso	1	0.03	2.2e-07	-5.2	5.2	2.6e-07	-0.61	0.02	0.98	FALSE
49	GTEx	Pancreas	AMT	0.20	0.16	lasso	4	0.14	2.6e-06	-5.2	5.1	2.7e-07	-0.52	0.10	0.88	FALSE
69	GTEx	Thyroid	RHOA-IT1	0.05	0.05	lasso	5	0.04	5.2e-04	5.3	-5.1	2.8e-07	0.72	0.09	0.86	FALSE
30	GTEx	Esophagus Muscularis	NCKIPSD	0.18	0.13	lasso	6	0.17	2.4e-10	-4.6	5.1	2.9e-07	-0.67	0.16	0.83	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	AMT	0.14	0.20	lasso	5	0.22	3.0e-12	-5.2	5.1	2.9e-07	-0.60	0.09	0.91	FALSE
64	GTEx	Thyroid	AMT	0.26	0.36	enet	26	0.37	8.7e-30	-5.2	5.1	2.9e-07	-0.61	0.08	0.92	FALSE
66	GTEx	Thyroid	DALRD3	0.04	0.04	lasso	4	0.04	4.4e-04	-5.2	5.1	2.9e-07	-0.54	0.14	0.78	FALSE