TWAS hub - NDUFAF3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.0617	0.0298	0.00011	0.076	NA	0.018	NA	0.045	7.5e-05	NA	0.0350	NA	0.0020
2	GTEx	Skin Sun Exposed Lower leg	0.0310	0.0180	0.00220	0.044	NA	0.031	NA	0.024	1.5e-04	NA	0.0012	NA	0.0041
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0410	0.0360	0.00700	0.039	0.04	0.023	NA	0.040	2.6e-03	0.0025	0.0170	NA	0.0023

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Pulse rate, automated reading	21.3	68.8	74.1	8.6	8.0	8.3
Pulse rate	14.3	24.1	26.8	5.2	4.7	4.8
Blood Eosinophil Count	12.6	96.8	102.5	10.1	9.3	10.1
Frequency of tiredness / lethargy in last 2 weeks	12.3	20.0	22.2	-4.7	-4.3	-4.4
Irritability	11.6	19.6	21.4	-4.5	-4.1	-4.6
Number of full sisters	11.5	13.9	14.8	-3.6	-3.7	-3.9
Impedance of arm (left)	11.1	51.6	54.6	7.4	6.8	7.3
Illnesses of siblings	10.4	14.6	15.6	3.8	3.7	3.9
Pack years of smoking	10.1	14.9	15.4	-3.9	-3.9	-3.8
Pack years adult smoking proportion	10.0	15.3	16.7	-4.1	-3.8	-3.8
Heel T-Score	9.3	74.4	75.0	8.7	8.6	8.6
Heel bone mineral density (BMD) T-score, automated (right)	9.0	20.6	21.9	4.7	4.4	4.5
Ever depressed for a whole week	8.7	10.8	11.7	-3.4	-3.1	-3.3
Hypothyroidism (self reported)	8.6	19.6	20.9	-4.5	-4.3	-4.6
Number of full brothers	8.6	10.8	12.2	-3.5	-2.9	-3.4
Hypothyroidism/myxoedema (self-reported)	8.4	16.5	18.3	-4.0	-3.9	-4.3
Waist Hip Ratio (WHR)	8.3	37.4	45.3	6.7	6.0	5.6
Impedance of arm (right)	8.2	38.4	40.7	6.4	5.9	6.3
Impedance of whole body	7.3	37.0	40.3	6.3	5.8	6.1
Heel bone mineral density (BMD) T-score, automated (left)	6.6	15.1	16.2	4.0	3.8	3.8
Medication: Levothyroxine sodium	6.6	11.2	12.3	-3.4	-3.2	-3.5
Pain all over the body in last month	6.4	6.8	8.4	-2.9	-2.3	-2.6
Height	6.1	118.3	130.0	11.4	10.4	10.8
Sitting height	5.7	40.5	42.3	6.5	6.4	6.2
Ever unenthusiastic/disinterested for a whole week	5.6	6.9	8.1	-2.9	-2.3	-2.6
Townsend deprivation index at recruitment	5.2	7.3	8.9	-2.7	-2.4	-3.0
Frequency of tenseness / restlessness in last 2 weeks	5.2	8.1	9.3	-3.1	-2.8	-2.6
Smoking Status	5.1	12.2	15.3	-3.9	-3.1	-3.5
Standing height	5.1	50.9	56.2	7.5	6.9	7.0
Ever had bowel cancer screening	4.9	5.7	6.6	-2.3	-2.6	-2.3
Illnesses of siblings: Diabetes	4.8	6.0	6.2	-2.5	-2.5	-2.3
Commuting to job workplace: Cycle	4.7	5.7	6.3	2.5	2.1	2.5
Heart disease (siblings)	4.7	5.8	6.3	-2.4	-2.3	-2.5
Systolic blood pressure, automated reading	4.5	13.1	13.7	-3.6	-3.6	-3.7
Trunk fat percentage	4.5	18.2	19.5	4.0	4.4	4.4
Hypertension (Self-reported)	4.5	12.5	14.8	-3.1	-3.8	-3.6
Bipolar Disorder (2011)	4.4	4.3	4.8	-2.0	-2.2	-2.0
Crohns Disease (2012)	4.3	6.9	8.4	-2.1	-2.9	-2.8
Age at first live birth	4.3	7.7	9.1	3.0	2.2	3.0
Tense / ‘highly strung’	4.1	6.8	8.2	-2.9	-2.2	-2.7
Mother’s age at death	4.1	5.1	5.6	2.4	2.1	2.3
High blood pressure	3.9	10.7	12.8	-2.9	-3.6	-3.3
Ever had prostate specific antigen (PSA) test	3.8	4.3	4.5	2.1	2.1	2.1
Average weekly spirits intake	3.7	4.5	5.9	1.8	2.1	2.4
Vascular/heart problems diagnosed by doctor	3.7	10.1	11.8	2.8	3.4	3.2
Schizophrenia (2018)	3.5	7.2	8.2	-2.4	-2.9	-2.8
Trunk fat mass	3.5	15.1	16.4	3.6	4.0	4.0
Medication: Ramipril	3.5	4.6	5.3	-2.0	-2.3	-2.1
Happiness	3.5	4.3	5.2	-1.9	-2.3	-2.0
Miserableness	3.4	5.9	7.8	-2.8	-2.1	-2.3
Major Depression (MDD)	3.3	4.0	4.5	-2.0	-1.8	-2.1
Serious illness, injury or assault to yourself	3.3	4.0	4.2	-2.1	-2.0	-2.0
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	4.2	-2.0	-1.9	-1.9
Unable to work because of sickness or disability	3.3	4.3	4.8	-2.2	-1.9	-2.2
Hand grip strength (right)	3.2	8.6	10.1	2.8	2.8	3.2
Diverticular disease/diverticulitis (self-reported)	3.2	3.8	4.8	-2.2	-1.7	-1.9
Schizophrenia (2014)	3.1	6.8	7.9	-2.4	-2.8	-2.6
Qualifications: NVQ or HND or HNC or equivalent	3.1	3.7	4.2	1.9	1.8	2.0
Bipolar Disorder or Schizophrenia	3.0	7.3	8.6	-2.5	-2.9	-2.6
Medication: Co-codamol	3.0	3.4	4.7	-2.2	-1.5	-1.9
Had other major operations	3.0	3.6	4.1	-2.0	-1.7	-2.0
Alcohol intake versus 10 years previously	3.0	4.5	6.5	1.9	2.6	1.8
Age when periods started (menarche)	2.9	6.9	8.5	-2.9	-2.3	-2.6
Medication: Allopurinol	2.9	3.9	4.4	2.1	1.9	1.9
HbA1C	2.8	3.1	3.8	2.0	1.7	1.5
Breastfed as a baby	2.7	3.3	4.4	1.6	1.7	2.1
Fractured/broken bones in last 5 years	2.7	3.5	4.0	-1.8	-2.0	-1.8
Cardiovascular Disease	2.6	8.5	10.0	-2.5	-3.2	-3.0
Stomach or abdominal pain in last month	2.6	3.3	3.8	-2.0	-1.6	-1.9
Wheeze or whistling in the chest in last year	2.6	4.6	5.4	1.8	2.3	2.2
Depressed Affect (Nagel 2018)	2.5	5.2	6.7	-2.6	-2.1	-2.2
Prostate Cancer	2.5	3.6	4.3	-2.1	-1.9	-1.7
Other serious medical condition/disability diagnosed by doctor	2.5	3.2	4.1	-1.5	-2.0	-1.8
Current tobacco smoking	2.5	4.0	5.7	-2.4	-1.6	-2.0
Medication for pain relief, constipation, heartburn	2.5	4.3	4.5	2.1	2.0	2.1
Mood swings	2.5	4.6	5.3	-2.3	-1.9	-2.2
Medication: Paracetamol	2.4	4.1	5.2	-2.3	-1.7	-2.0
Had major operations	2.4	2.8	3.4	-1.8	-1.5	-1.6
Hand grip strength (left)	2.3	6.1	7.9	2.3	2.2	2.8
Vitamin and mineral supplements	2.3	3.1	3.6	1.9	1.4	1.9
Lung cancer (father)	2.3	2.7	3.0	-1.7	-1.7	-1.5
Ever highly irritable/argumentative for 2 days	2.3	2.7	3.5	-1.9	-1.3	-1.7
Medication: Ventolin 100micrograms inhaler	2.3	3.0	3.2	1.7	1.7	1.8
Comparative height size at age 10	2.3	12.9	13.5	3.7	3.5	3.6
Age at last live birth	2.3	3.3	4.0	2.0	1.5	1.9
Neuroticism	2.2	5.3	6.3	-2.5	-2.0	-2.4
Body fat percentage	2.2	8.6	9.6	2.6	3.1	3.1
Number of self-reported non-cancer illnesses	2.2	3.7	3.9	-2.0	-1.9	-1.9
Financial situation satisfaction	2.2	2.7	2.8	-1.7	-1.6	-1.6
Medication: Paracetamol	2.2	3.4	4.7	-2.2	-1.5	-1.8
Number of operations (self-reported)	2.2	3.3	4.3	-2.1	-1.5	-1.8
Triglycerides	2.1	3.5	4.0	1.9	2.0	1.7
Qualifications: None of the above	2.1	4.5	6.6	-2.6	-1.5	-2.2
Depression (self-reported)	2.1	2.5	2.8	-1.7	-1.6	-1.4
Pulse wave Arterial Stiffness index	2.1	2.4	2.5	1.5	1.6	1.6
Mean time to correctly identify matches	2.1	4.0	4.1	-2.0	-2.0	-2.0
Supplements: Zinc	2.0	2.2	2.9	-1.4	-1.7	-1.3
Number of incorrect matches in round	2.0	3.3	4.1	-2.0	-1.8	-1.6
Forced vital capacity (FVC), Best measure	2.0	7.4	9.4	3.1	2.5	2.6
Chest pain or discomfort	2.0	2.8	3.7	-1.9	-1.3	-1.8
Osteoporosis (self-reported)	2.0	2.4	2.9	-1.7	-1.7	-1.3
Neuroticism (Nagel 2018)	1.9	4.6	5.7	-2.4	-1.8	-2.2
Systolic Blood Pressure	1.9	9.5	10.3	-2.8	-3.2	-3.2
Relative age voice broke	1.9	2.8	3.4	-1.9	-1.5	-1.7
Whole body fat mass	1.9	8.1	9.4	2.5	3.1	2.9
Illness, injury, bereavement, stress in last 2 years	1.9	2.4	2.8	1.5	1.4	1.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	2.4	-1.4	-1.6	-1.4
Asthma (self-reported)	1.9	3.8	4.2	1.9	1.9	2.1
Qualifications: CSEs or equivalent	1.8	2.3	3.1	-1.8	-1.1	-1.6
Impedance of leg (left)	1.8	8.9	10.6	3.2	2.9	2.8
High blood pressure (siblings)	1.8	2.5	3.0	-1.6	-1.4	-1.7
Loneliness, isolation	1.8	2.5	3.0	-1.7	-1.5	-1.5
Breast cancer (self-reported)	1.8	2.1	2.5	1.4	1.4	1.6
Average weekly beer plus cider intake	1.8	2.6	3.9	1.2	2.0	1.5
Impedance of leg (right)	1.7	8.2	9.4	3.1	2.8	2.7
Osteoarthritis (self-reported)	1.7	2.2	2.9	-1.7	-1.1	-1.5
Smoking status: Current	1.7	2.7	4.0	-2.0	-1.2	-1.7
Commuting to job workplace: Public transport	1.7	2.0	2.4	1.4	1.3	1.5
Medication: Blood pressure	1.7	3.1	5.0	-1.3	-2.2	-1.7
Rheumatoid Arthritis	1.6	2.2	2.9	-1.4	-1.3	-1.7
Forced vital capacity (FVC)	1.6	6.1	8.0	2.8	2.3	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	4.9	6.8	2.6	2.0	2.0
Eye problems/disorders: Glaucoma	1.6	1.9	2.5	-1.1	-1.4	-1.6
Reaction Time	1.5	2.8	3.0	-1.7	-1.6	-1.7
Severe depression (siblings)	1.5	1.7	2.0	-1.3	-1.4	-1.2
Heart attack	1.5	1.9	2.4	-1.4	-1.2	-1.5
Number of live births	1.5	2.2	3.0	1.3	1.7	1.3
Asthma	1.5	3.0	3.4	1.7	1.7	1.8
Gout (self-reported)	1.5	2.1	2.3	1.5	1.5	1.3
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	2.3	1.4	1.0	1.5
Neck or shoulder pain in last month	1.5	2.2	2.6	-1.6	-1.3	-1.5
Illnesses of father: None of the above (group 1)	1.5	1.9	2.3	1.3	1.5	1.3
Age at First Birth	1.4	2.0	2.4	1.6	1.3	1.4
Chronotype (morning person)	1.4	3.3	4.2	2.0	1.6	1.8
Frequency of depressed mood in last 2 weeks	1.4	1.9	2.2	-1.5	-1.4	-1.2
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	6.9	2.6	2.0	1.9
Prospective memory result	1.4	1.7	2.1	1.1	1.4	1.4
Length of working week for main job	1.4	1.5	2.2	-1.2	-0.9	-1.5
Arm fat percentage (left)	1.4	5.7	6.7	2.0	2.5	2.6
Wears glasses or contact lenses	1.4	1.6	2.0	1.3	1.0	1.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	2.0	-1.4	-1.2	-1.3
Neuroticism score	1.3	2.7	3.4	-1.8	-1.2	-1.8
Medication: Ibuprofen	1.3	1.6	1.7	-1.3	-1.2	-1.3
Medication: Seretide 50 evohaler	1.3	1.5	2.0	1.1	1.2	1.4
Heart attack/myocardial infarction (self-reported)	1.3	1.6	2.0	-1.3	-1.1	-1.4
Coronary Artery Disease (CAD)	1.2	1.4	2.1	1.0	1.1	1.5
Multivitamins +/- minerals	1.2	1.5	1.9	-1.4	-1.0	-1.3
High blood pressure (mother)	1.2	1.7	2.1	-1.0	-1.4	-1.4
Peak expiratory flow (PEF)	1.2	2.8	3.5	-1.3	-1.9	-1.8
Illnesses of father: Heart disease	1.2	1.6	2.0	-1.3	-1.1	-1.4
Diabetes diagnosed by doctor	1.2	2.0	3.1	1.8	1.1	1.3
HDL Cholesterol	1.1	1.8	2.1	-1.4	-1.3	-1.3
Fed-up feelings	1.1	1.9	3.2	-1.8	-1.0	-1.3
Financial difficulties in last 2 years	1.1	1.5	1.9	-1.3	-1.0	-1.4
Weight	1.1	5.2	6.0	2.1	2.5	2.3
Noisy workplace	1.1	1.4	2.0	-1.4	-0.5	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.7	2.3	-1.5	-1.1	-1.2
Pulse wave reflection index	1.1	1.4	1.8	-1.3	-1.0	-1.1
Pulse wave peak to peak time	1.1	1.3	1.5	-1.1	-1.2	-1.2
Arm fat mass (left)	1.1	4.6	5.6	1.8	2.4	2.3
Blood Red Count	1.0	10.1	12.3	3.5	3.0	3.0
Waist circumference	1.0	3.8	4.0	2.0	2.0	1.9
Allergy	1.0	2.4	3.1	-1.5	-1.4	-1.8
Fluid intelligence score	1.0	2.2	3.7	-1.1	-1.9	-1.3
Ever smoked	1.0	1.7	2.6	-1.6	-0.8	-1.4
Alzheimer’s Disease (including proxy)	0.9	1.3	1.7	1.2	0.8	1.3
Ovarian Cancer	0.9	1.2	1.7	-1.3	-1.1	-0.8
Hearing difficulty/problems: Yes	0.9	1.4	1.6	1.2	1.0	1.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	1.6	1.0	1.2	0.9
Diabetes (self-reported)	0.9	1.5	2.4	1.5	0.9	1.1
Time employed in main current job	0.9	1.0	1.1	-1.0	-1.0	-1.0
Father’s age at death	0.9	1.2	2.1	1.5	0.6	1.1
Glaucoma (self-reported)	0.9	1.0	1.5	-0.6	-1.2	-1.1
Medication: Omeprazole	0.9	1.1	1.5	-1.2	-0.8	-1.1
Age started oral contraceptive pill	0.9	1.1	1.3	1.1	0.9	1.1
Pain experienced in last month	0.9	1.5	2.0	1.4	0.9	1.2
Crohns Disease (2017)	0.8	1.8	2.5	-0.8	-1.5	-1.6
Relative age of first facial hair	0.8	1.7	2.0	-1.4	-1.3	-1.2
Medication for hormone replacement therapy	0.8	0.9	1.3	0.7	1.1	0.9
Medication: Metformin	0.8	1.1	1.6	1.3	0.9	0.9
Leg fat-free mass (left)	0.8	4.4	5.3	1.9	2.3	2.1
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.1	-1.0	-0.9	-1.0
Exposure to tobacco smoke at home	0.8	0.9	1.0	-1.0	-0.9	-0.9
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	1.6	-1.3	-1.0	-1.1
Worry too long after embarrassment	0.8	1.4	1.8	1.4	1.2	0.9
Family relationship satisfaction	0.8	1.0	1.2	-1.0	-1.1	-0.9
Knee pain experienced in last month	0.8	1.2	1.6	-1.2	-0.9	-1.2
Diastolic blood pressure, automated reading	0.8	2.6	2.6	-1.6	-1.6	-1.6
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.0	0.8	1.0	0.9
Maternal smoking around birth	0.7	1.1	1.7	-1.0	-0.7	-1.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.9	1.4	0.7	1.2	0.8
Leg predicted mass (left)	0.7	3.9	4.6	1.8	2.1	2.0
Arm fat percentage (right)	0.7	2.8	3.5	1.3	1.8	1.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.0	-0.7	-1.7	-1.2
Arm fat mass (right)	0.7	3.0	3.6	1.4	1.9	1.9
Loud music exposure frequency	0.7	0.7	1.3	-0.7	-0.6	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.8	1.0	-1.0	-1.0	-0.7
Medication: Aspirin	0.7	0.9	1.1	-0.7	-1.1	-1.0
Supplements: Vitamin C	0.7	0.8	1.0	0.8	1.0	0.9
Eye problems/disorders: Cataract	0.7	0.8	1.4	-0.6	-1.2	-0.8
Leg predicted mass (right)	0.7	3.6	4.0	1.8	2.0	1.9
Bipolar Disorder (2018)	0.6	1.0	1.3	-1.0	-1.1	-0.7
Ulcerative Colitis (UC)	0.6	1.1	2.5	1.6	0.7	0.5
Lupus	0.6	0.9	1.5	-0.8	-1.2	-0.8
Past tobacco smoking	0.6	1.1	1.5	1.2	0.6	1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.6	1.2	1.0	1.2
Leg fat-free mass (right)	0.6	3.4	3.9	1.7	2.0	1.8
Supplements: Calcium	0.6	0.7	0.8	-0.9	-0.8	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	1.2	-0.7	-1.1	-0.8
Alcohol drinker status: Previous	0.6	0.7	0.8	-0.9	-0.9	-0.6
Primary Biliary Cirrhosis	0.5	0.6	0.9	-0.8	-1.0	-0.6
Diabetes (mother)	0.5	0.6	0.8	0.8	0.9	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.0	1.6	0.8	0.8	1.3
Alcohol usually taken with meals	0.5	0.7	0.9	0.9	0.7	0.9
Worrier / anxious feelings	0.5	1.0	1.2	-1.1	-1.0	-0.9
Medication: Cholesterol lowering	0.5	0.8	1.1	1.0	0.8	0.8
Birth weight of first child	0.5	0.8	1.0	1.0	0.8	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	0.9	-0.5	-0.8	-1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	0.9	-0.5	-0.9	-0.9
Overall health rating	0.5	1.1	1.8	-1.4	-0.6	-1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.1	0.5	1.0	0.6
Medication: Lisinopril	0.5	0.6	1.1	-0.6	-1.1	-0.6
Depression (Nagel 2018)	0.4	0.6	0.8	-0.8	-0.9	-0.7
Worry (Nagel 2018)	0.4	0.9	1.1	-1.0	-0.9	-1.0
Alzheimer’s Disease (in mother)	0.4	0.5	0.6	0.8	0.4	0.8
Lung FEV1/FVC ratio	0.4	1.8	2.7	1.6	1.1	1.2
Ever had hysterectomy (womb removed)	0.4	0.4	0.6	0.4	0.8	0.6
Taking other prescription medications	0.4	0.6	1.0	-1.0	-0.7	-0.6
Hair/balding pattern: Pattern 3	0.4	0.5	0.9	0.6	0.6	1.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.0	1.0	0.5	0.7
Number of children fathered	0.4	0.4	0.6	-0.8	-0.6	-0.5
Heart disease (mother)	0.4	0.5	0.6	-0.7	-0.6	-0.8
Leg fat mass (right)	0.4	1.4	2.1	0.8	1.5	1.2
Long-standing illness, disability or infirmity	0.4	0.7	0.9	-0.5	-0.9	-0.9
Friendships satisfaction	0.4	0.5	0.8	-0.6	-0.9	-0.6
Mineral and other dietary supplements	0.4	0.5	0.6	0.7	0.8	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	1.3	1.1	0.7	1.0
Ever taken oral contraceptive pill	0.4	0.4	0.6	-0.8	-0.4	-0.8
Hearing aid user	0.4	0.5	0.7	0.8	0.3	0.7
Medication: Bendroflumethiazide	0.4	0.6	1.1	-0.5	-1.0	-0.6
Leg fat mass (left)	0.4	1.5	2.1	0.9	1.5	1.3
LDL Cholesterol	0.3	0.5	0.5	0.7	0.7	0.6
Neuroticism (2016)	0.3	0.4	1.0	-1.0	-0.5	-0.3
Respiratory disease	0.3	0.8	1.0	0.9	0.7	1.0
Type 2 Diabetes (T2D) (2018)	0.3	0.6	1.1	1.1	0.6	0.7
Angina	0.3	0.4	0.5	0.6	0.7	0.5
Average weekly fortified wine intake	0.3	0.4	0.7	0.6	0.3	0.8
Medication: Simvastatin	0.3	0.5	0.8	0.9	0.5	0.7
Exposure to tobacco smoke outside home	0.3	0.4	0.7	-0.8	-0.3	-0.6
Emphysema/chronic bronchitis	0.3	0.3	0.5	-0.6	-0.5	-0.7
Leg pain on walking	0.3	0.4	0.7	-0.7	-0.2	-0.8
Average weekly red wine intake	0.3	0.5	0.6	0.7	0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.3	0.4	-0.5	-0.6	-0.6
Basal metabolic rate	0.3	1.7	2.1	1.2	1.5	1.2
Intelligence (Savage-Jansen 2018)	0.2	0.7	1.4	0.3	-1.2	-0.7
Alzheimer’s Disease (in father)	0.2	0.3	0.3	0.5	0.4	0.6
Irritable Bowel Disease (IBD)	0.2	0.4	0.6	0.5	-0.5	-0.8
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.9	-0.1	-1.0	-0.5
Mean Putamen Volume	0.2	0.2	0.4	0.6	0.2	0.4
Number of treatments/medications taken	0.2	0.3	0.4	-0.6	-0.6	-0.4
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.3	0.4	0.5
Body mass index (BMI)	0.2	0.7	1.3	-1.1	-0.5	-0.7
Nervous feelings	0.2	0.4	0.5	0.7	0.7	0.5
Hearing difficulty/problems with background noise	0.2	0.4	0.7	0.7	0.2	0.8
Falls in the last year	0.2	0.2	0.5	-0.4	-0.2	-0.7
Qualifications: College or University degree	0.2	0.6	1.5	0.3	-1.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.3	0.5	0.6	0.4
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.3	-0.5	0.1	-0.6
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	0.6	0.5	0.4
Qualifications: nursing, teaching	0.2	0.3	0.5	-0.3	-0.7	-0.5
Medication: Aspirin	0.2	0.3	0.5	-0.2	-0.7	-0.6
High cholesterol (Self-reported)	0.2	0.3	0.5	0.7	0.1	0.6
Illnesses of father: High blood pressure	0.2	0.2	0.5	0.0	-0.7	-0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	-0.3	-0.8	-0.3
Schizophrenia vs Biploar Disorder	0.1	0.1	0.2	-0.1	-0.4	-0.3
Breast Cancer	0.1	0.2	0.2	-0.3	-0.5	-0.5
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.5	-0.3	-0.3
Fasting Glucose	0.1	0.1	0.1	0.3	0.4	0.4
Ulcerative Colitis	0.1	0.2	0.3	0.4	-0.5	-0.1
Blood Platelet Count	0.1	1.1	1.8	1.4	0.8	1.0
Blood White Count	0.1	0.9	1.2	0.5	1.1	1.1
Allergy or Eczema	0.1	0.3	0.6	0.4	0.3	0.8
Hair Pigment	0.1	3.6	4.3	-2.1	-1.6	-2.0
Sensitivity / hurt feelings	0.1	0.1	0.2	0.3	0.5	-0.2
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.4	0.1	0.2
Hair/balding pattern: Pattern 2	0.1	0.1	0.2	-0.2	0.1	-0.4
Had menopause	0.1	0.1	0.4	-0.1	-0.6	-0.2
Hip circumference	0.1	0.3	0.7	-0.8	-0.4	-0.5
Medication: Lansoprazole	0.1	0.2	0.4	0.2	0.6	0.2
Illnesses of mother	0.1	0.1	0.2	-0.4	0.1	0.0
Blood clot in the leg (DVT)	0.1	0.2	0.3	-0.3	-0.6	-0.3
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.1	-0.4	-0.0	-0.4
Health satisfaction	0.1	0.1	0.2	-0.4	-0.4	-0.3
Shortness of breath walking on level ground	0.1	0.1	0.3	0.3	0.5	0.2
Eye problems/disorders: None of the above	0.1	0.2	0.4	-0.2	0.6	0.2
Medication: Blood pressure	0.1	0.2	0.2	-0.3	-0.5	-0.4
Angina (self-reported)	0.1	0.1	0.2	0.3	0.4	0.2
Arm predicted mass (right)	0.1	0.5	0.8	0.6	0.9	0.6
Alcohol intake frequency.	0.1	0.2	0.2	0.4	0.5	0.3
Suffer from ‘nerves’	0.1	0.1	0.2	-0.5	-0.4	-0.2
Whole body fat-free mass	0.1	0.8	1.0	0.8	1.0	0.8
Medication for cholesterol	0.1	0.1	0.2	-0.4	-0.0	-0.3
Whole body water mass	0.1	0.7	1.0	0.7	1.0	0.7
Average weekly champagne plus white wine intake	0.1	0.2	0.2	0.5	-0.2	0.5
Guilty feelings	0.1	0.1	0.1	-0.3	0.4	-0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.4	0.1	0.2
Pain type(s) experienced in last month: Hip pain	0.1	0.1	0.2	0.3	0.5	0.3
Alcohol drinker status: Never	0.1	0.1	0.2	0.4	0.1	0.3
Risk taking	0.1	0.1	0.3	-0.3	-0.5	-0.3
BMI	0.0	0.2	0.4	-0.4	0.6	0.2
Lung FVC	0.0	0.1	0.1	0.3	-0.2	-0.2
Tanning	0.0	0.1	0.4	-0.1	0.6	0.0
Diabetes (father)	0.0	0.0	0.1	0.4	0.1	-0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.0	0.2	0.2
Supplements: Glucosamine	0.0	0.0	0.1	-0.2	-0.2	-0.0
Medication: Atenolol	0.0	0.0	0.0	-0.2	0.1	-0.1
Chronic bronchitis/emphysema (father)	0.0	0.1	0.1	0.0	0.3	0.2
Mouth/teeth dental problems	0.0	0.0	0.0	-0.1	0.0	0.0
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.1	-0.2	-0.1	-0.0
Trunk fat-free mass	0.0	0.1	0.1	0.2	0.3	0.1
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	-0.0	0.2	0.3
Trunk predicted mass	0.0	0.1	0.1	0.2	0.3	0.1
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	0.1	0.2	-0.0
Headache pain in last month	0.0	0.1	0.1	-0.3	-0.0	-0.3
Medication: Amlodipine	0.0	0.1	0.1	0.0	-0.3	-0.3
Birth weight	0.0	0.0	0.1	-0.1	-0.3	0.2
Leg fat percentage (right)	0.0	0.1	0.2	-0.4	0.2	0.1
Arm fat-free mass (right)	0.0	0.2	0.4	0.4	0.7	0.3
Comparative body size at age 10	0.0	0.0	0.0	-0.2	-0.0	-0.0
Migraine (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1
Smoking status: Previous	0.0	0.0	0.1	0.1	0.4	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.0	0.0	0.0	-0.1	-0.0	-0.1
Commuting to job workplace: Walk	0.0	0.1	0.1	-0.1	-0.4	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.3	-0.1	-0.2
Back pain experienced in last month	0.0	0.1	0.1	0.1	0.3	0.2
Medication: Gliclazide	0.0	0.0	0.1	0.2	0.0	0.2
Medication: Atorvastatin	0.0	0.0	0.1	0.1	-0.2	-0.1
Leg fat percentage (left)	0.0	0.1	0.1	-0.2	0.3	0.2
Arm fat-free mass (left)	0.0	0.1	0.1	-0.4	-0.1	-0.4
Myopia	0.0	0.0	0.0	0.0	-0.0	0.2
Cholesterol lowering medication	0.0	0.0	0.1	0.2	-0.2	0.0
Arm predicted mass (left)	0.0	0.0	0.1	-0.2	0.0	-0.3

Hub : Genes

NDUFAF3

Models

Trait associations