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chr17:44,788,310-47,357,969

Best TWAS P=5.75e-12 · Best GWAS P=8.26e-12 conditioned to 0.349

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HOXB3	0.10	0.06	lasso	4	0.04	6.8e-04	-5.8	5.8	7.7e-09	-0.78	0.27	0.48	FALSE
2	GTEx	Adipose Subcutaneous	HOXB2	0.17	0.18	lasso	9	0.16	5.7e-13	-6.0	6.0	1.7e-09	-0.76	0.23	0.77	FALSE
3	GTEx	Adipose Subcutaneous	HOXB-AS1	0.14	0.08	lasso	7	0.08	7.9e-07	-6.0	5.9	3.9e-09	-0.76	0.21	0.79	FALSE
4	GTEx	Adipose Subcutaneous	LRRC37A2	0.34	0.52	lasso	4	0.52	1.2e-49	-5.9	-5.9	3.5e-09	0.10	0.01	0.99	FALSE
5	GTEx	Adipose Visceral Omentum	HOXB2	0.12	0.16	lasso	3	0.17	3.6e-09	-6.0	6.0	1.5e-09	-0.75	0.18	0.81	FALSE
6	GTEx	Adipose Visceral Omentum	LRRC37A2	0.32	0.48	lasso	5	0.50	2.9e-29	-5.8	-5.8	5.9e-09	0.11	0.01	0.99	FALSE
7	GTEx	Adrenal Gland	LRRC37A2	0.47	0.50	enet	30	0.54	5.9e-23	-5.8	-5.2	1.6e-07	0.13	0.01	0.99	FALSE
8	GTEx	Artery Aorta	LRRC37A2	0.31	0.44	lasso	3	0.44	4.8e-26	-5.8	-5.9	4.7e-09	0.10	0.01	0.99	FALSE
9	GTEx	Artery Coronary	WNT3	0.13	0.04	lasso	3	0.02	9.4e-02	-5.6	-5.5	2.9e-08	0.11	0.02	0.92	FALSE
10	GTEx	Artery Coronary	HOXB2	0.16	0.00	enet	25	0.05	1.0e-02	-6.0	5.1	3.1e-07	-0.76	0.04	0.84	FALSE
11	GTEx	Artery Coronary	LRRC37A2	0.38	0.48	lasso	13	0.48	5.5e-18	-5.9	-5.8	5.2e-09	0.10	0.01	0.99	FALSE
12	GTEx	Artery Tibial	LRRC37A2	0.25	0.41	lasso	8	0.40	1.2e-33	-5.9	-5.9	3.4e-09	0.10	0.01	0.99	FALSE
13	GTEx	Brain Caudate basal ganglia	LRRC37A2	0.44	0.62	enet	34	0.68	1.2e-25	-5.6	-5.8	5.8e-09	0.11	0.01	0.99	FALSE
14	GTEx	Brain Cerebellar Hemisphere	LRRC37A2	0.48	0.60	lasso	11	0.58	3.2e-18	-5.9	-5.9	4.5e-09	0.10	0.01	0.99	FALSE
15	GTEx	Brain Cerebellum	LRRC37A2	0.54	0.67	enet	23	0.69	3.2e-27	-5.9	-5.8	6.5e-09	0.11	0.01	0.99	FALSE
16	GTEx	Brain Cortex	LRRC37A2	0.46	0.50	enet	19	0.56	1.2e-18	-5.8	-5.6	2.0e-08	0.12	0.01	0.99	FALSE
17	GTEx	Brain Frontal Cortex BA9	LRRC37A2	0.45	0.50	lasso	8	0.59	3.1e-19	-5.9	-5.7	1.3e-08	0.12	0.01	0.99	FALSE
18	GTEx	Brain Hippocampus	LRRC37A2	0.44	0.56	lasso	9	0.58	1.1e-16	-5.9	-5.8	5.1e-09	0.10	0.01	0.99	FALSE
19	GTEx	Brain Hypothalamus	LRRC37A2	0.56	0.59	lasso	8	0.62	1.9e-18	-5.9	-5.7	1.1e-08	0.12	0.01	0.99	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	LRRC37A2	0.46	0.62	lasso	11	0.66	3.4e-23	-5.9	-5.8	7.0e-09	0.12	0.01	0.99	FALSE
21	GTEx	Brain Putamen basal ganglia	LRRC37A2	0.41	0.62	lasso	12	0.62	1.6e-18	-5.9	-5.9	4.4e-09	0.11	0.01	0.99	FALSE
22	GTEx	Breast Mammary Tissue	LRRC37A2	0.38	0.44	lasso	2	0.44	8.3e-25	-5.9	-5.9	3.7e-09	0.10	0.01	0.99	FALSE
23	GTEx	Breast Mammary Tissue (Male)	LRRC37A2	0.37	0.24	lasso	5	0.18	6.3e-05	-5.9	-5.7	1.1e-08	0.11	0.01	0.98	FALSE
24	GTEx	Breast Mammary Tissue (Female)	LRRC37A2	0.24	0.24	lasso	5	0.23	1.8e-07	-5.9	-5.9	3.2e-09	0.10	0.01	0.99	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	NSF	0.20	0.07	lasso	2	0.10	3.4e-04	4.0	-5.6	2.5e-08	0.02	0.02	0.82	FALSE
26	GTEx	Cells Transformed fibroblasts	HOXB2	0.19	0.21	enet	12	0.21	5.5e-16	-5.9	6.4	1.5e-10	-0.74	0.25	0.75	FALSE
27	GTEx	Colon Sigmoid	LRRC37A2	0.42	0.63	lasso	14	0.64	1.1e-28	-5.6	-5.9	3.9e-09	0.10	0.01	0.99	FALSE
28	GTEx	Colon Transverse	LRRC37A2	0.37	0.41	enet	26	0.40	1.4e-20	-5.9	-5.9	3.0e-09	0.11	0.01	0.99	FALSE
29	GTEx	Esophagus Gastroesophageal Junction	HOXB2	0.14	0.19	lasso	3	0.17	1.2e-06	-6.0	5.8	5.7e-09	-0.69	0.20	0.73	FALSE
30	GTEx	Esophagus Gastroesophageal Junction	LRRC37A2	0.38	0.49	enet	19	0.50	1.4e-20	-5.9	-6.3	3.6e-10	0.10	0.01	0.99	FALSE
31	GTEx	Esophagus Mucosa	LRRC37A2	0.24	0.17	lasso	9	0.22	4.9e-15	-5.9	-5.5	4.4e-08	0.13	0.01	0.99	FALSE
32	GTEx	Esophagus Mucosa	LRRC37A17P	0.14	0.12	lasso	4	0.12	1.6e-08	-5.9	5.9	3.9e-09	-0.10	0.01	0.99	FALSE
33	GTEx	Esophagus Muscularis	HOXB2	0.09	0.04	lasso	7	0.06	1.4e-04	-6.0	5.2	2.0e-07	-0.55	0.23	0.61	FALSE
34	GTEx	Esophagus Muscularis	LRRC37A2	0.31	0.51	enet	22	0.51	4.5e-35	-5.9	-6.0	2.2e-09	0.11	0.01	0.99	FALSE
35	GTEx	Heart Atrial Appendage	WNT3	0.20	0.15	lasso	3	0.13	2.3e-06	-5.1	-5.5	3.6e-08	0.13	0.09	0.91	FALSE
36	GTEx	Heart Atrial Appendage	LRRC37A2	0.35	0.43	lasso	10	0.42	1.6e-20	-5.9	-5.9	4.4e-09	0.10	0.01	0.99	FALSE
37	GTEx	Heart Left Ventricle	LRRC37A2	0.23	0.38	enet	12	0.38	5.0e-21	-5.8	-5.9	4.1e-09	0.10	0.01	0.99	FALSE
38	GTEx	Liver	LRRC37A2	0.42	0.36	lasso	6	0.36	8.4e-11	-5.9	-5.7	9.2e-09	0.10	0.01	0.99	FALSE
39	GTEx	Lung	HOXB2	0.18	0.15	enet	19	0.16	5.6e-12	-6.0	5.3	1.3e-07	-0.55	0.25	0.75	FALSE
40	GTEx	Lung	HOXB-AS1	0.07	0.04	lasso	6	0.05	1.6e-04	-5.8	6.2	6.4e-10	-0.71	0.29	0.66	FALSE
41	GTEx	Lung	LRRC37A2	0.30	0.43	lasso	2	0.43	2.2e-35	-5.9	-5.9	3.2e-09	0.10	0.01	0.99	FALSE
42	GTEx	Muscle Skeletal	HOXB2	0.16	0.07	lasso	9	0.08	3.4e-08	-5.9	6.2	7.2e-10	-0.74	0.28	0.72	FALSE
43	GTEx	Nerve Tibial	HOXB2	0.09	0.08	lasso	7	0.09	8.9e-07	-5.8	5.5	4.7e-08	-0.70	0.28	0.68	FALSE
44	GTEx	Nerve Tibial	HOXB4	0.09	0.01	lasso	5	0.03	3.2e-03	-5.3	-6.2	7.2e-10	0.63	0.12	0.59	FALSE
45	GTEx	Nerve Tibial	HOXB-AS1	0.14	0.09	lasso	9	0.09	6.7e-07	-6.0	5.8	8.6e-09	-0.71	0.24	0.76	FALSE
46	GTEx	Nerve Tibial	LRRC37A2	0.40	0.51	enet	24	0.55	1.8e-45	-5.9	-5.8	7.8e-09	0.10	0.01	0.99	FALSE
47	GTEx	Ovary	LRRC37A2	0.51	0.44	lasso	8	0.45	1.3e-12	-5.8	-5.7	1.5e-08	0.09	0.01	0.99	FALSE
48	GTEx	Pancreas	LRRC37A2	0.30	0.37	lasso	9	0.38	6.0e-17	-5.9	-5.8	6.3e-09	0.11	0.01	0.99	FALSE
49	GTEx	Pituitary	PNPO	0.15	0.05	lasso	3	0.09	2.3e-03	-5.7	-5.3	1.2e-07	0.41	0.15	0.42	FALSE
50	GTEx	Prostate	LRRC37A2	0.34	0.45	lasso	6	0.43	3.4e-12	-5.8	-5.9	3.7e-09	0.10	0.01	0.99	FALSE
51	GTEx	Skin Not Sun Exposed Suprapubic	HOXB2	0.13	0.08	enet	14	0.11	9.7e-07	-5.8	6.4	1.6e-10	-0.74	0.25	0.72	FALSE
52	GTEx	Skin Not Sun Exposed Suprapubic	LRRC37A2	0.32	0.31	lasso	4	0.35	4.8e-20	-5.8	-6.2	6.4e-10	0.08	0.01	0.99	FALSE
53	GTEx	Skin Not Sun Exposed Suprapubic	LRRC37A17P	0.15	0.07	lasso	7	0.07	1.4e-04	-5.9	5.9	2.7e-09	-0.11	0.01	0.98	FALSE
54	GTEx	Skin Sun Exposed Lower leg	LRRC37A2	0.22	0.33	enet	20	0.35	2.3e-30	-5.9	-6.1	8.0e-10	0.08	0.01	0.99	FALSE
55	GTEx	Small Intestine Terminal Ileum	SNX11	0.29	0.13	lasso	18	0.22	1.2e-05	2.6	-5.1	3.1e-07	0.45	0.34	0.23	FALSE
56	GTEx	Small Intestine Terminal Ileum	LRRC37A2	0.38	0.28	enet	24	0.36	6.8e-09	-5.8	-5.2	1.9e-07	0.12	0.02	0.98	FALSE
57	GTEx	Spleen	HOXB2	0.36	0.19	lasso	9	0.19	1.3e-05	-5.8	5.6	2.1e-08	-0.73	0.14	0.64	FALSE
58	GTEx	Spleen	HOXB-AS1	0.27	0.21	enet	25	0.19	1.5e-05	-6.0	6.2	5.6e-10	-0.71	0.19	0.70	FALSE
59	GTEx	Spleen	LRRC37A2	0.37	0.34	lasso	3	0.40	2.2e-11	-5.7	-5.6	1.8e-08	0.12	0.01	0.99	FALSE
60	GTEx	Stomach	WNT3	0.09	0.08	lasso	10	0.06	6.4e-04	-5.1	-5.2	2.6e-07	0.13	0.11	0.75	FALSE
61	GTEx	Stomach	LRRC37A2	0.32	0.44	lasso	7	0.43	1.3e-22	-5.9	-5.9	2.9e-09	0.10	0.01	0.99	FALSE
62	GTEx	Testis	NSF	0.10	0.10	lasso	4	0.06	7.9e-04	-5.9	-6.0	2.2e-09	0.10	0.01	0.95	FALSE
63	GTEx	Testis	WNT3	0.14	0.10	enet	10	0.14	9.9e-07	-5.1	-5.8	7.3e-09	0.10	0.14	0.85	FALSE
64	GTEx	Testis	LRRC37A17P	0.16	0.21	lasso	6	0.19	1.0e-08	-5.9	5.9	3.3e-09	-0.10	0.01	0.99	FALSE
65	GTEx	Thyroid	HOXB2	0.10	0.07	enet	13	0.06	2.0e-05	-6.0	6.5	6.6e-11	-0.75	0.25	0.75	FALSE
66	GTEx	Thyroid	LRRC37A2	0.25	0.41	lasso	10	0.41	3.7e-33	-5.8	-5.8	5.5e-09	0.11	0.01	0.99	FALSE
67	GTEx	Uterus	HOXB-AS1	0.40	0.06	enet	18	0.13	1.1e-03	1.7	5.1	3.1e-07	-0.52	0.08	0.33	FALSE
68	GTEx	Uterus	LRRC37A2	0.64	0.54	lasso	11	0.56	1.1e-13	-5.9	-6.3	3.7e-10	0.08	0.01	0.99	FALSE
69	GTEx	Vagina	HOXB2	0.16	0.03	lasso	10	0.09	5.3e-03	-5.8	5.8	6.8e-09	-0.74	0.06	0.50	FALSE
70	GTEx	Vagina	LRRC37A2	0.42	0.34	enet	18	0.37	2.6e-09	-5.9	-5.5	4.1e-08	0.09	0.01	0.99	FALSE
71	GTEx	Whole Blood	HOXB3	0.15	0.00	lasso	8	0.00	1.2e-01	-4.1	5.2	1.8e-07	-0.64	0.11	0.36	FALSE
72	GTEx	Whole Blood	HOXB2	0.30	0.16	lasso	8	0.16	3.0e-14	-4.1	5.4	7.7e-08	-0.63	0.99	0.01	FALSE
73	GTEx	Whole Blood	HOXB-AS1	0.14	0.05	enet	27	0.07	6.7e-07	-5.9	5.4	6.2e-08	-0.74	0.36	0.64	FALSE
74	GTEx	Whole Blood	LRRC37A2	0.22	0.27	lasso	9	0.25	3.0e-23	-5.9	-5.9	3.2e-09	0.10	0.01	0.99	FALSE
75	METSIM	Adipose	HOXB2	0.16	0.22	lasso	6	0.22	2.9e-32	-5.8	6.1	8.8e-10	-0.80	0.57	0.43	FALSE
76	NTR	Blood	HOXB2	0.03	0.02	lasso	4	0.02	1.2e-08	-4.0	5.3	1.5e-07	-0.60	0.87	0.13	FALSE
77	YFS	Blood	HOXB2	0.60	0.64	enet	48	0.69	1.0e-320	-4.0	5.2	2.4e-07	-0.60	1.00	0.00	FALSE
78	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	HOXB2	0.03	0.02	enet	3	0.02	3.5e-03	-5.8	5.6	2.4e-08	-0.69	0.05	0.42	FALSE
79	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LRRC37A2	0.28	0.39	lasso	6	0.43	6.6e-40	-5.9	-6.2	7.6e-10	0.08	0.01	0.99	FALSE
80	The Cancer Genome Atlas	Breast Invasive Carcinoma	HOXB4	0.04	0.00	enet	15	0.02	2.6e-04	-5.9	-5.3	9.8e-08	0.52	0.03	0.54	FALSE
81	The Cancer Genome Atlas	Breast Invasive Carcinoma	HOXB6	0.02	0.02	lasso	3	0.01	7.5e-03	-6.1	-6.0	2.0e-09	0.53	0.05	0.52	FALSE
82	The Cancer Genome Atlas	Breast Invasive Carcinoma	LRRC37A2	0.24	0.33	lasso	9	0.33	3.2e-70	-5.9	-6.1	1.1e-09	0.09	0.01	0.99	FALSE
83	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	LRRC37A2	0.44	0.46	blup	48	0.48	1.8e-26	-5.9	-5.9	4.2e-09	0.05	0.01	0.99	FALSE
84	The Cancer Genome Atlas	Colon Adenocarcinoma	LRRC37A2	0.21	0.21	blup	48	0.21	3.0e-12	-5.9	-6.1	1.1e-09	0.09	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Esophageal Carcinoma	LRRC37A2	0.46	0.24	blup	47	0.29	1.1e-09	-5.9	-6.0	2.6e-09	0.04	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Glioblastoma Multiforme	LRRC37A2	0.58	0.33	blup	47	0.34	6.1e-11	-5.9	-6.0	1.5e-09	0.07	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HOXB2	0.03	0.02	blup	47	0.03	5.1e-04	-5.8	5.5	3.6e-08	-0.63	0.14	0.40	FALSE
88	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LRRC37A2	0.19	0.30	lasso	4	0.30	1.4e-33	-5.9	-6.0	1.6e-09	0.09	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HOXB2	0.10	0.04	blup	47	0.04	1.8e-05	-6.3	6.0	2.2e-09	-0.82	0.00	0.99	FALSE
90	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	LRRC37A2	0.33	0.35	lasso	4	0.41	7.2e-50	-5.9	-6.3	3.1e-10	0.07	0.01	0.99	FALSE
91	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WNT3	0.04	0.03	blup	57	0.04	3.2e-05	-5.9	-6.8	9.9e-12	0.06	0.01	0.98	TRUE
92	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	LRRC37A2	0.33	0.34	lasso	7	0.34	6.3e-20	-5.9	-6.2	7.5e-10	0.09	0.01	0.99	FALSE
93	The Cancer Genome Atlas	Brain Lower Grade Glioma	LRRC37A2	0.43	0.51	enet	14	0.54	9.2e-72	-5.9	-6.1	1.2e-09	0.08	0.01	0.99	FALSE
94	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HOXB2	0.19	0.14	lasso	5	0.14	2.5e-07	-6.0	6.0	1.5e-09	-0.75	0.14	0.86	FALSE
95	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	LRRC37A2	0.31	0.33	lasso	6	0.36	9.1e-18	-5.9	-6.2	5.6e-10	0.07	0.01	0.99	FALSE
96	The Cancer Genome Atlas	Lung Adenocarcinoma	HOXB2	0.04	0.02	lasso	4	0.02	4.4e-03	-6.0	6.1	1.3e-09	-0.76	0.13	0.51	FALSE
97	The Cancer Genome Atlas	Lung Adenocarcinoma	LRRC37A2	0.27	0.36	enet	25	0.40	1.5e-50	-5.9	-6.2	6.2e-10	0.08	0.01	0.99	FALSE
98	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	HOXB2	0.02	0.02	enet	7	0.02	6.3e-03	-6.0	6.6	4.1e-11	-0.67	0.04	0.34	FALSE
99	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	LRRC37A2	0.27	0.34	enet	13	0.36	1.5e-42	-5.9	-5.7	9.9e-09	0.06	0.01	0.99	FALSE
100	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	LRRC37A2	0.19	0.25	enet	8	0.28	2.0e-19	-5.9	-6.3	3.0e-10	0.06	0.01	0.99	FALSE
101	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LRRC37A2	0.28	0.36	lasso	6	0.36	3.3e-16	-5.9	-6.0	1.6e-09	0.09	0.01	0.99	FALSE
102	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LRRC37A2	0.29	0.29	lasso	9	0.26	5.4e-11	-5.9	-5.9	3.2e-09	0.10	0.01	0.99	FALSE
103	The Cancer Genome Atlas	Prostate Adenocarcinoma	LRRC37A2	0.35	0.43	enet	18	0.46	5.3e-54	-5.3	-6.1	1.2e-09	0.07	0.02	0.98	FALSE
104	The Cancer Genome Atlas	Prostate Adenocarcinoma	WNT3	0.06	0.11	lasso	2	0.11	7.6e-12	-4.9	-5.3	1.3e-07	0.11	0.12	0.88	FALSE
105	The Cancer Genome Atlas	Rectum Adenocarcinoma	HOXB2	0.15	0.04	blup	46	0.04	3.3e-02	-6.2	6.9	5.8e-12	-0.87	0.01	0.64	TRUE
106	The Cancer Genome Atlas	Rectum Adenocarcinoma	LRRC37A2	0.32	0.24	enet	8	0.33	1.4e-08	-5.9	-6.0	1.8e-09	0.09	0.02	0.98	FALSE
107	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRRC37A2	0.43	0.26	enet	22	0.37	3.8e-23	-5.9	-5.5	3.2e-08	0.00	0.01	0.99	FALSE
108	The Cancer Genome Atlas	Skin Cutaneous Melanoma	LRRC37A2	0.37	0.27	enet	15	0.34	5.2e-10	-5.9	-6.3	3.6e-10	0.05	0.01	0.99	FALSE
109	The Cancer Genome Atlas	Stomach Adenocarcinoma	LRRC37A2	0.27	0.27	lasso	6	0.30	2.8e-22	-5.9	-6.2	4.3e-10	0.07	0.01	0.99	FALSE
110	The Cancer Genome Atlas	Testicular Germ Cell Tumors	LRRC37A2	0.40	0.14	lasso	6	0.21	4.4e-08	3.8	-5.5	4.5e-08	0.03	0.15	0.82	FALSE
111	The Cancer Genome Atlas	Thyroid Carcinoma	HOXB2	0.05	0.07	blup	47	0.07	2.0e-07	-6.0	6.2	6.2e-10	-0.72	0.24	0.76	FALSE
112	The Cancer Genome Atlas	Thyroid Carcinoma	HOXB6	0.04	0.00	blup	51	0.01	3.3e-02	-4.7	5.5	4.9e-08	-0.66	0.06	0.16	FALSE
113	The Cancer Genome Atlas	Thyroid Carcinoma	LRRC37A2	0.44	0.46	lasso	10	0.50	4.3e-56	-5.9	-6.2	5.7e-10	0.09	0.01	0.99	FALSE
114	The Cancer Genome Atlas	Thyroid Carcinoma	WNT3	0.05	0.05	lasso	3	0.06	2.7e-06	-4.7	-5.1	3.1e-07	0.11	0.24	0.74	FALSE
115	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	LRRC37A2	0.34	0.21	blup	48	0.29	9.1e-09	-5.9	-5.8	6.6e-09	0.08	0.02	0.98	FALSE