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chr17:60,821,100-62,694,738

Best TWAS P=2.27e-13 · Best GWAS P=4.71e-12 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
3	GTEx	Adipose Subcutaneous	CD79B	0.15	0.16	enet	9	0.17	3.5e-14	-6.6	7.3	2.3e-13	-0.98	0.01	0.99	TRUE
7	GTEx	Brain Hippocampus	CYB561	0.33	0.24	enet	29	0.27	4.3e-07	-3.8	6.0	2.1e-09	-0.07	0.58	0.04	TRUE
10	GTEx	Breast Mammary Tissue (Female)	CD79B	0.04	0.07	lasso	2	0.03	4.2e-02	-6.8	6.9	3.7e-12	-0.70	0.02	0.55	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	CD79B	0.02	0.02	lasso	2	0.01	3.0e-03	-6.9	6.8	1.3e-11	-0.99	0.00	0.91	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	PSMC5	0.04	0.03	lasso	1	0.03	5.6e-04	-6.8	-6.8	1.4e-11	0.76	0.00	0.97	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	STRADA	0.05	0.03	lasso	1	0.02	1.7e-03	-6.7	-6.7	2.1e-11	0.75	0.00	0.91	FALSE
14	GTEx	Esophagus Mucosa	STRADA	0.05	0.07	lasso	2	0.05	1.9e-04	-6.7	-6.6	3.2e-11	0.74	0.02	0.92	FALSE
15	GTEx	Esophagus Muscularis	PSMC5	0.12	0.08	lasso	3	0.07	3.8e-05	-6.7	-6.3	2.4e-10	0.74	0.02	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KCNH6	0.04	0.02	enet	9	0.04	1.4e-05	6.1	6.3	3.7e-10	-0.49	0.35	0.55	FALSE
4	GTEx	Adipose Subcutaneous	MAP3K3	0.09	0.07	lasso	6	0.07	3.5e-06	6.1	6.2	6.6e-10	-0.34	0.43	0.57	FALSE
13	GTEx	Cells Transformed fibroblasts	PSMC5	0.19	0.09	lasso	5	0.10	7.1e-08	-6.7	-6.2	7.3e-10	0.68	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	MAP3K3	0.07	0.10	lasso	2	0.08	4.1e-06	6.2	6.2	7.5e-10	-0.35	0.40	0.59	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	STRADA	0.03	0.00	blup	57	0.01	5.2e-02	-6.7	6.1	8.1e-10	-0.73	0.00	0.82	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	DDX42	0.11	0.14	lasso	2	0.12	1.3e-04	6.1	-6.1	8.7e-10	0.36	0.22	0.34	FALSE
16	GTEx	Esophagus Muscularis	DCAF7	0.08	0.06	lasso	7	0.05	6.7e-04	6.1	6.1	1.0e-09	-0.35	0.36	0.49	FALSE
11	GTEx	Breast Mammary Tissue (Female)	MAP3K3	0.07	0.01	lasso	1	0.00	4.1e-01	6.1	6.1	1.1e-09	-0.36	0.04	0.22	FALSE
25	GTEx	Testis	PSMC5	0.14	0.13	lasso	6	0.14	6.0e-07	5.8	-6.1	1.2e-09	0.37	0.42	0.56	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K3	0.12	0.13	enet	10	0.15	1.8e-08	6.1	6.0	1.7e-09	-0.36	0.40	0.60	FALSE
23	GTEx	Skin Sun Exposed Lower leg	MAP3K3	0.08	0.08	lasso	3	0.08	6.8e-07	6.1	6.0	1.9e-09	-0.34	0.40	0.59	FALSE
6	GTEx	Artery Tibial	MAP3K3	0.05	0.07	lasso	5	0.07	2.9e-06	5.6	6.0	2.1e-09	-0.39	0.50	0.40	FALSE
9	GTEx	Breast Mammary Tissue	MAP3K3	0.10	0.11	lasso	8	0.08	8.9e-05	6.1	6.0	2.2e-09	-0.36	0.41	0.57	FALSE
24	GTEx	Spleen	MAP3K3	0.21	0.14	lasso	10	0.10	1.4e-03	6.2	5.9	2.8e-09	-0.34	0.30	0.39	FALSE
27	NTR	Blood	MAP3K3	0.02	0.01	lasso	2	0.01	2.0e-04	5.6	-5.9	2.9e-09	0.39	0.83	0.16	FALSE
20	GTEx	Pancreas	MAP3K3	0.10	0.08	lasso	4	0.07	9.0e-04	6.1	5.9	3.6e-09	-0.27	0.11	0.30	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SMARCD2	0.03	0.03	blup	330	0.03	1.1e-04	5.8	5.8	7.6e-09	-0.24	0.42	0.48	FALSE
5	GTEx	Adipose Visceral Omentum	CD79B	0.15	0.00	lasso	6	0.02	4.1e-02	-6.6	5.8	8.6e-09	-0.89	0.04	0.75	FALSE
18	GTEx	Muscle Skeletal	SMARCD2	0.13	0.03	lasso	5	0.04	1.3e-04	-6.7	-5.7	9.8e-09	0.59	0.02	0.98	FALSE
17	GTEx	Lung	MAP3K3	0.07	0.07	lasso	2	0.06	2.8e-05	5.7	5.6	1.6e-08	-0.36	0.43	0.55	FALSE
36	The Cancer Genome Atlas	Thyroid Carcinoma	MAP3K3	0.02	0.02	blup	52	0.01	1.4e-02	5.7	5.6	2.7e-08	-0.27	0.05	0.36	FALSE
26	NTR	Blood	LIMD2	0.04	0.03	blup	304	0.03	2.2e-10	5.6	-5.5	5.0e-08	0.42	0.52	0.48	FALSE
32	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	STRADA	0.07	0.01	blup	57	0.03	5.5e-04	1.3	5.4	5.4e-08	-0.70	0.01	0.87	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	DDX42	0.23	0.04	lasso	12	0.07	8.1e-03	6.2	-5.2	1.6e-07	0.33	0.16	0.22	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	SCN4A	0.04	0.01	blup	39	0.03	1.4e-07	-6.9	-5.2	1.7e-07	0.74	0.01	0.99	FALSE
21	GTEx	Pituitary	MAP3K3	0.11	0.07	lasso	6	0.04	3.5e-02	6.1	5.2	2.0e-07	-0.28	0.12	0.11	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	SMARCD2	0.08	0.04	blup	28	0.04	5.1e-05	5.8	5.2	2.1e-07	-0.26	0.29	0.55	FALSE
28	YFS	Blood	LIMD2	0.03	0.03	enet	11	0.03	3.6e-11	5.2	-5.2	2.2e-07	0.42	0.89	0.11	FALSE