TWAS hub - HOXB6

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0225	0.0125	0.0034	0.015	0.007	0.006	NA	0.008	0.00032	0.0110	0.020	NA	0.0075
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0445	0.0217	0.0025	0.014	0.034	0.006	NA	0.009	0.00930	0.0001	0.067	NA	0.0320
3	TCGA	Thyroid Carcinoma	0.0360	0.0210	0.0044	0.003	0.010	0.000	NA	0.006	0.14000	0.0330	0.340	NA	0.0790

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Ovarian Cancer	11.3	15.0	25.2	-5.0	-3.5	2.7
Hand grip strength (left)	10.1	26.5	38.1	-6.2	-2.0	6.1
Hand grip strength (right)	8.9	24.2	36.0	-6.0	-2.6	5.5
Health satisfaction	6.6	8.6	12.0	-3.5	-2.8	2.5
Blood Red Count	5.2	49.9	66.6	-8.2	-7.0	5.9
Financial situation satisfaction	5.1	6.3	8.2	-2.8	-2.9	1.7
Tinnitus: Yes, now most or all of the time	5.1	5.9	8.6	-2.9	-2.4	1.9
Illnesses of siblings: Diabetes	5.0	6.1	10.6	3.3	2.5	-1.2
Hearing difficulty/problems: Yes	4.9	7.5	9.0	-3.0	-2.2	3.0
Exposure to tobacco smoke outside home	4.6	6.1	11.6	-2.0	-1.6	3.4
Ever had bowel cancer screening	4.5	5.3	6.8	2.4	1.8	-2.6
Overall health rating	4.4	9.4	11.1	-3.3	-3.0	2.8
Lung FVC	4.2	21.2	38.7	-6.2	-3.7	3.4
Worry too long after embarrassment	4.1	6.8	12.7	-2.6	-3.6	0.9
Pulse wave Arterial Stiffness index	4.0	4.7	7.5	2.5	0.6	-2.7
Peak expiratory flow (PEF)	4.0	9.2	14.9	3.2	1.6	-3.9
Systolic blood pressure, automated reading	3.9	11.5	23.4	3.3	4.8	-0.0
Mouth/teeth dental problems: Dentures	3.9	6.6	10.0	-2.9	-3.2	1.1
Type 2 Diabetes (T2D) (2012)	3.8	4.4	5.2	2.3	2.1	-1.9
Pulse wave peak to peak time	3.8	4.5	7.0	-2.6	-1.0	2.4
Blood clot in the leg (DVT)	3.6	4.7	9.9	-2.0	-3.1	-0.4
Mouth/teeth dental problems: Loose teeth	3.6	4.3	6.4	2.5	1.4	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.6	7.6	13.4	-3.7	-2.8	1.2
Migraine (self-reported)	3.5	4.4	8.7	-2.0	-3.0	-0.8
Deep venous thrombosis (DVT) (self-reported)	3.4	4.4	9.5	-1.7	-3.1	-0.9
Medication: Ventolin 100micrograms inhaler	3.3	4.2	8.4	-1.8	-1.1	2.9
Rheumatoid Arthritis	3.2	4.3	8.5	2.1	0.4	-2.9
Systolic Blood Pressure	3.2	16.0	26.5	4.2	5.2	-1.9
Wheeze or whistling in the chest in last year	3.2	5.8	12.8	-2.0	-0.6	3.6
Family relationship satisfaction	3.2	4.0	6.1	-2.4	-2.5	0.5
Glaucoma (self-reported)	3.1	3.7	5.8	-2.3	-2.4	0.4
Average weekly spirits intake	2.8	3.5	4.3	-2.1	-1.6	1.9
Basal cell carcinoma (self-reported)	2.8	3.4	4.5	-2.1	-1.6	1.8
Allergy	2.7	6.1	7.6	2.8	2.0	-2.6
Frequency of tiredness / lethargy in last 2 weeks	2.7	4.4	6.7	-2.2	-2.6	1.2
Comparative body size at age 10	2.7	7.5	17.3	-0.6	2.2	4.2
Pain type(s) experienced in last month: Hip pain	2.6	3.3	5.4	-2.0	-2.3	0.6
Waist circumference	2.5	9.3	23.5	-2.1	-0.3	4.8
LDL Cholesterol	2.4	3.9	5.9	-2.1	-1.1	2.4
Sitting height	2.4	16.9	43.0	2.6	-1.0	-6.6
Forced expiratory volume in 1-second (FEV1), Best measure	2.4	7.6	11.8	-3.4	-3.2	-0.8
Angina	2.3	3.0	3.7	1.7	1.6	-1.9
Forced vital capacity (FVC), Best measure	2.3	8.2	12.7	-3.6	-3.4	-0.9
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	4.1	1.9	2.0	-0.6
Respiratory disease	2.2	5.0	9.9	-2.3	0.0	3.1
Bilateral oophorectomy (both ovaries removed)	2.2	2.6	5.4	1.5	-0.4	-2.3
Medication: Levothyroxine sodium	2.2	3.7	5.9	-2.4	-2.3	0.1
Number of children fathered	2.2	2.5	4.2	-2.1	-1.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.2	2.6	4.6	-1.8	0.2	2.1
Chest pain or discomfort	2.2	3.2	4.6	-2.1	-2.0	0.9
Fasting Glucose	2.1	2.5	5.4	1.1	2.3	-1.0
Angina (self-reported)	2.1	2.7	4.0	1.5	1.3	-2.0
Guilty feelings	2.1	3.2	4.3	-2.1	-1.5	1.8
Age at First Birth	2.0	2.9	4.7	2.2	1.9	-0.5
Medication: Gliclazide	2.0	2.2	5.7	1.0	-0.1	-2.4
Eye problems/disorders: Glaucoma	2.0	2.4	3.9	-1.8	-2.0	0.5
Impedance of whole body	2.0	10.0	20.0	3.1	0.6	-4.5
Body Mass Index (BMI) (2010)	1.9	2.6	4.8	-1.7	-0.5	2.2
Chronic bronchitis/emphysema (father)	1.9	2.2	4.1	2.0	0.5	-1.5
Body mass index (BMI)	1.9	8.0	19.7	-2.0	-0.4	4.4
Impedance of arm (right)	1.9	8.9	16.6	3.1	0.8	-4.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	4.4	-1.5	-2.1	-0.4
Depressed Affect (Nagel 2018)	1.8	3.7	6.2	-0.6	-2.5	-2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	6.8	-1.6	-2.6	-1.2
Back pain experienced in last month	1.8	2.6	5.4	-0.7	-2.3	-1.4
Asthma (self-reported)	1.8	3.6	8.0	-1.6	0.4	2.8
Illnesses of father: None of the above (group 1)	1.8	2.2	3.5	0.4	1.9	1.8
Cholesterol lowering medication	1.8	2.6	4.7	-0.1	2.2	1.8
Pain experienced in last month	1.8	3.0	6.9	1.4	2.6	0.5
Schizophrenia vs Biploar Disorder	1.7	2.2	4.5	-1.3	-2.1	0.8
Townsend deprivation index at recruitment	1.7	2.4	6.2	-0.7	0.7	2.5
Fed-up feelings	1.7	3.0	7.1	-1.1	-2.7	-0.8
Impedance of leg (left)	1.7	8.1	12.3	3.1	1.5	-3.5
Financial difficulties in last 2 years	1.7	2.3	4.4	-1.5	-2.1	0.4
Happiness	1.7	2.0	2.7	-1.6	-1.6	0.9
Asthma	1.7	3.3	7.1	-1.7	0.3	2.7
Headache pain in last month	1.7	3.0	7.2	-1.3	-2.7	0.0
Height	1.6	31.5	78.5	3.4	-2.1	-8.9
Frequency of depressed mood in last 2 weeks	1.6	2.3	4.2	-1.5	-2.0	0.5
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.1	1.8	1.3	-1.2
Medication for hormone replacement therapy	1.6	1.8	2.7	1.6	0.3	-1.6
Medication: Metformin	1.6	2.2	4.0	2.0	0.9	-1.4
Hypothyroidism/myxoedema (self-reported)	1.6	3.2	4.8	-2.2	-2.2	-0.1
BMI	1.5	8.9	20.2	-2.3	-1.0	4.5
Forced vital capacity (FVC)	1.5	5.9	8.9	-2.8	-3.0	-1.0
Forced expiratory volume in 1-second (FEV1)	1.5	5.2	7.7	-2.8	-2.7	-0.9
Standing height	1.5	14.4	36.5	1.3	-2.2	-6.0
Commuting to job workplace: Walk	1.5	1.6	2.5	-1.5	-0.1	1.6
Diabetes (father)	1.4	1.8	4.4	-0.6	-2.1	-0.8
Serious illness, injury or assault to yourself	1.4	1.7	3.5	-1.2	-1.9	0.2
Hayfever, allergic rhinitis or eczema	1.4	3.1	3.5	-1.8	-1.6	1.9
Impedance of arm (left)	1.4	6.4	13.9	2.3	-0.0	-3.7
Tense / ‘highly strung’	1.4	2.4	3.4	-1.8	-1.8	0.8
High cholesterol (Self-reported)	1.4	2.5	4.2	-1.8	0.2	2.1
Risk taking	1.4	2.1	4.3	0.3	-1.4	-2.1
Lung FEV1/FVC ratio	1.3	6.6	13.3	2.2	1.2	-3.6
Age when periods started (menarche)	1.3	3.0	5.8	1.8	0.2	-2.4
Illnesses of siblings	1.3	1.8	2.8	-1.7	-1.5	0.6
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.4	2.5	1.2	0.6	-1.6
Medication: Lansoprazole	1.3	1.4	1.7	1.3	1.0	-1.3
Alcohol drinker status: Never	1.3	1.6	1.9	-1.4	-1.4	1.0
Depression (Nagel 2018)	1.2	1.8	3.9	-1.0	-2.0	-0.7
Alzheimer’s Disease (in father)	1.2	1.3	2.6	0.2	-1.1	-1.6
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.8	1.7	1.1	-2.2
Prostate Cancer	1.2	1.7	2.6	1.6	0.4	-1.6
Impedance of leg (right)	1.2	5.9	8.6	2.6	1.6	-2.9
Had other major operations	1.2	1.4	2.8	-1.2	-0.3	1.7
Mouth/teeth dental problems	1.2	1.8	2.6	1.6	1.6	-0.7
Neuroticism (Nagel 2018)	1.1	2.5	5.2	-1.4	-2.3	-0.7
Crohns Disease (2012)	1.1	1.7	2.8	-1.7	-1.2	1.0
Waist Hip Ratio (WHR)	1.1	5.0	10.9	-2.0	-0.2	3.3
Hypothyroidism (self reported)	1.1	2.6	4.1	-1.9	-2.0	-0.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	2.9	0.9	0.4	-1.7
Medication: Amlodipine	1.1	1.5	2.1	1.4	1.4	-0.8
Leg fat percentage (right)	1.1	3.9	10.7	-0.6	0.8	3.3
Emphysema/chronic bronchitis	1.1	1.2	2.1	-1.2	-1.5	0.3
Medication: Blood pressure	1.1	1.9	2.4	1.6	1.5	-1.1
Average weekly champagne plus white wine intake	1.1	1.5	2.7	1.3	0.4	-1.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.2	-0.0	1.4	1.5
Medication: Lisinopril	1.1	1.4	2.0	1.0	1.4	-1.1
Coronary Artery Disease (CAD)	1.0	1.2	2.3	-1.1	-1.5	-0.2
Blood Platelet Count	1.0	12.1	18.9	4.3	2.5	-3.3
Maternal smoking around birth	1.0	1.5	2.5	1.2	-0.8	-1.6
High blood pressure	1.0	2.7	5.1	1.6	2.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.6	-1.4	-1.6	0.2
Hearing difficulty/problems with background noise	1.0	1.6	2.6	-1.2	-1.6	0.9
Fluid intelligence score	1.0	2.1	4.9	1.2	-0.3	-2.2
Pulse wave reflection index	1.0	1.2	2.8	0.8	-0.5	-1.7
Age at last live birth	1.0	1.4	2.4	1.4	1.6	0.3
Hearing aid user	1.0	1.2	1.8	-1.1	-1.3	0.6
Illnesses of father: High blood pressure	1.0	1.3	1.9	-1.4	-1.4	-0.2
Ever had prostate specific antigen (PSA) test	1.0	1.2	2.6	0.9	-0.3	-1.6
Ulcerative Colitis (UC)	0.9	1.7	3.8	-1.0	-1.9	-0.7
Lupus	0.9	1.3	2.6	1.0	1.6	0.7
Neuroticism	0.9	2.3	4.9	-1.1	-2.2	-0.8
Stomach or abdominal pain in last month	0.9	1.2	2.0	-0.7	-1.4	-1.0
Supplements: Glucosamine	0.9	1.1	2.2	1.5	1.1	-0.1
Neuroticism score	0.9	1.9	4.0	-1.3	-2.0	0.1
Depression (self-reported)	0.9	1.1	3.1	0.1	-0.4	-1.8
Number of full brothers	0.9	1.1	2.4	-0.9	-1.6	0.4
Shortness of breath walking on level ground	0.9	1.0	1.8	-1.1	-1.3	0.4
Medication: Ibuprofen	0.9	1.1	2.3	-1.0	-1.5	-0.1
Medication: Allopurinol	0.9	1.2	2.2	1.1	1.5	0.4
Arm fat percentage (left)	0.9	3.6	9.5	-1.1	-0.5	3.1
Long-standing illness, disability or infirmity	0.9	1.4	1.8	-1.2	-1.0	1.4
Diabetes diagnosed by doctor	0.9	1.5	2.9	1.7	0.1	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.9	0.9	1.6	-0.1	-1.2	-1.1
Wears glasses or contact lenses	0.9	1.0	2.5	-0.1	1.6	0.8
Medication: Bendroflumethiazide	0.9	1.4	3.4	0.9	-0.1	-1.8
Average weekly beer plus cider intake	0.9	1.3	2.8	1.7	0.7	-0.8
Alcohol drinker status: Previous	0.9	1.0	1.7	0.4	-1.1	-1.3
Intelligence (Savage-Jansen 2018)	0.8	2.6	3.2	1.4	1.8	-1.6
Alzheimer’s Disease (including proxy)	0.8	1.1	2.7	-0.5	-1.6	-0.7
HbA1C	0.8	0.9	1.6	1.3	0.7	-0.8
Blood White Count	0.8	5.7	8.9	3.0	0.7	-2.8
Allergy or Eczema	0.8	2.2	3.0	-1.4	-1.7	1.2
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	2.4	-0.7	-1.6	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.0	-1.0	-1.4	0.0
Number of incorrect matches in round	0.8	1.4	2.5	1.2	0.6	-1.6
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.7	0.6	0.0	-1.6
Pain all over the body in last month	0.8	0.9	2.0	-0.8	-1.4	-0.3
Medication: Simvastatin	0.8	1.2	1.8	-0.5	1.2	1.4
Arm fat percentage (right)	0.8	3.1	8.9	-0.7	-0.1	3.0
Hip circumference	0.8	3.7	7.0	-1.7	-1.1	2.6
Qualifications: College or University degree	0.8	2.6	3.0	1.7	1.4	-1.6
Leg fat mass (right)	0.8	3.0	8.2	-0.8	0.1	2.9
Qualifications: nursing, teaching	0.8	1.3	2.0	1.4	0.2	-1.4
Arm fat mass (left)	0.8	3.4	7.3	-1.4	-1.0	2.7
Leg fat percentage (left)	0.8	2.8	7.9	-0.3	0.7	2.8
Crohns Disease (2017)	0.7	1.5	2.3	-1.4	-1.5	0.5
Triglycerides	0.7	1.2	2.1	0.1	-1.2	-1.4
Ever had hysterectomy (womb removed)	0.7	0.8	1.9	0.2	-0.6	-1.4
Diabetes (self-reported)	0.7	1.1	1.7	1.3	-0.3	-1.3
Worrier / anxious feelings	0.7	1.4	1.8	-1.4	-0.9	1.3
Prospective memory result	0.7	0.9	2.0	0.6	1.4	0.5
Illnesses of mother	0.7	0.9	1.5	0.4	1.2	1.0
Arm fat mass (right)	0.7	3.1	7.2	-1.2	-0.7	2.7
Exposure to tobacco smoke at home	0.7	0.8	1.6	0.2	-1.3	-0.9
Birth weight of first child	0.7	1.4	2.4	0.3	1.3	1.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.4	0.2	-1.2	-0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	1.3	-1.1	-1.1	0.2
Age at first live birth	0.7	1.3	2.2	1.3	1.5	0.1
Eye problems/disorders: None of the above	0.7	0.8	1.4	0.9	0.3	-1.2
Medication for pain relief, constipation, heartburn	0.7	1.1	2.2	0.8	1.5	0.8
Pulse rate, automated reading	0.7	2.3	5.2	-0.2	1.3	2.3
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.5	-1.2	-0.4	1.0
Number of self-reported non-cancer illnesses	0.7	1.3	1.8	-1.3	-0.5	1.4
Fractured/broken bones in last 5 years	0.7	1.0	1.8	1.3	0.4	-1.0
Bipolar Disorder (2018)	0.6	1.0	1.7	0.5	1.3	1.0
Worry (Nagel 2018)	0.6	1.3	2.1	-1.5	-1.3	0.5
Alzheimer’s Disease (in mother)	0.6	0.7	1.7	-0.7	-1.3	-0.3
Irritable Bowel Disease (IBD)	0.6	1.5	3.2	-1.1	-1.8	-0.3
Primary Biliary Cirrhosis	0.6	0.8	1.3	-1.2	-0.9	0.7
Chronotype (morning person)	0.6	1.4	2.1	-1.1	0.9	1.5
Sensitivity / hurt feelings	0.6	1.1	2.3	-0.2	-1.5	-0.9
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.8	-0.4	-1.4	-0.3
Severe depression (siblings)	0.6	0.6	1.0	0.9	0.2	-1.0
Multivitamins +/- minerals	0.6	0.8	0.9	1.0	0.8	-0.9
Medication: Atenolol	0.6	0.8	1.9	0.6	1.4	-0.2
Alcohol usually taken with meals	0.6	0.9	2.2	0.5	0.6	-1.5
Had menopause	0.6	0.8	1.0	0.9	1.0	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.8	-0.8	-0.4	1.3
Falls in the last year	0.6	0.8	1.2	0.2	-1.1	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	-0.6	-1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.6	0.9	1.7	-0.9	-1.3	0.5
Medication: Omeprazole	0.6	0.7	1.1	0.3	1.0	0.9
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-0.8	-1.3	-0.1
Arm predicted mass (right)	0.6	3.3	4.4	-2.1	-2.1	1.0
Commuting to job workplace: Car/motor vehicle	0.6	0.7	1.2	-0.0	-1.0	-1.1
Hypertension (Self-reported)	0.6	1.7	2.8	1.3	1.7	-0.7
Eye problems/disorders: Cataract	0.6	0.7	1.7	-0.2	0.7	1.3
Medication for cholesterol	0.6	0.8	1.6	-0.9	-1.3	0.3
Mineral and other dietary supplements	0.6	0.8	1.8	-0.5	-1.4	-0.6
Ever taken oral contraceptive pill	0.6	0.6	1.4	0.7	0.2	-1.2
Irritability	0.6	1.1	1.6	-1.2	-1.3	0.5
Vascular/heart problems diagnosed by doctor	0.6	1.6	2.9	-1.2	-1.7	0.8
Leg fat mass (left)	0.6	2.4	6.6	-0.7	0.0	2.6
Major Depression (MDD)	0.5	0.7	1.3	0.3	-0.8	-1.1
Medication: Co-codamol	0.5	0.5	1.2	0.6	0.1	-1.1
Leg fat-free mass (left)	0.5	2.8	4.1	-1.8	-2.0	1.0
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.8	-0.8	-0.4	0.9
Leg predicted mass (left)	0.5	2.9	4.4	-1.8	-2.1	1.0
Alcohol intake versus 10 years previously	0.5	0.7	1.3	0.8	1.1	0.3
Hair/balding pattern: Pattern 3	0.5	0.7	1.6	-0.1	0.6	1.3
Number of live births	0.5	0.7	1.2	-1.1	-0.8	0.5
Ever highly irritable/argumentative for 2 days	0.5	0.6	1.4	0.3	-0.5	-1.2
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.1	-0.8	-1.0	0.3
High blood pressure (siblings)	0.5	0.8	1.4	0.8	0.5	-1.2
Heart disease (mother)	0.5	0.6	1.0	-0.8	-1.0	-0.0
Comparative height size at age 10	0.5	3.0	7.8	0.1	-1.1	-2.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.7	-0.1	0.5	1.3
Leg fat-free mass (right)	0.5	2.7	4.8	-1.7	-2.2	0.7
Average weekly red wine intake	0.5	0.7	1.3	-0.9	0.0	1.1
Medication: Aspirin	0.5	0.6	1.8	0.3	0.0	-1.3
Leg predicted mass (right)	0.5	2.9	5.1	-1.8	-2.2	0.7
Medication: Atorvastatin	0.5	0.7	1.1	-0.8	0.5	1.1
Number of operations (self-reported)	0.5	0.8	1.4	1.2	0.2	-1.0
Diastolic blood pressure, automated reading	0.5	1.6	3.5	-1.2	-0.0	1.9
Reaction Time	0.4	0.7	0.9	-1.0	-0.8	0.7
Mean Putamen Volume	0.4	0.5	1.0	1.0	0.7	-0.1
Neuroticism (2016)	0.4	0.6	1.2	0.1	-0.7	-1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.3	1.1	-0.4	-1.1
Supplements: Zinc	0.4	0.4	1.0	-0.4	-0.4	1.0
Pack years adult smoking proportion	0.4	0.7	1.0	0.4	0.9	1.0
Qualifications: CSEs or equivalent	0.4	0.5	1.4	-0.5	-1.2	-0.2
Weight	0.4	1.7	2.3	-1.2	-1.2	1.5
Father’s age at death	0.4	0.5	1.5	0.3	-0.1	-1.2
Pulse rate	0.4	0.7	1.0	-0.8	-1.0	0.6
Qualifications: A levels/AS levels or equivalent	0.4	0.9	1.4	1.2	0.9	-0.8
Medication: Cholesterol lowering	0.4	0.6	0.9	-0.4	0.9	0.9
Lung cancer (father)	0.4	0.5	1.0	-0.1	-0.7	-1.0
Length of working week for main job	0.4	0.4	0.8	-0.6	-0.9	0.4
Arm fat-free mass (right)	0.4	2.3	3.1	-1.8	-1.7	0.9
Suffer from ‘nerves’	0.4	0.6	1.7	0.3	-0.4	-1.3
Medication: Aspirin	0.4	0.6	1.4	0.4	0.4	-1.2
Whole body fat-free mass	0.4	2.0	3.1	-1.6	-1.8	0.6
Whole body water mass	0.4	2.4	3.6	-1.8	-1.9	0.7
Miserableness	0.4	0.7	1.6	-0.3	-1.3	-0.6
Medication: Blood pressure	0.4	0.8	1.6	0.8	1.2	-0.3
Medication: Paracetamol	0.4	0.6	1.8	-0.4	-1.3	0.0
Basal metabolic rate	0.4	2.3	3.1	-1.6	-1.8	1.0
Arm fat-free mass (left)	0.4	2.0	2.6	-1.6	-1.6	0.9
Commuting to job workplace: Cycle	0.4	0.5	1.1	0.6	-0.1	-1.1
Supplements: Calcium	0.4	0.4	1.0	0.4	1.0	0.2
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	0.2	0.5	1.4
Cardiovascular Disease	0.3	0.9	2.4	0.2	1.5	0.6
Relative age of first facial hair	0.3	0.6	1.5	0.3	-0.4	-1.2
Time employed in main current job	0.3	0.4	0.6	-0.8	-0.7	-0.3
Breastfed as a baby	0.3	0.3	0.5	0.7	0.4	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	0.9	0.1	-0.6	-1.0
Medication: Paracetamol	0.3	0.6	0.9	0.8	-0.3	-1.0
Gout (self-reported)	0.3	0.5	1.0	0.6	1.0	0.2
Body fat percentage	0.3	1.2	3.6	0.0	0.1	1.9
Had major operations	0.3	0.4	0.7	0.5	-0.4	-0.9
Supplements: Vitamin C	0.3	0.3	0.8	-0.1	0.2	0.9
Friendships satisfaction	0.3	0.4	0.7	-0.8	-0.8	-0.0
Osteoporosis (self-reported)	0.3	0.4	0.9	0.5	-0.0	-0.9
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.2	0.7	0.9
Commuting to job workplace: Public transport	0.3	0.4	0.9	-0.5	-0.1	1.0
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	-0.1	0.5	0.8
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.3	-0.4	-0.9
Pack years of smoking	0.3	0.4	0.8	0.6	0.9	0.4
Arm predicted mass (left)	0.3	1.4	2.0	-1.3	-1.4	0.7
Schizophrenia (2018)	0.2	0.5	1.2	-0.1	-0.4	1.1
Schizophrenia (2014)	0.2	0.4	0.8	-0.0	-0.7	0.9
Blood Eosinophil Count	0.2	1.4	2.8	1.1	1.7	0.6
Smoking Status	0.2	0.4	0.8	-0.4	-0.9	-0.6
Tanning	0.2	2.7	6.9	-0.9	0.6	2.6
Number of treatments/medications taken	0.2	0.3	0.4	0.7	0.5	-0.3
Average weekly fortified wine intake	0.2	0.3	0.7	0.2	0.8	-0.3
Relative age voice broke	0.2	0.3	0.5	0.3	-0.7	-0.7
High blood pressure (mother)	0.2	0.3	0.5	-0.4	-0.7	-0.6
Heart attack	0.2	0.3	0.6	-0.4	-0.4	-0.8
Trunk fat-free mass	0.2	1.3	2.0	-1.3	-1.4	0.2
Noisy workplace	0.2	0.2	0.4	-0.5	-0.1	0.7
Trunk predicted mass	0.2	1.3	2.1	-1.3	-1.4	0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.5	1.0	0.1
Whole body fat mass	0.2	1.0	2.7	-0.3	-0.4	1.6
Alcohol intake frequency.	0.2	0.5	1.4	-0.2	0.2	1.2
Number of full sisters	0.2	0.3	0.6	-0.3	0.3	0.8
Leg pain on walking	0.2	0.3	0.5	-0.4	-0.3	0.7
Mood swings	0.2	0.4	0.9	-0.3	-1.0	-0.5
Loneliness, isolation	0.2	0.2	0.5	-0.2	-0.7	-0.4
Unable to work because of sickness or disability	0.2	0.2	0.4	0.5	0.7	0.1
Breast Cancer	0.1	0.3	0.5	0.7	0.4	-0.5
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.5	0.0	0.0
Ulcerative Colitis	0.1	0.1	0.2	-0.1	-0.5	-0.1
Heel T-Score	0.1	0.4	0.7	0.1	0.8	0.8
Hair Pigment	0.1	3.0	6.4	0.2	-1.6	-2.5
Diabetes (mother)	0.1	0.1	0.2	0.2	-0.5	-0.3
Trunk fat percentage	0.1	0.4	1.2	0.3	-0.2	1.1
Current tobacco smoking	0.1	0.2	0.6	-0.1	-0.8	-0.4
Trunk fat mass	0.1	0.4	1.0	0.1	-0.4	1.0
Nervous feelings	0.1	0.2	0.5	0.1	0.5	0.7
Hair/balding pattern: Pattern 2	0.1	0.2	0.4	-0.7	-0.3	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.5	-0.7	-0.7	-0.0
Qualifications: None of the above	0.1	0.1	0.2	0.2	0.5	-0.4
Loud music exposure frequency	0.1	0.1	0.3	-0.0	0.6	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.3	-0.5	-0.2	0.3
Birth weight	0.1	0.2	0.4	-0.2	0.5	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.1	-0.3	0.1	0.3
Neck or shoulder pain in last month	0.1	0.2	0.3	0.5	-0.3	-0.4
Mean time to correctly identify matches	0.1	0.2	0.5	-0.7	0.1	0.4
Knee pain experienced in last month	0.1	0.2	0.4	0.0	-0.5	0.6
Smoking status: Previous	0.1	0.1	0.3	-0.2	0.3	0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.4	0.4	0.6	0.1
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.2	-0.5	0.1
Breast cancer (self-reported)	0.1	0.1	0.1	0.4	0.4	-0.4
Smoking status: Current	0.1	0.1	0.2	0.1	-0.5	-0.4
Mother’s age at death	0.1	0.1	0.2	0.0	0.0	-0.4
Ever smoked	0.1	0.2	0.4	0.5	0.7	-0.1
Age started oral contraceptive pill	0.1	0.1	0.1	-0.4	0.1	0.3
Myopia	0.1	0.2	0.5	0.1	0.7	-0.0
Heart disease (siblings)	0.1	0.1	0.2	-0.1	0.4	-0.3
HDL Cholesterol	0.0	0.1	0.2	0.4	0.3	0.1
Vitamin and mineral supplements	0.0	0.1	0.1	0.3	0.0	0.2
Taking other prescription medications	0.0	0.0	0.1	0.2	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.1	0.2	-0.4	0.0	-0.1
Past tobacco smoking	0.0	0.1	0.1	-0.1	-0.4	-0.2
Medication: Ramipril	0.0	0.1	0.1	0.2	0.0	-0.4
Illnesses of father: Heart disease	0.0	0.0	0.1	-0.1	-0.2	-0.3
Ever depressed for a whole week	0.0	0.0	0.0	-0.2	-0.2	-0.1

Hub : Genes

HOXB6

Models

Trait associations