Hub : Genes

HOXB6

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Breast Invasive Carcinoma 0.0225 0.0125 0.0034 0.015 0.007 0.006 NA 0.008 0.00032 0.0110 0.020 NA 0.0075
2 TCGA Kidney Renal Clear Cell Carcinoma 0.0445 0.0217 0.0025 0.014 0.034 0.006 NA 0.009 0.00930 0.0001 0.067 NA 0.0320
3 TCGA Thyroid Carcinoma 0.0360 0.0210 0.0044 0.003 0.010 0.000 NA 0.006 0.14000 0.0330 0.340 NA 0.0790

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 1.0 1.7 0.5 1.3 1.0
Bipolar Disorder or Schizophrenia 0.3 0.8 2.0 0.2 0.5 1.4
Depressed Affect (Nagel 2018) 1.8 3.7 6.2 -0.6 -2.5 -2.1
Depression (Nagel 2018) 1.2 1.8 3.9 -1.0 -2.0 -0.7
Intelligence (Savage-Jansen 2018) 0.8 2.6 3.2 1.4 1.8 -1.6
Neuroticism (Nagel 2018) 1.1 2.5 5.2 -1.4 -2.3 -0.7
Schizophrenia (2018) 0.2 0.5 1.2 -0.1 -0.4 1.1
Schizophrenia vs Biploar Disorder 1.7 2.2 4.5 -1.3 -2.1 0.8
Worry (Nagel 2018) 0.6 1.3 2.1 -1.5 -1.3 0.5
Alzheimer’s Disease (in mother) 0.6 0.7 1.7 -0.7 -1.3 -0.3
Alzheimer’s Disease (in father) 1.2 1.3 2.6 0.2 -1.1 -1.6
Alzheimer’s Disease (including proxy) 0.8 1.1 2.7 -0.5 -1.6 -0.7
Crohns Disease (2017) 0.7 1.5 2.3 -1.4 -1.5 0.5
Irritable Bowel Disease (IBD) 0.6 1.5 3.2 -1.1 -1.8 -0.3
Ulcerative Colitis (UC) 0.9 1.7 3.8 -1.0 -1.9 -0.7
Major Depression (MDD) 0.5 0.7 1.3 0.3 -0.8 -1.1
Reaction Time 0.4 0.7 0.9 -1.0 -0.8 0.7
Verbal and Numeric Reasoning (VNR) 1.2 2.9 4.8 1.7 1.1 -2.2
Breast Cancer 0.1 0.3 0.5 0.7 0.4 -0.5
Ovarian Cancer 11.3 15.0 25.2 -5.0 -3.5 2.7
Prostate Cancer 1.2 1.7 2.6 1.6 0.4 -1.6
Age at First Birth 2.0 2.9 4.7 2.2 1.9 -0.5
Bipolar Disorder (2011) 0.1 0.1 0.3 -0.5 0.0 0.0
Body Mass Index (BMI) (2010) 1.9 2.6 4.8 -1.7 -0.5 2.2
Coronary Artery Disease (CAD) 1.0 1.2 2.3 -1.1 -1.5 -0.2
Crohns Disease (2012) 1.1 1.7 2.8 -1.7 -1.2 1.0
Mean Putamen Volume 0.4 0.5 1.0 1.0 0.7 -0.1
Fasting Glucose 2.1 2.5 5.4 1.1 2.3 -1.0
HbA1C 0.8 0.9 1.6 1.3 0.7 -0.8
HDL Cholesterol 0.0 0.1 0.2 0.4 0.3 0.1
LDL Cholesterol 2.4 3.9 5.9 -2.1 -1.1 2.4
Lupus 0.9 1.3 2.6 1.0 1.6 0.7
Neuroticism (2016) 0.4 0.6 1.2 0.1 -0.7 -1.1
Primary Biliary Cirrhosis 0.6 0.8 1.3 -1.2 -0.9 0.7
Rheumatoid Arthritis 3.2 4.3 8.5 2.1 0.4 -2.9
Schizophrenia (2014) 0.2 0.4 0.8 -0.0 -0.7 0.9
Triglycerides 0.7 1.2 2.1 0.1 -1.2 -1.4
Type 2 Diabetes (T2D) (2012) 3.8 4.4 5.2 2.3 2.1 -1.9
Ulcerative Colitis 0.1 0.1 0.2 -0.1 -0.5 -0.1
Blood Eosinophil Count 0.2 1.4 2.8 1.1 1.7 0.6
Blood Platelet Count 1.0 12.1 18.9 4.3 2.5 -3.3
Blood Red Count 5.2 49.9 66.6 -8.2 -7.0 5.9
Blood White Count 0.8 5.7 8.9 3.0 0.7 -2.8
Heel T-Score 0.1 0.4 0.7 0.1 0.8 0.8
BMI 1.5 8.9 20.2 -2.3 -1.0 4.5
Height 1.6 31.5 78.5 3.4 -2.1 -8.9
Waist Hip Ratio (WHR) 1.1 5.0 10.9 -2.0 -0.2 3.3
Systolic Blood Pressure 3.2 16.0 26.5 4.2 5.2 -1.9
Smoking Status 0.2 0.4 0.8 -0.4 -0.9 -0.6
Allergy or Eczema 0.8 2.2 3.0 -1.4 -1.7 1.2
Cardiovascular Disease 0.3 0.9 2.4 0.2 1.5 0.6
Hypothyroidism (self reported) 1.1 2.6 4.1 -1.9 -2.0 -0.6
Respiratory disease 2.2 5.0 9.9 -2.3 0.0 3.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.3 1.1 -0.4 -1.1
Lung FEV1/FVC ratio 1.3 6.6 13.3 2.2 1.2 -3.6
Lung FVC 4.2 21.2 38.7 -6.2 -3.7 3.4
Neuroticism 0.9 2.3 4.9 -1.1 -2.2 -0.8
Chronotype (morning person) 0.6 1.4 2.1 -1.1 0.9 1.5
Hair Pigment 0.1 3.0 6.4 0.2 -1.6 -2.5
Tanning 0.2 2.7 6.9 -0.9 0.6 2.6
Hand grip strength (left) 10.1 26.5 38.1 -6.2 -2.0 6.1
Number of treatments/medications taken 0.2 0.3 0.4 0.7 0.5 -0.3
Average weekly spirits intake 2.8 3.5 4.3 -2.1 -1.6 1.9
Sensitivity / hurt feelings 0.6 1.1 2.3 -0.2 -1.5 -0.9
Frequency of depressed mood in last 2 weeks 1.6 2.3 4.2 -1.5 -2.0 0.5
Hearing difficulty/problems: Yes 4.9 7.5 9.0 -3.0 -2.2 3.0
Relative age of first facial hair 0.3 0.6 1.5 0.3 -0.4 -1.2
Other serious medical condition/disability diagnosed by doctor 0.8 1.0 2.4 -0.7 -1.6 -0.2
Ever used hormone-replacement therapy (HRT) 1.6 2.1 3.1 1.8 1.3 -1.2
Ever had hysterectomy (womb removed) 0.7 0.8 1.9 0.2 -0.6 -1.4
Systolic blood pressure, automated reading 3.9 11.5 23.4 3.3 4.8 -0.0
Eye problems/disorders: Diabetes related eye disease 0.6 0.7 1.8 -0.4 -1.4 -0.3
Angina 2.3 3.0 3.7 1.7 1.6 -1.9
Medication for hormone replacement therapy 1.6 1.8 2.7 1.6 0.3 -1.6
Vitamin and mineral supplements 0.0 0.1 0.1 0.3 0.0 0.2
Supplements: Zinc 0.4 0.4 1.0 -0.4 -0.4 1.0
Medication: Co-codamol 0.5 0.5 1.2 0.6 0.1 -1.1
Medication: Metformin 1.6 2.2 4.0 2.0 0.9 -1.4
Diabetes (father) 1.4 1.8 4.4 -0.6 -2.1 -0.8
Diabetes (mother) 0.1 0.1 0.2 0.2 -0.5 -0.3
Severe depression (siblings) 0.6 0.6 1.0 0.9 0.2 -1.0
Pack years adult smoking proportion 0.4 0.7 1.0 0.4 0.9 1.0
Impedance of leg (right) 1.2 5.9 8.6 2.6 1.6 -2.9
Leg fat-free mass (left) 0.5 2.8 4.1 -1.8 -2.0 1.0
Trunk fat percentage 0.1 0.4 1.2 0.3 -0.2 1.1
Hand grip strength (right) 8.9 24.2 36.0 -6.0 -2.6 5.5
Townsend deprivation index at recruitment 1.7 2.4 6.2 -0.7 0.7 2.5
Current tobacco smoking 0.1 0.2 0.6 -0.1 -0.8 -0.4
Average weekly fortified wine intake 0.2 0.3 0.7 0.2 0.8 -0.3
Maternal smoking around birth 1.0 1.5 2.5 1.2 -0.8 -1.6
Fed-up feelings 1.7 3.0 7.1 -1.1 -2.7 -0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 2.0 -1.0 -1.4 0.0
Relative age voice broke 0.2 0.3 0.5 0.3 -0.7 -0.7
Taking other prescription medications 0.0 0.0 0.1 0.2 -0.2 0.3
Age when periods started (menarche) 1.3 3.0 5.8 1.8 0.2 -2.4
Bilateral oophorectomy (both ovaries removed) 2.2 2.6 5.4 1.5 -0.4 -2.3
Heel bone mineral density (BMD) T-score, automated (left) 0.0 0.1 0.2 -0.4 0.0 -0.1
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.8 -0.8 -0.4 0.9
Qualifications: CSEs or equivalent 0.4 0.5 1.4 -0.5 -1.2 -0.2
Serious illness, injury or assault to yourself 1.4 1.7 3.5 -1.2 -1.9 0.2
High blood pressure 1.0 2.7 5.1 1.6 2.3 -0.7
Hayfever, allergic rhinitis or eczema 1.4 3.1 3.5 -1.8 -1.6 1.9
Multivitamins +/- minerals 0.6 0.8 0.9 1.0 0.8 -0.9
Stomach or abdominal pain in last month 0.9 1.2 2.0 -0.7 -1.4 -1.0
Supplements: Glucosamine 0.9 1.1 2.2 1.5 1.1 -0.1
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 2.9 0.9 0.4 -1.7
Medication: Atenolol 0.6 0.8 1.9 0.6 1.4 -0.2
Medication: Levothyroxine sodium 2.2 3.7 5.9 -2.4 -2.3 0.1
Sitting height 2.4 16.9 43.0 2.6 -1.0 -6.6
Chronic bronchitis/emphysema (father) 1.9 2.2 4.1 2.0 0.5 -1.5
High blood pressure (mother) 0.2 0.3 0.5 -0.4 -0.7 -0.6
Body mass index (BMI) 1.9 8.0 19.7 -2.0 -0.4 4.4
Impedance of leg (left) 1.7 8.1 12.3 3.1 1.5 -3.5
Leg predicted mass (left) 0.5 2.9 4.4 -1.8 -2.1 1.0
Trunk fat mass 0.1 0.4 1.0 0.1 -0.4 1.0
Waist circumference 2.5 9.3 23.5 -2.1 -0.3 4.8
Number of incorrect matches in round 0.8 1.4 2.5 1.2 0.6 -1.6
Past tobacco smoking 0.0 0.1 0.1 -0.1 -0.4 -0.2
Alcohol usually taken with meals 0.6 0.9 2.2 0.5 0.6 -1.5
Nervous feelings 0.1 0.2 0.5 0.1 0.5 0.7
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 2.6 -1.4 -1.6 0.2
Hearing difficulty/problems with background noise 1.0 1.6 2.6 -1.2 -1.6 0.9
Hair/balding pattern: Pattern 2 0.1 0.2 0.4 -0.7 -0.3 -0.1
Had menopause 0.6 0.8 1.0 0.9 1.0 -0.8
Had other major operations 1.2 1.4 2.8 -1.2 -0.3 1.7
Forced vital capacity (FVC) 1.5 5.9 8.9 -2.8 -3.0 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.5 -0.7 -0.7 -0.0
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.7 0.6 0.0 -1.6
Qualifications: None of the above 0.1 0.1 0.2 0.2 0.5 -0.4
Financial difficulties in last 2 years 1.7 2.3 4.4 -1.5 -2.1 0.4
Mouth/teeth dental problems 1.2 1.8 2.6 1.6 1.6 -0.7
Heart attack 0.2 0.3 0.6 -0.4 -0.4 -0.8
Allergy 2.7 6.1 7.6 2.8 2.0 -2.6
Pain all over the body in last month 0.8 0.9 2.0 -0.8 -1.4 -0.3
Diabetes (self-reported) 0.7 1.1 1.7 1.3 -0.3 -1.3
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 1.8 -0.8 -0.4 1.3
Medication: Ramipril 0.0 0.1 0.1 0.2 0.0 -0.4
Medication: Simvastatin 0.8 1.2 1.8 -0.5 1.2 1.4
Fluid intelligence score 1.0 2.1 4.9 1.2 -0.3 -2.2
Illnesses of siblings 1.3 1.8 2.8 -1.7 -1.5 0.6
Neuroticism score 0.9 1.9 4.0 -1.3 -2.0 0.1
Weight 0.4 1.7 2.3 -1.2 -1.2 1.5
Impedance of arm (right) 1.9 8.9 16.6 3.1 0.8 -4.1
Arm fat percentage (right) 0.8 3.1 8.9 -0.7 -0.1 3.0
Trunk fat-free mass 0.2 1.3 2.0 -1.3 -1.4 0.2
Hip circumference 0.8 3.7 7.0 -1.7 -1.1 2.6
Time employed in main current job 0.3 0.4 0.6 -0.8 -0.7 -0.3
Alcohol intake versus 10 years previously 0.5 0.7 1.3 0.8 1.1 0.3
Father’s age at death 0.4 0.5 1.5 0.3 -0.1 -1.2
Worrier / anxious feelings 0.7 1.4 1.8 -1.4 -0.9 1.3
Frequency of tiredness / lethargy in last 2 weeks 2.7 4.4 6.7 -2.2 -2.6 1.2
Falls in the last year 0.6 0.8 1.2 0.2 -1.1 -1.1
Hair/balding pattern: Pattern 3 0.5 0.7 1.6 -0.1 0.6 1.3
Number of live births 0.5 0.7 1.2 -1.1 -0.8 0.5
Forced expiratory volume in 1-second (FEV1) 1.5 5.2 7.7 -2.8 -2.7 -0.9
Pulse rate 0.4 0.7 1.0 -0.8 -1.0 0.6
Happiness 1.7 2.0 2.7 -1.6 -1.6 0.9
Noisy workplace 0.2 0.2 0.4 -0.5 -0.1 0.7
Qualifications: A levels/AS levels or equivalent 0.4 0.9 1.4 1.2 0.9 -0.8
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.4 2.5 1.2 0.6 -1.6
Mouth/teeth dental problems: Dentures 3.9 6.6 10.0 -2.9 -3.2 1.1
Asthma 1.7 3.3 7.1 -1.7 0.3 2.7
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.7 1.4 -0.6 -1.2 -0.6
Medication: Cholesterol lowering 0.4 0.6 0.9 -0.4 0.9 0.9
Depression (self-reported) 0.9 1.1 3.1 0.1 -0.4 -1.8
Medication: Lansoprazole 1.3 1.4 1.7 1.3 1.0 -1.3
Prospective memory result 0.7 0.9 2.0 0.6 1.4 0.5
Lung cancer (father) 0.4 0.5 1.0 -0.1 -0.7 -1.0
Illnesses of mother 0.7 0.9 1.5 0.4 1.2 1.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.4 7.6 11.8 -3.4 -3.2 -0.8
Pulse wave Arterial Stiffness index 4.0 4.7 7.5 2.5 0.6 -2.7
Impedance of arm (left) 1.4 6.4 13.9 2.3 -0.0 -3.7
Arm fat mass (right) 0.7 3.1 7.2 -1.2 -0.7 2.7
Trunk predicted mass 0.2 1.3 2.1 -1.3 -1.4 0.2
Standing height 1.5 14.4 36.5 1.3 -2.2 -6.0
Length of working week for main job 0.4 0.4 0.8 -0.6 -0.9 0.4
Exposure to tobacco smoke at home 0.7 0.8 1.6 0.2 -1.3 -0.9
Breastfed as a baby 0.3 0.3 0.5 0.7 0.4 -0.6
Tense / ‘highly strung’ 1.4 2.4 3.4 -1.8 -1.8 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 0.9 0.1 -0.6 -1.0
Hair/balding pattern: Pattern 4 0.2 0.4 0.9 0.5 1.0 0.1
Birth weight of first child 0.7 1.4 2.4 0.3 1.3 1.6
Peak expiratory flow (PEF) 4.0 9.2 14.9 3.2 1.6 -3.9
Pulse wave reflection index 1.0 1.2 2.8 0.8 -0.5 -1.7
Ever highly irritable/argumentative for 2 days 0.5 0.6 1.4 0.3 -0.5 -1.2
Loud music exposure frequency 0.1 0.1 0.3 -0.0 0.6 0.3
Qualifications: O levels/GCSEs or equivalent 0.1 0.1 0.3 -0.5 -0.2 0.3
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.1 -0.8 -1.0 0.3
Blood clot in the leg (DVT) 3.6 4.7 9.9 -2.0 -3.1 -0.4
Medication: Paracetamol 0.3 0.6 0.9 0.8 -0.3 -1.0
Headache pain in last month 1.7 3.0 7.2 -1.3 -2.7 0.0
Medication for cholesterol, blood pressure or diabetes 0.6 0.9 1.7 -0.9 -1.3 0.5
Glaucoma (self-reported) 3.1 3.7 5.8 -2.3 -2.4 0.4
Gout (self-reported) 0.3 0.5 1.0 0.6 1.0 0.2
Hypothyroidism/myxoedema (self-reported) 1.6 3.2 4.8 -2.2 -2.2 -0.1
Medication: Amlodipine 1.1 1.5 2.1 1.4 1.4 -0.8
Medication: Ventolin 100micrograms inhaler 3.3 4.2 8.4 -1.8 -1.1 2.9
Birth weight 0.1 0.2 0.4 -0.2 0.5 0.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 1.4 0.2 -1.2 -0.9
High blood pressure (siblings) 0.5 0.8 1.4 0.8 0.5 -1.2
Forced vital capacity (FVC), Best measure 2.3 8.2 12.7 -3.6 -3.4 -0.9
Body fat percentage 0.3 1.2 3.6 0.0 0.1 1.9
Leg fat percentage (right) 1.1 3.9 10.7 -0.6 0.8 3.3
Arm fat-free mass (right) 0.4 2.3 3.1 -1.8 -1.7 0.9
Exposure to tobacco smoke outside home 4.6 6.1 11.6 -2.0 -1.6 3.4
Comparative body size at age 10 2.7 7.5 17.3 -0.6 2.2 4.2
Number of full brothers 0.9 1.1 2.4 -0.9 -1.6 0.4
Worry too long after embarrassment 4.1 6.8 12.7 -2.6 -3.6 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 0.9 1.3 -1.1 -1.1 0.2
Wheeze or whistling in the chest in last year 3.2 5.8 12.8 -2.0 -0.6 3.6
Number of children fathered 2.2 2.5 4.2 -2.1 -1.2 1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.1 -0.3 0.1 0.3
Age at first live birth 0.7 1.3 2.2 1.3 1.5 0.1
Pulse wave peak to peak time 3.8 4.5 7.0 -2.6 -1.0 2.4
Health satisfaction 6.6 8.6 12.0 -3.5 -2.8 2.5
Shortness of breath walking on level ground 0.9 1.0 1.8 -1.1 -1.3 0.4
Qualifications: College or University degree 0.8 2.6 3.0 1.7 1.4 -1.6
Eye problems/disorders: None of the above 0.7 0.8 1.4 0.9 0.3 -1.2
Mouth/teeth dental problems: Loose teeth 3.6 4.3 6.4 2.5 1.4 -2.1
Emphysema/chronic bronchitis 1.1 1.2 2.1 -1.2 -1.5 0.3
Medication for pain relief, constipation, heartburn 0.7 1.1 2.2 0.8 1.5 0.8
Neck or shoulder pain in last month 0.1 0.2 0.3 0.5 -0.3 -0.4
Medication: Blood pressure 1.1 1.9 2.4 1.6 1.5 -1.1
Angina (self-reported) 2.1 2.7 4.0 1.5 1.3 -2.0
Migraine (self-reported) 3.5 4.4 8.7 -2.0 -3.0 -0.8
Medication: Ibuprofen 0.9 1.1 2.3 -1.0 -1.5 -0.1
Medication: Allopurinol 0.9 1.2 2.2 1.1 1.5 0.4
Medication: Omeprazole 0.6 0.7 1.1 0.3 1.0 0.9
Medication: Seretide 50 evohaler 0.6 0.7 1.6 -0.8 -1.3 -0.1
Mean time to correctly identify matches 0.1 0.2 0.5 -0.7 0.1 0.4
Heart disease (mother) 0.5 0.6 1.0 -0.8 -1.0 -0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.2 2.6 4.6 -1.8 0.2 2.1
Whole body fat mass 0.2 1.0 2.7 -0.3 -0.4 1.6
Leg fat mass (right) 0.8 3.0 8.2 -0.8 0.1 2.9
Arm predicted mass (right) 0.6 3.3 4.4 -2.1 -2.1 1.0
Pulse rate, automated reading 0.7 2.3 5.2 -0.2 1.3 2.3
Alcohol intake frequency. 0.2 0.5 1.4 -0.2 0.2 1.2
Comparative height size at age 10 0.5 3.0 7.8 0.1 -1.1 -2.8
Number of full sisters 0.2 0.3 0.6 -0.3 0.3 0.8
Suffer from ‘nerves’ 0.4 0.6 1.7 0.3 -0.4 -1.3
Overall health rating 4.4 9.4 11.1 -3.3 -3.0 2.8
Chest pain or discomfort 2.2 3.2 4.6 -2.1 -2.0 0.9
Had major operations 0.3 0.4 0.7 0.5 -0.4 -0.9
Age at last live birth 1.0 1.4 2.4 1.4 1.6 0.3
Family relationship satisfaction 3.2 4.0 6.1 -2.4 -2.5 0.5
Leg pain on walking 0.2 0.3 0.5 -0.4 -0.3 0.7
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 1.5 -1.2 -0.4 1.0
Commuting to job workplace: Car/motor vehicle 0.6 0.7 1.2 -0.0 -1.0 -1.1
Illness, injury, bereavement, stress in last 2 years 2.3 2.8 4.1 1.9 2.0 -0.6
Medication: Aspirin 0.4 0.6 1.4 0.4 0.4 -1.2
Supplements: Vitamin C 0.3 0.3 0.8 -0.1 0.2 0.9
Knee pain experienced in last month 0.1 0.2 0.4 0.0 -0.5 0.6
Hypertension (Self-reported) 0.6 1.7 2.8 1.3 1.7 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.7 -0.1 0.5 1.3
Illnesses of father: Heart disease 0.0 0.0 0.1 -0.1 -0.2 -0.3
Illnesses of siblings: Diabetes 5.0 6.1 10.6 3.3 2.5 -1.2
Smoking status: Previous 0.1 0.1 0.3 -0.2 0.3 0.5
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.7 6.8 -1.6 -2.6 -1.2
Whole body fat-free mass 0.4 2.0 3.1 -1.6 -1.8 0.6
Leg fat-free mass (right) 0.5 2.7 4.8 -1.7 -2.2 0.7
Arm fat percentage (left) 0.9 3.6 9.5 -1.1 -0.5 3.1
Average weekly red wine intake 0.5 0.7 1.3 -0.9 0.0 1.1
Handedness (chirality/laterality): Left-handed 0.1 0.2 0.4 0.4 0.6 0.1
Mood swings 0.2 0.4 0.9 -0.3 -1.0 -0.5
Loneliness, isolation 0.2 0.2 0.5 -0.2 -0.7 -0.4
Long-standing illness, disability or infirmity 0.9 1.4 1.8 -1.2 -1.0 1.4
Ever had bowel cancer screening 4.5 5.3 6.8 2.4 1.8 -2.6
Diabetes diagnosed by doctor 0.9 1.5 2.9 1.7 0.1 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 0.9 0.9 1.6 -0.1 -1.2 -1.1
Friendships satisfaction 0.3 0.4 0.7 -0.8 -0.8 -0.0
Qualifications: nursing, teaching 0.8 1.3 2.0 1.4 0.2 -1.4
Commuting to job workplace: Walk 1.5 1.6 2.5 -1.5 -0.1 1.6
Eye problems/disorders: Cataract 0.6 0.7 1.7 -0.2 0.7 1.3
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.2 -0.2 -0.5 0.1
Medication for cholesterol 0.6 0.8 1.6 -0.9 -1.3 0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 4.4 -1.5 -2.1 -0.4
Back pain experienced in last month 1.8 2.6 5.4 -0.7 -2.3 -1.4
Mineral and other dietary supplements 0.6 0.8 1.8 -0.5 -1.4 -0.6
Breast cancer (self-reported) 0.1 0.1 0.1 0.4 0.4 -0.4
Asthma (self-reported) 1.8 3.6 8.0 -1.6 0.4 2.8
Osteoporosis (self-reported) 0.3 0.4 0.9 0.5 -0.0 -0.9
Osteoarthritis (self-reported) 0.3 0.4 0.8 0.2 0.7 0.9
Medication: Aspirin 0.5 0.6 1.8 0.3 0.0 -1.3
Medication: Gliclazide 2.0 2.2 5.7 1.0 -0.1 -2.4
Illnesses of father: None of the above (group 1) 1.8 2.2 3.5 0.4 1.9 1.8
Smoking status: Current 0.1 0.1 0.2 0.1 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.6 7.6 13.4 -3.7 -2.8 1.2
Whole body water mass 0.4 2.4 3.6 -1.8 -1.9 0.7
Leg predicted mass (right) 0.5 2.9 5.1 -1.8 -2.2 0.7
Arm fat mass (left) 0.8 3.4 7.3 -1.4 -1.0 2.7
Number of self-reported non-cancer illnesses 0.7 1.3 1.8 -1.3 -0.5 1.4
Average weekly champagne plus white wine intake 1.1 1.5 2.7 1.3 0.4 -1.6
Miserableness 0.4 0.7 1.6 -0.3 -1.3 -0.6
Guilty feelings 2.1 3.2 4.3 -2.1 -1.5 1.8
Wears glasses or contact lenses 0.9 1.0 2.5 -0.1 1.6 0.8
Ever taken oral contraceptive pill 0.6 0.6 1.4 0.7 0.2 -1.2
Hearing aid user 1.0 1.2 1.8 -1.1 -1.3 0.6
Mother’s age at death 0.1 0.1 0.2 0.0 0.0 -0.4
Financial situation satisfaction 5.1 6.3 8.2 -2.8 -2.9 1.7
Tinnitus: Yes, now most or all of the time 5.1 5.9 8.6 -2.9 -2.4 1.9
Commuting to job workplace: Public transport 0.3 0.4 0.9 -0.5 -0.1 1.0
Eye problems/disorders: Glaucoma 2.0 2.4 3.9 -1.8 -2.0 0.5
Medication: Blood pressure 0.4 0.8 1.6 0.8 1.2 -0.3
Pain type(s) experienced in last month: Hip pain 2.6 3.3 5.4 -2.0 -2.3 0.6
Supplements: Fish oil (including cod liver oil) 1.1 1.4 2.2 -0.0 1.4 1.5
High cholesterol (Self-reported) 1.4 2.5 4.2 -1.8 0.2 2.1
Medication: Bendroflumethiazide 0.9 1.4 3.4 0.9 -0.1 -1.8
Medication: Paracetamol 0.4 0.6 1.8 -0.4 -1.3 0.0
Medication: Lisinopril 1.1 1.4 2.0 1.0 1.4 -1.1
Medication: Atorvastatin 0.5 0.7 1.1 -0.8 0.5 1.1
Illnesses of father: High blood pressure 1.0 1.3 1.9 -1.4 -1.4 -0.2
Alcohol drinker status: Never 1.3 1.6 1.9 -1.4 -1.4 1.0
Ever smoked 0.1 0.2 0.4 0.5 0.7 -0.1
Basal metabolic rate 0.4 2.3 3.1 -1.6 -1.8 1.0
Leg fat percentage (left) 0.8 2.8 7.9 -0.3 0.7 2.8
Arm fat-free mass (left) 0.4 2.0 2.6 -1.6 -1.6 0.9
Number of operations (self-reported) 0.5 0.8 1.4 1.2 0.2 -1.0
Average weekly beer plus cider intake 0.9 1.3 2.8 1.7 0.7 -0.8
Irritability 0.6 1.1 1.6 -1.2 -1.3 0.5
Risk taking 1.4 2.1 4.3 0.3 -1.4 -2.1
Ever had prostate specific antigen (PSA) test 1.0 1.2 2.6 0.9 -0.3 -1.6
Fractured/broken bones in last 5 years 0.7 1.0 1.8 1.3 0.4 -1.0
Age started oral contraceptive pill 0.1 0.1 0.1 -0.4 0.1 0.3
Diastolic blood pressure, automated reading 0.5 1.6 3.5 -1.2 -0.0 1.9
Ever depressed for a whole week 0.0 0.0 0.0 -0.2 -0.2 -0.1
Unable to work because of sickness or disability 0.2 0.2 0.4 0.5 0.7 0.1
Commuting to job workplace: Cycle 0.4 0.5 1.1 0.6 -0.1 -1.1
Myopia 0.1 0.2 0.5 0.1 0.7 -0.0
Vascular/heart problems diagnosed by doctor 0.6 1.6 2.9 -1.2 -1.7 0.8
Cholesterol lowering medication 1.8 2.6 4.7 -0.1 2.2 1.8
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 -0.1 0.5 0.8
Pain experienced in last month 1.8 3.0 6.9 1.4 2.6 0.5
Supplements: Calcium 0.4 0.4 1.0 0.4 1.0 0.2
Basal cell carcinoma (self-reported) 2.8 3.4 4.5 -2.1 -1.6 1.8
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.8 -0.3 -0.4 -0.9
Deep venous thrombosis (DVT) (self-reported) 3.4 4.4 9.5 -1.7 -3.1 -0.9
Heart disease (siblings) 0.1 0.1 0.2 -0.1 0.4 -0.3
Alcohol drinker status: Previous 0.9 1.0 1.7 0.4 -1.1 -1.3
Pack years of smoking 0.3 0.4 0.8 0.6 0.9 0.4
Impedance of whole body 2.0 10.0 20.0 3.1 0.6 -4.5
Leg fat mass (left) 0.6 2.4 6.6 -0.7 0.0 2.6
Arm predicted mass (left) 0.3 1.4 2.0 -1.3 -1.4 0.7