TWAS hub - TMEM43

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1000	0.0300	4.4e-05	0.012	0.032	0.011	0.027	0.008	1.2e-02	8.4e-05	1.6e-02	2.4e-04	3.4e-02
2	GTEx	Artery Tibial	0.1193	0.0422	1.2e-03	0.017	NA	0.002	NA	0.016	1.5e-02	NA	2.2e-01	NA	1.9e-02
3	GTEx	Esophagus Muscularis	0.0940	0.0380	6.6e-03	0.029	NA	0.042	NA	0.032	7.0e-03	NA	1.5e-03	NA	5.0e-03
4	GTEx	Heart Left Ventricle	0.1642	0.0575	3.5e-03	0.005	NA	-0.005	NA	-0.004	1.6e-01	NA	7.9e-01	NA	5.7e-01
5	METSIM	Adipose	0.0581	0.0235	4.2e-03	0.007	0.016	0.009	0.015	0.011	2.8e-02	1.4e-03	1.6e-02	1.9e-03	6.4e-03
6	YFS	Blood	0.0494	0.0141	2.2e-05	0.013	0.011	0.012	0.018	0.018	2.2e-05	1.0e-04	6.4e-05	8.7e-07	7.6e-07
7	TCGA	Pancreatic Adenocarcinoma	0.1870	0.0830	5.4e-03	0.073	0.017	0.008	NA	0.034	5.5e-04	6.3e-02	1.5e-01	NA	1.5e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Length of working week for main job	3.4	3.7	10.1	0.7	0.7	2.3	2.2	0.7	3.2	2.0
Forced vital capacity (FVC)	2.9	11.3	21.3	4.6	2.4	3.7	-2.1	4.2	2.8	2.9
Forced expiratory volume in 1-second (FEV1)	2.9	9.7	31.6	5.6	2.0	2.9	-1.6	3.8	1.2	2.3
Ever depressed for a whole week	2.9	3.6	10.9	2.2	-0.1	0.1	0.6	3.3	2.8	0.8
Tinnitus: Yes, now most or all of the time	2.6	3.1	9.3	-0.8	-1.8	-0.9	-3.0	0.9	2.3	1.2
Trunk fat-free mass	2.5	14.1	24.1	4.9	2.1	4.0	-3.2	4.9	3.9	2.3
Trunk predicted mass	2.5	14.1	23.8	4.9	2.1	4.0	-3.2	4.8	3.9	2.3
Birth weight of first child	2.5	4.5	7.1	-2.5	-2.6	-1.9	-2.7	1.1	2.5	-0.7
Hayfever/allergic rhinitis (self-reported)	2.4	3.1	9.9	-1.4	0.2	0.2	3.1	-2.0	-2.2	0.9
Past tobacco smoking	2.3	4.2	8.8	-0.9	3.0	2.4	2.2	0.0	-2.9	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.3	4.8	9.8	2.8	3.1	3.1	0.2	2.0	-1.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.6	5.7	-0.0	-1.1	-2.4	1.6	-1.8	-1.1	-2.0
Exposure to tobacco smoke at home	2.2	2.4	10.8	0.8	-1.7	-0.4	0.4	0.9	3.3	-1.4
Smoking status: Previous	2.2	3.3	6.5	0.0	-2.5	-2.0	-2.4	0.0	2.5	-0.8
Whole body fat-free mass	2.2	12.8	21.9	4.5	2.2	3.6	-3.1	4.7	3.8	2.4
Whole body water mass	2.2	12.4	21.1	4.5	2.1	3.6	-3.0	4.6	3.7	2.3
Forced vital capacity (FVC), Best measure	2.1	7.6	19.8	4.5	2.0	2.9	-1.6	3.2	1.9	2.1
Family relationship satisfaction	2.1	2.6	7.3	-0.8	-2.0	-2.7	-1.0	-1.9	-1.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.4	8.2	-2.9	0.6	0.5	1.8	-1.4	-1.3	1.2
Miserableness	2.1	3.7	9.7	0.4	-1.6	-1.3	-2.7	2.1	3.1	0.6
HbA1C	2.0	2.2	9.0	0.2	1.1	0.4	3.0	0.7	-1.1	1.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.4	25.8	5.1	1.8	2.2	-1.1	2.6	0.9	1.5
Arm fat-free mass (right)	2.0	10.1	19.8	3.7	1.2	2.6	-3.0	4.5	3.9	2.1
Arm predicted mass (right)	2.0	10.3	21.5	3.7	1.0	2.6	-2.8	4.6	4.2	2.0
Mood swings	2.0	3.5	10.1	-0.1	-2.4	-2.4	-1.5	0.8	3.2	-0.5
Long-standing illness, disability or infirmity	2.0	3.0	8.6	-0.7	1.1	1.4	-0.9	1.8	2.2	2.9
Arm predicted mass (left)	2.0	10.0	19.4	3.8	0.9	2.4	-2.8	4.4	4.1	2.2
Height	1.9	35.8	130.0	11.4	2.7	5.5	-1.5	6.2	6.5	0.1
Impedance of leg (left)	1.9	9.1	19.1	-0.3	-4.1	-4.4	4.4	-2.1	1.0	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	7.7	-1.9	-1.2	-1.0	-0.6	2.8	1.9	2.0
Pain type(s) experienced in last month: Hip pain	1.9	2.4	5.2	1.3	1.5	1.8	-2.3	2.1	0.4	-0.3
Arm fat-free mass (left)	1.9	9.4	18.5	3.7	0.8	2.4	-2.7	4.3	4.0	2.1
Frequency of depressed mood in last 2 weeks	1.8	2.5	7.1	-1.8	-0.1	-0.4	-2.7	1.5	1.4	1.6
Hearing difficulty/problems: Yes	1.8	2.7	6.5	-1.6	-2.1	-1.0	-1.8	-0.6	2.6	1.1
Medication for hormone replacement therapy	1.8	2.0	6.9	0.5	0.4	1.2	0.2	2.6	1.0	2.1
Leg fat-free mass (left)	1.8	9.4	14.6	3.8	2.3	3.2	-2.7	3.8	3.1	2.1
Leg predicted mass (left)	1.8	9.4	14.7	3.8	2.3	3.1	-2.7	3.8	3.2	2.1
Standing height	1.8	17.9	68.4	8.3	1.4	2.9	-0.9	4.1	5.2	1.3
Blood clot in the leg (DVT)	1.8	2.4	4.7	-1.0	-2.2	-1.9	-1.2	0.6	2.0	-1.2
Knee pain experienced in last month	1.8	2.8	4.6	0.1	2.0	1.9	-1.9	2.1	0.8	1.7
Leg fat-free mass (right)	1.8	9.5	14.0	3.7	2.2	2.9	-3.2	3.7	3.2	2.3
Leg predicted mass (right)	1.8	9.6	14.7	3.8	2.2	2.9	-3.1	3.8	3.2	2.2
Ever smoked	1.8	3.2	9.9	0.2	-3.1	-2.7	-0.9	-0.5	2.0	-0.4
Basal metabolic rate	1.8	10.2	17.9	4.0	1.7	3.0	-2.8	4.2	3.7	2.1
Deep venous thrombosis (DVT) (self-reported)	1.8	2.3	5.0	-0.7	-2.2	-1.8	-1.3	0.5	1.9	-1.2
Happiness	1.7	2.1	6.2	0.1	0.3	-0.1	-2.4	1.5	0.7	2.5
Impedance of leg (right)	1.6	7.8	21.4	-0.2	-3.5	-3.6	4.6	-1.8	0.7	-2.1
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	6.0	-1.5	-1.0	-1.1	0.5	-1.1	-2.5	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.2	-0.1	-1.2	-2.3	0.3	-2.0	-0.7	1.6
Ever highly irritable/argumentative for 2 days	1.6	2.0	4.2	1.4	-0.8	-0.4	-1.3	1.5	2.1	1.7
Comparative height size at age 10	1.6	9.0	24.1	4.9	2.1	3.1	-1.5	2.6	3.8	1.6
Hearing aid user	1.6	1.8	5.9	-2.4	-1.8	-1.0	-0.6	-1.0	0.9	0.2
Unable to work because of sickness or disability	1.6	2.1	6.7	-0.5	0.3	0.6	0.6	1.6	2.6	2.0
Smoking Status	1.5	3.5	9.7	-0.0	-3.0	-3.1	0.9	-0.8	1.9	-1.1
Breastfed as a baby	1.5	1.9	5.4	1.1	1.1	0.0	2.0	-1.3	-2.3	-0.1
Heart disease (mother)	1.5	1.8	5.1	-0.6	-1.2	-1.4	-1.3	2.3	1.2	0.8
Impedance of whole body	1.5	7.4	17.0	-0.1	-2.7	-3.8	4.1	-3.0	-0.3	-2.0
Depressed Affect (Nagel 2018)	1.4	2.9	9.5	-0.0	-1.1	-0.7	-2.4	1.5	3.1	0.9
Neuroticism	1.4	3.5	9.1	-0.1	-0.8	-0.4	-1.9	3.0	2.9	1.4
Supplements: Glucosamine	1.4	1.9	6.2	1.1	1.9	0.9	-0.6	-0.7	-2.5	0.4
Sitting height	1.4	10.2	26.1	3.8	-0.6	1.2	-1.9	4.3	5.1	2.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.3	-1.7	-0.4	-0.7	-2.1	1.7	1.3	1.7
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.1	12.0	-0.9	-0.9	-1.0	-1.6	-0.6	-2.0	-3.5
Neuroticism score	1.4	2.9	5.8	-0.3	-1.4	-1.2	-2.4	2.3	2.4	0.5
Medication: Lansoprazole	1.4	1.6	5.2	-2.3	0.9	0.7	-0.5	-0.9	0.7	1.7
Illnesses of mother	1.4	1.8	3.7	1.9	1.7	1.7	1.5	-0.2	-0.5	0.6
Medication: Ibuprofen	1.4	1.6	4.0	-1.0	-1.3	-2.0	0.1	-1.5	-0.1	1.6
Medication: Seretide 50 evohaler	1.4	1.6	4.4	2.1	0.1	0.9	0.1	1.0	2.1	-0.8
Number of full sisters	1.4	1.7	5.9	-1.6	0.1	0.1	1.8	-0.5	-2.4	0.2
Average weekly beer plus cider intake	1.4	2.0	5.1	0.5	-2.0	-1.5	-0.6	-1.4	2.2	-0.1
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.6	0.2	1.4	2.4	1.1	1.1	1.0	1.1
Basal cell carcinoma (self-reported)	1.4	1.7	4.1	-2.0	-0.1	-0.7	-1.3	-1.3	-1.4	-1.3
Reaction Time	1.3	2.4	6.9	-0.8	0.6	0.6	0.2	1.5	2.6	2.5
Triglycerides	1.3	2.1	4.7	2.2	1.4	1.8	0.2	0.4	-0.4	2.1
Chronotype (morning person)	1.3	3.1	13.5	3.7	1.6	1.0	0.6	-0.5	-1.2	-1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	7.4	-0.3	1.2	0.9	-1.3	-0.2	0.4	2.7
Fed-up feelings	1.3	2.3	8.5	0.1	-0.2	0.3	-1.5	1.4	2.9	1.8
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.3	0.2	-1.6	-1.8	-1.2	1.0	1.7	-0.3
Heart attack	1.3	1.7	3.6	-1.6	1.3	1.2	-1.9	0.1	-1.5	0.4
Pulse rate	1.3	2.2	5.0	1.4	1.8	1.9	0.8	2.2	1.0	0.2
Depression (self-reported)	1.3	1.6	7.1	-0.5	-0.5	-0.7	-0.3	2.7	1.7	0.4
Peak expiratory flow (PEF)	1.3	3.0	9.5	3.1	0.9	1.2	-2.0	2.0	-1.2	0.4
Migraine (self-reported)	1.3	1.6	4.6	-1.0	-1.3	-1.3	1.2	-2.1	1.1	0.1
Medication: Allopurinol	1.3	1.7	3.9	-1.6	-0.1	-0.5	-0.2	1.2	1.8	2.0
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	10.5	3.2	0.2	0.9	-0.8	0.9	1.9	1.7
Ever had bowel cancer screening	1.3	1.6	6.4	-2.5	-0.3	0.1	-1.6	-0.4	1.3	-0.2
Mineral and other dietary supplements	1.3	1.7	4.5	-0.5	-2.1	-1.4	-0.6	1.2	1.4	1.2
Depression (Nagel 2018)	1.2	1.8	3.9	-1.2	-0.8	-1.1	-1.9	2.0	1.3	0.6
Prostate Cancer	1.2	1.7	5.2	-2.3	-0.2	-0.6	-1.9	-1.0	-0.7	1.1
Type 2 Diabetes (T2D) (2012)	1.2	1.4	5.2	0.9	-0.9	-1.1	-0.8	-1.0	0.4	2.3
Lung FVC	1.2	6.2	13.4	2.6	2.9	3.7	-2.4	2.9	-0.1	1.0
Diabetes (father)	1.2	1.5	5.5	0.5	0.9	1.6	2.3	0.1	0.7	0.9
Townsend deprivation index at recruitment	1.2	1.7	3.1	1.8	1.2	1.6	-0.7	1.4	1.4	0.8
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	9.6	0.1	-1.0	-1.6	-1.0	-0.8	-2.0	-3.1
High blood pressure (mother)	1.2	1.6	5.1	-1.6	-2.2	-1.6	0.6	-0.4	0.3	-0.6
Number of incorrect matches in round	1.2	1.9	5.1	1.5	0.2	1.0	-1.7	1.5	2.3	0.3
Nervous feelings	1.2	2.3	7.9	-1.3	-0.7	-0.8	-2.8	2.2	0.4	-0.6
Pain all over the body in last month	1.2	1.3	5.1	-0.9	0.7	0.8	-0.1	-1.3	0.8	2.3
Shortness of breath walking on level ground	1.2	1.4	3.4	1.3	0.4	0.8	-0.4	1.8	1.7	-0.8
Friendships satisfaction	1.2	1.5	4.2	1.5	-1.1	-0.8	-2.1	1.3	0.5	-0.2
Medication for cholesterol	1.2	1.8	4.6	1.2	-0.9	-1.4	0.0	-2.1	0.3	-1.9
Supplements: Calcium	1.2	1.3	3.3	-0.2	1.5	1.8	1.6	-0.7	-0.7	-0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.3	-1.6	1.3	1.1	-1.8	0.3	-1.4	0.4
Alcohol drinker status: Previous	1.2	1.3	3.0	0.2	1.1	1.1	-1.7	1.2	0.9	1.3
Worry (Nagel 2018)	1.1	2.4	10.5	0.8	0.5	0.5	-1.6	3.2	1.6	0.0
Alzheimer’s Disease (in father)	1.1	1.2	2.3	1.2	0.8	1.4	1.3	0.0	0.6	-1.5
Major Depression (MDD)	1.1	1.3	2.9	1.6	1.2	1.7	0.5	1.0	1.2	0.0
Ovarian Cancer	1.1	1.5	2.5	-0.7	-0.8	-1.2	1.3	-1.2	1.6	-1.6
Heel T-Score	1.1	9.1	25.2	-3.2	-1.9	-2.8	-2.9	-2.1	-5.0	-2.0
Hypothyroidism (self reported)	1.1	2.5	5.7	-1.3	-2.4	-1.4	-1.8	1.1	1.6	-1.0
Supplements: Zinc	1.1	1.2	2.4	-1.1	-1.1	-0.9	-1.0	-1.5	0.4	-1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	4.3	-0.4	-0.7	-0.3	-1.4	2.1	1.6	0.7
Serious illness, injury or assault to yourself	1.1	1.4	2.6	1.3	1.1	1.0	-0.1	1.6	1.6	0.7
Hair/balding pattern: Pattern 2	1.1	1.4	4.7	-0.0	0.8	0.7	-2.2	0.5	-1.6	-1.1
Impedance of arm (right)	1.1	5.0	12.1	-0.1	-1.1	-2.4	3.4	-3.5	-1.0	-1.8
Worrier / anxious feelings	1.1	2.1	7.6	0.4	0.0	0.3	-1.0	2.8	2.4	-0.1
Impedance of arm (left)	1.1	5.1	11.9	-0.0	-1.0	-2.5	3.5	-3.5	-1.1	-2.0
Pulse wave reflection index	1.1	1.4	2.9	-0.5	-1.7	-0.9	-1.4	0.2	1.5	-1.2
Chronic bronchitis/emphysema (mother)	1.1	1.3	3.7	0.3	1.7	1.3	-0.2	0.5	0.7	1.9
High blood pressure (siblings)	1.1	1.5	4.0	-1.2	0.4	0.7	1.1	-2.0	-1.7	-0.8
Exposure to tobacco smoke outside home	1.1	1.4	3.0	0.1	-1.5	-1.1	0.2	1.4	1.7	-1.4
Angina (self-reported)	1.1	1.5	3.2	0.2	-0.1	-0.0	-1.6	1.8	1.4	1.7
Illnesses of siblings: Diabetes	1.1	1.4	4.3	0.5	2.1	1.8	0.7	0.6	-0.8	0.3
Mouth/teeth dental problems: Mouth ulcers	1.1	1.7	5.6	0.8	-0.7	0.0	-2.2	0.3	2.4	0.3
Medication: Blood pressure	1.1	2.0	5.6	-0.5	2.4	2.0	-0.3	1.5	-0.7	1.1
Medication: Bendroflumethiazide	1.1	1.7	5.0	0.3	2.2	1.8	-0.8	0.4	-1.4	1.1
Mean Putamen Volume	1.0	1.1	3.6	-0.2	-0.6	-0.6	-0.7	0.6	1.9	1.6
Neuroticism (2016)	1.0	1.4	3.8	0.7	1.0	1.0	-1.5	1.9	-0.3	1.0
Respiratory disease	1.0	2.2	9.6	-2.0	0.5	0.6	-3.1	1.0	-0.3	-0.3
Average weekly spirits intake	1.0	1.2	5.5	0.6	0.8	0.5	2.4	0.8	0.9	0.4
Sensitivity / hurt feelings	1.0	1.7	5.1	-0.5	-0.5	-0.2	-0.9	2.1	2.3	1.1
Angina	1.0	1.3	2.7	0.1	0.2	0.1	-1.4	1.6	1.3	1.6
Medication: Omeprazole	1.0	1.2	4.9	-0.5	1.3	2.2	0.6	0.6	0.5	0.9
Pulse rate, automated reading	1.0	3.3	9.3	0.6	1.2	1.8	2.6	3.0	1.4	0.4
Suffer from ‘nerves’	1.0	1.5	6.8	-0.5	-0.9	-0.6	-0.8	2.6	1.3	-0.4
Back pain experienced in last month	1.0	1.5	4.3	-0.3	-1.1	-0.2	-2.1	1.5	1.4	-0.8
Osteoporosis (self-reported)	1.0	1.3	4.1	-0.6	-2.0	-1.7	-0.5	-0.1	1.1	-0.5
Financial situation satisfaction	1.0	1.2	4.2	-1.5	-0.8	-0.9	0.3	0.1	-0.9	2.0
Fractured/broken bones in last 5 years	1.0	1.3	5.4	0.4	-0.6	-0.5	0.8	1.2	2.3	1.0
Pain experienced in last month	1.0	1.7	5.0	1.4	-0.1	-0.6	2.2	-0.5	-1.5	-1.5
Neuroticism (Nagel 2018)	0.9	2.2	5.6	0.7	-0.1	0.0	-1.8	2.2	2.4	0.8
Lupus	0.9	1.4	4.5	-0.7	-0.6	-1.3	-1.1	-2.1	-1.1	0.2
Pack years adult smoking proportion	0.9	1.3	3.9	1.1	0.1	-0.1	1.9	-0.2	0.7	2.0
Current tobacco smoking	0.9	1.4	5.9	0.2	-0.7	-1.3	2.4	-0.7	0.8	-0.7
Hearing difficulty/problems with background noise	0.9	1.4	3.3	-0.8	-0.8	0.3	-1.7	1.4	1.8	0.4
Financial difficulties in last 2 years	0.9	1.2	3.8	-0.4	0.4	0.3	-0.4	1.9	0.2	1.9
Time employed in main current job	0.9	1.1	3.7	1.9	-1.0	-0.5	1.0	1.0	0.8	0.0
Loud music exposure frequency	0.9	1.0	1.9	1.3	0.8	1.4	0.1	1.3	1.0	0.0
Leg pain on walking	0.9	1.1	3.9	-0.2	-0.5	-0.2	-1.8	-0.1	2.0	-0.1
Eye problems/disorders: Glaucoma	0.9	1.1	2.5	0.9	-1.5	-1.6	-0.2	0.9	1.2	0.0
Commuting to job workplace: Cycle	0.9	1.1	4.8	0.3	0.3	-0.5	-0.6	-2.2	-0.9	1.1
Schizophrenia vs Biploar Disorder	0.8	1.0	3.3	0.5	-0.1	0.4	1.7	-0.2	0.5	1.8
Hand grip strength (left)	0.8	2.2	5.0	1.6	0.1	1.2	-2.2	1.5	2.1	0.3
Relative age of first facial hair	0.8	1.7	2.9	1.4	-1.6	-0.9	-0.5	1.2	1.7	-1.4
Systolic blood pressure, automated reading	0.8	2.2	4.9	-1.9	0.2	-0.8	-0.6	-2.2	-1.9	-1.6
Multivitamins +/- minerals	0.8	1.0	2.6	0.3	1.6	1.1	-0.3	-0.0	-1.5	-0.6
Diabetes (self-reported)	0.8	1.2	3.4	-0.0	-1.8	-1.8	-0.8	-1.0	-0.2	0.3
Mouth/teeth dental problems: Dentures	0.8	1.3	4.5	-0.4	-0.9	-0.7	-2.1	-0.4	0.9	1.5
Pulse wave Arterial Stiffness index	0.8	0.9	5.4	0.3	-0.0	0.6	0.5	-0.5	0.4	-2.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.5	-0.6	-1.4	-1.6	-0.7	1.5	0.7	-0.5
Headache pain in last month	0.8	1.3	4.3	-0.2	0.5	1.1	-1.3	0.6	2.1	1.1
Glaucoma (self-reported)	0.8	1.0	3.1	1.6	-0.6	-0.2	-0.4	1.8	0.8	0.5
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.0	-0.2	-1.1	-0.1	-1.5	2.2	1.6	-0.1
Number of full brothers	0.8	1.0	4.4	0.5	-0.2	0.2	-1.0	-1.1	0.3	-2.1
Pulse wave peak to peak time	0.8	1.0	5.2	0.5	0.2	-0.4	-0.7	0.8	-0.1	2.3
Mean time to correctly identify matches	0.8	1.5	7.0	-0.5	0.4	0.3	0.5	1.4	2.6	1.0
Overall health rating	0.8	1.7	7.3	-0.5	1.2	1.2	0.2	0.7	1.0	2.7
Loneliness, isolation	0.8	1.1	4.7	-0.6	-0.3	-0.4	-2.2	1.6	0.5	0.0
Commuting to job workplace: Walk	0.8	0.8	1.6	-0.8	-0.6	-0.8	-0.0	-1.3	-1.0	-1.2
Smoking status: Current	0.8	1.3	4.5	0.2	-0.9	-1.5	2.1	-0.7	0.8	-0.7
Leg fat percentage (left)	0.8	2.8	5.5	-2.3	-2.1	-1.9	1.4	0.1	1.9	-0.3
Age started oral contraceptive pill	0.8	1.0	2.1	0.7	1.5	1.4	0.2	0.1	-1.4	-0.9
Myopia	0.8	1.1	5.5	-0.5	0.6	0.5	0.6	2.3	0.5	-1.0
Bipolar Disorder (2018)	0.7	1.1	2.0	-0.4	-1.0	-1.2	-1.4	-1.0	-0.6	-1.4
Age at First Birth	0.7	1.0	3.5	-0.7	-0.6	-0.2	-0.9	1.4	1.9	-0.1
Body Mass Index (BMI) (2010)	0.7	0.9	3.1	1.2	0.2	0.8	-0.0	0.9	0.7	1.8
Crohns Disease (2012)	0.7	1.1	3.1	-1.8	0.1	0.1	1.5	-1.0	-0.1	1.1
Blood White Count	0.7	4.9	19.0	-3.8	0.1	0.0	4.4	0.8	0.3	-0.6
Lung FEV1/FVC ratio	0.7	3.6	18.7	4.3	-0.5	-1.2	1.2	0.4	-1.6	-1.0
Medication: Co-codamol	0.7	0.9	3.6	-0.5	-0.8	-0.6	-1.0	-0.3	0.3	-1.9
Diabetes (mother)	0.7	0.8	3.6	-1.5	-0.3	-0.0	1.9	-0.3	-0.3	0.0
Taking other prescription medications	0.7	1.1	3.1	-1.8	0.7	1.2	0.7	1.2	0.6	0.5
Qualifications: CSEs or equivalent	0.7	1.0	2.9	-0.1	-1.6	-1.7	0.5	-0.2	-0.8	0.6
Hayfever, allergic rhinitis or eczema	0.7	1.4	4.0	-0.8	-0.3	-0.8	-0.2	-1.9	-2.0	-1.0
Allergy	0.7	1.6	3.5	0.9	1.1	1.2	1.2	1.5	0.6	1.9
Weight	0.7	3.5	7.9	2.0	0.8	1.5	-1.4	2.5	2.8	1.1
Hip circumference	0.7	3.1	8.2	1.4	0.4	1.1	-1.4	2.6	2.9	1.1
Hair/balding pattern: Pattern 3	0.7	1.1	4.1	0.2	-1.1	-1.0	2.0	-0.5	0.9	-0.1
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.3	-0.7	-0.1	-0.8	-0.7	-1.8	-1.6	-0.1
Leg fat percentage (right)	0.7	2.5	5.7	-2.4	-1.8	-1.5	1.6	0.0	1.8	-0.6
Comparative body size at age 10	0.7	2.0	4.1	-1.9	-1.3	-1.2	-0.9	-2.0	-1.2	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.5	0.3	1.2	0.6	-0.4	1.6	-0.5	1.1
Health satisfaction	0.7	0.9	2.1	-1.4	-0.8	-0.9	-1.0	-0.3	0.1	1.2
Neck or shoulder pain in last month	0.7	0.9	2.1	-1.0	-1.4	-1.0	-1.3	0.6	0.7	-0.3
Chest pain or discomfort	0.7	1.0	3.0	-1.7	-0.5	-0.1	-0.8	0.1	0.6	1.5
Had major operations	0.7	0.9	2.0	1.4	0.6	0.5	0.5	1.1	1.4	0.2
Eye problems/disorders: Cataract	0.7	0.8	2.2	1.5	-0.8	-0.3	0.3	1.4	0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	2.5	0.4	0.7	1.2	-0.2	1.0	1.6	-0.1
Asthma (self-reported)	0.7	1.3	5.2	-1.6	-0.3	0.2	-2.3	1.1	0.3	-0.2
Medication: Gliclazide	0.7	0.8	1.6	0.7	-1.2	-0.8	-0.5	1.2	0.3	1.0
Wears glasses or contact lenses	0.7	0.8	3.3	-0.9	-0.0	0.0	0.0	-0.7	1.0	-1.8
High cholesterol (Self-reported)	0.7	1.2	5.1	-0.5	1.2	0.6	0.3	-0.3	-2.3	0.9
Pack years of smoking	0.7	1.1	2.7	1.3	0.4	0.3	1.6	-0.3	0.9	1.4
Coronary Artery Disease (CAD)	0.6	0.7	2.3	-1.5	-0.9	-0.9	-0.4	-0.6	-0.5	0.4
Fasting Glucose	0.6	0.8	3.0	1.3	0.3	0.3	-0.3	-0.4	-0.6	-1.7
Primary Biliary Cirrhosis	0.6	0.8	4.5	-0.1	-0.6	-0.3	-0.7	-0.1	0.5	2.1
Waist Hip Ratio (WHR)	0.6	2.9	5.7	-0.5	-0.4	-1.6	2.2	-2.3	-2.4	-1.2
Vitamin and mineral supplements	0.6	0.7	2.1	-0.6	-1.4	-1.2	-0.3	-0.5	0.9	0.2
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.6	0.0	-0.1	-1.2	0.3	-1.3	0.7	0.8
Stomach or abdominal pain in last month	0.6	0.7	1.7	0.4	0.9	1.1	-0.5	1.3	-0.2	0.8
Had other major operations	0.6	0.8	1.8	0.6	-0.8	-0.6	0.4	-1.3	0.4	1.3
Qualifications: None of the above	0.6	1.2	7.6	0.1	-0.1	1.0	-0.1	0.4	2.8	-0.1
Mouth/teeth dental problems	0.6	0.9	4.5	-0.5	-0.1	-0.2	2.1	-0.6	-0.2	-1.1
Medication: Simvastatin	0.6	0.9	2.7	-1.7	-0.0	-0.5	-1.4	-0.5	-0.4	1.0
Illnesses of siblings	0.6	0.8	2.3	1.1	0.5	0.2	-0.8	1.5	-0.2	1.0
Falls in the last year	0.6	0.8	1.6	-1.1	0.2	0.6	-0.8	-1.1	0.4	1.3
Number of live births	0.6	0.8	2.0	0.0	1.4	1.4	0.8	1.0	0.4	0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.3	3.8	-0.6	1.4	0.9	-0.9	-1.0	-1.9	-0.7
Medication: Cholesterol lowering	0.6	0.9	3.8	-1.9	-0.3	-0.7	-0.9	-0.3	-0.7	0.6
Prospective memory result	0.6	0.7	1.8	-0.2	-0.4	0.1	-1.0	-0.4	1.3	-1.3
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.6	-0.6	-0.8	-1.3	-0.7	0.7	-1.2	-0.3
Medication: Amlodipine	0.6	0.8	2.8	-1.7	0.6	-0.2	0.6	-0.8	-0.2	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	2.4	0.3	1.0	0.2	0.8	-0.4	-1.6	-0.6
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.0	-1.4	0.3	1.1	0.2	1.1	0.6	0.4
Breast cancer (self-reported)	0.6	0.7	1.4	-1.2	-0.8	-1.0	-0.2	0.4	-0.6	1.1
Medication: Atorvastatin	0.6	0.7	2.4	-1.6	-0.5	-0.3	0.8	-0.3	-0.8	0.9
Rheumatoid Arthritis	0.5	0.8	3.1	-0.1	1.1	0.8	-0.1	0.5	-1.8	-0.3
Schizophrenia (2014)	0.5	1.0	3.0	-0.3	-1.1	-0.4	1.2	-1.7	0.7	0.8
Systolic Blood Pressure	0.5	2.4	8.6	-2.3	0.5	-0.6	-0.3	-1.4	-2.9	-0.6
Other serious medical condition/disability diagnosed by doctor	0.5	0.7	2.5	-0.8	0.9	-0.1	-0.6	0.2	-1.6	0.7
Medication: Metformin	0.5	0.7	2.8	0.1	-0.6	-0.8	0.5	-0.7	-0.3	1.7
Severe depression (siblings)	0.5	0.5	1.7	-1.3	-0.2	-0.6	-0.8	-0.1	0.8	0.6
Average weekly fortified wine intake	0.5	0.6	2.6	0.5	0.3	-0.1	1.0	0.6	-0.5	-1.6
Age when periods started (menarche)	0.5	1.3	3.0	0.8	1.1	1.7	0.8	1.5	1.1	-0.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.4	-0.2	-0.8	-1.2	-0.7	-1.1	0.5	0.3
Medication: Ramipril	0.5	0.7	2.0	0.0	1.4	0.8	-0.5	0.1	-1.3	0.5
Fluid intelligence score	0.5	1.1	3.6	1.9	1.0	0.5	1.0	-0.2	0.2	1.3
Father’s age at death	0.5	0.7	2.1	0.3	-0.6	-0.9	0.0	-0.5	-1.2	-1.4
Asthma	0.5	0.9	4.2	-1.2	-0.3	0.1	-2.0	0.6	0.6	-0.4
Lung cancer (father)	0.5	0.6	2.4	-1.6	-0.1	-0.6	-0.8	0.5	0.7	-0.2
Gout (self-reported)	0.5	0.6	1.9	-0.8	0.6	0.1	0.8	0.4	0.9	1.4
Worry too long after embarrassment	0.5	0.9	1.8	-0.3	-1.2	-1.2	-1.2	0.2	1.3	0.3
Eye problems/disorders: None of the above	0.5	0.6	2.0	-0.9	0.4	0.1	-1.4	0.4	-0.8	-0.7
Medication for pain relief, constipation, heartburn	0.5	0.8	1.8	-1.1	-1.1	-1.0	-0.6	-0.0	-0.1	-1.3
Illnesses of father: Heart disease	0.5	0.7	2.9	-0.2	-0.2	-0.1	-1.3	1.7	0.5	-0.1
Ever taken oral contraceptive pill	0.5	0.6	2.1	0.0	0.3	-0.2	-1.5	-0.8	-0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.5	0.6	2.3	0.1	0.5	0.1	0.4	-1.2	-0.5	-1.5
Medication: Paracetamol	0.5	0.8	2.5	0.5	-0.8	-0.7	-1.6	-0.5	1.1	0.7
Medication: Lisinopril	0.5	0.6	0.9	-0.9	0.9	0.9	0.8	0.5	0.5	0.9
Diastolic blood pressure, automated reading	0.5	1.5	4.7	0.3	1.9	2.2	-1.0	0.6	0.1	0.7
Vascular/heart problems diagnosed by doctor	0.5	1.5	3.2	1.2	-1.8	-1.5	0.6	0.1	1.4	-1.1
Cholesterol lowering medication	0.5	0.8	2.4	-0.8	0.6	0.7	-0.8	0.9	-0.4	1.6
Heart disease (siblings)	0.5	0.6	3.2	0.1	-0.4	0.6	0.5	-0.1	1.8	-0.5
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.7	0.3	0.4	-1.1	-0.8	-1.0	0.2
Blood Eosinophil Count	0.4	2.9	13.4	-3.7	-1.4	-0.6	1.2	-0.7	-0.4	-1.6
Allergy or Eczema	0.4	0.9	2.2	0.7	-0.2	-0.7	-0.7	-1.5	-1.4	-0.9
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.1	-0.7	-0.5	-0.5	1.1	-0.3	-0.6	0.3
Trunk fat percentage	0.4	1.6	3.6	-0.9	-1.4	-1.9	1.3	-0.9	1.4	-0.9
Hand grip strength (right)	0.4	1.2	2.1	1.5	-0.7	0.1	-1.4	1.2	1.3	0.6
Relative age voice broke	0.4	0.6	1.5	1.2	-0.7	-0.3	-0.2	0.9	0.8	-0.8
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.6	0.1	1.0	1.3	-0.7	0.4	-0.2	0.6
High blood pressure	0.4	1.2	3.6	-0.4	1.9	1.3	-0.2	-0.1	-1.3	1.0
Medication: Levothyroxine sodium	0.4	0.7	1.5	-0.4	-0.8	0.2	-1.1	1.2	1.0	0.5
Had menopause	0.4	0.6	2.8	-0.5	-0.1	0.5	0.6	0.5	-0.2	1.7
Tense / ‘highly strung’	0.4	0.7	2.3	0.4	-0.5	-0.3	-1.5	1.2	0.5	0.3
Medication: Paracetamol	0.4	0.7	1.9	1.4	0.1	-0.0	-0.6	-1.3	0.8	0.7
Birth weight	0.4	0.8	1.9	0.7	1.4	1.2	-1.1	-0.1	-0.7	0.4
Body fat percentage	0.4	1.5	2.8	-1.2	-1.4	-1.7	1.3	-0.7	1.3	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.0	-0.5	-0.7	-1.0	-0.1	-0.9	0.1	-0.8
Qualifications: College or University degree	0.4	1.3	3.2	-0.3	1.6	1.4	1.1	-0.1	-1.8	-0.5
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.4	-0.1	0.4	-1.1	-1.2	0.2	-0.3
Supplements: Vitamin C	0.4	0.5	2.7	0.6	0.0	0.5	1.6	-0.0	-0.1	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.9	-1.0	-0.9	-0.7	0.5	0.3	-0.2	0.3
Medication: Aspirin	0.4	0.5	1.2	-0.8	0.4	0.5	0.4	1.0	0.5	1.1
Illnesses of father: None of the above (group 1)	0.4	0.5	0.7	0.7	-0.8	-0.6	-0.4	0.4	0.8	0.9
Commuting to job workplace: Public transport	0.4	0.5	3.1	-0.0	0.6	0.0	-0.5	0.2	-0.0	1.8
Alcohol drinker status: Never	0.4	0.5	1.5	0.1	0.5	0.8	0.7	0.6	0.4	-1.2
Irritability	0.4	0.7	2.6	0.4	-0.9	-0.8	-0.5	-0.1	1.6	0.2
Risk taking	0.4	0.6	2.0	-1.4	0.3	-0.1	1.0	-0.6	-0.7	0.4
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	0.3	0.3	0.7	0.7	-1.2	-0.5	-0.2
Bipolar Disorder or Schizophrenia	0.3	0.6	1.9	0.0	-1.2	-0.8	-0.5	-1.4	-0.0	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	0.6	0.4	0.4	-0.2	-1.1	-0.0	-1.0
Breast Cancer	0.3	0.8	3.0	-0.2	1.1	0.2	1.1	0.6	-1.7	0.0
Bipolar Disorder (2011)	0.3	0.3	1.7	0.2	-0.0	0.3	-1.3	-0.7	0.4	0.0
HDL Cholesterol	0.3	0.5	1.3	-0.2	1.0	0.6	1.1	-0.1	-0.3	-0.6
LDL Cholesterol	0.3	0.5	1.5	1.2	0.7	0.7	0.3	-0.1	0.4	0.6
Ulcerative Colitis	0.3	0.5	2.0	0.5	0.0	1.4	0.5	0.7	-0.3	-0.5
Blood Platelet Count	0.3	3.8	9.1	-0.3	2.7	3.0	2.5	-1.2	-1.5	-0.2
Maternal smoking around birth	0.3	0.4	1.2	0.4	-0.1	-0.4	-0.1	0.6	0.9	1.1
Noisy workplace	0.3	0.4	0.9	0.1	-1.0	-0.9	0.3	-0.9	0.2	0.3
Hair/balding pattern: Pattern 4	0.3	0.8	2.8	0.4	0.3	0.4	-1.0	1.0	1.7	-0.7
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.0	-0.1	-0.5	0.1	-0.9	0.6	0.5	1.0
Number of children fathered	0.3	0.3	0.9	0.4	-0.2	0.1	0.4	0.4	0.9	-0.8
Leg fat mass (right)	0.3	1.2	5.9	-0.3	-0.8	-0.3	0.4	1.2	2.4	0.2
Medication: Aspirin	0.3	0.4	0.8	-0.7	0.6	0.6	0.5	0.9	0.0	0.8
Hypertension (Self-reported)	0.3	0.9	3.0	-0.0	1.7	1.1	-0.2	-0.0	-1.3	0.7
Average weekly red wine intake	0.3	0.4	1.5	-0.6	-0.6	-0.5	-0.0	0.3	-0.6	-1.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	2.2	-0.2	-0.3	-0.2	0.2	-0.5	-1.5	-0.4
Osteoarthritis (self-reported)	0.3	0.4	0.8	-0.3	0.8	0.8	0.6	0.4	0.5	0.9
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	-1.2	0.6	0.3	0.1	0.5	0.3	1.1
Guilty feelings	0.3	0.4	1.9	-0.4	-0.3	-0.2	-0.5	-0.7	-1.4	-0.3
Mother’s age at death	0.3	0.4	1.0	1.0	-0.5	-0.4	0.8	0.5	-0.4	-0.6
Number of operations (self-reported)	0.3	0.5	0.9	0.7	-0.9	-0.6	0.3	-0.8	0.7	0.9
Leg fat mass (left)	0.3	1.4	6.5	-0.3	-0.8	-0.4	0.2	1.4	2.5	0.5
Crohns Disease (2017)	0.2	0.5	1.2	-0.9	0.4	0.3	1.1	-1.0	0.0	0.4
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	-0.5	-0.0	0.7	1.5	-0.3	0.1	-0.8
Ulcerative Colitis (UC)	0.2	0.4	0.9	-0.0	-0.7	0.5	1.0	0.4	0.1	-0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	1.6	1.3	0.3	-0.4	0.9	0.0	-0.4	-0.2
Number of treatments/medications taken	0.2	0.3	0.8	-0.4	0.9	0.4	-0.6	0.0	0.0	0.8
Medication: Atenolol	0.2	0.3	0.7	-0.4	0.3	0.3	-0.6	0.8	0.4	0.7
Body mass index (BMI)	0.2	0.7	2.9	-1.7	0.0	0.1	-1.0	0.7	0.5	0.4
Trunk fat mass	0.2	1.0	5.8	0.5	-0.6	-0.6	0.4	0.5	2.4	-0.2
Alcohol usually taken with meals	0.2	0.4	0.7	0.8	-0.8	-0.4	0.7	-0.2	0.5	0.5
Arm fat percentage (right)	0.2	0.7	2.8	-1.7	-0.2	-0.7	0.7	-1.0	0.3	-0.3
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.0	0.5	-0.3	0.3	0.8	0.3	0.0	-1.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.9	0.2	-0.6	-0.4	-1.0	0.4	0.7	-0.5
Age at first live birth	0.2	0.3	0.9	0.3	-0.5	0.4	0.9	-0.0	0.9	-0.0
Mouth/teeth dental problems: Loose teeth	0.2	0.2	1.3	-0.1	0.3	0.2	0.1	0.3	0.4	1.1
Medication: Blood pressure	0.2	0.3	0.9	-0.1	0.9	0.2	-0.4	-0.7	-0.3	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.3	0.8	0.1	-0.8	-0.5	0.3	0.2	-0.4	0.9
Whole body fat mass	0.2	0.9	4.9	0.3	-0.6	-0.5	0.3	0.7	2.2	0.3
Age at last live birth	0.2	0.4	1.3	1.1	0.3	0.9	0.5	0.1	0.0	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	1.0	0.1	-1.0	0.3	0.2	0.3	0.2	-0.1
Arm fat percentage (left)	0.2	0.8	3.0	-1.7	-0.3	-0.8	0.7	-0.9	0.1	-0.6
Diabetes diagnosed by doctor	0.2	0.3	0.7	0.5	-0.6	-0.5	-0.0	-0.8	-0.7	0.4
Qualifications: nursing, teaching	0.2	0.3	0.6	-0.1	0.8	0.6	-0.6	0.8	-0.1	0.3
Average weekly champagne plus white wine intake	0.2	0.2	0.6	-0.5	-0.7	-0.8	0.4	-0.0	0.2	0.5
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.0	0.3	0.9	0.0	0.4	0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	0.4	0.3	0.0	-0.7	0.8	-0.6	0.1
Schizophrenia (2018)	0.1	0.3	1.0	0.3	-0.7	-0.1	0.4	-1.0	0.5	0.4
Blood Red Count	0.1	1.2	2.3	0.4	1.5	1.5	1.5	0.9	0.8	-0.0
BMI	0.1	0.8	3.1	-1.8	0.2	0.5	-1.1	0.5	0.4	0.7
Cardiovascular Disease	0.1	0.4	1.5	-0.9	0.4	0.2	-0.2	0.3	-0.3	1.2
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	0.2	-0.3	-0.4	0.4	-0.6	-0.7	-0.2
Tanning	0.1	0.7	2.1	1.1	-0.5	-1.0	-0.3	-0.4	-1.4	0.1
Ever had hysterectomy (womb removed)	0.1	0.2	0.4	-0.2	-0.1	-0.5	0.5	0.2	-0.3	0.6
Waist circumference	0.1	0.5	2.2	-0.1	-0.2	-0.0	-0.3	1.2	1.5	0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.5	-0.2	0.3	0.1	0.6	-0.7	-0.2	-0.2
Arm fat mass (right)	0.1	0.4	1.9	-0.2	0.1	0.1	-0.4	0.6	1.4	0.3
Alcohol intake frequency.	0.1	0.2	0.4	-0.2	0.6	0.4	0.2	0.2	0.6	0.6
Arm fat mass (left)	0.1	0.4	2.1	-0.2	-0.1	0.0	-0.4	0.7	1.5	0.1
Hair Pigment	0.0	1.1	3.4	-0.5	0.4	0.5	-1.7	0.4	1.8	0.3

Hub : Genes

TMEM43

Models

Trait associations