TWAS hub - WNT7A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.072	0.0330	0.01600	0.006	0.023	0.020	0.030	0.017	6e-02	6.8e-04	1.5e-03	1.3e-04	3.1e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.124	0.0377	0.00029	0.039	0.037	0.049	0.041	0.043	9e-06	1.2e-05	6.6e-07	4.9e-06	3.0e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Eye problems/disorders: Glaucoma	8.7	10.3	12.5	-3.5	-2.8
Pain type(s) experienced in last month: Hip pain	6.4	8.0	12.5	-1.9	-3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	5.8	6.8	7.8	2.4	2.8
Hayfever/allergic rhinitis (self-reported)	5.3	7.0	9.1	2.2	3.0
Diabetes (father)	4.8	6.0	10.2	3.2	1.3
Had major operations	4.8	5.7	8.1	-2.8	-1.8
Arm predicted mass (right)	4.7	24.2	26.8	-4.7	-5.2
Arm predicted mass (left)	4.5	23.0	24.6	-4.6	-5.0
Past tobacco smoking	4.4	8.1	10.1	3.2	2.5
Arm fat-free mass (right)	4.4	22.8	25.6	-4.5	-5.1
Arm fat-free mass (left)	4.4	22.5	24.1	-4.6	-4.9
Tinnitus: Yes, but not now, but have in the past	4.3	4.5	6.8	-2.6	-1.5
Glaucoma (self-reported)	4.3	5.1	5.9	-2.1	-2.4
Reaction Time	3.7	7.1	9.2	3.0	2.2
Prospective memory result	3.7	4.6	9.0	0.4	3.0
Trunk fat-free mass	3.5	20.0	22.8	-4.1	-4.8
Lung cancer (father)	3.5	4.1	5.6	2.4	1.6
Standing height	3.5	35.0	35.4	-5.9	-6.0
Trunk predicted mass	3.4	19.4	22.0	-4.1	-4.7
Medication: Seretide 50 evohaler	3.4	3.9	4.2	-2.0	-1.9
Sitting height	3.3	23.2	26.9	-5.2	-4.4
Diabetes (self-reported)	3.2	5.0	7.0	-2.7	-1.7
Heart disease (mother)	3.2	3.9	4.2	-2.1	-1.9
Whole body water mass	3.2	18.0	19.6	-4.0	-4.4
Basal metabolic rate	3.2	17.7	18.1	-4.2	-4.3
Whole body fat-free mass	3.1	17.5	19.0	-4.0	-4.4
Alcohol drinker status: Never	3.1	3.7	5.2	1.5	2.3
Medication: Omeprazole	3.0	3.6	5.7	2.4	1.2
Exposure to tobacco smoke at home	2.9	3.2	4.2	-2.0	-1.5
Hand grip strength (left)	2.8	7.3	8.1	-2.8	-2.5
Forced expiratory volume in 1-second (FEV1)	2.8	9.5	14.5	-2.1	-3.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.8	8.9	14.0	-2.0	-3.7
Ever smoked	2.8	4.8	6.6	-2.6	-1.8
Smoking Status	2.7	6.5	9.6	-3.1	-1.8
Loud music exposure frequency	2.7	3.0	5.2	-0.8	-2.3
Mouth/teeth dental problems: Bleeding gums	2.6	3.4	4.2	-2.0	-1.6
Weight	2.5	12.5	13.8	-3.7	-3.3
Height	2.4	46.7	48.7	-6.7	-7.0
Comparative height size at age 10	2.4	13.0	15.9	-3.2	-4.0
Smoking status: Previous	2.3	3.4	3.8	-1.9	-1.7
Heart attack	2.2	2.8	4.3	1.2	2.1
Peak expiratory flow (PEF)	2.2	5.1	7.7	-1.6	-2.8
Chest pain or discomfort	2.2	3.1	3.6	1.9	1.6
Commuting to job workplace: Car/motor vehicle	2.2	2.5	3.0	-1.4	-1.7
Ever had bowel cancer screening	2.2	2.6	4.6	0.7	2.1
Miserableness	2.2	3.8	4.6	-2.1	-1.7
Alzheimer’s Disease (in mother)	2.1	2.5	3.2	-1.8	-1.3
Leg fat mass (right)	2.1	8.2	10.8	-3.3	-2.4
Knee pain experienced in last month	2.1	3.2	5.3	-1.1	-2.3
Leg fat mass (left)	2.1	8.0	11.0	-3.3	-2.2
Hand grip strength (right)	2.0	5.5	6.8	-2.1	-2.6
Forced vital capacity (FVC)	2.0	7.6	10.9	-2.1	-3.3
Mean time to correctly identify matches	2.0	3.8	3.9	2.0	1.9
Leg fat-free mass (right)	2.0	10.7	11.4	-3.4	-3.2
Leg predicted mass (right)	2.0	10.7	11.4	-3.4	-3.2
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	3.3	1.8	1.2
Leg fat-free mass (left)	1.9	10.2	11.0	-3.3	-3.1
Hayfever, allergic rhinitis or eczema	1.9	4.1	5.6	1.6	2.4
Leg predicted mass (left)	1.9	10.2	11.0	-3.3	-3.1
Ever highly irritable/argumentative for 2 days	1.9	2.3	2.4	-1.5	-1.5
Loneliness, isolation	1.9	2.7	3.3	-1.4	-1.8
Hearing aid user	1.9	2.2	2.5	1.4	1.6
Bipolar Disorder (2011)	1.8	1.7	2.2	-1.5	-1.1
Frequency of depressed mood in last 2 weeks	1.8	2.6	4.0	-2.0	-1.1
Trunk fat mass	1.8	7.7	11.0	-3.3	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.8	3.8	6.6	-1.0	-2.6
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	2.2	1.5	1.4
Forced vital capacity (FVC), Best measure	1.7	6.0	9.0	-1.8	-3.0
Angina (self-reported)	1.7	2.2	4.3	-2.1	-0.2
Whole body fat mass	1.7	6.9	9.7	-3.1	-2.0
Average weekly red wine intake	1.7	2.5	3.2	-1.8	-1.4
Ever used hormone-replacement therapy (HRT)	1.6	2.1	3.6	1.9	0.8
Shortness of breath walking on level ground	1.6	1.9	2.5	-1.2	-1.6
Heart attack/myocardial infarction (self-reported)	1.6	2.1	3.4	0.9	1.8
Crohns Disease (2012)	1.5	2.4	4.2	-0.8	-2.1
Angina	1.5	1.9	3.8	-1.9	-0.3
Time employed in main current job	1.5	1.8	3.4	-0.4	-1.9
Father’s age at death	1.5	2.0	3.2	-0.9	-1.8
High blood pressure (siblings)	1.5	2.1	3.3	1.0	1.8
Alzheimer’s Disease (in father)	1.4	1.5	2.8	1.7	0.4
Ulcerative Colitis	1.4	2.1	3.3	1.8	0.9
Medication: Co-codamol	1.4	1.6	2.9	-0.5	-1.7
Average weekly fortified wine intake	1.4	1.6	3.0	-0.5	-1.7
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	3.7	-1.9	-0.8
Hip circumference	1.4	5.9	6.4	-2.5	-2.3
Diabetes diagnosed by doctor	1.4	2.4	3.0	-1.7	-1.3
Depression (Nagel 2018)	1.3	1.9	2.4	-1.5	-1.2
Lung FEV1/FVC ratio	1.3	6.4	8.2	-2.1	-2.9
Medication: Levothyroxine sodium	1.3	2.1	3.5	0.9	1.9
Noisy workplace	1.3	1.6	3.0	-0.4	-1.7
Health satisfaction	1.3	1.7	3.3	1.8	-0.4
Osteoarthritis (self-reported)	1.3	1.7	3.3	-0.2	-1.8
Ever taken oral contraceptive pill	1.3	1.5	1.9	-1.0	-1.4
Medication for hormone replacement therapy	1.2	1.3	1.7	1.3	1.0
Fed-up feelings	1.2	2.2	3.5	-1.9	-1.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	2.3	1.5	0.7
Number of children fathered	1.2	1.4	1.9	-1.4	-1.0
Pulse wave peak to peak time	1.2	1.4	1.5	-1.2	-1.2
Mood swings	1.2	2.2	3.2	-1.8	-1.1
Ever depressed for a whole week	1.2	1.5	2.9	-0.3	-1.7
Depressed Affect (Nagel 2018)	1.1	2.2	2.6	-1.6	-1.4
Coronary Artery Disease (CAD)	1.1	1.3	1.7	1.3	1.0
Systolic Blood Pressure	1.1	5.4	8.2	1.6	2.9
Ever had hysterectomy (womb removed)	1.1	1.3	1.6	1.3	1.0
Pack years adult smoking proportion	1.1	1.6	2.5	1.6	0.9
Comparative body size at age 10	1.1	3.0	4.9	1.1	2.2
Medication for cholesterol	1.1	1.6	2.9	-1.7	-0.6
Pack years of smoking	1.1	1.7	2.4	1.6	1.0
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	1.3	-1.1	-1.1
Medication: Metformin	1.0	1.4	1.6	-1.1	-1.3
Taking other prescription medications	1.0	1.5	2.6	1.6	0.6
Arm fat mass (left)	1.0	4.1	6.0	-2.5	-1.5
Guilty feelings	1.0	1.5	1.7	1.3	1.1
Wears glasses or contact lenses	1.0	1.2	2.0	0.5	1.4
Vascular/heart problems diagnosed by doctor	1.0	2.6	2.8	-1.5	-1.7
Heart disease (siblings)	1.0	1.2	2.1	0.6	1.4
Prostate Cancer	0.9	1.2	2.1	1.4	0.6
Birth weight of first child	0.9	1.7	3.4	0.0	-1.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.9	-1.4	-0.3
Back pain experienced in last month	0.9	1.3	1.4	-1.2	-1.1
Body Mass Index (BMI) (2010)	0.8	1.1	2.3	-0.1	-1.5
Neuroticism (2016)	0.8	1.2	1.3	-1.0	-1.1
Trunk fat percentage	0.8	3.0	5.3	-2.3	-0.9
Supplements: Glucosamine	0.8	1.1	1.5	1.2	-0.8
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.8	0.3	-1.3
Illnesses of siblings	0.8	1.1	1.7	-0.7	-1.3
Falls in the last year	0.8	1.0	1.6	1.3	0.7
Happiness	0.8	1.0	1.8	0.5	-1.3
Impedance of arm (left)	0.8	3.7	5.3	1.4	2.3
Arm fat mass (right)	0.8	3.1	4.5	-2.1	-1.3
Length of working week for main job	0.8	0.9	1.7	1.3	0.2
Hair/balding pattern: Pattern 4	0.8	2.0	2.3	-1.3	-1.5
Pulse wave reflection index	0.8	1.0	1.2	0.9	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	1.6	-0.6	-1.2
Commuting to job workplace: Walk	0.8	0.9	1.7	-0.1	1.3
Medication: Gliclazide	0.8	0.9	1.4	-0.5	-1.2
Medication: Blood pressure	0.8	1.5	2.1	1.4	1.0
Leg fat percentage (left)	0.8	2.9	4.8	-2.2	-1.0
Fractured/broken bones in last 5 years	0.8	1.1	2.0	-1.4	-0.4
Supplements: Calcium	0.8	0.9	1.1	1.1	0.9
Neuroticism (Nagel 2018)	0.7	1.8	2.4	-1.6	-1.1
Systolic blood pressure, automated reading	0.7	2.0	3.7	0.6	1.9
Waist circumference	0.7	2.5	3.3	-1.8	-1.3
Mouth/teeth dental problems	0.7	1.1	2.0	0.5	1.4
Pain all over the body in last month	0.7	0.8	1.1	1.1	0.7
Impedance of arm (right)	0.7	3.2	4.5	1.4	2.1
Body fat percentage	0.7	2.7	4.6	-2.1	-0.9
Mineral and other dietary supplements	0.7	1.0	1.7	-1.3	0.6
Number of operations (self-reported)	0.7	1.0	1.4	-0.8	-1.2
Waist Hip Ratio (WHR)	0.6	2.7	2.8	1.6	1.7
Cardiovascular Disease	0.6	2.1	3.6	1.9	0.8
Hypothyroidism (self reported)	0.6	1.4	2.9	-0.2	1.7
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.6	-1.3	-0.8
Medication: Atenolol	0.6	0.8	0.9	-0.8	-1.0
Number of incorrect matches in round	0.6	0.9	1.3	1.1	0.8
Allergy	0.6	1.5	2.2	-0.8	-1.5
Medication: Simvastatin	0.6	0.9	0.9	0.9	1.0
Number of live births	0.6	0.8	1.6	-1.2	-0.1
Blood clot in the leg (DVT)	0.6	0.7	1.0	-0.7	1.0
Medication: Paracetamol	0.6	1.1	1.9	-0.5	-1.4
Medication: Amlodipine	0.6	0.8	1.2	-1.1	-0.7
Leg fat percentage (right)	0.6	2.3	3.8	-1.9	-0.9
Wheeze or whistling in the chest in last year	0.6	1.1	2.0	-0.5	-1.4
Leg pain on walking	0.6	0.7	0.8	-0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	1.9	-1.4	-0.8
Bipolar Disorder (2018)	0.5	0.9	1.7	-1.3	-0.1
Worry (Nagel 2018)	0.5	1.1	1.3	-0.9	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	0.8	-0.9	-0.8
Chronic bronchitis/emphysema (father)	0.5	0.6	1.1	-0.2	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	1.8	0.2	1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.3	1.0
Supplements: Vitamin C	0.5	0.6	1.0	0.4	1.0
Smoking status: Current	0.5	0.8	1.5	-1.2	-0.2
Medication: Bendroflumethiazide	0.5	0.8	1.6	1.2	0.3
Illnesses of father: High blood pressure	0.5	0.7	1.1	-0.5	-1.0
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.0	0.2	1.0
Myopia	0.5	0.7	1.1	-0.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.1	-0.5	1.1
Alcohol drinker status: Previous	0.5	0.5	1.0	1.0	-0.3
Ulcerative Colitis (UC)	0.4	0.7	1.4	1.2	0.1
Mean Putamen Volume	0.4	0.5	0.6	-0.8	-0.6
HDL Cholesterol	0.4	0.6	0.9	0.6	0.9
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.0	-1.0	-0.0
Allergy or Eczema	0.4	1.1	1.3	0.9	1.2
Neuroticism	0.4	1.0	1.1	-0.9	-1.1
Chronotype (morning person)	0.4	1.0	1.3	-1.1	-0.8
Relative age of first facial hair	0.4	0.8	1.1	-0.7	-1.0
Severe depression (siblings)	0.4	0.5	1.0	0.2	1.0
Financial difficulties in last 2 years	0.4	0.5	0.6	-0.7	-0.8
Hair/balding pattern: Pattern 3	0.4	0.7	1.1	-1.0	-0.5
Medication: Cholesterol lowering	0.4	0.6	1.1	0.4	1.0
Illnesses of mother	0.4	0.5	0.8	0.9	0.3
Pulse wave Arterial Stiffness index	0.4	0.5	0.5	0.7	0.7
Breastfed as a baby	0.4	0.5	1.0	1.0	-0.1
Medication for pain relief, constipation, heartburn	0.4	0.7	1.2	-0.3	1.1
Medication: Allopurinol	0.4	0.5	0.9	-0.9	-0.5
Number of full sisters	0.4	0.5	0.9	1.0	-0.1
Family relationship satisfaction	0.4	0.4	0.8	0.2	0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	0.9	0.4	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	0.9	0.3
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.2	0.2	1.1
Breast cancer (self-reported)	0.4	0.4	0.8	0.2	-0.9
Tinnitus: Yes, now most or all of the time	0.4	0.4	0.7	-0.8	-0.5
Crohns Disease (2017)	0.3	0.6	1.1	0.3	-1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.3	1.1	-0.4
Ovarian Cancer	0.3	0.4	0.6	0.4	0.8
Fasting Glucose	0.3	0.4	0.6	0.4	-0.8
Respiratory disease	0.3	0.7	1.3	-0.4	-1.1
Average weekly spirits intake	0.3	0.4	0.4	-0.6	-0.7
Supplements: Zinc	0.3	0.3	0.6	0.8	0.1
Diabetes (mother)	0.3	0.3	0.5	-0.7	-0.5
Current tobacco smoking	0.3	0.6	1.1	-1.1	-0.2
Multivitamins +/- minerals	0.3	0.3	0.6	0.8	0.2
Body mass index (BMI)	0.3	1.1	1.6	-1.3	-0.7
Medication: Ramipril	0.3	0.4	0.7	-0.8	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.5	-0.7	-0.5
Pulse rate	0.3	0.5	0.8	-0.4	-0.9
Mouth/teeth dental problems: Dentures	0.3	0.5	0.8	0.5	-0.9
Depression (self-reported)	0.3	0.3	0.6	-0.1	-0.8
Tense / ‘highly strung’	0.3	0.5	0.6	-0.6	-0.7
Headache pain in last month	0.3	0.5	1.0	0.1	1.0
Eye problems/disorders: None of the above	0.3	0.3	0.4	0.6	-0.6
Medication: Ibuprofen	0.3	0.4	0.6	-0.4	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.3	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	0.5	0.7
Financial situation satisfaction	0.3	0.4	0.5	0.7	-0.6
Risk taking	0.3	0.5	0.8	0.9	0.5
Schizophrenia vs Biploar Disorder	0.2	0.2	0.4	0.6	-0.1
Alzheimer’s Disease (including proxy)	0.2	0.2	0.3	-0.4	-0.6
Age at First Birth	0.2	0.2	0.4	-0.3	-0.6
HbA1C	0.2	0.2	0.4	0.0	-0.6
Schizophrenia (2014)	0.2	0.4	0.5	0.5	0.7
Triglycerides	0.2	0.3	0.5	-0.3	-0.7
Blood Platelet Count	0.2	2.2	4.0	2.0	0.7
Number of treatments/medications taken	0.2	0.3	0.5	0.7	-0.4
Sensitivity / hurt feelings	0.2	0.3	0.4	-0.4	0.7
Hearing difficulty/problems: Yes	0.2	0.3	0.5	-0.7	-0.2
Maternal smoking around birth	0.2	0.3	0.3	-0.5	0.6
High blood pressure	0.2	0.7	0.7	0.8	0.8
High blood pressure (mother)	0.2	0.2	0.4	-0.7	-0.2
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	0.5	0.3
Neuroticism score	0.2	0.3	0.6	-0.7	-0.3
Alcohol intake versus 10 years previously	0.2	0.3	0.4	0.7	-0.4
Birth weight	0.2	0.5	0.7	-0.6	-0.8
Number of full brothers	0.2	0.2	0.4	0.6	0.2
Emphysema/chronic bronchitis	0.2	0.2	0.2	0.5	0.4
Medication: Blood pressure	0.2	0.3	0.6	-0.8	0.1
Alcohol intake frequency.	0.2	0.4	0.5	0.7	0.5
Long-standing illness, disability or infirmity	0.2	0.3	0.6	-0.8	-0.1
Osteoporosis (self-reported)	0.2	0.2	0.4	-0.1	0.6
Illnesses of father: None of the above (group 1)	0.2	0.2	0.4	-0.2	-0.6
Mother’s age at death	0.2	0.2	0.5	0.0	-0.7
High cholesterol (Self-reported)	0.2	0.4	0.6	0.4	-0.8
Cholesterol lowering medication	0.2	0.3	0.4	0.5	-0.6
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.3	-0.6
Bipolar Disorder or Schizophrenia	0.1	0.1	0.2	-0.5	0.2
Intelligence (Savage-Jansen 2018)	0.1	0.3	0.7	-0.1	0.8
Schizophrenia (2018)	0.1	0.1	0.2	0.4	0.3
Major Depression (MDD)	0.1	0.2	0.3	-0.6	-0.1
Breast Cancer	0.1	0.2	0.4	-0.2	-0.6
Lupus	0.1	0.2	0.4	0.1	-0.6
Primary Biliary Cirrhosis	0.1	0.1	0.1	0.4	0.3
Blood Eosinophil Count	0.1	0.4	0.8	-0.9	0.1
Blood White Count	0.1	1.0	1.6	1.3	0.6
Heel T-Score	0.1	0.4	0.6	0.8	0.5
Lung FVC	0.1	0.3	0.4	0.3	-0.6
Hair Pigment	0.1	2.7	3.2	-1.4	-1.8
Tanning	0.1	1.6	2.2	-1.0	-1.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.1	0.4
Relative age voice broke	0.1	0.1	0.2	0.4	0.1
Age when periods started (menarche)	0.1	0.3	0.6	-0.2	-0.8
Qualifications: CSEs or equivalent	0.1	0.1	0.1	0.1	0.4
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.3	-0.3
Impedance of leg (left)	0.1	0.5	0.5	-0.7	-0.6
Alcohol usually taken with meals	0.1	0.1	0.2	0.4	0.0
Nervous feelings	0.1	0.3	0.4	-0.6	-0.4
Had menopause	0.1	0.1	0.1	-0.1	-0.3
Arm fat percentage (right)	0.1	0.5	1.0	-1.0	0.2
Worrier / anxious feelings	0.1	0.1	0.1	-0.3	0.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.3	0.1	-0.5
Medication: Lansoprazole	0.1	0.1	0.1	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.4	0.2	0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	0.3	-0.4
Gout (self-reported)	0.1	0.2	0.2	0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	-0.3
Exposure to tobacco smoke outside home	0.1	0.1	0.1	0.2	0.4
Worry too long after embarrassment	0.1	0.2	0.3	0.0	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.3	0.5	0.1
Age at first live birth	0.1	0.2	0.3	0.2	-0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	0.4	0.3
Neck or shoulder pain in last month	0.1	0.2	0.2	-0.5	-0.4
Migraine (self-reported)	0.1	0.1	0.2	-0.4	0.2
Suffer from ‘nerves’	0.1	0.2	0.3	0.1	0.6
Overall health rating	0.1	0.3	0.5	0.7	0.4
Age at last live birth	0.1	0.1	0.3	0.5	0.1
Hypertension (Self-reported)	0.1	0.3	0.4	0.7	0.4
Illnesses of father: Heart disease	0.1	0.2	0.3	-0.5	-0.2
Arm fat percentage (left)	0.1	0.5	1.0	-1.0	0.3
Friendships satisfaction	0.1	0.1	0.2	0.5	-0.1
Qualifications: nursing, teaching	0.1	0.2	0.2	0.5	0.4
Eye problems/disorders: Cataract	0.1	0.2	0.2	-0.4	0.4
Number of self-reported non-cancer illnesses	0.1	0.1	0.2	-0.4	0.1
Commuting to job workplace: Public transport	0.1	0.1	0.1	0.3	-0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.1	-0.6
Medication: Paracetamol	0.1	0.1	0.2	-0.3	-0.4
Medication: Lisinopril	0.1	0.1	0.3	-0.5	0.1
Medication: Atorvastatin	0.1	0.2	0.3	0.1	-0.5
Average weekly beer plus cider intake	0.1	0.1	0.1	-0.3	0.3
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	-0.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	-0.4	0.2
Pain experienced in last month	0.1	0.2	0.3	-0.6	-0.2
Impedance of whole body	0.1	0.4	0.8	0.1	0.9
Verbal and Numeric Reasoning (VNR)	0.0	0.1	0.1	-0.3	0.3
LDL Cholesterol	0.0	0.0	0.0	-0.1	0.1
Rheumatoid Arthritis	0.0	0.0	0.0	-0.1	0.1
Blood Red Count	0.0	0.1	0.1	0.1	0.3
BMI	0.0	0.1	0.1	0.3	0.4
Vitamin and mineral supplements	0.0	0.0	0.0	-0.2	0.0
Impedance of leg (right)	0.0	0.2	0.2	-0.3	-0.5
Townsend deprivation index at recruitment	0.0	0.1	0.1	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.0	0.0	0.1	-0.3	0.2
Stomach or abdominal pain in last month	0.0	0.0	0.1	0.2	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	0.2
Had other major operations	0.0	0.0	0.0	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.0	0.0	0.1	-0.2	-0.1
Qualifications: None of the above	0.0	0.0	0.0	-0.2	0.1
Fluid intelligence score	0.0	0.0	0.1	0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.1	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.1	0.1
Asthma	0.0	0.0	0.0	0.2	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.3	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	-0.2	-0.1
Qualifications: College or University degree	0.0	0.0	0.0	-0.1	0.0
Pulse rate, automated reading	0.0	0.1	0.2	0.2	-0.5
Illness, injury, bereavement, stress in last 2 years	0.0	0.0	0.0	0.1	-0.2
Medication: Aspirin	0.0	0.1	0.1	0.1	-0.3
Asthma (self-reported)	0.0	0.0	0.1	0.1	-0.3
Medication: Aspirin	0.0	0.1	0.1	0.3	0.2
Average weekly champagne plus white wine intake	0.0	0.0	0.0	-0.2	-0.2
Irritability	0.0	0.1	0.1	-0.3	0.2
Diastolic blood pressure, automated reading	0.0	0.0	0.1	-0.0	0.3
Unable to work because of sickness or disability	0.0	0.0	0.1	-0.0	-0.3

Hub : Genes

WNT7A

Models

Trait associations