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chr1:31,402,148-34,592,020

Best TWAS P=3.24e-23 · Best GWAS P=8.11e-27 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PTP4A2	0.09	-0.01	blup	26	0.00	4.1e-01	7.50	9.9	3.2e-23	0.80	0.01	0.56	TRUE
4	GTEx	Artery Aorta	PEF1	0.15	0.05	lasso	5	0.04	2.2e-03	-6.40	7.4	1.3e-13	0.10	0.51	0.02	TRUE
15	ROSMAP	Brain Pre-frontal Cortex	KPNA6	0.03	0.04	lasso	4	0.02	8.1e-04	6.91	7.2	6.9e-13	0.42	0.60	0.22	TRUE
3	CommonMind	Brain Pre-frontal Cortex	ZNF362	0.05	0.06	lasso	1	0.06	2.2e-07	-7.17	-7.2	7.6e-13	-0.09	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Thyroid Carcinoma	KPNA6	0.03	0.03	blup	28	0.03	5.3e-04	7.19	6.8	1.1e-11	0.34	0.02	0.90	TRUE
6	GTEx	Cells EBV-transformed lymphocytes	KPNA6	0.19	0.14	enet	18	0.10	4.9e-04	6.93	6.7	1.8e-11	0.36	0.22	0.05	TRUE
22	The Cancer Genome Atlas	Lung Adenocarcinoma	MTMR9L	0.03	0.00	blup	30	0.01	1.0e-02	4.09	6.3	2.5e-10	0.32	0.01	0.60	TRUE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	MTMR9L	0.04	0.04	blup	29	0.02	1.0e-03	4.20	6.2	5.3e-10	0.40	0.19	0.45	TRUE
28	The Cancer Genome Atlas	Thyroid Carcinoma	MTMR9L	0.03	0.04	blup	28	0.03	3.3e-04	4.09	6.2	7.4e-10	0.38	0.03	0.91	TRUE
10	GTEx	Nerve Tibial	TXLNA	0.10	0.00	enet	5	0.00	6.8e-01	-2.34	-5.8	7.6e-09	-0.32	0.04	0.04	TRUE
23	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TMEM39B	0.05	0.04	enet	9	0.05	1.7e-04	6.96	-5.3	8.7e-08	-0.22	0.01	0.82	TRUE
5	GTEx	Brain Caudate basal ganglia	FAM167B	0.43	0.00	lasso	11	0.00	3.0e-01	-0.73	5.2	1.7e-07	0.34	0.02	0.21	TRUE
17	YFS	Blood	KPNA6	0.03	0.03	bslmm	236	0.04	1.1e-11	7.19	7.6	3.1e-14	0.40	1.00	0.00	FALSE
14	METSIM	Adipose	KPNA6	0.07	0.06	lasso	10	0.06	1.8e-09	6.97	7.2	5.3e-13	0.40	1.00	0.00	FALSE
13	GTEx	Testis	RP4-622L5.7	0.12	0.11	lasso	5	0.08	2.3e-04	6.98	7.0	2.9e-12	0.38	0.35	0.13	FALSE
8	GTEx	Cells Transformed fibroblasts	KPNA6	0.13	0.10	lasso	5	0.11	1.3e-08	6.97	7.0	3.6e-12	0.38	1.00	0.00	FALSE
11	GTEx	Skin Not Sun Exposed Suprapubic	EIF3I	0.12	0.06	lasso	1	0.03	7.2e-03	6.89	-6.9	5.6e-12	-0.38	0.09	0.04	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	KPNA6	0.02	0.02	blup	29	0.02	1.9e-03	6.88	6.8	1.1e-11	0.36	0.02	0.84	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	PHC2	0.11	0.07	lasso	3	0.05	2.2e-07	-6.90	-6.5	5.8e-11	-0.09	0.01	0.99	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	PHC2	0.58	0.34	lasso	7	0.28	7.3e-10	-6.90	6.5	6.1e-11	0.10	0.02	0.98	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MTMR9L	0.03	0.03	blup	28	0.01	1.6e-02	4.34	6.4	1.8e-10	0.39	0.04	0.54	FALSE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM39B	0.04	0.03	blup	16	0.03	5.0e-04	6.97	-6.2	5.8e-10	-0.31	0.01	0.94	FALSE
24	The Cancer Genome Atlas	Skin Cutaneous Melanoma	MTMR9L	0.15	0.02	blup	29	0.09	2.8e-03	2.83	6.1	8.8e-10	0.35	0.01	0.39	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	FAM167B	0.03	0.01	blup	26	0.02	2.4e-03	4.34	-5.6	2.0e-08	-0.37	0.02	0.74	FALSE
9	GTEx	Colon Sigmoid	PEF1	0.16	0.09	lasso	3	0.09	4.3e-04	-4.40	5.5	3.0e-08	0.06	0.21	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TXLNA	0.04	0.04	bslmm	221	0.03	1.8e-04	6.98	-5.5	4.5e-08	-0.20	0.84	0.01	FALSE
1	CommonMind	Brain Pre-frontal Cortex	TMEM54	0.05	0.00	blup	281	0.02	4.5e-03	0.24	-5.2	1.5e-07	-0.07	0.11	0.27	FALSE
12	GTEx	Skin Sun Exposed Lower leg	PEF1	0.05	0.03	enet	9	0.02	4.6e-03	-6.40	5.2	2.0e-07	0.10	0.66	0.01	FALSE