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chr1:24,894,997-27,971,502

Best TWAS P=4.88e-22 · Best GWAS P=2.78e-24 conditioned to 0.000687

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	PDIK1L	0.03	0.01	blup	37	0.02	2.6e-03	7.98	-9.7	4.9e-22	0.05	0.01	0.59	TRUE
10	GTEx	Esophagus Mucosa	DHDDS	0.11	0.06	lasso	4	0.04	6.6e-04	-9.90	-8.9	3.4e-19	0.60	0.04	0.93	TRUE
13	GTEx	Nerve Tibial	NUDC	0.12	0.00	lasso	6	0.01	1.2e-01	5.81	7.6	3.3e-14	-0.27	0.03	0.39	TRUE
20	GTEx	Spleen	PIGV	0.16	0.13	lasso	13	0.16	6.6e-05	5.85	-6.9	6.7e-12	0.09	0.31	0.06	TRUE
5	GTEx	Breast Mammary Tissue (Female)	RP11-335G20.7	0.47	0.19	enet	23	0.10	9.0e-04	-4.43	-5.8	6.8e-09	-0.03	0.66	0.06	TRUE
3	GTEx	Artery Tibial	CEP85	0.18	0.02	lasso	3	0.04	6.2e-04	-3.17	-5.3	9.6e-08	0.09	0.53	0.07	TRUE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRIM63	0.29	0.33	enet	20	0.33	2.5e-38	8.98	9.6	1.0e-21	-0.07	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PDIK1L	0.02	0.02	blup	37	0.02	2.8e-03	9.02	-9.2	3.7e-20	0.08	0.01	0.86	FALSE
30	The Cancer Genome Atlas	Breast Invasive Carcinoma	TRIM63	0.15	0.16	lasso	2	0.16	2.3e-32	8.96	9.0	2.4e-19	-0.07	0.00	1.00	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TRIM63	0.16	0.11	lasso	1	0.10	2.0e-11	8.98	9.0	2.7e-19	-0.08	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	TRIM63	0.14	0.15	lasso	1	0.14	2.2e-07	8.90	8.9	5.4e-19	-0.07	0.01	0.99	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	TRIM63	0.08	0.10	lasso	4	0.10	3.7e-06	8.98	8.9	6.4e-19	-0.08	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	TRIM63	0.18	0.26	enet	7	0.26	3.0e-25	8.77	8.9	7.8e-19	-0.07	0.01	0.99	FALSE
11	GTEx	Esophagus Mucosa	PDIK1L	0.10	0.09	lasso	6	0.09	8.8e-07	8.95	-8.8	1.0e-18	0.10	0.96	0.01	FALSE
27	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	TRIM63	0.03	0.02	blup	33	0.02	4.6e-03	8.96	8.8	1.1e-18	-0.08	0.01	0.89	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	TRIM63	0.14	0.20	enet	7	0.21	9.4e-24	8.77	8.7	2.7e-18	-0.08	0.01	0.99	FALSE
43	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TRIM63	0.14	0.18	lasso	7	0.15	3.0e-10	8.76	8.6	7.8e-18	-0.07	0.02	0.98	FALSE
22	GTEx	Thyroid	CNKSR1	0.10	0.04	lasso	7	0.03	2.1e-03	7.78	-8.4	5.3e-17	0.15	0.74	0.12	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TRIM63	0.11	0.11	enet	4	0.12	9.0e-14	8.98	8.2	2.1e-16	-0.07	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TRIM63	0.19	0.07	blup	33	0.14	1.3e-04	8.98	8.2	3.1e-16	-0.06	0.01	0.99	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RPS6KA1	0.11	0.05	lasso	6	0.07	8.0e-04	-8.69	8.0	9.4e-16	-0.73	0.01	0.86	FALSE
14	GTEx	Nerve Tibial	PDIK1L	0.09	0.01	enet	10	0.03	2.2e-03	7.42	-7.9	3.3e-15	0.15	0.73	0.04	FALSE
35	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SLC30A2	0.03	0.02	lasso	3	0.01	1.1e-02	5.66	-7.3	3.2e-13	0.08	0.02	0.90	FALSE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	TRIM63	0.28	0.22	lasso	3	0.20	1.7e-05	5.66	7.1	9.1e-13	-0.07	0.02	0.89	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	SH3BGRL3	0.05	0.03	lasso	2	0.03	9.3e-04	6.28	7.1	1.3e-12	-0.18	0.00	0.94	FALSE
24	GTEx	Whole Blood	CEP85	0.07	0.01	enet	17	0.02	1.3e-02	-1.99	-7.0	2.1e-12	0.07	0.27	0.04	FALSE
41	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PDIK1L	0.02	0.00	blup	37	0.02	1.2e-03	4.94	-7.0	2.8e-12	0.09	0.02	0.75	FALSE
15	GTEx	Pancreas	CNKSR1	0.20	0.03	enet	20	0.04	7.3e-03	6.99	-6.9	6.0e-12	0.27	0.12	0.10	FALSE
29	The Cancer Genome Atlas	Breast Invasive Carcinoma	PDIK1L	0.02	0.01	blup	37	0.02	6.1e-05	9.02	-6.8	1.4e-11	0.09	0.02	0.95	FALSE
19	GTEx	Skin Sun Exposed Lower leg	PDIK1L	0.14	0.05	enet	23	0.12	3.1e-10	8.96	-6.7	2.5e-11	0.15	0.99	0.01	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	NUDC	0.18	0.15	enet	17	0.22	2.1e-28	5.10	6.6	3.2e-11	-0.12	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CNKSR1	0.11	0.03	blup	57	0.05	3.5e-06	7.78	-6.6	4.7e-11	0.10	0.14	0.56	FALSE
7	GTEx	Cells Transformed fibroblasts	RP1-125I3.2	0.06	0.04	enet	19	0.03	3.3e-03	6.28	-6.5	6.6e-11	0.18	0.08	0.46	FALSE
12	GTEx	Muscle Skeletal	PIGV	0.07	0.01	enet	12	0.02	2.1e-03	5.02	-6.5	6.8e-11	0.18	0.50	0.02	FALSE
18	GTEx	Skin Not Sun Exposed Suprapubic	PDIK1L	0.22	0.05	enet	37	0.11	8.3e-07	8.95	-6.3	3.7e-10	0.15	0.98	0.01	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	CNKSR1	0.15	0.10	lasso	7	0.09	1.0e-05	4.10	-6.2	6.2e-10	0.10	0.93	0.00	FALSE
23	GTEx	Thyroid	SEPN1	0.10	0.03	lasso	3	0.04	7.0e-04	-4.16	-6.1	9.2e-10	0.00	0.89	0.01	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	FAM54B	0.06	0.01	blup	63	0.04	1.8e-09	5.05	-6.0	2.7e-09	0.03	0.01	0.98	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	NUDC	0.08	0.01	blup	34	0.03	4.4e-04	0.79	5.9	3.2e-09	-0.09	0.00	0.04	FALSE
8	GTEx	Colon Sigmoid	PIGV	0.18	0.03	enet	37	0.04	1.5e-02	5.05	-5.9	4.0e-09	0.21	0.22	0.06	FALSE
48	The Cancer Genome Atlas	Rectum Adenocarcinoma	EXTL1	0.14	0.03	blup	46	0.05	2.2e-02	4.09	-5.9	4.0e-09	0.05	0.02	0.40	FALSE
33	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GRRP1	0.11	0.02	blup	52	0.03	8.8e-05	-4.12	5.8	7.1e-09	0.01	0.02	0.29	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NUDC	0.05	0.03	bslmm	257	0.03	7.4e-05	5.11	5.7	1.1e-08	-0.02	0.76	0.01	FALSE
16	GTEx	Pituitary	CNKSR1	0.38	0.16	lasso	7	0.15	1.4e-04	4.09	-5.6	1.9e-08	0.12	0.33	0.04	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	MTFR1L	0.23	0.25	lasso	5	0.30	7.4e-39	-4.24	-5.4	8.0e-08	0.00	1.00	0.00	FALSE
4	GTEx	Brain Cortex	CNKSR1	0.46	0.23	enet	33	0.31	3.5e-09	-1.97	5.4	8.3e-08	-0.06	0.84	0.01	FALSE
2	GTEx	Artery Aorta	PIGV	0.11	0.10	lasso	9	0.08	2.7e-05	5.02	-5.3	1.0e-07	0.04	0.93	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Female)	RP3-465N24.5	0.12	0.00	lasso	2	0.00	3.8e-01	-4.37	-5.3	1.1e-07	0.01	0.04	0.06	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	FAM54B	0.11	0.03	blup	63	0.09	3.3e-06	-3.72	-5.3	1.3e-07	-0.01	0.03	0.89	FALSE
21	GTEx	Thyroid	DHDDS	0.14	0.08	enet	22	0.07	5.8e-06	5.18	-5.2	1.8e-07	0.52	0.61	0.11	FALSE
9	GTEx	Colon Transverse	CNKSR1	0.14	0.00	enet	21	0.00	2.0e-01	-4.19	5.2	2.4e-07	0.04	0.12	0.08	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	FAM54B	0.08	0.08	enet	4	0.07	4.0e-08	5.02	-5.2	2.5e-07	0.04	0.00	0.99	FALSE