[Hub]/) : Traits : Standing height :

chr4:6,663,260-8,731,330

Best TWAS P=3.49e-15 · Best GWAS P=3.29e-21 conditioned to 1.18e-08

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adrenal Gland ACOX3 0.15 0.12 lasso 6 0.13 2.5e-05 -5.27 -5.3 9.4e-08 0.07 0.70 0.02 FALSE
2 GTEx Brain Cerebellar Hemisphere TRMT44 0.41 0.26 lasso 5 0.20 5.8e-06 -5.72 -5.7 1.3e-08 0.08 0.79 0.01 FALSE
3 GTEx Brain Cerebellar Hemisphere AFAP1 0.60 0.28 lasso 11 0.34 1.1e-09 7.24 6.1 1.0e-09 -0.01 0.03 0.96 FALSE
4 GTEx Brain Cerebellar Hemisphere AFAP1-AS1 0.33 0.16 lasso 7 0.16 5.9e-05 7.24 6.7 1.9e-11 0.00 0.04 0.89 FALSE
5 GTEx Brain Cerebellum AFAP1 0.47 0.19 lasso 4 0.19 2.8e-06 -4.95 6.8 9.6e-12 0.00 0.04 0.92 TRUE
6 GTEx Brain Cerebellum AFAP1-AS1 0.47 0.05 lasso 10 0.10 7.6e-04 3.42 6.2 4.0e-10 0.01 0.05 0.67 FALSE
7 GTEx Brain Hypothalamus TRMT44 0.38 0.19 lasso 5 0.13 6.1e-04 -5.70 -5.2 1.8e-07 0.05 0.46 0.03 FALSE
8 GTEx Brain Nucleus accumbens basal ganglia TRMT44 0.25 0.19 lasso 5 0.17 2.1e-05 -5.56 -5.4 7.0e-08 0.08 0.40 0.03 FALSE
9 GTEx Breast Mammary Tissue TRMT44 0.19 0.22 lasso 5 0.20 2.2e-10 -5.48 -5.3 1.2e-07 0.07 1.00 0.00 FALSE
10 GTEx Breast Mammary Tissue (Male) TRMT44 0.22 0.03 lasso 8 0.01 2.1e-01 -4.54 -5.4 8.3e-08 0.10 0.07 0.06 FALSE
11 GTEx Breast Mammary Tissue (Female) RP11-689P11.3 0.12 0.07 lasso 2 0.08 2.5e-03 -5.72 -5.3 9.1e-08 0.07 0.14 0.06 FALSE
12 GTEx Cells Transformed fibroblasts ACOX3 0.25 0.14 lasso 7 0.14 1.6e-10 -5.72 -5.6 1.7e-08 0.08 1.00 0.00 FALSE
13 GTEx Cells Transformed fibroblasts AFAP1 0.26 0.10 enet 39 0.13 3.6e-10 -4.01 -5.5 3.8e-08 -0.02 0.01 0.99 FALSE
14 GTEx Cells Transformed fibroblasts AFAP1-AS1 0.20 0.09 enet 31 0.07 4.7e-06 -7.82 -5.4 5.7e-08 -0.05 0.00 1.00 FALSE
15 GTEx Colon Transverse TRMT44 0.17 0.05 lasso 5 0.02 4.4e-02 -5.48 -5.7 1.4e-08 0.09 0.24 0.04 FALSE
16 GTEx Esophagus Mucosa AFAP1 0.48 0.40 enet 29 0.43 3.9e-31 5.47 5.9 4.3e-09 -0.02 0.77 0.23 FALSE
17 GTEx Esophagus Mucosa AFAP1-AS1 0.36 0.28 lasso 8 0.29 5.9e-20 5.43 5.4 6.5e-08 -0.02 0.66 0.34 FALSE
18 GTEx Nerve Tibial TRMT44 0.27 0.26 lasso 5 0.27 5.4e-19 -5.56 -5.2 2.1e-07 0.08 1.00 0.00 FALSE
19 GTEx Ovary TRMT44 0.33 0.32 lasso 3 0.29 6.2e-08 -5.16 -5.6 1.7e-08 0.05 0.83 0.01 FALSE
20 GTEx Skin Not Sun Exposed Suprapubic AFAP1 0.47 0.46 lasso 4 0.45 2.8e-27 5.47 5.5 3.4e-08 -0.02 0.99 0.01 FALSE
21 GTEx Skin Not Sun Exposed Suprapubic AFAP1-AS1 0.33 0.30 lasso 6 0.29 4.0e-16 5.47 5.5 4.3e-08 -0.03 0.98 0.02 FALSE
22 GTEx Skin Sun Exposed Lower leg TRMT44 0.08 0.04 lasso 4 0.02 1.7e-02 -5.70 -5.1 2.9e-07 0.06 0.48 0.02 FALSE
23 GTEx Skin Sun Exposed Lower leg AFAP1 0.50 0.45 lasso 8 0.46 4.2e-42 5.47 5.4 5.8e-08 -0.02 1.00 0.00 FALSE
24 GTEx Skin Sun Exposed Lower leg AFAP1-AS1 0.34 0.26 lasso 5 0.24 8.3e-20 5.47 5.5 4.9e-08 -0.01 0.88 0.12 FALSE
25 GTEx Whole Blood AFAP1 0.45 0.48 enet 44 0.50 1.3e-52 5.47 5.5 4.5e-08 -0.01 0.99 0.01 FALSE
26 GTEx Whole Blood AFAP1-AS1 0.36 0.33 lasso 8 0.33 2.6e-31 5.47 5.9 4.3e-09 -0.01 0.72 0.28 FALSE
27 METSIM Adipose AFAP1 0.05 0.03 enet 13 0.03 1.3e-05 5.47 6.0 2.3e-09 -0.01 0.07 0.93 FALSE
28 The Cancer Genome Atlas Breast Invasive Carcinoma FLJ36777 0.04 0.02 blup 71 0.03 2.4e-07 -5.02 5.3 1.0e-07 -0.04 0.02 0.98 FALSE
29 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CPZ 0.03 0.00 blup 80 0.01 1.9e-02 -4.84 7.9 3.5e-15 -0.55 0.03 0.24 TRUE
30 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma TADA2B 0.02 0.01 blup 56 0.02 1.9e-03 -5.00 -5.6 2.1e-08 0.06 0.04 0.65 TRUE
31 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CPZ 0.09 0.01 blup 80 0.03 4.4e-04 -0.74 6.8 1.4e-11 -0.54 0.02 0.44 FALSE
32 The Cancer Genome Atlas Prostate Adenocarcinoma CPZ 0.10 0.12 lasso 4 0.13 3.1e-13 5.29 5.3 9.9e-08 -0.49 0.95 0.05 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma GRPEL1 0.05 0.04 blup 52 0.05 9.0e-06 -3.56 -5.4 7.5e-08 0.06 0.16 0.83 FALSE
34 The Cancer Genome Atlas Thyroid Carcinoma TBC1D14 0.06 0.04 lasso 2 0.05 7.6e-06 -5.04 5.5 4.6e-08 -0.03 0.04 0.94 FALSE