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chr4:6,663,260-8,731,330

Best TWAS P=3.49e-15 · Best GWAS P=3.29e-21 conditioned to 1.18e-08

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adrenal Gland	ACOX3	0.15	0.12	lasso	6	0.13	2.5e-05	-5.27	-5.3	9.4e-08	0.07	0.70	0.02	FALSE
2	GTEx	Brain Cerebellar Hemisphere	TRMT44	0.41	0.26	lasso	5	0.20	5.8e-06	-5.72	-5.7	1.3e-08	0.08	0.79	0.01	FALSE
3	GTEx	Brain Cerebellar Hemisphere	AFAP1	0.60	0.28	lasso	11	0.34	1.1e-09	7.24	6.1	1.0e-09	-0.01	0.03	0.96	FALSE
4	GTEx	Brain Cerebellar Hemisphere	AFAP1-AS1	0.33	0.16	lasso	7	0.16	5.9e-05	7.24	6.7	1.9e-11	0.00	0.04	0.89	FALSE
5	GTEx	Brain Cerebellum	AFAP1	0.47	0.19	lasso	4	0.19	2.8e-06	-4.95	6.8	9.6e-12	0.00	0.04	0.92	TRUE
6	GTEx	Brain Cerebellum	AFAP1-AS1	0.47	0.05	lasso	10	0.10	7.6e-04	3.42	6.2	4.0e-10	0.01	0.05	0.67	FALSE
7	GTEx	Brain Hypothalamus	TRMT44	0.38	0.19	lasso	5	0.13	6.1e-04	-5.70	-5.2	1.8e-07	0.05	0.46	0.03	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	TRMT44	0.25	0.19	lasso	5	0.17	2.1e-05	-5.56	-5.4	7.0e-08	0.08	0.40	0.03	FALSE
9	GTEx	Breast Mammary Tissue	TRMT44	0.19	0.22	lasso	5	0.20	2.2e-10	-5.48	-5.3	1.2e-07	0.07	1.00	0.00	FALSE
10	GTEx	Breast Mammary Tissue (Male)	TRMT44	0.22	0.03	lasso	8	0.01	2.1e-01	-4.54	-5.4	8.3e-08	0.10	0.07	0.06	FALSE
11	GTEx	Breast Mammary Tissue (Female)	RP11-689P11.3	0.12	0.07	lasso	2	0.08	2.5e-03	-5.72	-5.3	9.1e-08	0.07	0.14	0.06	FALSE
12	GTEx	Cells Transformed fibroblasts	ACOX3	0.25	0.14	lasso	7	0.14	1.6e-10	-5.72	-5.6	1.7e-08	0.08	1.00	0.00	FALSE
13	GTEx	Cells Transformed fibroblasts	AFAP1	0.26	0.10	enet	39	0.13	3.6e-10	-4.01	-5.5	3.8e-08	-0.02	0.01	0.99	FALSE
14	GTEx	Cells Transformed fibroblasts	AFAP1-AS1	0.20	0.09	enet	31	0.07	4.7e-06	-7.82	-5.4	5.7e-08	-0.05	0.00	1.00	FALSE
15	GTEx	Colon Transverse	TRMT44	0.17	0.05	lasso	5	0.02	4.4e-02	-5.48	-5.7	1.4e-08	0.09	0.24	0.04	FALSE
16	GTEx	Esophagus Mucosa	AFAP1	0.48	0.40	enet	29	0.43	3.9e-31	5.47	5.9	4.3e-09	-0.02	0.77	0.23	FALSE
17	GTEx	Esophagus Mucosa	AFAP1-AS1	0.36	0.28	lasso	8	0.29	5.9e-20	5.43	5.4	6.5e-08	-0.02	0.66	0.34	FALSE
18	GTEx	Nerve Tibial	TRMT44	0.27	0.26	lasso	5	0.27	5.4e-19	-5.56	-5.2	2.1e-07	0.08	1.00	0.00	FALSE
19	GTEx	Ovary	TRMT44	0.33	0.32	lasso	3	0.29	6.2e-08	-5.16	-5.6	1.7e-08	0.05	0.83	0.01	FALSE
20	GTEx	Skin Not Sun Exposed Suprapubic	AFAP1	0.47	0.46	lasso	4	0.45	2.8e-27	5.47	5.5	3.4e-08	-0.02	0.99	0.01	FALSE
21	GTEx	Skin Not Sun Exposed Suprapubic	AFAP1-AS1	0.33	0.30	lasso	6	0.29	4.0e-16	5.47	5.5	4.3e-08	-0.03	0.98	0.02	FALSE
22	GTEx	Skin Sun Exposed Lower leg	TRMT44	0.08	0.04	lasso	4	0.02	1.7e-02	-5.70	-5.1	2.9e-07	0.06	0.48	0.02	FALSE
23	GTEx	Skin Sun Exposed Lower leg	AFAP1	0.50	0.45	lasso	8	0.46	4.2e-42	5.47	5.4	5.8e-08	-0.02	1.00	0.00	FALSE
24	GTEx	Skin Sun Exposed Lower leg	AFAP1-AS1	0.34	0.26	lasso	5	0.24	8.3e-20	5.47	5.5	4.9e-08	-0.01	0.88	0.12	FALSE
25	GTEx	Whole Blood	AFAP1	0.45	0.48	enet	44	0.50	1.3e-52	5.47	5.5	4.5e-08	-0.01	0.99	0.01	FALSE
26	GTEx	Whole Blood	AFAP1-AS1	0.36	0.33	lasso	8	0.33	2.6e-31	5.47	5.9	4.3e-09	-0.01	0.72	0.28	FALSE
27	METSIM	Adipose	AFAP1	0.05	0.03	enet	13	0.03	1.3e-05	5.47	6.0	2.3e-09	-0.01	0.07	0.93	FALSE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	FLJ36777	0.04	0.02	blup	71	0.03	2.4e-07	-5.02	5.3	1.0e-07	-0.04	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CPZ	0.03	0.00	blup	80	0.01	1.9e-02	-4.84	7.9	3.5e-15	-0.55	0.03	0.24	TRUE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TADA2B	0.02	0.01	blup	56	0.02	1.9e-03	-5.00	-5.6	2.1e-08	0.06	0.04	0.65	TRUE
31	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CPZ	0.09	0.01	blup	80	0.03	4.4e-04	-0.74	6.8	1.4e-11	-0.54	0.02	0.44	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	CPZ	0.10	0.12	lasso	4	0.13	3.1e-13	5.29	5.3	9.9e-08	-0.49	0.95	0.05	FALSE
33	The Cancer Genome Atlas	Prostate Adenocarcinoma	GRPEL1	0.05	0.04	blup	52	0.05	9.0e-06	-3.56	-5.4	7.5e-08	0.06	0.16	0.83	FALSE
34	The Cancer Genome Atlas	Thyroid Carcinoma	TBC1D14	0.06	0.04	lasso	2	0.05	7.6e-06	-5.04	5.5	4.6e-08	-0.03	0.04	0.94	FALSE