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chr1:43,042,125-45,157,738

Best TWAS P=3.04e-15 · Best GWAS P=2.86e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	GTEx	Thyroid	ARTN	0.07	0.04	lasso	3	0.03	1.2e-03	-8.5	-7.9	3.0e-15	0.57	0.25	0.35	TRUE
18	GTEx	Muscle Skeletal	ST3GAL3	0.10	0.01	enet	27	0.01	1.6e-02	7.3	-7.2	4.3e-13	0.62	0.07	0.87	TRUE
3	GTEx	Adipose Visceral Omentum	HYI	0.35	0.23	enet	25	0.24	2.0e-12	-5.8	-6.2	4.0e-10	0.38	1.00	0.00	TRUE
32	YFS	Blood	CCDC24	0.36	0.43	lasso	7	0.44	6.5e-160	-6.2	-6.1	8.9e-10	0.33	1.00	0.00	TRUE
41	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ARTN	0.08	0.10	lasso	1	0.08	3.7e-04	-6.1	-6.0	1.4e-09	0.30	0.04	0.62	TRUE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	HYI	0.22	0.14	lasso	2	0.14	1.6e-14	-5.8	-5.8	6.3e-09	0.45	0.48	0.52	TRUE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	HYI	0.12	0.07	enet	4	0.06	1.2e-07	-5.6	-5.6	2.1e-08	0.41	0.18	0.82	TRUE
40	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	HYI	0.26	0.15	lasso	3	0.13	3.7e-06	-5.6	-5.5	3.2e-08	0.37	0.02	0.96	TRUE
28	ROSMAP	Brain Pre-frontal Cortex	ARTN	0.14	0.19	lasso	4	0.18	3.0e-23	-5.3	-5.3	1.1e-07	0.27	1.00	0.00	TRUE
12	GTEx	Cells Transformed fibroblasts	CCDC24	0.07	0.00	enet	16	0.02	9.5e-03	-6.6	-5.2	1.7e-07	0.54	0.09	0.59	TRUE
27	METSIM	Adipose	ARTN	0.05	0.04	bslmm	412	0.03	1.3e-05	-6.5	-7.7	9.6e-15	0.47	0.73	0.26	FALSE
20	GTEx	Nerve Tibial	MED8	0.13	0.07	enet	11	0.16	3.6e-11	4.1	7.6	2.5e-14	-0.61	0.80	0.20	FALSE
19	GTEx	Muscle Skeletal	RP11-7O11.3	0.05	0.02	lasso	3	0.02	7.2e-03	-8.5	7.4	1.3e-13	-0.60	0.09	0.42	FALSE
2	GTEx	Adipose Subcutaneous	HYI	0.38	0.09	lasso	9	0.07	1.6e-06	-5.7	-7.4	1.4e-13	0.53	0.99	0.00	FALSE
42	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	PTPRF	0.07	0.01	blup	85	0.04	1.3e-02	-5.4	7.3	2.4e-13	-0.77	0.02	0.78	FALSE
7	GTEx	Brain Cerebellum	ARTN	0.47	0.33	lasso	5	0.43	6.0e-14	-5.9	-7.3	3.7e-13	0.53	0.93	0.06	FALSE
39	The Cancer Genome Atlas	Lung Adenocarcinoma	KDM4A	0.03	0.02	enet	5	0.02	1.5e-03	3.1	7.1	1.2e-12	-0.71	0.03	0.52	FALSE
8	GTEx	Brain Cortex	ARTN	0.13	0.04	lasso	5	0.03	5.9e-02	-7.7	-7.0	1.8e-12	0.63	0.13	0.42	FALSE
1	CommonMind	Brain Pre-frontal Cortex	MED8	0.04	0.00	blup	455	0.01	1.1e-02	-8.7	7.0	3.3e-12	-0.63	0.05	0.62	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPH2	0.03	0.03	enet	7	0.04	5.8e-05	-5.4	-6.8	9.9e-12	0.41	0.06	0.90	FALSE
10	GTEx	Breast Mammary Tissue (Female)	ST3GAL3	0.03	-0.01	lasso	2	0.01	1.6e-01	-6.6	-6.6	3.2e-11	0.28	0.05	0.06	FALSE
15	GTEx	Heart Left Ventricle	MED8	0.08	0.01	lasso	3	0.01	1.2e-01	7.3	-6.4	1.2e-10	0.40	0.19	0.07	FALSE
17	GTEx	Muscle Skeletal	B4GALT2	0.04	0.05	lasso	2	0.03	6.4e-04	-6.4	6.4	1.5e-10	-0.38	0.21	0.26	FALSE
22	GTEx	Stomach	HYI	0.16	0.06	lasso	6	0.07	4.1e-04	-5.6	-6.4	1.5e-10	0.56	0.31	0.30	FALSE
45	The Cancer Genome Atlas	Rectum Adenocarcinoma	HYI	0.23	0.08	blup	34	0.14	3.1e-04	-5.8	-6.4	1.5e-10	0.49	0.00	0.87	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA0467	0.07	0.03	enet	5	0.04	7.5e-05	-5.7	-6.4	2.0e-10	0.55	0.03	0.95	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	HYI	0.35	0.35	lasso	7	0.36	8.6e-48	-5.8	-6.2	4.5e-10	0.45	1.00	0.00	FALSE
6	GTEx	Brain Cerebellar Hemisphere	ARTN	0.45	0.36	enet	29	0.40	2.5e-11	-5.3	-6.1	1.1e-09	0.37	0.91	0.03	FALSE
14	GTEx	Heart Left Ventricle	TIE1	0.22	0.04	lasso	11	0.04	5.3e-03	4.5	-6.1	1.2e-09	0.35	0.84	0.02	FALSE
21	GTEx	Pancreas	HYI	0.22	0.16	enet	9	0.20	9.7e-09	-5.8	-6.0	1.8e-09	0.49	0.97	0.00	FALSE
23	GTEx	Testis	MED8	0.21	0.14	lasso	3	0.20	1.8e-09	-5.6	-5.9	2.8e-09	0.43	0.99	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	TMEM125	0.02	0.01	lasso	4	0.01	7.4e-03	4.6	-5.9	3.5e-09	0.34	0.36	0.02	FALSE
26	GTEx	Thyroid	HYI	0.16	0.13	lasso	6	0.12	1.2e-09	-5.8	-5.9	4.0e-09	0.46	1.00	0.00	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	HYI	0.09	0.05	lasso	2	0.05	5.1e-10	-5.8	-5.8	5.5e-09	0.43	0.54	0.46	FALSE
47	The Cancer Genome Atlas	Thyroid Carcinoma	HYI	0.28	0.22	lasso	2	0.23	5.3e-22	-5.6	-5.8	6.3e-09	0.42	0.61	0.39	FALSE
46	The Cancer Genome Atlas	Testicular Germ Cell Tumors	HYI	0.24	0.16	lasso	2	0.12	5.7e-05	-5.8	-5.8	8.4e-09	0.45	0.04	0.87	FALSE
29	ROSMAP	Brain Pre-frontal Cortex	PTPRF	0.05	0.01	blup	483	0.04	4.1e-06	1.2	5.7	1.1e-08	-0.55	0.19	0.79	FALSE
38	The Cancer Genome Atlas	Lung Adenocarcinoma	HYI	0.06	0.03	enet	4	0.03	1.2e-04	-5.8	-5.7	1.4e-08	0.44	0.12	0.81	FALSE
5	GTEx	Artery Tibial	HYI	0.15	0.09	lasso	4	0.12	6.3e-10	-5.6	-5.6	1.7e-08	0.36	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C1orf84	0.05	0.04	lasso	1	0.03	7.6e-05	-5.6	-5.6	2.2e-08	0.45	0.00	0.99	FALSE
4	GTEx	Artery Aorta	MED8	0.10	0.05	enet	13	0.08	4.6e-05	4.6	5.6	2.4e-08	-0.36	0.88	0.02	FALSE
34	The Cancer Genome Atlas	Colon Adenocarcinoma	HYI	0.10	0.05	enet	5	0.09	1.1e-05	-5.6	-5.5	4.2e-08	0.29	0.12	0.69	FALSE
16	GTEx	Lung	HYI	0.18	0.04	enet	22	0.06	1.8e-05	3.7	-5.4	6.4e-08	0.31	0.97	0.00	FALSE
9	GTEx	Breast Mammary Tissue (Female)	TIE1	0.10	0.07	enet	10	0.07	3.5e-03	6.0	-5.4	6.5e-08	0.32	0.17	0.05	FALSE
24	GTEx	Thyroid	TIE1	0.10	0.05	lasso	3	0.05	1.3e-04	4.3	-5.4	6.6e-08	0.37	0.74	0.01	FALSE
13	GTEx	Colon Transverse	HYI	0.16	0.05	lasso	6	0.09	6.9e-05	-5.6	-5.3	9.0e-08	0.36	0.36	0.07	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	TIE1	0.03	0.03	blup	46	0.03	6.1e-04	4.7	-5.2	1.9e-07	0.33	0.07	0.85	FALSE
11	GTEx	Cells Transformed fibroblasts	PTPRF	0.08	0.08	lasso	3	0.06	2.2e-05	-5.1	5.2	2.5e-07	-0.62	0.20	0.72	FALSE