TWAS hub - PART1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1820	0.0410	2.5e-13	0.121	0.133	0.152	0.144	0.154	1.8e-14	7.9e-16	4.9e-18	4.2e-17	2.6e-18
2	ROSMAP	Brain Pre-frontal Cortex	0.0907	0.0314	2.1e-06	0.039	0.061	0.058	0.061	0.071	7.5e-06	2.7e-08	5.7e-08	2.6e-08	2.1e-09
3	TCGA	Thyroid Carcinoma	0.1450	0.0470	1.4e-07	0.030	0.068	0.075	NA	0.049	6.2e-04	3.8e-07	9.3e-08	NA	1.4e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Qualifications: College or University degree	6.6	20.7	33.4	-5.8	-4.3	-3.3
Commuting to job workplace: Public transport	6.1	7.3	10.0	-2.7	-3.2	-2.2
Qualifications: nursing, teaching	5.7	8.9	11.6	-3.4	-3.0	-2.4
Family relationship satisfaction	5.6	6.9	8.2	-2.8	-2.9	-2.1
Prospective memory result	5.4	6.7	11.8	2.1	2.0	3.4
Commuting to job workplace: Car/motor vehicle	5.4	6.1	13.2	1.8	3.6	1.4
Medication: Co-codamol	4.3	5.0	8.4	2.1	2.9	1.4
Diabetes (mother)	4.2	5.3	7.0	2.2	2.0	2.6
Qualifications: NVQ or HND or HNC or equivalent	4.1	4.9	7.0	2.6	2.5	1.3
Reason for reducing amount of alcohol drunk: Health precaution	3.6	4.2	6.7	-1.3	-2.1	-2.6
Worrier / anxious feelings	3.5	6.6	12.0	-2.4	-1.4	-3.5
Loneliness, isolation	3.4	4.7	6.1	-2.1	-1.8	-2.5
Health satisfaction	3.2	4.2	5.8	2.4	2.3	1.3
Shortness of breath walking on level ground	3.2	3.8	4.8	2.2	2.0	1.7
Fluid intelligence score	3.0	6.2	9.4	-3.1	-0.6	-3.0
Medication: Seretide 50 evohaler	2.9	3.3	4.7	1.8	1.4	2.2
Eye problems/disorders: Diabetes related eye disease	2.8	3.1	7.2	1.0	2.7	1.0
Commuting to job workplace: Walk	2.8	3.1	5.8	-1.4	-1.3	-2.4
Mouth/teeth dental problems	2.7	4.2	7.4	-0.7	-2.7	-2.2
Qualifications: A levels/AS levels or equivalent	2.7	6.0	8.5	-2.9	-2.3	-2.1
Diverticular disease/diverticulitis (self-reported)	2.6	3.1	6.2	-1.5	-2.5	-0.9
Number of full brothers	2.6	3.3	6.8	2.6	1.4	1.0
Friendships satisfaction	2.6	3.2	6.1	-2.5	-1.0	-1.6
Medication for hormone replacement therapy	2.5	2.8	5.5	2.4	0.6	1.6
Pain all over the body in last month	2.5	2.7	4.4	-0.2	1.9	2.1
Mouth/teeth dental problems: Dentures	2.5	4.2	6.2	0.9	2.5	2.4
Ever had prostate specific antigen (PSA) test	2.5	2.9	3.6	-1.8	-1.9	-1.4
Alcohol drinker status: Previous	2.5	2.9	6.5	1.1	2.5	1.0
Type 2 Diabetes (T2D) (2012)	2.4	2.8	6.8	2.6	0.7	1.0
Length of working week for main job	2.4	2.6	6.0	2.4	1.3	0.5
Age at last live birth	2.4	3.4	4.4	-2.0	-1.4	-2.1
Hearing aid user	2.4	2.8	4.0	-1.1	2.0	1.8
Reaction Time	2.3	4.5	6.7	-2.6	-2.5	-0.6
Hayfever/allergic rhinitis (self-reported)	2.3	3.0	7.5	1.1	2.7	0.3
Age at first live birth	2.3	4.1	6.0	-2.4	-1.5	-2.0
Mother’s age at death	2.2	2.8	7.7	-0.9	-2.8	-0.1
Average weekly beer plus cider intake	2.2	3.1	7.8	2.8	1.1	0.7
Qualifications: None of the above	2.1	4.4	8.5	2.9	0.9	2.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.1	2.5	4.5	2.1	0.7	1.6
Pulse rate, automated reading	2.0	6.5	10.2	2.1	3.2	2.2
Neuroticism (2016)	1.9	2.7	3.4	-1.8	-1.2	-1.9
Depression (self-reported)	1.9	2.2	3.8	1.9	1.6	0.7
Hand grip strength (right)	1.8	4.9	6.5	-2.0	-2.0	-2.6
Leg pain on walking	1.8	2.2	3.5	1.0	1.9	1.5
Average weekly red wine intake	1.8	2.7	4.4	-1.6	-1.1	-2.1
Age started oral contraceptive pill	1.8	2.3	5.2	-2.3	-1.1	0.7
HbA1C	1.7	1.8	3.2	1.2	1.8	0.9
Maternal smoking around birth	1.7	2.5	4.1	1.7	2.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	4.4	-1.7	-0.8	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.7	1.8	4.3	2.1	1.1	0.3
Tinnitus: Yes, now most or all of the time	1.7	2.0	5.5	0.3	2.3	0.7
Coronary Artery Disease (CAD)	1.6	1.9	3.8	1.9	1.3	0.5
Schizophrenia (2014)	1.6	3.5	5.2	-0.9	-2.3	-2.1
Medication: Metformin	1.6	2.2	3.4	1.1	1.4	1.8
Time employed in main current job	1.6	1.9	2.8	-1.6	-1.7	-0.7
Medication: Amlodipine	1.6	2.2	3.8	-1.6	-1.9	-0.5
Alcohol intake frequency.	1.6	3.7	7.4	0.6	2.7	1.8
Intelligence (Savage-Jansen 2018)	1.5	4.7	8.3	-2.3	-0.4	-2.9
Bipolar Disorder (2011)	1.5	1.4	2.5	-1.6	-1.0	-0.9
Neuroticism	1.5	3.6	5.2	-2.3	-1.4	-1.9
Hand grip strength (left)	1.5	3.9	5.6	-2.0	-1.4	-2.4
Neuroticism score	1.5	3.1	4.3	-2.1	-1.0	-2.0
Guilty feelings	1.5	2.3	4.6	-2.2	-1.0	-1.2
Diabetes (self-reported)	1.4	2.1	5.4	1.0	-0.2	2.3
Pulse rate	1.4	2.3	4.6	2.1	1.1	1.0
Medication: Ventolin 100micrograms inhaler	1.4	1.8	3.2	0.3	1.8	1.4
Comparative body size at age 10	1.4	3.9	9.4	-1.5	-3.1	0.1
Mean time to correctly identify matches	1.4	2.6	4.3	-1.9	-2.1	0.1
Illnesses of father: Heart disease	1.4	2.0	4.2	-1.3	-2.1	-0.1
Diastolic blood pressure, automated reading	1.4	4.3	7.4	1.8	1.5	2.7
Mean Putamen Volume	1.3	1.4	2.5	1.6	-1.3	0.1
Ever used hormone-replacement therapy (HRT)	1.3	1.6	2.7	1.4	0.3	1.7
Ever had hysterectomy (womb removed)	1.3	1.5	2.1	1.1	1.1	1.4
Supplements: Zinc	1.3	1.4	2.2	-0.1	-1.5	-1.4
Worry too long after embarrassment	1.3	2.1	6.3	-2.5	-0.1	-0.2
Diabetes diagnosed by doctor	1.3	2.2	5.7	0.8	0.3	2.4
Osteoporosis (self-reported)	1.3	1.6	2.6	-0.0	1.6	1.5
Medication: Lisinopril	1.3	1.7	3.9	-2.0	-0.9	-0.7
Basal cell carcinoma (self-reported)	1.3	1.5	3.5	-1.9	-1.0	0.3
Verbal and Numeric Reasoning (VNR)	1.2	2.9	4.2	-2.0	-0.7	-2.0
Tanning	1.2	14.4	23.2	-3.6	-4.8	-2.6
Systolic blood pressure, automated reading	1.2	3.4	8.4	0.8	1.0	2.9
Body fat percentage	1.2	4.6	7.3	2.7	1.9	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.5	1.9	0.8	0.5
Risk taking	1.2	1.7	3.0	1.7	1.0	-1.1
Qualifications: CSEs or equivalent	1.1	1.4	3.4	0.8	1.8	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	4.3	-0.9	-0.2	-2.1
Happiness	1.1	1.3	2.1	-1.2	-1.5	-0.5
Hair/balding pattern: Pattern 4	1.1	2.6	5.0	-0.6	-2.2	1.6
Leg fat percentage (right)	1.1	3.9	5.4	2.3	1.8	1.8
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.1	-1.3	-0.4	-1.5
Medication: Aspirin	1.1	1.5	2.0	-1.2	1.0	1.4
Ever taken oral contraceptive pill	1.1	1.3	2.1	-1.4	0.1	-1.3
Financial situation satisfaction	1.1	1.3	2.4	1.6	1.1	-0.7
Leg fat percentage (left)	1.1	3.8	5.3	2.3	1.6	1.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	3.6	1.9	0.2	-0.9
Hearing difficulty/problems: Yes	1.0	1.5	3.7	0.1	1.9	1.0
Trunk fat percentage	1.0	4.1	6.9	2.6	1.7	1.5
Townsend deprivation index at recruitment	1.0	1.3	2.3	0.9	1.5	0.9
Current tobacco smoking	1.0	1.7	3.4	1.1	1.8	-0.6
Exposure to tobacco smoke at home	1.0	1.2	2.1	1.4	0.2	-1.2
Peak expiratory flow (PEF)	1.0	2.3	4.7	-0.7	-2.2	1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.5	2.2	-1.5	-0.6	-1.4
Medication: Aspirin	1.0	1.3	1.4	-1.2	1.0	1.1
Long-standing illness, disability or infirmity	1.0	1.5	3.1	1.2	0.1	1.8
Eye problems/disorders: Cataract	1.0	1.1	1.4	1.2	1.2	0.8
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.6	1.9	0.4	-0.1
Ever depressed for a whole week	1.0	1.3	1.5	-1.2	-1.2	-0.9
Supplements: Calcium	1.0	1.1	3.1	-0.5	-1.8	-0.4
Pack years of smoking	1.0	1.5	3.2	-1.8	-1.1	-0.1
Neuroticism (Nagel 2018)	0.9	2.1	4.1	-2.0	-0.8	-1.3
Ulcerative Colitis	0.9	1.4	2.0	-1.3	1.4	-0.7
Loud music exposure frequency	0.9	0.9	2.0	0.7	1.4	0.5
Pulse wave peak to peak time	0.9	1.1	2.0	-1.4	-0.9	-0.7
Emphysema/chronic bronchitis	0.9	1.0	2.5	-0.6	-0.2	1.6
Neck or shoulder pain in last month	0.9	1.3	2.7	1.0	1.6	0.3
Smoking status: Current	0.9	1.4	2.1	1.2	1.4	-0.8
Medication: Paracetamol	0.9	1.4	2.3	0.7	1.2	1.5
Medication: Atorvastatin	0.9	1.2	1.5	1.0	1.0	1.2
Number of operations (self-reported)	0.9	1.4	1.9	0.7	1.4	1.3
Commuting to job workplace: Cycle	0.9	1.1	1.2	-1.1	-1.1	1.0
Primary Biliary Cirrhosis	0.8	1.1	3.2	-0.2	1.8	-0.2
Smoking Status	0.8	1.9	3.1	0.8	1.4	-1.8
Respiratory disease	0.8	1.8	4.8	-0.7	0.0	2.2
Taking other prescription medications	0.8	1.2	2.9	0.4	0.8	1.7
Age when periods started (menarche)	0.8	1.8	4.6	0.9	2.1	0.0
Medication: Atenolol	0.8	1.0	1.3	1.0	0.9	1.1
Had other major operations	0.8	0.9	2.1	0.8	1.4	0.0
Tense / ‘highly strung’	0.8	1.4	1.9	-1.3	0.7	-1.4
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.1	-0.6	0.5	-1.4
Blood clot in the leg (DVT)	0.8	1.0	2.1	1.4	0.1	-1.0
Medication for cholesterol	0.8	1.2	1.9	-1.4	-0.5	-1.2
Mineral and other dietary supplements	0.8	1.1	2.0	0.1	1.1	-1.4
Fractured/broken bones in last 5 years	0.8	1.0	1.4	1.1	0.6	1.2
Depressed Affect (Nagel 2018)	0.7	1.5	2.3	-1.3	-0.6	-1.5
Fasting Glucose	0.7	0.9	1.5	1.1	1.2	-0.1
Lupus	0.7	1.0	1.8	-1.3	0.2	-1.1
Relative age of first facial hair	0.7	1.4	2.0	1.2	-1.4	-1.0
Severe depression (siblings)	0.7	0.7	1.1	0.9	0.5	1.0
Pack years adult smoking proportion	0.7	1.1	2.3	-1.5	-1.0	-0.3
Fed-up feelings	0.7	1.3	3.4	-0.0	-0.7	-1.8
Relative age voice broke	0.7	1.1	1.9	1.2	-0.3	-1.4
Supplements: Glucosamine	0.7	0.9	2.6	-1.6	-0.3	-0.2
Ever unenthusiastic/disinterested for a whole week	0.7	0.9	2.1	-0.7	-0.2	-1.4
Arm fat percentage (right)	0.7	2.8	5.5	2.3	1.4	0.9
Hair/balding pattern: Pattern 3	0.7	1.0	2.6	-0.3	0.6	1.6
Number of children fathered	0.7	0.8	1.3	1.1	-1.1	-0.1
Ever had bowel cancer screening	0.7	0.8	1.4	-0.9	-0.5	1.2
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.2	1.5	0.8	-0.7
Medication: Gliclazide	0.7	0.8	1.7	0.8	0.3	1.3
Average weekly champagne plus white wine intake	0.7	1.0	2.8	-0.1	0.4	1.7
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.6	-0.5	-0.9	1.3
High cholesterol (Self-reported)	0.7	1.3	2.4	-1.0	0.7	1.5
Bipolar Disorder or Schizophrenia	0.6	1.4	2.0	-0.8	-1.3	-1.4
Depression (Nagel 2018)	0.6	0.8	1.9	-0.7	-1.4	-0.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.8	-0.1	-0.8	-1.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.1	-1.0	-1.1	-0.6
Body mass index (BMI)	0.6	2.4	3.2	1.8	1.1	1.7
Trunk fat mass	0.6	2.6	3.9	2.0	1.1	1.6
Medication: Ramipril	0.6	0.7	1.7	-0.6	0.4	-1.3
Trunk fat-free mass	0.6	3.3	5.2	-2.2	-2.3	0.1
Number of live births	0.6	0.8	1.4	0.9	0.5	1.2
Trunk predicted mass	0.6	3.4	5.3	-2.2	-2.3	0.1
Medication: Paracetamol	0.6	1.0	1.6	0.8	1.3	0.9
Eye problems/disorders: None of the above	0.6	0.7	1.5	0.1	-1.2	0.8
Mouth/teeth dental problems: Loose teeth	0.6	0.8	1.4	0.2	1.2	0.9
Whole body fat mass	0.6	2.6	3.8	2.0	1.0	1.7
Leg fat mass (right)	0.6	2.2	2.9	1.5	1.3	1.7
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	1.1	0.7	1.0	0.8
Arm fat percentage (left)	0.6	2.2	3.8	2.0	1.4	0.9
Alcohol drinker status: Never	0.6	0.7	1.2	-0.9	1.1	0.1
Bipolar Disorder (2018)	0.5	0.7	1.3	-1.1	-0.8	-0.5
Schizophrenia (2018)	0.5	1.0	2.1	0.1	-1.0	-1.4
Worry (Nagel 2018)	0.5	1.1	1.8	-1.3	-0.2	-1.3
Lung FVC	0.5	2.8	6.8	-1.2	-0.3	2.6
Number of treatments/medications taken	0.5	0.8	1.8	0.1	0.8	1.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	0.6	0.8	-0.8	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.3	-0.7	0.8	-1.5
Medication: Levothyroxine sodium	0.5	0.8	1.7	1.3	0.4	0.7
Waist circumference	0.5	2.0	2.6	1.6	1.4	1.2
Number of incorrect matches in round	0.5	0.9	1.6	-0.7	-1.3	0.8
Forced vital capacity (FVC)	0.5	1.8	4.0	-1.0	-0.5	2.0
Hip circumference	0.5	2.0	3.0	1.6	0.7	1.7
Lung cancer (father)	0.5	0.5	1.0	0.6	1.0	-0.6
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	1.1	0.5	0.5
Standing height	0.5	5.3	7.8	-2.8	-2.8	-0.7
Breastfed as a baby	0.5	0.6	1.5	-0.1	-0.5	-1.2
Gout (self-reported)	0.5	0.7	1.7	-0.1	-1.3	-0.5
Medication: Blood pressure	0.5	0.8	1.1	-1.1	-0.9	-0.7
Suffer from ‘nerves’	0.5	0.8	1.7	0.8	1.3	0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.3	-1.2	-0.7	0.2
Illnesses of siblings: Diabetes	0.5	0.6	1.8	-1.3	-0.3	-0.2
Illnesses of father: None of the above (group 1)	0.5	0.7	1.8	0.4	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.2	3.4	-0.2	0.0	1.9
Irritability	0.5	0.8	2.3	-0.2	-0.1	-1.5
Unable to work because of sickness or disability	0.5	0.7	2.0	0.0	1.4	0.3
Leg fat mass (left)	0.5	1.8	2.8	1.4	0.9	1.7
Ulcerative Colitis (UC)	0.4	0.8	2.0	-0.6	1.4	-0.1
HDL Cholesterol	0.4	0.7	1.4	-1.2	-0.3	-0.7
Systolic Blood Pressure	0.4	1.8	2.2	1.0	1.5	1.4
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.6	0.5	-0.5	1.3
Average weekly spirits intake	0.4	0.4	0.6	-0.7	-0.5	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.2	-1.0	0.5
Alcohol usually taken with meals	0.4	0.6	1.0	-0.5	-1.0	0.8
Nervous feelings	0.4	0.8	2.3	0.2	1.5	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.1	0.7	-0.3	-1.1
Hearing difficulty/problems with background noise	0.4	0.7	1.3	0.8	1.1	0.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.4	-0.2	0.3	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.0	-0.9	-0.3	1.4
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	3.8	-0.6	-0.3	2.0
Noisy workplace	0.4	0.5	1.1	-0.6	1.1	0.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	-0.6	-0.9	0.2
Medication for pain relief, constipation, heartburn	0.4	0.8	1.0	0.7	-0.8	-1.0
Medication: Allopurinol	0.4	0.6	1.3	-0.7	-1.1	-0.1
Number of full sisters	0.4	0.5	0.8	0.9	-0.7	-0.6
Hypertension (Self-reported)	0.4	1.1	1.9	-1.4	-0.8	-0.8
Miserableness	0.4	0.7	1.8	0.0	-0.5	-1.3
Cholesterol lowering medication	0.4	0.6	1.8	0.0	-0.4	1.3
Schizophrenia vs Biploar Disorder	0.3	0.4	1.1	-0.1	-0.2	-1.0
Alzheimer’s Disease (in mother)	0.3	0.3	0.6	0.8	0.1	0.6
Alzheimer’s Disease (in father)	0.3	0.4	1.0	0.1	0.2	1.0
Irritable Bowel Disease (IBD)	0.3	0.7	1.1	-0.6	0.8	-1.0
Breast Cancer	0.3	0.8	1.3	1.1	-1.1	0.2
Body Mass Index (BMI) (2010)	0.3	0.4	1.1	0.0	-0.2	-1.0
Height	0.3	5.6	10.0	-2.5	-3.2	-0.8
Allergy or Eczema	0.3	0.8	1.9	-1.4	0.7	-0.4
Hypothyroidism (self reported)	0.3	0.6	1.1	-0.2	-1.1	-0.8
Chronotype (morning person)	0.3	0.8	1.8	0.4	-1.4	0.6
Vitamin and mineral supplements	0.3	0.4	0.9	-0.4	0.3	-0.9
Serious illness, injury or assault to yourself	0.3	0.4	0.5	-0.6	-0.7	-0.5
Had menopause	0.3	0.4	1.0	0.2	-0.0	1.0
Heart attack	0.3	0.3	0.7	-0.5	-0.8	-0.1
Medication: Simvastatin	0.3	0.5	1.3	0.4	-0.3	1.1
Illnesses of siblings	0.3	0.5	1.3	0.4	1.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.4	0.9	-1.0	-0.6	-0.3
Arm fat mass (right)	0.3	1.4	2.5	1.6	0.7	1.1
Headache pain in last month	0.3	0.6	0.8	-0.8	-0.9	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	1.1	0.6	-0.3
Glaucoma (self-reported)	0.3	0.4	0.4	-0.6	-0.6	-0.6
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	-0.6	-1.0	-0.6
Forced vital capacity (FVC), Best measure	0.3	1.0	1.6	-1.1	-0.5	1.3
Arm fat-free mass (right)	0.3	1.3	1.6	-1.2	-1.0	1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.3	0.6	0.8	0.0	-0.7
Medication: Ibuprofen	0.3	0.4	1.0	-1.0	-0.2	-0.2
Comparative height size at age 10	0.3	1.8	2.2	-1.4	-1.5	1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	-0.2	-0.0	-1.3
Whole body fat-free mass	0.3	1.6	2.8	-1.4	-1.7	0.3
Breast cancer (self-reported)	0.3	0.3	0.4	-0.4	0.6	0.6
Osteoarthritis (self-reported)	0.3	0.4	0.8	0.3	0.6	0.9
Whole body water mass	0.3	1.6	2.7	-1.4	-1.6	0.3
Arm fat mass (left)	0.3	1.1	1.8	1.3	0.5	1.1
Number of self-reported non-cancer illnesses	0.3	0.5	1.3	0.1	0.4	1.2
Wears glasses or contact lenses	0.3	0.4	0.9	0.9	-0.1	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	-0.9	-0.5	-0.3
Medication: Blood pressure	0.3	0.6	1.1	-1.1	-0.4	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.6	-0.5	0.8	-0.3
Arm predicted mass (left)	0.3	1.6	2.6	-1.1	-1.6	1.0
Alzheimer’s Disease (including proxy)	0.2	0.3	0.6	0.8	-0.1	0.4
Major Depression (MDD)	0.2	0.2	0.5	-0.7	0.3	-0.1
Prostate Cancer	0.2	0.3	0.7	-0.9	0.0	-0.2
Crohns Disease (2012)	0.2	0.3	0.6	-0.4	0.1	-0.8
LDL Cholesterol	0.2	0.3	0.6	-0.7	0.1	-0.5
Rheumatoid Arthritis	0.2	0.3	0.8	0.0	-0.9	0.1
Triglycerides	0.2	0.4	1.2	0.1	-1.1	-0.1
Blood Red Count	0.2	1.8	4.9	-0.6	-2.2	-0.2
Heel T-Score	0.2	1.4	2.3	1.5	-0.6	1.2
Cardiovascular Disease	0.2	0.6	1.4	-0.5	-0.4	-1.2
Angina	0.2	0.2	0.6	0.2	0.1	0.8
Diabetes (father)	0.2	0.3	0.8	-0.9	-0.1	0.0
Impedance of leg (right)	0.2	0.8	2.1	0.4	1.5	0.4
Average weekly fortified wine intake	0.2	0.3	0.6	-0.4	-0.8	0.1
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.5	0.5	0.2
Financial difficulties in last 2 years	0.2	0.3	0.7	0.8	0.3	-0.5
Allergy	0.2	0.5	1.1	0.2	-1.1	0.6
Impedance of arm (right)	0.2	0.8	1.5	0.8	0.6	-1.2
Alcohol intake versus 10 years previously	0.2	0.3	0.5	0.7	-0.3	-0.6
Father’s age at death	0.2	0.3	0.4	-0.4	-0.6	-0.6
Falls in the last year	0.2	0.3	0.7	-0.9	0.0	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.8	-0.3	0.3
Asthma	0.2	0.5	1.3	0.1	0.3	1.1
Medication: Cholesterol lowering	0.2	0.3	0.7	0.4	0.4	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.8	1.6	-0.8	-0.3	1.2
Impedance of arm (left)	0.2	0.8	1.6	0.3	0.8	-1.2
Birth weight of first child	0.2	0.3	0.4	0.7	0.5	0.5
Exposure to tobacco smoke outside home	0.2	0.3	0.3	0.6	0.5	0.5
Angina (self-reported)	0.2	0.3	0.9	0.2	-0.2	0.9
Migraine (self-reported)	0.2	0.2	0.5	-0.7	-0.5	0.1
Medication: Omeprazole	0.2	0.3	0.4	-0.6	0.6	0.1
Arm predicted mass (right)	0.2	1.1	1.4	-1.1	-0.9	1.2
Chest pain or discomfort	0.2	0.3	0.9	-0.2	-0.2	1.0
Knee pain experienced in last month	0.2	0.2	0.5	0.2	0.4	0.7
Mood swings	0.2	0.3	0.4	0.5	0.6	-0.6
Back pain experienced in last month	0.2	0.2	0.5	0.4	-0.2	-0.7
Asthma (self-reported)	0.2	0.4	1.1	-0.2	0.1	1.1
Illnesses of father: High blood pressure	0.2	0.2	0.5	-0.7	-0.4	-0.3
Basal metabolic rate	0.2	0.9	1.7	-1.0	-1.3	0.4
Arm fat-free mass (left)	0.2	1.2	1.7	-0.8	-1.3	1.1
Heart disease (siblings)	0.2	0.2	0.6	-0.8	-0.2	-0.2
Crohns Disease (2017)	0.1	0.2	0.3	0.4	0.5	-0.5
Ovarian Cancer	0.1	0.2	0.3	-0.2	0.5	0.4
Blood Eosinophil Count	0.1	0.5	1.5	-0.1	-0.2	-1.2
Blood Platelet Count	0.1	1.2	2.8	0.9	1.7	0.1
Blood White Count	0.1	0.7	1.0	-0.8	1.0	0.5
Waist Hip Ratio (WHR)	0.1	0.6	1.2	0.1	0.8	-1.1
Hair Pigment	0.1	2.6	4.6	2.1	1.7	0.6
Leg fat-free mass (left)	0.1	0.4	0.8	-0.6	-0.9	0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.4	-0.4	0.7
High blood pressure	0.1	0.3	0.9	-0.9	-0.1	-0.1
Multivitamins +/- minerals	0.1	0.1	0.3	-0.4	-0.5	0.1
Sitting height	0.1	1.0	1.5	-1.2	-1.2	0.4
Chronic bronchitis/emphysema (father)	0.1	0.1	0.3	0.1	0.2	0.6
High blood pressure (mother)	0.1	0.1	0.2	-0.5	0.0	-0.4
Impedance of leg (left)	0.1	0.4	1.0	0.3	1.0	0.5
Leg predicted mass (left)	0.1	0.4	0.8	-0.6	-0.9	0.0
Past tobacco smoking	0.1	0.2	0.4	-0.4	0.4	0.6
Weight	0.1	0.6	1.5	0.6	-0.1	1.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.4	0.0	0.4
Illnesses of mother	0.1	0.1	0.3	-0.1	0.3	-0.5
Pulse wave reflection index	0.1	0.1	0.3	0.1	-0.5	-0.4
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.3	-0.6	0.1	0.2
Birth weight	0.1	0.2	0.6	-0.1	-0.8	0.1
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.2	0.2	0.5
Heart disease (mother)	0.1	0.1	0.3	0.5	0.4	0.2
Overall health rating	0.1	0.2	0.4	0.6	0.4	-0.3
Had major operations	0.1	0.1	0.2	-0.1	0.4	0.5
Smoking status: Previous	0.1	0.2	0.4	0.1	-0.5	-0.6
Leg fat-free mass (right)	0.1	0.5	1.3	-0.6	-1.1	0.0
Leg predicted mass (right)	0.1	0.6	1.2	-0.7	-1.1	0.0
Ever smoked	0.1	0.2	0.5	0.5	0.1	-0.7
Myopia	0.1	0.2	0.4	-0.2	-0.5	-0.6
Pain experienced in last month	0.1	0.2	0.4	-0.0	-0.6	-0.5
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.2	-0.4	-0.4	0.2
Impedance of whole body	0.1	0.6	1.4	0.6	1.2	-0.3
Age at First Birth	0.0	0.0	0.1	-0.2	0.1	0.3
BMI	0.0	0.1	0.3	-0.5	-0.0	0.3
Lung FEV1/FVC ratio	0.0	0.1	0.3	-0.2	-0.6	-0.2
Sensitivity / hurt feelings	0.0	0.1	0.2	-0.0	0.5	-0.0
Other serious medical condition/disability diagnosed by doctor	0.0	0.1	0.1	-0.0	0.4	-0.1
High blood pressure (siblings)	0.0	0.1	0.2	-0.0	-0.5	-0.0
Supplements: Vitamin C	0.0	0.0	0.1	0.3	-0.0	0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.2	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.0	0.1	0.3	0.5	-0.3	-0.1

Hub : Genes

PART1

Models

Trait associations