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chr10:103,527,782-105,647,095

Best TWAS P=1.7e-13 · Best GWAS P=1.01e-11 conditioned to 0.398

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Adipose Subcutaneous	WBP1L	0.05	0.00	enet	8	0.00	5.3e-01	6.8	-7.4	1.7e-13	-0.87	0.05	0.63	TRUE
14	GTEx	Breast Mammary Tissue (Female)	TMEM180	0.18	0.06	lasso	4	0.07	4.5e-03	6.8	7.0	2.0e-12	0.79	0.04	0.85	FALSE
21	GTEx	Esophagus Muscularis	SUFU	0.07	0.04	enet	18	0.03	5.2e-03	6.3	7.0	2.8e-12	0.78	0.05	0.91	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SUFU	0.03	0.02	blup	90	0.02	1.5e-02	6.2	7.0	3.6e-12	0.91	0.04	0.67	FALSE
40	YFS	Blood	TRIM8	0.04	0.04	lasso	6	0.05	1.2e-15	6.8	-6.9	6.2e-12	-0.91	0.02	0.98	FALSE
6	GTEx	Adrenal Gland	TMEM180	0.19	0.15	enet	12	0.09	3.5e-04	6.4	6.8	1.2e-11	0.82	0.09	0.88	FALSE
10	GTEx	Brain Cerebellum	TMEM180	0.25	0.29	enet	11	0.26	3.5e-08	6.4	6.7	3.0e-11	0.90	0.06	0.94	FALSE
39	NTR	Blood	TRIM8	0.02	0.01	enet	11	0.01	2.1e-03	6.3	-6.6	3.1e-11	-0.80	0.04	0.95	FALSE
12	GTEx	Breast Mammary Tissue	TMEM180	0.17	0.16	enet	9	0.17	3.6e-09	6.3	6.6	3.4e-11	0.94	0.04	0.96	FALSE
38	NTR	Blood	ACTR1A	0.03	0.03	enet	19	0.03	1.4e-09	6.3	-6.6	3.8e-11	-0.84	0.19	0.81	FALSE
17	GTEx	Colon Sigmoid	TMEM180	0.32	0.41	lasso	3	0.38	1.5e-14	6.4	6.6	4.3e-11	0.89	0.12	0.88	FALSE
2	CommonMind	Brain Pre-frontal Cortex	ARL3	0.03	0.03	lasso	6	0.03	1.8e-04	5.7	-6.5	6.8e-11	-0.92	0.02	0.97	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	C10orf95	0.02	0.03	lasso	2	0.02	4.7e-03	6.4	6.5	9.0e-11	0.87	0.01	0.92	FALSE
9	GTEx	Brain Cerebellar Hemisphere	TMEM180	0.23	0.23	lasso	10	0.10	1.3e-03	6.3	6.4	1.2e-10	0.93	0.03	0.96	FALSE
43	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ACTR1A	0.02	0.02	lasso	5	0.02	4.6e-03	6.3	-6.4	1.3e-10	-0.89	0.02	0.80	FALSE
22	GTEx	Esophagus Muscularis	TMEM180	0.23	0.22	enet	19	0.19	1.6e-11	6.3	6.4	1.7e-10	0.93	0.07	0.93	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMEM180	0.16	0.27	lasso	4	0.27	4.3e-28	6.3	6.4	1.7e-10	0.74	0.02	0.98	FALSE
7	GTEx	Artery Coronary	TMEM180	0.14	0.05	enet	13	0.04	2.4e-02	6.4	6.2	4.5e-10	0.84	0.08	0.69	FALSE
27	GTEx	Nerve Tibial	TMEM180	0.32	0.30	enet	16	0.32	2.0e-23	6.4	6.2	4.9e-10	0.89	0.18	0.82	FALSE
11	GTEx	Brain Hypothalamus	TMEM180	0.21	0.20	lasso	5	0.12	8.5e-04	6.3	6.2	5.1e-10	0.92	0.04	0.86	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	SUFU	0.03	0.03	lasso	1	0.03	2.0e-04	6.2	6.2	5.5e-10	0.92	0.11	0.86	FALSE
15	GTEx	Cells EBV-transformed lymphocytes	RP11-18I14.11	0.17	0.08	lasso	8	0.09	8.7e-04	6.2	-6.2	6.2e-10	-0.75	0.13	0.45	FALSE
16	GTEx	Cells Transformed fibroblasts	TMEM180	0.05	0.04	lasso	2	0.01	3.3e-02	6.2	-6.2	6.6e-10	-0.77	0.19	0.41	FALSE
18	GTEx	Colon Transverse	TMEM180	0.16	0.15	enet	11	0.13	1.2e-06	6.4	6.2	7.3e-10	0.88	0.16	0.84	FALSE
30	GTEx	Skin Sun Exposed Lower leg	SUFU	0.06	0.05	enet	12	0.06	8.4e-06	6.2	-6.1	8.5e-10	-0.77	0.35	0.64	FALSE
37	METSIM	Adipose	TMEM180	0.28	0.25	enet	33	0.26	2.5e-39	6.3	6.0	2.2e-09	0.86	0.22	0.78	FALSE
36	GTEx	Uterus	TMEM180	0.22	0.00	enet	23	0.00	2.6e-01	6.4	5.9	3.2e-09	0.64	0.04	0.44	FALSE
24	GTEx	Heart Left Ventricle	TMEM180	0.19	0.17	enet	14	0.17	3.7e-09	6.4	5.9	3.3e-09	0.90	0.06	0.94	FALSE
44	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMEM180	0.03	0.03	blup	52	0.04	3.9e-05	6.1	-5.9	3.5e-09	-0.80	0.04	0.95	FALSE
31	GTEx	Spleen	TMEM180	0.16	0.21	lasso	3	0.05	2.6e-02	6.3	5.9	4.3e-09	0.90	0.05	0.79	FALSE
8	GTEx	Artery Tibial	TMEM180	0.07	0.05	enet	14	0.03	3.8e-03	6.4	5.9	4.5e-09	0.85	0.11	0.88	FALSE
20	GTEx	Esophagus Mucosa	SUFU	0.08	0.02	enet	18	0.01	4.2e-02	5.8	5.9	4.5e-09	0.70	0.07	0.91	FALSE
32	GTEx	Stomach	TMEM180	0.33	0.22	lasso	8	0.21	2.2e-10	6.4	5.8	5.2e-09	0.85	0.14	0.86	FALSE
29	GTEx	Pituitary	TMEM180	0.36	0.23	enet	12	0.20	1.1e-05	6.4	5.8	6.1e-09	0.84	0.07	0.89	FALSE
25	GTEx	Liver	TMEM180	0.28	0.17	enet	36	0.17	1.7e-05	6.2	5.8	6.8e-09	0.66	0.17	0.79	FALSE
26	GTEx	Lung	TMEM180	0.12	0.11	lasso	4	0.13	5.1e-10	6.4	5.6	1.8e-08	0.88	0.04	0.96	FALSE
13	GTEx	Breast Mammary Tissue (Male)	TMEM180	0.26	0.15	lasso	17	0.17	1.0e-04	6.4	5.6	2.2e-08	0.89	0.03	0.90	FALSE
34	GTEx	Thyroid	C10orf95	0.10	0.02	enet	28	0.02	6.6e-03	6.4	5.6	2.6e-08	0.67	0.07	0.70	FALSE
23	GTEx	Heart Atrial Appendage	TMEM180	0.42	0.21	enet	35	0.27	2.1e-12	6.4	5.5	2.9e-08	0.67	0.16	0.83	FALSE
35	GTEx	Thyroid	TMEM180	0.31	0.38	enet	20	0.42	8.1e-35	6.4	5.5	3.2e-08	0.87	0.16	0.84	FALSE
33	GTEx	Testis	TMEM180	0.19	0.05	enet	24	0.12	7.9e-06	6.4	5.5	3.9e-08	0.72	0.05	0.94	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	TMEM180	0.22	0.23	enet	11	0.27	3.0e-10	6.3	5.5	4.5e-08	0.86	0.09	0.91	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	TMEM180	0.04	0.02	enet	9	0.05	4.2e-04	-1.6	-5.4	6.0e-08	-0.70	0.02	0.73	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ACTR1A	0.03	0.01	blup	347	0.01	5.6e-02	-4.8	-5.4	6.6e-08	-0.62	0.14	0.28	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	C10orf26	0.03	0.02	enet	5	0.02	1.6e-04	4.9	5.3	1.2e-07	0.62	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	TMEM180	0.24	0.16	enet	11	0.18	2.2e-14	6.3	5.2	1.6e-07	0.79	0.23	0.77	FALSE
28	GTEx	Pituitary	NT5C2	0.19	-0.01	lasso	10	0.01	1.8e-01	6.8	5.1	2.9e-07	0.82	0.02	0.68	FALSE
5	GTEx	Adipose Visceral Omentum	WBP1L	0.08	0.00	enet	13	0.01	8.1e-02	-5.0	-5.1	3.1e-07	-0.65	0.07	0.51	FALSE