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chr19:9,982,334-12,196,190

Best TWAS P=1.56e-15 · Best GWAS P=1.39e-42 conditioned to 5.02e-07

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPC24	0.06	0.00	enet	15	0.01	1.4e-02	-10.6	8.0	1.6e-15	-0.35	0.00	0.55	TRUE
8	NTR	Blood	SMARCA4	0.07	0.06	lasso	11	0.06	9.0e-18	-6.9	6.9	6.8e-12	-0.38	1.00	0.00	TRUE
6	GTEx	Esophagus Muscularis	SMARCA4	0.16	0.00	lasso	6	0.03	7.2e-03	-8.3	6.8	1.2e-11	-0.39	0.17	0.08	TRUE
10	YFS	Blood	SMARCA4	0.02	0.01	enet	3	0.00	9.2e-03	-4.7	6.6	4.3e-11	-0.39	0.15	0.07	TRUE
9	ROSMAP	Brain Pre-frontal Cortex	C19orf80	0.08	0.04	enet	17	0.05	3.1e-07	2.0	6.5	7.3e-11	-0.41	0.65	0.33	TRUE
1	CommonMind	Brain Pre-frontal Cortex	CDKN2D	0.04	0.01	blup	360	0.01	3.1e-02	-3.1	5.8	8.1e-09	-0.26	0.46	0.03	TRUE
3	GTEx	Artery Aorta	RGL3	0.15	0.00	enet	23	0.00	2.8e-01	2.3	5.7	1.1e-08	-0.18	0.06	0.04	TRUE
12	The Cancer Genome Atlas	Brain Lower Grade Glioma	KANK2	0.28	0.26	lasso	3	0.26	4.6e-29	5.6	5.6	2.3e-08	-0.02	0.88	0.12	TRUE
13	The Cancer Genome Atlas	Prostate Adenocarcinoma	KANK2	0.09	0.04	blup	76	0.06	9.5e-07	5.6	5.2	2.1e-07	-0.13	0.05	0.90	TRUE
2	GTEx	Adipose Subcutaneous	EPOR	0.11	0.04	lasso	7	0.04	3.8e-04	-8.3	-7.9	2.1e-15	0.48	0.52	0.38	FALSE
5	GTEx	Esophagus Mucosa	SMARCA4	0.18	0.03	enet	15	0.09	8.2e-07	-4.8	6.6	4.2e-11	-0.36	0.95	0.00	FALSE
11	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C19orf52	0.04	0.04	blup	27	0.03	1.7e-04	-5.8	6.0	1.9e-09	-0.37	0.00	1.00	FALSE
15	The Cancer Genome Atlas	Thyroid Carcinoma	C19orf52	0.05	0.06	lasso	4	0.06	2.5e-06	-5.2	5.8	8.9e-09	-0.36	0.01	0.99	FALSE
4	GTEx	Cells Transformed fibroblasts	CARM1	0.11	0.01	lasso	4	0.00	6.9e-01	-5.1	-5.2	1.8e-07	0.35	0.29	0.04	FALSE
7	GTEx	Skin Sun Exposed Lower leg	YIPF2	0.05	0.05	lasso	2	0.04	1.6e-04	-5.1	5.2	2.4e-07	-0.33	0.53	0.29	FALSE