TWAS hub - CDKN2D

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0360	0.0170	9.4e-03	0.005	0.008	0.007	0.007	0.001	6.9e-02	3.1e-02	4.0e-02	3.7e-02	2.2e-01
2	GTEx	Adipose Subcutaneous	0.2110	0.0490	2.8e-07	0.123	NA	0.047	NA	0.087	3.3e-10	NA	1.0e-04	NA	1.2e-07
3	GTEx	Artery Tibial	0.1546	0.0503	3.1e-04	-0.003	NA	0.001	NA	0.002	8.5e-01	NA	2.8e-01	NA	2.1e-01
4	GTEx	Muscle Skeletal	0.1168	0.0366	6.2e-05	0.090	NA	0.083	NA	0.080	3.6e-09	NA	1.5e-08	NA	3.0e-08
5	GTEx	Testis	0.4560	0.0690	3.8e-12	0.342	NA	0.360	NA	0.369	6.7e-16	NA	7.2e-17	NA	2.5e-17
6	ROSMAP	Brain Pre-frontal Cortex	0.1361	0.0346	5.8e-08	0.061	0.082	0.095	0.088	0.100	2.4e-08	9.8e-11	3.0e-12	2.3e-11	8.8e-13
7	YFS	Blood	0.1600	0.0304	0.0e+00	0.085	0.079	0.113	0.102	0.114	2.8e-26	1.3e-24	8.3e-35	1.0e-31	3.5e-35
8	TCGA	Prostate Adenocarcinoma	0.0293	0.0177	2.2e-03	0.018	0.011	-0.001	NA	0.003	5.1e-03	2.1e-02	5.0e-01	NA	1.4e-01
9	TCGA	Thyroid Carcinoma	0.0670	0.0420	6.2e-03	0.005	0.005	0.021	NA	0.013	9.0e-02	1.1e-01	3.4e-03	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Cholesterol lowering medication	6.4	9.4	33.2	5.8	3.1	0.9	3.0	3.3	3.3	0.2	3.2	0.2
LDL Cholesterol	6.2	9.8	54.6	7.4	1.8	-1.2	1.5	2.7	2.2	-1.5	3.2	1.5
Primary Biliary Cirrhosis	4.3	6.2	16.8	4.1	2.5	0.2	2.3	2.6	1.8	1.4	2.4	3.1
Medication: Atorvastatin	4.3	5.4	17.2	4.2	1.5	0.5	1.9	2.3	3.4	-1.0	1.9	1.9
Medication: Omeprazole (e.g. Zanprol)	4.1	5.0	11.9	-0.8	-2.3	-1.1	-1.9	-2.6	-1.4	-2.5	-2.7	-3.5
Medication: Gliclazide	3.7	4.2	10.0	1.7	3.2	1.1	2.9	2.5	1.9	-0.1	2.2	0.9
Rheumatoid Arthritis	3.6	5.0	12.6	-0.2	2.2	-3.5	2.2	2.6	-0.5	1.3	3.0	2.2
Blood White Count	3.5	26.2	86.5	-2.9	-4.3	1.3	-3.8	-4.6	0.1	-9.3	-5.2	-7.6
Had other major operations	3.5	4.3	7.0	0.9	2.6	1.6	2.5	2.6	2.2	1.0	2.3	2.0
Ever highly irritable/argumentative for 2 days	3.3	4.0	10.8	1.8	1.9	2.6	2.0	1.8	3.3	-0.7	1.0	1.6
High cholesterol (Self-reported)	3.3	5.9	36.6	6.0	0.9	-0.8	1.2	1.5	2.4	-1.6	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	3.2	4.1	6.3	2.3	2.0	2.0	2.1	2.5	1.6	1.1	2.5	1.9
Ever taken oral contraceptive pill	3.2	3.5	7.5	2.7	1.9	0.7	1.6	2.1	2.7	-0.5	2.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	3.0	9.6	24.3	-0.3	4.7	0.5	4.9	4.0	0.8	0.9	4.4	1.5
Crohns Disease (2017)	2.9	6.4	39.3	-1.4	-1.5	0.3	-0.7	-2.2	-0.6	-6.3	-2.6	-1.3
Average weekly fortified wine intake	2.9	3.4	6.7	-1.2	-2.4	-1.4	-2.6	-2.3	-1.0	0.1	-2.1	-2.0
Crohns Disease (2012)	2.6	4.1	8.0	-1.7	-1.7	0.1	-1.6	-2.6	-1.2	-2.8	-2.7	-2.3
Forced expiratory volume in 1-second (FEV1)	2.5	8.4	20.8	-0.1	4.4	0.3	4.6	3.8	1.2	0.5	3.9	2.0
Knee pain experienced in last month	2.4	3.7	9.5	-0.7	3.1	0.5	2.4	2.5	-0.0	1.4	2.9	0.3
Bipolar Disorder (2018)	2.3	3.7	8.8	1.1	-2.8	0.1	-2.1	-2.6	-0.3	-2.0	-3.0	-0.2
Allergy or Eczema	2.3	6.1	11.5	-3.1	-2.6	-3.4	-3.3	-1.9	-3.0	0.4	-1.2	1.3
Neck or shoulder pain in last month	2.3	3.2	7.4	-2.5	-1.1	-1.8	-1.4	-1.5	-1.5	-1.4	-1.5	-2.7
Heart disease (siblings)	2.3	2.8	9.3	3.1	0.9	1.7	1.2	1.0	1.5	-2.6	0.7	0.0
Hayfever, allergic rhinitis or eczema	2.2	4.8	11.9	-2.8	-1.8	-3.5	-2.6	-1.1	-2.8	1.2	-0.4	1.6
Peak expiratory flow (PEF)	2.2	5.2	11.8	-0.1	3.2	-0.9	3.4	3.1	0.9	1.1	3.4	0.6
Ever had prostate specific antigen (PSA) test	2.2	2.5	10.4	-1.3	-1.5	0.0	-1.7	-1.5	-0.7	-3.2	-1.4	-0.8
Medication: Co-codamol	2.1	2.5	6.0	2.1	1.5	0.6	1.5	1.2	2.4	-2.1	0.7	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.1	4.3	9.0	0.5	3.0	1.3	3.0	2.7	1.9	0.6	2.6	1.1
Hearing aid user	2.1	2.4	5.7	1.0	2.4	0.4	1.8	2.0	2.0	-0.3	1.8	0.5
Forced vital capacity (FVC), Best measure	2.0	7.4	18.9	-0.8	4.2	0.6	4.3	3.5	0.6	1.1	3.8	1.2
Current tobacco smoking	1.9	3.1	6.2	-1.8	-2.0	0.2	-2.2	-2.2	-0.4	-2.1	-2.5	-0.0
Asthma	1.9	3.8	12.9	-3.6	-0.5	-1.9	-1.7	-0.6	-2.6	1.3	0.1	-2.4
Medication: Omeprazole	1.9	2.3	8.7	0.2	-1.0	-1.0	-0.9	-1.3	-0.8	-2.2	-1.3	-3.0
Osteoarthritis (self-reported)	1.9	2.5	5.5	-1.8	1.6	-1.7	0.6	1.4	-0.4	1.3	2.0	-2.3
Hayfever/allergic rhinitis (self-reported)	1.8	2.3	5.2	-1.8	-1.0	-2.3	-1.4	-0.3	-1.7	2.0	0.2	1.6
Medication for cholesterol, blood pressure or diabetes	1.8	3.0	6.6	0.0	2.6	0.8	2.5	2.2	1.1	0.4	2.1	1.7
Medication for cholesterol	1.8	2.8	5.9	-2.4	-1.6	-1.7	-2.1	-1.6	-1.2	-0.1	-1.6	1.7
Mother’s age at death	1.8	2.2	6.1	-2.0	-0.8	-1.3	-1.8	-1.2	-2.5	1.4	-0.6	-0.3
Irritable Bowel Disease (IBD)	1.7	4.0	21.1	-1.0	-0.9	0.3	-1.0	-2.1	-1.0	-4.6	-2.4	-0.8
Respiratory disease	1.7	3.7	9.7	-3.1	-0.8	-2.2	-2.1	-0.9	-2.8	1.2	-0.2	-2.0
Forced vital capacity (FVC)	1.7	6.4	15.8	-0.5	3.8	0.6	4.0	3.3	1.2	0.4	3.3	1.7
Wheeze or whistling in the chest in last year	1.7	3.1	7.2	-2.7	-0.6	-2.3	-1.4	-1.1	-2.7	-0.6	-0.7	-2.0
Leg pain on walking	1.7	2.1	7.7	0.9	1.3	1.1	1.7	1.1	2.8	-1.7	0.5	-0.6
Asthma (self-reported)	1.7	3.4	11.6	-3.4	-0.5	-1.8	-1.6	-0.6	-2.5	1.2	0.1	-2.1
Alcohol drinker status: Never	1.7	2.1	6.9	-1.4	-0.7	-0.3	-0.9	-1.8	-1.2	-0.3	-1.9	-2.6
Age started oral contraceptive pill	1.6	2.0	5.1	-0.3	1.6	0.1	1.3	1.8	0.9	2.0	2.3	-0.2
Blood Platelet Count	1.5	17.8	44.2	-0.1	6.7	-0.2	5.9	6.0	1.5	-0.2	6.5	0.1
Taking other prescription medications	1.5	2.4	4.1	-1.7	-1.5	-1.2	-2.0	-1.6	-1.4	0.3	-1.4	-2.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.5	0.8	1.1	2.1	1.1	1.6	1.6	0.7	1.5	0.4
Allergy	1.5	3.5	9.3	2.5	1.6	3.0	2.3	1.0	2.5	-0.6	0.5	-0.7
Emphysema/chronic bronchitis	1.5	1.7	5.2	-0.1	-2.3	-0.7	-1.2	-1.6	-0.5	-1.2	-2.0	-0.1
Medication: Blood pressure	1.5	2.7	5.5	-1.1	-2.2	-0.0	-1.9	-2.0	-1.0	-0.9	-1.8	-2.4
Schizophrenia (2018)	1.4	2.8	4.5	1.5	1.7	2.0	1.9	2.1	2.0	0.2	1.8	0.7
Prostate Cancer	1.4	2.0	5.2	1.0	1.2	0.5	2.3	1.3	1.5	-1.3	1.1	1.7
Lung FEV1/FVC ratio	1.4	6.9	14.9	2.2	3.9	1.6	3.8	3.0	2.2	0.2	3.2	1.1
Pulse wave Arterial Stiffness index	1.4	1.6	6.4	-0.8	-1.1	-0.5	-1.1	-1.2	-1.3	0.3	-1.1	-2.5
Average weekly beer plus cider intake	1.4	2.1	4.4	-1.1	-2.1	0.7	-2.0	-1.8	-1.0	0.1	-2.0	-0.6
Supplements: Calcium	1.4	1.6	3.2	1.3	1.6	-0.3	1.2	1.7	1.3	0.8	1.8	0.2
Reaction Time	1.3	2.4	8.1	2.8	-0.8	0.9	-0.0	-0.8	1.4	-2.2	-1.4	1.8
Pulse wave peak to peak time	1.3	1.5	5.6	0.4	1.2	0.4	1.3	1.3	1.0	-0.5	1.2	2.4
Medication: Ibuprofen	1.3	1.5	3.0	1.0	1.1	0.8	1.6	1.4	1.7	0.1	1.3	1.2
Heart disease (mother)	1.3	1.5	7.3	1.8	0.3	-1.4	0.2	0.2	0.4	-2.7	0.5	1.0
Suffer from ‘nerves’	1.3	2.0	3.5	1.0	1.8	1.4	1.7	1.7	0.8	0.7	1.9	1.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	5.4	1.4	0.9	0.6	0.7	0.1	2.1	-2.3	-0.5	0.4
Alzheimer’s Disease (in father)	1.2	1.3	2.4	-1.0	-1.4	0.5	-1.6	-1.4	0.2	0.1	-1.5	-1.2
Neuroticism (2016)	1.2	1.7	3.1	0.6	1.7	0.3	1.5	1.7	0.6	0.8	1.6	1.8
Lung FVC	1.2	6.0	11.4	0.0	3.0	1.8	3.4	3.3	1.8	0.1	3.1	2.6
Father’s age at death	1.2	1.7	4.9	-2.1	-0.8	-0.6	-1.6	-1.0	-2.2	0.8	-0.5	-0.3
Length of working week for main job	1.2	1.3	3.0	0.8	1.5	0.3	1.7	1.4	0.9	-0.5	1.4	0.9
Gout (self-reported)	1.2	1.6	4.3	-1.9	-0.8	-1.2	-1.1	-0.9	-1.0	0.9	-0.7	-2.1
Medication: Ventolin 100micrograms inhaler	1.2	1.5	4.9	-2.2	-1.0	-0.5	-1.5	-1.1	-1.6	-0.2	-0.9	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	7.3	2.7	1.1	-0.1	0.7	1.0	1.7	0.5	0.6	0.9
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	0.1	-1.7	0.0	-1.9	-1.6	-1.2	-0.8	-1.3	-1.3
Schizophrenia vs Biploar Disorder	1.1	1.4	3.7	-0.7	1.4	-0.1	1.2	1.5	0.1	1.9	1.7	-0.0
Chronic bronchitis/emphysema (father)	1.1	1.3	3.4	-1.3	-1.2	-1.8	-1.6	-1.0	-0.3	-1.0	-0.9	0.1
Nervous feelings	1.1	2.1	3.5	1.4	1.5	1.1	1.4	1.5	1.1	1.6	1.4	1.9
Medication: Simvastatin	1.1	1.6	10.8	3.3	-1.0	-0.1	-0.7	-0.5	0.6	-0.8	-0.5	-0.7
Breastfed as a baby	1.1	1.4	2.9	1.7	0.9	1.4	1.2	0.9	1.1	0.4	0.8	1.5
Age at first live birth	1.1	2.0	3.1	-1.8	-1.7	-0.7	-1.7	-1.7	-1.7	-0.5	-1.5	-0.3
Ovarian Cancer	1.0	1.4	3.5	1.9	1.2	0.7	0.9	1.1	1.4	-0.3	0.9	1.3
Angina	1.0	1.3	4.1	-0.0	-1.2	-0.1	-1.4	-1.1	-0.8	-1.2	-1.1	-2.0
Supplements: Zinc	1.0	1.1	3.3	0.5	0.8	-1.8	0.1	0.4	0.4	1.6	0.5	-1.5
Medication: Atenolol	1.0	1.3	5.0	0.6	-1.3	-0.4	-1.4	-1.0	-0.6	-0.2	-0.9	-2.2
Heart attack	1.0	1.3	3.1	0.4	-1.5	0.1	-1.8	-1.4	-1.0	-0.8	-1.1	-1.2
Illnesses of siblings	1.0	1.4	4.3	-2.1	-0.9	-0.6	-1.1	-1.2	-0.8	1.1	-1.3	-0.8
Trunk fat-free mass	1.0	5.5	13.0	-2.3	3.6	-1.8	3.2	2.0	-1.7	-0.6	2.6	-2.0
Trunk predicted mass	1.0	5.5	12.7	-2.4	3.6	-1.8	3.2	1.9	-1.7	-0.7	2.5	-2.1
Mean time to correctly identify matches	1.0	1.9	5.1	2.0	-1.3	0.6	-0.7	-1.1	1.0	-2.3	-1.6	1.0
Illnesses of father: Heart disease	1.0	1.4	4.9	2.2	0.3	0.9	0.4	0.9	1.6	1.4	1.0	0.2
Smoking status: Current	1.0	1.5	4.4	-1.1	-1.1	0.7	-1.2	-1.4	0.1	-2.1	-1.7	0.4
Commuting to job workplace: Public transport	1.0	1.2	6.5	-2.5	-0.1	-0.1	-0.3	-0.3	-1.6	1.0	0.1	-0.4
Basal cell carcinoma (self-reported)	1.0	1.2	2.1	-0.6	-1.1	-0.8	-1.2	-1.3	-1.0	-1.4	-1.2	-1.2
Lupus	0.9	1.3	3.9	-0.6	0.2	-2.0	0.0	0.7	-0.8	1.5	1.1	1.7
Ulcerative Colitis	0.9	1.4	6.6	-0.8	-0.0	1.0	-0.9	-1.0	-1.0	-2.6	-1.0	-0.3
Serious illness, injury or assault to yourself	0.9	1.1	2.1	0.7	1.2	-0.8	1.0	1.4	1.4	-0.8	1.2	0.3
Had menopause	0.9	1.1	2.6	-0.3	-1.6	0.1	-1.4	-1.1	-1.2	1.2	-0.9	0.0
Hip circumference	0.9	3.9	10.2	-1.5	3.2	-0.7	2.8	2.0	-0.4	-0.9	2.3	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.9	1.1	0.3	1.2	0.7	0.2	2.0	-2.4	-0.5	0.0
Medication: Cholesterol lowering	0.9	1.4	7.8	2.8	-1.2	-0.4	-1.1	-0.7	0.8	-0.4	-0.8	-0.0
Birth weight of first child	0.9	1.6	3.8	-1.3	1.6	0.9	1.3	1.6	0.4	-0.8	1.9	0.2
High blood pressure (siblings)	0.9	1.4	2.2	1.4	1.1	0.4	1.2	1.5	0.6	0.9	1.5	1.4
Arm fat-free mass (right)	0.9	4.4	7.3	-2.7	2.7	-2.0	2.5	1.1	-1.9	-1.2	1.8	-2.3
Eye problems/disorders: None of the above	0.9	1.0	3.8	0.5	0.7	1.9	0.6	0.7	0.6	-0.5	0.6	1.6
Migraine (self-reported)	0.9	1.1	3.1	-1.8	-0.9	-1.3	-0.8	-1.1	-1.0	-0.3	-1.2	-0.3
Medication: Allopurinol	0.9	1.2	3.3	-1.4	-0.6	-1.1	-1.0	-0.6	-1.4	0.5	-0.1	-1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	4.0	0.4	-0.6	0.9	-0.6	-0.8	0.2	-2.0	-1.1	-1.3
Commuting to job workplace: Walk	0.9	0.9	3.3	1.8	0.6	1.4	1.0	0.5	0.7	0.4	0.3	0.8
Average weekly champagne plus white wine intake	0.9	1.3	4.9	1.3	0.3	2.2	1.0	0.4	1.9	0.2	0.2	0.6
Miserableness	0.9	1.6	3.6	1.9	1.3	0.5	0.9	1.2	1.5	0.2	0.9	1.9
Arm fat-free mass (left)	0.9	4.5	7.8	-2.6	2.7	-1.6	2.6	1.2	-1.9	-1.1	1.7	-2.8
Arm predicted mass (left)	0.9	4.7	9.2	-2.9	2.6	-1.8	2.3	1.0	-2.2	-1.0	1.6	-3.0
Schizophrenia (2014)	0.8	1.8	5.0	1.8	1.0	1.5	1.1	1.4	2.2	-0.5	1.0	0.8
Blood Eosinophil Count	0.8	5.9	20.3	-4.5	-1.1	-0.2	-1.8	-1.6	-2.3	-3.3	-1.3	-2.9
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	5.2	0.7	0.9	-2.3	0.2	0.8	-0.1	-0.3	1.1	-0.6
Supplements: Glucosamine	0.8	1.0	2.8	-1.7	-1.1	1.1	-1.0	-0.7	-1.3	0.4	-0.7	0.2
Hearing difficulty/problems with background noise	0.8	1.3	5.4	-1.1	-0.3	0.3	-0.6	-1.4	-0.4	-2.3	-1.7	0.3
Time employed in main current job	0.8	0.9	1.9	0.6	1.0	0.2	1.1	1.3	1.0	0.8	1.4	0.4
Pulse rate	0.8	1.3	2.2	1.1	0.9	1.1	1.5	1.2	0.9	1.5	1.2	0.4
Tense / ‘highly strung’	0.8	1.4	8.5	0.7	0.5	1.2	0.9	0.5	0.4	0.5	0.4	2.9
Blood clot in the leg (DVT)	0.8	1.0	5.6	2.4	0.3	0.2	0.1	0.5	1.1	-0.2	0.4	1.2
Number of full brothers	0.8	1.0	6.6	2.6	-0.1	1.4	0.3	0.0	-0.1	0.0	0.2	0.4
Number of children fathered	0.8	0.9	2.1	0.0	-1.5	-0.1	-1.2	-1.0	-0.6	-1.1	-1.0	0.8
Angina (self-reported)	0.8	1.1	3.9	0.2	-1.0	0.0	-1.1	-0.9	-0.5	-1.2	-0.9	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	2.4	-0.5	-1.6	0.9	-1.5	-1.0	-0.3	-1.0	-1.0	-0.0
Arm predicted mass (right)	0.8	3.9	6.8	-2.6	2.4	-1.9	2.2	0.9	-1.8	-1.3	1.5	-2.5
Number of full sisters	0.8	1.0	5.4	2.3	-0.1	-0.4	0.6	-0.1	0.4	-1.4	-0.3	1.0
Family relationship satisfaction	0.8	1.0	2.0	-0.3	1.1	1.4	1.1	1.1	0.6	0.3	1.1	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	5.1	-1.0	2.3	-0.1	1.8	0.9	-1.4	-0.6	1.4	-0.6
Whole body fat-free mass	0.8	4.8	10.0	-2.4	3.2	-1.7	2.9	1.6	-1.8	-1.0	2.1	-2.2
Handedness (chirality/laterality): Left-handed	0.8	1.0	2.1	0.9	-0.6	1.1	-0.6	-0.3	1.4	-1.2	-1.0	1.1
Loneliness, isolation	0.8	1.1	4.2	0.4	1.2	-0.5	0.9	1.1	1.2	-0.2	0.8	2.0
Diabetes diagnosed by doctor	0.8	1.2	3.2	-1.4	0.1	1.0	0.1	-0.7	0.7	-1.8	-0.9	-1.7
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	3.4	1.7	-0.4	-0.0	-0.3	-0.2	0.7	-0.4	-0.4	1.8
Back pain experienced in last month	0.8	1.1	2.0	0.6	1.4	1.1	1.4	1.3	1.3	0.1	1.1	0.2
Whole body water mass	0.8	4.8	10.0	-2.4	3.2	-1.8	2.9	1.6	-1.8	-0.9	2.1	-2.3
Medication: Blood pressure	0.8	1.4	7.0	1.1	0.5	1.9	0.9	0.2	0.5	0.3	0.1	-2.6
Medication: Bendroflumethiazide	0.8	1.3	4.5	-0.8	-0.9	0.6	-0.8	-1.0	-1.7	-0.4	-0.7	-2.1
Medication: Paracetamol	0.8	1.3	3.0	0.7	0.7	1.0	1.7	0.9	1.5	-1.0	0.7	1.4
Illnesses of father: High blood pressure	0.8	1.0	2.4	0.7	1.3	0.4	1.5	1.2	-0.1	0.7	1.5	0.0
Basal metabolic rate	0.8	4.5	9.0	-2.4	3.0	-1.6	2.7	1.4	-1.6	-1.1	1.9	-2.4
Coronary Artery Disease (CAD)	0.7	0.8	4.8	2.2	-0.5	0.0	-0.1	0.1	1.1	-1.0	-0.2	0.0
Mean Putamen Volume	0.7	0.9	2.2	0.5	1.2	0.3	1.5	1.1	0.3	-0.8	1.2	-0.6
Height	0.7	13.1	33.5	-5.8	3.8	-3.8	2.4	1.4	-5.3	-0.6	2.9	-3.1
Hypothyroidism (self reported)	0.7	1.6	5.6	-0.1	-1.5	-2.4	-0.1	-1.7	-0.6	-0.2	-1.7	-0.3
Type 2 Diabetes (T2D) (2018)	0.7	1.3	4.3	-0.3	0.8	2.1	1.1	0.0	1.8	-1.2	-0.3	-0.9
Sensitivity / hurt feelings	0.7	1.2	2.7	1.3	0.9	-0.5	0.7	1.1	0.2	1.4	1.3	1.6
Systolic blood pressure, automated reading	0.7	2.0	4.1	1.3	1.4	1.6	1.6	1.3	2.0	1.4	0.9	-0.5
Medication: Metformin	0.7	1.0	3.5	0.4	0.6	1.2	1.4	0.6	1.9	-0.9	0.0	0.9
Leg fat-free mass (left)	0.7	3.5	6.2	-2.3	2.4	-1.6	2.2	1.0	-1.5	-1.3	1.4	-2.5
Maternal smoking around birth	0.7	1.0	2.3	-0.3	-0.9	0.4	-1.0	-0.8	1.1	-1.5	-1.2	0.9
Relative age voice broke	0.7	1.1	1.8	0.9	1.0	1.0	1.1	1.3	1.0	0.8	1.4	0.9
Qualifications: CSEs or equivalent	0.7	1.0	2.7	0.9	1.5	-0.4	1.6	0.9	0.1	0.1	0.8	1.1
Stomach or abdominal pain in last month	0.7	0.9	1.6	-0.7	1.2	0.6	1.1	0.8	1.3	-1.1	0.5	0.9
Leg predicted mass (left)	0.7	3.6	6.3	-2.2	2.5	-1.6	2.2	1.1	-1.5	-1.3	1.5	-2.5
Financial difficulties in last 2 years	0.7	0.9	2.8	0.3	1.1	0.3	1.7	0.9	1.7	-0.5	0.3	0.4
Diabetes (self-reported)	0.7	1.1	4.2	-1.1	-0.1	0.8	0.1	-0.6	0.7	-1.4	-0.8	-2.0
Worry too long after embarrassment	0.7	1.1	8.0	0.1	0.5	-0.5	0.7	0.5	-0.0	-0.6	0.5	2.8
Medication: Aspirin	0.7	0.9	2.4	0.8	-0.8	-1.5	-0.8	-0.9	-0.2	-0.2	-0.8	-1.5
Leg fat-free mass (right)	0.7	3.7	6.9	-2.2	2.6	-1.7	2.3	1.2	-1.6	-1.2	1.6	-2.3
Mood swings	0.7	1.3	2.8	1.7	0.8	1.6	0.8	0.9	1.4	-0.3	0.6	1.4
Breast cancer (self-reported)	0.7	0.9	2.3	1.2	0.7	1.5	1.0	0.5	-0.0	-1.0	0.8	0.6
Medication: Aspirin	0.7	0.9	2.7	1.2	-0.7	-1.7	-0.7	-0.9	0.2	-0.8	-0.9	-1.0
Leg predicted mass (right)	0.7	3.8	7.0	-2.3	2.6	-1.7	2.3	1.2	-1.6	-1.2	1.7	-2.3
Tinnitus: Yes, now most or all of the time	0.7	0.9	4.2	-1.3	0.1	1.2	0.2	-0.2	-0.5	-0.1	-0.2	-2.0
Ever smoked	0.7	1.2	4.2	-0.8	-1.0	0.6	-1.0	-1.2	-0.7	-2.0	-1.2	0.5
Irritability	0.7	1.1	2.8	1.5	1.1	0.1	0.8	1.1	1.7	0.9	1.0	0.6
Fractured/broken bones in last 5 years	0.7	0.9	3.4	-0.3	1.0	-0.3	0.9	1.0	0.5	1.9	0.9	-1.1
Neuroticism (Nagel 2018)	0.6	1.4	7.7	0.5	0.6	0.7	0.6	1.1	1.1	0.6	0.9	2.8
Worry (Nagel 2018)	0.6	1.3	7.7	0.4	0.4	0.3	0.3	0.7	0.1	1.6	0.7	2.8
HbA1C	0.6	0.6	2.5	0.6	0.5	1.2	0.5	0.5	1.6	0.8	0.0	0.1
Triglycerides	0.6	1.0	1.7	-0.3	-1.2	-1.3	-1.3	-1.1	-1.2	0.3	-1.2	-0.3
Smoking Status	0.6	1.5	4.0	-0.2	-1.1	-0.2	-1.4	-1.6	-0.6	-2.0	-1.7	0.2
Chronotype (morning person)	0.6	1.4	4.2	0.9	-2.0	0.6	-1.0	-1.6	0.3	-0.0	-1.8	0.5
Average weekly spirits intake	0.6	0.8	1.8	0.3	0.9	0.3	0.8	1.2	0.6	1.0	1.3	0.9
Ever used hormone-replacement therapy (HRT)	0.6	0.8	2.9	1.3	-0.2	0.4	-0.1	0.9	1.7	0.4	0.7	0.8
Ever had hysterectomy (womb removed)	0.6	0.7	2.2	1.5	0.5	1.3	0.3	0.6	1.1	0.3	0.2	0.8
Diabetes (father)	0.6	0.7	2.4	-0.9	-0.4	0.1	-0.4	-0.7	-1.5	1.6	-0.5	-0.3
Hand grip strength (right)	0.6	1.7	4.3	0.6	2.1	1.1	2.0	1.5	0.1	-0.3	1.7	-0.0
Past tobacco smoking	0.6	1.1	5.7	-0.3	0.8	-0.5	0.7	1.1	0.4	2.4	1.1	0.1
Weight	0.6	3.0	5.9	-2.2	2.2	-0.8	2.0	1.0	-1.2	-1.5	1.2	-2.4
Mouth/teeth dental problems: Dentures	0.6	1.1	1.7	-0.7	-1.2	-0.4	-0.8	-1.2	-0.7	-1.2	-1.2	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	1.4	0.6	0.9	0.4	1.1	1.1	1.2	-0.2	1.0	0.6
Standing height	0.6	5.8	17.3	-4.2	2.2	-1.8	1.7	0.3	-4.0	-1.8	1.3	-1.8
Exposure to tobacco smoke at home	0.6	0.7	2.2	0.7	0.4	1.2	0.2	-0.2	1.0	-1.5	-0.5	-0.6
Birth weight	0.6	1.3	3.6	-0.4	1.3	1.4	1.9	0.7	0.5	-1.2	0.6	1.1
Pulse rate, automated reading	0.6	1.9	4.9	-0.4	2.2	0.2	1.9	1.7	0.8	0.9	1.9	-0.8
Friendships satisfaction	0.6	0.8	3.1	0.0	0.7	1.8	1.0	0.7	0.3	0.5	0.8	1.0
Wears glasses or contact lenses	0.6	0.7	1.1	-0.5	-1.1	0.0	-1.1	-1.0	0.5	-0.8	-1.0	0.8
Medication: Lisinopril	0.6	0.8	3.9	-0.2	0.6	0.7	0.5	0.0	-1.1	-0.6	0.6	-2.0
Diastolic blood pressure, automated reading	0.6	1.7	4.3	0.1	1.6	1.1	2.1	1.3	0.5	1.7	1.2	-1.2
Ever depressed for a whole week	0.6	0.7	2.6	1.6	1.2	0.3	0.5	0.9	0.4	0.0	0.8	0.7
Bipolar Disorder or Schizophrenia	0.5	1.1	3.5	1.9	-0.4	1.6	0.5	-0.0	1.4	-1.2	-0.4	0.4
Age at First Birth	0.5	0.7	2.2	-1.3	0.6	-1.5	0.1	0.5	-1.1	-0.1	0.7	0.3
HDL Cholesterol	0.5	0.8	4.0	-2.0	-0.1	0.2	-0.2	-0.5	0.1	-0.4	-0.4	-1.6
Cardiovascular Disease	0.5	1.5	8.9	3.0	0.3	-0.9	0.6	0.5	0.5	0.5	0.5	-1.6
Relative age of first facial hair	0.5	1.1	2.5	-0.8	-1.6	-0.2	-1.3	-1.2	-1.0	0.9	-1.0	-0.8
Medication for hormone replacement therapy	0.5	0.5	1.7	-0.1	-1.2	1.3	-0.5	-0.4	0.8	-0.5	-0.6	-0.1
Diabetes (mother)	0.5	0.7	1.5	0.8	0.8	0.3	0.6	0.8	1.2	0.9	0.7	-0.8
Severe depression (siblings)	0.5	0.6	1.7	0.5	-0.9	0.0	-1.0	-0.9	0.4	-0.6	-1.3	-0.3
Pack years adult smoking proportion	0.5	0.7	3.6	0.9	-0.3	1.9	0.2	-0.1	0.7	0.0	-0.4	1.1
Sitting height	0.5	3.4	6.9	-2.1	2.6	-0.7	2.3	1.2	-2.2	-2.0	1.8	-0.9
Hair/balding pattern: Pattern 2	0.5	0.7	1.9	0.3	-1.3	0.0	-1.4	-0.9	-0.7	0.0	-0.7	0.7
Hair/balding pattern: Pattern 3	0.5	0.7	3.0	-0.1	-0.5	-1.5	-0.6	-0.2	-0.6	1.7	0.0	0.3
Number of live births	0.5	0.7	1.8	1.3	-0.7	-0.6	-0.6	-0.3	1.0	1.0	-0.6	-0.9
Noisy workplace	0.5	0.6	1.9	-0.0	-0.3	1.4	-0.6	-0.7	-0.3	-1.2	-0.9	0.3
Depression (self-reported)	0.5	0.6	1.8	0.6	-0.1	1.1	-0.2	-0.2	1.0	0.5	-0.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	2.1	1.5	0.7	0.9	0.1	0.7	0.9	0.7	0.4	1.2
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	6.2	0.3	-0.7	-2.5	0.5	-0.6	-0.3	0.5	-0.4	0.7
Health satisfaction	0.5	0.6	2.7	0.4	-0.3	1.7	0.5	-0.1	1.1	-0.8	-0.5	-0.2
Shortness of breath walking on level ground	0.5	0.6	3.1	-0.7	-0.6	0.3	-0.7	-0.6	-0.1	-0.5	-0.7	-1.8
Comparative height size at age 10	0.5	2.6	5.5	-1.6	2.3	-1.4	1.6	0.9	-2.3	-0.3	1.5	-1.4
Overall health rating	0.5	1.0	2.0	0.3	1.0	0.7	1.4	1.1	1.4	-1.0	0.8	-0.7
Supplements: Vitamin C	0.5	0.6	1.9	0.3	-0.3	0.9	0.2	-0.1	1.4	-0.9	-0.4	-1.1
Hypertension (Self-reported)	0.5	1.3	10.2	0.4	0.3	0.6	0.4	0.3	-0.0	0.7	0.5	-3.2
Osteoporosis (self-reported)	0.5	0.6	1.3	-1.1	-1.0	-0.2	-0.6	-0.6	-1.0	0.5	-0.2	-1.1
Illnesses of father: None of the above (group 1)	0.5	0.6	1.3	-1.1	1.1	-0.5	0.8	0.4	-0.8	-1.1	0.2	-0.2
Vascular/heart problems diagnosed by doctor	0.5	1.3	10.3	-0.2	0.6	0.3	0.5	0.5	0.3	-0.2	0.4	3.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	3.7	1.9	0.2	0.2	-0.0	0.4	1.0	0.3	0.3	1.0
Pack years of smoking	0.5	0.7	3.2	0.2	-0.9	1.8	-0.4	-0.8	0.1	0.3	-1.0	0.4
Depressed Affect (Nagel 2018)	0.4	0.9	2.5	0.4	0.9	0.8	0.9	1.0	1.4	0.1	0.7	1.6
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.9	-0.5	-1.7	1.4	-1.2	-1.3	-0.3	-1.2	-1.3	0.2
Alzheimer’s Disease (including proxy)	0.4	0.5	1.8	0.4	-0.7	-0.7	-1.1	-0.6	-0.4	1.3	-0.4	-0.1
Ulcerative Colitis (UC)	0.4	0.8	1.6	-0.5	0.0	0.1	-1.1	-1.2	-1.3	-0.9	-1.3	-0.0
Breast Cancer	0.4	1.0	1.9	-0.8	-1.4	-0.5	-1.4	-0.9	-0.9	1.3	-0.8	0.2
Heel T-Score	0.4	2.9	5.6	-2.3	-1.6	-1.9	-1.9	-1.6	-2.4	-0.7	-1.2	-1.2
Waist Hip Ratio (WHR)	0.4	1.6	6.6	2.6	-1.1	1.6	-0.4	-0.7	1.4	-0.4	-1.2	0.6
Townsend deprivation index at recruitment	0.4	0.5	1.0	0.1	-0.6	0.6	-0.6	-1.0	-0.6	-0.4	-1.0	-1.0
Age when periods started (menarche)	0.4	0.9	5.2	-0.3	0.1	2.3	-0.1	-0.2	-0.4	0.3	-0.2	-1.5
High blood pressure	0.4	1.2	9.3	0.4	0.3	0.5	0.5	0.3	0.3	0.5	0.3	-3.1
High blood pressure (mother)	0.4	0.5	1.3	0.4	0.3	1.1	0.6	-0.0	1.2	-1.1	-0.5	-0.1
Impedance of leg (left)	0.4	1.8	3.7	0.1	-1.9	1.1	-1.8	-1.6	-0.9	-0.0	-1.7	1.4
Impedance of arm (right)	0.4	2.0	5.1	0.2	-2.1	0.8	-2.3	-1.7	-1.2	0.6	-1.7	0.5
Worrier / anxious feelings	0.4	0.7	4.3	0.4	0.3	-0.1	-0.2	0.3	-0.2	1.2	0.3	2.1
Falls in the last year	0.4	0.5	1.6	1.3	0.8	0.5	0.5	0.8	0.7	0.4	0.6	0.5
Happiness	0.4	0.5	1.6	0.5	0.7	0.5	0.8	0.5	-0.2	0.7	0.7	1.3
Medication: Lansoprazole	0.4	0.5	1.5	0.2	0.7	-0.1	0.7	1.1	1.2	0.0	0.8	0.3
Pulse wave reflection index	0.4	0.5	1.3	-0.6	-0.6	-0.5	-0.9	-0.8	-1.1	-0.4	-0.8	-0.6
Headache pain in last month	0.4	0.6	2.6	-1.3	0.3	-1.6	-0.4	-0.1	-0.4	0.4	-0.0	0.9
Medication: Amlodipine	0.4	0.6	1.4	-1.1	-0.7	0.1	-1.0	-0.5	-0.7	0.5	-0.6	-1.2
Chronic bronchitis/emphysema (mother)	0.4	0.4	2.2	-1.1	-0.4	0.1	-0.3	-0.4	-1.5	0.0	-0.3	-0.0
Qualifications: College or University degree	0.4	1.4	3.2	-0.2	-1.8	-0.7	-1.6	-1.4	-1.7	0.1	-1.0	-0.4
Mouth/teeth dental problems: Loose teeth	0.4	0.4	2.1	1.4	0.4	0.3	0.7	0.5	0.2	-0.8	0.5	0.1
Alcohol intake frequency.	0.4	0.9	6.5	0.3	-0.1	0.0	0.1	-0.5	0.1	-0.7	-0.8	-2.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.4	2.4	0.8	-0.1	0.4	-0.1	0.3	-0.1	1.6	0.5	0.6
Average weekly red wine intake	0.4	0.5	2.1	-0.7	-0.3	0.1	-0.6	-0.6	-0.7	0.8	-0.5	-1.4
Qualifications: nursing, teaching	0.4	0.7	2.5	-0.2	0.5	1.2	0.4	0.2	0.2	-1.6	0.2	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	2.5	-0.7	0.4	1.6	0.3	-0.5	-0.4	-1.0	-0.8	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	3.6	-0.1	-0.0	-0.3	0.5	0.3	-0.1	-0.7	0.3	1.9
Financial situation satisfaction	0.4	0.5	2.5	0.4	0.7	0.1	0.8	0.6	1.6	-0.1	0.0	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.3	-1.0	0.1	-1.0	-0.1	0.4	-0.8	1.1	0.7	-0.1
Impedance of whole body	0.4	2.2	5.2	0.2	-2.3	0.7	-2.2	-1.9	-0.9	0.1	-1.9	1.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	0.7	-0.6	-0.4	-1.0	-0.6	-0.5	0.2	-0.4	0.7
Body Mass Index (BMI) (2010)	0.3	0.4	1.3	-1.1	-0.4	-0.7	-0.3	-0.4	-0.2	-0.9	-0.3	-0.7
Blood Red Count	0.3	3.0	9.5	0.2	2.5	1.6	2.2	1.5	3.1	-1.2	0.6	-0.1
Neuroticism	0.3	0.7	2.4	-0.4	0.6	-0.7	-0.0	0.6	-0.5	1.3	0.7	1.5
Hand grip strength (left)	0.3	0.8	1.8	0.4	1.2	1.4	1.1	0.8	-0.1	0.8	1.0	0.1
Number of treatments/medications taken	0.3	0.5	3.4	0.4	-0.7	0.1	-0.4	-0.4	0.1	-0.1	-0.5	-1.9
Impedance of leg (right)	0.3	1.5	3.2	0.2	-1.8	1.2	-1.6	-1.5	-0.5	-0.1	-1.6	1.1
Trunk fat percentage	0.3	1.2	5.2	-1.2	-0.5	0.4	-0.5	-0.9	-0.6	-1.2	-0.9	-2.3
Medication: Levothyroxine sodium	0.3	0.6	1.5	0.9	-1.0	-1.2	0.2	-1.0	0.1	-0.4	-1.0	-0.0
Trunk fat mass	0.3	1.5	6.5	-1.9	0.4	-0.2	0.3	-0.4	-1.0	-1.3	-0.3	-2.5
Waist circumference	0.3	1.3	3.2	-0.3	1.8	0.3	1.7	0.9	0.3	-1.1	0.8	-1.5
Number of incorrect matches in round	0.3	0.5	1.2	-0.8	-0.9	0.6	-0.5	-0.8	-1.1	-0.6	-0.4	-0.6
Alcohol usually taken with meals	0.3	0.6	1.7	0.2	0.4	0.4	1.2	0.6	1.3	-0.7	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	1.4	0.8	0.7	-0.3	0.5	0.3	1.2	-0.1	0.1	1.0
Mouth/teeth dental problems	0.3	0.5	3.4	-0.2	0.2	-1.9	-0.1	0.3	-0.1	0.8	0.5	-0.1
Pain all over the body in last month	0.3	0.3	1.0	-0.2	0.8	-0.2	0.5	0.8	0.0	0.4	1.0	-0.0
Medication: Ramipril	0.3	0.4	1.7	1.0	-0.4	-0.5	-0.2	-0.0	0.0	-0.3	0.1	1.3
Fluid intelligence score	0.3	0.6	1.7	-0.4	-1.3	0.6	-0.9	-0.8	-0.5	-0.0	-0.9	0.3
Neuroticism score	0.3	0.7	3.4	0.9	0.8	-0.1	0.5	0.7	0.1	0.6	0.7	1.8
Prospective memory result	0.3	0.3	1.4	-0.5	-0.7	-0.1	-0.2	-0.5	-0.7	0.4	-0.4	-1.2
Lung cancer (father)	0.3	0.4	1.6	0.4	-0.4	0.4	-0.8	-0.3	-0.8	-0.3	-0.0	-1.3
Illnesses of mother	0.3	0.4	1.2	-0.7	-0.4	0.6	-0.1	-0.3	-0.6	1.1	-0.2	-0.8
Impedance of arm (left)	0.3	1.2	3.2	0.7	-1.6	0.4	-1.8	-1.3	-0.6	0.2	-1.3	0.9
Arm fat mass (right)	0.3	1.3	5.7	-1.5	1.0	-0.4	0.8	0.2	-0.5	-1.0	0.4	-2.4
Hair/balding pattern: Pattern 4	0.3	0.8	1.8	0.4	1.3	0.4	1.1	1.1	0.2	-0.3	1.4	-0.8
Body fat percentage	0.3	1.1	4.2	-1.0	-0.6	0.5	-0.6	-1.0	-0.3	-1.2	-1.1	-2.0
Exposure to tobacco smoke outside home	0.3	0.3	1.7	0.3	0.3	0.8	0.4	0.0	0.6	-1.3	-0.1	-0.1
Comparative body size at age 10	0.3	0.8	2.5	0.5	0.8	-1.0	0.3	0.6	-0.6	1.1	0.9	1.6
Medication for pain relief, constipation, heartburn	0.3	0.4	2.1	-0.5	0.5	0.5	0.1	0.7	-0.1	1.4	0.7	0.1
Medication: Seretide 50 evohaler	0.3	0.4	1.6	-0.2	-0.2	0.1	-0.8	-0.3	0.2	-1.3	-0.7	-0.5
Whole body fat mass	0.3	1.4	6.1	-1.8	0.3	-0.2	0.2	-0.5	-0.9	-1.4	-0.4	-2.5
Leg fat mass (right)	0.3	1.0	4.1	-1.3	0.5	-0.1	0.6	-0.3	-0.4	-1.5	-0.3	-2.0
Had major operations	0.3	0.4	2.0	-1.4	-0.3	-0.7	-0.5	-0.1	-0.6	-0.5	0.1	-0.1
Age at last live birth	0.3	0.5	1.1	-0.6	-0.8	-0.0	-0.8	-0.8	0.4	-0.4	-1.1	0.9
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.9	0.5	-0.1	-0.4	-0.0	0.1	0.9	-0.4	0.0	1.4
Illnesses of siblings: Diabetes	0.3	0.4	1.3	1.1	-0.4	0.4	-0.5	-0.4	-0.1	0.5	-0.4	1.1
Smoking status: Previous	0.3	0.4	1.9	0.4	-0.5	0.4	-0.4	-0.7	-0.7	-1.4	-0.6	-0.3
Long-standing illness, disability or infirmity	0.3	0.5	1.9	0.6	-0.1	-1.0	-0.5	-0.2	-0.5	-0.8	-0.2	-1.4
Ever had bowel cancer screening	0.3	0.4	0.9	1.0	-0.5	-0.9	-0.9	-0.1	0.2	0.3	-0.3	-0.3
Eye problems/disorders: Cataract	0.3	0.3	2.1	0.5	-0.4	-1.4	0.5	0.1	0.5	0.1	0.0	0.0
Arm fat mass (left)	0.3	1.4	6.7	-1.4	1.1	-0.3	1.0	0.3	-0.5	-1.1	0.5	-2.6
Number of self-reported non-cancer illnesses	0.3	0.6	2.4	0.3	-0.4	-1.2	-0.7	-0.3	-0.3	-0.7	-0.4	-1.5
Guilty feelings	0.3	0.4	3.1	0.1	-0.3	0.4	0.1	0.2	0.6	-0.4	-0.1	1.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.2	0.7	-0.8	0.4	0.8	0.2	0.4	0.8	-0.5
Pain experienced in last month	0.3	0.5	3.4	1.8	-0.5	0.8	-0.2	-0.3	0.5	-0.1	-0.5	-0.1
Alcohol drinker status: Previous	0.3	0.4	1.3	1.1	-0.2	0.5	0.1	0.0	0.7	-1.0	-0.1	0.7
Type 2 Diabetes (T2D) (2012)	0.2	0.2	1.6	-0.2	0.1	1.2	0.2	0.2	0.2	-0.5	0.1	0.2
BMI	0.2	1.3	3.0	-0.0	1.5	0.9	1.5	0.9	0.7	-1.1	0.8	-1.7
Tanning	0.2	2.2	5.0	1.0	-2.0	0.3	-1.2	-2.0	-0.9	-1.4	-2.2	-0.9
Hearing difficulty/problems: Yes	0.2	0.4	1.2	-1.0	0.9	-1.1	0.1	0.2	-0.2	-0.2	0.2	-0.1
Fed-up feelings	0.2	0.4	0.7	-0.6	0.6	-0.3	0.8	0.9	0.4	-0.1	0.9	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	-0.2	0.8	0.7	-0.0	0.3	-0.0	0.7	0.2	0.6
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	1.2	-0.2	-0.1	-0.3	-0.3	0.0	-0.4	-1.1	0.4	-0.5
Multivitamins +/- minerals	0.2	0.3	0.7	-0.9	-0.4	-0.4	-0.6	-0.6	-0.4	-0.1	-0.7	0.7
Diverticular disease/diverticulitis (self-reported)	0.2	0.3	1.1	-1.0	0.5	0.1	0.8	0.1	-0.3	-0.2	0.2	-0.4
Body mass index (BMI)	0.2	1.0	3.5	-0.5	1.3	-0.0	1.3	0.8	0.6	-0.9	0.7	-1.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.8	1.3	0.3	0.3	0.3	0.2	0.4	-0.5	-0.0	0.2
Alcohol intake versus 10 years previously	0.2	0.3	1.5	-0.1	0.3	0.7	0.1	0.0	-0.3	-0.5	-0.1	-1.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.2	0.7	-0.4	0.3	0.5	-0.1	-1.1	0.3	0.4
Loud music exposure frequency	0.2	0.2	0.6	0.3	0.7	-0.3	0.4	0.3	-0.8	-0.2	0.6	0.1
Qualifications: O levels/GCSEs or equivalent	0.2	0.3	0.8	-0.8	-0.3	-0.3	0.0	-0.8	-0.9	0.3	-0.8	0.3
Medication: Paracetamol	0.2	0.4	1.1	0.1	0.1	0.5	0.8	0.0	0.8	-1.0	-0.2	1.0
Leg fat percentage (right)	0.2	0.7	1.9	-0.4	-0.3	0.9	-0.1	-0.7	0.3	-1.3	-0.9	-1.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.3	0.8	0.9	0.5	-0.2	0.2	0.4	0.5	0.7	0.4	0.1
Mineral and other dietary supplements	0.2	0.3	1.1	0.9	0.2	0.2	0.2	-0.1	0.5	-1.1	-0.2	0.1
Leg fat percentage (left)	0.2	0.6	1.5	-0.5	-0.4	0.8	-0.3	-0.8	0.0	-1.2	-1.0	-1.2
Risk taking	0.2	0.3	1.6	0.6	0.2	1.3	0.1	-0.1	-0.1	0.1	-0.2	0.7
Unable to work because of sickness or disability	0.2	0.2	0.6	0.6	0.4	-0.1	0.6	0.4	0.2	-0.8	0.3	-0.1
Commuting to job workplace: Cycle	0.2	0.2	0.8	-0.7	-0.2	0.6	0.0	-0.4	0.1	0.9	-0.5	-0.4
Myopia	0.2	0.3	2.3	0.4	-0.1	0.2	0.5	0.1	0.5	-1.5	-0.1	0.0
Leg fat mass (left)	0.2	1.0	3.7	-1.4	0.5	-0.1	0.5	-0.3	-0.6	-1.4	-0.3	-1.9
Depression (Nagel 2018)	0.1	0.1	0.2	-0.5	-0.2	0.4	-0.4	-0.2	0.2	0.0	-0.4	0.5
Major Depression (MDD)	0.1	0.2	1.1	0.7	0.0	0.0	0.0	0.0	0.0	-1.1	0.0	0.0
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.5	-0.4	-0.5	-0.0	-0.1	-0.2	-0.5	0.1	-0.1	0.7
Systolic Blood Pressure	0.1	0.7	1.5	0.6	-1.0	0.6	-0.3	-0.7	0.6	1.1	-1.0	-1.2
Hair Pigment	0.1	3.5	10.8	3.3	-1.8	1.9	-0.8	-1.0	1.1	-1.4	-1.6	2.5
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	-0.5	-0.3	-0.6	-0.6	-0.1	-0.2	0.4	-0.1	0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.5	0.3	-0.3	0.2	0.1	0.4	-0.7	0.2	-0.3
Vitamin and mineral supplements	0.1	0.2	0.5	0.7	0.0	-0.4	-0.1	-0.0	-0.7	-0.1	0.3	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	1.0	-0.0	-0.8	0.3	-0.7	-0.2	-0.5	-0.1	-0.2	1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.7	0.1	-0.6	0.8	-0.3	-0.1	0.1	0.3	-0.2	0.3
Qualifications: None of the above	0.1	0.2	0.8	-0.1	-0.1	0.6	0.1	0.1	0.7	0.9	-0.1	-0.5
Arm fat percentage (right)	0.1	0.6	4.2	-0.6	0.2	0.5	0.1	-0.1	0.1	-0.5	-0.2	-2.0
Qualifications: A levels/AS levels or equivalent	0.1	0.3	1.5	-0.3	-0.3	0.2	-0.2	-0.6	-0.8	0.3	-0.4	1.2
Glaucoma (self-reported)	0.1	0.2	1.1	0.2	-0.0	0.2	-0.3	-0.0	-0.0	-1.0	0.1	0.3
Chest pain or discomfort	0.1	0.1	0.3	0.5	0.5	0.4	0.5	0.1	0.3	-0.3	-0.1	-0.3
Arm fat percentage (left)	0.1	0.5	3.5	-0.4	0.3	0.2	0.2	-0.1	0.2	-0.7	-0.2	-1.9
Eye problems/disorders: Glaucoma	0.1	0.2	0.8	0.9	-0.1	-0.3	-0.3	-0.0	-0.2	-0.4	0.2	-0.6
Number of operations (self-reported)	0.1	0.1	0.7	0.1	0.1	-0.0	-0.2	0.2	-0.2	-0.3	0.2	0.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.1	0.2	-0.3	0.2	-0.3	-0.3	-0.2	-0.1	-0.2	-0.0

Hub : Genes

CDKN2D

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Trait associations