Best TWAS P=1.3e-17 · Best GWAS P=4.68e-16 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC134 | 0.06 | 0.07 | enet | 5 | 0.06 | 1.2e-07 | -4.1 | -5.1 | 3.1e-07 | -0.03 | 0.01 | 0.99 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | EP300 | 0.05 | 0.00 | bslmm | 289 | 0.02 | 3.2e-03 | 4.1 | -5.8 | 8.6e-09 | 0.16 | 0.44 | 0.07 | FALSE |
3 | GTEx | Adipose Visceral Omentum | TNRC6B | 0.11 | 0.00 | lasso | 4 | 0.01 | 1.5e-01 | -2.3 | -6.7 | 1.5e-11 | 0.26 | 0.04 | 0.38 | TRUE |
4 | GTEx | Brain Cerebellar Hemisphere | CYP2D7P1 | 0.39 | 0.09 | enet | 12 | 0.20 | 7.2e-06 | -3.1 | -5.1 | 2.7e-07 | 0.04 | 0.18 | 0.44 | FALSE |
5 | GTEx | Brain Frontal Cortex BA9 | SLC25A17 | 0.11 | -0.01 | lasso | 5 | 0.00 | 3.5e-01 | -4.5 | -5.2 | 1.7e-07 | 0.35 | 0.08 | 0.15 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | CYP2D7P1 | 0.32 | 0.00 | lasso | 8 | 0.02 | 9.7e-02 | 4.1 | -5.9 | 4.9e-09 | 0.02 | 0.03 | 0.06 | TRUE |
7 | GTEx | Liver | L3MBTL2 | 0.13 | 0.08 | lasso | 7 | 0.09 | 1.3e-03 | -4.8 | 5.2 | 2.1e-07 | 0.00 | 0.07 | 0.54 | FALSE |
8 | GTEx | Skin Sun Exposed Lower leg | CENPM | 0.05 | 0.00 | enet | 8 | 0.02 | 1.5e-02 | -3.8 | 5.6 | 2.1e-08 | 0.00 | 0.09 | 0.23 | FALSE |
9 | GTEx | Thyroid | ZC3H7B | 0.11 | 0.07 | enet | 7 | 0.07 | 3.9e-06 | 4.1 | 5.3 | 1.2e-07 | -0.14 | 0.30 | 0.33 | TRUE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADSL | 0.05 | 0.01 | enet | 7 | 0.01 | 4.2e-04 | -2.6 | -5.4 | 6.2e-08 | 0.46 | 0.06 | 0.29 | TRUE |
11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TNRC6B | 0.02 | 0.01 | blup | 92 | 0.01 | 2.7e-03 | -7.4 | -8.3 | 8.7e-17 | 0.85 | 0.02 | 0.74 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | MKL1 | 0.05 | 0.03 | blup | 105 | 0.04 | 3.9e-03 | -3.8 | -5.4 | 8.4e-08 | 0.38 | 0.04 | 0.24 | TRUE |
13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ADSL | 0.04 | 0.03 | enet | 6 | 0.03 | 1.6e-04 | -8.1 | -7.8 | 8.8e-15 | 0.90 | 0.00 | 0.94 | TRUE |
14 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADSL | 0.07 | 0.02 | blup | 33 | 0.05 | 5.2e-04 | -5.3 | -7.4 | 1.2e-13 | 0.68 | 0.08 | 0.48 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SGSM3 | 0.07 | 0.02 | blup | 43 | 0.03 | 1.1e-02 | -2.4 | -5.4 | 8.1e-08 | 0.23 | 0.05 | 0.04 | FALSE |
16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | TNRC6B | 0.05 | 0.03 | lasso | 8 | 0.04 | 6.9e-06 | -5.8 | -7.6 | 2.3e-14 | 0.54 | 0.50 | 0.42 | FALSE |
17 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADSL | 0.03 | 0.00 | blup | 33 | 0.01 | 8.9e-03 | -7.9 | -8.5 | 1.3e-17 | 0.84 | 0.01 | 0.60 | TRUE |
18 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | ADSL | 0.06 | 0.02 | lasso | 2 | 0.03 | 6.6e-03 | -8.0 | -7.7 | 1.6e-14 | 0.97 | 0.00 | 0.81 | FALSE |
19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ADSL | 0.09 | 0.03 | lasso | 3 | 0.01 | 7.7e-02 | -8.1 | -8.0 | 1.2e-15 | 0.92 | 0.00 | 0.75 | FALSE |
20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SGSM3 | 0.06 | 0.01 | lasso | 4 | 0.01 | 7.4e-02 | 7.5 | -5.8 | 6.2e-09 | 0.30 | 0.02 | 0.33 | FALSE |
21 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ADSL | 0.14 | 0.05 | lasso | 3 | 0.06 | 1.5e-04 | -4.8 | -6.0 | 1.6e-09 | 0.45 | 0.56 | 0.05 | FALSE |
22 | The Cancer Genome Atlas | Stomach Adenocarcinoma | ADSL | 0.04 | 0.00 | blup | 33 | 0.03 | 2.6e-03 | -5.4 | -8.3 | 1.0e-16 | 0.68 | 0.02 | 0.74 | FALSE |
23 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MKL1 | 0.05 | 0.01 | blup | 95 | 0.02 | 2.2e-02 | 6.4 | -6.9 | 5.6e-12 | 0.47 | 0.01 | 0.92 | TRUE |