Best TWAS P=4.68e-34 · Best GWAS P=1.59e-52 conditioned to 7.53e-14
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | SLC2A9 | 0.06 | 0.01 | blup | 565 | 0.02 | 6.2e-04 | -5.0 | -6.9 | 3.8e-12 | 0.04 | 0.48 | 0.08 | TRUE |
2 | GTEx | Adipose Subcutaneous | TRMT44 | 0.20 | 0.19 | lasso | 8 | 0.19 | 9.4e-16 | -7.3 | -5.4 | 7.2e-08 | -0.04 | 1.00 | 0.00 | FALSE |
3 | GTEx | Adipose Visceral Omentum | SLC2A9 | 0.15 | 0.02 | lasso | 4 | 0.04 | 3.6e-03 | -5.7 | -6.5 | 6.3e-11 | 0.04 | 0.29 | 0.12 | FALSE |
4 | GTEx | Adipose Visceral Omentum | TRMT44 | 0.11 | 0.11 | lasso | 2 | 0.08 | 9.2e-05 | -5.5 | -5.4 | 8.5e-08 | 0.02 | 0.86 | 0.01 | FALSE |
5 | GTEx | Adrenal Gland | ACOX3 | 0.15 | 0.12 | lasso | 6 | 0.13 | 2.5e-05 | -6.9 | -6.9 | 6.9e-12 | 0.07 | 0.70 | 0.02 | FALSE |
6 | GTEx | Artery Aorta | TRMT44 | 0.11 | 0.11 | lasso | 4 | 0.10 | 6.4e-06 | -5.5 | -5.7 | 1.3e-08 | 0.03 | 0.86 | 0.02 | FALSE |
7 | GTEx | Artery Tibial | TRMT44 | 0.10 | 0.06 | lasso | 6 | 0.06 | 1.6e-05 | -5.5 | -6.1 | 9.8e-10 | 0.06 | 0.94 | 0.00 | FALSE |
8 | GTEx | Brain Caudate basal ganglia | TRMT44 | 0.51 | 0.30 | lasso | 9 | 0.26 | 3.4e-08 | -5.4 | -5.5 | 4.3e-08 | 0.02 | 0.93 | 0.01 | FALSE |
9 | GTEx | Brain Cerebellar Hemisphere | TRMT44 | 0.41 | 0.26 | lasso | 5 | 0.20 | 5.8e-06 | -7.3 | -7.2 | 4.2e-13 | 0.08 | 0.79 | 0.01 | FALSE |
10 | GTEx | Brain Cerebellar Hemisphere | AFAP1 | 0.60 | 0.28 | lasso | 11 | 0.34 | 1.1e-09 | 9.3 | 8.5 | 2.5e-17 | -0.01 | 0.02 | 0.98 | FALSE |
11 | GTEx | Brain Cerebellar Hemisphere | RP11-689P11.2 | 0.45 | 0.14 | lasso | 5 | 0.19 | 1.4e-05 | -7.3 | -6.0 | 2.3e-09 | 0.05 | 0.52 | 0.04 | FALSE |
12 | GTEx | Brain Cerebellar Hemisphere | AFAP1-AS1 | 0.33 | 0.16 | lasso | 7 | 0.16 | 5.9e-05 | 9.3 | 9.0 | 1.9e-19 | 0.00 | 0.02 | 0.93 | TRUE |
13 | GTEx | Brain Cerebellum | GRPEL1 | 0.37 | 0.17 | lasso | 8 | 0.13 | 9.7e-05 | -6.0 | -5.8 | 5.7e-09 | 0.07 | 0.22 | 0.30 | FALSE |
14 | GTEx | Brain Cerebellum | TRMT44 | 0.48 | 0.16 | lasso | 10 | 0.18 | 4.4e-06 | -5.4 | -5.2 | 2.6e-07 | 0.03 | 0.58 | 0.06 | FALSE |
15 | GTEx | Brain Cerebellum | AFAP1 | 0.47 | 0.19 | lasso | 4 | 0.19 | 2.8e-06 | -6.1 | 8.6 | 7.9e-18 | 0.00 | 0.03 | 0.95 | FALSE |
16 | GTEx | Brain Cerebellum | RP11-689P11.2 | 0.28 | 0.11 | lasso | 2 | 0.17 | 1.0e-05 | -7.3 | -5.2 | 2.0e-07 | 0.07 | 0.18 | 0.18 | FALSE |
17 | GTEx | Brain Cerebellum | AFAP1-AS1 | 0.47 | 0.05 | lasso | 10 | 0.10 | 7.6e-04 | 3.5 | 7.8 | 4.2e-15 | 0.01 | 0.04 | 0.72 | FALSE |
18 | GTEx | Brain Cortex | TRMT44 | 0.29 | 0.22 | enet | 20 | 0.24 | 3.2e-07 | -7.3 | -6.2 | 5.3e-10 | 0.00 | 0.62 | 0.04 | FALSE |
19 | GTEx | Brain Frontal Cortex BA9 | RP11-689P11.2 | 0.28 | 0.03 | lasso | 4 | 0.12 | 4.1e-04 | -5.7 | -5.7 | 1.3e-08 | 0.07 | 0.20 | 0.05 | FALSE |
20 | GTEx | Brain Hypothalamus | SLC2A9 | 0.42 | -0.01 | enet | 39 | 0.03 | 6.9e-02 | -5.7 | -6.1 | 1.0e-09 | 0.07 | 0.07 | 0.11 | FALSE |
21 | GTEx | Brain Hypothalamus | TRMT44 | 0.38 | 0.19 | lasso | 5 | 0.13 | 6.1e-04 | -7.5 | -6.7 | 2.7e-11 | 0.05 | 0.46 | 0.03 | FALSE |
22 | GTEx | Brain Nucleus accumbens basal ganglia | TRMT44 | 0.25 | 0.19 | lasso | 5 | 0.17 | 2.1e-05 | -7.3 | -6.9 | 4.4e-12 | 0.08 | 0.40 | 0.03 | FALSE |
23 | GTEx | Breast Mammary Tissue | TRMT44 | 0.19 | 0.22 | lasso | 5 | 0.20 | 2.2e-10 | -7.2 | -6.9 | 6.3e-12 | 0.07 | 1.00 | 0.00 | FALSE |
24 | GTEx | Breast Mammary Tissue (Male) | TRMT44 | 0.22 | 0.03 | lasso | 8 | 0.01 | 2.1e-01 | -5.7 | -6.5 | 9.2e-11 | 0.10 | 0.07 | 0.06 | FALSE |
25 | GTEx | Breast Mammary Tissue (Female) | TRMT44 | 0.23 | 0.19 | enet | 12 | 0.19 | 2.5e-06 | -7.2 | -5.1 | 3.1e-07 | 0.02 | 0.67 | 0.02 | FALSE |
26 | GTEx | Breast Mammary Tissue (Female) | RP11-689P11.3 | 0.12 | 0.07 | lasso | 2 | 0.08 | 2.5e-03 | -7.3 | -6.6 | 3.6e-11 | 0.07 | 0.14 | 0.06 | FALSE |
27 | GTEx | Cells EBV-transformed lymphocytes | GRPEL1 | 0.25 | 0.12 | enet | 7 | 0.06 | 3.9e-03 | -5.9 | -5.7 | 1.4e-08 | 0.05 | 0.24 | 0.37 | FALSE |
28 | GTEx | Cells EBV-transformed lymphocytes | SLC2A9 | 0.25 | 0.18 | lasso | 6 | 0.18 | 2.0e-06 | -5.0 | -5.2 | 2.1e-07 | 0.05 | 0.86 | 0.06 | FALSE |
29 | GTEx | Cells EBV-transformed lymphocytes | RP11-689P11.2 | 0.17 | 0.13 | lasso | 4 | 0.12 | 1.1e-04 | -6.9 | -6.5 | 8.3e-11 | 0.04 | 0.68 | 0.02 | FALSE |
30 | GTEx | Cells Transformed fibroblasts | WDR1 | 0.09 | 0.03 | lasso | 4 | 0.03 | 2.1e-03 | -4.5 | 5.2 | 2.3e-07 | -0.06 | 0.29 | 0.03 | FALSE |
31 | GTEx | Cells Transformed fibroblasts | ACOX3 | 0.25 | 0.14 | lasso | 7 | 0.14 | 1.6e-10 | -7.3 | -7.6 | 3.5e-14 | 0.08 | 1.00 | 0.00 | FALSE |
32 | GTEx | Cells Transformed fibroblasts | GRPEL1 | 0.27 | 0.13 | lasso | 9 | 0.18 | 2.3e-13 | -4.8 | -5.6 | 2.5e-08 | 0.05 | 0.64 | 0.36 | FALSE |
33 | GTEx | Cells Transformed fibroblasts | AFAP1 | 0.26 | 0.10 | enet | 39 | 0.13 | 3.6e-10 | -4.9 | -6.6 | 5.3e-11 | -0.02 | 0.01 | 0.99 | FALSE |
34 | GTEx | Cells Transformed fibroblasts | AFAP1-AS1 | 0.20 | 0.09 | enet | 31 | 0.07 | 4.7e-06 | -9.8 | -6.7 | 2.1e-11 | -0.05 | 0.00 | 1.00 | FALSE |
35 | GTEx | Colon Transverse | TRMT44 | 0.17 | 0.05 | lasso | 5 | 0.02 | 4.4e-02 | -7.2 | -6.9 | 7.1e-12 | 0.09 | 0.24 | 0.04 | FALSE |
36 | GTEx | Esophagus Gastroesophageal Junction | RP11-689P11.2 | 0.30 | 0.21 | lasso | 7 | 0.25 | 1.2e-09 | -6.6 | -6.5 | 8.9e-11 | 0.07 | 0.99 | 0.00 | FALSE |
37 | GTEx | Esophagus Mucosa | AFAP1 | 0.48 | 0.40 | enet | 29 | 0.43 | 3.9e-31 | 7.6 | 8.0 | 1.0e-15 | -0.02 | 0.62 | 0.38 | FALSE |
38 | GTEx | Esophagus Mucosa | RP11-689P11.2 | 0.21 | 0.12 | lasso | 7 | 0.11 | 6.4e-08 | -6.9 | -6.3 | 2.4e-10 | 0.04 | 1.00 | 0.00 | FALSE |
39 | GTEx | Esophagus Mucosa | AFAP1-AS1 | 0.36 | 0.28 | lasso | 8 | 0.29 | 5.9e-20 | 7.6 | 7.4 | 1.1e-13 | -0.02 | 0.51 | 0.49 | FALSE |
40 | GTEx | Esophagus Muscularis | TRMT44 | 0.12 | 0.07 | lasso | 5 | 0.06 | 2.2e-04 | -7.3 | -6.5 | 5.9e-11 | 0.07 | 0.68 | 0.03 | FALSE |
41 | GTEx | Heart Atrial Appendage | ZNF518B | 0.10 | 0.01 | lasso | 3 | 0.00 | 4.6e-01 | -5.9 | 6.2 | 5.2e-10 | 0.01 | 0.02 | 0.86 | TRUE |
42 | GTEx | Liver | SLC2A9 | 0.18 | 0.13 | lasso | 6 | 0.12 | 3.7e-04 | -5.8 | -6.1 | 8.1e-10 | 0.00 | 0.30 | 0.13 | FALSE |
43 | GTEx | Lung | ACOX3 | 0.13 | 0.03 | lasso | 5 | 0.05 | 6.3e-05 | -7.3 | -5.7 | 1.4e-08 | 0.06 | 0.89 | 0.00 | FALSE |
44 | GTEx | Lung | SLC2A9 | 0.06 | 0.00 | lasso | 5 | 0.00 | 5.7e-01 | -5.4 | -6.7 | 2.4e-11 | 0.04 | 0.35 | 0.06 | FALSE |
45 | GTEx | Lung | TRMT44 | 0.13 | 0.10 | lasso | 6 | 0.08 | 1.3e-06 | -4.6 | -5.8 | 6.3e-09 | 0.05 | 0.99 | 0.00 | FALSE |
46 | GTEx | Lung | RP11-689P11.2 | 0.22 | 0.18 | lasso | 5 | 0.21 | 6.4e-16 | -4.5 | -6.0 | 1.7e-09 | 0.04 | 1.00 | 0.00 | FALSE |
47 | GTEx | Muscle Skeletal | GRPEL1 | 0.10 | 0.05 | lasso | 3 | 0.05 | 5.0e-06 | -4.9 | -5.2 | 2.3e-07 | 0.03 | 0.85 | 0.14 | FALSE |
48 | GTEx | Nerve Tibial | GRPEL1 | 0.16 | 0.07 | lasso | 4 | 0.06 | 2.9e-05 | -5.9 | -5.1 | 2.7e-07 | 0.05 | 0.46 | 0.34 | FALSE |
49 | GTEx | Nerve Tibial | TRMT44 | 0.27 | 0.26 | lasso | 5 | 0.27 | 5.4e-19 | -7.3 | -7.0 | 3.0e-12 | 0.08 | 1.00 | 0.00 | FALSE |
50 | GTEx | Nerve Tibial | RP11-689P11.2 | 0.32 | 0.11 | enet | 19 | 0.28 | 1.1e-19 | -4.5 | -5.3 | 1.2e-07 | 0.04 | 1.00 | 0.00 | FALSE |
51 | GTEx | Nerve Tibial | RP11-689P11.3 | 0.17 | 0.10 | lasso | 4 | 0.08 | 3.3e-06 | -5.5 | -5.5 | 4.7e-08 | 0.02 | 0.94 | 0.00 | FALSE |
52 | GTEx | Ovary | TRMT44 | 0.33 | 0.32 | lasso | 3 | 0.29 | 6.2e-08 | -6.6 | -7.0 | 2.7e-12 | 0.05 | 0.83 | 0.01 | FALSE |
53 | GTEx | Ovary | RP11-689P11.2 | 0.34 | 0.10 | lasso | 6 | 0.04 | 3.7e-02 | -4.5 | -5.5 | 3.5e-08 | 0.01 | 0.15 | 0.05 | FALSE |
54 | GTEx | Pancreas | SLC2A9 | 0.20 | 0.00 | enet | 16 | 0.03 | 1.5e-02 | -5.6 | -5.9 | 3.4e-09 | 0.01 | 0.22 | 0.21 | FALSE |
55 | GTEx | Pituitary | RP11-689P11.2 | 0.56 | 0.05 | lasso | 8 | 0.12 | 6.5e-04 | -7.5 | -6.0 | 2.4e-09 | 0.04 | 0.45 | 0.08 | FALSE |
56 | GTEx | Skin Not Sun Exposed Suprapubic | AFAP1 | 0.47 | 0.46 | lasso | 4 | 0.45 | 2.8e-27 | 7.6 | 7.7 | 1.6e-14 | -0.02 | 0.98 | 0.02 | FALSE |
57 | GTEx | Skin Not Sun Exposed Suprapubic | AFAP1-AS1 | 0.33 | 0.30 | lasso | 6 | 0.29 | 4.0e-16 | 7.6 | 7.5 | 5.9e-14 | -0.03 | 0.98 | 0.02 | FALSE |
58 | GTEx | Skin Sun Exposed Lower leg | SLC2A9 | 0.18 | 0.03 | enet | 15 | 0.06 | 1.2e-05 | -5.9 | -6.7 | 2.2e-11 | -0.01 | 0.28 | 0.54 | FALSE |
59 | GTEx | Skin Sun Exposed Lower leg | TBC1D14 | 0.11 | 0.08 | lasso | 2 | 0.07 | 1.5e-06 | -6.0 | -5.2 | 1.9e-07 | 0.05 | 0.24 | 0.70 | FALSE |
60 | GTEx | Skin Sun Exposed Lower leg | TRMT44 | 0.08 | 0.04 | lasso | 4 | 0.02 | 1.7e-02 | -7.5 | -6.6 | 4.7e-11 | 0.06 | 0.48 | 0.02 | FALSE |
61 | GTEx | Skin Sun Exposed Lower leg | AFAP1 | 0.50 | 0.45 | lasso | 8 | 0.46 | 4.2e-42 | 7.6 | 7.5 | 9.2e-14 | -0.02 | 1.00 | 0.00 | FALSE |
62 | GTEx | Skin Sun Exposed Lower leg | AFAP1-AS1 | 0.34 | 0.26 | lasso | 5 | 0.24 | 8.3e-20 | 7.6 | 7.6 | 3.7e-14 | -0.01 | 0.77 | 0.23 | FALSE |
63 | GTEx | Whole Blood | AFAP1 | 0.45 | 0.48 | enet | 44 | 0.50 | 1.3e-52 | 7.6 | 7.2 | 4.1e-13 | -0.01 | 0.98 | 0.02 | FALSE |
64 | GTEx | Whole Blood | AFAP1-AS1 | 0.36 | 0.33 | lasso | 8 | 0.33 | 2.6e-31 | 7.6 | 7.8 | 4.4e-15 | -0.01 | 0.48 | 0.52 | FALSE |
65 | METSIM | Adipose | AFAP1 | 0.05 | 0.03 | enet | 13 | 0.03 | 1.3e-05 | 7.6 | 8.2 | 3.7e-16 | -0.01 | 0.04 | 0.96 | FALSE |
66 | METSIM | Adipose | RP11-689P11.2 | 0.14 | 0.16 | enet | 25 | 0.17 | 4.2e-25 | -7.2 | -6.4 | 1.9e-10 | 0.05 | 1.00 | 0.00 | FALSE |
67 | METSIM | Adipose | SLC2A9 | 0.05 | 0.04 | lasso | 4 | 0.03 | 9.3e-06 | -5.7 | -5.9 | 4.4e-09 | 0.00 | 0.67 | 0.33 | FALSE |
68 | NTR | Blood | AFAP1 | 0.13 | 0.12 | lasso | 6 | 0.13 | 3.1e-39 | 7.6 | 6.4 | 1.2e-10 | 0.00 | 1.00 | 0.00 | FALSE |
69 | NTR | Blood | TBC1D14 | 0.05 | 0.03 | lasso | 7 | 0.02 | 7.5e-08 | -4.8 | 5.4 | 7.6e-08 | 0.00 | 0.66 | 0.34 | FALSE |
70 | YFS | Blood | TADA2B | 0.09 | 0.11 | lasso | 4 | 0.10 | 5.6e-32 | -4.9 | -5.2 | 1.7e-07 | 0.03 | 0.99 | 0.01 | FALSE |
71 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | GPR78 | 0.07 | 0.00 | blup | 65 | 0.02 | 1.7e-02 | 9.9 | -6.0 | 2.3e-09 | 0.44 | 0.00 | 0.57 | FALSE |
72 | The Cancer Genome Atlas | Breast Invasive Carcinoma | FLJ36777 | 0.04 | 0.02 | blup | 71 | 0.03 | 2.4e-07 | -5.8 | 5.7 | 1.4e-08 | -0.04 | 0.01 | 0.99 | FALSE |
73 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | ZNF518B | 0.08 | 0.04 | lasso | 2 | 0.01 | 1.2e-01 | 6.2 | 6.2 | 5.5e-10 | 0.02 | 0.02 | 0.28 | FALSE |
74 | The Cancer Genome Atlas | Colon Adenocarcinoma | FLJ36777 | 0.06 | 0.00 | blup | 69 | 0.04 | 4.0e-03 | -4.9 | 5.4 | 6.5e-08 | -0.01 | 0.02 | 0.25 | FALSE |
75 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CPZ | 0.03 | 0.00 | blup | 80 | 0.01 | 1.9e-02 | -5.9 | 12.2 | 4.7e-34 | -0.55 | 0.03 | 0.23 | TRUE |
76 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GRPEL1 | 0.09 | 0.10 | blup | 52 | 0.12 | 5.4e-13 | -5.9 | -5.6 | 2.7e-08 | 0.05 | 0.05 | 0.95 | FALSE |
77 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TADA2B | 0.02 | 0.01 | blup | 56 | 0.02 | 1.9e-03 | -6.0 | -6.7 | 1.7e-11 | 0.06 | 0.05 | 0.61 | TRUE |
78 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GRPEL1 | 0.06 | 0.09 | enet | 9 | 0.10 | 3.1e-11 | -4.8 | -5.3 | 1.3e-07 | 0.04 | 0.18 | 0.82 | FALSE |
79 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SLC2A9 | 0.11 | 0.11 | blup | 206 | 0.13 | 1.0e-14 | -5.4 | -6.1 | 9.5e-10 | 0.06 | 0.07 | 0.93 | FALSE |
80 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC2A9 | 0.06 | 0.02 | enet | 9 | 0.03 | 4.4e-04 | -4.8 | -5.5 | 3.4e-08 | 0.05 | 0.16 | 0.78 | FALSE |
81 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CPZ | 0.09 | 0.01 | blup | 80 | 0.03 | 4.4e-04 | -1.5 | 11.8 | 3.7e-32 | -0.54 | 0.02 | 0.52 | TRUE |
82 | The Cancer Genome Atlas | Prostate Adenocarcinoma | C4orf23 | 0.06 | 0.03 | enet | 11 | 0.03 | 3.1e-04 | -7.5 | -5.2 | 2.2e-07 | 0.04 | 0.00 | 0.99 | FALSE |
83 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CPZ | 0.10 | 0.12 | lasso | 4 | 0.13 | 3.1e-13 | 9.4 | 9.4 | 3.7e-21 | -0.49 | 1.00 | 0.00 | FALSE |
84 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GRPEL1 | 0.05 | 0.04 | blup | 52 | 0.05 | 9.0e-06 | -4.4 | -6.1 | 1.0e-09 | 0.06 | 0.08 | 0.91 | FALSE |
85 | The Cancer Genome Atlas | Thyroid Carcinoma | C4orf23 | 0.15 | 0.11 | blup | 90 | 0.13 | 5.2e-13 | -5.6 | -5.5 | 4.8e-08 | 0.06 | 0.03 | 0.97 | FALSE |
86 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC2A9 | 0.10 | 0.05 | blup | 208 | 0.05 | 2.7e-05 | -5.8 | -6.2 | 4.5e-10 | 0.02 | 0.02 | 0.96 | FALSE |
87 | The Cancer Genome Atlas | Thyroid Carcinoma | TBC1D14 | 0.06 | 0.04 | lasso | 2 | 0.05 | 7.6e-06 | -5.3 | 5.9 | 3.9e-09 | -0.03 | 0.04 | 0.94 | FALSE |
88 | The Cancer Genome Atlas | Thyroid Carcinoma | WDR1 | 0.12 | 0.05 | blup | 111 | 0.06 | 2.4e-06 | -4.1 | 5.6 | 1.8e-08 | -0.03 | 0.15 | 0.85 | FALSE |