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chr5:76,597,461-81,746,129

Best TWAS P=7.91e-32 · Best GWAS P=2.08e-42 conditioned to 3.06e-10

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	BHMT	0.33	0.34	bslmm	414	0.39	7.6e-50	5.07	-6.5	6.1e-11	-0.04	0.95	0.05	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DHFR	0.55	0.40	bslmm	503	0.65	4.9e-106	-4.66	6.9	5.1e-12	0.06	0.86	0.14	FALSE
3	GTEx	Adipose Subcutaneous	DHFR	0.29	0.19	lasso	15	0.24	1.5e-19	-4.60	5.6	2.6e-08	0.05	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	DHFR	0.21	0.26	lasso	9	0.24	5.3e-13	-4.66	5.7	1.0e-08	0.05	1.00	0.00	FALSE
5	GTEx	Adrenal Gland	DHFR	0.47	0.22	lasso	10	0.28	1.1e-10	7.07	8.0	1.1e-15	0.04	0.00	1.00	TRUE
6	GTEx	Artery Aorta	SSBP2	0.15	0.05	enet	11	0.13	1.6e-07	-4.70	7.2	5.2e-13	0.09	0.09	0.81	TRUE
7	GTEx	Artery Aorta	DHFR	0.30	0.23	lasso	6	0.24	2.6e-13	6.68	6.1	9.0e-10	0.03	0.01	0.99	FALSE
8	GTEx	Artery Coronary	DHFR	0.33	0.10	enet	45	0.13	3.9e-05	6.41	5.7	1.0e-08	0.03	0.02	0.95	FALSE
9	GTEx	Artery Tibial	DHFR	0.30	0.19	enet	43	0.25	1.1e-19	4.75	6.3	2.3e-10	0.04	0.48	0.52	FALSE
10	GTEx	Artery Tibial	CTD-2037K23.2	0.08	0.04	enet	13	0.07	4.3e-06	5.84	7.1	9.7e-13	-0.12	0.90	0.00	TRUE
11	GTEx	Brain Caudate basal ganglia	DHFR	0.31	0.24	enet	46	0.21	1.1e-06	-4.55	5.6	2.8e-08	0.05	0.93	0.04	FALSE
12	GTEx	Brain Cortex	ARSB	0.40	0.16	lasso	7	0.15	7.2e-05	-5.47	5.9	3.3e-09	0.03	0.62	0.02	FALSE
13	GTEx	Brain Cortex	DHFR	0.41	0.34	lasso	15	0.36	1.0e-10	-4.08	5.3	1.0e-07	0.04	0.92	0.07	FALSE
14	GTEx	Brain Frontal Cortex BA9	DHFR	0.59	0.33	lasso	12	0.50	3.0e-15	-4.55	5.5	4.1e-08	0.04	0.69	0.31	FALSE
15	GTEx	Brain Hypothalamus	DHFR	0.39	0.31	lasso	16	0.35	5.7e-09	-4.58	6.5	5.9e-11	0.05	0.22	0.76	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	DHFR	0.28	0.01	lasso	17	0.04	3.8e-02	-4.66	5.6	2.6e-08	0.05	0.08	0.68	FALSE
17	GTEx	Brain Putamen basal ganglia	DHFR	0.27	0.09	lasso	6	0.05	2.5e-02	4.75	5.5	3.1e-08	0.03	0.04	0.70	FALSE
18	GTEx	Breast Mammary Tissue	DHFR	0.28	0.18	lasso	7	0.27	2.3e-14	-4.61	5.5	3.1e-08	0.05	0.96	0.04	FALSE
19	GTEx	Breast Mammary Tissue (Male)	DHFR	0.29	0.07	enet	43	0.02	1.1e-01	-4.96	5.2	1.7e-07	0.07	0.18	0.49	FALSE
20	GTEx	Breast Mammary Tissue (Female)	DHFR	0.28	0.15	lasso	8	0.12	2.0e-04	-4.61	6.1	1.1e-09	0.04	0.18	0.70	FALSE
21	GTEx	Colon Sigmoid	DHFR	0.30	0.35	lasso	14	0.37	6.6e-14	-4.55	6.0	2.5e-09	0.05	0.98	0.02	FALSE
22	GTEx	Colon Transverse	PAPD4	0.22	0.05	lasso	9	0.10	1.5e-05	3.55	-5.7	1.6e-08	0.00	0.04	0.94	FALSE
23	GTEx	Colon Transverse	DHFR	0.24	0.17	lasso	8	0.23	3.0e-11	-4.55	5.9	2.7e-09	0.03	0.97	0.03	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	DHFR	0.28	0.25	lasso	5	0.21	4.5e-08	4.75	5.5	4.4e-08	0.02	0.02	0.98	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	CTD-2037K23.2	0.21	0.03	enet	18	0.05	6.5e-03	5.46	6.9	3.8e-12	-0.17	0.26	0.05	FALSE
26	GTEx	Esophagus Mucosa	DHFR	0.15	0.08	enet	12	0.10	6.0e-07	-4.25	5.2	2.1e-07	0.05	0.34	0.66	FALSE
27	GTEx	Esophagus Muscularis	PAPD4	0.10	0.06	lasso	3	0.06	1.9e-04	8.56	-8.7	4.6e-18	-0.01	0.00	1.00	TRUE
28	GTEx	Esophagus Muscularis	DHFR	0.34	0.22	enet	34	0.38	6.3e-24	4.75	7.2	8.4e-13	0.06	0.04	0.96	FALSE
29	GTEx	Esophagus Muscularis	CTD-2037K23.2	0.13	0.08	lasso	3	0.06	8.8e-05	5.59	5.8	5.7e-09	-0.11	0.92	0.01	FALSE
30	GTEx	Heart Atrial Appendage	DHFR	0.38	0.20	enet	60	0.30	6.0e-14	-4.23	6.1	1.2e-09	0.06	0.98	0.02	FALSE
31	GTEx	Heart Left Ventricle	DHFR	0.26	0.13	lasso	8	0.24	6.3e-13	-4.61	5.9	3.0e-09	0.04	0.95	0.05	FALSE
32	GTEx	Lung	DHFR	0.13	0.03	enet	54	0.05	8.2e-05	6.68	5.8	5.0e-09	0.03	0.02	0.98	FALSE
33	GTEx	Muscle Skeletal	DHFR	0.37	0.42	enet	51	0.54	1.7e-62	-4.61	6.5	7.7e-11	0.05	1.00	0.00	FALSE
34	GTEx	Nerve Tibial	SCAMP1	0.07	0.07	lasso	2	0.07	1.4e-05	5.65	5.3	1.3e-07	-0.05	0.56	0.04	FALSE
35	GTEx	Nerve Tibial	PAPD4	0.11	0.09	lasso	7	0.07	8.1e-06	5.71	-5.7	1.1e-08	0.00	0.81	0.14	FALSE
36	GTEx	Nerve Tibial	DHFR	0.36	0.25	enet	28	0.27	2.3e-19	6.68	6.1	1.3e-09	0.03	0.02	0.98	FALSE
37	GTEx	Ovary	DHFR	0.28	0.06	lasso	8	0.03	5.5e-02	6.44	5.3	9.6e-08	0.02	0.04	0.56	FALSE
38	GTEx	Pituitary	LHFPL2	0.38	0.02	lasso	9	0.04	4.0e-02	2.61	-9.1	9.5e-20	0.50	0.04	0.49	FALSE
39	GTEx	Pituitary	DHFR	0.35	0.11	enet	45	0.17	5.5e-05	-1.96	5.5	3.9e-08	0.09	0.15	0.70	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	DHFR	0.12	0.02	lasso	16	0.07	7.4e-05	-4.55	5.7	9.7e-09	0.05	0.40	0.35	FALSE
41	GTEx	Skin Sun Exposed Lower leg	DHFR	0.13	0.05	enet	19	0.10	1.8e-08	7.00	6.4	1.5e-10	0.03	0.01	0.99	FALSE
42	GTEx	Spleen	DHFR	0.47	0.11	lasso	10	0.18	2.2e-05	6.44	5.9	3.2e-09	0.05	0.04	0.93	FALSE
43	GTEx	Stomach	ARSB	0.19	0.01	lasso	7	0.04	6.6e-03	-4.21	-7.0	3.4e-12	0.13	0.14	0.09	FALSE
44	GTEx	Testis	LHFPL2	0.18	-0.01	enet	21	0.10	2.1e-05	3.21	6.1	1.3e-09	-0.26	0.10	0.16	FALSE
45	GTEx	Thyroid	ZFYVE16	0.16	0.07	lasso	6	0.04	2.6e-04	-5.52	-6.1	1.4e-09	-0.04	0.62	0.04	FALSE
46	METSIM	Adipose	AP3B1	0.07	0.01	blup	556	0.02	2.4e-04	4.95	-6.2	6.9e-10	0.54	0.09	0.82	FALSE
47	METSIM	Adipose	DHFR	0.26	0.16	bslmm	498	0.21	9.0e-31	-4.66	6.0	2.1e-09	0.06	1.00	0.00	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	BHMT	0.17	0.18	bslmm	401	0.21	3.0e-26	5.07	-5.7	1.3e-08	-0.02	0.95	0.05	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	DHFR	0.65	0.53	bslmm	482	0.79	6.7e-166	4.75	6.5	9.3e-11	0.05	1.00	0.00	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	CTD-2037K23.2	0.07	0.06	lasso	3	0.06	8.1e-08	5.46	5.4	6.5e-08	-0.10	1.00	0.00	FALSE
51	YFS	Blood	AP3B1	0.25	0.22	lasso	9	0.23	2.6e-74	5.37	-5.6	1.8e-08	0.30	1.00	0.00	FALSE
52	YFS	Blood	CMYA5	0.02	0.00	bslmm	498	0.00	1.5e-02	5.70	5.4	7.5e-08	0.03	0.10	0.13	FALSE
53	YFS	Blood	DHFR	0.02	0.00	blup	499	0.01	2.3e-04	-4.66	7.5	7.4e-14	0.08	0.15	0.67	FALSE
54	YFS	Blood	PAPD4	0.06	0.04	bslmm	455	0.04	4.8e-14	8.56	-6.7	1.7e-11	0.01	0.00	1.00	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	AP3B1	0.02	0.00	blup	126	0.01	1.8e-02	-13.65	-11.7	7.9e-32	0.85	0.02	0.88	TRUE
56	The Cancer Genome Atlas	Breast Invasive Carcinoma	DHFR	0.11	0.23	enet	15	0.24	1.7e-48	-4.66	5.2	1.7e-07	0.06	1.00	0.00	FALSE
57	The Cancer Genome Atlas	Breast Invasive Carcinoma	PAPD4	0.02	0.00	enet	12	0.01	1.0e-03	8.56	6.1	8.6e-10	0.03	0.01	0.90	FALSE
58	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	AP3B1	0.16	0.06	enet	18	0.09	2.2e-05	6.60	-8.8	2.0e-18	0.52	0.06	0.28	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	DHFR	0.51	0.23	blup	64	0.26	1.3e-08	-4.66	6.2	7.3e-10	0.02	0.57	0.40	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AP3B1	0.08	0.01	enet	20	0.02	9.7e-04	-13.62	-9.6	7.4e-22	0.60	0.01	0.88	TRUE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ARSB	0.12	0.06	blup	183	0.09	3.0e-10	3.75	-7.0	2.9e-12	0.01	0.96	0.04	TRUE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DHFR	0.20	0.18	enet	24	0.22	8.4e-24	7.07	7.2	6.4e-13	0.04	0.00	1.00	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DMGDH	0.03	0.02	lasso	5	0.02	3.1e-03	6.16	-5.3	1.2e-07	-0.05	0.01	0.92	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ARSB	0.23	0.03	blup	182	0.07	7.7e-05	2.89	-5.3	1.5e-07	0.01	0.39	0.08	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DHFR	0.13	0.04	enet	19	0.09	6.6e-06	-4.23	7.1	1.4e-12	0.06	0.02	0.94	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	BHMT	0.04	0.04	enet	9	0.02	2.4e-03	4.70	-6.0	2.5e-09	0.04	0.07	0.87	FALSE
67	The Cancer Genome Atlas	Brain Lower Grade Glioma	DHFR	0.32	0.29	enet	31	0.41	2.0e-50	-4.66	6.9	6.3e-12	0.05	1.00	0.00	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	AP3B1	0.05	0.03	lasso	3	0.04	4.4e-05	6.60	-6.7	2.2e-11	0.38	0.40	0.31	FALSE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	DHFR	0.11	0.19	blup	65	0.18	5.9e-21	-4.56	5.2	2.2e-07	0.04	1.00	0.00	FALSE
70	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	DHFR	0.18	0.09	blup	64	0.16	3.6e-07	-4.17	6.3	2.2e-10	0.04	0.13	0.86	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	DHFR	0.26	0.25	blup	65	0.27	3.4e-11	7.00	6.9	4.5e-12	0.04	0.00	1.00	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	AP3B1	0.05	0.02	blup	126	0.03	5.0e-04	7.11	-11.2	3.6e-29	0.81	0.02	0.92	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	BHMT2	0.15	0.05	blup	63	0.12	4.4e-12	-0.29	5.3	1.4e-07	0.04	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	DHFR	0.32	0.43	lasso	10	0.47	1.2e-55	-4.66	5.7	9.7e-09	0.05	1.00	0.00	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	ARSB	0.07	0.00	blup	182	0.03	1.4e-03	-1.47	-5.5	4.0e-08	0.01	0.04	0.15	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	DHFR	0.31	0.19	enet	22	0.33	7.2e-33	7.07	7.1	8.9e-13	0.04	0.00	1.00	FALSE