Hub : Genes

CMYA5

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0520	0.0225	0.0057	0.043	0.015	0.037	0.029	0.030	4.7e-07	0.002	2.7e-06	2.6e-05	2.3e-05
2	ROSMAP	Brain Pre-frontal Cortex	0.0678	0.0270	0.0047	0.005	0.002	-0.002	0.012	-0.001	5.9e-02	0.180	9.6e-01	9.9e-03	4.1e-01
3	YFS	Blood	0.0168	0.0076	0.0100	0.005	0.002	0.000	0.004	0.000	9.6e-03	0.074	4.4e-01	1.5e-02	2.1e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	2.4	-0.5	1.6	0.7
Bipolar Disorder or Schizophrenia	1.7	4.1	9.1	0.5	3.0	1.8
Depressed Affect (Nagel 2018)	1.0	2.1	5.4	-0.9	-2.3	0.4
Depression (Nagel 2018)	4.6	6.9	17.4	-1.8	-4.2	0.3
Intelligence (Savage-Jansen 2018)	0.2	0.6	0.9	-0.9	-0.5	-0.9
Neuroticism (Nagel 2018)	1.2	2.8	6.8	-1.1	-2.6	0.6
Schizophrenia (2018)	1.7	3.6	7.0	1.0	2.6	1.7
Schizophrenia vs Biploar Disorder	0.5	0.6	0.9	0.0	-1.0	-0.9
Worry (Nagel 2018)	0.2	0.4	0.6	-0.8	-0.8	-0.3
Alzheimer’s Disease (in mother)	0.8	1.0	2.0	-1.0	1.4	-0.1
Alzheimer’s Disease (in father)	2.0	2.2	5.8	-0.5	-2.4	-0.8
Alzheimer’s Disease (including proxy)	0.4	0.6	1.0	-1.0	-0.4	-0.7
Crohns Disease (2017)	1.4	3.0	4.6	2.1	1.0	1.8
Irritable Bowel Disease (IBD)	2.3	5.4	11.6	2.1	-0.2	3.4
Ulcerative Colitis (UC)	2.7	5.1	11.7	1.7	-0.8	3.4
Major Depression (MDD)	1.1	1.4	1.9	0.8	-1.3	1.4
Reaction Time	0.9	1.7	3.9	-0.9	0.7	-2.0
Verbal and Numeric Reasoning (VNR)	0.4	0.8	1.8	-1.3	0.8	-0.4
Breast Cancer	0.3	0.7	1.1	0.2	1.1	-0.9
Ovarian Cancer	0.6	0.8	2.2	0.4	-1.5	0.1
Prostate Cancer	0.3	0.4	1.0	-0.2	-0.0	1.0
Age at First Birth	0.2	0.3	1.0	1.0	-0.1	-0.1
Bipolar Disorder (2011)	1.0	1.0	2.7	1.6	0.4	0.2
Body Mass Index (BMI) (2010)	0.7	0.9	2.3	-1.5	-0.3	-0.6
Coronary Artery Disease (CAD)	1.0	1.1	2.1	1.4	0.1	1.1
Crohns Disease (2012)	0.3	0.4	0.9	0.9	-0.6	0.2
Mean Putamen Volume	0.0	0.1	0.1	0.4	0.1	0.0
Fasting Glucose	0.3	0.3	0.8	-0.9	0.5	0.1
HbA1C	2.0	2.2	5.3	2.3	-0.2	1.1
HDL Cholesterol	0.5	0.8	1.3	0.8	0.7	1.1
LDL Cholesterol	0.2	0.3	0.7	-0.9	0.1	0.1
Lupus	1.8	2.8	4.5	2.1	-1.9	0.4
Neuroticism (2016)	2.0	2.9	6.5	-1.5	-0.2	2.5
Primary Biliary Cirrhosis	2.4	3.4	5.1	1.5	1.7	2.3
Rheumatoid Arthritis	0.3	0.4	0.8	0.3	0.9	0.6
Schizophrenia (2014)	0.7	1.4	2.2	0.6	1.5	1.3
Triglycerides	0.4	0.7	1.4	0.3	-0.7	1.2
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	0.6	-0.2	1.5
Ulcerative Colitis	3.5	5.1	8.9	1.9	-1.7	3.0
Blood Eosinophil Count	0.1	0.5	0.7	0.9	-0.4	0.8
Blood Platelet Count	0.1	1.0	2.6	1.6	0.3	-0.4
Blood Red Count	0.1	1.2	2.8	0.7	-1.7	0.7
Blood White Count	0.3	2.0	2.3	1.5	-1.5	1.2
Heel T-Score	0.0	0.4	0.5	-0.7	-0.4	0.6
BMI	0.6	3.3	5.0	-1.7	-2.2	-1.5
Height	0.6	11.9	28.9	2.4	1.0	5.4
Waist Hip Ratio (WHR)	0.4	1.8	4.1	0.8	-2.0	0.8
Systolic Blood Pressure	0.3	1.4	2.1	0.3	-1.4	1.4
Smoking Status	0.5	1.2	3.2	1.8	0.2	0.6
Allergy or Eczema	0.4	1.1	1.7	-1.2	-1.3	-0.1
Cardiovascular Disease	0.5	1.5	3.2	0.1	-1.8	1.2
Hypothyroidism (self reported)	0.5	1.1	3.0	-0.1	-0.4	1.7
Respiratory disease	1.3	2.8	7.9	0.1	-2.8	0.7
Type 2 Diabetes (T2D) (2018)	0.8	1.5	4.0	0.7	0.1	2.0
Lung FEV1/FVC ratio	0.3	1.5	3.7	0.5	0.6	1.9
Lung FVC	0.8	3.9	6.4	-0.4	2.3	-2.5
Neuroticism	1.0	2.4	4.5	-2.1	-1.6	0.6
Chronotype (morning person)	0.3	0.8	0.8	0.9	-0.9	-0.9
Hair Pigment	0.1	1.8	4.4	-0.9	2.1	-0.5
Tanning	0.1	0.9	1.3	-1.1	-0.6	1.1
Hand grip strength (left)	0.3	0.8	1.9	0.3	0.7	1.4
Number of treatments/medications taken	0.2	0.3	0.5	0.0	-0.6	0.7
Average weekly spirits intake	0.4	0.5	0.9	0.9	-0.8	-0.2
Sensitivity / hurt feelings	1.0	1.8	3.8	-1.2	-1.9	-0.3
Frequency of depressed mood in last 2 weeks	2.9	4.1	6.9	-2.1	-2.6	-1.1
Hearing difficulty/problems: Yes	1.4	2.1	6.0	0.2	-2.5	-0.4
Relative age of first facial hair	1.7	3.4	8.0	0.7	1.3	2.8
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	3.2	-0.6	-1.8	-0.8
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.3	0.3	-0.6	-0.5
Ever had hysterectomy (womb removed)	0.9	1.1	2.6	-0.7	-1.6	-0.3
Systolic blood pressure, automated reading	0.2	0.6	1.5	-0.6	-1.2	0.0
Eye problems/disorders: Diabetes related eye disease	1.6	1.7	4.2	0.8	-0.5	2.0
Angina	1.1	1.5	3.6	1.9	0.7	0.5
Medication for hormone replacement therapy	0.7	0.8	1.1	0.2	-1.1	1.1
Vitamin and mineral supplements	0.2	0.3	0.6	0.5	0.3	-0.8
Supplements: Zinc	0.9	1.0	1.8	-1.4	-1.0	0.1
Medication: Co-codamol	1.1	1.3	3.7	0.1	-1.9	-0.0
Medication: Metformin	0.8	1.2	3.2	0.5	-0.1	1.8
Diabetes (father)	0.2	0.3	0.4	0.6	-0.5	0.5
Diabetes (mother)	0.7	0.9	2.3	0.2	-1.5	0.5
Severe depression (siblings)	0.1	0.2	0.2	-0.2	-0.5	0.5
Pack years adult smoking proportion	5.1	7.8	15.0	3.9	-2.1	2.0
Impedance of leg (right)	0.7	3.3	7.2	2.7	0.6	1.5
Leg fat-free mass (left)	0.4	1.9	3.4	-1.9	-0.9	1.2
Trunk fat percentage	0.1	0.2	0.5	0.5	0.0	0.7
Hand grip strength (right)	0.2	0.6	1.0	-0.1	0.8	1.0
Townsend deprivation index at recruitment	1.0	1.3	2.4	1.2	-1.5	0.5
Current tobacco smoking	0.5	0.8	2.2	0.3	-1.5	-0.4
Average weekly fortified wine intake	0.2	0.3	0.7	-0.2	-0.0	-0.9
Maternal smoking around birth	0.8	1.2	1.9	-1.4	-1.2	0.4
Fed-up feelings	1.0	1.8	3.9	-1.2	-2.0	0.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.5	2.0	4.0	-1.3	-2.0	0.5
Relative age voice broke	1.2	1.9	4.7	0.9	0.5	2.2
Taking other prescription medications	0.8	1.2	2.4	0.1	-1.1	1.5
Age when periods started (menarche)	1.4	3.5	6.8	2.6	1.9	-0.3
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.0	-1.0	-0.8	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	7.8	0.1	-2.8	-1.1
Tinnitus: Yes, but not now, but have in the past	0.7	0.8	1.1	0.8	-0.7	1.0
Qualifications: CSEs or equivalent	0.9	1.1	1.6	1.3	-1.1	-0.8
Serious illness, injury or assault to yourself	2.5	3.1	8.1	-1.0	-0.3	-2.9
High blood pressure	0.3	0.9	1.6	0.9	-1.3	0.6
Hayfever, allergic rhinitis or eczema	0.3	0.6	1.1	-0.3	-1.1	0.7
Multivitamins +/- minerals	0.2	0.2	0.4	0.3	0.6	0.3
Stomach or abdominal pain in last month	2.4	3.0	6.6	-1.4	-2.6	0.7
Supplements: Glucosamine	0.6	0.8	1.6	1.3	-0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	0.8	-0.4	-0.9	0.2
Medication: Atenolol	1.3	1.6	2.1	0.9	1.3	1.4
Medication: Levothyroxine sodium	1.0	1.7	3.9	0.0	-1.1	2.0
Sitting height	0.6	3.9	9.1	1.5	0.6	3.0
Chronic bronchitis/emphysema (father)	0.1	0.2	0.4	0.3	-0.1	0.6
High blood pressure (mother)	1.2	1.7	3.4	-1.8	-1.1	-0.8
Body mass index (BMI)	0.4	1.6	2.7	-1.6	-1.4	-0.6
Impedance of leg (left)	0.8	3.9	8.8	3.0	0.9	1.4
Leg predicted mass (left)	0.4	1.9	3.3	-1.8	-1.0	1.2
Trunk fat mass	0.1	0.4	1.0	0.1	-0.5	1.0
Waist circumference	0.6	2.3	6.5	-0.6	-2.6	0.1
Number of incorrect matches in round	0.9	1.5	4.3	-0.3	2.1	0.1
Past tobacco smoking	0.4	0.7	1.9	-1.4	0.3	-0.5
Alcohol usually taken with meals	0.3	0.5	1.4	0.0	1.2	-0.2
Nervous feelings	0.6	1.2	3.2	-1.8	-0.3	-0.5
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.5	2.8	-1.7	-1.2	-0.4
Hearing difficulty/problems with background noise	0.9	1.4	3.0	-0.6	-1.7	0.9
Hair/balding pattern: Pattern 2	1.7	2.2	3.7	-1.2	-1.2	-1.9
Had menopause	0.3	0.4	0.8	-0.2	0.9	-0.5
Had other major operations	1.9	2.3	4.4	0.0	-2.1	-1.6
Forced vital capacity (FVC)	0.2	0.9	2.8	-0.1	1.7	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	3.7	-0.8	-1.9	-1.1
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.7	-1.3	-1.0	0.2
Qualifications: None of the above	1.4	3.1	5.9	1.4	-2.4	-1.2
Financial difficulties in last 2 years	1.2	1.6	3.4	-0.8	-1.9	-0.7
Mouth/teeth dental problems	0.5	0.7	1.4	-1.2	0.9	0.0
Heart attack	1.3	1.7	4.7	2.2	0.5	0.2
Allergy	0.4	0.8	1.6	-0.4	1.3	-0.9
Pain all over the body in last month	0.2	0.3	0.4	-0.2	0.6	0.6
Diabetes (self-reported)	0.4	0.6	1.3	0.6	-0.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-0.3	-0.4	1.6
Medication: Ramipril	0.4	0.5	1.6	-0.2	0.0	1.3
Medication: Simvastatin	0.2	0.3	0.7	0.4	-0.9	-0.1
Fluid intelligence score	0.2	0.4	0.9	-1.0	0.2	0.4
Illnesses of siblings	0.6	0.9	2.2	0.5	0.2	-1.5
Neuroticism score	1.8	3.7	6.9	-2.6	-1.9	0.7
Weight	0.3	1.4	2.1	-1.0	-1.5	1.1
Impedance of arm (right)	1.0	4.7	6.7	2.6	1.9	2.0
Arm fat percentage (right)	0.1	0.4	0.8	-0.6	-0.9	0.2
Trunk fat-free mass	0.3	1.9	2.7	-1.6	-1.6	0.7
Hip circumference	0.4	1.6	3.9	-0.7	-2.0	0.7
Time employed in main current job	0.6	0.7	2.0	-0.1	-0.5	1.4
Alcohol intake versus 10 years previously	1.1	1.6	3.0	1.7	0.2	1.3
Father’s age at death	0.7	1.0	1.8	1.3	-0.2	1.1
Worrier / anxious feelings	0.9	1.7	4.7	-2.2	0.5	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.4	1.1	-1.0	-0.1	0.3
Falls in the last year	1.3	1.7	4.5	-0.9	-0.0	-2.1
Hair/balding pattern: Pattern 3	0.2	0.3	0.5	0.5	0.7	0.2
Number of live births	0.1	0.2	0.4	-0.3	0.7	-0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	3.5	-0.4	1.9	0.4
Pulse rate	0.5	0.9	1.8	0.5	-0.7	1.4
Happiness	1.9	2.3	4.1	-2.0	-0.3	-1.7
Noisy workplace	0.7	0.9	1.4	-1.2	1.0	0.5
Qualifications: A levels/AS levels or equivalent	0.4	1.0	2.5	-0.7	1.6	-0.1
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.3	3.8	0.2	-0.4	-2.0
Mouth/teeth dental problems: Dentures	0.2	0.4	0.5	0.7	-0.5	-0.6
Asthma	1.1	2.1	5.8	0.2	-2.4	0.7
Medication: Ibuprofen (e.g. Nurofen)	4.1	5.2	13.9	-3.7	-1.1	-0.7
Medication: Cholesterol lowering	2.8	4.3	8.5	2.0	-0.5	2.9
Depression (self-reported)	0.6	0.8	1.2	0.9	-0.6	1.1
Medication: Lansoprazole	1.6	1.9	4.0	1.1	-2.0	0.7
Prospective memory result	0.9	1.1	2.2	-0.4	-0.9	-1.5
Lung cancer (father)	0.9	1.0	2.2	-1.5	-0.5	-0.8
Illnesses of mother	0.4	0.5	1.4	0.4	1.2	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	4.8	-0.7	2.2	-0.3
Pulse wave Arterial Stiffness index	2.6	3.0	6.8	1.5	0.0	2.6
Impedance of arm (left)	1.4	6.7	7.5	2.7	2.3	2.6
Arm fat mass (right)	0.2	0.7	1.0	-1.0	-1.0	0.3
Trunk predicted mass	0.3	1.9	2.7	-1.6	-1.6	0.7
Standing height	0.6	5.8	15.7	1.3	0.1	4.0
Length of working week for main job	3.0	3.3	9.4	-0.2	-0.8	3.1
Exposure to tobacco smoke at home	0.2	0.3	0.7	0.0	0.9	-0.2
Breastfed as a baby	0.1	0.1	0.2	0.4	-0.0	-0.4
Tense / ‘highly strung’	0.3	0.6	1.2	-0.7	-1.1	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	1.8	1.3	-0.9	0.9
Hair/balding pattern: Pattern 4	0.0	0.1	0.1	-0.2	0.2	-0.4
Birth weight of first child	0.6	1.1	2.9	-0.5	0.3	-1.7
Peak expiratory flow (PEF)	0.0	0.1	0.2	-0.0	-0.5	-0.0
Pulse wave reflection index	0.7	0.8	1.2	0.4	1.1	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.7	0.5	-0.7	-1.3
Loud music exposure frequency	1.2	1.3	3.6	-0.2	-0.5	-1.9
Qualifications: O levels/GCSEs or equivalent	1.7	2.7	6.3	-0.2	2.5	-1.3
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	0.5	-0.4	-0.7	0.7
Blood clot in the leg (DVT)	0.5	0.7	1.2	0.9	0.1	1.1
Medication: Paracetamol	0.6	1.0	2.2	-1.5	-0.2	-0.9
Headache pain in last month	0.7	1.2	2.8	-1.7	-0.9	0.4
Medication for cholesterol, blood pressure or diabetes	1.5	2.5	3.9	-2.0	0.3	-1.9
Glaucoma (self-reported)	0.5	0.6	1.3	-0.5	0.3	-1.1
Gout (self-reported)	0.4	0.6	1.4	1.2	-0.3	0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.7	4.6	0.5	-0.6	2.1
Medication: Amlodipine	0.0	0.1	0.1	0.1	-0.3	0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.9	0.4	-1.4	0.5
Birth weight	0.1	0.2	0.7	-0.1	0.2	-0.8
Chronic bronchitis/emphysema (mother)	1.1	1.3	2.4	1.5	-0.8	0.9
High blood pressure (siblings)	0.1	0.1	0.4	-0.3	-0.0	0.6
Forced vital capacity (FVC), Best measure	0.5	1.7	3.9	-0.6	2.0	-1.0
Body fat percentage	0.1	0.3	0.6	0.1	-0.8	0.5
Leg fat percentage (right)	0.2	0.9	2.6	-0.1	-1.6	0.3
Arm fat-free mass (right)	0.4	1.9	2.7	-1.6	-1.6	0.5
Exposure to tobacco smoke outside home	0.3	0.3	0.8	0.9	0.4	-0.2
Comparative body size at age 10	1.2	3.3	4.8	-2.1	-0.8	-2.2
Number of full brothers	0.6	0.8	1.5	1.2	-0.7	-0.5
Worry too long after embarrassment	1.5	2.5	5.4	-2.3	-0.9	1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	11.8	0.9	-3.4	0.8
Wheeze or whistling in the chest in last year	1.7	3.0	7.8	0.8	-2.8	0.8
Number of children fathered	0.2	0.2	0.3	0.5	-0.5	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	3.1	-0.8	1.8	0.7
Age at first live birth	1.4	2.4	5.3	0.4	2.3	1.3
Pulse wave peak to peak time	1.8	2.2	5.1	-1.2	-0.1	-2.3
Health satisfaction	0.7	0.8	2.4	-1.5	0.1	-0.4
Shortness of breath walking on level ground	0.3	0.4	0.8	0.5	-0.9	-0.5
Qualifications: College or University degree	1.5	4.7	9.8	-3.1	2.0	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.5	-1.2	-0.1	0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.4	-1.2	0.5
Emphysema/chronic bronchitis	0.6	0.7	1.9	1.4	-0.4	-0.0
Medication for pain relief, constipation, heartburn	0.8	1.3	1.9	1.0	1.0	-1.4
Neck or shoulder pain in last month	1.2	1.7	2.0	-1.4	-1.2	-1.3
Medication: Blood pressure	1.7	2.9	4.7	2.2	0.1	2.0
Angina (self-reported)	1.5	1.9	4.0	2.0	0.7	1.1
Migraine (self-reported)	0.9	1.1	3.0	-1.7	-0.3	-0.3
Medication: Ibuprofen	4.0	4.8	10.8	-3.3	-1.5	-1.1
Medication: Allopurinol	0.2	0.3	0.5	0.7	-0.3	0.5
Medication: Omeprazole	0.3	0.3	1.0	0.0	1.0	-0.0
Medication: Seretide 50 evohaler	0.7	0.8	1.1	1.0	-0.9	0.8
Mean time to correctly identify matches	1.1	2.2	4.9	-1.3	0.1	-2.2
Heart disease (mother)	1.4	1.7	4.1	0.4	-2.0	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.0	-0.4	-0.4	-1.0
Whole body fat mass	0.1	0.4	0.9	-0.2	-0.9	0.7
Leg fat mass (right)	0.3	1.3	2.1	-0.7	-1.4	1.2
Arm predicted mass (right)	0.3	1.8	2.6	-1.6	-1.6	0.4
Pulse rate, automated reading	0.1	0.2	0.4	-0.3	-0.6	-0.1
Alcohol intake frequency.	0.0	0.0	0.0	-0.1	-0.2	-0.2
Comparative height size at age 10	0.3	1.8	3.3	-0.0	-1.4	1.8
Number of full sisters	0.6	0.7	2.0	-0.3	1.4	-0.1
Suffer from ‘nerves’	0.4	0.7	2.1	-0.1	-1.4	0.0
Overall health rating	0.7	1.5	3.0	-1.7	-1.2	-0.1
Chest pain or discomfort	1.6	2.3	6.4	0.6	-2.5	0.1
Had major operations	0.8	0.9	1.8	1.4	-0.3	0.9
Age at last live birth	0.3	0.5	1.3	-0.3	1.1	0.3
Family relationship satisfaction	0.4	0.5	1.1	0.3	-1.0	0.7
Leg pain on walking	0.5	0.6	1.7	-1.3	0.2	-0.4
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.1	0.4	0.1	-0.3
Commuting to job workplace: Car/motor vehicle	1.5	1.8	2.6	-1.4	-0.9	-1.6
Illness, injury, bereavement, stress in last 2 years	2.5	3.1	5.8	0.3	1.8	2.4
Medication: Aspirin	1.6	2.1	4.1	1.2	-0.9	2.0
Supplements: Vitamin C	0.8	1.0	1.9	-1.4	0.2	-1.0
Knee pain experienced in last month	2.3	3.5	7.8	-1.5	-0.8	-2.8
Hypertension (Self-reported)	0.2	0.4	0.9	0.5	-1.0	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.3	0.3	0.4	0.5
Illnesses of father: Heart disease	1.1	1.5	2.7	1.1	0.9	1.6
Illnesses of siblings: Diabetes	1.3	1.7	3.0	-1.0	-1.0	1.7
Smoking status: Previous	0.6	0.9	1.5	1.2	0.4	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	2.1	-1.0	-0.1	1.4
Whole body fat-free mass	0.3	2.0	3.2	-1.8	-1.4	0.8
Leg fat-free mass (right)	0.3	1.6	2.8	-1.7	-0.9	1.2
Arm fat percentage (left)	0.1	0.3	0.6	-0.5	-0.7	0.3
Average weekly red wine intake	0.7	1.0	2.4	-0.3	-1.6	-0.6
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.4	-1.0	0.6	-1.2
Mood swings	0.9	1.5	2.0	-1.4	-1.3	1.0
Loneliness, isolation	3.8	5.3	11.6	-1.6	-3.4	-1.3
Long-standing illness, disability or infirmity	0.6	1.0	1.7	0.6	-1.3	0.9
Ever had bowel cancer screening	3.4	3.9	7.9	-1.2	-2.8	-1.6
Diabetes diagnosed by doctor	0.9	1.4	3.4	0.8	-0.5	1.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.7	1.3	0.8	-1.1	0.4
Friendships satisfaction	0.0	0.0	0.0	-0.2	-0.1	0.2
Qualifications: nursing, teaching	0.8	1.3	2.1	-1.4	0.9	1.0
Commuting to job workplace: Walk	0.6	0.7	1.7	1.3	0.5	0.3
Eye problems/disorders: Cataract	0.4	0.5	0.9	-0.6	-0.3	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	2.1	-0.8	1.0	-1.5
Medication for cholesterol	0.1	0.2	0.3	-0.2	0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.6	0.3	-0.1
Back pain experienced in last month	1.3	1.9	4.1	-1.1	-2.0	0.5
Mineral and other dietary supplements	0.5	0.6	1.2	-1.1	-0.3	-0.8
Breast cancer (self-reported)	0.1	0.1	0.2	0.3	0.4	0.4
Asthma (self-reported)	1.3	2.6	7.2	0.1	-2.7	0.8
Osteoporosis (self-reported)	1.5	1.9	5.1	0.7	-0.2	-2.3
Osteoarthritis (self-reported)	0.4	0.5	0.8	0.2	0.9	-0.8
Medication: Aspirin	1.8	2.3	3.8	1.6	-0.8	2.0
Medication: Gliclazide	0.6	0.7	1.2	0.0	-1.0	1.1
Illnesses of father: None of the above (group 1)	1.5	1.8	4.4	-0.7	0.8	-2.1
Smoking status: Current	0.2	0.2	0.7	0.1	-0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.7	1.5	-0.8	0.2	-1.2
Whole body water mass	0.3	1.9	3.1	-1.8	-1.5	0.6
Leg predicted mass (right)	0.3	1.7	2.9	-1.7	-0.9	1.2
Arm fat mass (left)	0.2	0.7	1.3	-1.1	-0.9	0.2
Number of self-reported non-cancer illnesses	0.4	0.7	1.7	0.5	-0.4	1.3
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-0.2	0.9	1.4
Miserableness	0.9	1.6	2.6	-0.2	-1.6	1.4
Guilty feelings	2.7	4.1	7.3	-2.7	-1.9	-1.1
Wears glasses or contact lenses	0.8	0.9	1.5	1.0	0.6	1.2
Ever taken oral contraceptive pill	0.8	0.9	2.0	1.4	-0.0	0.8
Hearing aid user	0.9	1.0	1.2	-0.9	1.1	0.9
Mother’s age at death	0.5	0.6	0.9	-0.8	-0.9	0.5
Financial situation satisfaction	1.4	1.8	4.3	-2.1	0.9	0.4
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.6	-1.9	0.5	2.1
Commuting to job workplace: Public transport	0.0	0.0	0.1	0.3	-0.1	0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.2	0.1	0.3	-0.4
Medication: Blood pressure	0.1	0.1	0.4	-0.6	0.0	-0.0
Pain type(s) experienced in last month: Hip pain	3.3	4.1	7.3	-1.7	-2.7	-1.5
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.4	0.7	1.0	1.2
High cholesterol (Self-reported)	0.9	1.5	2.2	1.4	-1.5	0.6
Medication: Bendroflumethiazide	1.2	1.8	3.0	-0.7	1.4	-1.7
Medication: Paracetamol	1.0	1.5	2.3	-1.4	0.5	-1.5
Medication: Lisinopril	0.7	0.9	1.0	-1.0	0.9	-1.0
Medication: Atorvastatin	0.9	1.1	1.5	1.2	-1.2	0.7
Illnesses of father: High blood pressure	0.1	0.1	0.2	-0.3	0.4	-0.3
Alcohol drinker status: Never	0.2	0.3	0.7	0.8	0.4	-0.2
Ever smoked	1.0	1.7	4.4	2.1	-0.6	-0.6
Basal metabolic rate	0.3	1.9	2.9	-1.7	-1.4	0.9
Leg fat percentage (left)	0.3	0.9	2.8	-0.0	-1.7	0.3
Arm fat-free mass (left)	0.4	2.0	3.1	-1.7	-1.8	0.2
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.4	0.2
Average weekly beer plus cider intake	0.3	0.5	0.9	0.6	0.4	-1.0
Irritability	1.0	1.6	3.8	0.1	-1.1	1.9
Risk taking	0.7	1.1	2.3	1.5	-1.0	-0.1
Ever had prostate specific antigen (PSA) test	0.7	0.8	1.3	-0.4	-1.0	1.1
Fractured/broken bones in last 5 years	0.7	0.9	1.5	0.7	1.2	-0.7
Age started oral contraceptive pill	1.5	1.9	2.6	-1.6	1.6	0.9
Diastolic blood pressure, automated reading	0.5	1.7	2.5	-1.6	-1.5	-0.6
Ever depressed for a whole week	0.4	0.5	1.5	-0.1	-1.2	0.4
Unable to work because of sickness or disability	0.4	0.5	0.8	0.5	-0.6	0.9
Commuting to job workplace: Cycle	1.6	2.0	3.7	0.2	1.5	1.9
Myopia	1.0	1.5	2.1	-1.2	-0.9	-1.4
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.4	-1.8	1.3	-0.7
Cholesterol lowering medication	0.5	0.8	1.3	0.4	-1.1	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.3	-0.3	1.1	0.5
Pain experienced in last month	2.2	3.7	6.9	2.6	1.7	1.1
Supplements: Calcium	0.6	0.6	1.5	-1.2	-0.5	0.2
Basal cell carcinoma (self-reported)	0.2	0.3	0.3	-0.5	0.5	-0.5
Heart attack/myocardial infarction (self-reported)	1.8	2.4	7.0	2.6	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	1.5	0.6	0.4	1.2
Heart disease (siblings)	1.6	2.0	5.6	0.6	-0.1	2.4
Alcohol drinker status: Previous	0.5	0.6	1.5	-1.2	-0.1	-0.5
Pack years of smoking	6.1	9.0	17.7	4.2	-2.1	2.1
Impedance of whole body	1.1	5.6	9.2	3.0	1.7	2.2
Leg fat mass (left)	0.3	1.2	1.9	-0.8	-1.4	1.0
Arm predicted mass (left)	0.5	2.4	3.9	-1.8	-2.0	0.1