Hub : Genes

ARHGAP18

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1280 0.0350 3.9e-05 0.069 0.050 0.042 0.059 0.061 8.1e-09 8.3e-07 6.5e-06 9.4e-08 6.3e-08
2 GTEx Nerve Tibial 0.2163 0.0552 3.6e-04 0.085 NA 0.136 NA 0.114 1.4e-06 NA 6.9e-10 NA 1.9e-08
3 TCGA Kidney Renal Papillary Cell Carcinoma 0.0880 0.0400 4.7e-03 0.111 0.018 0.056 NA 0.027 6.5e-07 3.2e-02 3.8e-04 NA 1.1e-02
4 TCGA Lung Squamous Cell Carcinoma 0.0565 0.0277 8.7e-03 0.005 0.001 0.023 NA 0.019 7.5e-02 2.6e-01 1.2e-03 NA 2.6e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 0.5 0.7 1.8 -1.3 0.7 -0.5 -0.6
Bipolar Disorder or Schizophrenia 0.4 1.0 1.7 -0.7 1.3 -0.0 -1.3
Depressed Affect (Nagel 2018) 1.3 2.8 5.5 -0.3 -0.9 -2.3 -2.2
Depression (Nagel 2018) 0.8 1.1 3.9 0.8 0.0 -0.3 -2.0
Intelligence (Savage-Jansen 2018) 0.1 0.2 0.4 0.3 -0.6 -0.6 -0.4
Neuroticism (Nagel 2018) 0.9 2.2 7.1 -0.7 -0.6 -2.7 -0.9
Schizophrenia (2018) 0.3 0.6 1.4 0.2 1.0 0.4 -1.2
Schizophrenia vs Biploar Disorder 0.4 0.6 2.2 1.5 0.3 -0.1 0.3
Worry (Nagel 2018) 0.4 0.9 3.2 -0.5 -0.4 -1.8 -0.1
Alzheimer’s Disease (in mother) 0.3 0.3 0.9 -0.9 0.0 0.3 -0.6
Alzheimer’s Disease (in father) 1.6 1.7 4.5 -0.2 -1.0 -2.1 -1.1
Alzheimer’s Disease (including proxy) 0.4 0.6 1.2 -0.1 0.2 -1.1 -1.0
Crohns Disease (2017) 0.3 0.7 1.6 0.2 -0.6 -1.2 1.0
Irritable Bowel Disease (IBD) 0.3 0.7 2.4 -0.3 0.0 -0.5 1.5
Ulcerative Colitis (UC) 0.4 0.8 2.7 -0.8 0.4 0.0 1.6
Major Depression (MDD) 2.1 2.6 5.6 -0.2 -0.3 -2.4 -2.1
Reaction Time 1.0 1.9 5.7 0.3 2.4 1.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.5 -0.1 -0.8 -1.2 -0.6
Breast Cancer 1.0 2.5 8.1 1.4 -0.1 2.8 -0.3
Ovarian Cancer 0.2 0.3 0.6 -0.1 0.7 0.8 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.6 0.9 1.4 -1.2 -1.2 -0.0 0.9
Bipolar Disorder (2011) 2.0 1.9 2.5 -1.6 -1.4 -0.8 -1.6
Body Mass Index (BMI) (2010) 0.4 0.5 0.8 -0.7 -0.9 -0.1 -0.9
Coronary Artery Disease (CAD) 2.0 2.4 3.8 -0.2 -2.0 -1.8 -1.6
Crohns Disease (2012) 1.0 1.6 2.2 0.8 -1.5 -1.4 1.3
Mean Putamen Volume 2.1 2.4 5.2 1.2 1.6 -0.6 -2.3
Fasting Glucose 0.6 0.8 1.5 0.8 -0.8 -0.3 -1.2
HbA1C 2.3 2.6 5.3 1.6 -1.4 -2.3 -0.8
HDL Cholesterol 0.4 0.7 1.7 -0.2 1.3 0.9 -0.0
LDL Cholesterol 1.1 1.7 4.2 -1.0 2.1 0.8 0.9
Lupus 1.7 2.6 6.1 -0.8 1.9 2.5 0.2
Neuroticism (2016) 0.8 1.1 4.4 -0.0 0.1 -2.1 -0.2
Primary Biliary Cirrhosis 1.6 2.3 7.9 -2.8 0.4 0.9 0.5
Rheumatoid Arthritis 1.4 1.9 6.3 0.4 2.5 -0.2 -1.1
Schizophrenia (2014) 0.7 1.4 2.6 0.8 1.4 0.7 -1.6
Triglycerides 0.2 0.3 0.8 0.9 -0.5 -0.5 -0.0
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.2 0.2 1.2 0.0 -1.5
Ulcerative Colitis 0.5 0.7 1.1 -0.9 -1.1 -0.6 0.8
Blood Eosinophil Count 0.4 3.4 9.2 -3.0 1.2 1.1 -1.3
Blood Platelet Count 0.2 2.0 7.1 2.7 0.6 0.4 0.8
Blood Red Count 0.3 2.7 6.2 -2.5 1.8 1.0 0.6
Blood White Count 0.1 1.1 4.0 0.1 -0.4 -0.3 -2.0
Heel T-Score 0.6 5.1 10.9 -1.8 3.3 2.4 -0.5
BMI 0.6 3.2 8.8 -3.0 1.0 1.6 -0.7
Height 0.5 9.1 32.9 -5.7 -1.4 -0.9 0.8
Waist Hip Ratio (WHR) 0.2 0.8 2.9 -0.3 0.2 0.5 -1.7
Systolic Blood Pressure 0.6 3.0 7.6 1.9 -2.8 -1.0 0.0
Smoking Status 1.5 3.5 7.6 -0.2 -1.1 -2.8 -2.3
Allergy or Eczema 0.2 0.6 1.6 0.6 0.2 1.3 0.5
Cardiovascular Disease 0.3 0.9 3.2 0.3 0.2 -0.4 -1.8
Hypothyroidism (self reported) 0.4 1.0 2.2 -1.5 1.2 0.4 -0.6
Respiratory disease 0.6 1.3 2.6 -1.4 -0.3 1.6 0.8
Type 2 Diabetes (T2D) (2018) 1.7 3.2 5.3 -1.4 -1.8 -1.4 -2.3
Lung FEV1/FVC ratio 0.3 1.7 3.4 1.1 1.9 -0.5 -1.4
Lung FVC 0.3 1.3 3.5 1.3 0.5 -0.2 1.9
Neuroticism 0.5 1.2 3.9 -0.2 0.1 -2.0 -0.9
Chronotype (morning person) 0.8 1.9 4.8 1.6 -2.2 0.5 -0.0
Hair Pigment 0.0 0.8 2.2 1.5 -0.1 0.9 -0.5
Tanning 0.1 1.6 2.9 -1.6 0.2 -1.7 -1.0
Hand grip strength (left) 0.4 1.2 2.3 -0.6 -1.0 -1.5 1.0
Number of treatments/medications taken 1.1 2.1 3.4 -1.2 1.5 -1.1 -1.8
Average weekly spirits intake 1.1 1.4 2.1 1.3 1.4 1.3 -0.1
Sensitivity / hurt feelings 1.2 2.0 6.9 -0.0 0.4 -2.6 1.0
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.6 -0.2 0.4 -1.1 -1.3
Hearing difficulty/problems: Yes 1.7 2.6 8.9 -0.8 3.0 -0.6 -0.8
Relative age of first facial hair 0.5 1.0 3.9 -0.0 2.0 -0.1 0.5
Other serious medical condition/disability diagnosed by doctor 1.3 1.7 5.6 0.4 2.4 0.0 -1.1
Ever used hormone-replacement therapy (HRT) 1.2 1.5 3.7 0.4 1.5 0.2 -1.9
Ever had hysterectomy (womb removed) 2.5 2.8 9.5 -1.2 -0.3 0.5 -3.1
Systolic blood pressure, automated reading 0.4 1.0 2.2 0.7 -1.5 0.9 0.8
Eye problems/disorders: Diabetes related eye disease 0.6 0.6 2.0 -0.4 -0.5 -1.4 -0.2
Angina 1.0 1.4 4.2 -0.7 0.1 -0.9 -2.0
Medication for hormone replacement therapy 0.8 0.9 2.9 0.8 -0.2 0.3 -1.7
Vitamin and mineral supplements 0.2 0.2 0.5 -0.7 -0.3 -0.6 0.1
Supplements: Zinc 0.8 0.9 1.8 -1.3 0.3 1.3 -0.0
Medication: Co-codamol 2.0 2.3 6.5 -1.5 -0.3 -0.4 -2.5
Medication: Metformin 0.7 1.0 3.2 -1.8 0.1 -0.8 -0.3
Diabetes (father) 0.8 1.0 1.8 -1.3 -0.5 0.4 1.3
Diabetes (mother) 0.2 0.2 0.6 -0.4 -0.8 -0.4 -0.1
Severe depression (siblings) 0.8 0.9 1.3 -0.7 -0.8 -1.1 -1.0
Pack years adult smoking proportion 0.8 1.2 2.8 0.3 -1.3 -0.5 -1.7
Impedance of leg (right) 0.1 0.3 0.7 0.8 -0.2 -0.5 -0.3
Leg fat-free mass (left) 0.4 2.1 8.0 -2.8 -0.1 0.2 -0.7
Trunk fat percentage 1.0 4.1 11.9 -3.5 0.7 0.2 -2.0
Hand grip strength (right) 0.7 2.0 4.6 -0.3 -1.8 -2.1 0.5
Townsend deprivation index at recruitment 0.5 0.7 1.2 -1.1 1.0 0.8 -0.3
Current tobacco smoking 1.1 1.8 3.6 -0.4 -0.5 -1.9 -1.8
Average weekly fortified wine intake 0.6 0.7 1.5 1.2 -0.3 1.1 0.4
Maternal smoking around birth 0.7 1.0 3.7 0.3 -1.9 -0.4 -0.3
Fed-up feelings 1.2 2.2 4.4 -0.1 -1.4 -2.1 -1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 1.3 1.7 6.6 0.2 -0.5 -0.1 -2.6
Relative age voice broke 0.6 0.9 3.1 0.4 -0.2 0.5 1.8
Taking other prescription medications 1.7 2.7 5.6 -1.7 2.4 -0.4 -1.5
Age when periods started (menarche) 1.1 2.5 8.7 1.0 0.1 -3.0 -0.7
Bilateral oophorectomy (both ovaries removed) 1.6 1.8 2.8 -1.6 -1.1 -0.9 -1.7
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.2 0.5 -0.7 0.2 -0.4 -0.1
Tinnitus: Yes, but not now, but have in the past 2.4 2.6 3.6 1.3 1.6 -1.9 -1.6
Qualifications: CSEs or equivalent 0.7 1.0 2.0 -1.1 -0.6 -0.6 -1.4
Serious illness, injury or assault to yourself 1.8 2.2 4.6 1.5 -1.0 -2.1 -1.0
High blood pressure 0.3 0.9 1.8 -0.8 0.3 -1.0 -1.3
Hayfever, allergic rhinitis or eczema 0.5 1.1 3.3 1.8 -0.4 0.9 0.1
Multivitamins +/- minerals 1.1 1.4 4.2 0.6 -0.9 0.5 -2.0
Stomach or abdominal pain in last month 0.4 0.6 1.4 -0.4 1.2 -0.7 -0.3
Supplements: Glucosamine 0.5 0.7 1.9 0.3 -1.4 -0.1 -0.9
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.6 0.2 0.8 -0.3 0.0
Medication: Atenolol 0.7 0.9 1.5 -1.1 0.7 -1.2 -0.6
Medication: Levothyroxine sodium 0.8 1.3 3.4 -1.8 1.3 -0.4 0.3
Sitting height 0.2 1.1 2.2 -1.4 -1.5 -0.4 0.5
Chronic bronchitis/emphysema (father) 0.8 1.0 2.4 -0.6 -1.6 0.6 -0.9
High blood pressure (mother) 0.5 0.7 1.7 -0.1 -1.3 -0.4 0.8
Body mass index (BMI) 0.6 2.8 6.4 -2.5 0.8 1.4 -1.4
Impedance of leg (left) 0.0 0.1 0.2 -0.1 -0.1 -0.5 -0.1
Leg predicted mass (left) 0.4 2.1 7.9 -2.8 -0.1 0.3 -0.7
Trunk fat mass 1.1 4.9 15.2 -3.9 0.7 0.4 -1.9
Waist circumference 0.9 3.4 7.9 -2.8 0.3 1.3 -2.0
Number of incorrect matches in round 0.9 1.5 3.5 1.9 -0.7 0.7 -1.3
Past tobacco smoking 1.2 2.1 6.4 0.5 0.3 2.5 1.4
Alcohol usually taken with meals 0.1 0.2 0.7 0.3 0.9 0.2 0.1
Nervous feelings 0.3 0.6 2.1 -0.5 -0.1 -1.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.7 2.6 8.2 -1.1 1.0 -2.9 -0.4
Hearing difficulty/problems with background noise 2.4 3.8 7.0 -1.8 1.9 -1.1 -2.6
Hair/balding pattern: Pattern 2 0.8 1.0 2.8 -0.7 -1.7 -0.4 0.7
Had menopause 1.8 2.2 5.2 -1.2 2.3 1.2 -0.7
Had other major operations 0.8 0.9 2.4 0.8 0.6 -0.7 -1.5
Forced vital capacity (FVC) 0.4 1.6 3.2 -0.3 0.1 -1.7 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.0 -0.5 -0.3 -0.4 -1.4
Ever unenthusiastic/disinterested for a whole week 4.1 5.0 15.2 -0.9 -0.8 -3.9 -1.8
Qualifications: None of the above 0.2 0.5 0.8 -0.9 0.9 -0.5 -0.2
Financial difficulties in last 2 years 1.4 1.9 6.6 0.6 0.3 0.8 -2.6
Mouth/teeth dental problems 0.8 1.2 2.0 1.4 0.2 0.9 -1.4
Heart attack 1.5 1.9 4.6 -2.1 -0.4 -1.5 -0.8
Allergy 0.2 0.5 1.0 -1.0 -0.1 -0.5 -0.9
Pain all over the body in last month 1.8 2.0 7.1 -2.7 0.5 -0.5 -0.5
Diabetes (self-reported) 0.4 0.7 1.4 -0.3 -0.4 -1.1 -1.2
Hayfever/allergic rhinitis (self-reported) 0.1 0.2 0.4 -0.6 0.4 -0.1 0.3
Medication: Ramipril 0.4 0.5 1.3 -0.8 -0.0 -0.1 -1.1
Medication: Simvastatin 0.6 0.8 1.7 0.6 -0.6 -0.9 -1.3
Fluid intelligence score 0.1 0.2 0.5 0.5 -0.7 -0.1 0.2
Illnesses of siblings 0.8 1.2 2.0 0.5 -1.4 0.7 1.4
Neuroticism score 0.8 1.7 6.6 -0.5 -0.2 -2.6 -0.1
Weight 0.9 4.4 15.4 -3.9 0.5 1.0 -0.9
Impedance of arm (right) 0.3 1.3 2.3 1.5 -1.2 -1.1 -0.5
Arm fat percentage (right) 0.7 2.9 6.4 -2.5 0.7 0.8 -2.0
Trunk fat-free mass 0.4 2.3 8.4 -2.9 -0.2 0.7 0.5
Hip circumference 0.5 2.1 7.1 -2.7 0.4 1.1 -0.2
Time employed in main current job 0.6 0.7 1.4 0.9 -0.2 -1.2 -0.7
Alcohol intake versus 10 years previously 2.7 4.0 9.8 -3.1 1.1 -1.5 -1.7
Father’s age at death 1.7 2.3 5.2 1.1 1.6 -0.5 2.3
Worrier / anxious feelings 0.3 0.5 0.9 -0.6 -0.9 -0.5 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.7 1.1 2.0 -1.3 -0.4 -0.6 -1.4
Falls in the last year 1.3 1.8 5.1 -0.0 0.7 -1.2 -2.2
Hair/balding pattern: Pattern 3 1.1 1.6 3.7 0.0 1.5 1.9 0.5
Number of live births 0.5 0.8 2.6 1.6 0.3 -0.4 0.5
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.3 0.7 0.1 -1.8 1.5
Pulse rate 0.2 0.4 0.6 -0.6 0.8 0.3 0.7
Happiness 0.9 1.1 3.5 0.1 -0.6 -0.8 -1.9
Noisy workplace 0.4 0.4 1.3 0.3 -0.4 -1.2 -0.4
Qualifications: A levels/AS levels or equivalent 0.6 1.4 4.0 0.2 -0.7 1.0 2.0
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.8 0.0 -0.0 -0.9 -0.0
Mouth/teeth dental problems: Dentures 1.3 2.2 6.6 -2.6 -1.2 -0.9 -0.0
Asthma 0.5 1.0 2.0 -1.0 0.5 0.7 1.4
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 3.3 1.2 1.0 1.3 -1.8
Medication: Cholesterol lowering 0.7 1.0 3.2 0.4 -0.5 -0.7 -1.8
Depression (self-reported) 2.1 2.5 3.9 -1.2 2.0 -1.7 -1.4
Medication: Lansoprazole 0.8 0.9 2.1 -1.2 1.4 -0.3 -0.3
Prospective memory result 2.4 2.9 7.0 -2.6 1.7 1.4 -0.2
Lung cancer (father) 1.4 1.6 3.6 -0.4 -0.5 -1.5 -1.9
Illnesses of mother 0.1 0.1 0.4 0.6 0.1 -0.0 -0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.8 2.0 0.3 0.3 -1.1 1.4
Pulse wave Arterial Stiffness index 0.9 1.1 4.0 -2.0 0.5 0.1 0.4
Impedance of arm (left) 0.2 0.7 1.3 1.1 -0.8 -0.9 -0.3
Arm fat mass (right) 1.0 3.9 10.8 -3.3 0.6 0.9 -1.9
Trunk predicted mass 0.4 2.2 7.8 -2.8 -0.2 0.8 0.5
Standing height 0.3 3.3 10.7 -3.3 -1.1 -0.7 0.8
Length of working week for main job 1.8 2.0 3.7 -1.2 1.6 1.9 0.6
Exposure to tobacco smoke at home 0.4 0.4 0.7 -0.9 0.8 0.2 0.6
Breastfed as a baby 1.0 1.2 4.1 -0.0 0.0 -2.0 -0.8
Tense / ‘highly strung’ 0.9 1.6 5.5 -0.8 -0.4 -2.3 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.1 4.5 -1.9 -1.2 -1.7 -2.1
Hair/balding pattern: Pattern 4 0.6 1.5 4.2 0.1 -2.1 0.6 -1.2
Birth weight of first child 0.1 0.2 0.4 -0.4 -0.6 -0.2 -0.5
Peak expiratory flow (PEF) 0.9 2.0 6.2 0.4 -1.0 -2.5 0.9
Pulse wave reflection index 0.4 0.5 1.1 -1.0 -0.1 0.8 -0.4
Ever highly irritable/argumentative for 2 days 1.4 1.7 2.2 -1.5 -0.3 -1.4 -1.5
Loud music exposure frequency 0.4 0.4 0.8 0.6 0.6 -0.9 -0.3
Qualifications: O levels/GCSEs or equivalent 1.2 2.0 3.7 1.7 -1.9 0.6 -1.0
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 2.9 0.6 1.7 -0.7 -0.2
Blood clot in the leg (DVT) 0.1 0.2 0.4 -0.6 0.3 -0.5 -0.3
Medication: Paracetamol 0.2 0.3 0.6 0.7 0.5 0.8 0.1
Headache pain in last month 0.2 0.4 0.6 -0.7 -0.0 -0.7 0.8
Medication for cholesterol, blood pressure or diabetes 1.0 1.7 6.5 0.3 0.4 -0.0 2.5
Glaucoma (self-reported) 1.3 1.6 5.2 0.9 -0.4 -0.1 -2.3
Gout (self-reported) 2.4 3.3 7.0 0.2 -2.7 -1.4 -2.0
Hypothyroidism/myxoedema (self-reported) 0.8 1.5 3.8 -1.4 1.9 0.0 -0.5
Medication: Amlodipine 3.4 4.8 11.1 -0.8 -3.3 -1.1 -2.5
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.4 0.6 -0.1 0.2 0.1
Birth weight 0.2 0.3 1.1 -1.1 -0.0 0.2 0.4
Chronic bronchitis/emphysema (mother) 0.1 0.1 0.3 -0.2 -0.1 0.4 -0.6
High blood pressure (siblings) 1.3 1.8 4.4 -0.7 0.1 -1.6 -2.1
Forced vital capacity (FVC), Best measure 0.3 1.1 3.4 -0.4 -0.2 -1.0 1.9
Body fat percentage 1.1 4.3 12.2 -3.5 0.9 0.4 -2.0
Leg fat percentage (right) 1.1 4.1 9.6 -3.1 1.7 1.3 -1.6
Arm fat-free mass (right) 0.7 3.5 13.0 -3.6 0.3 0.8 -0.1
Exposure to tobacco smoke outside home 0.3 0.4 1.0 0.5 -0.2 -0.5 -1.0
Comparative body size at age 10 0.1 0.2 0.6 0.8 0.3 0.2 0.4
Number of full brothers 0.4 0.5 1.3 0.5 1.1 0.6 -0.2
Worry too long after embarrassment 0.6 1.0 1.5 -1.0 -0.9 -1.2 0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 2.0 2.6 4.9 -1.2 1.6 -2.2 -1.2
Wheeze or whistling in the chest in last year 0.6 1.0 1.8 -1.3 1.1 0.8 -0.7
Number of children fathered 0.2 0.3 0.6 0.8 -0.6 0.1 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 0.0 -0.6 0.1 0.9
Age at first live birth 0.6 1.0 3.1 1.8 0.8 0.6 -0.2
Pulse wave peak to peak time 0.8 0.9 3.3 1.8 -0.5 -0.2 -0.4
Health satisfaction 1.2 1.6 5.4 -0.0 -1.0 -0.3 -2.3
Shortness of breath walking on level ground 1.4 1.6 3.8 -0.3 1.3 1.0 1.9
Qualifications: College or University degree 0.3 1.0 3.3 -0.8 -1.8 -0.4 0.4
Eye problems/disorders: None of the above 0.2 0.2 0.5 -0.7 -0.1 0.5 0.2
Mouth/teeth dental problems: Loose teeth 1.0 1.2 1.8 -1.1 -1.3 -1.2 0.5
Emphysema/chronic bronchitis 0.1 0.2 0.5 -0.1 0.7 0.1 0.3
Medication for pain relief, constipation, heartburn 0.2 0.4 0.9 0.0 -1.0 0.7 0.5
Neck or shoulder pain in last month 0.4 0.5 0.8 -0.4 0.8 -0.9 -0.6
Medication: Blood pressure 0.9 1.5 3.2 -0.4 -1.6 -0.3 -1.8
Angina (self-reported) 1.1 1.5 4.6 -0.7 -0.0 -0.9 -2.1
Migraine (self-reported) 1.4 1.8 6.0 0.3 -0.4 1.0 2.4
Medication: Ibuprofen 0.9 1.0 1.8 0.5 1.3 0.6 -1.3
Medication: Allopurinol 1.4 1.9 3.0 0.8 -1.7 -1.2 -1.6
Medication: Omeprazole 0.5 0.6 1.2 -1.1 1.0 0.2 -0.5
Medication: Seretide 50 evohaler 2.3 2.7 7.1 0.2 2.7 1.8 0.7
Mean time to correctly identify matches 0.9 1.6 5.4 0.5 2.3 0.7 -0.7
Heart disease (mother) 2.9 3.5 5.6 -2.0 2.4 1.3 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.1 -0.4 1.0 -0.5 -1.0
Whole body fat mass 1.2 4.9 15.6 -4.0 0.5 0.4 -1.9
Leg fat mass (right) 1.2 4.7 12.2 -3.5 1.0 1.0 -2.1
Arm predicted mass (right) 0.6 3.0 11.3 -3.4 0.2 0.9 -0.2
Pulse rate, automated reading 0.1 0.4 1.2 -1.1 0.1 -0.3 0.4
Alcohol intake frequency. 0.4 0.9 3.1 -0.6 1.8 0.3 0.5
Comparative height size at age 10 1.2 6.5 20.0 -4.5 -0.9 0.5 2.2
Number of full sisters 1.4 1.7 4.1 0.7 0.1 -2.0 -1.4
Suffer from ‘nerves’ 1.4 2.3 4.8 -2.1 0.1 -2.2 -0.2
Overall health rating 1.0 2.2 7.8 -0.6 -0.7 0.2 -2.8
Chest pain or discomfort 3.1 4.5 6.6 -2.6 -0.9 -2.2 -2.4
Had major operations 1.8 2.2 4.0 0.5 -1.7 -2.0 -1.2
Age at last live birth 0.1 0.2 0.4 0.2 0.2 -0.6 0.5
Family relationship satisfaction 1.7 2.1 2.9 1.5 0.9 -1.7 -1.5
Leg pain on walking 0.5 0.7 1.8 -0.0 1.4 -0.6 -0.7
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.3 0.8 0.4 -2.3 -1.5
Commuting to job workplace: Car/motor vehicle 0.1 0.1 0.3 0.5 -0.2 -0.1 -0.3
Illness, injury, bereavement, stress in last 2 years 0.6 0.7 2.4 -0.4 -0.3 -0.3 1.6
Medication: Aspirin 1.3 1.7 4.8 -0.8 -1.1 -2.2 -0.4
Supplements: Vitamin C 0.7 0.8 2.5 0.0 0.9 -0.2 1.6
Knee pain experienced in last month 0.2 0.3 1.3 -0.2 -0.0 -0.3 -1.1
Hypertension (Self-reported) 0.4 1.1 2.1 -1.1 -0.2 -1.1 -1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 4.2 0.2 2.1 0.8 0.4
Illnesses of father: Heart disease 0.6 0.8 2.0 -1.0 0.4 0.3 1.4
Illnesses of siblings: Diabetes 1.2 1.5 4.2 -0.3 2.0 -0.3 -1.3
Smoking status: Previous 0.6 0.9 2.4 -0.6 -0.1 -1.5 -0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.2 0.4 0.6 -0.8 -0.7 -0.7 -0.3
Whole body fat-free mass 0.4 2.4 9.4 -3.1 -0.2 0.6 0.0
Leg fat-free mass (right) 0.5 2.9 11.3 -3.4 -0.0 0.3 -0.4
Arm fat percentage (left) 0.9 3.8 8.5 -2.9 1.0 1.0 -2.1
Average weekly red wine intake 0.3 0.4 1.5 -0.2 -0.0 -1.2 -0.1
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.9 0.9 -0.0 0.2 -0.6
Mood swings 0.7 1.2 1.8 -1.3 0.4 -1.2 -1.2
Loneliness, isolation 1.8 2.5 7.0 0.7 -1.5 -0.5 -2.6
Long-standing illness, disability or infirmity 1.3 1.9 4.2 -0.7 2.1 -0.5 -1.7
Ever had bowel cancer screening 2.5 2.9 7.1 0.8 2.7 1.9 0.3
Diabetes diagnosed by doctor 1.2 2.0 4.4 -1.4 -0.9 -1.0 -2.1
Ever had stillbirth, spontaneous miscarriage or termination 1.9 2.1 5.9 -0.1 2.4 -1.2 1.0
Friendships satisfaction 1.5 1.9 3.2 0.9 -1.4 -1.3 -1.8
Qualifications: nursing, teaching 0.4 0.7 2.3 -0.1 -1.5 -0.6 -0.1
Commuting to job workplace: Walk 0.3 0.3 0.8 -0.9 -0.7 0.1 -0.2
Eye problems/disorders: Cataract 1.2 1.3 5.0 0.3 2.2 -0.6 -0.0
Mouth/teeth dental problems: Mouth ulcers 1.7 2.7 8.6 1.0 0.9 -0.6 2.9
Medication for cholesterol 0.5 0.7 1.0 -0.8 -0.7 0.8 1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.1 -0.3 -0.1 -1.3 -1.4
Back pain experienced in last month 0.3 0.4 1.0 0.4 1.0 -0.7 -0.3
Mineral and other dietary supplements 0.4 0.5 1.1 -0.4 -1.0 -0.7 -0.4
Breast cancer (self-reported) 1.7 2.0 5.3 -0.6 -0.8 -2.3 -1.4
Asthma (self-reported) 0.4 0.8 2.0 -0.7 0.5 0.6 1.4
Osteoporosis (self-reported) 0.8 1.0 2.1 -1.4 1.4 -0.0 0.3
Osteoarthritis (self-reported) 0.8 1.0 2.3 0.3 1.5 1.0 -0.7
Medication: Aspirin 1.7 2.2 5.6 -0.9 -1.6 -2.4 -0.4
Medication: Gliclazide 0.2 0.3 0.8 -0.1 -0.5 -0.9 -0.0
Illnesses of father: None of the above (group 1) 1.2 1.5 3.7 0.9 1.9 -0.1 -1.2
Smoking status: Current 1.0 1.6 3.8 -0.1 -0.3 -2.0 -1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.6 1.3 0.9 0.5 -1.1 0.1
Whole body water mass 0.5 2.6 10.0 -3.2 -0.0 0.7 0.1
Leg predicted mass (right) 0.5 2.8 11.1 -3.3 -0.1 0.2 -0.4
Arm fat mass (left) 1.2 4.8 13.7 -3.7 0.8 1.0 -1.9
Number of self-reported non-cancer illnesses 1.9 3.3 6.4 -1.5 2.5 0.1 -2.1
Average weekly champagne plus white wine intake 0.7 0.9 2.6 1.6 0.2 -1.0 -0.1
Miserableness 1.9 3.2 10.8 -1.3 -0.4 -3.3 -0.4
Guilty feelings 0.4 0.6 1.9 0.2 -0.1 -1.4 0.6
Wears glasses or contact lenses 2.7 3.1 6.7 -0.8 -1.8 -1.3 -2.6
Ever taken oral contraceptive pill 0.9 1.0 3.1 0.5 -1.8 -0.5 0.6
Hearing aid user 1.1 1.2 2.8 -0.5 -0.7 1.1 -1.7
Mother’s age at death 0.6 0.7 1.4 -1.1 1.2 -0.3 -0.5
Financial situation satisfaction 2.6 3.3 10.9 -0.4 1.3 -0.8 -3.3
Tinnitus: Yes, now most or all of the time 0.4 0.4 1.1 0.6 1.0 -0.2 0.5
Commuting to job workplace: Public transport 0.3 0.3 0.7 0.1 -0.8 0.3 -0.6
Eye problems/disorders: Glaucoma 1.2 1.5 2.9 0.7 -1.6 -0.4 -1.7
Medication: Blood pressure 0.4 0.7 1.3 0.7 0.5 -1.1 -0.8
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.8 -0.9 0.2 -0.3 -0.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.2 0.7 1.1 -0.1 -0.1
High cholesterol (Self-reported) 1.0 1.8 2.9 1.7 1.1 -0.3 -1.7
Medication: Bendroflumethiazide 0.8 1.3 3.6 0.5 -0.8 -0.8 -1.9
Medication: Paracetamol 0.2 0.3 0.7 0.4 0.6 0.9 -0.1
Medication: Lisinopril 2.9 3.7 11.8 1.0 -0.4 -1.4 -3.4
Medication: Atorvastatin 0.8 1.0 2.1 0.9 -0.4 -1.1 -1.4
Illnesses of father: High blood pressure 0.3 0.4 0.8 0.6 -0.7 0.9 0.0
Alcohol drinker status: Never 2.2 2.7 5.2 1.8 2.3 1.4 0.3
Ever smoked 2.2 3.8 12.0 -0.7 -0.5 -3.5 -1.6
Basal metabolic rate 0.6 3.1 12.0 -3.5 -0.0 0.6 -0.3
Leg fat percentage (left) 1.4 5.0 13.2 -3.6 1.8 1.2 -1.4
Arm fat-free mass (left) 0.6 3.0 10.8 -3.3 0.1 1.0 0.3
Number of operations (self-reported) 1.1 1.7 6.3 -0.5 -0.2 0.3 -2.5
Average weekly beer plus cider intake 1.5 2.1 4.9 -2.2 -0.8 1.3 -1.1
Irritability 0.8 1.3 2.1 0.2 1.2 -1.3 -1.4
Risk taking 0.8 1.2 2.3 1.4 0.2 -1.5 -0.6
Ever had prostate specific antigen (PSA) test 0.7 0.8 2.2 -0.9 -0.2 -1.5 -0.2
Fractured/broken bones in last 5 years 0.7 0.9 2.4 0.9 -1.5 -0.3 -0.6
Age started oral contraceptive pill 0.4 0.5 1.7 0.1 -0.2 1.3 -0.2
Diastolic blood pressure, automated reading 0.4 1.2 3.7 -0.4 -0.6 0.9 1.9
Ever depressed for a whole week 1.6 1.9 6.2 -0.5 0.0 -2.5 -1.1
Unable to work because of sickness or disability 0.5 0.7 1.5 -0.9 1.2 -0.4 -0.6
Commuting to job workplace: Cycle 1.4 1.7 3.2 1.2 -1.8 -0.5 -1.3
Myopia 2.4 3.5 8.1 -0.2 -0.5 -2.4 -2.9
Vascular/heart problems diagnosed by doctor 0.5 1.3 2.1 1.1 -0.5 1.4 1.3
Cholesterol lowering medication 0.4 0.6 1.4 -0.3 0.6 -1.2 -0.8
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.8 -0.7 1.3 0.9 -0.1
Pain experienced in last month 0.3 0.5 1.6 0.2 -1.3 0.1 -0.5
Supplements: Calcium 0.3 0.3 0.7 -0.2 -0.1 0.7 0.9
Basal cell carcinoma (self-reported) 0.5 0.6 1.7 -0.6 0.5 0.3 1.3
Heart attack/myocardial infarction (self-reported) 1.2 1.5 4.8 -2.2 -0.0 -0.9 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.1 0.2 0.3 -0.5 0.2 -0.5 -0.4
Heart disease (siblings) 1.0 1.2 3.5 0.0 1.9 1.1 0.4
Alcohol drinker status: Previous 0.4 0.4 1.2 -1.1 0.5 0.0 -0.6
Pack years of smoking 0.7 1.1 2.4 0.0 -1.3 -0.6 -1.6
Impedance of whole body 0.1 0.4 0.7 0.9 -0.5 -0.8 -0.1
Leg fat mass (left) 1.2 4.9 13.7 -3.7 1.1 0.9 -1.9
Arm predicted mass (left) 0.7 3.3 12.3 -3.5 0.3 0.9 0.1