Hub : Genes

ARHGAP18

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1280	0.0350	3.9e-05	0.069	0.050	0.042	0.059	0.061	8.1e-09	8.3e-07	6.5e-06	9.4e-08	6.3e-08
2	GTEx	Nerve Tibial	0.2163	0.0552	3.6e-04	0.085	NA	0.136	NA	0.114	1.4e-06	NA	6.9e-10	NA	1.9e-08
3	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0880	0.0400	4.7e-03	0.111	0.018	0.056	NA	0.027	6.5e-07	3.2e-02	3.8e-04	NA	1.1e-02
4	TCGA	Lung Squamous Cell Carcinoma	0.0565	0.0277	8.7e-03	0.005	0.001	0.023	NA	0.019	7.5e-02	2.6e-01	1.2e-03	NA	2.6e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.7	1.8	-1.3	0.7	-0.5	-0.6
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	-0.7	1.3	-0.0	-1.3
Depressed Affect (Nagel 2018)	1.3	2.8	5.5	-0.3	-0.9	-2.3	-2.2
Depression (Nagel 2018)	0.8	1.1	3.9	0.8	0.0	-0.3	-2.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	0.3	-0.6	-0.6	-0.4
Neuroticism (Nagel 2018)	0.9	2.2	7.1	-0.7	-0.6	-2.7	-0.9
Schizophrenia (2018)	0.3	0.6	1.4	0.2	1.0	0.4	-1.2
Schizophrenia vs Biploar Disorder	0.4	0.6	2.2	1.5	0.3	-0.1	0.3
Worry (Nagel 2018)	0.4	0.9	3.2	-0.5	-0.4	-1.8	-0.1
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.9	0.0	0.3	-0.6
Alzheimer’s Disease (in father)	1.6	1.7	4.5	-0.2	-1.0	-2.1	-1.1
Alzheimer’s Disease (including proxy)	0.4	0.6	1.2	-0.1	0.2	-1.1	-1.0
Crohns Disease (2017)	0.3	0.7	1.6	0.2	-0.6	-1.2	1.0
Irritable Bowel Disease (IBD)	0.3	0.7	2.4	-0.3	0.0	-0.5	1.5
Ulcerative Colitis (UC)	0.4	0.8	2.7	-0.8	0.4	0.0	1.6
Major Depression (MDD)	2.1	2.6	5.6	-0.2	-0.3	-2.4	-2.1
Reaction Time	1.0	1.9	5.7	0.3	2.4	1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.5	-0.1	-0.8	-1.2	-0.6
Breast Cancer	1.0	2.5	8.1	1.4	-0.1	2.8	-0.3
Ovarian Cancer	0.2	0.3	0.6	-0.1	0.7	0.8	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.6	0.9	1.4	-1.2	-1.2	-0.0	0.9
Bipolar Disorder (2011)	2.0	1.9	2.5	-1.6	-1.4	-0.8	-1.6
Body Mass Index (BMI) (2010)	0.4	0.5	0.8	-0.7	-0.9	-0.1	-0.9
Coronary Artery Disease (CAD)	2.0	2.4	3.8	-0.2	-2.0	-1.8	-1.6
Crohns Disease (2012)	1.0	1.6	2.2	0.8	-1.5	-1.4	1.3
Mean Putamen Volume	2.1	2.4	5.2	1.2	1.6	-0.6	-2.3
Fasting Glucose	0.6	0.8	1.5	0.8	-0.8	-0.3	-1.2
HbA1C	2.3	2.6	5.3	1.6	-1.4	-2.3	-0.8
HDL Cholesterol	0.4	0.7	1.7	-0.2	1.3	0.9	-0.0
LDL Cholesterol	1.1	1.7	4.2	-1.0	2.1	0.8	0.9
Lupus	1.7	2.6	6.1	-0.8	1.9	2.5	0.2
Neuroticism (2016)	0.8	1.1	4.4	-0.0	0.1	-2.1	-0.2
Primary Biliary Cirrhosis	1.6	2.3	7.9	-2.8	0.4	0.9	0.5
Rheumatoid Arthritis	1.4	1.9	6.3	0.4	2.5	-0.2	-1.1
Schizophrenia (2014)	0.7	1.4	2.6	0.8	1.4	0.7	-1.6
Triglycerides	0.2	0.3	0.8	0.9	-0.5	-0.5	-0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.2	0.2	1.2	0.0	-1.5
Ulcerative Colitis	0.5	0.7	1.1	-0.9	-1.1	-0.6	0.8
Blood Eosinophil Count	0.4	3.4	9.2	-3.0	1.2	1.1	-1.3
Blood Platelet Count	0.2	2.0	7.1	2.7	0.6	0.4	0.8
Blood Red Count	0.3	2.7	6.2	-2.5	1.8	1.0	0.6
Blood White Count	0.1	1.1	4.0	0.1	-0.4	-0.3	-2.0
Heel T-Score	0.6	5.1	10.9	-1.8	3.3	2.4	-0.5
BMI	0.6	3.2	8.8	-3.0	1.0	1.6	-0.7
Height	0.5	9.1	32.9	-5.7	-1.4	-0.9	0.8
Waist Hip Ratio (WHR)	0.2	0.8	2.9	-0.3	0.2	0.5	-1.7
Systolic Blood Pressure	0.6	3.0	7.6	1.9	-2.8	-1.0	0.0
Smoking Status	1.5	3.5	7.6	-0.2	-1.1	-2.8	-2.3
Allergy or Eczema	0.2	0.6	1.6	0.6	0.2	1.3	0.5
Cardiovascular Disease	0.3	0.9	3.2	0.3	0.2	-0.4	-1.8
Hypothyroidism (self reported)	0.4	1.0	2.2	-1.5	1.2	0.4	-0.6
Respiratory disease	0.6	1.3	2.6	-1.4	-0.3	1.6	0.8
Type 2 Diabetes (T2D) (2018)	1.7	3.2	5.3	-1.4	-1.8	-1.4	-2.3
Lung FEV1/FVC ratio	0.3	1.7	3.4	1.1	1.9	-0.5	-1.4
Lung FVC	0.3	1.3	3.5	1.3	0.5	-0.2	1.9
Neuroticism	0.5	1.2	3.9	-0.2	0.1	-2.0	-0.9
Chronotype (morning person)	0.8	1.9	4.8	1.6	-2.2	0.5	-0.0
Hair Pigment	0.0	0.8	2.2	1.5	-0.1	0.9	-0.5
Tanning	0.1	1.6	2.9	-1.6	0.2	-1.7	-1.0
Hand grip strength (left)	0.4	1.2	2.3	-0.6	-1.0	-1.5	1.0
Number of treatments/medications taken	1.1	2.1	3.4	-1.2	1.5	-1.1	-1.8
Average weekly spirits intake	1.1	1.4	2.1	1.3	1.4	1.3	-0.1
Sensitivity / hurt feelings	1.2	2.0	6.9	-0.0	0.4	-2.6	1.0
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.6	-0.2	0.4	-1.1	-1.3
Hearing difficulty/problems: Yes	1.7	2.6	8.9	-0.8	3.0	-0.6	-0.8
Relative age of first facial hair	0.5	1.0	3.9	-0.0	2.0	-0.1	0.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	5.6	0.4	2.4	0.0	-1.1
Ever used hormone-replacement therapy (HRT)	1.2	1.5	3.7	0.4	1.5	0.2	-1.9
Ever had hysterectomy (womb removed)	2.5	2.8	9.5	-1.2	-0.3	0.5	-3.1
Systolic blood pressure, automated reading	0.4	1.0	2.2	0.7	-1.5	0.9	0.8
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.0	-0.4	-0.5	-1.4	-0.2
Angina	1.0	1.4	4.2	-0.7	0.1	-0.9	-2.0
Medication for hormone replacement therapy	0.8	0.9	2.9	0.8	-0.2	0.3	-1.7
Vitamin and mineral supplements	0.2	0.2	0.5	-0.7	-0.3	-0.6	0.1
Supplements: Zinc	0.8	0.9	1.8	-1.3	0.3	1.3	-0.0
Medication: Co-codamol	2.0	2.3	6.5	-1.5	-0.3	-0.4	-2.5
Medication: Metformin	0.7	1.0	3.2	-1.8	0.1	-0.8	-0.3
Diabetes (father)	0.8	1.0	1.8	-1.3	-0.5	0.4	1.3
Diabetes (mother)	0.2	0.2	0.6	-0.4	-0.8	-0.4	-0.1
Severe depression (siblings)	0.8	0.9	1.3	-0.7	-0.8	-1.1	-1.0
Pack years adult smoking proportion	0.8	1.2	2.8	0.3	-1.3	-0.5	-1.7
Impedance of leg (right)	0.1	0.3	0.7	0.8	-0.2	-0.5	-0.3
Leg fat-free mass (left)	0.4	2.1	8.0	-2.8	-0.1	0.2	-0.7
Trunk fat percentage	1.0	4.1	11.9	-3.5	0.7	0.2	-2.0
Hand grip strength (right)	0.7	2.0	4.6	-0.3	-1.8	-2.1	0.5
Townsend deprivation index at recruitment	0.5	0.7	1.2	-1.1	1.0	0.8	-0.3
Current tobacco smoking	1.1	1.8	3.6	-0.4	-0.5	-1.9	-1.8
Average weekly fortified wine intake	0.6	0.7	1.5	1.2	-0.3	1.1	0.4
Maternal smoking around birth	0.7	1.0	3.7	0.3	-1.9	-0.4	-0.3
Fed-up feelings	1.2	2.2	4.4	-0.1	-1.4	-2.1	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.3	1.7	6.6	0.2	-0.5	-0.1	-2.6
Relative age voice broke	0.6	0.9	3.1	0.4	-0.2	0.5	1.8
Taking other prescription medications	1.7	2.7	5.6	-1.7	2.4	-0.4	-1.5
Age when periods started (menarche)	1.1	2.5	8.7	1.0	0.1	-3.0	-0.7
Bilateral oophorectomy (both ovaries removed)	1.6	1.8	2.8	-1.6	-1.1	-0.9	-1.7
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.2	0.5	-0.7	0.2	-0.4	-0.1
Tinnitus: Yes, but not now, but have in the past	2.4	2.6	3.6	1.3	1.6	-1.9	-1.6
Qualifications: CSEs or equivalent	0.7	1.0	2.0	-1.1	-0.6	-0.6	-1.4
Serious illness, injury or assault to yourself	1.8	2.2	4.6	1.5	-1.0	-2.1	-1.0
High blood pressure	0.3	0.9	1.8	-0.8	0.3	-1.0	-1.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.3	1.8	-0.4	0.9	0.1
Multivitamins +/- minerals	1.1	1.4	4.2	0.6	-0.9	0.5	-2.0
Stomach or abdominal pain in last month	0.4	0.6	1.4	-0.4	1.2	-0.7	-0.3
Supplements: Glucosamine	0.5	0.7	1.9	0.3	-1.4	-0.1	-0.9
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.6	0.2	0.8	-0.3	0.0
Medication: Atenolol	0.7	0.9	1.5	-1.1	0.7	-1.2	-0.6
Medication: Levothyroxine sodium	0.8	1.3	3.4	-1.8	1.3	-0.4	0.3
Sitting height	0.2	1.1	2.2	-1.4	-1.5	-0.4	0.5
Chronic bronchitis/emphysema (father)	0.8	1.0	2.4	-0.6	-1.6	0.6	-0.9
High blood pressure (mother)	0.5	0.7	1.7	-0.1	-1.3	-0.4	0.8
Body mass index (BMI)	0.6	2.8	6.4	-2.5	0.8	1.4	-1.4
Impedance of leg (left)	0.0	0.1	0.2	-0.1	-0.1	-0.5	-0.1
Leg predicted mass (left)	0.4	2.1	7.9	-2.8	-0.1	0.3	-0.7
Trunk fat mass	1.1	4.9	15.2	-3.9	0.7	0.4	-1.9
Waist circumference	0.9	3.4	7.9	-2.8	0.3	1.3	-2.0
Number of incorrect matches in round	0.9	1.5	3.5	1.9	-0.7	0.7	-1.3
Past tobacco smoking	1.2	2.1	6.4	0.5	0.3	2.5	1.4
Alcohol usually taken with meals	0.1	0.2	0.7	0.3	0.9	0.2	0.1
Nervous feelings	0.3	0.6	2.1	-0.5	-0.1	-1.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	8.2	-1.1	1.0	-2.9	-0.4
Hearing difficulty/problems with background noise	2.4	3.8	7.0	-1.8	1.9	-1.1	-2.6
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	-0.7	-1.7	-0.4	0.7
Had menopause	1.8	2.2	5.2	-1.2	2.3	1.2	-0.7
Had other major operations	0.8	0.9	2.4	0.8	0.6	-0.7	-1.5
Forced vital capacity (FVC)	0.4	1.6	3.2	-0.3	0.1	-1.7	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.0	-0.5	-0.3	-0.4	-1.4
Ever unenthusiastic/disinterested for a whole week	4.1	5.0	15.2	-0.9	-0.8	-3.9	-1.8
Qualifications: None of the above	0.2	0.5	0.8	-0.9	0.9	-0.5	-0.2
Financial difficulties in last 2 years	1.4	1.9	6.6	0.6	0.3	0.8	-2.6
Mouth/teeth dental problems	0.8	1.2	2.0	1.4	0.2	0.9	-1.4
Heart attack	1.5	1.9	4.6	-2.1	-0.4	-1.5	-0.8
Allergy	0.2	0.5	1.0	-1.0	-0.1	-0.5	-0.9
Pain all over the body in last month	1.8	2.0	7.1	-2.7	0.5	-0.5	-0.5
Diabetes (self-reported)	0.4	0.7	1.4	-0.3	-0.4	-1.1	-1.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.6	0.4	-0.1	0.3
Medication: Ramipril	0.4	0.5	1.3	-0.8	-0.0	-0.1	-1.1
Medication: Simvastatin	0.6	0.8	1.7	0.6	-0.6	-0.9	-1.3
Fluid intelligence score	0.1	0.2	0.5	0.5	-0.7	-0.1	0.2
Illnesses of siblings	0.8	1.2	2.0	0.5	-1.4	0.7	1.4
Neuroticism score	0.8	1.7	6.6	-0.5	-0.2	-2.6	-0.1
Weight	0.9	4.4	15.4	-3.9	0.5	1.0	-0.9
Impedance of arm (right)	0.3	1.3	2.3	1.5	-1.2	-1.1	-0.5
Arm fat percentage (right)	0.7	2.9	6.4	-2.5	0.7	0.8	-2.0
Trunk fat-free mass	0.4	2.3	8.4	-2.9	-0.2	0.7	0.5
Hip circumference	0.5	2.1	7.1	-2.7	0.4	1.1	-0.2
Time employed in main current job	0.6	0.7	1.4	0.9	-0.2	-1.2	-0.7
Alcohol intake versus 10 years previously	2.7	4.0	9.8	-3.1	1.1	-1.5	-1.7
Father’s age at death	1.7	2.3	5.2	1.1	1.6	-0.5	2.3
Worrier / anxious feelings	0.3	0.5	0.9	-0.6	-0.9	-0.5	0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	2.0	-1.3	-0.4	-0.6	-1.4
Falls in the last year	1.3	1.8	5.1	-0.0	0.7	-1.2	-2.2
Hair/balding pattern: Pattern 3	1.1	1.6	3.7	0.0	1.5	1.9	0.5
Number of live births	0.5	0.8	2.6	1.6	0.3	-0.4	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.3	0.7	0.1	-1.8	1.5
Pulse rate	0.2	0.4	0.6	-0.6	0.8	0.3	0.7
Happiness	0.9	1.1	3.5	0.1	-0.6	-0.8	-1.9
Noisy workplace	0.4	0.4	1.3	0.3	-0.4	-1.2	-0.4
Qualifications: A levels/AS levels or equivalent	0.6	1.4	4.0	0.2	-0.7	1.0	2.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.0	-0.0	-0.9	-0.0
Mouth/teeth dental problems: Dentures	1.3	2.2	6.6	-2.6	-1.2	-0.9	-0.0
Asthma	0.5	1.0	2.0	-1.0	0.5	0.7	1.4
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	3.3	1.2	1.0	1.3	-1.8
Medication: Cholesterol lowering	0.7	1.0	3.2	0.4	-0.5	-0.7	-1.8
Depression (self-reported)	2.1	2.5	3.9	-1.2	2.0	-1.7	-1.4
Medication: Lansoprazole	0.8	0.9	2.1	-1.2	1.4	-0.3	-0.3
Prospective memory result	2.4	2.9	7.0	-2.6	1.7	1.4	-0.2
Lung cancer (father)	1.4	1.6	3.6	-0.4	-0.5	-1.5	-1.9
Illnesses of mother	0.1	0.1	0.4	0.6	0.1	-0.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.8	2.0	0.3	0.3	-1.1	1.4
Pulse wave Arterial Stiffness index	0.9	1.1	4.0	-2.0	0.5	0.1	0.4
Impedance of arm (left)	0.2	0.7	1.3	1.1	-0.8	-0.9	-0.3
Arm fat mass (right)	1.0	3.9	10.8	-3.3	0.6	0.9	-1.9
Trunk predicted mass	0.4	2.2	7.8	-2.8	-0.2	0.8	0.5
Standing height	0.3	3.3	10.7	-3.3	-1.1	-0.7	0.8
Length of working week for main job	1.8	2.0	3.7	-1.2	1.6	1.9	0.6
Exposure to tobacco smoke at home	0.4	0.4	0.7	-0.9	0.8	0.2	0.6
Breastfed as a baby	1.0	1.2	4.1	-0.0	0.0	-2.0	-0.8
Tense / ‘highly strung’	0.9	1.6	5.5	-0.8	-0.4	-2.3	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	4.5	-1.9	-1.2	-1.7	-2.1
Hair/balding pattern: Pattern 4	0.6	1.5	4.2	0.1	-2.1	0.6	-1.2
Birth weight of first child	0.1	0.2	0.4	-0.4	-0.6	-0.2	-0.5
Peak expiratory flow (PEF)	0.9	2.0	6.2	0.4	-1.0	-2.5	0.9
Pulse wave reflection index	0.4	0.5	1.1	-1.0	-0.1	0.8	-0.4
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.2	-1.5	-0.3	-1.4	-1.5
Loud music exposure frequency	0.4	0.4	0.8	0.6	0.6	-0.9	-0.3
Qualifications: O levels/GCSEs or equivalent	1.2	2.0	3.7	1.7	-1.9	0.6	-1.0
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.9	0.6	1.7	-0.7	-0.2
Blood clot in the leg (DVT)	0.1	0.2	0.4	-0.6	0.3	-0.5	-0.3
Medication: Paracetamol	0.2	0.3	0.6	0.7	0.5	0.8	0.1
Headache pain in last month	0.2	0.4	0.6	-0.7	-0.0	-0.7	0.8
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	6.5	0.3	0.4	-0.0	2.5
Glaucoma (self-reported)	1.3	1.6	5.2	0.9	-0.4	-0.1	-2.3
Gout (self-reported)	2.4	3.3	7.0	0.2	-2.7	-1.4	-2.0
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	3.8	-1.4	1.9	0.0	-0.5
Medication: Amlodipine	3.4	4.8	11.1	-0.8	-3.3	-1.1	-2.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.4	0.6	-0.1	0.2	0.1
Birth weight	0.2	0.3	1.1	-1.1	-0.0	0.2	0.4
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.3	-0.2	-0.1	0.4	-0.6
High blood pressure (siblings)	1.3	1.8	4.4	-0.7	0.1	-1.6	-2.1
Forced vital capacity (FVC), Best measure	0.3	1.1	3.4	-0.4	-0.2	-1.0	1.9
Body fat percentage	1.1	4.3	12.2	-3.5	0.9	0.4	-2.0
Leg fat percentage (right)	1.1	4.1	9.6	-3.1	1.7	1.3	-1.6
Arm fat-free mass (right)	0.7	3.5	13.0	-3.6	0.3	0.8	-0.1
Exposure to tobacco smoke outside home	0.3	0.4	1.0	0.5	-0.2	-0.5	-1.0
Comparative body size at age 10	0.1	0.2	0.6	0.8	0.3	0.2	0.4
Number of full brothers	0.4	0.5	1.3	0.5	1.1	0.6	-0.2
Worry too long after embarrassment	0.6	1.0	1.5	-1.0	-0.9	-1.2	0.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	4.9	-1.2	1.6	-2.2	-1.2
Wheeze or whistling in the chest in last year	0.6	1.0	1.8	-1.3	1.1	0.8	-0.7
Number of children fathered	0.2	0.3	0.6	0.8	-0.6	0.1	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	0.0	-0.6	0.1	0.9
Age at first live birth	0.6	1.0	3.1	1.8	0.8	0.6	-0.2
Pulse wave peak to peak time	0.8	0.9	3.3	1.8	-0.5	-0.2	-0.4
Health satisfaction	1.2	1.6	5.4	-0.0	-1.0	-0.3	-2.3
Shortness of breath walking on level ground	1.4	1.6	3.8	-0.3	1.3	1.0	1.9
Qualifications: College or University degree	0.3	1.0	3.3	-0.8	-1.8	-0.4	0.4
Eye problems/disorders: None of the above	0.2	0.2	0.5	-0.7	-0.1	0.5	0.2
Mouth/teeth dental problems: Loose teeth	1.0	1.2	1.8	-1.1	-1.3	-1.2	0.5
Emphysema/chronic bronchitis	0.1	0.2	0.5	-0.1	0.7	0.1	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	0.9	0.0	-1.0	0.7	0.5
Neck or shoulder pain in last month	0.4	0.5	0.8	-0.4	0.8	-0.9	-0.6
Medication: Blood pressure	0.9	1.5	3.2	-0.4	-1.6	-0.3	-1.8
Angina (self-reported)	1.1	1.5	4.6	-0.7	-0.0	-0.9	-2.1
Migraine (self-reported)	1.4	1.8	6.0	0.3	-0.4	1.0	2.4
Medication: Ibuprofen	0.9	1.0	1.8	0.5	1.3	0.6	-1.3
Medication: Allopurinol	1.4	1.9	3.0	0.8	-1.7	-1.2	-1.6
Medication: Omeprazole	0.5	0.6	1.2	-1.1	1.0	0.2	-0.5
Medication: Seretide 50 evohaler	2.3	2.7	7.1	0.2	2.7	1.8	0.7
Mean time to correctly identify matches	0.9	1.6	5.4	0.5	2.3	0.7	-0.7
Heart disease (mother)	2.9	3.5	5.6	-2.0	2.4	1.3	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.1	-0.4	1.0	-0.5	-1.0
Whole body fat mass	1.2	4.9	15.6	-4.0	0.5	0.4	-1.9
Leg fat mass (right)	1.2	4.7	12.2	-3.5	1.0	1.0	-2.1
Arm predicted mass (right)	0.6	3.0	11.3	-3.4	0.2	0.9	-0.2
Pulse rate, automated reading	0.1	0.4	1.2	-1.1	0.1	-0.3	0.4
Alcohol intake frequency.	0.4	0.9	3.1	-0.6	1.8	0.3	0.5
Comparative height size at age 10	1.2	6.5	20.0	-4.5	-0.9	0.5	2.2
Number of full sisters	1.4	1.7	4.1	0.7	0.1	-2.0	-1.4
Suffer from ‘nerves’	1.4	2.3	4.8	-2.1	0.1	-2.2	-0.2
Overall health rating	1.0	2.2	7.8	-0.6	-0.7	0.2	-2.8
Chest pain or discomfort	3.1	4.5	6.6	-2.6	-0.9	-2.2	-2.4
Had major operations	1.8	2.2	4.0	0.5	-1.7	-2.0	-1.2
Age at last live birth	0.1	0.2	0.4	0.2	0.2	-0.6	0.5
Family relationship satisfaction	1.7	2.1	2.9	1.5	0.9	-1.7	-1.5
Leg pain on walking	0.5	0.7	1.8	-0.0	1.4	-0.6	-0.7
Qualifications: NVQ or HND or HNC or equivalent	1.7	2.1	5.3	0.8	0.4	-2.3	-1.5
Commuting to job workplace: Car/motor vehicle	0.1	0.1	0.3	0.5	-0.2	-0.1	-0.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.7	2.4	-0.4	-0.3	-0.3	1.6
Medication: Aspirin	1.3	1.7	4.8	-0.8	-1.1	-2.2	-0.4
Supplements: Vitamin C	0.7	0.8	2.5	0.0	0.9	-0.2	1.6
Knee pain experienced in last month	0.2	0.3	1.3	-0.2	-0.0	-0.3	-1.1
Hypertension (Self-reported)	0.4	1.1	2.1	-1.1	-0.2	-1.1	-1.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	4.2	0.2	2.1	0.8	0.4
Illnesses of father: Heart disease	0.6	0.8	2.0	-1.0	0.4	0.3	1.4
Illnesses of siblings: Diabetes	1.2	1.5	4.2	-0.3	2.0	-0.3	-1.3
Smoking status: Previous	0.6	0.9	2.4	-0.6	-0.1	-1.5	-0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.6	-0.8	-0.7	-0.7	-0.3
Whole body fat-free mass	0.4	2.4	9.4	-3.1	-0.2	0.6	0.0
Leg fat-free mass (right)	0.5	2.9	11.3	-3.4	-0.0	0.3	-0.4
Arm fat percentage (left)	0.9	3.8	8.5	-2.9	1.0	1.0	-2.1
Average weekly red wine intake	0.3	0.4	1.5	-0.2	-0.0	-1.2	-0.1
Handedness (chirality/laterality): Left-handed	0.3	0.3	0.9	0.9	-0.0	0.2	-0.6
Mood swings	0.7	1.2	1.8	-1.3	0.4	-1.2	-1.2
Loneliness, isolation	1.8	2.5	7.0	0.7	-1.5	-0.5	-2.6
Long-standing illness, disability or infirmity	1.3	1.9	4.2	-0.7	2.1	-0.5	-1.7
Ever had bowel cancer screening	2.5	2.9	7.1	0.8	2.7	1.9	0.3
Diabetes diagnosed by doctor	1.2	2.0	4.4	-1.4	-0.9	-1.0	-2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.9	2.1	5.9	-0.1	2.4	-1.2	1.0
Friendships satisfaction	1.5	1.9	3.2	0.9	-1.4	-1.3	-1.8
Qualifications: nursing, teaching	0.4	0.7	2.3	-0.1	-1.5	-0.6	-0.1
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.9	-0.7	0.1	-0.2
Eye problems/disorders: Cataract	1.2	1.3	5.0	0.3	2.2	-0.6	-0.0
Mouth/teeth dental problems: Mouth ulcers	1.7	2.7	8.6	1.0	0.9	-0.6	2.9
Medication for cholesterol	0.5	0.7	1.0	-0.8	-0.7	0.8	1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.1	-0.3	-0.1	-1.3	-1.4
Back pain experienced in last month	0.3	0.4	1.0	0.4	1.0	-0.7	-0.3
Mineral and other dietary supplements	0.4	0.5	1.1	-0.4	-1.0	-0.7	-0.4
Breast cancer (self-reported)	1.7	2.0	5.3	-0.6	-0.8	-2.3	-1.4
Asthma (self-reported)	0.4	0.8	2.0	-0.7	0.5	0.6	1.4
Osteoporosis (self-reported)	0.8	1.0	2.1	-1.4	1.4	-0.0	0.3
Osteoarthritis (self-reported)	0.8	1.0	2.3	0.3	1.5	1.0	-0.7
Medication: Aspirin	1.7	2.2	5.6	-0.9	-1.6	-2.4	-0.4
Medication: Gliclazide	0.2	0.3	0.8	-0.1	-0.5	-0.9	-0.0
Illnesses of father: None of the above (group 1)	1.2	1.5	3.7	0.9	1.9	-0.1	-1.2
Smoking status: Current	1.0	1.6	3.8	-0.1	-0.3	-2.0	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.3	0.9	0.5	-1.1	0.1
Whole body water mass	0.5	2.6	10.0	-3.2	-0.0	0.7	0.1
Leg predicted mass (right)	0.5	2.8	11.1	-3.3	-0.1	0.2	-0.4
Arm fat mass (left)	1.2	4.8	13.7	-3.7	0.8	1.0	-1.9
Number of self-reported non-cancer illnesses	1.9	3.3	6.4	-1.5	2.5	0.1	-2.1
Average weekly champagne plus white wine intake	0.7	0.9	2.6	1.6	0.2	-1.0	-0.1
Miserableness	1.9	3.2	10.8	-1.3	-0.4	-3.3	-0.4
Guilty feelings	0.4	0.6	1.9	0.2	-0.1	-1.4	0.6
Wears glasses or contact lenses	2.7	3.1	6.7	-0.8	-1.8	-1.3	-2.6
Ever taken oral contraceptive pill	0.9	1.0	3.1	0.5	-1.8	-0.5	0.6
Hearing aid user	1.1	1.2	2.8	-0.5	-0.7	1.1	-1.7
Mother’s age at death	0.6	0.7	1.4	-1.1	1.2	-0.3	-0.5
Financial situation satisfaction	2.6	3.3	10.9	-0.4	1.3	-0.8	-3.3
Tinnitus: Yes, now most or all of the time	0.4	0.4	1.1	0.6	1.0	-0.2	0.5
Commuting to job workplace: Public transport	0.3	0.3	0.7	0.1	-0.8	0.3	-0.6
Eye problems/disorders: Glaucoma	1.2	1.5	2.9	0.7	-1.6	-0.4	-1.7
Medication: Blood pressure	0.4	0.7	1.3	0.7	0.5	-1.1	-0.8
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.8	-0.9	0.2	-0.3	-0.0
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.2	0.7	1.1	-0.1	-0.1
High cholesterol (Self-reported)	1.0	1.8	2.9	1.7	1.1	-0.3	-1.7
Medication: Bendroflumethiazide	0.8	1.3	3.6	0.5	-0.8	-0.8	-1.9
Medication: Paracetamol	0.2	0.3	0.7	0.4	0.6	0.9	-0.1
Medication: Lisinopril	2.9	3.7	11.8	1.0	-0.4	-1.4	-3.4
Medication: Atorvastatin	0.8	1.0	2.1	0.9	-0.4	-1.1	-1.4
Illnesses of father: High blood pressure	0.3	0.4	0.8	0.6	-0.7	0.9	0.0
Alcohol drinker status: Never	2.2	2.7	5.2	1.8	2.3	1.4	0.3
Ever smoked	2.2	3.8	12.0	-0.7	-0.5	-3.5	-1.6
Basal metabolic rate	0.6	3.1	12.0	-3.5	-0.0	0.6	-0.3
Leg fat percentage (left)	1.4	5.0	13.2	-3.6	1.8	1.2	-1.4
Arm fat-free mass (left)	0.6	3.0	10.8	-3.3	0.1	1.0	0.3
Number of operations (self-reported)	1.1	1.7	6.3	-0.5	-0.2	0.3	-2.5
Average weekly beer plus cider intake	1.5	2.1	4.9	-2.2	-0.8	1.3	-1.1
Irritability	0.8	1.3	2.1	0.2	1.2	-1.3	-1.4
Risk taking	0.8	1.2	2.3	1.4	0.2	-1.5	-0.6
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.2	-0.9	-0.2	-1.5	-0.2
Fractured/broken bones in last 5 years	0.7	0.9	2.4	0.9	-1.5	-0.3	-0.6
Age started oral contraceptive pill	0.4	0.5	1.7	0.1	-0.2	1.3	-0.2
Diastolic blood pressure, automated reading	0.4	1.2	3.7	-0.4	-0.6	0.9	1.9
Ever depressed for a whole week	1.6	1.9	6.2	-0.5	0.0	-2.5	-1.1
Unable to work because of sickness or disability	0.5	0.7	1.5	-0.9	1.2	-0.4	-0.6
Commuting to job workplace: Cycle	1.4	1.7	3.2	1.2	-1.8	-0.5	-1.3
Myopia	2.4	3.5	8.1	-0.2	-0.5	-2.4	-2.9
Vascular/heart problems diagnosed by doctor	0.5	1.3	2.1	1.1	-0.5	1.4	1.3
Cholesterol lowering medication	0.4	0.6	1.4	-0.3	0.6	-1.2	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	-0.7	1.3	0.9	-0.1
Pain experienced in last month	0.3	0.5	1.6	0.2	-1.3	0.1	-0.5
Supplements: Calcium	0.3	0.3	0.7	-0.2	-0.1	0.7	0.9
Basal cell carcinoma (self-reported)	0.5	0.6	1.7	-0.6	0.5	0.3	1.3
Heart attack/myocardial infarction (self-reported)	1.2	1.5	4.8	-2.2	-0.0	-0.9	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.1	0.2	0.3	-0.5	0.2	-0.5	-0.4
Heart disease (siblings)	1.0	1.2	3.5	0.0	1.9	1.1	0.4
Alcohol drinker status: Previous	0.4	0.4	1.2	-1.1	0.5	0.0	-0.6
Pack years of smoking	0.7	1.1	2.4	0.0	-1.3	-0.6	-1.6
Impedance of whole body	0.1	0.4	0.7	0.9	-0.5	-0.8	-0.1
Leg fat mass (left)	1.2	4.9	13.7	-3.7	1.1	0.9	-1.9
Arm predicted mass (left)	0.7	3.3	12.3	-3.5	0.3	0.9	0.1